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Yunnan Fang, Mitra Akbari, Jimmy G D Hester, Lauri Sydänheimo, Leena Ukkonen, Manos M Tentzeris
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
April 16, 2018: Scientific Reports
Camila M Mano, Thais Guaratini, Karina H M Cardozo, Pio Colepicolo, Etelvino J H Bechara, Marcelo P Barros
Astaxanthin (ASTA) is a ketocarotenoid found in many marine organisms and that affords many benefits to human health. ASTA is particularly effective against radical-mediated lipid peroxidation, and recent findings hypothesize a "mitochondrial-targeted" action of ASTA in cells. Therefore, we examined the protective effects of ASTA against lipid peroxidation in zwitterionic phosphatidylcholine liposomes (PCLs) and anionic phosphatidylcholine: phosphatidylglycerol liposomes (PCPGLs), at different pHs (6...
April 12, 2018: Marine Drugs
Sigal Zilcha-Mano, J Christopher Muran, Catherine F Eubanks, Jeremy D Safran, Arnold Winston
OBJECTIVE: It has been demonstrated that patient perspective on alliance can predict subsequent treatment outcome as reported by the therapist but not the other way around. This study aimed to investigate the circumstances in which therapists can provide estimations of alliance capable of predicting patient perceptions of subsequent session outcome. The study focused on 2 potential indicators: time in treatment and treatment efficacy. METHOD: Data of 107 treatment completers assigned to either cognitive-behavioral therapy or alliance focused therapy were analyzed...
April 2018: Journal of Consulting and Clinical Psychology
Julian A Rubel, Sigal Zilcha-Mano, Viola Feils-Klaus, Wolfgang Lutz
OBJECTIVE: The concept of alliance ruptures has had a large impact on contemporary studies of the alliance. Although this debate mainly focuses on the effect of ruptures and repairs on subsequent alliance and outcome levels within patients, to date no study has actually examined these within-patient effects. The present study fills this lacuna by examining the effect of alliance ruptures and in-session repairs on alliance ratings and symptom impairment in the subsequent session, accounting for the temporal sequence of ruptures and symptom impairment...
April 2018: Journal of Consulting and Clinical Psychology
Fukutaro Mano, Kuo-Chung Chang, Tomiya Mano
Purpose: To report a case of surgical repair of traumatic rhegmatogenous retinal detachment combined with congenital falciform retinal detachment (FRD). Methods: A retrospective case report. Results: A 36-year-old man with traumatic rhegmatogenous retinal detachment complicating a previously known FRD was successfully treated despite residual FRD following pars plana lensectomy, vitrectomy, and encircling scleral buckling. His best corrected visual acuity improved from hand motion at 50 cm to 20/1,000...
January 2018: Case Reports in Ophthalmology
Roy Mano, Hanan Goldberg, Yariv Stabholz, Danny Hazan, David Margel, Daniel Kedar, Jack Baniel, Ofer Yossepowitch
OBJECTIVES: To compare the incidence rate of urinary tract infections and associated pathogens between patients with an ileal conduit and an orthotopic neobladder urinary diversion. METHODS: The medical records of 179 patients treated with radical cystectomy between 2006-2011 were reviewed and data pertaining to postoperative UTI was collected. UTI incidence was reported at 3 months' intervals and compared by diversion type. Preoperative predictors of UTI were evaluated with Cox regression analyses...
April 4, 2018: Urology
Masafumi Kikuchi, Masaki Tanaka, Shinya Takasaki, Akiko Takahashi, Miki Akiba, Yasushi Matsuda, Masafumi Noda, Kanehiko Hisamichi, Hiroaki Yamaguchi, Yoshinori Okada, Nariyasu Mano
Background: Mycophenolic acid (MPA) treatment requires therapeutic drug monitoring to improve the outcome after organ transplantation. The aim of this study was to compare two methods, a particle enhanced turbidimetric inhibition immunoassay (PETINIA) and a reference liquid chromatography tandem mass spectrometry (LC-MS/MS) for determining plasma MPA concentrations from Japanese lung transplant recipients. Methods: Plasma MPA concentrations were determined from 20 Japanese lung transplant recipients using LC-MS/MS and the PETINIA on the Dimension Xpand Plus-HM analyzer...
