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https://www.readbyqxmd.com/read/27879573/multimodal-analgesia-versus-intravenous-patient-controlled-analgesia-for-minimally-invasive-transforaminal-lumbar-interbody-fusion-procedures
#1
Kern Singh, Daniel D Bohl, Junyoung Ahn, Dustin H Massel, Benjamin C Mayo, Ankur S Narain, Fady Y Hijji, Philip K Louie, William W Long, Krishna D Modi, Tae D Kim, Krishna T Kudaravalli, Frank M Phillips, Asokumar Buvanendran
STUDY DESIGN: Retrospective analysis. OBJECTIVE: To compare postoperative narcotic consumption and pain scores between multimodal analgesia (MMA) and patient-controlled analgesia (PCA) following minimally invasive transforaminal lumbar interbody fusion (MIS TLIF). SUMMARY OF BACKGROUND DATA: A multimodal analgesic approach to pain management may lead to decreased pain and narcotic consumption following orthopaedic procedures. However, additional evidence is required to determine how MMA compares to intravenous (IV) PCA following MIS TLIF...
November 22, 2016: Spine
https://www.readbyqxmd.com/read/27875417/the-utility-of-routinely-obtaining-postoperative-laboratory-studies-following-a-minimally-invasive-transforaminal-lumbar-interbody-fusion
#2
Junyoung Ahn, Dustin H Massel, Benjamin C Mayo, Fady Y Hijji, Ankur S Narain, Khaled Aboushaala, Daniel D Bohl, Islam M Elboghdady, Jacob V DiBattista, Kern Singh
STUDY DESIGN: This is a retrospective analysis. OBJECTIVE: To test the hypothesis that there is limited utility in routinely obtaining postoperative laboratory values following minimally invasive transforaminal lumbar interbody fusion (MIS TLIF). BACKGROUND DATA: At many institutions, it is routine to obtain a complete blood count and basic metabolic profile (BMP) following a MIS TLIF. However, the utility of this practice has not been well characterized...
November 21, 2016: Clinical Spine Surgery
https://www.readbyqxmd.com/read/27875412/preoperative-mental-health-is-not-predictive-of-patient-reported-outcomes-following-a-minimally-invasive-lumbar-discectomy
#3
Benjamin C Mayo, Dustin H Massel, Daniel D Bohl, William W Long, Krishna D Modi, Ankur S Narain, Fady Y Hijji, Gregory Lopez, Kern Singh
STUDY DESIGN: This is a retrospective cohort study. OBJECTIVE: To determine if preoperative mental health is associated with patient-reported outcomes (PROs) following a minimally invasive lumbar discectomy. SUMMARY OF BACKGROUND DATA: PROs are commonly used to quantify a patient's perceived health status. Recently, mental health has been theorized to directly affect patients' perception of their disability and pain after spine surgery. MATERIALS AND METHODS: A registry of patients who underwent a primary, single-level minimally invasive lumbar discectomy was reviewed...
November 21, 2016: Clinical Spine Surgery
https://www.readbyqxmd.com/read/27851659/improvements-in-neck-and-arm-pain-following-an-anterior-cervical-discectomy-and-fusion
#4
Dustin H Massel, Benjamin C Mayo, Daniel D Bohl, Ankur S Narain, Fady Y Hijji, Steven J Fineberg, Philip K Louie, Bryce A Basques, William W Long, Krishna D Modi, Kern Singh
STUDY DESIGN: Retrospective Analysis OBJECTIVE.: To quantify improvements in Visual Analogue Scale (VAS) neck and arm pain, Neck Disability Index (NDI), and Short Form-12 (SF-12) Mental (MCS) and Physical (PCS) Composite scores following an ACDF. SUMMARY OF BACKGROUND DATA: Anterior Cervical Discectomy and Fusion (ACDF) is evaluated with patient-reported outcomes. However, the extent to which these outcomes improve following ACDF remains poorly defined. METHODS: A surgical registry of patients who underwent primary, 1- or 2-level ACDF during 2013-2015 was reviewed...
