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https://www.readbyqxmd.com/read/29793174/effect-of-ca-2-ion-concentration-on-adsorption-of-poly-carboxylate-ether-based-pce-superplasticizer-on-mica
#1
Bo Wu, Byong-Wa Chun, Le Gu, Tonya L Kuhl
HYPOTHESIS: Poly(carboxylate ether)-based (PCE) superplasticizers consist of a carboxylic acid backbone and grafted poly(ethylene glycol) (PEG) side chains. Ca2+ ion bridging mechanism is commonly purported to control PCE's adsorption on negatively charged cement particle surfaces in cement suspension, thus PCE was expected to adsorb on negatively charged surfaces in synthetic pore solutions via Ca2+ /COO- interactions. EXPERIMENTS: Adsorption behaviors of a commercial PCE on negatively charged mica were studied in aqueous electrolyte solutions by a surface forces apparatus...
May 9, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29793091/effects-of-surface-modification-of-as-2-o-3-loaded-plga-nanoparticles-on-its-anti-liver-cancer-ability-an-in-vitro-and-in-vivo-study
#2
Xiaoli Song, Juan You, Hongxia Shao, Caifeng Yan
As2 O3 -loaded nanoparticles (NPs) based on poly (lactic-co-glycolic acid) (PLGA) were prepared by double emulsion-solvent evaporation method. Then Lactose acid (LA) and/or PEG were modified onto the NPs by chemical covalent coupling through -NH2 and -COOH. The FTIR results showed that LA and PEG could be successfully modified onto the surface of the NPs. All the As2 O3 -loaded PLGA NPs (As2 O3 @PLGA NPs) presented suitable physical stability, favorable size, and spherical shape. The in vitro release rate of As2 O3 from the NPs depended on the surface of the NPs...
May 21, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29792279/can-intraoperative-measurement-of-bone-quality-help-in-decision-making-for-cementless-unicompartmental-knee-arthroplasty
#3
Johannes A Eckert, Sebastian Jaeger, Matthias C Klotz, Martin Schwarze, Rudi G Bitsch
BACKGROUND: In uncemented total hip arthroplasty (THA), low bone mineral density (BMD) is associated with aseptic loosening. BMD is usually assessed via dual-energy X-ray absorptiometry (DXA) or quantitative computed tomography, which takes time and exposes patients to radiation. Due to its low risk profile, intraoperative measurement of the trabecular stability might be a useful alternative to DXA. METHODS: In 24 human femora, BMD was analysed using DXA at the femoral necks and the knees...
May 20, 2018: Knee
https://www.readbyqxmd.com/read/29791802/the-power-of-shielding-low-toxicity-and-high-transfection-performance-of-cationic-graft-copolymers-containing-poly-2-oxazoline-side-chains
#4
Anne-Kristin Trützschler, Tanja Bus, Martin Sahn, Anja Traeger, Christine Weber, Ulrich S Schubert
In this study we show the potential of oligo(2-ethyl-2-oxazoline) (OEtOx) shielded graft copolymers of (2 aminoethyl)-methacrylate (AEMA) and N methyl (2-aminoethyl) methacrylate (MAEMA) for pDNA delivery in HEK cells. Copolymers were synthesized via the macromonomer method using a combination of cationic ring opening polymerization (CROP) and reversible addition-fragmentation chain transfer (RAFT) polymerization to vary the degree of grafting (DG = 10% and 30%) as well as the side chain degree of polymerization (DP = 5 and 20)...
May 23, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29791282/quantitation-of-plasmacytoid-dendritic-cells-in-chronic-hepatitis-b-patients-with-hbeag-positivity-during-peg-ifn-and-entecavir-therapy
#5
Wei-Hua Cao, Ming-Hui Li, Calvin Q Pan, Yao Lu, Lu Zhang, Chong-Ping Ran, Shu-Ling Wu, Wen-Hao Hua, Shun-Ai Liu, Ge Shen, Min Chang, Ru-Yu Liu, Hong-Xiao Hao, Lei-Ping Hu, Yao Xie
Plasmacytoid dendritic cells (pDCs) are crucial for control of chronic hepatitis B (CHB) virus infection. In this study, we evaluated the frequencies of pDCs and expression of functional molecules on pDCs in patients treated with PEG-IFN-α-2a or entecavir (ETV) and investigated changes during treatment. The mean fluorescence intensity of CD86 (CD86MFI) on the surface of pDCs and frequencies of pDCs and CD86+ pDCs in peripheral blood were measured. Compared with baseline, CD86+ pDC% and CD86MFI increased obviously after PEG-IFN-α-2a treatment for 12 and 24 weeks...
