keyword
MENU ▼
Read by QxMD icon Read
search

Human computer interaction

keyword
https://www.readbyqxmd.com/read/28926957/combining-a-multi-agent-system-and-communication-middleware-for-smart-home-control-a-universal-control-platform-architecture
#1
Song Zheng, Qi Zhang, Rong Zheng, Bi-Qin Huang, Yi-Lin Song, Xin-Chu Chen
In recent years, the smart home field has gained wide attention for its broad application prospects. However, families using smart home systems must usually adopt various heterogeneous smart devices, including sensors and devices, which makes it more difficult to manage and control their home system. How to design a unified control platform to deal with the collaborative control problem of heterogeneous smart devices is one of the greatest challenges in the current smart home field. The main contribution of this paper is to propose a universal smart home control platform architecture (IAPhome) based on a multi-agent system and communication middleware, which shows significant adaptability and advantages in many aspects, including heterogeneous devices connectivity, collaborative control, human-computer interaction and user self-management...
September 16, 2017: Sensors
https://www.readbyqxmd.com/read/28926141/working-at-the-membrane-interface-ligand-induced-changes-in-dynamic-conformation-and-oligomeric-structure-in-human-aromatase
#2
Giovanna Di Nardo, Giuseppe Cimicata, Roberta Baravalle, Valentina Dell'Angelo, Alberto Ciaramella, Gianluca Catucci, Piero Ugliengo, Gianfranco Gilardi
Aromatase catalyses the biosynthesis of estrogens from androgens. Due to the physiological importance of this conversion of lipophilic substrates, the interaction with the lipid bilayer for this cytochrome P450 is crucial for its dynamics that must allow an easy access to substrates and inhibitors. Here, aromatase-anastrozole interaction is studied combining computational methods to identify possible access/egress routes with the protein inserted in the membrane and experimental tools aimed at the investigation of the effect of the inhibitor on the protein conformation...
September 19, 2017: Biotechnology and Applied Biochemistry
https://www.readbyqxmd.com/read/28921575/ingested-nitrate-and-nitrite-disinfection-by-products-and-pancreatic-cancer-risk-in-postmenopausal-women
#3
Arbor J L Quist, Maki Inoue-Choi, Peter J Weyer, Kristin E Anderson, Kenneth P Cantor, Stuart Krasner, Laura E Beane Freeman, Mary H Ward, Rena R Jones
Nitrate and nitrite are precursors of N-nitroso compounds (NOC), probable human carcinogens that cause pancreatic tumors in animals. Disinfection by-products (DBP) exposures have also been linked with digestive system cancers, but few studies have evaluated relationships with pancreatic cancer. We investigated the association of pancreatic cancer with these drinking water contaminants and dietary nitrate/nitrite in a cohort of postmenopausal women in Iowa (1986-2011). We used historical monitoring and treatment data to estimate levels of long-term average nitrate and total trihalomethanes (TTHM; the sum of the most prevalent DBP class) and the duration exceeding one-half the maximum contaminant level (>½ MCL; nitrate-nitrogen 5mg/L, 40µg/L TTHM) among participants on public water supplies (PWS) >10 years...
September 16, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28919164/integrated-analysis-of-microrna-and-gene-expression-profiles-reveals-a-functional-regulatory-module-associated-with-liver-fibrosis
#4
Wei Chen, Wenshan Zhao, Aiting Yang, Anjian Xu, Huan Wang, Min Cong, Tianhui Liu, Ping Wang, Hong You
BACKGROUND: Liver fibrosis, characterized with the excessive accumulation of extracellular matrix (ECM) proteins, represents the final common pathway of chronic liver inflammation. Ever-increasing evidence indicates microRNAs (miRNAs) dysregulation have important implications in the different stages of liver fibrosis. However, our knowledge of miRNA-gene regulation details pertaining to such disease remains unclear. METHODS: The publicly available Gene Expression Omnibus (GEO) datasets of patients suffered from cirrhosis were extracted for integrated analysis...
