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https://www.readbyqxmd.com/read/29780857/multi-omic-network-based-interrogation-of-rat-liver-metabolism-following-gastric-bypass-surgery-featuring-swath-proteomics
#1
Gautham Vivek Sridharan, Matthew D'Alessandro, Shyam Sundhar Bale, Vicky Bhagat, Hugo Gagnon, John M Asara, Korkut Uygun, Martin L Yarmush, Nima Saeidi
Morbidly obese patients often elect for Roux-en-Y gastric bypass (RYGB), a form of bariatric surgery that triggers a remarkable 30% reduction in excess body weight and reversal of insulin resistance for those who are type II diabetic. A more complete understanding of the underlying molecular mechanisms that drive the complex metabolic reprogramming post-RYGB could lead to innovative non-invasive therapeutics that mimic the beneficial effects of the surgery, namely weight loss, achievement of glycemic control, or reversal of non-alcoholic steatohepatitis (NASH)...
September 2017: Technology
https://www.readbyqxmd.com/read/29764908/management-of-endocrine-disease-which-metabolic-procedure-comparing-outcomes-in-sleeve-gastrectomy-and-roux-en-y-gastric-bypass
#2
Adrian T Billeter, Javier de la Garza Herrera, Katharina M Scheurlen, Felix Nickel, Franck Billmann, Beat Müller-Stich
Obesity and its associated comorbidities have become one of the largest challenges for health care in the near future. Conservative therapy for obesity and related comorbidities have a very high failure rate and poor long-term results. Similarly, the conservative and medical management of the majority of metabolic diseases such as type 2 diabetes mellitus are only able to slow down disease progression but have no causal effect on the disease process. Obesity surgery has evolved as a highly effect therapy for severe obesity achieving long-lasting weight loss...
May 15, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29725976/impact-of-weight-regain-on-the-evolution-of-non-alcoholic-fatty-liver-disease-after-roux-en-y-gastric-bypass-a-3-year-follow-up
#3
Laísa Simakawa Jimenez, Fábio Henrique Mendonça Chaim, Felipe David Mendonça Chaim, Murillo Pimentel Utrini, Martinho Antonio Gestic, Elinton Adami Chaim, Everton Cazzo
BACKGROUND: The influence of post-surgical weight regain on the course of non-alcoholic fatty liver disease (NAFLD) is unclear. OBJECTIVE: To evaluate the influence of weight regain on the NAFLD assessed by means of a non-invasive score after Roux-en-gastric bypass (RYGB) over a 3-year period. METHODS: This is a prospective observational cohort study which evaluated individuals who underwent RYGB. Comparisons were made between the periods immediately before surgery and 12, 24, and 36 months following surgery...
May 3, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29679615/novel-protective-role-of-kallistatin-in-obesity-by-limiting-adipose-tissue-low-grade-inflammation-and-oxidative-stress
#4
Gema Frühbeck, Javier Gómez-Ambrosi, Amaia Rodríguez, Beatriz Ramírez, Víctor Valentí, Rafael Moncada, Sara Becerril, Xabier Unamuno, Camilo Silva, Javier Salvador, Victoria Catalán
OBJECTIVE: Kallistatin plays an important role in the inhibition of inflammation, oxidative stress, fibrosis and angiogenesis. We aimed to determine the impact of kallistatin on obesity and its associated metabolic alterations as well as its role in adipocyte inflammation and oxidative stress. METHODS: Samples obtained from 95 subjects were used in a case-control study. Circulating concentrations and expression levels of kallistatin as well as key inflammation, oxidative stress and extracellular matrix remodelling-related genes were analyzed...
April 18, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29560647/hepatic-complications-of-bariatric-surgery-the-reverse-side-of-the-coin
#5
REVIEW
U Vespasiani-Gentilucci, F Vorini, S Carotti, A De Vincentis, G Galati, P Gallo, N Scopinaro, A Picardi
BACKGROUND: Even if the jejunoileal bypass has been definitely abandoned due to the high rate of hepatic complications, cases of liver injury after the new bariatric procedures are still reported. We aimed to review the available literature concerning liver damage associated with the older and newer types of bariatric surgeries. METHODS: An extensive literature search of MEDLINE was performed using different combinations of the following terms: "bariatric surgery OR biliopancreatic diversion OR jejunoileal bypass OR roux-en-y gastric bypass OR vertical banded gastroplasty OR laparoscopic adjustable gastric banding" AND "hepatic/liver damage OR hepatic/liver impairment OR hepatic/liver failure"...