May 2018: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/29791137/the-chemistry-of-lyophilized-blood-products
#6
Joseph Fernandez-Moure, Nuzhat Maisha, Erin B Lavik, Jeremy Cannon
With the development of new biologics and bioconjugates, storage and preservation have become more critical than ever before. Lyophilization is a method of cell and protein preservation by removing a solvent such as water from a substance followed by freezing. This technique has been used in the past and still holds promise for overcoming logistic challenges in safety net hospitals with limited blood banking resources, austere environments such as combat, and in mass casualty situations where existing resources may be outstripped...
May 23, 2018: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29790879/exploring-matrix-effects-and-quantifying-organic-additives-in-hydraulic-fracturing-associated-fluids-using-liquid-chromatography-electrospray-ionization-mass-spectrometry
#7
Marika Nell, Damian E Helbling
Hydraulic fracturing (HF) operations utilize millions of gallons of water amended with chemical additives including biocides, corrosion inhibitors, and surfactants. Fluids injected into the subsurface return to the surface as wastewaters, which contain a complex mixture of additives, transformation products, and geogenic chemical constituents. Quantitative analytical methods are needed to evaluate wastewater disposal alternatives or to conduct adequate exposure assessments. However, our narrow understanding of how matrix effects change the ionization efficiency of target analytes limits the quantitative analysis of polar to semi-polar HF additives by means of liquid chromatography electrospray ionization mass spectrometry (LC-ESI-MS)...
May 23, 2018: Environmental Science. Processes & Impacts
https://www.readbyqxmd.com/read/29790803/ultrasound-guided-delivery-of-thymidine-kinase-nitroreductase-dual-therapeutic-genes-by-pegylated-plga-pie-nanoparticles-for-enhanced-triple-negative-breast-cancer-therapy
#8
Rammohan Devulapally, Taehwa Lee, Aarohi Barghava-Shah, Thillai V Sekar, Kira Foygel, Sunitha V Bachawal, Jürgen K Willmann, Ramasamy Paulmurugan
AIM: Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype. Since no targeted therapy is available, gene-directed enzyme prodrug therapy (GDEPT) could be an attractive strategy for treating TNBC. MATERIALS & METHODS:  Polyethylene glycol (PEG)ylated-poly(lactic-co-glycolic acid)/polyethyleneimine nanoparticles (PLGA/PEI NPs) were synthesized and complexed with TK-NTR fusion gene. Ultrasound (US) and microbubble (MB) mediated sonoporation was used for efficient delivery of the TK-NTR-DNA-NP complex to TNBC tumor in vivo for cancer therapy...
May 2018: Nanomedicine
https://www.readbyqxmd.com/read/29790795/octa-arginine-modified-poly-amidoamine-dendrimers-for-improved-delivery-and-cytotoxic-effect-of-paclitaxel-in-cancer
#9
Sri Vishnu Kiran Rompicharla, Preeti Kumari, Balaram Ghosh, Swati Biswas
Cell penetrating peptides (CPP) have the ability to penetrate the cell membrane and have been associated with various cargos for their facile intracellular translocation. The current study involves the synthesis of a CPP, octa-arginine (R8)-modified poly(amidoamine) dendrimer of generation 4 (G4), which has additionally been PEGylated and conjugated to the poorly soluble anticancer drug, paclitaxel (PTX). The synthesized dendrimer conjugates were characterized by proton nuclear magnetic resonance (1H-NMR) Spectroscopy and zeta potential measurements and evaluated in vitro in cell monolayers and 3D spheroids...
May 23, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29790278/the-split-dose-4-l-polyethylene-glycol-regimen-for-patients-with-previous-colorectal-surgery-in-bowel-preparation-before-colonoscopy-a-randomized-controlled-single-blind-study
#10
Zhu Liu, Yue-Yue Li, Xue-Ting Luo, Chuan-Guo Guo, Ming-Ming Zhang, Zhen Li, Li-Xiang Li, Yan Zhang, Yan-Qing Li
AIM: In some Asian countries, guidelines recommend 2-L polyethylene glycol (PEG) without any additions as the standard bowel preparation (BP) regimen before colonoscopy, which is not sufficient for patients with previous colorectal surgery. The objective of this study was to investigate the efficacy of the split-dose 4-L PEG regimen on the quality of BP in Asian patients with previous colorectal surgery. METHODS: This was a single-center, prospective, randomized-controlled, endoscopist-blinded study...
