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https://www.readbyqxmd.com/read/28738657/a-new-strategy-for-fabrication-of-water-dispersible-and-biodegradable-fluorescent-organic-nanoparticles-with-aie-and-esipt-characteristics-and-their-utilization-for-bioimaging
#1
Dazhuang Xu, Meiying Liu, Hui Zou, Jianwen Tian, Hongye Huang, Qing Wan, Yanfeng Dai, Yuanqing Wen, Xiaoyong Zhang, Yen Wei
Fluorescence probes play a crucial role in optical imaging for visualization of complex biological processes. As compared with conventional organic fluorogens, the probes with aggregation-induced emission (AIE) and excited-state intramolecular proton transfer (ESIPT) characteristics show significant advantages in high quantum yield at concentrated and aggregated state, large Stokes shift and low cytotoxicity. However, the synthesis of AIE-active fluorescent probes through the ESIPT mechanism has received only very limited attention...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28738559/a-novel-dianionic-amino-acid-ionic-liquid-coated-peg-4000-modified-fe3o4-nanocomposite-for-the-magnetic-solid-phase-extraction-of-trypsin
#2
Qin Yang, Yuzhi Wang, Hongmei Zhang, Kaijia Xu, Xiaoxiao Wei, Panli Xu, Yigang Zhou
A novel magnetic extractant, PEG 4000 modified Fe3O4nanomaterial that coated with dianionic amino acid ionic liquid (Fe3O4@PEG@DAAAIL), was successfully synthesized and characterized. X-ray diffraction (XRD), transmission electron microscope (TEM), vibrating sample magnetometer (VSM), fourier transform infrared spectrometry (FT-IR), thermal gravimetric analysis (TGA) and zeta potentials were used to confirm that the novel nanocomposite was successfully synthesized. Subsequently, the prepared Fe3O4@PEG@DAAAIL nanocomposite was used as the extractant for trypsin coupled with magnetic solid-phase extraction (MSPE)...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28738228/streptavidin-hydrogel-prepared-by-sortase-a-assisted-click-chemistry-for-enzyme-immobilization-on-an-electrode
#3
Takuya Matsumoto, Yuki Isogawa, Tsutomu Tanaka, Akihiko Kondo
A tetrameric streptavidin (SA)-appended LPETG tag was site-specifically linked to azido-containing tri-glycine via sortase A catalysis and the resulting azido-modified SA (SA-N3) was retained in the biotin-binding pocket. SA-N3 was polymerized with dibenzylcyclooctyne-modified branched poly(ethyleneglycol) (DBCO-PEG) using azido-modified branched PEG (N3-PEG) as a spacer via copper-free click chemistry. The resulting SA-based hydrogel exhibited gel-like mechanical properties and could immobilize biotin-modified molecules through biotin-SA affinity...
July 19, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28737896/interfacial-shear-strength-and-adhesive-behavior-of-silk-ionomer-surfaces
#4
Sunghan Kim, Ren D Geryak, Shuaidi Zhang, Ruilong Ma, Rossella Calabrese, David L Kaplan, Vladimir V Tsukruk
The interfacial shear strength between different layers in multi-layered structures of layer-by-layer (LbL) microcapsules is a crucial mechanical property to ensure their robustness. In this work, we investigated the interfacial shear strength of modified silk fibroin ionomers utilized in LbL shells, an ionic-cationic pair with complimentary ionic pairing, (SF)-poly-L-glutamic acid (Glu) and SF- poly-L-lysine (Lys) and a complementary pair with partially screened Coulombic interactions due to the presence of poly(ethylene glycol) (PEG) segments, SF-Glu/SF-Lys[PEG] pair...
July 24, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28737462/co-delivery-of-hydrophilic-and-hydrophobic-drugs-by-micelles-a-new-approach-using-drug-conjugated-peg-pcl-nanoparticles
#5
H Danafar, K Rostamizadeh, S Davaran, M Hamidi
Co-delivery strategy has been proposed to minimize the amount of each drug and to achieve the synergistic effect for cancer therapies. A conjugate of the antitumor drug, doxorubicin, with diblock methoxy poly (ethylene glycol)-poly caprolactone (mPEG-PCL) copolymer was synthesized by the reaction of mPEG-PCL copolymer with doxorubicin in the presence of p-nitrophenylchloroformate. The conjugated copolymer was characterized in vitro by (1)H NMR, FTIR, DSC and GPC techniques. Then, the doxorubicin conjugated mPEG-PCL(DOX-mPEG-PCL) was self-assembled into micelles in the presence of curcumin in aqueous solution...
