keyword
https://read.qxmd.com/read/38536819/stem-cell-derived-vessels-on-chip-for-cardiovascular-disease-modeling
#1
JOURNAL ARTICLE
Maren Marder, Caroline Remmert, Julius A Perschel, Munkhtur Otgonbayar, Christine von Toerne, Stefanie Hauck, Judith Bushe, Annette Feuchtinger, Bilal Sheikh, Michel Moussus, Matthias Meier
The metabolic syndrome is accompanied by vascular complications. Human in vitro disease models are hence required to better understand vascular dysfunctions and guide clinical therapies. Here, we engineered an open microfluidic vessel-on-chip platform that integrates human pluripotent stem cell-derived endothelial cells (SC-ECs). The open microfluidic design enables seamless integration with state-of-the-art analytical technologies, including single-cell RNA sequencing, proteomics by mass spectrometry, and high-resolution imaging...
March 26, 2024: Cell Reports
https://read.qxmd.com/read/38536791/intrauterine-and-early-life-malnutrition-in-rats-disrupts-the-circadian-rhythm-programming-of-energy-metabolites-through-adulthood
#2
JOURNAL ARTICLE
Dulce Jocelyn Bustamante-Valdez, Martin Alejandro Fuentes-Cano, Jesus Salvador Gonzalez-Ruano, Alonso Martinez-Canabal, Rene Cardenas-Vazquez, Pilar Duran
Maternal malnutrition plays a crucial role in functional development, resulting in behavioral, cognitive, and metabolic abnormalities and disturbances. "Cafeteria diet" has been linked to obesity, metabolic syndrome, diabetes, and other metabolic disruptions in the mammalian lifespan. However, there are very few reports about the effect of intrauterine and early postnatal malnutrition on the circadian rhythm programming of energy metabolites. In mammals, circadian rhythm central control is fundamental for correct interaction with the environment and physiological regulation...
2024: PloS One
https://read.qxmd.com/read/38536781/comparison-of-metabolic-risk-factors-lipid-indices-healthy-eating-index-and-physical-activity-among-premenopausal-menopausal-and-postmenopausal-women
#3
JOURNAL ARTICLE
Leila Moradi, Sayed Jalal Hashemi, Ferdos Zaman, Meysam Alipour, Zahra Farhangiyan, Maryam Sharifzadeh
INTRODUCTION: In this study, we aimed to compare metabolic risk factors, lipid indices, healthy eating index, and physical activity among premenopausal, menopausal, and postmenopausal women. METHODS: In this cross-sectional study, a total of 4,732 women participating in the Hoveyzeh Cohort Study were placed into three groups of premenopausal (n=736), menopausal (n=396), and postmenopausal (n=917) women, according to the inclusion and exclusion criteria . RESULTS: The prevalence of metabolic syndrome was 43...
March 27, 2024: Romanian Journal of Internal Medicine
https://read.qxmd.com/read/38535334/relationships-and-mendelian-randomization-of-gut-microbe-derived-metabolites-with-metabolic-syndrome-traits-in-the-metsim-cohort
#4
JOURNAL ARTICLE
Sahereh Mirzaei, Holli A DeVon, Rita M Cantor, Arjen J Cupido, Calvin Pan, Sung Min Ha, Lilian Fernandes Silva, James R Hilser, Jaana Hartiala, Hooman Allayee, Federico E Rey, Markku Laakso, Aldons J Lusis
The role of gut microbe-derived metabolites in the development of metabolic syndrome (MetS) remains unclear. This study aimed to evaluate the associations of gut microbe-derived metabolites and MetS traits in the cross-sectional Metabolic Syndrome In Men (METSIM) study. The sample included 10,194 randomly related men (age 57.65 ± 7.12 years) from Eastern Finland. Levels of 35 metabolites were tested for associations with 13 MetS traits using lasso and stepwise regression. Significant associations were observed between multiple MetS traits and 32 metabolites, three of which exhibited particularly robust associations...