May 22, 2018: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/29790012/evaluation-of-a-nanocomposite-of-peg-curcumin-gold-nanoparticles-as-a-near-infrared-photothermal-agent-an-in-vitro-and-animal-model-investigation
#11
F Rahimi-Moghaddam, N Azarpira, N Sattarahmady
Hyperthermia is a promising alternative modality for the conventional cancer treatments. Nanoparticle-mediated photothermal therapy (PTT) has been widely applied for hyperthermia cancer therapy by a near-infrared light irradiation. Some special nanoparticles can convert light energy into heat and destroy the tumor cells. Inspired from the photothermal efficacy of the gold nanoparticles, here we synthesized, characterized, and applied novel photothermal polyethylene glycol-curcumin-gold nanoparticles (PEG-Cur-Au NPs) in cancer PTT...
May 22, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29789104/functionalized-caprolactone-polyethylene-glycol-based-thermo-responsive-hydrogels-of-silibinin-for-the-treatment-of-malignant-melanoma
#12
Behzad Sharif Makhmalzadeh, Ommoleila Molavi, Mohammad Reza Vakili, Hai-Feng Zhang, Amir Solimani, Hoda Soleymani Abyaneh, Raimar Loebenberg, Raymond Lai, Afsaneh Lavasanifar
PURPOSE: Silibinin, is a natural compound, which has shown anticancer activity in various malignancies. In this study, we evaluated the anticancer effects of silibinin in B16-F10 melanoma cells and developed a novel thermoresponsive hydrogel for local delivery of this compound. METHOD: A thermoresponsive hydrogel loaded with silibinin was prepared using triblock copolymers of poly[(α-benzyl carboxylate-e-caprolactone)-co-(α-carboxyl-e-caprolactone)]ran-b-PEG-b-[(α-benzyl carboxylate-e-caprolactone) -co-(α-carboxyl-e-caprolactone)]ran (PCBCL-b-PEG-b-PCBCL), namely PolyGelTM, and compared with a Pluronic F-127 formulation of silibinin...
2018: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29788718/morphology-and-physical-properties-of-hydrophilic-polymer-modified-lipids-in-supported-lipid-bilayers
#13
Yasuhiro Kakimoto, Yoshihiro Tachihara, Yoshiaki Okamoto, Keisuke Miyazawa, Takeshi Fukuma, Ryugo Tero
Lipid molecules such as glycolipids which are modified with hydrophilic biopolymers participate in the biochemical reactions occurring on cell membranes. Their functions and efficiency are determined by the formation of microdomains and their physical properties. We investigated the morphology and properties of domains induced by the hydrophilic-polymer-modified lipid applying poly-ethylene glycol (PEG)-modified lipid as a model modified lipid. We formed supported lipid bilayers (SLBs) using a 0-10 mol % range of PEG-modified lipid concentration (CPEG)...
May 23, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29788161/new-reagents-for-poultry-research-preparation-purification-and-in-vitro-evaluation-of-non-pegylated-and-mono-pegylated-chicken-prolactin
#14
Ewa Oclon, Gili Solomon, Anna Hrabia, Shelly Druyan, Zvi Hayouka, Arieh Gertler
Recombinant chicken prolactin (chPRL), expressed in Escherichia coli and purified as a monomer, was successfully PEGylated and purified to homogeneity as a mono-PEGylated protein (PEG-chPRL). Its biological activity was estimated by its ability to interact with human prolactin receptor extracellular domain (hPRLR-ECD) and stimulate PRLR-mediated proliferation in Nb2-11C cells. PEG-chPRL activity in a cell bioassay was 10-fold lower than that of non-PEGylated chPRL, but only 2-fold lower in a binding assay to hPRLR-ECD...
May 18, 2018: Poultry Science
https://www.readbyqxmd.com/read/29787231/glucose-and-h2o2-responsive-polymeric-vesicles-integrated-with-microneedle-patches-for-glucose-sensitive-transcutaneous-delivery-of-insulin-in-diabetic-rats
#15
Zaizai Tong, Junyi Zhou, Jiaxing Zhong, Qiuju Tang, Zhentao Lei, Haipeng Luo, Pianpian Ma, XiangDong Liu
Herein, a dual-responsive insulin delivery device by integrating glucose- and H2O2-responsive polymeric vesicles (PVs) with transcutaneous microneedles (MNs) has been designed. This novel microneedle delivery device achieves a goal of a fast response, excellent biocompatibility and painless administration. The PVs are self-assembled from a triblock copolymer involving with polyethylene glycol (PEG), poly(phenylboronic acid) (PPBA, glucose-sensitive block) and poly(phenylboronic acid pinacol ester) (PPBEM, H2O2-sensitive block)...
