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https://www.readbyqxmd.com/read/29701380/renal-autotransplantation-the-solution-for-different-pathologies
#1
Pedro Pinto Sousa, Rui Machado, Pedro Sá Pinto, Rui Almeida
INTRODUCTION: Renal autotransplantation (RA) is a safe and effective procedure to reconstruct the urinary tract which first successful surgery was performed by Hardy in 1963. The main indications reported for performing RA generally includes renovascular disease, ureteral pathologies and neoplastic disease. RA may be also useful as the last recourse in preventing kidney loss in highly selected patients, especially when conventional methods have failed. METHODS: The authors pretend to describe four total different situations where the RA was the key solution for the pathology initially presented...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29701146/role-of-melatonin-in-the-inflammatory-process-and-its-therapeutic-potential
#2
Livia Carrascal, Pedro Nunez-Abades, Antonio Ayala, Mercedes Cano
Melatonin is an indolamine synthesized and secreted by the pineal gland along with other sources including immune system cells, the brain, skin and the gastrointestinal tract. Growing interest in this compound as a potential therapeutic agent in several diseases stems from its pleiotropic effects. Thus, melatonin plays a key role in various physiological activities that include regulation of circadian rhythms, immune responses, the oxidative process, apoptosis or mitochondrial homeostasis. Most of these processes are altered during inflammatory pathologies, among which neurodegenerative and bowel diseases stand out...
April 25, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29687787/drug-induced-thrombotic-microangiopathy-with-certolizumab-pegol
#3
Mehmet Baysal, Elif Gülsüm Ümit, Fatih Sarıtaş, Nil Su Kodal, Ahmet Muzaffer Demir
BACKGROUND: Certolizumab pegol is used to treat ankylosing spondylitis (AS), chron disease, psoriatic arthritis and rheumatoid arthritis. In contrast to other monoclonal antibodies such as infliximab and adalimumab, certolizumab does not contain an Fc fraction and hence, does not induce complement activation. In this case, we are presenting a case with thrombotic microangiopathy (TMA) due to certolizumab pegol, with a touch of pathophysiological approach to TMA. CASE REPORT: A-39-year-old man with AS of ten years presented with fatigue...
April 24, 2018: Balkan Medical Journal
https://www.readbyqxmd.com/read/29680885/spatial-distribution-of-uranium-and-basic-water-quality-parameter-in-the-capital-of-bihar-and-consequent-ingestion-dose
#4
Deepak Kumar, Anshuman Singh, Rishi Kumar Jha
Investigation of presence of Uranium (U) in groundwater/drinking water is an active are of research due to its chemical and radiological toxicity as well as long-term health effects. The current study had the objective of estimating U as a naturally occurring radioactive element in groundwater samples and assessment of ingestion dose, when groundwater is the source of drinking water. The random sampling method was chosen for the collection of samples based on population density. The estimation of U was done using LED fluorimeter...
April 21, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29624919/increased-cytokines-in-cystic-fibrosis-patients-upper-airways-during-a-new-p-aeruginosa-colonization
#5
Anke Jaudszus, Christin Arnold, Julia Hentschel, Kerstin Hünniger, Michael Baier, Jochen G Mainz
OBJECTIVES: Previously, we found linkages of inflammatory mediator levels in CF upper airways (UAW) sampled by nasal lavage (NL) to disease severity and to chronic pathogen colonization such as Pseudomonas aeruginosa (PsA). Here, we assess UAW cytokine dynamics in CF patients with a new PsA colonization. METHODS: We measured cytokines in 149 longitudinally obtained NL samples from 34 CF patients. Cytokine concentrations determined prior to, at the time of de novo PsA detection in either UAW or lower airways (LAW), and in a subsequent PsA free period in newly colonized patients (PsA-new/n = 7) were compared to levels of not- (PsA-free/n = 13) and chronically colonized patients (PsA-chron/n = 14)...
