keyword
MENU ▼
Read by QxMD icon Read
search

Behavioral and Psychological Symptoms of Dementia

keyword
https://www.readbyqxmd.com/read/28815557/societal-and-family-lifetime-cost-of-dementia-implications-for-policy
#1
Eric Jutkowitz, Robert L Kane, Joseph E Gaugler, Richard F MacLehose, Bryan Dowd, Karen M Kuntz
OBJECTIVES: To estimate the cost of dementia and the extra cost of caring for someone with dementia over the cost of caring for someone without dementia. DESIGN: We developed an evidence-based mathematical model to simulate disease progression for newly diagnosed individuals with dementia. Data-driven trajectories of cognition, function, and behavioral and psychological symptoms were used to model disease progression and predict costs. Using modeling, we evaluated lifetime and annual costs of individuals with dementia, compared costs of those with and without clinical features of dementia, and evaluated the effect of reducing functional decline or behavioral and psychological symptoms by 10% for 12 months (implemented when Mini-Mental State Examination score ≤21)...
August 17, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28807433/influences-on-decision-making-regarding-antipsychotic-prescribing-in-nursing-home-residents-with-dementia-a-systematic-review-and-synthesis-of-qualitative-evidence
#2
REVIEW
Kieran A Walsh, Rebecca Dennehy, Carol Sinnott, John Browne, Stephen Byrne, Jennifer McSharry, Eoin Coughlan, Suzanne Timmons
BACKGROUND: Antipsychotic prescribing is prevalent in nursing homes for the management of behavioral and psychological symptoms of dementia (BPSD), despite the known risks and limited effectiveness. Many studies have attempted to understand this continuing phenomenon, using qualitative research methods, and have generated varied and sometimes conflicting findings. To date, the totality of this qualitative evidence has not been systematically collated and synthesized. AIMS: To synthesize the findings from individual qualitative studies on decision-making and prescribing behaviors for antipsychotics in nursing home residents with dementia, with a view to informing intervention development and quality improvement in this field...
August 11, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28807163/effect-of-chinese-herbal-medicine-on-alzheimer-s-disease
#3
Melanie-Jayne R Howes, Rui Fang, Peter J Houghton
Alzheimer's disease (AD) is reaching epidemic proportions yet treatment strategies are limited and are restricted to providing symptomatic relief for the cognitive and behavioral and psychological symptoms of dementia (BPSD). Chinese herbal medicine (CHM) has been a valuable source of medicines for centuries and research has burgeoned in recent years to understand the scientific basis for their use. Some plants have been used in CHM for AD symptoms (e.g., Polygala tenuifolia), while others are CHMs for different conditions, but they show mechanistic effects relevant to AD (e...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/28767205/prevalence-and-pharmacotherapy-of-behavioral-and-psychological-symptoms-of-dementia-in-a-geriatric-psychiatry-unit-a-retrospective-analysis
#4
Arnim Quante, Atdhe Sulejmani
Objective: To observe (1) the proportion and nature of behavioral and psychological symptoms of dementia (BPSD) in patients treated at a geriatric psychiatry ward in Germany over a time span of 1 year and (2) the use and effect of various pharmacologic interventions in managing BPSD in a real-world scenario. Methods: This study was a naturalistic, retrospective analysis. Between May 2015 and May 2016, 437 patients aged 65 to 100 years with various psychiatric diseases (including dementia, schizophrenia, and depression) were admitted to a geriatric psychiatry unit in Germany...
