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https://www.readbyqxmd.com/read/28429199/gastric-bypass-and-influence-on-improvement-of-nafld
#1
REVIEW
Vamsi Alli, Ann M Rogers
PURPOSE OF REVIEW: Obesity is recognized as a chronic and recurring disease, often accompanied by other weight-related comorbid conditions such as obstructive sleep apnea, hypertension, type 2 diabetes, and non-alcoholic fatty liver disease (NAFLD). This chapter will seek to focus on the effect of weight loss surgery (WLS), in particular Roux-en-Y gastric bypass (RYGB), on NAFLD. RECENT FINDINGS: Among several modalities available to treat NAFLD, the one most likely to achieve rapid, significant, and sustained improvement of liver disease is WLS...
June 2017: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/28350154/-wernicke-encephalopathy-and-dry-beriberi-late-complications-after-bariatric-surgery-performed-on-a-patient-with-a-psychiatric-history
#2
G E M Penders, I M Daey Ouwens, F M M A van der Heijden
A 38-year-old woman was admitted in a psychiatric hospital because of memory disorders. Dry beriberi and Korsakoff's syndrome, as a late neuropsychiatric manifestation of Wernicke's encephalopathy, were established. The beriberi symptoms decreased slowly, but the patient's memory impairments persisted. These clinical features were caused by a thiamine deficiency. Gastric bypass surgery is associated with an increased risk of thiamine deficiency. Excessive alcohol consumption and poor compliance with vitamin deficiency treatment both contributed to the rapid onset of these disorders...
2017: Tijdschrift Voor Psychiatrie
https://www.readbyqxmd.com/read/28277977/human-liver-epigenetic-alterations-in-non-alcoholic-steatohepatitis-are-related-to-insulin-action
#3
Vanessa D de Mello, Ashok Matte, Alexander Perfilyev, Ville Männistö, Tina Rönn, Emma Nilsson, Pirjo Käkelä, Charlotte Ling, Jussi Pihlajamäki
Both genetic and lifestyle factors contribute to the risk of non-alcoholic steatohepatitis (NASH). Additionally, epigenetic modifications may also play a key role in the pathogenesis of NASH. We therefore investigated liver DNA methylation, as a marker for epigenetic alterations, in individuals with simple steatosis and NASH, and further tested if these alterations were associated with clinical phenotypes. Liver biopsies obtained from 95 obese individuals (age: 49.5 ± 7.7 years, BMI: 43 ± 5.7 kg/m(2), type 2 diabetes [T2D]: 35) as a wedge biopsy during a Roux-en-Y gastric bypass operation were investigated...
April 3, 2017: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/28256569/aggressive-non-alcoholic-steatohepatitis-following-rapid-weight-loss-and-or-malnutrition
#4
Jia-Huei Tsai, Linda D Ferrell, Vivian Tan, Matthew M Yeh, Monika Sarkar, Ryan M Gill
While non-alcoholic steatohepatitis is a slowly progressive disease, patients may rarely present in acute liver failure. We describe six patients who developed severe hepatic dysfunction following rapid weight loss or malnutrition. Rapid weight loss (18 to 91 kg) occurred after Roux-en-Y gastric bypass in four patients and starvation-like dieting or hypoalbuminemia was noted in two patients. Four patients either died or received an urgent liver transplant. Pathologic findings were characterized by advanced alcoholic steatohepatitis-like features, including extensive/circumferential centrizonal pericellular fibrosis, central scar with perivenular sclerosis/veno-occlusion with superimposed hepatocellular dropout, abundant/prominent hepatocellular balloons, and numerous Mallory-Denk bodies, but there was no history of excess alcohol consumption...
March 3, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28215312/prevalence-of-clinical-thiamine-deficiency-in-individuals-with-medically-complicated-obesity
#5
Anand Nath, Tung Tran, Timothy R Shope, Timothy R Koch
Thiamine is a vitamin whose deficient can result in multiorgan symptoms. We described an 18% prevalence of clinical thiamine deficiency after gastric bypass surgery. Our hypotheses are that individuals with medically complicated obesity frequently have clinical thiamine deficiency and that diabetes mellitus is a mechanism for development of clinical thiamine deficiency. This is a single institution, retrospective observational study of consecutive patients with a body mass index of at least 35 kg/m(2) who were evaluated in preoperative gastrointestinal bariatric clinic from 2013 to 2015...