October 2017: Acta Gastro-enterologica Belgica
https://www.readbyqxmd.com/read/29500677/alcohol-consumption-in-obese-patients-before-and-after-gastric-bypass-as-assessed-with-the-alcohol-marker-phosphatidylethanol-peth
#6
Lisa Walther, Carl-Magnus Brodén, Anders Isaksson, Jan L Hedenbro
INTRODUCTION: Roux-en-Y gastric bypass (RYGB) causes more rapid and enhanced absorption of alcohol. RYGB patients have also been reported to use more inpatient care for alcohol-related disease than do patients after other bariatric procedures. The present study was designed to evaluate alcohol consumption level before and after gastric bypass using a sensitive and specific alcohol biomarker. MATERIALS AND METHODS: Two separate consecutive groups of patients and a group of healthy blood donors, as reference group, were included in the study...
March 2, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29462566/non-alcoholic-fatty-liver-disease-and-gastric-bypass-surgery-regulate-serum-and-hepatic-levels-of-pyruvate-kinase-isoenzyme-m2
#7
Luca Meoli, Nitin K Gupta, Nima Saeidi, Courtney Panciotti, Sudha B Biddinger, Kathleen E Corey, Nicholas Stylopoulos
Treatment of non-alcoholic fatty liver disease (NAFLD) focuses on the underlying metabolic syndrome, and Roux-en-Y gastric bypass surgery (RYGB) remains one of the most effective options. In rodents and human patients, RYGB induces an increase in the gene and protein expression levels of the M2 isoenzyme of Pyruvate Kinase (PKM2) in the jejunum. Since PKM2 can be secreted in the circulation, our hypothesis was that the circulating levels of PKM2 increase after RYGB. Our data, however, revealed an unexpected finding and a potential new role of PKM2 for the natural history of metabolic syndrome and NAFLD...
February 20, 2018: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29305304/sleeve-gastrectomy-surgery-when-2-alcoholic-drinks-are-converted-to-4
#8
María Belén Acevedo, J Christopher Eagon, Bruce D Bartholow, Samuel Klein, Kathleen K Bucholz, Marta Yanina Pepino
BACKGROUND: While it is well established that Roux-en-Y gastric bypass (RYGB) causes a rapid and heightened peak blood alcohol concentration (BAC), results from previous studies on the effects of sleeve gastrectomy (SG) on alcohol pharmacokinetics are conflicting. Data from 2 studies found SG did not affect BAC, whereas another study found SG caused a heightened peak BAC after alcohol ingestion. Moreover, these 3 studies estimated BAC from breathalyzers, which might not reliably estimate peak BAC...
March 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29222767/platelet-counts-and-liver-enzymes-after-gastric-bypass-surgery
#9
Hans-Erik Johansson, Anna Wåhlén, Erica Aldenbäck, Arvo Haenni
BACKGROUND: Obesity is associated with chronic inflammation, liver steatosis and increased liver enzymes such as gamma-glutamyltransferase (GGT) and alanine aminotransferase (ALT), markers for non-alcoholic fatty liver disease (NAFLD) and liver fat content. Increased platelet counts (PCs) are a biomarker reflecting inflammation and the degree of fibrosis in NAFLD. We investigated alterations in PCs, GGT, ALT, C-reactive protein (CRP) and ferritin after Roux-en-Y gastric bypass (RYGBP)...
December 8, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29119336/bariatric-surgery-as-an-efficient-treatment-for-non-alcoholic-fatty-liver-disease-in-a-prospective-study-with-1-year-follow-up-bariscan-study
#10
Felix Nickel, Christian Tapking, Laura Benner, Janina Sollors, Adrian T Billeter, Hannes G Kenngott, Loay Bokhary, Mathias Schmid, Moritz von Frankenberg, Lars Fischer, Sebastian Mueller, Beat P Müller-Stich
BACKGROUND: Bariatric surgery gains attention as a potential treatment for non-alcoholic fatty liver disease (NAFLD). The present study aimed to evaluate improvement of NAFLD after the two most common bariatric procedures with validated non-invasive instruments. MATERIAL AND METHODS: N = 100 patients scheduled for laparoscopic sleeve gastrectomy (LSG) or Roux-en-Y gastric bypass (RYGB) were included. NAFLD was evaluated preoperatively and postoperatively with liver stiffness measurement by transient elastography and laboratory-based fibrosis scores...