September 14, 2017: Gene
https://www.readbyqxmd.com/read/28917135/failing-to-learn-from-negative-prediction-errors-obesity-is-associated-with-alterations-in-a-fundamental-neural-learning-mechanism
#5
David Mathar, Jane Neumann, Arno Villringer, Annette Horstmann
Prediction errors (PEs) encode the difference between expected and actual action outcomes in the brain via dopaminergic modulation. Integration of these learning signals ensures efficient behavioral adaptation. Obesity has recently been linked to altered dopaminergic fronto-striatal circuits, thus implying impairments in cognitive domains that rely on its integrity. 28 obese and 30 lean human participants performed an implicit stimulus-response learning paradigm inside an fMRI scanner. Computational modeling and psycho-physiological interaction (PPI) analysis was utilized for assessing PE-related learning and associated functional connectivity...
August 24, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28915468/spectral-and-computational-features-of-the-binding-between-riparins-and-human-serum-albumin
#6
Cintia Ramos Camargo, Ícaro Putinhon Caruso, Stanley Juan Chavez Gutierrez, Marcelo Andres Fossey, José Maria Barbosa Filho, Marinônio Lopes Cornélio
The green Brazilian bay leaf, a spice much prized in local cuisine (Aniba riparia, Lauraceae), contains chemical compounds presenting benzoyl-derivatives named riparins, which have anti-inflammatory, antimicrobial and anxiolytic properties. However, it is unclear what kind of interaction riparins perform with any molecular target. As a profitable target, human serum albumin (HSA) is one of the principal extracellular proteins, with an exceptional capacity to interact with several molecules, and it also plays a crucial role in the transport, distribution, and metabolism of a wide variety of endogenous and exogenous ligands...
September 8, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28913763/a-patient-specific-three-dimensional-hemodynamic-model-of-the-circle-of-willis
#7
Hamed Rezaie, Ali Ashrafizadeh, Afsaneh Mojra
Circle of Willis (CoW) is one of the most important cerebral arteries in the human body and various attempts have been made to study the hemodynamic of blood flow in this vital part of the brain. In the present study, blood flow in a patient specific CoW is numerically modeled to predict disease-prone regions of the CoW. Medical images and computer aided design software are used to construct a realistic three-dimensional model of the CoW for this particular case. The arteries are considered as elastic conduits and the interactions between arterial walls and the blood flow are taken into account...
September 14, 2017: Cardiovascular Engineering and Technology
https://www.readbyqxmd.com/read/28911111/combinatorial-ensemble-mirna-target-prediction-of-co-regulation-networks-with-non-prediction-data
#8
Jason A Davis, Sita J Saunders, Martin Mann, Rolf Backofen
MicroRNAs (miRNAs) are key regulators of cell-fate decisions in development and disease with a vast array of target interactions that can be investigated using computational approaches. For this study, we developed metaMIR, a combinatorial approach to identify miRNAs that co-regulate identified subsets of genes from a user-supplied list. We based metaMIR predictions on an improved dataset of human miRNA-target interactions, compiled using a machine-learning-based meta-analysis of established algorithms. Simultaneously, the inverse dataset of negative interactions not likely to occur was extracted to increase classifier performance, as measured using an expansive set of experimentally validated interactions from a variety of sources...
September 6, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28906061/opposite-effect-of-polymorphic-mutations-on-the-electrostatic-aggregation-of-human-alanine-glyoxylate-aminotransferase-implications-for-the-pathogenesis-of-primary-hyperoxaluria-type-i
#9
Mirco Dindo, Carolina Conter, Barbara Cellini
Protein aggregates formation is the basis of several misfolding diseases, including those displaying loss-of-function pathogenesis. Although aggregation is often attributed to the population of intermediates exposing hydrophobic surfaces, the contribution of electrostatic forces has recently gained attention. Here we combined computational and in vitro studies to investigate the aggregation process of human peroxisomal alanine:glyoxylate aminotransferase (AGT), a pyridoxal 5'-phosphate (PLP)-dependent enzyme involved in glyoxylate detoxification...
September 14, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28901615/model-based-dose-reconstruction-for-ct-dose-estimation
#10
Mingye Wu, Zhye Yin, Bruno De Man
PURPOSE: Our goal is to develop a model-based approach for CT dose estimation. We previously presented a CT dose estimation method that offered good accuracy in soft tissue regions but lower accuracy in bone regions. In this work, we propose an improved physic-based approach to achieve high accuracy for any materials and realistic clinical anatomies. METHODS: Like Monte Carlo techniques, we start from a model or image of the patient and we model all relevant x-ray interaction processes...