January 2017: Nutrition Research
https://www.readbyqxmd.com/read/28088126/severe-hypoalbuminemia-and-steatohepatitis-leading-to-death-in-a-young-vegetarian-female-8-months-after-mini-gastric-bypass-a-case-report
#6
Mohammad Kermansaravi, Mohammad Reza Abdolhosseini, Ali Kabir, Abdolreza Pazouki
BACKGROUND: Hypoalbuminemia is an important complication after Mini Gastric Bypass (MGB) and is more frequent in vegetarians, diabetic nephropathy, and alcoholic and liver disease patients. The patients must be followed in regular intervals and serum albumin must be checked in every visit after MGB. Hypoalbuminemia must be prevented by good protein regimes. CASE SUMMARY: A 29 years old female was admitted 8 month after Laparoscopic Mini Gastric Bypass with malaise, dyspnea, icter, nausea, vomiting, diarrhea and edema of extremities from 2 weeks before admission...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28064372/effects-of-bariatric-surgery-on-non-alcoholic-fatty-liver-disease-magnetic-resonance-imaging-is-an-effective-non-invasive-method-to-evaluate-changes-in-the-liver-fat-fraction
#7
Dennis M Hedderich, Till Hasenberg, Stefan Haneder, Stefan O Schoenberg, Özlem Kücükoglu, Ali Canbay, Mirko Otto
INTRODUCTION: Non-alcoholic fatty liver disease (NAFLD) is considered the most common liver disease worldwide and is highly associated with obesity. The prevalences of both conditions have markedly increased in the Western civilization. Bariatric surgery is the most effective treatment for morbid obesity and its comorbidities such as NAFLD. OBJECTIVES: Measure postoperative liver fat fraction (LFF) in bariatric patients by using in-opposed-phase MRI, a widely available clinical tool validated for the quantification of liver fat METHODS: Retrospective analyses of participants, who underwent laparoscopic Roux-Y-gastric-bypass (17) or laparoscopic sleeve gastrectomy (2) were performed using magnetic resonance imaging (MRI), bioelectrical impedance analysis (BIA), and anthropometric measurements 1 day before surgery, as well as 6, 12, and 24 weeks after surgery, LFF was calculated from fat-only and water-only MR images...
January 7, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/27997471/rate-of-acute-hospital-admissions-before-and-after-roux-en-y-gastric-bypass-surgery-a-population-based-cohort-study
#8
Sigrid Bjerge Gribsholt, Elisabeth Svensson, Bjørn Richelsen, Uffe Raundahl, Henrik Toft Sørensen, Reimar Wernich Thomsen
OBJECTIVE: To examine rates of acute inpatient hospital admissions patients undergoing Roux-en-Y gastric bypass (RYGB) surgery and a matched population-based comparison cohort. SUMMARY BACKGROUND DATA: Little is known about the admission rates before and after RYGB. METHODS: Nationwide population-based cohort study, including all 9985 patients undergoing RYGB in Denmark during 2006 to 2010, and 247,375 matched general population comparisons...
December 16, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27874326/alcohol-use-patterns-and-alcohol-use-disorders-among-young-adult-ethnically-diverse-bariatric-surgery-patients
#9
Christine E Spadola, Eric F Wagner, Veronica H Accornero, Denise C Vidot, Nestor de la Cruz-Munoz, Sarah E Messiah
BACKGROUND: Research suggests that young adults and racial/ethnic minorities are at an increased risk for problematic alcohol use. Recent studies have also documented patterns of problematic alcohol use among a subset of weight loss surgery (WLS) patients. However, to date, there are no published studies investigating the intersection of these demographic and clinical characteristics. METHODS: This study used descriptive and inferential analyses to examine alcohol use patterns, prevalence of pre- and post-WLS alcohol use disorders (AUDs), and predictors of increased alcohol use and problematic alcohol use post-WLS among young adult (mean age 26...
January 2017: Substance Abuse
https://www.readbyqxmd.com/read/27837387/vitamin-d3-loading-is-superior-to-conventional-supplementation-after-weight-loss-surgery-in-vitamin-d-deficient-morbidly-obese-patients-a-double-blind-randomized-placebo-controlled-trial
#10
Maria Luger, Renate Kruschitz, Christian Kienbacher, Stefan Traussnigg, Felix B Langer, Gerhard Prager, Karin Schindler, Enikö Kallay, Friedrich Hoppichler, Michael Trauner, Michael Krebs, Rodrig Marculescu, Bernhard Ludvik
BACKGROUND: Bariatric patients often suffer from vitamin D deficiency (VDD), and both, morbid obesity and VDD, are related to non-alcoholic fatty liver disease. However, limited data are available regarding best strategies for treating VDD, particularly, in bariatric patients undergoing omega-loop gastric bypass (OLGB). Therefore, we examined the efficacy and safety of a forced vitamin D dosing regimen and intervention effects in liver fibrotic patients. METHODS: In this double-blind, randomized, placebo-controlled trial, 50 vitamin D-deficient patients undergoing OLGB were randomly assigned to receive, in the first month postoperatively, oral vitamin D3 (≤3 doses of 100,000 IU; intervention group) or placebo as loading dose (control group) with subsequent maintenance dose (3420 IU/day) in both groups until 6-month visit...