November 15, 2016: Spine
https://www.readbyqxmd.com/read/27826302/whole-genome-sequencing-reveals-potential-new-targets-for-improving-nitrogen-uptake-and-utilization-in-sorghum-bicolor
#5
Karen Massel, Bradley C Campbell, Emma S Mace, Shuaishuai Tai, Yongfu Tao, Belinda G Worland, David R Jordan, Jose R Botella, Ian D Godwin
Nitrogen (N) fertilizers are a major agricultural input where more than 100 million tons are supplied annually. Cereals are particularly inefficient at soil N uptake, where the unrecovered nitrogen causes serious environmental damage. Sorghum bicolor (sorghum) is an important cereal crop, particularly in resource-poor semi-arid regions, and is known to have a high NUE in comparison to other major cereals under limited N conditions. This study provides the first assessment of genetic diversity and signatures of selection across 230 fully sequenced genes putatively involved in the uptake and utilization of N from a diverse panel of sorghum lines...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27809620/outcome-of-the-second-medicines-utilisation-research-in-africa-group-meeting-to-promote-sustainable-and-appropriate-medicine-use-in-africa
#6
Amos Massele, Johanita Burger, Francis Kalemeera, Mary Jande, Thatayaone Didimalang, Aubrey Chichonyi Kalungia, Kidwell Matshotyana, Michael Law, Brighid Malone, Olayinka Ogunleye, Margaret Oluka, Bene D Paramadhas, Godfrey Rwegerera, Sekesai Zinyowera, Brian Godman
The second Medicines Utilization Research in Africa (MURIA) group workshop and symposium again brought researchers together from across Africa to improve their knowledge of drug utilization (DU) methodologies and exchange ideas to further progress DU research in Africa. This built on extensive activities from the first conference including workshops and multiple publications. Anti-infectives were again the principal theme for the 2016 symposium following the workshops. This included presentations regarding strategies to improve antibiotic utilization among African countries, such as point-prevalence studies, as well as potential ways to reduce self-purchasing of antibiotics...
November 3, 2016: Expert Review of Pharmacoeconomics & Outcomes Research
https://www.readbyqxmd.com/read/27779602/spinal-surgeon-variation-in-single-level-cervical-fusion-procedures-a-cost-and-hospital-resource-utilization-analysis
#7
Fady Y Hijji, Dustin H Massel, Benjamin C Mayo, Ankur S Narain, William W Long, Krishna D Modi, Rory M Burke, Jeff Canar, Kern Singh
STUDY DESIGN: Retrospective analysis. OBJECTIVE: To compare perioperative costs and outcomes of patients undergoing single-level anterior cervical discectomy and fusions (ACDF) at both a service (orthopedic versus neurosurgical) and individual surgeon level. SUMMARY OF BACKGROUND DATA: Hospital systems are experiencing significant pressure to increase value of care by reducing costs while maintaining or improving patient-centered outcomes...
October 24, 2016: Spine
https://www.readbyqxmd.com/read/27689424/preoperative-mental-health-status-may-not-be-predictive-of-improvements-in-patient-reported-outcomes-following-an-anterior-cervical-discectomy-and-fusion
#8
Benjamin C Mayo, Dustin H Massel, Daniel D Bohl, Ankur S Narain, Fady Y Hijji, William W Long, Krishna D Modi, Bryce A Basques, Alem Yacob, Kern Singh
OBJECTIVE Prior studies have correlated preoperative depression and poor mental health status with inferior patient-reported outcomes following lumbar spinal procedures. However, literature regarding the effect of mental health on outcomes following cervical spinal surgery is limited. As such, the purpose of this study is to test for the association of preoperative SF-12 Mental Component Summary (MCS) scores with improvements in Neck Disability Index (NDI), SF-12 Physical Component Summary (PCS), and neck and arm pain following anterior cervical discectomy and fusion (ACDF)...
September 30, 2016: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/27664337/patient-knowledge-regarding-radiation-exposure-from-spinal-imaging
#9
Daniel D Bohl, Fady Y Hijji, Dustin H Massel, Benjamin C Mayo, William W Long, Krishna D Modi, Ankur S Narain, Blaine T Manning, Junyoung Ahn, Philip K Louie, Kern Singh
BACKGROUND CONTEXT: Spine surgeons employ a high volume of imaging in the diagnosis and evaluation of spinal pathology. However, little is known regarding patients' knowledge of the radiation exposure associated with these imaging techniques. PURPOSE: To characterize spine patients' knowledge regarding radiation exposure from various imaging modalities. STUDY DESIGN/SETTING: A cross-sectional survey study. PATIENT SAMPLE: One hundred patients at their first clinic visit with a single spine surgeon at an urban institution...
September 21, 2016: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/27592636/potential-drug-drug-interactions-in-paediatric-outpatient-prescriptions-in-nigeria-and-implications-for-the-future
#10
Kazeem Adeola Oshikoya, Ibrahim Adekunle Oreagba, Brian Godman, Fisayo Solomon Oguntayo, Joseph Fadare, Samuel Orubu, Amos Massele, Idowu Odunayo Senbanjo
BACKGROUND: Information regarding incidence of drug-drug interactions (DDIs) and adverse drug events (ADEs) among paediatric patients in Nigeria is limited. METHODS: Prospective clinical audit among paediatric outpatients in four general hospitals in Nigeria over a 3-month period. ADEs documented in case files extracted. RESULTS: Among 1233 eligible patients, 208 (16.9%) received prescriptions with at least one potential DDI. Seven drug classes were implicated with antimalarial combination therapies predominating...
