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systemic lupus erythomatosus

Rachel Ettinger, Jodi L Karnell, Jill Henault, Santosh K Panda, Jeffrey M Riggs, Roland Kolbeck, Miguel A Sanjuan
Autoantibodies of the IgG subclass are pathogenic in a number of autoimmune disorders such as systemic lupus erythomatosus. The presence of circulating IgE autoantibodies in autoimmune patients has also been known for almost 40 years. Despite their role in allergies, IgE autoantibodies are not associated with a higher rate of atopy in these patients. However, recently they have been recognized as active drivers of autoimmunity through mechanisms involving the secretion of Type I interferons by plasmacytoid dendritic cells (pDC), the recruitment of basophils to lymph nodes, and the activation of adaptive immune responses through B and T cells...
February 2017: Autoimmunity
Karlijn J Van Stralen, Enrico Verrina, Mirco Belingheri, Jan Dudley, Jirí Dusek, Ryszard Grenda, Marie-Alice Macher, Zvonimir Puretic, Jacek Rubic, Sarunas Rudaitis, Christoph Rudin, Franz Schaefer, Kitty J Jager
BACKGROUND: Some kidney diseases tend to recur in the renal allograft after transplantation. We studied the risk of graft loss among primary renal diseases known for their high risk of recurrence and compared it with that of patients with hypoplasia and/or dysplasia. METHODS: Within the European Society of Paediatric Nephrology and European Renal Association and European Dialysis and Transplant Association (ESPN/ERA-EDTA) registry, we studied children from 33 countries who received a kidney transplant before the age of 20 between 1990 and 2009...
April 2013: Nephrology, Dialysis, Transplantation
Yu-hong Shi, Ru Li, Shi Chen, Yin Su, Yuan Jia
OBJECTIVE: To investigate the clinical features and prognosis of mixed connective tissue disease (MCTD). METHODS: Clinical, laboratory and instrumental examination information of 91 patients with MCTD,who were diagnosed between 1990 to 2008 in Peking University People's Hospital, were collected and analyzed retrospectively. These patients were following-up, and different outcoms compared. RESULTS: The most common manifestations of MCTD patients were Raynaud phenomenon, arthralgia, arthritis, fever, acratia, positivities of antinuclear antibodies (anti-ANA) and ribosenuclear protein antibodies (anti-RNP), which were 94...
April 18, 2012: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
Konstantia-Maria Chavele, Michael R Ehrenstein
Regulatory T-cells (Tregs) are the guardians of peripheral tolerance acting to prevent autoimmune diseases such as systemic lupus erythomatosus (SLE) and rheumatoid arthritis (RA). Defects in Tregs have been reported in these two diseases despite significant differences in their clinical phenotype and pathogenesis. In both diseases the potency of Treg fails to keep pace with the activation of effector cells and are unable to resist the ensuing inflammation. This review will discuss the phenotypic, numeric, and functional abnormalities in Tregs and their role in patients and murine models of SLE and RA...
December 1, 2011: FEBS Letters
Ewa Robak, Agnieszka Wierzbowska, Magdalena Chmiela, Liliana Kulczycka, Anna Sysa-Jedrejowska, Tadeusz Robak
We investigated the serum concentration of total metalloproteinase-9 (tMPP-9), active MMP-9 (aMMP-9), and tissue inhibitor of metalloproteinase-1 (TIMP-1) in a group of 41 patients with SLE and 20 healthy controls. Serum levels of tMMP-9 and TIMP-1 were assessed by an enzyme-linked immunosorbent assay (ELISA) and aMMP-9 by fluorometric assay. The tMMP-9 level was lower in SLE patients (mean 262 ng/mL) than in healthy volunteers (mean 325 ng/mL) (P = .048). Similarly, aMMP-9 level was lower in SLE patients (mean 121 ng/mL) than in control group (mean 169 ng/mL) (P = ...
