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https://www.readbyqxmd.com/read/29326826/collision-tumor-consisting-of-a-colorectal-adenocarcinoma-and-dissemination-of-a-gastric-adenocarcinoma
#1
Ryoichi Miyamoto, Kazunori Kikuchi, Atsushi Uchida, Masayoshi Ozawa, Akira Kemmochi, Naoki Sano, Sosuke Tadano, Satoshi Inagawa, Shinya Adachi, Masayoshi Yamamoto
Background: Collision tumors, composed of histologically distinct tumor types, are rare entities, especially in the colorectum, and corresponding evidence-based clinical management or treatment strategies are poorly defined. This is the first report of a collision tumor composed of two histologically distinct adenocarcinomas. Case presentation: A 78-year-old male showed severe anemia and a 10% body weight loss over 1 month. Preoperative examination revealed T3N1M0 stage IIIA gastric cancer and T3N0M0 stage IIA rectal cancer...
2018: SAGE Open Medical Case Reports
https://www.readbyqxmd.com/read/29323615/short-term-and-long-term-outcomes-of-laparoscopic-versus-open-surgery-for-low-rectal-cancer
#2
Qing-Bin Wu, Xiang-Bing Deng, Xu-Bing Zhang, Ling-Hong Kong, Zong-Guang Zhou, Zi-Qiang Wang
AIM: To compare the short-term and long-term outcomes of laparoscopic versus open surgery for low rectal cancer. METHODS: Patients with low rectal cancer who underwent laparoscopic or open surgery at our department from January 2009 to December 2013 were enrolled in this retrospective study. The primary end points were 3-year local recurrence and overall and disease-free survival (DFS) rates. Secondary end points were intraoperative and postoperative outcomes. RESULTS: Laparoscopic group had longer operative time (165...
January 11, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29310394/a-meta-analysis-of-short-term-outcome-of-laparoscopic-surgery-versus-conventional-open-surgery-on-colorectal-carcinoma
#3
Guojun Tong, Guiyang Zhang, Jian Liu, Zhengzhao Zheng, Yan Chen, Enhai Cui
OBJECTIVE: The aim of this article is to study the superiority and safety of laparoscopic surgery for colorectal carcinoma. SUMMARY BACKGROUND DATA: Laparoscopy in rectal cancer is still not recommended as the treatment of choice by National Comprehensive Cancer Network guidelines. Laparoscopic rectal surgery is more complex and technically demanding, especially for mid and low rectal cancer. METHODS: A computer-based online research of retrospective or prospective studies addressing laparoscopic surgery versus conventional open surgery for colorectal carcinoma published in the last 11 years was performed in electronic database (Wangfang Database, China National Knowledge Infrastructure, Chinese Medical Current Contents, Pubmed, Medline, Ovid, Elsevier, ISI Web of Knowledge, Cohrane Database of Systematic Reviews)...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29290917/tumor-stroma-ratio-as-prognostic-factor-for-survival-in-rectal-adenocarcinoma-a-retrospective-cohort-study
#4
René Scheer, Alexi Baidoshvili, Shorena Zoidze, Marloes A G Elferink, Annefleur E M Berkel, Joost M Klaase, Paul J van Diest
AIM: To evaluate the prognostic value of the tumor-stroma ratio (TSR) in rectal cancer. METHODS: TSR was determined on hematoxylin and eosin stained histological sections of 154 patients treated for rectal adenocarcinoma without prior neoadjuvant treatment in the period 1996-2006 by two observers to assess reproducibility. Patients were categorized into three categories: TSR-high [carcinoma percentage (CP) ≥ 70%], TSR-intermediate (CP 40%, 50% and 60%) and TSR-low (CP ≤ 30%)...
December 15, 2017: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29282141/laparoscopic-intersphincteric-resection-versus-an-open-approach-for-low-rectal-cancer-a-meta-analysis
#5
REVIEW
Hanyu Chen, Bin Ma, Peng Gao, Hongchi Wang, Yongxi Song, Linhao Tong, Peiwen Li, Zhenning Wang
AIM: The aim of this study was to compare the short-term and mid-term effects of laparoscopic intersphincteric resection with the conventional open approach for patients with low rectal cancer through a meta-analysis. METHODS: The PubMed, EMBASE, Cochrane, and Ovid databases were searched for eligible studies until March 2017. Operation time, blood loss, circumferential resection margin-positive rate, distal margin length, number of resected lymph nodes, diverting stoma rate, postoperative overall morbidity, anastomotic leakage, and hospital stay were the main short-term effect endpoints...