September 3, 2016: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/27516740/introduction-and-utilization-of-high-priced-hcv-medicines-across-europe-implications-for-the-future
#11
Winnie de Bruijn, Cristina Ibáñez, Pia Frisk, Hanne Bak Pedersen, Ali Alkan, Patricia Vella Bonanno, Ljiljana S Brkičić, Anna Bucsics, Guillaume Dedet, Jaran Eriksen, Joseph O Fadare, Jurij Fürst, Gisselle Gallego, Isabella P Godói, Augusto A Guerra Júnior, Hakkı Gürsöz, Saira Jan, Jan Jones, Roberta Joppi, Saim Kerman, Ott Laius, Newman Madzikwa, Einar Magnússon, Mojca Maticic, Vanda Markovic-Pekovic, Amos Massele, Olayinka Ogunleye, Aisling O'Leary, Jutta Piessnegger, Catherine Sermet, Steven Simoens, Celda Tiroyakgosi, Ilse Truter, Magnus Thyberg, Kristina Tomekova, Magdalena Wladysiuk, Sotiris Vandoros, Elif H Vural, Corinne Zara, Brian Godman
BACKGROUND: Infection with the Hepatitis C Virus (HCV) is a widespread transmittable disease with a diagnosed prevalence of 2.0%. Fortunately, it is now curable in most patients. Sales of medicines to treat HCV infection grew 2.7% per year between 2004 and 2011, enhanced by the launch of the protease inhibitors (PIs) boceprevir (BCV) and telaprevir (TVR) in addition to ribavirin and pegylated interferon (pegIFN). Costs will continue to rise with new treatments including sofosbuvir, which now include interferon free regimens...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27498756/anion-redox-chemistry-in-the-cobalt-free-3d-transition-metal-oxide-intercalation-electrode-li-li0-2ni0-2mn0-6-o2
#12
Kun Luo, Matthew R Roberts, Niccoló Guerrini, Nuria Tapia-Ruiz, Rong Hao, Felix Massel, David M Pickup, Silvia Ramos, Yi-Sheng Liu, Jinghua Guo, Alan V Chadwick, Laurent C Duda, Peter G Bruce
Conventional intercalation cathodes for lithium batteries store charge in redox reactions associated with the transition metal cations, e.g., Mn(3+/4+) in LiMn2O4, and this limits the energy storage of Li-ion batteries. Compounds such as Li[Li0.2Ni0.2Mn0.6]O2 exhibit a capacity to store charge in excess of the transition metal redox reactions. The additional capacity occurs at and above 4.5 V versus Li(+)/Li. The capacity at 4.5 V is dominated by oxidation of the O(2-) anions accounting for ∼0.43 e(-)/formula unit, with an additional 0...
September 7, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27429642/antimicrobials-a-global-alliance-for-optimizing-their-rational-use-in-intra-abdominal-infections-agora
#13
REVIEW
Massimo Sartelli, Dieter G Weber, Etienne Ruppé, Matteo Bassetti, Brian J Wright, Luca Ansaloni, Fausto Catena, Federico Coccolini, Fikri M Abu-Zidan, Raul Coimbra, Ernest E Moore, Frederick A Moore, Ronald V Maier, Jan J De Waele, Andrew W Kirkpatrick, Ewen A Griffiths, Christian Eckmann, Adrian J Brink, John E Mazuski, Addison K May, Rob G Sawyer, Dominik Mertz, Philippe Montravers, Anand Kumar, Jason A Roberts, Jean-Louis Vincent, Richard R Watkins, Warren Lowman, Brad Spellberg, Iain J Abbott, Abdulrashid Kayode Adesunkanmi, Sara Al-Dahir, Majdi N Al-Hasan, Ferdinando Agresta, Asma A Althani, Shamshul Ansari, Rashid Ansumana, Goran Augustin, Miklosh Bala, Zsolt J Balogh, Oussama Baraket, Aneel Bhangu, Marcelo A Beltrán, Michael Bernhard, Walter L Biffl, Marja A Boermeester, Stephen M Brecher, Jill R Cherry-Bukowiec, Otmar R Buyne, Miguel A Cainzos, Kelly A Cairns, Adrian Camacho-Ortiz, Sujith J Chandy, Asri Che Jusoh, Alain Chichom-Mefire, Caroline Colijn, Francesco Corcione, Yunfeng Cui, Daniel Curcio, Samir Delibegovic, Zaza Demetrashvili, Belinda De Simone, Sameer Dhingra, José J Diaz, Isidoro Di Carlo, Angel Dillip, Salomone Di Saverio, Michael P