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https://www.readbyqxmd.com/read/28934372/antibacterial-effects-of-the-artificial-surface-of-nanoimprinted-moth-eye-film
#1
Kiyoshi Minoura, Miho Yamada, Takashi Mizoguchi, Toshihiro Kaneko, Kyoko Nishiyama, Mari Ozminskyj, Tetsuo Koshizuka, Ikuo Wada, Tatsuo Suzutani
The antibacterial effect of a nanostructured film, known as "moth-eye film," was investigated. The moth-eye film has artificially formed nano-pillars, consisting of hydrophilic resin with urethane acrylate and polyethylene glycol (PEG) derivatives, all over its surface that replicates a moth's eye. Experiments were performed to compare the moth-eye film with a flat-surfaced film produced from the same materials. The JIS Z2801 film-covering method revealed that the two films produced a decrease in Staphylococcus aureus and Esherichia coli titers of over 5 and 3 logs, respectively...
2017: PloS One
https://www.readbyqxmd.com/read/28933351/dosimetric-effects-of-polyethylene-glycol-surface-coatings-on-gold-nanoparticle-radiosensitization
#2
Brandon Koger, Charles Kirkby
One of the main appeals of using gold nanoparticles (GNPs) as radiosensitizers is that their surface coatings can be altered to manipulate their pharmacokinetic properties. However, Monte Carlo studies of GNP dosimetry tend to neglect these coatings, potentially changing the dosimetric results. This study quantifies the dosimetric effects of including a polyethylene glycol (PEG) surface coating on GNPs over both nanoscopic and microscopic ranges. Two dosimetric scales were explored using PENELOPE Monte Carlo simulations...
September 21, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28932984/rnai-mediated-down-regulation-of-a-melanin-polyketide-synthase-pks1-gene-in-the-fungus-slafractonia-leguminicola
#3
Mohammad S Alhawatema, Sayed Gebril, Daniel Cook, Rebecca Creamer
The fungus Slafractonia leguminicola, the causal agent of blackpatch disease of legumes produces two mycotoxins slaframine and swainsonine, causing slobbers' symptoms and locoism of grazing animals, respectively. The genetics of this important fungus is poorly understood. This work aimed to develop a genetic transformation system and evaluate the efficacy of RNA interference (RNAi) in S. leguminicola. In this study, S. leguminicola was transformed using a PEG-mediated method with a fungal construct that carries a hygromycin resistance cassette...
September 20, 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28932978/biobutanol-production-from-apple-pomace-the-importance-of-pretreatment-methods-on-the-fermentability-of-lignocellulosic-agro-food-wastes
#4
María Hijosa-Valsero, Ana I Paniagua-García, Rebeca Díez-Antolínez
Apple pomace was studied as a possible raw material for biobutanol production. Five different soft physicochemical pretreatments (autohydrolysis, acids, alkalis, organic solvents and surfactants) were compared in a high-pressure reactor, whose working parameters (temperature, time and reagent concentration) were optimised to maximise the amount of simple sugars released and to minimise inhibitor generation. The pretreated biomass was subsequently subjected to a conventional enzymatic treatment to complete the hydrolysis...
September 20, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28932820/reduced-arterial-elasticity-due-to-surgical-skeletonization-is-ameliorated-by-abluminal-peg-hydrogel
#5
Karyn G Robinson, Rebecca A Scott, Anne M Hesek, Edward J Woodford, Wafa Amir, Thomas A Planchon, Kristi L Kiick, Robert E Akins
Arteries for bypass grafting are harvested either with neighboring tissue attached or as skeletonized vessels that are free of surrounding tissue. There are significant benefits to skeletonization, but reports suggest that skeletonized vessels may develop structural defects and are at risk for atherosclerosis. We investigated the specific short-term effects of skeletonization on carotid artery biomechanics and microanatomy in a rabbit model. Six carotid arteries were surgically skeletonized. To support healing, three of these received polyethylene glycol hydrogel injected along their exterior surfaces...
