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F Salamanna, V Borsari, D Contartese, N Nicoli Aldini, M Fini
Different fields of cancer management consider bone health to be of increasing clinical importance for patients: 1) presence of bone metastases in many solid tumors, 2) use of bone-targeted treatments in the reduction of bone metastasis, 3) effects of cancer treatment on reproductive hormones, critical for normal bone remodeling maintenance. Additionally, bone microenvironment is further complicated by the decline of ovarian sex steroid production and by the related increase in inflammatory factors linked to menopause, which result in accelerated bone loss and increased risk of osteoporosis (OP)...
June 22, 2018: Breast: Official Journal of the European Society of Mastology
Esther Gil-Barrionuevo, José Maria Balibrea, Enric Caubet, Oscar Gonzalez, Ramón Vilallonga, José Manuel Fort, Andrea Ciudin, Manel Armengol
INTRODUCTION: Pheochromocytomas are infrequent tumors arised from the chromaphine cells of the adrenal sympathetic system. The excess of circulating catecholamines may lead to different cardiovascular disorders from silent alterations of the myocardial conduction to different forms of cardiomyopathy. The onset as cardiogenic shock is exceptional. PRESENTATION OF CASE: A 35-year-old male, with a known history of acute myopericarditis of unknown origin which debuted as acute pulmonary edema, was admitted with dyspnea in the context of a new heart failure episode with pulmonary edema...
June 27, 2018: International Journal of Surgery Case Reports
Richard L Hesketh, Kevin M Brindle
Hyperpolarization of 13 C-labeled substrates can increase their 13 C NMR signal by more than 10000-fold, which has allowed magnetic resonance imaging (MRI) of metabolic reactions in vivo. This has already provided a unique insight into the dysregulated metabolic pathways and microenvironment of tumors. Perhaps the best known of the cancer-associated metabolic aberrations is the Warburg effect, which has been imaged in patients using hyperpolarized [1-13 C]pyruvate. In clinical oncology there is a requirement to diagnose tumors earlier, better determine their aggressiveness and prognosis, identify novel treatment targets and detect response to treatment earlier...
July 11, 2018: Current Opinion in Chemical Biology
Sophie Sixou, Katharina Müller, Stéphan Jalaguier, Christina Kuhn, Nadia Harbeck, Doris Mayr, Jutta Engel, Udo Jeschke, Nina Ditsch, Vincent Cavaillès
New markers are needed to improve diagnosis and to personalize treatments for patients with breast cancer (BC). Receptor-interacting protein of 140 kDa (RIP140) and ligand-dependent corepressor (LCoR), two transcriptional co-regulators of estrogen receptors, strongly interact in BC cells. Although their role in cancer progression has been outlined in the last few years, their function in BC has not been elucidated yet. In this study, we investigated RIP140 and LCoR localization (cytoplasm vs nucleus) in BC samples from a well-characterized cohort of patients (n = 320)...
July 11, 2018: Translational Oncology
Xueting Hu, Jincai Luo
Lymphangiogenesis and increased expression of lymphangiogenic growth factors are associated with high rate of lymph node (LN) metastasis and with poor prognosis in some, but not all, solid tumors. In addition to its involvement in metastasis, lymphangiogenesis has been shown to have other roles in tumor pathogenesis, such as the niche function of tumor stem cells and regulatory functions of anti-tumor immune responses. On the other hand, evidence has accumulated that tumor-induced lymphangiogenesis displays the heterogeneity in gene signature, structure, cellular origins and functional plasticity...
July 14, 2018: Cancer Science
Prasath Sathiah, Priyadarshini Dehuri, Debasis Gochhait
A 32 year old male patient presented at the fine needle aspiration (FNA) clinic with slow progressive swellings on bilateral Achilles tendon (Figure: 1 Left larger than right) for more than 3 years. The clinical diagnosis was bilateral giant cell tumor of tendon sheath. The patient also carried an MRI report (performed elsewhere- T2 weighted image) which highlighted the soft tissue lesions in the bilateral tendon with speckled hyperintensity and focal thickening (Figure II). This article is protected by copyright...
July 14, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
Konstantinos Kosmas, Georgia Mitropoulou, Ioannis Provatas, Marios Stamoulas, Anna Marouga
OBJECTIVE: The aims of this study were to determine the expression of PTEN in endometrial adenocarcinomas (as a potential prognostic indicator before treatment) in imprint smears and to correlate the results with clinicopathologic parameters of primary untreated endometrial cancer patients. METHODS: One hundred twenty-six patients with endometrial carcinoma were evaluated with samples freshly resected after a total abdominal hysterectomy during a 29-month period...