July 24, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28737439/systematic-review-and-meta-analysis-is-bowel-preparation-still-necessary-in-small-bowel-capsule-endoscopy
#6
Diana E Yung, Emanuele Rondonotti, Catherine Sykes, Marco Pennazio, John N Plevris, Anastastios Koulaouzidis
INTRODUCTION: Optimal bowel preparation for small bowel capsule endoscopy(SBCE) is controversial. This meta-analysis aimed to investigate the effects of laxatives in SBCE. METHODS: A comprehensive literature search was conducted for studies investigating the use of laxatives in SBCE. The primary outcome was diagnostic yield(DY) for SB findings; secondary outcomes SB visualization quality(SBVQ) and completion rate(CR). Pooled odds ratios(ORs) with 95% confidence intervals(CIs) and number needed to treat(NNT) were calculated...
July 24, 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28737432/integrin-targeted-nano-sized-polymeric-systems-for-paclitaxel-conjugation-a-comparative-study
#7
Anat Eldar-Boock, Rachel Blau, Claudia Ryppa, Hemda Baabur-Cohen, Ariel Many, María J Vicent, Felix Kratz, Joaquin Sanchis, Ronit Satchi-Fainaro
The generation of rationally-designed polymer therapeutics via the conjugation of low molecular weight anti-cancer drugs to water-soluble polymeric nanocarriers aims to improve the therapeutic index. Here, we focus on applying polymer therapeutics to target two cell compartments simultaneously - tumor cells and angiogenic endothelial cells. Comparing different polymeric backbones carrying the same therapeutic agent and targeting moiety may shed light on any correlation between the choice of polymer and the anti-cancer activity of the conjugate...
July 24, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28737384/physicochemical-parameters-affecting-the-electrospray-ionization-efficiency-of-amino-acids-after-acylation
#8
Jos Hermans, Sara Ongay, Vadym Markov, Rainer Bischoff
Electrospray ionization (ESI) is widely used in liquid chromatography coupled to mass spectrometry (LC-MS) for the analysis of biomolecules. However, the ESI process is still not completely understood and it is often a matter of trial and error to enhance ESI efficiency and hence the response of a given set of compounds. In this work we performed a systematic study of the ESI response of 14 amino acids that were acylated with organic acid anhydrides of increasing chain length and with polyethylene glycol (PEG) changing certain physicochemical properties in a predictable manner...
July 24, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28736857/non-covalent-assembly-method-that-simultaneously-endows-a-liposome-surface-with-targeting-ligands-protective-peg-chains-and-deep-red-fluorescence-reporter-groups
#9
Scott K Shaw, Wenqi Liu, Seamus Brennan, Maria Betancourt-Mendiola, Bradley D Smith
A new self-assembly method is used to rapidly functionalize the surface of liposomes without perturbing the membrane integrity or causing leakage of the aqueous contents. The key molecule is a cholesterol-squaraine-PEG conjugate with three important structural elements: a cholesterol membrane anchor, a fluorescent squaraine docking station that allows rapid and high-affinity macrocycle threading, and a long PEG-2000 chain to provide steric shielding of the decorated liposome. The two-step method involves spontaneous insertion of the conjugate into the outer leaflet of pre-formed liposomes followed by squaraine threading with a tetralactam macrocycle that has appended targeting ligands...
July 23, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28736782/ph-responsive-de-pegylated-nanoparticles-based-on-triphenylphosphine-quercetin-self-assemblies-for-mitochondria-targeted-cancer-therapy
#10
Lei Xing, Jin-Yuan Lyu, Yue Yang, Peng-Fei Cui, Liu-Qing Gu, Jian-Bin Qiao, Yu-Jing He, Tian-Qi Zhang, Minjie Sun, Jin-Jian Lu, Xiaojun Xu, Yu Liu, Hu-Lin Jiang
We have developed mitochondria-targeted self-assembled nanoparticles (NPs) based on amphiphilic triphenylphosphine-quercetin (TPP-Que) conjugates, which were further modified by poly(ethylene glycol) via a pH-responsive coordination bond to form TQ-PEG NPs. And it is revealed that the TQ-PEG NPs were more effective therapeutic agents compared with Que in vitro and in vivo.
