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https://www.readbyqxmd.com/read/29049131/comparison-of-surgical-outcomes-narcotics-utilization-and-costs-after-an-anterior-cervical-discectomy-and-fusion-stand-alone-cage-versus-anterior-plating
#1
Ehsan Tabaraee, Junyoung Ahn, Daniel D Bohl, Michael J Collins, Dustin H Massel, Khaled Aboushaala, Kern Singh
STUDY DESIGN: Retrospective cohort analysis of a prospectively maintained registry. OBJECTIVE: To compare the surgical outcomes, narcotic utilization, and costs between a stand-alone (SA) cage and anterior plating (AP) with an interbody device for 1-level anterior cervical discectomy and fusion (ACDF). BACKGROUND DATA: ACDF with a SA cage has gained popularity as a potential alternative to anterior cervical plating. Few studies have compared the surgical outcomes, narcotic utilization, and costs of ACDF utilizing a SA cage versus AP with an interbody device...
November 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28989077/comparison-of-efficiencies-of-selected-sample-extraction-techniques-for-the-analysis-of-selected-antiretroviral-drugs-in-human-plasma-using-lc-ms
#2
Kwenga Sichilongo, Elliott Mwando, Enoch Sepako, Amos Massele
INTRODUCTION: Sample preparation in bio analytical chemistry poses a challenge because it can be compound dependent. We compared six sample extraction techniques i.e. QuEChERS (Q), liquid extraction (LE), protein precipitation (PPT), Q-PPT, Q-LE and LE-PPT for the extraction of antiretroviral drugs emtricitabine, tenofovir, efavirenz, lopinavir and rotinavir in human blood plasma. METHOD: A multiple reaction monitoring liquid chromatography- tandem mass spectrometry method for the determination of the same antiretroviral drugs developed and validated in this laboratory was used...
October 5, 2017: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/28922959/compliance-to-the-primary-health-care-treatment-guidelines-and-the-essential-medicines-list-in-the-management-of-sexually-transmitted-infections-in-correctional-centres-in-south-africa-findings-and-implications
#3
Tammy B Matsitse, Elvera Helberg, Johanna C Meyer, Brian Godman, Amos Massele, Natalie Schellack
BACKGROUND: The emergence of antimicrobial resistance (AMR) is a global concern and a growing health crisis. Additionally, evidence has shown that non-compliance to treatment guidelines, especially in the management of communicable diseases such as sexually transmitted infections (STIs), has the potential of further enhancing AMR rates. Data on the extent of these challenges in Primary Health Care (PHC) facilities in correctional centres in South Africa (SA) is limited. Hence this study was conducted to determine the level of compliance with the 2008 PHC Standard Treatment Guidelines and Essential Medicines List (PHC STGs/EML) in the management of STIs, and to identify potential factors contributing to the compliance and non-compliance to guide future strategies...
September 19, 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/28857969/assessing-online-patient-education-readability-for-spine-surgery-procedures
#4
William W Long, Krishna D Modi, Brittany E Haws, Benjamin Khechen, Dustin H Massel, Benjamin C Mayo, Kern Singh
BACKGROUND CONTEXT: Increased patient reliance on Internet-based health information has amplified the need for comprehensible online patient education articles. As suggested by the American Medical Association and National Institute of Health, spine fusion articles should be written for a 4th-6th-grade reading level to increase patient comprehension, which may improve postoperative outcomes. PURPOSE: The purpose of this study is to determine the readability of online health care education information relating to anterior cervical discectomy and fusion (ACDF) and lumbar fusion procedures...
August 28, 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28831829/prescription-patterns-and-adequacy-of-blood-pressure-control-among-adult-hypertensive-patients-in-kenya-findings-and-implications
#5
Jennifer M Mbui, Margaret N Oluka, Eric M Guantai, Kipruto A Sinei, Loice Achieng, Amanj Baker, Mary Jande, Amos Massele, Brian Godman
BACKGROUND: Hypertension is a major cause of global morbidity and mortality, with high prevalence rates in Africa including Kenya. Consequently, it is imperative to understand current treatment approaches and their effectiveness in practice. Currently, there is paucity of such data in Kenya, which is a concern. The aim is to describe prescribing patterns and adequacy of blood pressure (BP) control in adult hypertensive patients to guide future practice. METHOD: Retrospective study of patients attending a sub-county outpatient clinic combined with qualitative interviews...