July 27, 2017: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/28763881/-efficacy-and-tolerance-of-memantine-monotherapy-and-combination-therapy-with-reinhartdt-and-sea-cucumber-capsule-on-agitation-in-moderate-to-severe-alzheimer-disease
#5
E Y Yu, Z L Liao, Y F Tan, Y J Qiu, J P Zhu, Y Chen, S S Lin, M H Wu
Objective: To explore the efficacy and tolerance of Memantine combined Reinhartdt And Sea Cucumber Capsule (R.S.C) on treating agitation in patients with moderate-severe Alzheimer disease (AD). Methods: One hundred and fifty-eight moderate-sever AD patients from Sep.2013 to Sep.2014 in Zhejiang Provincial People's Hospital were randomly divided into two groups: group of Memantine combined R. S.C and group of single Memantine. Then Mini-Mental Sate Examination (MMSE) and Neuropsychiatric Inventory (NPI) were used to evaluate cognition symptom, behavioral and psychological symptoms of dementia (BPSD) and agitation symptom at the baseline and the end of 24 weeks...
July 18, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28763213/novel-3-1-2-3-6-tetrahydropyridin-4-yl-1h-indole-based-multifunctional-ligands-with-antipsychotic-like-mood-modulating-and-procognitive-activity
#6
Adam Bucki, Monika Marcinkowska, Joanna Śniecikowska, Krzysztof Więckowski, Maciej H Pawłowski, Monika Głuch-Lutwin, Anna Gryboś, Agata Siwek, Karolina Pytka, Magdalena Jastrzębska-Więsek, Anna Partyka, Anna Wesołowska, Paweł Mierzejewski, Marcin Kołaczkowski
The most troublesome aspects of behavioral and psychological symptoms of dementia (BPSD) are nowadays addressed by antidepressant, anxiolytic and antipsychotic drugs, often administered off-label. Considering their modest effectiveness in dementia patients, the increased risk of adverse events and cognitive decline, there is an unmet need for well-tolerated and effective therapy of BPSD. We designed and synthesized multifunctional ligands characterized in vitro as high-affinity partial agonists of D2R, antagonists of 5-HT6R and blockers of SERT...
August 1, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28754586/distress-associated-with-dementia-related-psychosis-and-agitation-in-relation-to-healthcare-utilization-and-costs
#7
Donovan T Maust, Helen C Kales, Ryan J McCammon, Frederic C Blow, Amanda Leggett, Kenneth M Langa
OBJECTIVES: Explore the relationship between behavioral and psychological symptoms of dementia (BPSD; specifically, delusions, hallucinations, and agitation/aggression) and associated caregiver distress with emergency department (ED) utilization, inpatient hospitalization, and expenditures for direct medical care. DESIGN/SETTING/PARTICIPANTS: Retrospective cross-sectional cohort of participants with dementia (N = 332) and informants from the Aging, Demographics, and Memory Study, a nationally representative survey of U...
May 25, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28754095/comparison-of-neuropsychiatric-symptoms-and-diffusion-tensor-imaging-correlates-among-patients-with-subcortical-ischemic-vascular-disease-and-alzheimer-s-disease
#8
Min-Chien Tu, Wen-Hui Huang, Yen-Hsuan Hsu, Chung-Ping Lo, Jie Fu Deng, Ching-Feng Huang
BACKGROUND: The causes of behavioral and psychological symptoms of dementia (BPSD) vary according to the dementia subtype and associated neuropathology. The present study aimed to (i) compare BPSD between patients with subcortical ischemic vascular disease (SIVD) and Alzheimer's disease (AD) across stages, and (ii) explore the associations with diffusion tensor imaging (DTI) in the corpus callosum (CC) and other major fibers. METHODS: Twenty-four patients with SIVD and 32 with AD were recruited...
July 28, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28754047/introducing-namaste-care-to-the-hospital-environment-a-pilot-study
#9
Kimberley St John, Jonathan Koffman
BACKGROUND: The rising prevalence of dementia is impacting on acute hospitals and placing increased expectations on health and social care professionals to improve the support and services they are delivering. It has been recommended that good practice in dementia care relies on adopting a palliative approach to care and meeting people's physical, psychological, social and spiritual needs. Increased dementia training for staff that includes initiatives that promote dignity; enhancing communication skills and recognizing that a person with dementia may be approaching the end of their lives are needed...
