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https://www.readbyqxmd.com/read/29695847/stabilized-entanglement-of-massive-mechanical-oscillators
#1
C F Ockeloen-Korppi, E Damskägg, J-M Pirkkalainen, M Asjad, A A Clerk, F Massel, M J Woolley, M A Sillanpää
Quantum entanglement is a phenomenon whereby systems cannot be described independently of each other, even though they may be separated by an arbitrarily large distance 1 . Entanglement has a solid theoretical and experimental foundation and is the key resource behind many emerging quantum technologies, including quantum computation, cryptography and metrology. Entanglement has been demonstrated for microscopic-scale systems, such as those involving photons2-5 , ions 6 and electron spins 7 , and more recently in microwave and electromechanical devices8-10 ...
April 2018: Nature
https://www.readbyqxmd.com/read/29672172/ongoing-initiatives-to-improve-the-use-of-antibiotics-in-botswana-university-of-botswana-symposium-meeting-report
#2
Celda Tiroyakgosi, Matshediso Matome, Emily Summers, Yohana Mashalla, Bene Anand Paramadhas, Sajini Souda, Brighid Malone, Fatima Sinkala, Joyce Kgatlwane, Brian Godman, Keneilwe Mmopi, Amos Massele
The objective of this meeting was to discuss ongoing initiatives in Botswana since February 2016 to improve antibiotic use. Subsequently, use the findings to refine national and local action plans. There was a high rate of antibiotic prescribing among ambulatory care patients in the public sector (42.7%) as well as for patients with URTIs in the private sector (72.9%). Prophylactic antibiotics were given to 73.3% of surgical patients to reduce surgical site infections (SSIs) in a leading tertiary hospital in Botswana; however, SSIs at 9% of patients can be reduced further with better timing of antibiotic prophylaxis...
April 19, 2018: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/29628713/rotator-cuff-tears-in-the-pediatric-population-comparing-findings-on-arthroscopic-evaluation-to-pre-operative-magnetic-resonance-imaging
#3
Jose R Perez, Dustin Massel, Carlos M Barrera, Michael G Baraga, Juan Pretell-Mazzini, Lee D Kaplan, Jean Jose
No abstract text is available yet for this article.
March 2018: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/29619275/operative-trends-in-the-treatment-of-hip-fractures-and-the-role-of-arthroplasty
#4
Luis Grau, Spencer Summers, Dustin H Massel, Samuel Rosas, Alvin Ong, Victor Hugo Hernandez
Introduction: There is a projected exponential increase in the number of hip fractures in the United States. Trends in patient demographics and the role of total hip arthroplasty (THA) and its associated outcomes following hip fractures surgery have not been well studied. Methods: Patients with proximal femur fractures between 1990 and 2007 were identified in the National Hospital Discharge Survey database. Demographics, comorbidities, perioperative complications, and discharge status for patients undergoing THA, hemiarthroplasty, or internal fixation were examined...
2018: Geriatric Orthopaedic Surgery & Rehabilitation
https://www.readbyqxmd.com/read/29521136/prophylactic-antibiotics-to-prevent-surgical-site-infections-in-botswana-findings-and-implications
#5
Julius C Mwita, Sajini Souda, Mgaywa G M D Magafu, Amos Massele, Brian Godman, Michael Mwandri
OBJECTIVES: Antibiotic prophylaxis in surgery is known to reduce the rate of surgical site infections (SSI) as well as shorten hospital stay. However, there is currently a scarcity of data on antibiotic prophylaxis and SSIs among African countries including Botswana. Consequently, this study aimed to address this. METHODS: A prospective study involving 400 patients was carried out at a leading tertiary hospital in Botswana from 2014-2015. Patients' demographic information, type of surgery performed and peri-operative use of antibiotics were documented...