Doyle, Gereltuya Dorj, Agron Dogjani, Hervé Dupont, Soumitra R Eachempati, Mushira Abdulaziz Enani, Valery N Egiev, Mutasim M Elmangory, Paula Ferrada, Joseph R Fitchett, Gustavo P Fraga, Nathalie Guessennd, Helen Giamarellou, Wagih Ghnnam, George Gkiokas, Staphanie R Goldberg, Carlos Augusto Gomes, Harumi Gomi, Manuel Guzmán-Blanco, Mainul Haque, Sonja Hansen, Andreas Hecker, Wolfgang R Heizmann, Torsten Herzog, Adrien Montcho Hodonou, Suk-Kyung Hong, Reinhold Kafka-Ritsch, Lewis J Kaplan, Garima Kapoor, Aleksandar Karamarkovic, Martin G Kees, Jakub Kenig, Ronald Kiguba, Peter K Kim, Yoram Kluger, Vladimir Khokha, Kaoru Koike, Kenneth Y Y Kok, Victory Kong, Matthew C Knox, Kenji Inaba, Arda Isik, Katia Iskandar, Rao R Ivatury, Maurizio Labbate, Francesco M Labricciosa, Pierre-François Laterre, Rifat Latifi, Jae Gil Lee, Young Ran Lee, Marc Leone, Ari Leppaniemi, Yousheng Li, Stephen Y Liang, Tonny Loho, Marc Maegele, Sydney Malama, Hany E Marei, Ignacio Martin-Loeches, Sanjay Marwah, Amos Massele, Michael McFarlane, Renato Bessa Melo, Ionut Negoi, David P Nicolau, Carl Erik Nord, Richard Ofori-Asenso, AbdelKarim H Omari, Carlos A Ordonez, Mouaqit Ouadii, Gerson Alves Pereira Júnior, Diego Piazza, Guntars Pupelis, Timothy Miles Rawson, Miran Rems, Sandro Rizoli, Claudio Rocha, Boris Sakakhushev, Miguel Sanchez-Garcia, Norio Sato, Helmut A Segovia Lohse, Gabriele Sganga, Boonying Siribumrungwong, Vishal G Shelat, Kjetil Soreide, Rodolfo Soto, Peep Talving, Jonathan V Tilsed, Jean-Francois Timsit, Gabriel Trueba, Ngo Tat Trung, Jan Ulrych, Harry van Goor, Andras Vereczkei, Ravinder S Vohra, Imtiaz Wani, Waldemar Uhl, Yonghong Xiao, Kuo-Ching Yuan, Sanoop K Zachariah, Jean-Ralph Zahar, Tanya L Zakrison, Antonio Corcione, Rita M Melotti, Claudio Viscoli, Perluigi Viale
Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients. The cornerstones in the management of complicated IAIs are timely effective source control with appropriate antimicrobial therapy. Empiric antimicrobial therapy is important in the management of intra-abdominal infections and must be broad enough to cover all likely organisms because inappropriate initial antimicrobial therapy is associated with poor patient outcomes and the development of bacterial resistance...
2016: World Journal of Emergency Surgery: WJES
https://www.readbyqxmd.com/read/27385691/bone-morphogenetic-proteins-in-lumbar-arthrodesis-what-is-all-the-debate-about-commentary-on-an-article-by-daniel-c-beachler-phd-mhs-et-al-bone-morphogenetic-protein-use-and-cancer-risk-among-patients-undergoing-lumbar-arthrodesis-a-case-cohort-study-using
#14
Kern Singh, Dustin H Massel, Benjamin C Mayo, Daniel D Bohl, William W Long, Krishna D Modi
No abstract text is available yet for this article.
July 6, 2016: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/27359358/the-effect-of-surgeon-volume-on-complications-length-of-stay-and-costs-following-anterior-cervical-fusion
#15
Bryce A Basques, Philip K Louie, Grant D Shifflett, Michael P Fice, Benjamin C Mayo, Dustin H Massel, Javier Z Guzman, Daniel D Bohl, Kern Singh
STUDY DESIGN: Retrospective cohort. OBJECTIVE: To identify the association between surgeon volume and inpatient complications, length of stay, and costs associated with ACF. SUMMARY OF BACKGROUND DATA: Increased surgeon volume may be associated with improved outcomes following surgical procedures. However, there is a lack of information on the effect of surgeon volume on short-term outcomes following anterior cervical fusion (ACF). METHODS: A retrospective cohort study of ACF patients was performed using the Nationwide Inpatient Sample (NIS) from 2003-2009...