April 6, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29447074/social-cognition-in-the-course-of-psychosis-and-its-correlation-with-biomarkers-in-a-male-cohort
#6
Evangelos Ntouros, Evangelos Karanikas, Georgios Floros, Christina Andreou, Aikaterini Tsoura, Georgios Garyfallos, Vasilios P Bozikas
INTRODUCTION: Patients diagnosed with schizophrenia display deficits in Theory of Mind (ToM) and Emotion Perception (EP) even before the appearance of full-blown symptomatology. METHODS: We evaluated ToM and EP in a male cohort consisting of 25 First Episode Psychosis (FEP) and 16 relapsed schizophrenic patients (CHRON) compared to 12 subjects in Ultra-high Risk (UHR) and 23 healthy controls (CTR). Furthermore, we measured the levels of Cortisol, Insulin like Growth Factor (IGF-1), TNF-a, TNF-b and several interleukins as potential biomarkers...
March 2018: Cognitive Neuropsychiatry
https://www.readbyqxmd.com/read/29311714/aeromagnetic-anomalies-reveal-the-link-between-magmatism-and-tectonics-during-the-early-formation-of-the-canary-islands
#7
Isabel Blanco-Montenegro, Fuensanta G Montesinos, José Arnoso
The 3-D inverse modelling of a magnetic anomaly measured over the NW submarine edifice of the volcanic island of Gran Canaria revealed a large, reversely-magnetized, elongated structure following an ENE-WSW direction, which we interpreted as a sill-like magmatic intrusion emplaced during the submarine growth of this volcanic island, with a volume that could represent up to about 20% of the whole island. The elongated shape of this body suggests the existence of a major crustal fracture in the central part of the Canary Archipelago which would have favoured the rapid ascent and emplacement of magmas during a time span from 0...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29131992/cross-validation-of-the-personality-assessment-inventory-chronic-suicide-risk-index-s_chron-in-a-large-sample-of-offenders
#8
John F Edens, Kevin S Douglas
Recently, Sinclair et al. (2016) reported on the development of a new Personality Assessment Inventory (PAI) index designed to identify individuals with histories of multiple suicide attempts (Chronic Suicide Risk Index: S_Chron). We evaluated this new index in a sample of over 1000 criminal offenders who had been administered the PAI as part of a more extensive research project. The S_Chron meaningfully discriminated between those with multiple prior suicide attempts and those with 0-1 attempts, similar to what Sinclair et al...
January 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29042899/evidence-for-hypothalamus-pituitary-adrenal-axis-and-immune-alterations-at-prodrome-of-psychosis-in-males
#9
Evangelos Karanikas, Evangelos Ntouros, Dimitrios Oikonomou, Georgios Floros, Ioannis Griveas, Georgios Garyfallos
We aimed to investigate the inflammatory substrate in psychosis by evaluating both the Hypothalamus-Pituitary-Adrenal axis function and immune state at prodrome. This involved the recruitment of Ultra High Risk (UHR) of Psychosis subjects, Healthy Controls (HC) and patients with established Schizophrenia (CHRON). Serum cortisol at 3 different times throughout the day was measured. The Dexamethasone Suppression Test was performed plus 12 circulating cytokines were measured. The UHR subjects presented increased IL-4 levels compared with both the HC and CHRON patients...
September 2017: Psychiatry Investigation
https://www.readbyqxmd.com/read/28724037/impact-of-biological-therapy-on-body-composition-of-patients-with-chron-s-disease
#10
Julianne Campos Dos Santos, Carla Malaguti, Fernando de Azevedo Lucca, Andrea Lemos Cabalzar, Tarsila Campanha da Rocha Ribeiro, Pedro Duarte Gaburri, Liliana Andrade Chebli, Julio Maria Fonseca Chebli
Introduction: Protein-energy malnutrition in Crohn's disease (CD) has been reported in 20 to 92% of patients, and is associated with increased morbidity and mortality and higher costs for the health system. Anti-TNF drugs are a landmark in the clinical management, promoting prolonged remission in patients with CD. It is believed that the remission of this disease leads to nutritional recovery. The effect of biological therapy on body composition and nutritional status is unclear. Method: Prospective study of body assessment by bioelectrical impedance method in patients with moderate to severe CD undergoing treatment with infliximab...