May 22, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29786467/bombesin-functionalized-64-cu-copper-sulfide-nanoparticles-for-targeted-imaging-of-orthotopic-prostate-cancer
#16
Huawei Cai, Fang Xie, Aditi Mulgaonkar, Lihong Chen, Xiankai Sun, Jer-Tsong Hsieh, Fangyu Peng, Rong Tian, Lin Li, Changqiang Wu, Hua Ai
AIM: To synthesize and evaluate the imaging potential of Bom-PEG-[64 Cu]CuS nanoparticles (NPs) in orothotopic prostate tumor. MATERIALS & METHODS: [64 Cu]CuS NPs were synthesized in aqueous solution by 64 CuCl2 and Na2 S reaction. Then PEG linker with or without bombesin peptide were conjugated to the surface of [64 Cu]CuS NPs to produce Bom-PEG-[64 Cu]CuS and PEG-[64 Cu]CuS NPs. These two kinds of NPs were used for testing specific uptake in prostate cancer cells in vitro and imaging of orthotopic prostate tumor in vivo...
May 22, 2018: Nanomedicine
https://www.readbyqxmd.com/read/29786101/a-peg-copper-i-halide-cluster-as-an-eco-friendly-catalytic-system-for-c-n-bond-formation
#17
Cheng-An Li, Wei Ji, Jian Qu, Su Jing, Fei Gao, Dun-Ru Zhu
The catalytic activities of eight copper(i) halide clusters assembled from copper(i) halide and ferrocenyltelluroethers, 1-8, were investigated in C-N formation under various conditions. A catalytic procedure using poly(ethylene glycol) (PEG-400) as a greener alternative organic solvent has been developed. The PEG-400/5 system can achieve 99% targeted yield with a mild reaction temperature and short reaction time. After the isolation of the products by extraction with diethyl ether, this PEG-400/cluster system could be easily recycled...
May 22, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29785745/use-of-proton-pump-inhibitors-is-associated-with-increased-mortality-due-to-nosocomial-pneumonia-in-bedridden-patients-receiving-tube-feeding
#18
Kosuke Hamai, Hiroshi Iwamoto, Shinichiro Ohshimo, Yu Wakabayashi, Daisuke Ihara, Kazunori Fujitaka, Hironobu Hamada, Koichi Ono, Noboru Hattori
AIM: To investigate the association between the use of proton pump inhibitors (PPI) and nosocomial pneumonia and gastrointestinal bleeding in bedridden patients receiving tube feeding. METHODS: A total of 116 bedridden hospitalized patients receiving tube feeding, of which 80 were supported by percutaneous endoscopic gastrostomy and 36 by nasogastric tube, were included in the present study. The patients were divided into two groups: 62 patients treated with PPI (PPI group) and 54 patients without PPI (non-PPI group)...
May 22, 2018: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/29785485/peg-manipulation-capabilities-of-middle-aged-adults-have-a-greater-influence-on-pegboard-times-than-those-of-young-and-old-adults
#19
Awad M Almuklass, Daniel F Feeney, Diba Mani, Landon D Hamilton, Roger M Enoka
Declines in manual dexterity are frequently quantified as the time it takes to complete the grooved pegboard test. The test requires individuals to manipulate 25 pegs, one at a time, by removing them from a well and inserting them into a prescribed hole. The manipulation of each peg involves four phases: selection, transport, insertion, and return. The purpose of our study was to compare the times to complete the four phases of peg manipulation and the forces applied to the pegboard during peg insertion as young, middle-aged, and old adults performed the grooved pegboard test...
May 22, 2018: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/29785179/nanoformulation-of-brain-derived-neurotrophic-factor-with-target-receptor-triggered-release-in-the-central-nervous-system
#20
Yuhang Jiang, James M Fay, Chi-Duen Poon, Natasha Vinod, Yuling Zhao, Kristin Bullock, Si Qin, Devika S Manickam, Xiang Yi, William A Banks, Alexander V Kabanov
Brain-derived neurotrophic factor (BDNF) is identified as a potent neuroprotective and neuroregenerative agent for many neurological diseases. Regrettably, its delivery to the brain is hampered by poor serum stability and rapid brain clearance. Here, a novel nanoformulation is reported composed of a bio-compatible polymer, poly(ethylene glycol)- b -poly(L-glutamic acid) (PEG-PLE), that hosts the BDNF molecule in a nanoscale complex, termed here Nano-BDNF. Upon simple mixture, Nano-BDNF spontaneously forms uniform spherical particles with a core-shell structure...
February 7, 2018: Advanced Functional Materials
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