July 24, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28736333/synthesis-and-characterization-of-a-multifunctional-gold-doxorubicin-nanoparticle-system-for-ph-triggered-intracellular-drug-release
#11
Ganesh V Khutale, Alan Casey
A nanoparticle drug carrier system has been developed to alter the cellular uptake and chemotherapeutic performance of an available chemotherapeutic drug. The system comprises of a multifunctional gold nanoparticle based drug delivery system (Au-PEG-PAMAM-DOX) as a novel platform for intracellular delivery of doxorubicin (DOX). Spherical gold nanoparticles were synthesized by a gold chloride reduction, stabilized with thiolated polyethylene glycol (PEG) and then covalently coupled with a polyamidoamine (PAMAM) G4 dendrimer...
July 20, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28736294/enhanced-neuroprotection-of-anthocyanin-loaded-peg-gold-nanoparticles-against-a%C3%AE-1-42-induced-neuroinflammation-and-neurodegeneration-via-the-nf-kb-jnk-gsk3%C3%AE-signaling-pathway
#12
Min Ju Kim, Shafiq Ur Rehman, Faiz Ul Amin, Myeong Ok Kim
Amyloid-beta (Aβ1-42) plaques and neurofibrillary tangles (NFTs) are the main hallmarks considered to be associated with neuroinflammation in Alzheimer's disease (AD). Recently, nanoparticle-based targeted drug delivery approaches have been found to be a useful tool in the neurotherapeutics field. Therefore, we examined and compared the neuroprotective effect of anthocyanins alone and anthocyanin-loaded poly (ethylene glycol)-gold nanoparticles (PEG-AuNPs) in Aβ1-42-injected mouse and in vitro models of AD...
July 20, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28736015/fibrosing-cholestatic-hepatitis-c-after-liver-transplantation-therapeutic-options-before-and-after-introduction-of-direct-acting-antivirals-our-experience-and-literature-review
#13
O Tronina, K Ślubowska, N Mikołajczyk-Korniak, E Komuda-Leszek, R Wieczorek-Godlewska, B Łągiewska, M Pacholczyk, W Lisik, M Kosieradzki, M Durlik
BACKGROUND: Cirrhosis caused by hepatitis C is the most common indication for liver transplantation. The most aggressive form of hepatitis C virus (HCV) relapse after liver transplantation is fibrosing cholestatic hepatitis C, which can be observed in 2% to 15% of recipients. METHODS: Double therapy with peg-interferon and ribavirin was characterized by low antiviral response, rapid fibrosis, and frequent graft failure within 1 year after surgery. RESULTS: Introduction of direct-acting antivirals for HCV treatment allows for more efficient therapy with less adverse reactions, including patients with fibrosing cholestatic hepatitis C...
July 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28733754/the-influence-of-imagery-capacity-in-motor-performance-improvement
#14
Célia Ruffino, Charalambos Papaxanthis, Florent Lebon
Motor imagery (MI) training improves motor performance, but the inter-individual variability of this improvement remains still unexplored. In this study, we tested the influence of imagery ability on the performance improvement following MI training. Twenty participants were randomly distributed into the MI or control group. They actually performed, at pre- and post-test sessions, a revisited version of the Nine Hole Peg Test, a speed-accuracy trade-off task, commonly used in clinics. Between the tests, the MI group mentally trained on the task (5 blocks of 10 trials), while the control group watched a non-emotional documentary...
July 21, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28733283/osmotic-compounds-enhance-antibiotic-efficacy-against-acinetobacter-baumannii-biofilm-communities
#15
Azeza Falghoush, Haluk Beyenal, Thomas E Besser, Anders Omsland, Douglas R Call
Biofilm-associated infections are a clinical challenge in part because a hydrated matrix protects the bacterial community from antibiotics. Herein, we evaluated how different osmotic compounds [maltodextrin, sucrose and polyethylene glycol (PEG)] enhance antibiotic efficacy against Acinetobacter baumannii biofilm communities. Established test-tube biofilms (24 h, strain ATCC 17978) were treated with osmotic compounds in the presence or absence of 10X the minimum inhibitory concentration of different antibiotics (50 μg/ml tobramycin, 20 μg/ml ciprofloxacin, 300 μg/ml chloramphenicol, 30 μg/ml nalidixic acid or 100 μg/ml erythromycin)...