September 2017: Medical Physics
https://www.readbyqxmd.com/read/28900751/effect-of-wavelength-and-beam-width-on-penetration-in-light-tissue-interaction-using-computational-methods
#11
Caerwyn Ash, Michael Dubec, Kelvin Donne, Tim Bashford
Penetration depth of ultraviolet, visible light and infrared radiation in biological tissue has not previously been adequately measured. Risk assessment of typical intense pulsed light and laser intensities, spectral characteristics and the subsequent chemical, physiological and psychological effects of such outputs on vital organs as consequence of inappropriate output use are examined. This technical note focuses on wavelength, illumination geometry and skin tone and their effect on the energy density (fluence) distribution within tissue...
September 12, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28900225/the-neural-basis-of-spatial-vision-losses-in-the-dysfunctional-visual-system
#12
Jinfeng Huang, Yifeng Zhou, Caiyuan Liu, Zhongjian Liu, Chunmeng Luan, Tzvetomir Tzvetanov
Human vision relies on correct information processing from the eye to various visual areas. Disturbances in the visual perception of simple features are believed to come from low-level network (e.g., V1) disruptions. In the present study, we modelled monocular losses in spatial vision through plausible multiple network modifications in early visual coding. We investigated perceptual deficits in anisometropic amblyopia and used the monocular tilt illusion as a probe of primary visual cortex orientation coding and inhibitory interactions...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28898077/simulation-of-reversible-protein-protein-binding-and-calculation-of-binding-free-energies-using-perturbed-distance-restraints
#13
Jan Walther Perthold, Chris Oostenbrink
Virtually all biological processes depend on the interaction between proteins at some point. The correct prediction of biomolecular binding free-energies has many interesting applications in both basic and applied pharmaceutical research. While recent advances in the field of molecular dynamics (MD) simulations have proven the feasibility of the calculation of protein-protein binding free energies, the large conformational freedom of proteins and complex free energy landscapes of binding processes make such calculations a difficult task...
September 12, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28895532/a-synaptotagmin-suppressor-screen-indicates-snare-binding-controls-the-timing-and-ca-2-cooperativity-of-vesicle-fusion
#14
Zhuo Guan, Maria Bykhovskaia, Ramon A Jorquera, Roger Bryan Sutton, Yulia Akbergenova, J Troy Littleton
The synaptic vesicle Ca(2+) sensor Synaptotagmin binds Ca(2+) through its two C2 domains to trigger membrane interactions. Beyond membrane insertion by the C2 domains, other requirements for Synaptotagmin activity are still being elucidated. To identify key residues within Synaptotagmin required for vesicle cycling, we took advantage of observations that mutations in the C2B domain Ca(2+)-binding pocket dominantly disrupt release from invertebrates to humans. We performed an intragenic screen for suppressors of lethality induced by expression of Synaptotagmin C2B Ca(2+)-binding mutants in Drosophila...
September 12, 2017: ELife
https://www.readbyqxmd.com/read/28893671/combining-multivariate-statistics-and-the-think-aloud-protocol-to-assess-human-computer-interaction-barriers-in-symptom-checkers
#15
Luis Marco-Ruiz, Erlend Bønes, Estela de la Asunción, Elia Gabarrón, Juan Carlos Aviles-Solis, Eunji Lee, Vicente Traver, Keiichi Sato, Johan G Bellika
Symptom checkers are software tools that allow users to submit a set of symptoms and receive advice related to them in the form of a diagnosis list, health information or triage. The heterogeneity of their potential users and the number of different components in their user interfaces can make testing with end-users unaffordable. We designed and executed a two-phase method to test the respiratory diseases module of the symptom checker Erdusyk. Phase I consisted of an online test with a large sample of users (n = 53)...
