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https://www.readbyqxmd.com/read/29119336/bariatric-surgery-as-an-efficient-treatment-for-non-alcoholic-fatty-liver-disease-in-a-prospective-study-with-1-year-follow-up-bariscan-study
#1
Felix Nickel, Christian Tapking, Laura Benner, Janina Sollors, Adrian T Billeter, Hannes G Kenngott, Loay Bokhary, Mathias Schmid, Moritz von Frankenberg, Lars Fischer, Sebastian Mueller, Beat P Müller-Stich
BACKGROUND: Bariatric surgery gains attention as a potential treatment for non-alcoholic fatty liver disease (NAFLD). The present study aimed to evaluate improvement of NAFLD after the two most common bariatric procedures with validated non-invasive instruments. MATERIAL AND METHODS: N = 100 patients scheduled for laparoscopic sleeve gastrectomy (LSG) or Roux-en-Y gastric bypass (RYGB) were included. NAFLD was evaluated preoperatively and postoperatively with liver stiffness measurement by transient elastography and laboratory-based fibrosis scores...
November 9, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29110243/problematic-alcohol-use-and-associated-characteristics-following-bariatric-surgery
#2
Kathryn E Smith, Scott G Engel, Kristine J Steffen, Luis Garcia, Karen Grothe, Afton Koball, James E Mitchell
PURPOSE: Evidence suggests that a significant minority of individuals who undergo Roux-en-Y gastric bypass (RYGB) experience problematic alcohol and substance use following surgery. However, little research has examined characteristics, drinking patterns, and possible risk factors within this population. To provide descriptive information of a sample of adults with self-identified alcohol use problems following bariatric surgery, this study examined (1) alcohol and substance use symptoms using standardized assessments, (2) current and past psychiatric comorbidity, (3) subjective changes in alcohol sensitivity following surgery, and (4) specific patterns of alcohol use prior to and following bariatric surgery...
November 6, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29032488/how-do-individuals-develop-alcohol-use-disorder-after-bariatric-surgery-a-grounded-theory-exploration
#3
Ruth Yoder, Padraig MacNeela, Ronan Conway, Caroline Heary
BACKGROUND: Bariatric surgery is the most effective treatment for severe obesity. However, following Roux-en-Y gastric bypass (RYGB) surgery, a small minority of patients develop new-onset alcohol use disorder (AUD), the aetiology of which is poorly understood. AIM: The aim is to construct a theory to explain the development of AUD among a sample of individuals who reported problematic drinking following RYGB. METHOD: Semi-structured interviews were conducted with eight RYGB patients diagnosed with AUD attending a multi-disciplinary outpatient weight management service at a public hospital in the Republic of Ireland...
October 14, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28980219/persistent-endocrine-disrupting-chemicals-and-fatty-liver-disease
#4
REVIEW
Andrea L Deierlein, Sarah Rock, Sally Park
PURPOSE OF REVIEW: Non-alcoholic fatty liver disease (NAFLD) is the most prominent chronic liver disease in Western countries, affecting approximately 25% of the population worldwide. Sex-specific differences in the development of NAFLD are apparent. While obesity and insulin resistance are major contributors to the increasing prevalence of NAFLD, a growing body of literature suggests that exposure to persistent endocrine-disrupting chemicals (pEDCs) may also play a role. This review summarizes recent (2011 and later) scientific literature investigating exposures to pEDCs, specifically persistent organic pollutants (POPs), and NAFLD, with a focus on sex-specific associations...
December 2017: Current Environmental Health Reports
https://www.readbyqxmd.com/read/28958273/variation-in-clinical-characteristics-of-women-versus-men-preoperative-for-laparoscopic-roux-en-y-gastric-bypass-analysis-of-83-059-patients
#5
COMPARATIVE STUDY
Jandie Schwartz, Christopher Bashian, Leon Kushnir, Cristina Nituica, Gus J Slotman
Variation by sex in preoperative clinical characteristics of female and male laparoscopic Roux-en-Y gastric bypass (LRYGB) patients has not been evaluated comprehensively. The objective of our study was to identify clinical differences between morbidly obese women and men seeking LRYGB. Data from 83,059 patients in the Surgical Review Corporation's Bariatric Outcomes Longitudinal Database who were about to undergo LRYGB was analyzed in two groups: women (n = 65,325) and men (n = 17,734). Statistics were evaluated with analysis of variance and the χ2 equation...