December 28, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29277386/outcomes-of-persistent-lymph-node-involvement-after-neoadjuvant-therapy-for-stage-iii-rectal-cancer
#6
Anne M Dinaux, Lieve Leijssen, Liliana G Bordeianou, Hiroko Kunitake, Ramzi Amri, David L Berger
INTRODUCTION: Lymph node involvement is a well-known predictor of recurrent rectal cancer in patient who did not undergo neoadjuvant therapy patients. The role of persistent lymph node disease after neoadjuvant treatment, however, is debatable. This study compares outcomes of patients with clinical, stage III rectal cancer who had nodal disease on surgical pathology after neoadjuvant treatment to patients with negative nodes. METHODS: We reviewed retrospectively a consecutive cohort of all clinical, American Joint Committee on Cancer stage III rectal cancer patients who received neoadjuvant chemoradiotherapy and had an R0 resection at the Massachusetts General Hospital between 2004 and 2015...
December 22, 2017: Surgery
https://www.readbyqxmd.com/read/29275667/trends-in-presentation-treatment-and-survival-of-1777-patients-with-colorectal-cancer-over-a-decade-a-biobank-study
#7
Eetu Heervä, Anu Carpelan, Samu Kurki, Jari Sundström, Heikki Huhtinen, Arto Rantala, Annika Ålgars, Raija Ristamäki, Olli Carpén, Heikki Minn
BACKGROUND: Most survival data in colorectal cancer (CRC) is derived from clinical trials or register-based studies. Hospital Biobanks, linked with hospital electronic records, could serve as a data-gathering method based on consecutively collected tumor samples. The aim of this Biobank study was to analyze survival of colorectal patients diagnosed and treated in a single-center university hospital over a period of 12 years, and to evaluate factors contributing to outcome. MATERIAL AND METHODS: A total of 1777 patients with CRC treated during 2001-2012 were identified from the Auria Biobank, Turku, Finland...
December 23, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/29259791/diagnostic-accuracy-of-high-resolution-mri-as-a-method-to-predict-potentially-safe-endoscopic-and-surgical-planes-in-patients-with-early-rectal-cancer
#8
Svetlana Balyasnikova, James Read, Andrew Wotherspoon, S Rasheed, Paris Tekkis, Diana Tait, David Cunningham, G Brown
Introduction: Early rectal cancer (ERC) assessment should include prediction of the potential excision plane to safely remove lesions with clear deep margins and feasibility of organ preservation. Method: MRI accuracy for differentiating ≤T1sm2 (partially preserved submucosa) or ≤T2 (partially preserved muscularis) versus >T2 tumours was compared with the gold standard of pT stage T1sm1/2 versus ≤pT2 versus >pT2. N stage was also compared. The MRI protocol employed a standard surface phased array coil with a high resolution (0...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29250176/leucine-rich-repeat-containing-g-protein-coupled-receptor-5-and-cd133-expression-is-associated-with-tumor-progression-and-resistance-to-preoperative-chemoradiotherapy-in-low-rectal-cancer
#9
Yuzo Harada, Shinsuke Kazama, Teppei Morikawa, Koji Murono, Koji Yasuda, Kensuke Otani, Takeshi Nishikawa, Toshiaki Tanaka, Tomomichi Kiyomatsu, Kazushige Kawai, Keisuke Hata, Hiroaki Nozawa, Hironori Yamaguchi, Soichiro Ishihara, Toshiaki Watanabe
Preoperative chemoradiotherapy has been performed as a standard therapy for advanced low rectal cancer. Cancer stem cells (CSCs) have been reported to contribute to resistance to treatment and patient prognosis. Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5) and cluster of differentiation (CD133) are putative markers for CSCs. However, their prognostic ability remains unknown, and evaluation of a single marker can be insufficient due to the heterogeneity of cancer. LGR5 and CD133 expression was immunohistochemically evaluated in surgical specimens of 56 patients who received curative resection following chemoradiotherapy for advanced low rectal cancer...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29246016/optimal-treatment-strategies-for-clinically-suspicious-lateral-pelvic-lymph-node-metastasis-in-rectal-cancer
#10
Hye Jin Kim, Gyu-Seog Choi, Jun Seok Park, Soo Yeun Park, Seung Hyun Cho, Soo Jung Lee, Byung Woog Kang, Jong Gwang Kim
Background: Although lateral pelvic lymph node (LPN) metastasis is a major cause of local recurrence in patients with rectal cancer, controversy still remains on the treatment of suspected LPN metastasis, "suspicious LPN". We aimed to determine the optimal treatment strategies for suspicious LPN, in patients with locally advanced rectal cancer who underwent preoperative chemoradiotherapy (CRT). Materials and Methods: Of 377 patients who received preoperative CRT for rectal cancer between 2006 and 2013, 84 (22...