November 9, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29110243/problematic-alcohol-use-and-associated-characteristics-following-bariatric-surgery
#11
Kathryn E Smith, Scott G Engel, Kristine J Steffen, Luis Garcia, Karen Grothe, Afton Koball, James E Mitchell
PURPOSE: Evidence suggests that a significant minority of individuals who undergo Roux-en-Y gastric bypass (RYGB) experience problematic alcohol and substance use following surgery. However, little research has examined characteristics, drinking patterns, and possible risk factors within this population. To provide descriptive information of a sample of adults with self-identified alcohol use problems following bariatric surgery, this study examined (1) alcohol and substance use symptoms using standardized assessments, (2) current and past psychiatric comorbidity, (3) subjective changes in alcohol sensitivity following surgery, and (4) specific patterns of alcohol use prior to and following bariatric surgery...
November 6, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29032488/how-do-individuals-develop-alcohol-use-disorder-after-bariatric-surgery-a-grounded-theory-exploration
#12
Ruth Yoder, Padraig MacNeela, Ronan Conway, Caroline Heary
BACKGROUND: Bariatric surgery is the most effective treatment for severe obesity. However, following Roux-en-Y gastric bypass (RYGB) surgery, a small minority of patients develop new-onset alcohol use disorder (AUD), the aetiology of which is poorly understood. AIM: The aim is to construct a theory to explain the development of AUD among a sample of individuals who reported problematic drinking following RYGB. METHOD: Semi-structured interviews were conducted with eight RYGB patients diagnosed with AUD attending a multi-disciplinary outpatient weight management service at a public hospital in the Republic of Ireland...
March 2018: Obesity Surgery
https://www.readbyqxmd.com/read/28980219/persistent-endocrine-disrupting-chemicals-and-fatty-liver-disease
#13
REVIEW
Andrea L Deierlein, Sarah Rock, Sally Park
PURPOSE OF REVIEW: Non-alcoholic fatty liver disease (NAFLD) is the most prominent chronic liver disease in Western countries, affecting approximately 25% of the population worldwide. Sex-specific differences in the development of NAFLD are apparent. While obesity and insulin resistance are major contributors to the increasing prevalence of NAFLD, a growing body of literature suggests that exposure to persistent endocrine-disrupting chemicals (pEDCs) may also play a role. This review summarizes recent (2011 and later) scientific literature investigating exposures to pEDCs, specifically persistent organic pollutants (POPs), and NAFLD, with a focus on sex-specific associations...
December 2017: Current Environmental Health Reports
https://www.readbyqxmd.com/read/28958273/variation-in-clinical-characteristics-of-women-versus-men-preoperative-for-laparoscopic-roux-en-y-gastric-bypass-analysis-of-83-059-patients
#14
COMPARATIVE STUDY
Jandie Schwartz, Christopher Bashian, Leon Kushnir, Cristina Nituica, Gus J Slotman
Variation by sex in preoperative clinical characteristics of female and male laparoscopic Roux-en-Y gastric bypass (LRYGB) patients has not been evaluated comprehensively. The objective of our study was to identify clinical differences between morbidly obese women and men seeking LRYGB. Data from 83,059 patients in the Surgical Review Corporation's Bariatric Outcomes Longitudinal Database who were about to undergo LRYGB was analyzed in two groups: women (n = 65,325) and men (n = 17,734). Statistics were evaluated with analysis of variance and the χ2 equation...
September 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28869021/-acute-impact-of-the-small-intestine-in-a-patient-after-gastric-bypass-surgery-and-alcohol-intake
#15
Thomas Korgaard Jensen
This case recounts the management of a patient, who had previously undergone laparoscopic gastric bypass surgery and was admitted with sudden onset of severe abdominal pain. A computed tomography suggested acute ischaemia of the Roux limb. A normal diagnostic laparoscopy was performed, and a subsequent upper endoscopy showed a severely inflamed Roux limb. The patient informed that he had accidentally ingested a single glass of strong liquor. The endoscopy was repeated a month after discharge and was normal...
