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https://www.readbyqxmd.com/read/28627939/off-label-prescribing-for-children-with-chronic-diseases-in-nigeria-findings-and-implications
#1
Kazeem Adeola Oshikoya, Ibrahim Adekunle Oreagba, Brian Godman, Joseph Fadare, Samuel Orubu, Amos Massele, Idowu Odunayo Senbanjo
BACKGROUND AND AIMS: Prescribing medicines in an off-label manner for children with chronic conditions is sparsely documented, even more so among developing countries. This needs addressing. The objective was to investigate the extent of this prescribing among children with epilepsy, asthma, and sickle cell anaemia in Nigeria. METHODS: Prescriptions for children ≤16 years documented in their case files that attended paediatric clinics in Lagos, Nigeria, for these three conditions between January and October 2015, were reviewed retrospectively to extract data on the medicines prescribed...
June 19, 2017: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/28594516/lumbar-spine-injuries-in-the-athlete
#2
Dustin H Massel, Kern Singh
Low back pain is the most common complaint expressed by adult patients in the primary care setting, and the incidence of low back pain in adolescents is rising. Adolescents who are involved in athletics most commonly suffer from spondylolysis, spondylolisthesis, mechanical low back pain, and herniated disks, whereas adult athletes most commonly suffer from lumbosacral strain and herniated or degenerative disks. Initial nonsurgical management aims to reduce inflammation and noninvasively strengthen damaged tissues...
February 15, 2017: Instructional Course Lectures
https://www.readbyqxmd.com/read/28495309/group-ii-introns-in-wheat-mitochondria-have-degenerate-structural-features-and-varied-splicing-pathways
#3
Matthew Ngu, Karen Massel, Linda Bonen
Mitochondrial introns in flowering plant genes are virtually all classified as members of the group II ribozyme family although certain structural features have degenerated to varying degrees over evolutionary time. We are interested in the impact that unconventional intron architecture might have on splicing biochemistry in vivo and we have focused in particular on intronic domains V and VI, which for self-splicing introns provide a key component of the catalytic core and the bulged branchpoint adenosine, respectively...
May 8, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/28485175/patient-related-beliefs-and-adherence-toward-their-medications-among-the-adult-hypertensive-outpatients-in-tanzania
#4
Mary Jande, Deogratias M Katabalo, Praveen Sravanam, Carol Marwa, Bijal Madlan, Johanita Burger, Brian Godman, Margaret Oluka, Amos Massele, Stanley Mwita
AIM: Hypertension is a leading global health problem requiring lifelong treatment. However, adherence to antihypertensive medicines is a problem, greater among developing countries. Consequently, there is a need to determine current adherence rates and their associations among developing countries to plan future initiatives. MATERIALS & METHODS: Cross-sectional study among adult outpatients with essential hypertension in Tanzania. Predesigned questionnaires were used to gather information on adherence rates and patient-related beliefs...
May 9, 2017: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/28339232/noiseless-quantum-measurement-and-squeezing-of-microwave-fields-utilizing-mechanical-vibrations
#5
C F Ockeloen-Korppi, E Damskägg, J-M Pirkkalainen, T T Heikkilä, F Massel, M A Sillanpää
A process which strongly amplifies both quadrature amplitudes of an oscillatory signal necessarily adds noise. Alternatively, if the information in one quadrature is lost in phase-sensitive amplification, it is possible to completely reconstruct the other quadrature. Here we demonstrate such a nearly perfect phase-sensitive measurement using a cavity optomechanical scheme, characterized by an extremely small noise less than 0.2 quanta. The device also strongly squeezes microwave radiation by 8 dB below vacuum...
March 10, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28228661/feasibility-of-an-exercise-intervention-for-fatigued-breast-cancer-patients-at-a-community-based-cardiac-rehabilitation-program
#6
Stefanie De Jesus, Lyndsay Fitzgeorge, Karen Unsworth, David Massel, Neville Suskin, Harry Prapavessis, Michael Sanatani
PURPOSE: Exercise is beneficial to quality of life after cancer treatment, yet few cancer survivors meet exercise guidelines. Our study sought to determine the feasibility of an oncology rehabilitation exercise program embedded within a cardiac rehabilitation program. METHODS: Patients who rated their fatigue >4/10 after completion of adjuvant chemotherapy for breast cancer were screened for eligibility and the outcomes were assessed (Piper Fatigue Scale, Functional Assessment of Cancer Therapy-Breast [FACT-B], Edmonton Symptom Assessment System, body composition, stress test, and physical activity measurement [accelerometer])...