November 2017: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/28827308/properties-of-a-family-56-carbohydrate-binding-module-and-its-role-in-the-recognition-and-hydrolysis-of-%C3%AE-1-3-glucan
#6
Andrew Hettle, Alexander Fillo, Kento Abe, Patricia Massel, Benjamin Pluvinage, David N Langelaan, Steven P Smith, Alisdair B Boraston
BH0236 from Bacillus halodurans is a multimodular β-1,3-glucanase comprising an N-terminal family 81 glycoside hydrolase catalytic module, an internal family 6 carbohydrate-binding module (CBM) that binds the nonreducing end of β-1,3-glucan chains, and an uncharacterized C-terminal module classified into CBM family 56. Here, we determined that this latter CBM, BhCBM56, bound the soluble β-1,3-glucan laminarin with a dissociation constant (Kd ) of ∼26 μm and displayed higher affinity for insoluble β-1,3-glucans with Kd values of ∼2-10 μm but lacked affinity for β-1,3-glucooligosaccharides...
October 13, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28781080/structural-analysis-of-a-family-81-glycoside-hydrolase-implicates-its-recognition-of-%C3%AE-1-3-glucan-quaternary-structure
#7
Benjamin Pluvinage, Alexander Fillo, Patricia Massel, Alisdair B Boraston
Family 81 glycoside hydrolases (GHs), which are known to cleave β-1,3-glucans, are found in archaea, bacteria, eukaryotes, and viruses. Here we examine the structural and functional features of the GH81 catalytic module, BhGH81, from the Bacillus halodurans protein BH0236 to probe the molecular basis of β-1,3-glucan recognition and cleavage. BhGH81 displayed activity on laminarin, curdlan, and pachyman, but not scleroglucan; the enzyme also cleaved β-1,3-glucooligosaccharides as small as β-1,3-glucotriose...
September 5, 2017: Structure
https://www.readbyqxmd.com/read/28627939/off-label-prescribing-for-children-with-chronic-diseases-in-nigeria-findings-and-implications
#8
Kazeem Adeola Oshikoya, Ibrahim Adekunle Oreagba, Brian Godman, Joseph Fadare, Samuel Orubu, Amos Massele, Idowu Odunayo Senbanjo
BACKGROUND: Prescribing medicines in an off-label manner for children with chronic conditions is sparsely documented, even more so among developing countries. This needs addressing. The objective of this research was to investigate the extent of off-label prescribing among children with epilepsy, asthma, and sickle cell anaemia in Nigeria. METHODS: Prescriptions for children ≤16 years documented in their case files that attended paediatric clinics in Lagos, Nigeria, for these three conditions between January and October 2015, were reviewed retrospectively to extract data on the medicines prescribed...
September 2017: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/28594516/lumbar-spine-injuries-in-the-athlete
#9
Dustin H Massel, Kern Singh
Low back pain is the most common complaint expressed by adult patients in the primary care setting, and the incidence of low back pain in adolescents is rising. Adolescents who are involved in athletics most commonly suffer from spondylolysis, spondylolisthesis, mechanical low back pain, and herniated disks, whereas adult athletes most commonly suffer from lumbosacral strain and herniated or degenerative disks. Initial nonsurgical management aims to reduce inflammation and noninvasively strengthen damaged tissues...
February 15, 2017: Instructional Course Lectures
https://www.readbyqxmd.com/read/28495309/group-ii-introns-in-wheat-mitochondria-have-degenerate-structural-features-and-varied-splicing-pathways
#10
Matthew Ngu, Karen Massel, Linda Bonen
Mitochondrial introns in flowering plant genes are virtually all classified as members of the group II ribozyme family although certain structural features have degenerated to varying degrees over evolutionary time. We are interested in the impact that unconventional intron architecture might have on splicing biochemistry in vivo and we have focused in particular on intronic domains V and VI, which for self-splicing introns provide a key component of the catalytic core and the bulged branchpoint adenosine, respectively...