March 23, 2018: Hospital Practice (Minneapolis)
https://www.readbyqxmd.com/read/29461536/oxygen-redox-chemistry-without-excess-alkali-metal-ions-in-na-2-3-mg-0-28-mn-0-72-o-2
#6
Urmimala Maitra, Robert A House, James W Somerville, Nuria Tapia-Ruiz, Juan G Lozano, Niccoló Guerrini, Rong Hao, Kun Luo, Liyu Jin, Miguel A Pérez-Osorio, Felix Massel, David M Pickup, Silvia Ramos, Xingye Lu, Daniel E McNally, Alan V Chadwick, Feliciano Giustino, Thorsten Schmitt, Laurent C Duda, Matthew R Roberts, Peter G Bruce
The search for improved energy-storage materials has revealed Li- and Na-rich intercalation compounds as promising high-capacity cathodes. They exhibit capacities in excess of what would be expected from alkali-ion removal/reinsertion and charge compensation by transition-metal (TM) ions. The additional capacity is provided through charge compensation by oxygen redox chemistry and some oxygen loss. It has been reported previously that oxygen redox occurs in O 2p orbitals that interact with alkali ions in the TM and alkali-ion layers (that is, oxygen redox occurs in compounds containing Li+ -O(2p)-Li+ interactions)...
March 2018: Nature Chemistry
https://www.readbyqxmd.com/read/29426263/drug-promotional-activities-in-nigeria-impact-on-the-prescribing-patterns-and-practices-of-medical-practitioners-and-the-implications
#7
Joseph O Fadare, Kazeem A Oshikoya, Olayinka O Ogunleye, Olufemi O Desalu, Alessandra Ferrario, Okezie O Enwere, Adekunle Adeoti, Taofiki A Sunmonu, Amos Massele, Amanj Baker, Brian Godman
OBJECTIVE: Pharmaceutical companies spend significant amount of resources on promotion influencing the prescribing behavior of physicians. Drug promotion can negatively impact on rational prescribing, which may adversely affect the quality of patient care. However, little is known about these activities in Nigeria as the most populous country in Africa. We therefore aimed to explore the nature of encounters between Nigerian physicians and pharmaceutical sales representatives (PSRs), and how these encounters influence prescribing habits...
April 2018: Hospital Practice (Minneapolis)
https://www.readbyqxmd.com/read/29410212/orthopedic-injuries-associated-with-jet-skis-personal-watercrafts-a-review-of-127-inpatients
#8
C J Donnally, P M Rothenberg, G Metser, D H Massel, A J Butler, D Damodar, S H Shin, T L Zakrison
BACKGROUND: Personal watercrafts (PWC) account for a disproportionate amount of water based injuries. Current literature suggests those with less PWC experience are more at risk for injury. Previous studies have not specifically evaluated the orthopedic implications of PWC usage or how various mechanisms of injury (MOI) contribute to different injury patterns. HYPOTHESIS: PWC injuries will frequently require orthopedic intervention. The presence of an orthopedic injury will result in increased injury severity score (ISS), hospital and intensive care unit (ICU) length of stay (LOS)...
April 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29356800/opioid-use-disorders-are-associated-with-perioperative-morbidity-and-mortality-in-the-hip-fracture-population
#9
Spencer Summers, Luis Grau, Dustin Massel, Samuel Rosas, Alvin Ong, Victor Hugo Hernandez
OBJECTIVES: To determine if opioid use disorders are associated with adverse perioperative outcomes in patients undergoing surgical fixation for proximal femur fractures. METHODS: The National Hospital Discharge Survey was queried to identify patients surgically treated for proximal femur fractures between 1990-2007. Patients were grouped into those with a diagnosis opioid use disorder (OUD), non-opioid drug use disorder (DUD), or neither. Demographic information and comorbidities were included in univariable and multivariable analyses to identify independent risk factors for perioperative outcomes...
January 5, 2018: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/29215497/gender-differences-for-anterior-cervical-fusion-complications-and-length-of-stay
#10
Bryce A Basques, Fady Y Hijji, Benjamin Khechen, Brittany E Haws, Benjamin C Mayo, Dustin H Massel, Philip K Louie, Kaitlyn L Cardinal, Jordan A Guntin, Kern Singh
STUDY DESIGN: Retrospective cohort OBJECTIVE.: To assess differences in baseline characteristics between genders of patients undergoing anterior cervical discectomy and fusion (ACDF) and risk factors for adverse outcomes according to gender. SUMMARY OF BACKGROUND DATA: ACDF is a common treatment for cervical spine disease. To reduce the rate of complications, risk factors associated for adverse events have been identified. However, few studies have examined the risk for inferior outcomes or complications following ACDF by gender...