March 20, 2024: Metabolites
https://read.qxmd.com/read/38535100/metabolic-dysfunction-associated-liver-disease-in-patients-undergoing-coronary-computed-tomography-angiography
#5
JOURNAL ARTICLE
Rares Ilie Orzan, Rares Ioan Gligor, Renata Agoston, Carmen Cionca, Alexandru Zlibut, Raluca Pais, Andrada Seicean, Lucia Agoston-Coldea
In this single-center cross-sectional study on patients undergoing coronary computed tomography angiography (CCTA), we assessed the prognostic significance of metabolic dysfunction associated steatotic liver disease (MASLD), metabolic syndrome (MetS), and CCTA-derived parameters for predicting major adverse cardiovascular events (MACE). Over a mean follow-up of 26.9 months, 2038 patients were analyzed, with 361 (17.7%) experiencing MACE. MASLD was associated with a higher MACE incidence (25.90% vs. 14.71% without MASLD, p < 0...
February 26, 2024: Journal of Cardiovascular Development and Disease
https://read.qxmd.com/read/38534729/assessment-of-the-pro-renin-receptor-protein-expression-in-organs
#6
JOURNAL ARTICLE
Teng-Yao Yang, Pey-Jium Chang, Yu-Shien Ko, Siou-Ru Shen, Shun-Fu Chang
The (pro)renin receptor ((P)RR) is an essential component of the renin-angiotensin system (RAS) as a specific single-pass transmembrane receptor for prorenin and renin and has now emerged as a multifunctional protein implicated in a wide variety of developmental and physio-pathological processes and pathways. The (P)RR may be of pathological significance in metabolic syndrome. The (P)RR has received much consideration; substantial efforts have been made to understand the localization, regulation, and function of the (P)RR at both a molecular and system level...
February 25, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38533958/associations-of-alcohol-consumption-with-left-atrial-morphology-and-function-in-a-population-at-high-cardiovascular-risk
#7
JOURNAL ARTICLE
Aniqa B Alam, Estefania Toledo-Atucha, Dora Romaguera, Angel M Alonso-Gómez, Miguel A Martínez-Gonzalez, Lucas Tojal-Sierra, Marta Noris Mora, Caterina Mas-Llado, Linzi Li, Ines Gonzalez-Casanova, Jordi Salas-Salvadó, Montserrat Fitó, Alvaro Alonso
BACKGROUND: Excessive alcohol consumption has been associated with increased risk of atrial fibrillation, although the underlying mechanisms remain unclear. An enlarged left atrium and impaired left atrial function may lead to atrial fibrillation. The association of alcohol consumption with structural and functional left atrial measures, however, has received limited attention. METHODS AND RESULTS: We studied 503 participants from the PREDIMED-Plus (Prevención con Dieta Mediterránea) trial, a randomized trial testing intensive weight loss intervention with an energy-reduced Mediterranean diet and physical activity promotion in preventing cardiovascular disease in adults with metabolic syndrome...
March 27, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38533737/combined-effects-of-smoking-and-alcohol-consumption-on-the-risk-of-liver-cancer-according-to-metabolic-syndrome-a-nested-case-control-study-in-south-korea
#8
JOURNAL ARTICLE
Thi Tra Bui, Eunjung Park, Hee-Yeon Kang, Jin-Kyoung Oh
Tobacco and alcohol may interact to increase the risk of liver cancer, which might be modified by other risk factors. Their combined effects in the context of metabolic syndrome (MetS) remain unclear. Given the increasing prevalence of MetS, this nested case-control study was conducted to evaluate the combined effects of smoking and alcohol consumption on liver cancer risk with stratification by MetS. We included 15,352 liver cancer patients and 92,112 matched controls who attended the nationwide general health examination during 2009-2019, using a customized database (N = 5,545,835) from the Korean National Health Insurance Service...