October 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/28485175/patient-related-beliefs-and-adherence-toward-their-medications-among-the-adult-hypertensive-outpatients-in-tanzania
#11
Mary Jande, Deogratias M Katabalo, Praveen Sravanam, Carol Marwa, Bijal Madlan, Johanita Burger, Brian Godman, Margaret Oluka, Amos Massele, Stanley Mwita
AIM: Hypertension is a leading global health problem requiring lifelong treatment. However, adherence to antihypertensive medicines is a problem, greater among developing countries. Consequently, there is a need to determine current adherence rates and their associations among developing countries to plan future initiatives. MATERIALS & METHODS: Cross-sectional study among adult outpatients with essential hypertension in Tanzania. Predesigned questionnaires were used to gather information on adherence rates and patient-related beliefs...
May 9, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28339232/noiseless-quantum-measurement-and-squeezing-of-microwave-fields-utilizing-mechanical-vibrations
#12
C F Ockeloen-Korppi, E Damskägg, J-M Pirkkalainen, T T Heikkilä, F Massel, M A Sillanpää
A process which strongly amplifies both quadrature amplitudes of an oscillatory signal necessarily adds noise. Alternatively, if the information in one quadrature is lost in phase-sensitive amplification, it is possible to completely reconstruct the other quadrature. Here we demonstrate such a nearly perfect phase-sensitive measurement using a cavity optomechanical scheme, characterized by an extremely small noise less than 0.2 quanta. The device also strongly squeezes microwave radiation by 8 dB below vacuum...
March 10, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28228661/feasibility-of-an-exercise-intervention-for-fatigued-breast-cancer-patients-at-a-community-based-cardiac-rehabilitation-program
#13
Stefanie De Jesus, Lyndsay Fitzgeorge, Karen Unsworth, David Massel, Neville Suskin, Harry Prapavessis, Michael Sanatani
PURPOSE: Exercise is beneficial to quality of life after cancer treatment, yet few cancer survivors meet exercise guidelines. Our study sought to determine the feasibility of an oncology rehabilitation exercise program embedded within a cardiac rehabilitation program. METHODS: Patients who rated their fatigue >4/10 after completion of adjuvant chemotherapy for breast cancer were screened for eligibility and the outcomes were assessed (Piper Fatigue Scale, Functional Assessment of Cancer Therapy-Breast [FACT-B], Edmonton Symptom Assessment System, body composition, stress test, and physical activity measurement [accelerometer])...
2017: Cancer Management and Research
https://www.readbyqxmd.com/read/28219321/genetic-characterization-of-vibrio-cholerae-o1-isolates-from-outbreaks-between-2011-and-2015-in-tanzania
#14
Yazid Kachwamba, A A Mohammed, H Lukupulo, L Urio, M Majigo, F Mosha, M Matonya, R Kishimba, J Mghamba, J Lusekelo, S Nyanga, M Almeida, S Li, D Domman, S Y Massele, O C Stine
BACKGROUND: Cholera outbreaks have occurred in Tanzania since 1974. To date, the genetic epidemiology of these outbreaks has not been assessed. METHODS: 96 Vibrio cholerae O1 isolates from five regions were characterized, and their genetic relatedness assessed using multi-locus variable-number tandem-repeat analysis (MLVA) and whole genome sequencing (WGS). RESULTS: Of the 48 MLVA genotypes observed, 3 were genetically unrelated to any others, while the remaining 45 genotypes separated into three MLVA clonal complexes (CCs) - each comprised of genotypes differing by a single allelic change...
February 20, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28207667/differences-in-short-term-outcomes-between-primary-and-revision-anterior-cervical-discectomy-and-fusion
#15
Bryce A Basques, Nathaniel T Ondeck, Erik J Geiger, Andre M Samuel, Adam M Lukasiewicz, Matthew L Webb, Daniel D Bohl, Dustin H Massel, Benjamin C Mayo, Kern Singh, Jonathan N Grauer
STUDY DESIGN: Retrospective cohort study. OBJECTIVE: To compare short-term morbidity for primary and revision anterior cervical discectomy and fusion (ACDF). SUMMARY OF BACKGROUND DATA: Revision ACDF procedures are relatively common, yet their risks are poorly characterized in the literature. There is a need to assess the relative risk of revision ACDF procedures compared with primary surgery. METHODS: The prospectively collected American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database was used to identify patients who underwent primary and revision ACDF from 2005 to 2014...