October 2017: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/28746708/effectiveness-and-safety-of-dementia-care-management-in-primary-care-a-randomized-clinical-trial
#10
Jochen René Thyrian, Johannes Hertel, Diana Wucherer, Tilly Eichler, Bernhard Michalowsky, Adina Dreier-Wolfgramm, Ina Zwingmann, Ingo Kilimann, Stefan Teipel, Wolfgang Hoffmann
Importance: Dementia care management (DCM) can increase the quality of care for people with dementia. Methodologically rigorous clinical trials on DCM are lacking. Objective: To test the effectiveness and safety of DCM in the treatment and care of people with dementia living at home and caregiver burden (when available). Design, Setting, and Participants: This pragmatic, general practitioner-based, cluster-randomized intervention trial compared the intervention with care as usual at baseline and at 12-month follow-up...
July 26, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28720243/strategies-to-engage-older-adults-with-behavioral-and-psychological-symptoms-of-dementia-in-exercise-a-multiple-case-study
#11
Fang Yu, Susan Greimel, Kaitlin Kelly, Jean F Wyman
No abstract text is available yet for this article.
August 2017: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/28705297/the-diagnosis-and-treatment-of-behavioral-disorders-in-dementia
#12
Torsten Kratz
BACKGROUND: Behavioral disorders such as aggressiveness, agitation, delusions, disinhibition, affect lability, and apathy arise in more than 90% of patients with dementia. Behavioral disorders are a major challenge and the greatest stress factor in everyday life for nursing personnel and for family members caring for the patient. METHODS: This review is based on relevant publications retrieved by a selective literature search in the PubMed, Cochrane Library, and German S3 guideline databases with the search terms "behavioral disorders," "non-cognitive disorders," and "challenging behavior," in conjunction with "dementia" and "behavioral and psychological symptoms of dementia...
June 30, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/28670272/behavioral-and-psychological-symptoms-impact-clinical-competence-in-alzheimer-s-disease
#13
Elodie Bertrand, Eelco van Duinkerken, J Landeira-Fernandez, Marcia C N Dourado, Raquel L Santos, Jerson Laks, Daniel C Mograbi
Decision-making is considered a fundamental aspect of personal autonomy and can be affected in psychiatric and neurologic diseases. It has been shown that cognitive deficits in dementia impact negatively on decision-making. Moreover, studies highlighted impaired clinical competence in neuropsychiatric disorders, such as schizophrenia and bipolar disorder. In this context, the current study explored the relationship between behavioral and psychological symptoms of dementia (BPSD) and clinical competence, especially the capacity to consent to treatment, in Alzheimer's disease (AD)...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28665099/improvement-in-behavioral-and-psychological-symptoms-of-dementia-by-rivastigmine-patch-in-a-group-of-italian-elderly-patients-with-alzheimer-s-disease
#14
Adriana Servello, Evaristo Ettorre, Mauro Cacciafesta
No abstract text is available yet for this article.
September 2017: Panminerva Medica
https://www.readbyqxmd.com/read/28662557/reducing-off-label-antipsychotic-use-in-older-community-dwelling-adults-with-dementia-a-narrative-review
#15
Kevin T Bain, Emily J Schwartz, Rengena Chan-Ting
The off-label use of antipsychotics for the management of behavioral and psychologic symptoms of dementia (BPSD) in older adults (age ≥65 years) is common, despite evidence of modest benefits and serious risks. Although national initiatives aimed at reducing antipsychotic use among older adults with BPSD in nursing homes have been successful, similar initiatives are lacking for community-dwelling adults with dementia. As a result, older adults with BPSD residing in the community may be at an even greater risk of being negatively affected by antipsychotic use...