May 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/28566525/supplementation-with-rrr-or-all-rac-%C3%AE-tocopherol-differentially-affects-the-%C3%AE-tocopherol-stereoisomer-profile-in-the-milk-and-plasma-of-lactating-women
#11
Shashank Gaur, Matthew J Kuchan, Chron-Si Lai, Soren K Jensen, Christina L Sherry
Background: The naturally occurring α-tocopherol stereoisomer RRR- α-tocopherol is known to be more bioactive than synthetic α-tocopherol ( all-rac -α-tocopherol). However, the influence of this difference on the α-tocopherol stereoisomer profile of human milk is not understood. Objective: We investigated whether supplemental RRR- α-tocopherol or all-rac -α-tocopherol differentially affected the distribution of α-tocopherol stereoisomers in milk and plasma from lactating women. Methods: Eighty-nine lactating women aged 19-40 y and with a body mass index (in kg/m2 ) ≤30 were randomly assigned at 4-6 wk postpartum to receive a daily supplement containing 45...
July 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28544188/novel-tool-for-deprescribing-in-chronic-patients-with-multimorbidity-list-of-evidence-based-deprescribing-for-chronic-patients-criteria
#12
Aitana Rodríguez-Pérez, Eva Rocío Alfaro-Lara, Sandra Albiñana-Perez, María Dolores Nieto-Martín, Jesús Díez-Manglano, Concepción Pérez-Guerrero, Bernardo Santos-Ramos
AIM: To create a tool to identify drugs and clinical situations that offers an opportunity of deprescribing in patients with multimorbidity. METHODS: A literature review completed with electronic brainstorming, and subsequently, a panel of experts using the Delphi methodology were applied. The experts assessed the criteria identified in the literature and brainstorming as possible situations for deprescribing. They were also asked to assess the influence of life prognosis in each criterion...
November 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28525708/affinity-based-assembly-of-peptides-on-plasmonic-nanoparticles-delivered-intracellularly-with-light-activated-control
#13
Demosthenes P Morales, William R Wonderly, Xiao Huang, Meghan McAdams, Amanda B Chron, Norbert O Reich
We report a universal strategy for functionalizing near-infrared light-responsive nanocarriers with both a peptide "cargo" and an orthogonal cell-penetrating peptide. Modularity of both the cargo and the internalization peptide attachment is an important feature of these materials relying on the robust affinity of polyhistidine tags to nitrilotriacetic acid in the presence of nickel as well as the affinity of biotin labeled peptides to streptavidin. Attachment to the gold surface uses thiol-labeled scaffolds terminated with the affinity partner...
July 19, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28434540/an-updated-age-for-the-xujiayao-hominin-from-the-nihewan-basin-north-china-implications-for-middle-pleistocene-human-evolution-in-east-asia
#14
Hong Ao, Chun-Ru Liu, Andrew P Roberts, Peng Zhang, Xinwen Xu
The Xujiayao site in the Nihewan Basin (North China) is one of the most important Paleolithic sites in East Asia. Twenty Homo fossils, which were previously assigned to an archaic Homo sapiens group, have been excavated along with more than 30,000 lithic artifacts and ∼5000 mammalian fossil specimens. Dating of the Xujiayao hominin has been pursued since its excavation in the 1970s, but its age has remained controversial because of limitations of the dating techniques that have been applied to available materials...
May 2017: Journal of Human Evolution
https://www.readbyqxmd.com/read/28163989/authigenic-10-be-9-be-ratio-signatures-of-the-cosmogenic-nuclide-production-linked-to-geomagnetic-dipole-moment-variation-since-the-brunhes-matuyama-boundary
#15
Quentin Simon, Nicolas Thouveny, Didier L Bourlès, Jean-Pierre Valet, Franck Bassinot, Lucie Ménabréaz, Valéry Guillou, Sandrine Choy, Luc Beaufort
Geomagnetic dipole moment variations associated with polarity reversals and excursions are expressed by large changes of the cosmogenic nuclide beryllium-10 ((10)Be) production rates. Authigenic (10)Be/(9)Be ratios (proxy of atmospheric (10)Be production) from oceanic cores therefore complete the classical information derived from relative paleointensity (RPI) records. This study presents new authigenic (10)Be/(9)Be ratio results obtained from cores MD05-2920 and MD05-2930 collected in the west equatorial Pacific Ocean...