July 14, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
Rachel B Ger, Jinzhong Yang, Yao Ding, Megan C Jacobsen, Carlos E Cardenas, Clifton D Fuller, Rebecca M Howell, Heng Li, R Jason Stafford, Shouhao Zhou, Laurence E Court
PURPOSE: Magnetic resonance imaging (MRI) provides non-invasive evaluation of patient's anatomy without using ionizing radiation. Due to this and the high soft-tissue contrast, MRI use has increased and has potential for use in longitudinal studies where changes in patients' anatomy or tumors at different time points are compared. Deformable image registration can be useful for these studies. Here we describe two data sets that can be used to evaluate the registration accuracy of systems for MR images, as it cannot be assumed to be the same as that measured on CT images...
July 14, 2018: Medical Physics
Silvia Darb-Esfahani, Ivonne Kolaschinski, Fabian Trillsch, Sven Mahner, Nicole Concin, Ignace Vergote, Els Van Nieuwenhuysen, Patriciu Achimas-Cadariu, Joanna Glajzer, Hannah Woopen, Stephan Wienert, Eliane Tabea Taube, Mandy Stanske, Hagen Kulbe, Carsten Denkert, Jalid Sehouli, Elena Ioana Braicu
OBJECTIVE: Advanced-stage ovarian high-grade serous carcinoma (HGSC) is a poor-prognosis cancer, however a small and poorly characterized subset of patients shows long-term survival. We aimed to establish a cohort of HGSC long-term survivors for histopathological and molecular analysis. METHODS: Paraffin blocks from 151 patients with primary FIGO III/IV HGSC and progression-free survival (PFS) >5 years were collected within the Tumorbank Ovarian Cancer (TOC) Network...
July 14, 2018: Histopathology
Firas G Petros, Aradhana M Venkatesan, Diana Kaya, Chaan S Ng, Bryan M Fellman, Jose A Karam, Christopher G Wood, Surena F Matin
OBJECTIVES: To determine conditional survival for patients with small renal masses (SRM) undergoing active surveillance (AS). MATERIALS AND METHODS: Patients were enrolled in a prospective AS protocol at our institution between May 2005 and January 2016. Patients with SRM ≤4cm with serial cross-sectional imaging available in-house for review were included. Overall survival (OS) was estimated using Kaplan-Meier method and modeled via Cox proportional hazards models...
July 14, 2018: BJU International
Jian-Bo Shao, Xiang-Qian Luo, Yong-Jin Wu, Mao-Gang Li, Jing-Yi Hong, Li-Hua Mo, Zhi-Gang Liu, Hua-Bin Li, Da-Bo Liu, Ping-Chang Yang
BACKGROUND: The interleukin (IL)-10 expression in B cells plays an important role in immune tolerance. The regulation of IL-10 expression in B cells is not fully understood yet. Tumor necrosis factor (TNF) is increased in allergic rhinitis (AR) patients. This study tests a hypothesis that TNF enhances histone deacetylase (HDAC)11 expression to inhibit the expression of IL-10 in B cells of AR patients. METHODS: Peripheral B cells were collected from healthy persons and patients with AR...
July 14, 2018: International Forum of Allergy & Rhinology
Alexander E Druy, Egor V Shorikov, Grigory A Tsaur, Alexander M Popov, Artem N Zaychikov, Sergey N Tuponogov, Leonid I Saveliev, Godelieve A M Tytgat, Larisa G Fechina
BACKGROUND: Detection of bone marrow (BM) involvement in patients with neuroblastoma is crucial for staging and defining prognosis. Furthermore, the persistence of residual tumor cells in the BM is associated with an unfavorable outcome. METHODS: Expression of PHOX2B, TH, ELAVL4, and B4GALNT1 (GD2-synthase) was analyzed by quantitative polymerase chain reaction in neuroblastoma cell lines, control BM samples, and in BM samples from patients. The threshold level of expression for each gene was established through receiver operator characteristic analysis and used to determine the diagnostic test performance...
July 14, 2018: Pediatric Blood & Cancer
Norihiro Honda, Katsunori Ishii, Yoshinaga Kajimoto, Toshihiko Kuroiwa, Kunio Awazu
The optical properties of human brain tumor tissues, including glioblastoma, meningioma, oligodendroglioma, and metastasis, that were classified into "strong," "vague," and "unobservable" fluorescence by a neurosurgeon were measured and compared. The optical properties of the tissues were measured with a double integrating sphere and the inverse Monte Carlo technique from 350 to 1000 nm. Using reasons of ex-vivo measurement, the optical properties at around 420 nm were potentially affected by the hemoglobin content in tissues...
July 2018: Journal of Biomedical Optics
Roshni Roy, Raju Kandimalla, Fuminori Sonohara, Masahiko Koike, Yasuhiro Kodera, Naoki Takahashi, Yasuhide Yamada, Ajay Goel
Treatment modalities in esophageal squamous cell carcinoma (ESCC) depend largely on lymph node metastasis (LNM) status. With sub-optimal detection sensitivity of existing imaging techniques, we propose a methylation signature which identifies patients with LNM with greater accuracy. This would allow precise stratification of high-risk patients requiring more aggressive treatment from low-risk ESCC patients who can forego radical surgery. An unbiased genome-wide methylation signature for LNM detection was established from an initial in-silico discovery phase...