May 2017: Obesity Surgery
https://www.readbyqxmd.com/read/27812789/serum-plant-sterols-associate-with-gallstone-disease-independent-of-weight-loss-and-non-alcoholic-fatty-liver-disease
#11
Pirjo Käkelä, Ville Männistö, Imre Ilves, Maija Vaittinen, Milla-Maria Tauriainen, Matti Eskelinen, Helena Gylling, Hannu Paajanen, Jussi Pihlajamäki
BACKGROUND: Gallstone disease (GD) has been associated with low serum levels of plant sterols. We evaluated the impact of laparoscopic Roux-en-Y gastric bypass (LRYGB) and non-alcoholic fatty liver disease (NAFLD) on the association of GD with low levels of serum plant sterols. METHODS: Two hundred forty-two consecutive morbidly obese patients were recruited to this prospective study. Histological analysis of liver biopsy to diagnose NAFLD was performed. Bile sample was taken during the LRYGB...
May 2017: Obesity Surgery
https://www.readbyqxmd.com/read/27744735/energy-intake-and-food-habits-between-weight-maintainers-and-regainers-five-years-after-roux-en-y-gastric-bypass
#12
Ryan E R Reid, Ekaterina Oparina, Hugues Plourde, Ross E Andersen
We explored differences in dietary behaviours, energy, and macronutrient intake among individuals who had regained or maintained weight loss 5 or more years after Roux-en-Y gastric bypass (RYGB). This study assessed 27 adults who underwent RYGB an average of 12.1 ± 3.7 years before this study was conducted. Dietary assessment was performed using 3-day food records. Daily energy intake (kcal), protein (g), carbohydrate (g), fat (g), and alcohol intake (g) were computed using the ESHA's Food Processor(®). Participants were classified by percent weight loss, maintainers (≥38 %), and regainers (≤30 %)...
December 2016: Canadian Journal of Dietetic Practice and Research
https://www.readbyqxmd.com/read/27683790/the-alcohol-consumption-is-amended-after-bariatric-surgery-an-integrative-review
#13
Valeria Duarte Gregorio, Roselma Lucchese, Ivânia Vera, Graciele C Silva, Andrecia Silva, Rayrane Clarah Chaveiro Moraes
Background: Bariatric surgery has been an alternative when conservative methods of weight loss fail. Patients undergoing bariatric surgery have an increased risk of up to 6.5% of problems related to alcohol. Objective: Integrative review out to analyze the change of alcohol consumption in this public. Method: Database was accessed from June of 2015 to January of 2016 by searching "bariatric surgery" AND "alcoholism", and their Portuguese equivalents...
2016: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/27683779/serum-vitamin-b12-iron-and-folic-acid-deficiencies-in-obese-individuals-submitted-to-different-bariatric-techniques
#14
Rafaella de Andrade Silva, Flávia Monteiro França Malta, Maria Flora Ferreira Sampaio Carvalho Correia, Maria Goretti Pessoa de Araújo Burgos
Background: Different surgical techniques to combat obesity combine malabsorption with restrictive procedures and can lead to metabolic problems, such as micronutrient deficiencies. Aim: Assess vitamin B12, iron and folic acid deficiencies associated with the lifestyle of obese individuals having been submitted to different bariatric techniques. Methods: A retrospective analysis was performed using the electronic charts of patients submitted to bariatric surgery involving adjustable gastric banding and Roux-en-Y gastric bypass at the São João Hospital Center in the city of Porto, Portugal, between 2005 and 2010...
2016: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/27627078/-hypoglycemia-as-a-symptom-of-cancer-in-adults
#15
Zdeněk Fryšák, David Karásek
UNLABELLED: Decrease of blood glucose levels below 3 mmol/l is in fully developed cases accompanied by neuroglycopenic symptoms that may even lead to altered state of consciousness. The treating physician frequently faces a complicated situation. This may be due to inappropriately administered drugs including cases motivated by self-harm intentions (insulin, insulin secretagogues), or alcohol abuse. Undernourished people, or those afflicted with a serious systemic infection, end-stage liver or kidney diseases or with a failing heart, belong to a risk group...