March 27, 2024: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/38533569/mangiferin-a-potential-supplement-to-improve-metabolic-syndrome-current-status-and-future-opportunities
#9
JOURNAL ARTICLE
Gelin Xiang, Sa Guo, Nan Xing, Qinyun Du, Jing Qin, Huimin Gao, Yi Zhang, Shaohui Wang
Metabolic syndrome (MetS) represents a considerable clinical and public health burden worldwide. Mangiferin (MF), a flavonoid compound present in diverse species such as mango (Mangifera indica L.), papaya ( Pseudocydonia sinensis (Thouin) C. K. Schneid.), zhimu ( Anemarrhena asphodeloides Bunge), and honeybush tea ( Cyclopia genistoides), boasts a broad array of pharmacological effects. It holds promising uses in nutritionally and functionally targeted foods, particularly concerning MetS treatment. It is therefore pivotal to systematically investigate MF's therapeutic mechanism for MetS and its applications in food and pharmaceutical sectors...
March 26, 2024: American Journal of Chinese Medicine
https://read.qxmd.com/read/38533552/taar1-agonist-ulotaront-delays-gastric-emptying-of-solids-in-patients-with-schizophrenia-and-concurrent-metabolic-syndrome-with-prediabetes
#10
JOURNAL ARTICLE
Snežana Milanović, Nina Dedic, Robert Lew, Duane Burton, Kenneth S Koblan, Michael Camilleri, Seth C Hopkins
BACKGROUND: Metabolic syndrome (MetS), which can be induced or exacerbated by the current class of antipsychotic drugs, is highly prevalent in patients with schizophrenia and presents significant challenges to lifetime disease management. Supported by initial clinical results, trace amine-associated receptor 1 (TAAR1) agonists have emerged as potential novel treatments for schizophrenia. Notably, non-clinical studies have also shown weight-lowering and glucoregulatory effects of TAAR1 agonists, including the investigational agent ulotaront...
March 27, 2024: Diabetes, Obesity & Metabolism
https://read.qxmd.com/read/38533267/triglyceride-glucose-index-as-an-indicator-of-cardiovascular-risk-in-syrian-refugees
#11
JOURNAL ARTICLE
Ameerah Hasan Ibrahim, Alaa Mahmoud Hammad, Walid Al-Qerem, Hakam Alaqabani, F Scott Hall, Fawaz Alasmari
BACKGROUND: The triglyceride glucose (TyG) index is a quick and inexpensive approach to measure insulin resistance. The aim of this study was to evaluate the TyG index's ability to predict cardiovascular risk and determine the TyG index cutoff values in Syrian refugees. METHODS: A retrospective research study was conducted with 756 Syrian refugees. Data on demographics and clinical laboratory assessments were obtained from refugee's files. The formula Ln [fasting triglycerides (mg/dL) × fasting plasma glucose (mg (dL)/2] was used to calculate the TyG index...
2024: Diabetes, Metabolic Syndrome and Obesity
https://read.qxmd.com/read/38533266/the-regulation-role-of-the-gut-islets-axis-in-diabetes
#12
REVIEW
Songtao Yang, Jie Cao, Chuan Sun, Li Yuan
The gut-islets axis is an important endocrine signaling axis that regulates the function of islets by modulating the gut micro-environment and its endocrine metabolism. The discovery of intestinal hormones, such as GLP-1 and GIP, has established a preliminary link between the gut and the islet, paving the way for the development of GLP-1 receptor agonists based on the regulation theory of the gut-islets axis for diabetes treatment. This discovery has created a new paradigm for diabetes management and rapidly made the regulation theory of the gut-islets axis a focal point of research attention...