September 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28869021/-acute-impact-of-the-small-intestine-in-a-patient-after-gastric-bypass-surgery-and-alcohol-intake
#6
Thomas Korgaard Jensen
This case recounts the management of a patient, who had previously undergone laparoscopic gastric bypass surgery and was admitted with sudden onset of severe abdominal pain. A computed tomography suggested acute ischaemia of the Roux limb. A normal diagnostic laparoscopy was performed, and a subsequent upper endoscopy showed a severely inflamed Roux limb. The patient informed that he had accidentally ingested a single glass of strong liquor. The endoscopy was repeated a month after discharge and was normal...
August 21, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28846948/biopsy-proven-progressive-fatty-liver-disease-nine-months-post-mini-gastric-bypass-surgery-a-case-study
#7
Mohammad Ali Kalantar Motamedi, Nasser Rakhshani, Alireza Khalaj, Maryam Barzin
INTRODUCTION: Mini-gastric bypass (MGB) is a popular bariatric procedure. Its effect on non-alcoholic fatty liver disease (NAFLD), however, has not yet been comprehensively studied. PRESENTATION OF CASE: A 57 year-old non-alcoholic female with a body mass index of 42.8kg/m(2) underwent MGB without any incident. A concurrent liver biopsy showed an NAFLD activity score (NAS) of 2/8 without fibrosis. She presented at postoperative month eight with edema, vague abdominal pain, nausea, and vomiting and was hospitalized...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28802901/effect-of-vertical-sleeve-gastrectomy-on-alcohol-consumption-and-preferences-in-dietary-obese-rats-and-mice-a-plausible-role-for-altered-ghrelin-signaling
#8
Elise R Orellana, Catherine Jamis, Nelli Horvath, Andras Hajnal
Vertical sleeve gastrectomy (VSG) and Roux-en-Y gastric bypass (RYGB) are the most common surgical options for the treatment of obesity and metabolic disorder. Whereas RYGB may result in greater and more durable weight loss, recent clinical and pre-clinical studies in rats have raised concerns that RYGB surgery may increase risk for alcohol use disorder (AUD). In contrast, recent clinical reports suggest a lesser risk for AUD following VSG, although no preclinical studies have been done to confirm that. Therefore, the present study sought to determine the effects of VSG on ethanol intake and preferences in rodent models using protocols similar to those previously used in animal studies for RYGB...
August 9, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28767558/liver-function-in-patients-with-nonalcoholic-fatty-liver-disease-randomized-to-roux-en-y-gastric-bypass-versus-sleeve-gastrectomy-a-secondary-analysis-of-a-randomized-clinical-trial
#9
RANDOMIZED CONTROLLED TRIAL
Piotr Kalinowski, Rafał Paluszkiewicz, Bogna Ziarkiewicz-Wróblewska, Tadeusz Wróblewski, Piotr Remiszewski, Mariusz Grodzicki, Marek Krawczyk
OBJECTIVES: The aim of the study was to compare the influence of sleeve gastrectomy (SG) versus Roux-en-Y gastric bypass (RYGB) on liver function in bariatric patients with non-alcoholic fatty liver disease (NAFLD) in a randomized clinical trial (NCT01806506). BACKGROUND: Rapid weight loss and malabsorption after bariatric surgery in patients with NAFLD or steatohepatitis (NASH) may impair liver function. METHODS: Sixty-six morbidly obese patients randomized to SG or RYGB were included in a secondary outcome analysis...
November 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28756049/sociodemographic-and-lifestyle-factors-as-determinants-of-energy-intake-and-macronutrient-composition-a-10-year-follow-up-after-bariatric-surgery
#10
Noora Kanerva, Ingrid Larsson, Markku Peltonen, Anna-Karin Lindroos, Lena M Carlsson
BACKGROUND: Early identification of the potential to adopt a long-term unhealthy diet, could improve weight outcomes for patients having undergone bariatric surgery. OBJECTIVES: We explored whether presurgical sociodemographic and lifestyle characteristics, together with the type of surgery, could predict 10-year changes in dietary intake after bariatric surgery. SETTING: Surgical departments and primary healthcare centers, nationwide. METHODS: Participants were from the Swedish Obese Subjects study, a matched (nonrandomized) prospective trial comparing bariatric surgery with standard care for obese patients...