August 21, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28846948/biopsy-proven-progressive-fatty-liver-disease-nine-months-post-mini-gastric-bypass-surgery-a-case-study
#16
Mohammad Ali Kalantar Motamedi, Nasser Rakhshani, Alireza Khalaj, Maryam Barzin
INTRODUCTION: Mini-gastric bypass (MGB) is a popular bariatric procedure. Its effect on non-alcoholic fatty liver disease (NAFLD), however, has not yet been comprehensively studied. PRESENTATION OF CASE: A 57 year-old non-alcoholic female with a body mass index of 42.8kg/m(2) underwent MGB without any incident. A concurrent liver biopsy showed an NAFLD activity score (NAS) of 2/8 without fibrosis. She presented at postoperative month eight with edema, vague abdominal pain, nausea, and vomiting and was hospitalized...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28802901/effect-of-vertical-sleeve-gastrectomy-on-alcohol-consumption-and-preferences-in-dietary-obese-rats-and-mice-a-plausible-role-for-altered-ghrelin-signaling
#17
Elise R Orellana, Catherine Jamis, Nelli Horvath, Andras Hajnal
Vertical sleeve gastrectomy (VSG) and Roux-en-Y gastric bypass (RYGB) are the most common surgical options for the treatment of obesity and metabolic disorder. Whereas RYGB may result in greater and more durable weight loss, recent clinical and pre-clinical studies in rats have raised concerns that RYGB surgery may increase risk for alcohol use disorder (AUD). In contrast, recent clinical reports suggest a lesser risk for AUD following VSG, although no preclinical studies have been done to confirm that. Therefore, the present study sought to determine the effects of VSG on ethanol intake and preferences in rodent models using protocols similar to those previously used in animal studies for RYGB...
August 9, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28767558/liver-function-in-patients-with-nonalcoholic-fatty-liver-disease-randomized-to-roux-en-y-gastric-bypass-versus-sleeve-gastrectomy-a-secondary-analysis-of-a-randomized-clinical-trial
#18
RANDOMIZED CONTROLLED TRIAL
Piotr Kalinowski, Rafał Paluszkiewicz, Bogna Ziarkiewicz-Wróblewska, Tadeusz Wróblewski, Piotr Remiszewski, Mariusz Grodzicki, Marek Krawczyk
OBJECTIVES: The aim of the study was to compare the influence of sleeve gastrectomy (SG) versus Roux-en-Y gastric bypass (RYGB) on liver function in bariatric patients with non-alcoholic fatty liver disease (NAFLD) in a randomized clinical trial (NCT01806506). BACKGROUND: Rapid weight loss and malabsorption after bariatric surgery in patients with NAFLD or steatohepatitis (NASH) may impair liver function. METHODS: Sixty-six morbidly obese patients randomized to SG or RYGB were included in a secondary outcome analysis...
November 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28756049/sociodemographic-and-lifestyle-factors-as-determinants-of-energy-intake-and-macronutrient-composition-a-10-year-follow-up-after-bariatric-surgery
#19
Noora Kanerva, Ingrid Larsson, Markku Peltonen, Anna-Karin Lindroos, Lena M Carlsson
BACKGROUND: Early identification of the potential to adopt a long-term unhealthy diet, could improve weight outcomes for patients having undergone bariatric surgery. OBJECTIVES: We explored whether presurgical sociodemographic and lifestyle characteristics, together with the type of surgery, could predict 10-year changes in dietary intake after bariatric surgery. SETTING: Surgical departments and primary healthcare centers, nationwide. METHODS: Participants were from the Swedish Obese Subjects study, a matched (nonrandomized) prospective trial comparing bariatric surgery with standard care for obese patients...
September 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28752920/outcome-of-liver-transplantation-in-patients-with-prior-bariatric-surgery
#20
Mohamed Safwan, Kelly M Collins, Marwan S Abouljoud, Reena Salgia
Nonalcoholic fatty liver disease is becoming the leading cause of disease resulting in liver transplantation (LT). As a result of this trend, more LT candidates are presenting with prior history of bariatric surgery (BS). Over the last decade, 960 patients underwent LT at our institution; 11 (1.1%) had prior BS. The most common type of BS was Roux-en-Y gastric bypass (n = 9) with 1 sleeve gastrectomy and 1 jejunoileal bypass. A total of 9 patients underwent LT alone, and 2 underwent simultaneous liver-kidney transplantation...
November 2017: Liver Transplantation
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