2016: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27594839/roux-en-y-gastric-bypass-results-in-long-term-remission-of-hepatocyte-apoptosis-and-hepatic-histological-features-of-non-alcoholic-steatohepatitis
#16
Anne-Sophie Schneck, Rodolphe Anty, Stéphanie Patouraux, Stéphanie Bonnafous, Déborah Rousseau, Cynthia Lebeaupin, Beatrice Bailly-Maitre, Arnaud Sans, Albert Tran, Jean Gugenheim, Antonio Iannelli, Philippe Gual
The long-term effects of bariatric surgery on non-alcoholic steatohepatitis (NASH), focusing on liver injury and hepatocyte apoptosis, are not well-established. We here performed a longitudinal study with paired liver biopsies of nine morbidly obese women (median BMI: 42 [38.7; 45.1] kg/m(2)) with NASH with a median follow-up of 55 [44; 75] months after laparoscopic Roux-en-Y gastric bypass (LRYGB) surgery. LRYGB surgery was associated with significant weight loss (median BMI loss -13.7 [-16.4; -9.5] kg/m(2)), improved hepatic steatosis in all patients (55...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27508205/comparing-outcomes-of-two-types-of-bariatric-surgery-in-an-adolescent-obese-population-roux-en-y-gastric-bypass-vs-sleeve-gastrectomy
#17
Giovana D Maffazioli, Fatima Cody Stanford, Karen J Campoverde Reyes, Takara L Stanley, Vibha Singhal, Kathleen E Corey, Janey S Pratt, Miriam A Bredella, Madhusmita Misra
BACKGROUND: Obesity is prevalent among adolescents and is associated with serious health consequences. Roux-en-Y Gastric Bypass (RYGB) and Sleeve Gastrectomy (SG) are bariatric procedures that cause significant weight loss in adults and are increasingly being performed in adolescents with morbid obesity. Data comparing outcomes of RYGB vs. SG in this age-group are scarce. This study aims to compare short-term (1-6 months) and longer-term (7-18 months) body mass index (BMI) and biochemical outcomes following RYGB and SG in adolescents/young adults...
2016: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/27467694/alcohol-and-substance-abuse-depression-and-suicide-attempts-after-roux-en-y-gastric-bypass-surgery
#18
O Backman, D Stockeld, F Rasmussen, E Näslund, R Marsk
BACKGROUND: Small studies suggest that subjects who have undergone bariatric surgery are at increased risk of suicide, alcohol and substance use disorders. This population-based cohort study aimed to assess the incidence of treatment for alcohol and substance use disorders, depression and attempted suicide after primary Roux-en-Y gastric bypass (RYGB). METHODS: All patients who underwent primary RYGB in Sweden between 2001 and 2010 were included. Incidence of hospital admission for alcohol and substance use disorders, depression and suicide attempt was measured, along with the number of drugs prescribed...
September 2016: British Journal of Surgery
https://www.readbyqxmd.com/read/27440167/radiographic-improvement-of-hepatic-steatosis-after-laparoscopic-roux-en-y-gastric-bypass
#19
Joshua S Winder, Brandon S Dudeck, Sarayna Schock, Jerome R Lyn-Sue, Randy S Haluck, Ann M Rogers
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is the most common form of liver disease and the leading cause of cirrhosis in developed nations. Studies confirm improvement of liver histopathology after significant weight loss, but biochemistry and sonography do not always show this. Computed tomographic (CT) findings of NAFLD include low attenuation of liver parenchyma and hepatomegaly. We hypothesized that patients experiencing significant weight loss after laparoscopic Roux-en-Y gastric bypass (LRYGB) would show CT improvement of NAFLD...
July 20, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27381560/monitoring-of-liver-function-tests-after-roux-en-y-gastric-bypass-an-examination-of-evidence-base
#20
REVIEW
Kamal K Mahawar, Chetan Parmar, Yitka Graham, Nimantha De Alwis, William R J Carr, Neil Jennings, Peter K Small
There is no consensus on the monitoring of liver function tests after Roux-en-Y gastric bypass (RYGB). Since the main objective of such monitoring would be to diagnose early those who will eventually develop liver failure after RYGB, we performed a systematic review on this topic. An extensive search of literature revealed only 10 such cases in 6 published articles. It would hence appear that liver failure is a rare problem after RYGB. Routine lifelong monitoring of liver function tests is therefore unnecessary for otherwise asymptomatic individuals...
October 2016: Obesity Surgery
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