November 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/29245914/radiotherapy-for-stage-iia-rectal-cancer-may-not-benefit-all
#11
Xiang Hu, Ya-Qi Li, Qing-Guo Li, Yan-Lei Ma, Jun-Jie Peng, San-Jun Cai
This study sought to determine whether additional radiotherapy is necessary in patients after optimal surgery for stage IIA rectal cancer and how the different covariates influence the efficacy of radiotherapy. The first primary rectal cancer was identified from the 1988-December 2013 Surveillance, Epidemiology and End Results database. We identified 13647 patients with IIA rectal cancer, in which 39.6% received neo-adjuvant radiotherapy and in another 14.96% patients the adjuvant radiotherapy were performed...
November 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/29242035/outcomes-of-liver-first-strategy-and-classical-strategy-for-synchronous-colorectal-liver-metastases-in-sweden
#12
Valentinus T Valdimarsson, Ingvar Syk, Gert Lindell, Agneta Norén, Bengt Isaksson, Per Sandström, Magnus Rizell, Bjarne Ardnor, Christian Sturesson
BACKGROUND: Patients with synchronous colorectal liver metastases (sCRLM) are increasingly operated with liver resection before resection of the primary cancer. The aim of this study was to compare outcomes in patients following the liver-first strategy and the classical strategy (resection of the bowel first) using prospectively registered data from two nationwide registries. METHODS: Clinical, pathological and survival outcomes were compared between the liver-first strategy and the classical strategy (2008-2015)...
December 11, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29232537/laparoscopic-versus-conventional-open-surgery-in-intersphincteric-resection-for-low-rectal-cancer-a-systematic-review-and-meta-analysis
#13
Xubing Zhang, Qingbin Wu, Tao Hu, Chaoyang Gu, Liang Bi, Ziqiang Wang
AIM: This meta-analysis aims at comparing laparoscopic intersphincteric resection (LISR) with conventional open ISR (OISR) for low rectal cancer (LRC) in terms of intraoperative, postoperative, pathological, and survival outcomes. MATERIALS AND METHODS: A systematic literature search with no limits was performed in PubMed and Ovid. The last search was performed on May 27, 2017. The outcomes of interests included intraoperative outcomes: operative time and blood loss; postoperative outcomes: hospital day, postoperative hospital day, time to first flatus, time to normal diet, ileus, intra-abdominal abscess, anastomotic leakage, anastomotic stricture, wound infection, pneumonia, urinary complication, morbidity, and mortality; pathological outcomes: lymph node harvested, R0 resection rate, distance of proximal resection margin, distal resection margin and circumferential resection margin (CRM), and positive CRM; survival outcomes: 3-year overall survival (OS), 3-year disease-free survival (DFS), 5-year OS, and 5-year DFS...
December 12, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29229327/dose-escalation-using-contact-x-ray-brachytherapy-after-external-beam-radiotherapy-as-nonsurgical-treatment-option-for-rectal-cancer-outcomes-from-a-single-center-experience
#14
Arthur Sun Myint, Fraser McLean Smith, Simon Gollins, Helen Wong, Christopher Rao, Karen Whitmarsh, Raj Sripadam, Paul Rooney, Michael Hershman, D Mark Pritchard
PURPOSE: To review the outcomes of rectal cancer patients treated with a nonsurgical approach using contact x-ray brachytherapy (CXB) when suspicious residual disease (≤3 cm) was present after external beam chemoradiation therapy/radiation therapy (EBCRT/EBRT). METHODS AND MATERIALS: Outcome data for rectal cancer patients referred to our institution from 2003 to 2012 were retrieved from an institutional database. These patients were referred after initial local multidisciplinary team discussion because they were not suitable for, or had refused, surgery...