2017: Cancer Management and Research
https://www.readbyqxmd.com/read/28219321/genetic-characterization-of-vibrio-cholerae-o1-isolates-from-outbreaks-between-2011-and-2015-in-tanzania
#7
Yazid Kachwamba, A A Mohammed, H Lukupulo, L Urio, M Majigo, F Mosha, M Matonya, R Kishimba, J Mghamba, J Lusekelo, S Nyanga, M Almeida, S Li, D Domman, S Y Massele, O C Stine
BACKGROUND: Cholera outbreaks have occurred in Tanzania since 1974. To date, the genetic epidemiology of these outbreaks has not been assessed. METHODS: 96 Vibrio cholerae O1 isolates from five regions were characterized, and their genetic relatedness assessed using multi-locus variable-number tandem-repeat analysis (MLVA) and whole genome sequencing (WGS). RESULTS: Of the 48 MLVA genotypes observed, 3 were genetically unrelated to any others, while the remaining 45 genotypes separated into three MLVA clonal complexes (CCs) - each comprised of genotypes differing by a single allelic change...
February 20, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28207667/differences-in-short-term-outcomes-between-primary-and-revision-anterior-cervical-discectomy-and-fusion
#8
Bryce A Basques, Nathaniel T Ondeck, Erik J Geiger, Andre M Samuel, Adam M Lukasiewicz, Matthew L Webb, Daniel D Bohl, Dustin H Massel, Benjamin C Mayo, Kern Singh, Jonathan N Grauer
STUDY DESIGN: Retrospective cohort study. OBJECTIVE: To compare short-term morbidity for primary and revision anterior cervical discectomy and fusion (ACDF). SUMMARY OF BACKGROUND DATA: Revision ACDF procedures are relatively common, yet their risks are poorly characterized in the literature. There is a need to assess the relative risk of revision ACDF procedures compared with primary surgery. METHODS: The prospectively collected American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database was used to identify patients who underwent primary and revision ACDF from 2005 to 2014...
February 15, 2017: Spine
https://www.readbyqxmd.com/read/28032428/antimalarial-treatment-patterns-among-pregnant-women-attending-antenatal-care-clinics-in-south-east-nigeria-and-the-future-implications
#9
Charles Ezenduka, Chizoba Nworgu, Brian Barr Godman, Amos Massele, Charles Esimone
BACKGROUND: Prompt and effective treatment of malaria in pregnancy in accordance with recommended guidelines is essential to help prevent adverse events among pregnant mothers and the foetus. AIM: The aim of this study was to assess current prescribing of antimalarial medicines in pregnancy against policy guidelines in south east Nigeria to provide future guidance. METHODS: A review of prescription records of pregnant women treated for malaria over a 6-month period between August 2013 and January 2014 was carried out to assess the prescribing patterns for both the prevention and treatment of malaria in each trimester and analyzed for conformity to recommended guidelines...
December 2016: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/27956726/effect-of-surgery-start-time-on-day-of-discharge-in-anterior-cervical-discectomy-and-fusion-patients
#10
Benjamin C Mayo, Dustin H Massel, Daniel D Bohl, William W Long, Krishna D Modi, Kern Singh
STUDY DESIGN: Retrospective cohort. OBJECTIVE: To compare time to discharge for anterior cervical discectomy and fusions (ACDF) when performed as either a first case versus later surgical start times. SUMMARY OF BACKGROUND DATA: ACDF is a commonly performed spinal procedure that typically has a short acute recovery period. With an increasing focus on reducing hospital costs and a shift toward outpatient surgical practices, early patient discharge has become a priority for hospitals and physicians alike...
December 15, 2016: Spine
https://www.readbyqxmd.com/read/27879573/multimodal-analgesia-versus-intravenous-patient-controlled-analgesia-for-minimally-invasive-transforaminal-lumbar-interbody-fusion-procedures
#11
Kern Singh, Daniel D Bohl, Junyoung Ahn, Dustin H Massel, Benjamin C Mayo, Ankur S Narain, Fady Y Hijji, Philip K Louie, William W Long, Krishna D Modi, Tae D Kim, Krishna T Kudaravalli, Frank M Phillips, Asokumar Buvanendran
STUDY DESIGN: Retrospective analysis. OBJECTIVE: To compare postoperative narcotic consumption and pain scores between multimodal analgesia (MMA) and patient-controlled analgesia (PCA) following minimally invasive transforaminal lumbar interbody fusion (MIS TLIF). SUMMARY OF BACKGROUND DATA: A multimodal analgesic approach to pain management may lead to decreased pain and narcotic consumption following orthopaedic procedures. However, additional evidence is required to determine how MMA compares to intravenous (IV) PCA following MIS TLIF...