June 29, 2016: Spine
https://www.readbyqxmd.com/read/27294504/tunable-phonon-cavity-coupling-in-graphene-membranes
#16
R De Alba, F Massel, I R Storch, T S Abhilash, A Hui, P L McEuen, H G Craighead, J M Parpia
A major achievement of the past decade has been the realization of macroscopic quantum systems by exploiting the interactions between optical cavities and mechanical resonators. In these systems, phonons are coherently annihilated or created in exchange for photons. Similar phenomena have recently been observed through phonon-cavity coupling-energy exchange between the modes of a single system mediated by intrinsic material nonlinearity. This has so far been demonstrated primarily for bulk crystalline, high-quality-factor (Q > 10(5)) mechanical systems operated at cryogenic temperatures...
September 2016: Nature Nanotechnology
https://www.readbyqxmd.com/read/27254654/differences-in-short-term-outcomes-between-primary-and-revision-anterior-cervical-discectomy-and-fusion
#17
Bryce A Basques, Nathaniel T Ondeck, Erik J Geiger, Andre M Samuel, Adam M Lukasiewicz, Matthew L Webb, Daniel D Bohl, Dustin H Massel, Benjamin C Mayo, Kern Singh, Jonathan N Grauer
STUDY DESIGN: Retrospective cohort study. OBJECTIVE: To compare short-term morbidity for primary and revision anterior cervical discectomy and fusion (ACDF). SUMMARY OF BACKGROUND DATA: Revision ACDF procedures are relatively common, yet their risks are poorly characterized in the literature. There is a need to assess the relative risk of revision ACDF procedures compared to primary surgery. METHODS: The prospectively collected American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database was used to identify patients that underwent primary and revision ACDF from 2005 to 2014...
May 31, 2016: Spine
https://www.readbyqxmd.com/read/27128255/does-greater-body-mass-index-increase-the-risk-for-revision-procedures-following-a-single-level-minimally-invasive-lumbar-discectomy
#18
Daniel D Bohl, Junyoung Ahn, Benjamin C Mayo, Dustin H Massel, Ehsan Tabaraee, Robert A Sershon, Bryce A Basques, Kern Singh
STUDY DESIGN: Retrospective analysis of a prospectively maintained surgical registry. OBJECTIVE: To examine the association between body mass index (BMI) and the risk for undergoing a revision procedure following a single-level minimally invasive (MIS) lumbar discectomy (LD). SUMMARY OF BACKGROUND DATA: Studies conflict as to whether greater BMI contributes to recurrent herniation and the need for revision procedures following LD. Patients and surgeons would benefit from knowing whether greater BMI is a risk factor to guide the decision whether to pursue an operative versus non-operative treatment...
May 2016: Spine
https://www.readbyqxmd.com/read/27035584/malnutrition-predicts-infectious-and-wound-complications-following-posterior-lumbar-spinal-fusion
#19
Daniel D Bohl, Mary R Shen, Benjamin C Mayo, Dustin H Massel, William W Long, Krishna D Modi, Bryce A Basques, Kern Singh
STUDY DESIGN: Retrospective review of data collected prospectively by the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP). OBJECTIVE: To investigate the association between preoperative hypoalbuminemia, a marker for malnutrition, and complications during the thirty days following posterior lumbar fusion surgery. SUMMARY OF BACKGROUND DATA: Malnutrition is a potentially modifiable risk factor that may contribute to complications following spinal surgery...
March 30, 2016: Spine
https://www.readbyqxmd.com/read/27035581/anterior-cervical-discectomy-and-fusion-the-surgical-learning-curve
#20
Benjamin C Mayo, Dustin H Massel, Daniel D Bohl, William W Long, Krishna D Modi, Kern Singh
STUDY DESIGN: Case-series OBJECTIVE.: To investigate changes in intraoperative and postoperative parameters associated with the surgical learning curve for anterior cervical discectomy and fusion (ACDF). SUMMARY OF BACKGROUND DATA: ACDF is a common surgical spine procedure. The surgical learning curve for this procedure has not been previously characterized. METHODS: A prospectively maintained surgical database of consecutive patients who underwent primary 1-2 level ACDF for degenerative spine disease from 2006-2014 was reviewed...
March 30, 2016: Spine
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