September 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28752920/outcome-of-liver-transplantation-in-patients-with-prior-bariatric-surgery
#11
Mohamed Safwan, Kelly M Collins, Marwan S Abouljoud, Reena Salgia
Non-alcoholic fatty liver disease is becoming the leading cause of disease resulting in liver transplantation (LT). As a result of this trend, more liver transplant candidates are presenting with prior history of bariatric surgery (BS). Over the last decade, 960 patients underwent LT at our institution; 11 (1.1%) had prior BS. Most common type of BS was Roux-en-Y gastric bypass (n=9) with 1 sleeve gastrectomy and 1 jejunoileal bypass. Nine patients underwent LT alone and 2 underwent simultaneous liver-kidney transplantation...
July 28, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28550439/baseline-anthropometric-and-metabolic-parameters-correlate-with-weight-loss-in-women-1-year-after-laparoscopic-roux-en-y-gastric-bypass
#12
Arnaud Sans, Laurent Bailly, Rodolphe Anty, Igor Sielezenef, Jean Gugenheim, Albert Tran, Philippe Gual, Antonio Iannelli
BACKGROUND: In this study, we explored in a prospective cohort of morbidly obese women undergoing laparoscopic Roux-en-Y gastric bypass (LRYGP) correlations between baseline anthropometrics, metabolic parameters, resting energy expenditure (REE), body composition, and 1-year % excess body mass index loss (%EBMIL). We also investigated risk factors for insufficient %EBMIL. METHODS: One hundred three consecutive women were prospectively evaluated at baseline (age 40...
November 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28528115/alcohol-and-other-substance-use-after-bariatric-surgery-prospective-evidence-from-a-u-s-multicenter-cohort-study
#13
Wendy C King, Jia-Yuh Chen, Anita P Courcoulas, Gregory F Dakin, Scott G Engel, David R Flum, Marcelo W Hinojosa, Melissa A Kalarchian, Samer G Mattar, James E Mitchell, Alfons Pomp, Walter J Pories, Kristine J Steffen, Gretchen E White, Bruce M Wolfe, Susan Z Yanovski
BACKGROUND: Empirical evidence suggests Roux-en-Y gastric bypass (RYGB) increases risk of developing alcohol use disorder (AUD). However, prospective assessment of substance use disorders (SUD) after bariatric surgery is limited. OBJECTIVE: To report SUD-related outcomes after RYGB and laparoscopic adjustable gastric banding (LAGB). To identify factors associated with incident SUD-related outcomes. SETTING: 10 U.S. hospitals METHODS: The Longitudinal Assessment of Bariatric Surgery-2 is a prospective cohort study...
August 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28500684/impact-of-roux-en-y-gastric-bypass-surgery-on-appetite-alcohol-intake-behaviors-and-midbrain-ghrelin-signaling-in-the-rat
#14
Sunil Sirohi, Ben D Richardson, Janelle M Lugo, David J Rossi, Jon F Davis
OBJECTIVE: Roux-en-Y gastric bypass (RYGB) surgery reduces appetite and stimulates new onset alcohol misuse; however, the genesis of these behavioral changes is unclear. This study is hypothesized that new onset alcohol intake is a behavioral adaptation that occurs secondary to reduced appetite and correlates with altered central ghrelin signaling. METHODS: Hedonic high-fat diet (HFD) intake was evaluated prior to the assessment of alcohol intake behaviors in RYGB and control rats...
May 12, 2017: Obesity
https://www.readbyqxmd.com/read/28500418/weight-loss-after-bariatric-surgery-do-clinical-and-behavioral-factors-explain-racial-differences
#15
Christina C Wee, Daniel B Jones, Caroline Apovian, Donald T Hess, Sarah N Chiodi, Ashley C Bourland, Roger B Davis, Benjamin Schneider, George L Blackburn, Edward R Marcantonio, Mary Beth Hamel
BACKGROUND: Prior studies have suggested less weight loss among African American compared to Caucasian patients; however, few studies have been able to simultaneously account for baseline differences in other demographic, clinical, or behavioral factors. METHODS: We interviewed patients at two weight loss surgery (WLS) centers and conducted chart reviews before and after WLS. We compared weight loss post-WLS by race/ethnicity and examined baseline demographic, clinical (BMI, comorbidities, quality of life), and behavioral (eating behavior, physical activity level, alcohol intake) factors that might explain observed racial differences in weight loss at 1 and 2 years after WLS...