November 22, 2016: Spine
https://www.readbyqxmd.com/read/27875417/the-utility-of-routinely-obtaining-postoperative-laboratory-studies-following-a-minimally-invasive-transforaminal-lumbar-interbody-fusion
#12
Junyoung Ahn, Dustin H Massel, Benjamin C Mayo, Fady Y Hijji, Ankur S Narain, Khaled Aboushaala, Daniel D Bohl, Islam M Elboghdady, Jacob V DiBattista, Kern Singh
STUDY DESIGN: This is a retrospective analysis. OBJECTIVE: To test the hypothesis that there is limited utility in routinely obtaining postoperative laboratory values following minimally invasive transforaminal lumbar interbody fusion (MIS TLIF). BACKGROUND DATA: At many institutions, it is routine to obtain a complete blood count and basic metabolic profile (BMP) following a MIS TLIF. However, the utility of this practice has not been well characterized...
November 21, 2016: Clinical Spine Surgery
https://www.readbyqxmd.com/read/27875412/preoperative-mental-health-is-not-predictive-of-patient-reported-outcomes-following-a-minimally-invasive-lumbar-discectomy
#13
Benjamin C Mayo, Dustin H Massel, Daniel D Bohl, William W Long, Krishna D Modi, Ankur S Narain, Fady Y Hijji, Gregory Lopez, Kern Singh
STUDY DESIGN: This is a retrospective cohort study. OBJECTIVE: To determine if preoperative mental health is associated with patient-reported outcomes (PROs) following a minimally invasive lumbar discectomy. SUMMARY OF BACKGROUND DATA: PROs are commonly used to quantify a patient's perceived health status. Recently, mental health has been theorized to directly affect patients' perception of their disability and pain after spine surgery. MATERIALS AND METHODS: A registry of patients who underwent a primary, single-level minimally invasive lumbar discectomy was reviewed...
November 21, 2016: Clinical Spine Surgery
https://www.readbyqxmd.com/read/27851659/improvements-in-neck-and-arm-pain-following-an-anterior-cervical-discectomy-and-fusion
#14
Dustin H Massel, Benjamin C Mayo, Daniel D Bohl, Ankur S Narain, Fady Y Hijji, Steven J Fineberg, Philip K Louie, Bryce A Basques, William W Long, Krishna D Modi, Kern Singh
STUDY DESIGN: Retrospective Analysis OBJECTIVE.: To quantify improvements in Visual Analogue Scale (VAS) neck and arm pain, Neck Disability Index (NDI), and Short Form-12 (SF-12) Mental (MCS) and Physical (PCS) Composite scores following an ACDF. SUMMARY OF BACKGROUND DATA: Anterior Cervical Discectomy and Fusion (ACDF) is evaluated with patient-reported outcomes. However, the extent to which these outcomes improve following ACDF remains poorly defined. METHODS: A surgical registry of patients who underwent primary, 1- or 2-level ACDF during 2013-2015 was reviewed...
November 15, 2016: Spine
https://www.readbyqxmd.com/read/27826302/whole-genome-sequencing-reveals-potential-new-targets-for-improving-nitrogen-uptake-and-utilization-in-sorghum-bicolor
#15
Karen Massel, Bradley C Campbell, Emma S Mace, Shuaishuai Tai, Yongfu Tao, Belinda G Worland, David R Jordan, Jose R Botella, Ian D Godwin
Nitrogen (N) fertilizers are a major agricultural input where more than 100 million tons are supplied annually. Cereals are particularly inefficient at soil N uptake, where the unrecovered nitrogen causes serious environmental damage. Sorghum bicolor (sorghum) is an important cereal crop, particularly in resource-poor semi-arid regions, and is known to have a high NUE in comparison to other major cereals under limited N conditions. This study provides the first assessment of genetic diversity and signatures of selection across 230 fully sequenced genes putatively involved in the uptake and utilization of N from a diverse panel of sorghum lines...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27809620/outcome-of-the-second-medicines-utilisation-research-in-africa-group-meeting-to-promote-sustainable-and-appropriate-medicine-use-in-africa
#16
Amos Massele, Johanita Burger, Francis Kalemeera, Mary Jande, Thatayaone Didimalang, Aubrey Chichonyi Kalungia, Kidwell Matshotyana, Michael Law, Brighid Malone, Olayinka Ogunleye, Margaret Oluka, Bene D Paramadhas, Godfrey Rwegerera, Sekesai Zinyowera, Brian Godman
The second Medicines Utilization Research in Africa (MURIA) group workshop and symposium again brought researchers together from across Africa to improve their knowledge of drug utilization (DU) methodologies and exchange ideas to further progress DU research in Africa. This built on extensive activities from the first conference including workshops and multiple publications. Anti-infectives were again the principal theme for the 2016 symposium following the workshops. This included presentations regarding strategies to improve antibiotic utilization among African countries, such as point-prevalence studies, as well as potential ways to reduce self-purchasing of antibiotics...