July 1, 2017: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/28624505/deficiency-in-ep4-receptor-associated-protein-ameliorates-abnormal-anxiety-like-behavior-and-brain-inflammation-in-a-mouse-model-of-alzheimer-disease
#16
Risako Fujikawa, Sei Higuchi, Masato Nakatsuji, Mika Yasui, Taichi Ikedo, Manabu Nagata, Kosuke Hayashi, Masayuki Yokode, Manabu Minami
Microglia are thought to play key roles in the progression of Alzheimer disease (AD). Overactivated microglia produce proinflammatory cytokines, such as tumor necrosis factor-α, which appear to contribute to disease progression. Previously, we reported that prostaglandin E2 type 4 receptor-associated protein (EPRAP) promotes microglial activation. We crossed human amyloid precursor protein transgenic mice from strain J20(+/-) onto an EPRAP-deficient background to determine the role of EPRAP in AD. Behavioral tests were performed in 5-month-old male J20(+/-)EPRAP(+/+) and J20(+/-)EPRAP(-/-) mice...
June 15, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28554324/multi-target-directed-ligands-affecting-serotonergic-neurotransmission-for-alzheimer-s-disease-therapy-advances-in-chemical-and-biological-research
#17
Agnieszka Jankowska, Anna Wesołowska, Maciej Pawłowski, Grażyna Chłoń-Rzepa
Alzheimer's disease (AD) is an age-related neurodegenerative disorder characterized by a progressive cognitive impairments and chronic inflammation that affects over 30 million people all over the world. Most of Alzheimer's patients also suffer from psychosis, aggression, agitation, depression, anxiety, and many other behavioral and psychological symptoms of dementia. Unfortunately, currently available anti-AD drugs provide modest symptomatic relief, and do not reverse the neurodegeneration. Consequently, the average life expectancy after diagnosis is between six to ten years...
May 29, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28535075/variance-in-caregiver-burden-predicted-by-patient-behaviors-versus-neuropsychological-profile
#18
Camille Branger, Joe Enright, Megan E O'Connell, Debra G Morgan
Informal caregivers provide the majority of care to persons with dementia; efforts to support caregivers' well-being are increasingly important in the context of limited formal healthcare supports. Informal caregiving is commonly associated with caregiver burden and burden may depend upon patient characteristics including neuropsychological profile, dementia severity, and dementia etiology. This study investigated predictors of caregiver burden in a sample of 213 Memory Clinic patients diagnosed with dementia and whose caregivers provided collateral information...
May 23, 2017: Applied Neuropsychology. Adult
https://www.readbyqxmd.com/read/28521701/unexpected-effects-of-acetylcholine-precursors-on-pilocarpine-seizure-induced-neuronal-death
#19
Minwoo Lee, Bo Young Choi, Sang Won Suh
Choline alfoscerate (α-GPC) and Cytidine 5'-diphosphocholine (CDP-Choline) are both acetylcholine precursors and are considered to act as pro-cholinergic nootropic agents. Acetylcholine precursors have also recently found frequent use in the neurology clinic. Stroke and many types of dementia have been shown to respond favorably after treatment with these agents, not only in terms of cognitive dysfunction but also behavioral and psychological symptoms. The primary mechanisms of Acetylcholine precursors are the following: 1) Acetylcholine precursors themselves are used in the biosynthesis of acetylcholine and 2) byproducts like glycerophosphate have protective functions for neuronal phospholipids...
May 18, 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28521676/the-ultimate-outlier-transitional-care-for-persons-with-dementia-and-bpsd
#20
Jiska Cohen-Mansfield, Colleen A Ray, Tasmia Hai, Cristina Marcu, Brandy L Callahan, Morris Freedman
BACKGROUND: Transitional care units aim to assist caregivers who cannot manage the care for persons with dementia who manifest behavioral and psychological symptoms of dementia (BPSD). However, there is a dearth in research on such care units. OBJECTIVE: The current study reviewed one specialized transitional unit to better understand the characteristics of the persons with dementia and behavioral symptoms entering such unit. The study also looked at the change in terms of (a) BPSD, (b) use of psychotropic medications and (c) function of the patients in this unit...
May 15, 2017: Current Alzheimer Research
keyword
keyword
30318
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"