2006: Mediators of Inflammation
Borna Mehrad, Stacy J Park, Gangaram Akangire, Theodore J Standiford, Tianfu Wu, Jiankun Zhu, Chandra Mohan
The genetic predisposition to many autoimmune diseases is inherited as a polygenic trait. It is conceivable that some of the causative alleles in these diseases became prevalent in the population by conferring a survival benefit against environmental assaults, such as infections. We used mice cogenic for genetic loci predisposing to systemic lupus erythomatosus to test the hypothesis that some of these genetic loci protect the host from bacterial infections. Mice with the Sle3 lupus-susceptibility locus on a wild-type background were found to have enhanced antibacterial responses in the context of pneumonia and intra-abdominal sepsis than wild-type animals...
March 1, 2006: Journal of Immunology: Official Journal of the American Association of Immunologists
Zenobia Czuszyńska, Grzegorz Romanowicz
BACKGROUND: The aim of the study was to assess myocardial perfusion in women with systemic lupus erythomatosus (SLE) and no symptoms of coronary artery disease (CAD). MATERIAL AND METHODS: Twenty two women with SLE of mean age 40.5 +/- 7.2 were enrolled in the study. The average duration time of the disease was from 2 to 19 years, mean 8 +/- 4.6 years. The inclusion criterion was the absence of stenocardial symptoms. The myocardial perfusion was studied by using Single Photon Emission Computerized Tomography (SPECT) utilising (99m)Tc-MIBI and a triple-head gamma-camera...
2004: Nuclear Medicine Review. Central & Eastern Europe
M Masilamani, R Nowack, T Witte, M Schlesier, K Warnatz, M O Glocker, H H Peter, H Illges
A soluble form of the complement receptor CD21 (sCD21) is shed from the lymphocyte surface. The amount of sCD21 in serum may modulate immunity as sCD21 levels are correlated with several clinical conditions. We report here the serum levels of sCD21 in juvenile arthritis (JA), systemic lupus erythematosus (SLE) and Sjogren's syndrome (SS). Using enzyme-linked immunosorbent assay, we determined sCD21 levels in SLE, SS and JA patients. Mann-Whitney test for nonparametric two-tail P value was performed to obtain statistical significance...
December 2004: Scandinavian Journal of Immunology
P W Chin, C K Koh, K T Wong
A 28-year-old lady suffering from systemic lupus erythomatosus (SLE) with diffuse proliferative glomerulonephritis (DPGN) and who was on oral cyclophosphamide and prednisolone presented with left lower limb 'cellulitis'. The 'cellulitis' of the left lower limb failed to respond to usual antibiotics which prompted evaluation of the clinical diagnosis. The diagnosis is made based on the presence of granulomas, multinucleated giant cells and acid fast bacilli on the skin biopsy.
January 1999: Singapore Medical Journal
D Ayache, P Rocher, A Buzyn-Veil, P Roulleau
Kikuchi's disease is rare necrotic histiocytosis of the lymph nodes. Since the first description in Japan in 1972 by Kikuchi, several cases have been reported. The disease occurs most frequently in young women. Manifestations include enlargement of the cervical lymph nodes, sometimes with fever, and often associated with other non-specific clinical signs. Blood chemistry, including immunologic tests, are often normal but neutropenia and raised erythrocyte sedimentation rate have been reported. Diagnosis relies on the histological examination of lymph node biopsies...
1993: Annales D'oto-laryngologie et de Chirurgie Cervico Faciale
V Baudinet, J Mauhin, A Reginster
No abstract text is available yet for this article.
May 1966: Acta Tuberculosea et Pneumologica Belgica
Z Kubiak, M Ratajek
No abstract text is available yet for this article.
April 1970: Gruźlica i Choroby Płuc; Tuberculosis et Pneumonologia
A N Lomkin
No abstract text is available yet for this article.
1967: Vestnik Akademii Meditsinskikh Nauk SSSR
O M Folomeeva
No abstract text is available yet for this article.
January 1978: Medit︠s︡inskai︠a︡ Sestra
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