September 9, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28893623/cyp17a1-inhibitor-abiraterone-an-anti-prostate-cancer-drug-also-inhibits-the-21-hydroxylase-activity-of-cyp21a2
#16
Jana Malikova, Simone Brixius-Anderko, Sameer S Udhane, Shaheena Parween, Bernhard Dick, Rita Bernhardt, Amit V Pandey
Abiraterone is an inhibitor of CYP17A1 which is used for the treatment of castration resistant prostate cancer. Abiraterone is known to inhibit several drug metabolizing cytochrome P450 enzymes including CYP1A2, CYP2D6, CYP2C8, CYP2C9, CYP2C19, CYP3A4 and CYP3A5, but its effects on steroid metabolizing P450 enzymes are not clear. In preliminary results, we had observed inhibition of CYP21A2 by 1μM abiraterone. Here we are reporting the effect of abiraterone on activities of CYP21A2 in human adrenal cells as well as with purified recombinant CYP21A2...
September 8, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28892478/continuous-robust-sound-event-classification-using-time-frequency-features-and-deep-learning
#17
Ian McLoughlin, Haomin Zhang, Zhipeng Xie, Yan Song, Wei Xiao, Huy Phan
The automatic detection and recognition of sound events by computers is a requirement for a number of emerging sensing and human computer interaction technologies. Recent advances in this field have been achieved by machine learning classifiers working in conjunction with time-frequency feature representations. This combination has achieved excellent accuracy for classification of discrete sounds. The ability to recognise sounds under real-world noisy conditions, called robust sound event classification, is an especially challenging task that has attracted recent research attention...
2017: PloS One
https://www.readbyqxmd.com/read/28891941/cox-inhibition-profile-and-molecular-docking-studies-of-some-2-trimethoxyphenyl-thiazoles
#18
Smaranda Dafina Oniga, Liliana Pacureanu, Cristina Ioana Stoica, Mariana Doina Palage, Alexandra Crăciun, Laurentiu Răzvan Rusu, Elena-Luminita Crisan, Cătălin Araniciu
Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used therapeutic agents that exhibit frequent and sometimes severe adverse effects, including gastrointestinal ulcerations and cardiovascular disorders. In an effort to obtain safer NSAIDs, we assessed the direct cyclooxygenase (COX) inhibition activity and we investigated the potential COX binding mode of some previously reported 2-(trimethoxyphenyl)-thiazoles. The in vitro COX inhibition assays were performed against ovine COX-1 and human recombinant COX-2...
September 9, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28888036/exploring-the-interaction-between-mycobacterium-tuberculosisenolase-and-human-plasminogen-using-computational-methods-and-experimental-techniques
#19
Amit Rahi, Alisha Dhiman, Damini Singh, Andrew M Lynn, Mohd Rehan, Rakesh Bhatnagar
Surface localized microbial enolases' binding with human plasminogen has been increasingly proven to have an important role in initial infection cycle of several human pathogens.Likewise, surface localized Mycobacterium tuberculosis (Mtb) enolase also binds to human plasminogen, and this interaction may entail crucial consequences for granuloma stability. The current study is the first attempt to explore the plasminogen interacting residues of enolase from Mtb. Beginning with the structural modeling of Mtbenolase, the binding pose of Mtbenolase and human plasminogen was predicted using protein-protein docking simulations...
September 9, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28887545/human-to-human-closed-loop-control-based-on-brain-to-brain-interface-and-muscle-to-muscle-interface
#20
M Ebrahim M Mashat, Guangye Li, Dingguo Zhang
Novel communication techniques have always been fascinating for humankind. This pilot study presents an approach to human interaction by combining direct brain-to-brain interface (BBI) and muscle-to-muscle interface (MMI) in a closed-loop pattern. In this system, artificial paths (data flows) functionally connect natural paths (nerves). The intention from one subject (sender) is recognized using electroencephalography (EEG) based brain-computer interface (BCI), which is sent out to trigger transcranial magnetic stimulation (TMS) on the other subject (receiver) and induce hand motion; meanwhile TMS results in a significant change on the motor evoked potentials (MEP) recorded by electromyography (EMG) of the receiver's arm, which triggers functional electrical stimulation (FES) applied to the sender's arm and generates hand motion...
September 8, 2017: Scientific Reports
keyword
keyword
30330
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"