February 15, 2017: Spine
https://www.readbyqxmd.com/read/28032428/antimalarial-treatment-patterns-among-pregnant-women-attending-antenatal-care-clinics-in-south-east-nigeria-and-the-future-implications
#16
Charles Ezenduka, Chizoba Nworgu, Brian Barr Godman, Amos Massele, Charles Esimone
BACKGROUND: Prompt and effective treatment of malaria in pregnancy in accordance with recommended guidelines is essential to help prevent adverse events among pregnant mothers and the foetus. AIM: The aim of this study was to assess current prescribing of antimalarial medicines in pregnancy against policy guidelines in south east Nigeria to provide future guidance. METHODS: A review of prescription records of pregnant women treated for malaria over a 6-month period between August 2013 and January 2014 was carried out to assess the prescribing patterns for both the prevention and treatment of malaria in each trimester and analyzed for conformity to recommended guidelines...
December 2016: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/27956726/effect-of-surgery-start-time-on-day-of-discharge-in-anterior-cervical-discectomy-and-fusion-patients
#17
Benjamin C Mayo, Dustin H Massel, Daniel D Bohl, William W Long, Krishna D Modi, Kern Singh
STUDY DESIGN: Retrospective cohort. OBJECTIVE: To compare time to discharge for anterior cervical discectomy and fusions (ACDF) when performed as either a first case versus later surgical start times. SUMMARY OF BACKGROUND DATA: ACDF is a commonly performed spinal procedure that typically has a short acute recovery period. With an increasing focus on reducing hospital costs and a shift toward outpatient surgical practices, early patient discharge has become a priority for hospitals and physicians alike...
December 15, 2016: Spine
https://www.readbyqxmd.com/read/27879573/multimodal-analgesia-versus-intravenous-patient-controlled-analgesia-for-minimally-invasive-transforaminal-lumbar-interbody-fusion-procedures
#18
Kern Singh, Daniel D Bohl, Junyoung Ahn, Dustin H Massel, Benjamin C Mayo, Ankur S Narain, Fady Y Hijji, Philip K Louie, William W Long, Krishna D Modi, Tae D Kim, Krishna T Kudaravalli, Frank M Phillips, Asokumar Buvanendran
STUDY DESIGN: Retrospective analysis. OBJECTIVE: To compare postoperative narcotic consumption and pain scores between multimodal analgesia (MMA) and patient-controlled analgesia (PCA) following minimally invasive transforaminal lumbar interbody fusion (MIS TLIF). SUMMARY OF BACKGROUND DATA: A multimodal analgesic approach to pain management may lead to decreased pain and narcotic consumption after orthopedic procedures. Additional evidence is, however, required to determine how MMA compares to intravenous PCA after MIS TLIF...
August 1, 2017: Spine
https://www.readbyqxmd.com/read/27875417/the-utility-of-routinely-obtaining-postoperative-laboratory-studies-following-a-minimally-invasive-transforaminal-lumbar-interbody-fusion
#19
Junyoung Ahn, Dustin H Massel, Benjamin C Mayo, Fady Y Hijji, Ankur S Narain, Khaled Aboushaala, Daniel D Bohl, Islam M Elboghdady, Jacob V DiBattista, Kern Singh
STUDY DESIGN: This is a retrospective analysis. OBJECTIVE: To test the hypothesis that there is limited utility in routinely obtaining postoperative laboratory values following minimally invasive transforaminal lumbar interbody fusion (MIS TLIF). BACKGROUND DATA: At many institutions, it is routine to obtain a complete blood count and basic metabolic profile (BMP) following a MIS TLIF. However, the utility of this practice has not been well characterized...
November 21, 2016: Clinical Spine Surgery
https://www.readbyqxmd.com/read/27875412/preoperative-mental-health-is-not-predictive-of-patient-reported-outcomes-following-a-minimally-invasive-lumbar-discectomy
#20
Benjamin C Mayo, Dustin H Massel, Daniel D Bohl, William W Long, Krishna D Modi, Ankur S Narain, Fady Y Hijji, Gregory Lopez, Kern Singh
STUDY DESIGN: This is a retrospective cohort study. OBJECTIVE: To determine if preoperative mental health is associated with patient-reported outcomes (PROs) following a minimally invasive lumbar discectomy. SUMMARY OF BACKGROUND DATA: PROs are commonly used to quantify a patient's perceived health status. Recently, mental health has been theorized to directly affect patients' perception of their disability and pain after spine surgery. MATERIALS AND METHODS: A registry of patients who underwent a primary, single-level minimally invasive lumbar discectomy was reviewed...
November 21, 2016: Clinical Spine Surgery
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