November 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28429199/gastric-bypass-and-influence-on-improvement-of-nafld
#16
REVIEW
Vamsi Alli, Ann M Rogers
PURPOSE OF REVIEW: Obesity is recognized as a chronic and recurring disease, often accompanied by other weight-related comorbid conditions such as obstructive sleep apnea, hypertension, type 2 diabetes, and non-alcoholic fatty liver disease (NAFLD). This chapter will seek to focus on the effect of weight loss surgery (WLS), in particular Roux-en-Y gastric bypass (RYGB), on NAFLD. RECENT FINDINGS: Among several modalities available to treat NAFLD, the one most likely to achieve rapid, significant, and sustained improvement of liver disease is WLS...
June 2017: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/28350154/-wernicke-encephalopathy-and-dry-beriberi-late-complications-after-bariatric-surgery-performed-on-a-patient-with-a-psychiatric-history
#17
G E M Penders, I M Daey Ouwens, F M M A van der Heijden
A 38-year-old woman was admitted in a psychiatric hospital because of memory disorders. Dry beriberi and Korsakoff's syndrome, as a late neuropsychiatric manifestation of Wernicke's encephalopathy, were established. The beriberi symptoms decreased slowly, but the patient's memory impairments persisted. These clinical features were caused by a thiamine deficiency. Gastric bypass surgery is associated with an increased risk of thiamine deficiency. Excessive alcohol consumption and poor compliance with vitamin deficiency treatment both contributed to the rapid onset of these disorders...
2017: Tijdschrift Voor Psychiatrie
https://www.readbyqxmd.com/read/28277977/human-liver-epigenetic-alterations-in-non-alcoholic-steatohepatitis-are-related-to-insulin-action
#18
Vanessa D de Mello, Ashok Matte, Alexander Perfilyev, Ville Männistö, Tina Rönn, Emma Nilsson, Pirjo Käkelä, Charlotte Ling, Jussi Pihlajamäki
Both genetic and lifestyle factors contribute to the risk of non-alcoholic steatohepatitis (NASH). Additionally, epigenetic modifications may also play a key role in the pathogenesis of NASH. We therefore investigated liver DNA methylation, as a marker for epigenetic alterations, in individuals with simple steatosis and NASH, and further tested if these alterations were associated with clinical phenotypes. Liver biopsies obtained from 95 obese individuals (age: 49.5 ± 7.7 years, BMI: 43 ± 5.7 kg/m(2), type 2 diabetes [T2D]: 35) as a wedge biopsy during a Roux-en-Y gastric bypass operation were investigated...
April 3, 2017: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/28256569/aggressive-non-alcoholic-steatohepatitis-following-rapid-weight-loss-and-or-malnutrition
#19
Jia-Huei Tsai, Linda D Ferrell, Vivian Tan, Matthew M Yeh, Monika Sarkar, Ryan M Gill
While non-alcoholic steatohepatitis is a slowly progressive disease, patients may rarely present in acute liver failure. We describe six patients who developed severe hepatic dysfunction following rapid weight loss or malnutrition. Rapid weight loss (18 to 91 kg) occurred after Roux-en-Y gastric bypass in four patients and starvation-like dieting or hypoalbuminemia was noted in two patients. Four patients either died or received an urgent liver transplant. Pathologic findings were characterized by advanced alcoholic steatohepatitis-like features, including extensive/circumferential centrizonal pericellular fibrosis, central scar with perivenular sclerosis/veno-occlusion with superimposed hepatocellular dropout, abundant/prominent hepatocellular balloons, and numerous Mallory-Denk bodies, but there was no history of excess alcohol consumption...
June 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28215312/prevalence-of-clinical-thiamine-deficiency-in-individuals-with-medically-complicated-obesity
#20
Anand Nath, Tung Tran, Timothy R Shope, Timothy R Koch
Thiamine is a vitamin whose deficient can result in multiorgan symptoms. We described an 18% prevalence of clinical thiamine deficiency after gastric bypass surgery. Our hypotheses are that individuals with medically complicated obesity frequently have clinical thiamine deficiency and that diabetes mellitus is a mechanism for development of clinical thiamine deficiency. This is a single institution, retrospective observational study of consecutive patients with a body mass index of at least 35 kg/m(2) who were evaluated in preoperative gastrointestinal bariatric clinic from 2013 to 2015...
January 2017: Nutrition Research
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