April 2017: Expert Review of Pharmacoeconomics & Outcomes Research
https://www.readbyqxmd.com/read/27779602/spinal-surgeon-variation-in-single-level-cervical-fusion-procedures-a-cost-and-hospital-resource-utilization-analysis
#17
Fady Y Hijji, Dustin H Massel, Benjamin C Mayo, Ankur S Narain, William W Long, Krishna D Modi, Rory M Burke, Jeff Canar, Kern Singh
STUDY DESIGN: Retrospective analysis. OBJECTIVE: To compare perioperative costs and outcomes of patients undergoing single-level anterior cervical discectomy and fusions (ACDF) at both a service (orthopedic versus neurosurgical) and individual surgeon level. SUMMARY OF BACKGROUND DATA: Hospital systems are experiencing significant pressure to increase value of care by reducing costs while maintaining or improving patient-centered outcomes...
October 24, 2016: Spine
https://www.readbyqxmd.com/read/27689424/preoperative-mental-health-status-may-not-be-predictive-of-improvements-in-patient-reported-outcomes-following-an-anterior-cervical-discectomy-and-fusion
#18
Benjamin C Mayo, Dustin H Massel, Daniel D Bohl, Ankur S Narain, Fady Y Hijji, William W Long, Krishna D Modi, Bryce A Basques, Alem Yacob, Kern Singh
OBJECTIVE Prior studies have correlated preoperative depression and poor mental health status with inferior patient-reported outcomes following lumbar spinal procedures. However, literature regarding the effect of mental health on outcomes following cervical spinal surgery is limited. As such, the purpose of this study is to test for the association of preoperative SF-12 Mental Component Summary (MCS) scores with improvements in Neck Disability Index (NDI), SF-12 Physical Component Summary (PCS), and neck and arm pain following anterior cervical discectomy and fusion (ACDF)...
February 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/27664337/patient-knowledge-regarding-radiation-exposure-from-spinal-imaging
#19
Daniel D Bohl, Fady Y Hijji, Dustin H Massel, Benjamin C Mayo, William W Long, Krishna D Modi, Ankur S Narain, Blaine T Manning, Junyoung Ahn, Philip K Louie, Kern Singh
BACKGROUND CONTEXT: Spine surgeons employ a high volume of imaging in the diagnosis and evaluation of spinal pathology. However, little is known regarding patients' knowledge of the radiation exposure associated with these imaging techniques. PURPOSE: To characterize spine patients' knowledge regarding radiation exposure from various imaging modalities. STUDY DESIGN/SETTING: A cross-sectional survey study. PATIENT SAMPLE: One hundred patients at their first clinic visit with a single spine surgeon at an urban institution...
September 21, 2016: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/27592636/potential-drug-drug-interactions-in-paediatric-outpatient-prescriptions-in-nigeria-and-implications-for-the-future
#20
MULTICENTER STUDY
Kazeem Adeola Oshikoya, Ibrahim Adekunle Oreagba, Brian Godman, Fisayo Solomon Oguntayo, Joseph Fadare, Samuel Orubu, Amos Massele, Idowu Odunayo Senbanjo
BACKGROUND: Information regarding the incidence of drug-drug interactions (DDIs) and adverse drug events (ADEs) among paediatric patients in Nigeria is limited. METHODS: Prospective clinical audit among paediatric outpatients in four general hospitals in Nigeria over a 3-month period. Details of ADEs documented in case files was extracted. RESULTS: Among 1233 eligible patients, 208 (16.9%) received prescriptions with at least one potential DDI...
November 2016: Expert Review of Clinical Pharmacology
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