2024: Diabetes, Metabolic Syndrome and Obesity
https://read.qxmd.com/read/38532900/roles-of-organokines-in-intervertebral-disc-homeostasis-and-degeneration
#13
REVIEW
Yuxin He, Sheng Liu, Hui Lin, Fan Ding, Zengwu Shao, Liming Xiong
The intervertebral disc is not isolated from other tissues. Recently, abundant research has linked intervertebral disc homeostasis and degeneration to various systemic diseases, including obesity, metabolic syndrome, and diabetes. Organokines are a group of diverse factors named for the tissue of origin, including adipokines, osteokines, myokines, cardiokines, gastrointestinal hormones, and hepatokines. Through endocrine, paracrine, and autocrine mechanisms, organokines modulate energy homeostasis, oxidative stress, and metabolic balance in various tissues to mediate cross-organ communication...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38532033/pcsk9-plasma-concentration-is-associated-with-epicardial-adipose-tissue-volume-and-metabolic-control-in-patients-with-type-1-diabetes
#14
JOURNAL ARTICLE
Helena Sardà, Cristina Colom, Sonia Benitez, Gemma Carreras, Judit Amigó, Inka Miñambres, David Viladés, Francisco Blanco-Vaca, Jose Luís Sanchez-Quesada, Antonio Pérez
Patients with type 1 diabetes (T1D) have a greater risk of cardiovascular disease. Proconvertase subtilisin-kexin 9 (PCSK9) is involved in the atherosclerosis process. This study aimed to determine the relationship between PCSK9 levels and epicardial adipose tissue (EAT) volume and cardiometabolic variables in patients with T1D. This was an observational cross-sectional study including 73 patients with T1D. Clinical, biochemical and imaging data were collected. We divided the patients into two groups according to their glycemic control and the EAT index (iEAT) percentile...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38531912/author-correction-machine-learning-analysis-for-the-association-between-breast-feeding-and-metabolic-syndrome-in-women
#15
Jue Seong Lee, Eun-Saem Choi, Hwasun Lee, Serhim Son, Kwang-Sig Lee, Ki Hoon Ahn
No abstract text is available yet for this article.
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38531533/2023-obesity-fact-sheet-prevalence-of-obesity-and-abdominal-obesity-in-adults-adolescents-and-children-in-korea-from-2012-to-2021
#16
JOURNAL ARTICLE
Su-Min Jeong, Jin-Hyung Jung, Ye Seul Yang, Wonsock Kim, In Young Cho, You-Bin Lee, Kye-Yeung Park, Ga Eun Nam, Kyungdo Han
BACKGROUND: The 2023 Obesity Fact Sheet aims to present an updated overview of obesity prevalence across all age groups, including children and adolescents. METHODS: This study included individuals aged ≥20 years who underwent health checkups provided by the Korean National Health Insurance Service between 2012 and 2021. The prevalence of obesity and abdominal obesity was standardized by age and sex using data from the 2010 population and housing census. For children and adolescents (6 to 18 years), we used the Korea National Health and Nutrition Examination Survey (2012 to 2021), and obesity was defined by the corresponding sex- and age-specific body mass index percentile of 95th or greater based on the 2017 Korean National Growth Chart for Children and Adolescents...
March 27, 2024: Journal of obesity & metabolic syndrome
https://read.qxmd.com/read/38531383/short-term-effectiveness-and-potential-factors-of-ustekinumab-based-on-real-world-data-in-chinese-psoriasis-patients
#17
JOURNAL ARTICLE
Xingyu Li, Xiaowen Xie, Jiashuai Li, Jingjin Hu, Kun Hu, Minjia Tan, Jing Yang, Sichun Deng, Yijie Liu, Mi Zhang, Yehong Kuang, Junchen Chen, Liqiu Liao, Wu Zhu
BACKGROUND: As one of the most effective biologic treatments for psoriasis, the short-term effectiveness of ustekinumab has yet to be studied extensively. OBJECTIVE: The purpose of this study was to evaluate the short-term effectiveness and potential factors within four weeks after the first-dose ustekinumab treatment based on real-world data. METHODS: The study enrolled 98 patients with moderate-to-severe psoriasis, given ustekinumab 45 mg at week 0, week 4, and then every 12 weeks...