July 14, 2018: International Journal of Cancer. Journal International du Cancer
Kiki C Andree, Anouk Mentink, Leonie L Zeune, Leon W M M Terstappen, Nikolas H Stoecklein, Rui P Neves, Christiane Driemel, Rita Lampignano, Liwen Yang, Hans Neubauer, Tanja Fehm, Johannes C Fischer, Elisabetta Rossi, Mariangela Manicone, Umberto Basso, Piero Marson, Rita Zamarchi, Yohann Loriot, Valerie Lapierre, Vincent Faugeroux, Marianne Oulhen, Françoise Farace, Gemma Fowler, Mariane Sousa Fontes, Berni Ebbs, Maryou Lambros, Mateus Crespo, Penny Flohr, Johann S de Bono
Frequently, the number of circulating tumor cells (CTC) isolated in 7.5 mL of blood is too small to reliably determine tumor heterogeneity and to be representative as a 'liquid biopsy'. In the EU FP7 program CTCTrap, we aimed to validate and optimize the recently introduced Diagnostic LeukApheresis (DLA) to screen liters of blood. Here we present the results obtained from 34 metastatic cancer patients subjected to DLA in the participating institutions. 7.5 mL blood processed with CellSearch was used as 'gold standard' reference...
July 14, 2018: International Journal of Cancer. Journal International du Cancer
Isaac Nardi, Theresa Reno, Xinwei Yun, Terra Sztain, Jami Wang, Huifang Dai, Li Zheng, Jae Kim, Dan Raz
In the last decade, it has become clear that epigenetic changes act together with genetic mutations to promote virtually every stage of tumorigenesis and cancer progression. This knowledge has triggered searches for "epigenetic drugs" that can be developed into new cancer therapies. Here we report that triptolide reduced lung cancer incidence from 70% to 10% in a Fen1 E160D transgenic mouse model and effectively inhibited cancer growth and metastasis in A549 and H460 mouse xenografts. We found that triptolide induced lung cancer cell apoptosis that was associated with global epigenetic changes to histone 3 (H3)...
July 14, 2018: International Journal of Cancer. Journal International du Cancer
Teiko Sakurai, Hidenori Kusumoto, Tomoko Wakasa, Yoshio Ohta, Eiichi Konishi, Hiroyuki Shiono
BACKGROUND: Epithelioid sarcoma (ES) is a rare variant of soft tissue sarcoma. The proximal type of ES occurs in various locations. We present a resected case with proximal-type ES that occurred in the chest wall and discuss the relevant literature. CASE PRESENTATION: A 47-year-old woman was referred for a 6-month history of a right anterior chest mass with tenderness. Chest computed tomography showed an invasive chest wall mass with calcification surrounding the third rib...
July 13, 2018: Surgical Case Reports
D I Vodolazhsky, D S Kutilin, Kh A Mogushkova, O I Kit
Cancer-testis antigens, effective markers of tissue malignant transformation, are characterized by heterogonous transcription depending on the pathological features of breast cancer. We performed screening of transcription profile of cancer-testis antigens specific for breast tumor tissues in female patients with and without regional metastasis. The relative expression of 16 genes (MAGEA1, MAGEA2, MAGEA3, MAGEA4, MAGEB1, MAGEB2, GAGE1, GAGE3, GAGE4, MAGEC1, BAGE, XAGE3, NY-ESO1, SSX2, SYCP1, and PRAME1) was analyzed by RT-qPCR method in biopsy specimens of the mammary gland tissues obtained during surgery from 25 patients...
July 14, 2018: Bulletin of Experimental Biology and Medicine
N P Bgatova, S A Bakhbaeva, Yu S Taskaeva, V V Makarova, Yu I Borodin
Structural changes in the liver of CBA mice were studied during the development of experimental hepatocarcinoma-29 inoculated into the hip. A decrease in the volume density of hepatocyte cytoplasm, mitochondria, endoplasmic reticulum, and lipid inclusions and an increase in the volume density of lysosomal structures during tumor growth were observed. All stages of intracellular autophagy were recorded by the method of electron microscopy. These stages included the appearance of autophagosomes, autophagolysosomes, and secondary lysosomes in the hepatocyte cytoplasm...
July 13, 2018: Bulletin of Experimental Biology and Medicine
Fang Xie, Huawei Cai, Fangyu Peng
Copper 8-hydroxyquinoline-2-carboxaldehyde-thiosemicarbazide complex (CuHQTS) is a copper complex with strong anticancer activity against cisplatin-resistant neuroblastoma and prostate cancer cells in vitro by cell proliferation assay or fluorescent microscopic imaging. This study aimed to evaluate anti-prostate cancer activity of CuHQTS in vivo by bioluminescence imaging (BLI) and tumor size measurement, using athymic nu/nu mice implanted with prostate cancer cells carrying luciferase reporter gene (Luc-PC3)...
July 13, 2018: Journal of Biological Inorganic Chemistry: JBIC
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