July 21, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28732931/ultrasound-assisted-synthesis-of-ph-responsive-nanovector-based-on-peg-chitosan-coated-magnetite-nanoparticles-for-5-fu-delivery
#16
Sepideh Khoee, Ali Saadatinia, Reza Bafkary
pH-responsive magnetic carriers at the nanoscale are one of the most important agents for the targeted treatment of cancer. In this study, Fe3O4 nanoparticles were prepared by co-precipitation method and functionalized with three types of PEG using ultrasound waves. PEGlated particles were modified with chitosan shell through ultrasound-assisted double emulsion method. The prepared material which was used as a pH responsive carrier for pinpointed 5-FU delivery. The chemico-physical properties of prepared nanoparticles have been investigated...
November 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28732712/structure-performance-relationships-of-temperature-responsive-plga-peg-plga-gels-for-sustained-release-of-bmp-2
#17
A Santoveña, C Monzón, C Alvarez-Lorenzo, C Del Rosario, A Delgado, C Evora, A Concheiro, M Llabrés, J B Fariña
PLGA-PEG-PLGA synthesis conditions have an impact on the physicochemical features of the copolymer and its usefulness as biomaterial. This study reports on an analysis of the composition and structural properties of PLGA-PEG-PLGA copolymers applying a variety of analytical techniques. Viscoelastic properties and particularly the temperature-responsive behavior of PLGA-PEG-PLGA showed a marked dependence on copolymer structural features. Physicochemical and biological properties, such as bioadhesion, biocompatibility and cell viability, of the raw copolymers and their gels were also evaluated...
July 18, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28732254/going-down-the-tubes-impact-on-seizure-control-of-antiepileptic-medication-given-via-percutaneous-feeding-tubes
#18
REVIEW
Caryn Jory, Rohit Shankar, Katy Oak, Janina Oates, Mike Wilcock
BACKGROUND: Long-term feeding by percutaneous endoscopic gastrostomy tube (PEG) is uncommon but can present significant issues when both nutrition and medication have to be fed down the same tube. This is especially important in people with epilepsy where the dose and bioavailability of antiepileptic drugs are critical to maintain adequate seizure control. This group with long-term PEG tubes is particularly vulnerable and dependent on their carers to provide high standard of care. Indeed, approximately half of the people with long-term feeding tubes suffer from severe intellectual disability which requires careful coordination of all members of the multidisciplinary team...
July 18, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28732179/kgf-enhances-oral-epithelial-adhesion-and-rete-peg-elongation-via-integrins
#19
G L Sa, X P Xiong, J G Ren, J Y Wang, H F Xia, Z K Liu, S G He, Y F Zhao
Oral epithelial adhesion to the lamina propria underlies the physiologic function of the oral mucosa and contributes to resisting bacterial invasion, preventing body fluid loss, and maintaining routine chewing; thus, understanding the factors that positively influence oral epithelial adhesion is a research topic of great interest. Rete pegs contribute to oral epithelial adhesion by enlarging the contact areas, whereas integrins are the major molecules that mediate epithelial cell adhesion to the basement membrane...
July 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28731705/reversible-self-assembly-of-degradable-polymersomes-with-upper-critical-solution-temperature-in-water
#20
Thomas Wolf, Timo Rheinberger, Johanna Simon, Frederik R Wurm
Temperature-induced self-assembly of block copolymers allows the formation of smart nanodimensional structures. Mostly, non-degradable LCST segments are applied to prepare such dynamic aggregates. However, degradable UCST block copolymers that would allow the swelling or disassembly at elevated temperatures with eventual backbone hydrolysis have not been reported to date. We present the first well-defined degradable poly(phosphonate)s with adjustable UCST. The organocatalytic anionic ring-opening copolymerization of 2-alkyl-2-oxo-1,3,2-dioxaphospholanes provided functional polymers with excellent control over molecular weight and copolymer composition...
July 21, 2017: Journal of the American Chemical Society
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