December 2024: Journal of Dermatological Treatment
https://read.qxmd.com/read/38531330/err%C3%AE-1-and-aromatase-expression-in-human-placental-tissues-from-term-deliveries-of-large-for-gestational-age-lga-newborns
#18
JOURNAL ARTICLE
Marcos Abdul Palligas, Cristina Patricia Nemer, Claudia Monica Cannizzaro, Maria Sonia Baquedano, Alicia Belgorosky, Nora Saraco
INTRODUCTION: Being born either large (LGA) or small for gestational age (SGA) has been associated with an increased risk of developing metabolic syndrome in adulthood. However, the mechanism underlying this early programming remained unclear. Estrogen-related receptor gamma (ERRγ) is an orphan nuclear receptor with a high expression in human placenta, particularly ERRγ1. ERRγ has been proposed to play a central role in controlling genes involved in energy metabolism...
March 26, 2024: Hormone Research in Pædiatrics
https://read.qxmd.com/read/38531323/large-neutral-amino-acids-moderate-the-effects-of-metabolic-syndrome-on-cognitive-performance-in-middle-aged-adults
#19
JOURNAL ARTICLE
Cherry Youn, Marie L Caillaud, Yanrong Li, Isabelle A Gallagher, Barbara Strasser, Dietmar Fuchs, Hirofumi Tanaka, Andreana P Haley
Introduction Two large neutral amino acids (LNAA), tryptophan and tyrosine, are precursors to cerebral neurotransmitters and are involved in cognitive function. Higher levels of LNAA in young adults are associated with improved cognition, although these associations appear to reverse over time. Given that exposure to metabolic syndrome (MetS) may induce premature cognitive aging, the current project aims to fill the gap in the literature by examining the effect of LNAA on cognitive performance in midlife adults with metabolic risks...
March 26, 2024: Annals of Nutrition & Metabolism
https://read.qxmd.com/read/38530242/hypertension-and-risk-of-endometrial-cancer-a-pooled-analysis-in-the-epidemiology-of-endometrial-cancer-consortium-e2c2
#20
JOURNAL ARTICLE
Talar S Habeshian, Noah C Peeri, Immaculata De Vivo, Leo J Schouten, Xiao-Ou Shu, Michele L Cote, Kimberly A Bertrand, Yu Chen, Megan A Clarke, Tess V Clendenen, Linda S Cook, Laura Costas, Luigino Dal Maso, Jo L Freudenheim, Christine M Friedenreich, Grace Gallagher, Gretchen L Gierach, Marc T Goodman, Susan J Jordan, Carlo La Vecchia, James V Lacey, Fabio Levi, Linda M Liao, Loren Lipworth, Lingeng Lu, Xavier Matías-Guiu, Kirsten B Moysich, George L Mutter, Renhua Na, Jeffin Naduparambil, Eva Negri, Kelli O'Connell, Tracy A O'Mara, Irene Onieva Hernández, Julie R Palmer, Fabio Parazzini, Alpa V Patel, Kathryn L Penney, Anna E Prizment, Fulvio Ricceri, Harvey A Risch, Carlotta Sacerdote, Sven Sandin, Rachael Z Stolzenberg-Solomon, Piet A van den Brandt, Penelope M Webb, Nicolas Wentzensen, Akemi T Wijayabahu, Lynne R Wilkens, Wanghong Xu, Herbert Yu, Anne Zeleniuch-Jacquotte, Wei Zheng, Mengmeng Du, Veronica Wendy Setiawan
BACKGROUND: The incidence rates of endometrial cancer (EC) are increasing, which may partly be explained by the rising prevalence of obesity, an established risk factor for EC. Hypertension, another component of metabolic syndrome, is also increasing in prevalence, and emerging evidence suggests that it may be associated with the development of certain cancers. The role of hypertension independent of other components of metabolic syndrome in the etiology of EC remains unclear. In this study we evaluated hypertension as an independent risk factor for EC and whether this association is modified by other established risk factors...
March 26, 2024: Cancer Epidemiology, Biomarkers & Prevention
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