June 2017: Bioengineering & Translational Medicine
https://www.readbyqxmd.com/read/28932117/multifunctional-folate-receptor-targeting-and-ph-responsive-nanocarriers-loaded-with-methotrexate-for-treatment-of-rheumatoid-arthritis
#6
Jinlong Zhao, Menghui Zhao, Changhui Yu, Xueyan Zhang, Jiaxin Liu, Xinwei Cheng, Robert J Lee, Fengying Sun, Lesheng Teng, Youxin Li
Rheumatoid arthritis (RA) is an autoimmune disease characterized by progressive cartilage and bone destruction. Activated macrophages that overexpress folic acid (FA) receptors play an important role in RA, due to their abundance in inflamed synovial membrane and joints. In an effort to deliver drugs to the inflamed tissues, multifunctional FA receptor-targeting and pH-responsive nanocarriers were developed. They were composed of lipids, polyethylene glycol (PEG)-poly(lactic-co-glycolic acid) (PLGA) forming a hydrophilic shell, FA around the hydrophilic shell as a targeting ligand, and poly(cyclohexane-1,4-diylacetone dimethylene ketal) (PCADK) and PLGA as a hydrophobic core...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28932114/spermidine-mediated-poly-lactic-co-glycolic-acid-nanoparticles-containing-fluorofenidone-for-the-treatment-of-idiopathic-pulmonary-fibrosis
#7
Jing Tang, Jianming Li, Guo Li, Haitao Zhang, Ling Wang, Dai Li, Jinsong Ding
Idiopathic pulmonary fibrosis is a progressive, fatal lung disease with poor survival. The advances made in deciphering this disease have led to the approval of different antifibrotic molecules, such as pirfenidone and nintedanib. An increasing number of studies with particles (liposomes, nanoparticles [NPs], microspheres, nanopolymersomes, and nanoliposomes) modified with different functional groups have demonstrated improvement in lung-targeted drug delivery. In the present study, we prepared, characterized, and evaluated spermidine (Spd)-modified poly(lactic-co-glycolic acid) (PLGA) NPs as carriers for fluorofenidone (AKF) to improve the antifibrotic efficacy of this drug in the lung...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28932092/systematic-review-and-meta-analysis-of-colon-cleansing-preparations-in-patients-with-inflammatory-bowel-disease
#8
Sophie Restellini, Omar Kherad, Talat Bessissow, Charles Ménard, Myriam Martel, Maryam Taheri Tanjani, Peter L Lakatos, Alan N Barkun
AIM: To performed a systematic review and meta-analysis to determine any possible differences in terms of effectiveness, safety and tolerability between existing colon-cleansing products in patients with inflammatory bowel disease. METHODS: Systematic searches were performed (January 1980-September 2016) using MEDLINE, EMBASE, Scopus, CENTRAL and ISI Web of knowledge for randomized trials assessing preparations with or without adjuvants, given in split and non-split dosing, and in high (> 3 L) or low-volume (2 L or less) regimens...
August 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28930649/ph-multistage-responsive-micellar-system-with-charge-switch-and-peg-layer-detachment-for-co-delivery-of-paclitaxel-and-curcumin-to-synergistically-eliminate-breast-cancer-stem-cells
#9
Zhe Yang, Na Sun, Rui Cheng, Chenyang Zhao, Zerong Liu, Xian Li, Jie Liu, Zhongmin Tian
Several studies have demonstrated that cancer stem cells (CSCs) are responsible for replenishing bulk tumor cells, generating new tumors and causing metastasis and relapse. Although combination therapy with multiple chemotherapeutics is considered to be a promising approach for simultaneously eliminating non-CSCs and CSCs, it is difficult to deliver drugs into the inner region of a solid tumor where the CSCs are located due to a lack of capillaries. Here, we synthesized a pH-sensitive polymer, poly(ethylene glycol)-benzoic imine-poly(γ-benzyl-l-aspartate)-b-poly(1-vinylimidazole) block copolymer (PPBV), to develop a pH multistage responsive micellar system for co-delivering paclitaxel and curcumin and synergistically eliminating breast cancer stem cells (bCSCs) and non-bCSCs...
September 10, 2017: Biomaterials
https://www.readbyqxmd.com/read/28930443/hydrogel-tethering-enhances-interdomain-stabilization-of-single-chain-antibodies
#10
Yijia Xiong, Nicole R Ford, Karen A Hecht, Guritno Roesijadi, Thomas C Squier
Here we identify the importance of molecular crowding agents in the functional stabilization of scFv antibodies. Antibodies were tethered through an engineered calmodulin (CaM) binding peptide into a stimulus-responsive hydrogel composed of poly-(ethylene glycol) (PEG) functionalized CaM. Macromolecular crowding is modulated by transient heating, which acts to decrease effective pore sizes. Using a fluorescent ligand bound to the scFv, frequency-domain fluorescence spectroscopy was used to assess the structural coupling between the VH and VL domains and relationships with functional stabilization...