October 20, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29229310/tumor-volume-predicts-local-recurrence-in-early-rectal-cancer-treated-with-radical-resection-a-retrospective-observational-study-of-270-patients
#15
Yanhui Jiang, Kaiyun You, Xingsheng Qiu, Zhuofei Bi, Huaqian Mo, Liting Li, Yimin Liu
OBJECTIVE: Radical resection is regarded as the primary treatment for early rectal cancer, and tumor volume is an independent predictor of many other types of cancer. The purpose of the present study is to assess the effect of tumor volume on the survival of patients with early rectal cancer treated with radical surgery. METHODS: A total of 270 patients with histologically confirmed stage T1/2 N0 rectal cancer who underwent radical resection between September 2006 and September 2014 were enrolled in this study...
December 8, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/29203979/young-vs-old-colorectal-cancer-in-indian-subcontinent-a-tertiary-care-center-experience
#16
Ashish B Pokharkar, Manish Bhandare, Prachi Patil, Shaesta Mehta, Reena Engineer, Avanish P Saklani
This study aims to compare patient, tumor, treatment-related factors and survival between young (<45 years) and old (>45 years) Indian colorectal cancer (CRC) patients. Total 778 patients of CRC were registered at tertiary cancer center in India between 1 August 2013 and 31 July 2014. Patients were followed up for median period of 27.73 months. Data regarding patient, tumor, treatment and survival-related factors were collected. Patients were divided in young (≤45 years) and old (>45 years) age groups...
December 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29203976/laparoscopic-versus-open-approach-for-intersphincteric-resection-results-from-a-tertiary-cancer-center-in-india
#17
Vishwas D Pai, Pavan Sugoor, Prachi S Patil, Vikas Ostwal, Reena Engineer, Supreeta Arya, Ashwin Desouza, Avanish P Saklani
The study aims to compare open intersphincteric resection (OISR) with laparoscopic intersphincteric resection (LISR) in terms of short-term oncological and clinical outcomes. This is a retrospective review of a prospectively maintained database including all the patients of rectal cancer who underwent intersphincteric resection (ISR) at Tata Memorial Centre between 1st July 2013 and 30th November 2015. Short-term oncological parameters evaluated included circumferential resection margin involvement (CRM), distal resection margin involvement, and number of nodes harvested...
December 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29203973/long-term-functional-and-oncological-outcomes-following-intersphincteric-resection-for-low-rectal-cancers
#18
Sivakumar Mahalingam, Ramakrishnan Ayloor Seshadri, Surendran Veeraiah
Surgery for low rectal cancer often involves a permanent stoma. Intersphincteric resection (ISR) with colo-anal anastomosis is a valuable sphincter sparing surgical procedure that avoids the need for permanent stoma in patients with low rectal cancer. The aim of this study was to analyze the long-term functional and oncological outcomes following ISR. This was a retrospective analysis of patients with low rectal cancer who underwent ISR with colo-anal anastomosis in our institution between 2007 and 2015. All patients had a diversion stoma...
December 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29198494/distribution-of-metastases-in-mesorectum-is-unpredictable-metastases-do-not-respect-tumor-localization-even-in-small-non-circumferential-rectal-cancers
#19
Magdaléna Linter Kapišinská, Eva Hovorková, Veronika Závalová, Zdeněk Šubrt, Martin Kuneš, Alexander Ferko
INTRODUCTION: Low anterior resection with total mesorectal excision (TME) is the gold standard for surgical treatment of rectal carcinoma. The radicality of this procedure is negatively counterbalanced by morbidity, lethality, and numerous other complications. Local excision would appear to be an attractive alternative, but its radicality is disputable due to risk of undetected metastasis to the mesorectum. The study aimed to determine the location of mesorectal metastases with respect to circumferentially - located tumors in patients with tumors involving less than one-third of the rectal circumference...
January 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29198168/simultaneous-laparoscopic-proctocolectomy-tatme-and-robot-assisted-radical-prostatectomy-for-synchronous-rectal-and-prostate-cancer
#20
Ben Gys, Karen Fransis, Guy Hubens, Sylvie Van den Broeck, Bart Op de Beeck, Niels Komen
OBJECTIVE: We would like to present a patient with a history of ulcerative colitis suffering from a synchronous rectal and prostate cancer treated with a laparoscopic total proctocolectomy (with TaTME) and Retzius sparing RARP simultaneously. METHODS: Retzius sparing RARP with bilateral lymph node harvesting was performed first. Afterwards, TaTME was commenced with the placement of a Lonestar® retractor and GelPort®. Anterior dissection was troubled unexpectedly by outspoken fibrosis...
December 4, 2017: Acta Chirurgica Belgica
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