December 5, 2017: Spine
https://www.readbyqxmd.com/read/29178350/assessment-of-prescribing-practices-at-the-primary-healthcare-facilities-in-botswana-with-an-emphasis-on-antibiotics-findings-and-implications
#11
Yohana Mashalla, Vincent Setlhare, Amos Massele, Enoch Sepako, Celda Tiroyakgosi, Joyce Kgatlwane, Mpo Chuma, Brian Godman
BACKGROUND AND AIMS: Inappropriate drug prescribing has increased especially in developing countries where systems for monitoring medicine use are not well developed. This increases the rate of antimicrobial resistance. The study aim was to assess the prescribing patterns among urban primary health facilities in Botswana to provide future guidance including developing future quality indicators. METHODS: Retrospective data from patients' records between January and December 2013 in 19 clinics were collected in a cross-sectional study...
December 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/29049131/comparison-of-surgical-outcomes-narcotics-utilization-and-costs-after-an-anterior-cervical-discectomy-and-fusion-stand-alone-cage-versus-anterior-plating
#12
Ehsan Tabaraee, Junyoung Ahn, Daniel D Bohl, Michael J Collins, Dustin H Massel, Khaled Aboushaala, Kern Singh
STUDY DESIGN: Retrospective cohort analysis of a prospectively maintained registry. OBJECTIVE: To compare the surgical outcomes, narcotic utilization, and costs between a stand-alone (SA) cage and anterior plating (AP) with an interbody device for 1-level anterior cervical discectomy and fusion (ACDF). BACKGROUND DATA: ACDF with a SA cage has gained popularity as a potential alternative to anterior cervical plating. Few studies have compared the surgical outcomes, narcotic utilization, and costs of ACDF utilizing a SA cage versus AP with an interbody device...
November 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28989077/comparison-of-efficiencies-of-selected-sample-extraction-techniques-for-the-analysis-of-selected-antiretroviral-drugs-in-human-plasma-using-lc-ms
#13
Kwenga Sichilongo, Elliott Mwando, Enoch Sepako, Amos Massele
INTRODUCTION: Sample preparation in bio analytical chemistry poses a challenge because it can be compound dependent. We compared six sample extraction techniques i.e. QuEChERS (Q), liquid extraction (LE), protein precipitation (PPT), Q-PPT, Q-LE and LE-PPT for the extraction of antiretroviral drugs emtricitabine, tenofovir, efavirenz, lopinavir and rotinavir in human blood plasma. METHOD: A multiple reaction monitoring liquid chromatography- tandem mass spectrometry method for the determination of the same antiretroviral drugs developed and validated in this laboratory was used...
January 2018: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/28922959/compliance-to-the-primary-health-care-treatment-guidelines-and-the-essential-medicines-list-in-the-management-of-sexually-transmitted-infections-in-correctional-centres-in-south-africa-findings-and-implications
#14
Tammy B Matsitse, Elvera Helberg, Johanna C Meyer, Brian Godman, Amos Massele, Natalie Schellack
BACKGROUND: The emergence of antimicrobial resistance (AMR) is a global concern and a growing health crisis. Additionally, evidence has shown that non-compliance to treatment guidelines, especially in the management of communicable diseases such as sexually transmitted infections (STIs), has the potential of further enhancing AMR rates. Data on the extent of these challenges in Primary Health Care (PHC) facilities in correctional centres in South Africa (SA) is limited. Hence this study was conducted to determine the level of compliance with the 2008 PHC Standard Treatment Guidelines and Essential Medicines List (PHC STGs/EML) in the management of STIs, and to identify potential factors contributing to the compliance and non-compliance to guide future strategies...
September 19, 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/28857969/assessing-online-patient-education-readability-for-spine-surgery-procedures
#15
William W Long, Krishna D Modi, Brittany E Haws, Benjamin Khechen, Dustin H Massel, Benjamin C Mayo, Kern Singh
BACKGROUND CONTEXT: Increased patient reliance on Internet-based health information has amplified the need for comprehensible online patient education articles. As suggested by the American Medical Association and National Institute of Health, spine fusion articles should be written for a 4th-6th-grade reading level to increase patient comprehension, which may improve postoperative outcomes. PURPOSE: The purpose of this study is to determine the readability of online health care education information relating to anterior cervical discectomy and fusion (ACDF) and lumbar fusion procedures...