September 20, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28930428/ion-transport-in-confined-geometries-below-the-nanoscale-access-resistance-dominates-protein-channel-conductance-in-diluted-solutions
#11
Antonio Alcaraz, M Lidón López, María Queralt-Martín, Vicente M Aguilella
Synthetic nanopores and mesoscopic protein channels have common traits like the importance of electrostatic interactions between the permeating ions and the nanochannel. Ion transport at the nanoscale occurs under confinement conditions so that the usual assumptions made in microfluidics are challenged, among others, by interfacial effects such as access resistance (AR). Here we show that a sound interpretation of electrophysiological measurements in terms of channel ion selective properties requires the consideration of interfacial effects, up to the point that they dominate protein channel conductance in diluted solutions...
September 20, 2017: ACS Nano
https://www.readbyqxmd.com/read/28930358/fabrication-and-characterization-of-a-3d-bioprinted-nanoparticle-hydrogel-hybrid-device-for-biomimetic-detoxification
#12
Maggie S Chen, Yue Zhang, Liangfang Zhang
A biomimetic micro/nanodevice is 3D bioprinted using polyethylene glycol (PEG) hydrogel as the supporting platform, along with the red blood cell (RBC) membrane-coated nanoparticles (RBC-NPs) encapsulated in the hydrogel as the detoxification mechanism. RBC-NPs are prepared through a nanoprecipitation and coating method and then mixed into the poly(ethylene glycol) diacrylate (PEGDA) monomer solution for 3D bioprinting through photopolymerization. This resulting detoxification device is engineered with multiple inner channels for the RBC-NPs to nonspecifically soak up the various toxins flowing through the channels...
September 20, 2017: Nanoscale
https://www.readbyqxmd.com/read/28929152/size-dependent-targeted-delivery-of-gold-nanoparticles-modified-with-the-il-6r-specific-aptamer-air-3a-to-il-6r-carrying-cells
#13
Lisa Prisner, Nadine Bohn, Ulrich Hahn, Alf Mews
The delivery of gold nanoparticles (AuNPs) to specific cells strongly depends on the properties e.g. the size of the particles and is of great interest for a large variety of biomedical applications. Here we investigated the size dependence of the receptor-ligand mediated AuNP delivery to cells by comparing very small "molecular" Au-clusters of only 2 nm to larger 7 nm and 36 nm AuNPs with a distinct surface plasmon resonance. Since the molecular weight in this range changes by almost three orders of magnitude, we show how the amount of gold relates to the number of delivered AuNPs...
September 20, 2017: Nanoscale
https://www.readbyqxmd.com/read/28928768/the-effectiveness-of-personalized-bowel-preparation-using-a-smartphone-camera-application-a-randomized-pilot-study
#14
Jae Won Jung, Jongha Park, Gi Jung Jeon, Young Soo Moon, Sung Yuon Yang, Tae Oh Kim, Eui Tay Jung, Hee-Cheol Kim
BACKGROUND: We aimed to investigate the effectiveness of a smartphone application that analyzes and judges the optimal dosage of polyethylene glycol (PEG) for bowel preparation. METHODS: Patients were assigned to use the smartphone camera application (app group) or written instructions (non-app group). The smartphone camera application was programmed to analyze the bowel preparation quality and automatically determine the dosage of PEG from an analysis of stool images...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28928753/peg-induces-high-expression-of-the-cell-cycle-checkpoint-gene-wee1-in-embryogenic-callus-of-medicago-truncatula-potential-link-between-cell-cycle-checkpoint-regulation-and-osmotic-stress
#15
Adel M Elmaghrabi, Hilary J Rogers, Dennis Francis, Sergio J Ochatt
Polyethylene glycol (PEG) can be used to mimic osmotic stress in plant tissue cultures to study mechanisms of tolerance. The aim of this experiment was to investigate the effects of PEG (M.W. 6000) on embryogenic callus of Medicago truncatula. Leaf explants were cultured on MS medium with 2 mg L(-1) NAA and 0.5 mg L(-1) BAP for 5 months. Then, calli were transferred to the same medium further supplemented with 10% (w/v) 6000 PEG for 6 months in order to study physiological and putative molecular markers of water stress...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28927842/synthesis-and-preparation-of-biodegradable-hybrid-dextran-hydrogel-incorporated-with-biodegradable-curcumin-nanomicelles-for-full-thickness-wound-healing
#16
Mona Alibolandi, Marzieh Mohammadi, Seyed Mohammad Taghdisi, Khalil Abnous, Mohammad Ramezani
There is a clinical need for a novel, more efficient therapy for full thickness wound healing. In the current study, curcumin encapsulated PEG-PLA [poly(lactide)-block-poly(ethylene glycol)] nanomicelles were incorporated into dextran hydrogel for a full thickness dermal wound healing application. To assess the application of the hydrogel as a therapeutic wound dressing, its morphology, swelling pattern, kinetics of degradation, and capacity to control curcumin release were evaluated. It was found that the prepared hybrid hydrogel had acceptable biocompatibility, incorporation capacity of curcumin nanomicelles, and mechanical properties...