November 2016: Journal of Geophysical Research. Solid Earth
https://www.readbyqxmd.com/read/28151460/advancing-nursing-practice-the-emergence-of-the-role-of-advanced-practice-nurse-in-saudi-arabia
#16
Denise Hibbert, Ahmad E Aboshaiqah, Kathy A Sienko, Debra Forestell, Adel W Harb, Shadia A Yousuf, Patricia W Kelley, Patricia F Brennan, Laura Serrant, Alison Leary
BACKGROUND: The roots of advanced practice nursing (APN) can be traced back to the 1890s, but the nurse practitioner (NP) emerged in Western countries during the 1960s in response to the unmet healthcare needs of populations in rural areas. These early NPs utilized the medical model of care to assess, diagnose and treat. Nursing has since grown as a profession, with its own unique and distinguishable, holistic, science-based knowledge, which is complementary within the multidisciplinary team...
January 2017: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/27672632/comparison-of-brain-development-in-sow-reared-and-artificially-reared-piglets
#17
Reeba M Jacob, Austin T Mudd, Lindsey S Alexander, Chron-Si Lai, Ryan N Dilger
INTRODUCTION: Provision of adequate nutrients is critical for proper growth and development of the neonate, yet the impact of breastfeeding versus formula feeding on neural maturation has to be fully determined. Using the piglet as a model for the human infant, our objective was to compare neurodevelopment of piglets that were either sow-reared (SR) or artificially reared (AR) in an artificial setting. METHODS: Over a 25-day feeding study, piglets (1.5 ± 0...
2016: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/27620327/evaluating-chronic-suicide-risk-with-the-personality-assessment-inventory-development-and-initial-validation-of-the-chronic-suicide-risk-index-s_chron
#18
Samuel Justin Sinclair, Michael J Roche, Christina Temes, Christina Massey, Wei-Jean Chung, Michelle Stein, Laura Richardson, Mark Blais
The current study sought to develop and validate a new measure of chronic suicide risk (the S_Chron) from the Personality Assessment Inventory in a mixed sample of psychiatric inpatients and outpatients. In an initial development sample (N=397), hierarchical logistic regression identified six PAI variables uniquely associated with multiple versus single/no prior suicide attempts after controlling for sample demographics: Negative Impression Management, Situational Stress, Mania - Grandiosity, Borderline - Negative Relationships, Borderline - Self-Harm, and Antisocial Behaviors...
November 30, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27572303/geomagnetic-reversal-rates-following-palaeozoic-superchrons-have-a-fast-restart-mechanism
#19
Mark W Hounslow
Long intervals of single geomagnetic polarity (superchrons) reflect geodynamo processes, driven by core-mantle boundary interactions; however, it is not clear what initiates the start and end of superchrons, other than superchrons probably reflect lower heat flow across the core-mantle boundary compared with adjacent intervals. Here geomagnetic polarity timescales, with confidence intervals, are constructed before and following the reverse polarity Kiaman (Carboniferous-Permian) and Moyero (Ordovician) superchrons, providing a window into the geodynamo processes...
August 30, 2016: Nature Communications
https://www.readbyqxmd.com/read/27088019/adalimumab-another-medication-related-to-osteonecrosis-of-the-jaws
#20
Andrea Cassoni, Umberto Romeo, Valentina Terenzi, Marco Della Monaca, Oriana Rajabtork Zadeh, Ingrid Raponi, Maria Teresa Fadda, Antonella Polimeni, Valentino Valentini
Objective. The acronym MRONJ has been created in order to identify "Medication-Related Osteonecrosis of the Jaw," observed after the use of Bisphosphonates, RANK ligand inhibitor, and antiangiogenic medications. Only a case of osteonecrosis of the jaw in a Chron's disease patient following a course of Bisphosphonate and Adalimumab therapy has been recently described, so that it has been supposed that also this medication could promote manifestation of osteonecrosis. Clinical Case. On August, 2014, a 63-year-old female with a history of idiopathic arthritis treated with medical treatment with Adalimumab from 2010 to 2013 presented referring pain in the right mandible...
2016: Case Reports in Dentistry
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