March 2018: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28831829/prescription-patterns-and-adequacy-of-blood-pressure-control-among-adult-hypertensive-patients-in-kenya-findings-and-implications
#16
Jennifer M Mbui, Margaret N Oluka, Eric M Guantai, Kipruto A Sinei, Loice Achieng, Amanj Baker, Mary Jande, Amos Massele, Brian Godman
BACKGROUND: Hypertension is a major cause of global morbidity and mortality, with high prevalence rates in Africa including Kenya. Consequently, it is imperative to understand current treatment approaches and their effectiveness in practice. Currently, there is paucity of such data in Kenya, which is a concern. The aim is to describe prescribing patterns and adequacy of blood pressure (BP) control in adult hypertensive patients to guide future practice. METHOD: Retrospective study of patients attending a sub-county outpatient clinic combined with qualitative interviews...
November 2017: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/28827308/properties-of-a-family-56-carbohydrate-binding-module-and-its-role-in-the-recognition-and-hydrolysis-of-%C3%AE-1-3-glucan
#17
Andrew Hettle, Alexander Fillo, Kento Abe, Patricia Massel, Benjamin Pluvinage, David N Langelaan, Steven P Smith, Alisdair B Boraston
BH0236 from Bacillus halodurans is a multimodular β-1,3-glucanase comprising an N-terminal family 81 glycoside hydrolase catalytic module, an internal family 6 carbohydrate-binding module (CBM) that binds the nonreducing end of β-1,3-glucan chains, and an uncharacterized C-terminal module classified into CBM family 56. Here, we determined that this latter CBM, BhCBM56, bound the soluble β-1,3-glucan laminarin with a dissociation constant ( Kd ) of ∼26 μm and displayed higher affinity for insoluble β-1,3-glucans with Kd values of ∼2-10 μm but lacked affinity for β-1,3-glucooligosaccharides...
October 13, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28781080/structural-analysis-of-a-family-81-glycoside-hydrolase-implicates-its-recognition-of-%C3%AE-1-3-glucan-quaternary-structure
#18
Benjamin Pluvinage, Alexander Fillo, Patricia Massel, Alisdair B Boraston
Family 81 glycoside hydrolases (GHs), which are known to cleave β-1,3-glucans, are found in archaea, bacteria, eukaryotes, and viruses. Here we examine the structural and functional features of the GH81 catalytic module, BhGH81, from the Bacillus halodurans protein BH0236 to probe the molecular basis of β-1,3-glucan recognition and cleavage. BhGH81 displayed activity on laminarin, curdlan, and pachyman, but not scleroglucan; the enzyme also cleaved β-1,3-glucooligosaccharides as small as β-1,3-glucotriose...
September 5, 2017: Structure
https://www.readbyqxmd.com/read/28627939/off-label-prescribing-for-children-with-chronic-diseases-in-nigeria-findings-and-implications
#19
Kazeem Adeola Oshikoya, Ibrahim Adekunle Oreagba, Brian Godman, Joseph Fadare, Samuel Orubu, Amos Massele, Idowu Odunayo Senbanjo
BACKGROUND: Prescribing medicines in an off-label manner for children with chronic conditions is sparsely documented, even more so among developing countries. This needs addressing. The objective of this research was to investigate the extent of off-label prescribing among children with epilepsy, asthma, and sickle cell anaemia in Nigeria. METHODS: Prescriptions for children ≤16 years documented in their case files that attended paediatric clinics in Lagos, Nigeria, for these three conditions between January and October 2015, were reviewed retrospectively to extract data on the medicines prescribed...
September 2017: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/28594516/lumbar-spine-injuries-in-the-athlete
#20
Dustin H Massel, Kern Singh
Low back pain is the most common complaint expressed by adult patients in the primary care setting, and the incidence of low back pain in adolescents is rising. Adolescents who are involved in athletics most commonly suffer from spondylolysis, spondylolisthesis, mechanical low back pain, and herniated disks, whereas adult athletes most commonly suffer from lumbosacral strain and herniated or degenerative disks. Initial nonsurgical management aims to reduce inflammation and noninvasively strengthen damaged tissues...
February 15, 2017: Instructional Course Lectures
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