September 16, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28927615/green-thermal-assisted-synthesis-and-characterization-of-novel-cellulose-mg-oh-2-nanocomposite-in-peg-naoh-solvent
#17
Nikolai Ponomarev, Eveliina Repo, Varsha Srivastava, Mika Sillanpää
Synthesis of nanocomposites was performed using microcrystalline cellulose (MCC), MgCl2 in PEG/NaOH solvent by a thermal-assisted method at different temperatures by varying time and the amount of MCC. Results of XRD, FTIR, and EDS mapping showed that the materials consisted of only cellulose (CL) and magnesium hydroxide (MH). According to FTIR and XRD, it was found that crystallinity of MH in cellulose nanocomposites is increased with temperature and heating time and decreased with increasing of cellulose amount...
November 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28925888/a-self-nanoemulsifying-drug-delivery-system-for-poorly-water-soluble-tolbutamide-development-optimization-and-pharmacodynamic-studies
#18
Deepti Pandita, Neelam Kumari, Viney Lather
The current investigation involves the development of a thermodynamically stable and dilutable self-nanoemulsifying drug delivery system (SNEDDS) for tolbutamide, a poorly water soluble hypoglycemic drug, in order to achieve higher water solubility and enhanced dissolution rate which in turn improves its oral bioavailability. Pseudo-ternary phase diagrams suggested the suitability of oleic acid (lipid), Tween 20 (surfactant) and PEG 400 (co-surfactant) for developing the SNEEDS formulations. The optimal SNEDDS formulation having mean globule diameter, viscosity, polydispersity value of 58...
September 15, 2017: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/28925709/effect-of-hydrophobic-chain-length-on-the-stability-and-guest-exchange-behavior-of-shell-sheddable-micelles-formed-by-disulfide-linked-diblock-copolymers
#19
Haiyan Fan, Yixia Li, Jinxian Yang, Xiaodong Ye
Reduction-responsive micelles hold enormous promise for the application as drug carriers due to the fast drug release triggered by reducing conditions and high anticancer activity. However, the effect of hydrophobic chain length on the stability and guest exchange of reduction-responsive micelles, especially for the micelles formed by diblock copolymers containing single disulfide group, are not fully understood. Here, shell-sheddable micelles formed by a series of disulfide-linked copolymer poly(ethylene glycol)-b-poly(-caprolactone) (PEG-SS-PCL) containing the same chain length of PEG but different chain lengths of hydrophobic block PCL were prepared and well characterized...
September 19, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28925678/dual-functionalized-graphene-oxide-based-sirna-delivery-system-for-implant-surface-bio-modification-with-enhanced-osteogenesis
#20
Li Zhang, Qing Zhou, Wen Song, Kaimin Wu, Yumei Zhang, Yimin Zhao
Surface functionalization by siRNA is a novel strategy for improved implant osseointegration. Gene delivery system with safety and high transfection activity is a crucial factor for siRNA-functionalized implant to exert its biological function. To this end, polyethylene glycol (PEG) and polyethylenimine (PEI) dual-functionalized graphene oxide (GO) (nGO-PEG-PEI) may present a promising siRNA vector. In this study, nano-sized nGO-PEG-PEI was prepared and optimized for siRNA delivery. Titania nanotubes (NT) fabricated by anodic oxidation were bio-modified with nGO-PEG-PEI/siRNA by cathodic electrodeposition, designated as NT-GPP/siRNA...
September 19, 2017: ACS Applied Materials & Interfaces
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