2018: Journal of Pharmaceutical Health Care and Sciences
Shota Okuno, Takayuki Ishihara, Osamu Iida, Shin Okamoto, Kiyonori Nanto, Toshiaki Mano
No abstract text is available yet for this article.
April 2, 2018: Cardiovascular Intervention and Therapeutics
Toshiaki Mano
No abstract text is available yet for this article.
2018: International Heart Journal
Ryujiro Sasanabe, Mamiko Mano, Atsuhiko Nomura, Toshiaki Shiomi
No abstract text is available yet for this article.
March 30, 2018: Internal Medicine
Sajjad Ahmad, Saad Raza, Asma Abro, Klaus R Liedl, Syed Sikander Azam
KdsB (3-deoxy-manno-octulosonate cytidylyltransferase) is a highly specific and selective bacterial enzyme that catalyzes KDO (3-Deoxy-D-mano-oct-2-ulosonic acid) activation in KDO biosynthesis pathway. Failure in KDO biosynthesis causes accumulation of lipid A in the bacterial outer membrane that leads to cell growth arrest. This study reports a combinatorial approach comprising virtual screening of natural drugs library, molecular docking, computational pharmacokinetics, molecular dynamics simulation, and binding free energy calculations for the identification of potent lead compounds against the said enzyme...
March 31, 2018: Journal of Biomolecular Structure & Dynamics
Suzanne Sheppard-Law, Iryna Zablotska-Manos, Melissa Kermeen, Susan Holdaway, Alice Lee, Jacob George, Amany Zekry, Lisa Maher
AIMS AND OBJECTIVES: This study aimed to investigate HCC screening utilisation and factors associated with utilisation among patients prescribed HBV anti-viral therapy and at risk of HCC. BACKGROUND: The incidence of hepatocellular carcinoma (HCC) has increased in Australia over the past three decades with chronic hepatitis B virus (HBV) infection a major contributor. HCC surveillance programs aim to detect cancers early enabling curative treatment options, longer survival and longer times to recurrence...
March 31, 2018: Journal of Clinical Nursing
Solene Gentil, Marie Carriere, Serge Cosnier, Sébastien Gounel, Nicolas Mano, Alan Le Goff
In this work, the direct electrochemistry of bilirubin oxidase from Magnaporthe orizae (MoBOD) was studied on CNTs functionalized by electrografting several types of diazonium salts. The functionalization induces favorable or unfavorable orientation of MoBOD, the latter being compared to the well-known BOD from Myrothecium verrucaria (MvBOD). On the same nanostructured electrodes, MoBOD can surpass MvBOD in terms of both current densities and minimal overpotentials. Added to the fact that MoBOD is also highly active at gas-diffusion electrode (GDE), these findings make MoBOD, one of the MCOs with the highest catalytic activity towards ORR...
March 30, 2018: Chemistry: a European Journal
Mano Soshi, Takahiro Mizuta, Yasuharu Tokuda
No abstract text is available yet for this article.
March 2018: Journal of General and Family Medicine
Christoforos D Giannaki, Panagiotis Aristotelous, Manos Stefanakis, Georgios M Hadjigeorgiou, Mauro Manconi, Eleni Leonidou, Giorgos K Sakkas, Marios Pantzaris
Objectives Restless legs syndrome (RLS) symptoms are common in Multiple Sclerosis (MS) patients. The aim of the current study was to examine for the first time whether RLS could affect the functional capacity and various contributing parameters related to quality of life and fatigue in MS patients. Methods According to their RLS status, 50 relapsing-remitting MS patients were divided into the RLS (n = 10) and non-RLS groups (n = 40). Specific questionnaires were used in order to assess the health-related quality of life (HRQoL), fatigue levels, sleep quality, daily sleepiness, and depression symptoms of the patients...
March 26, 2018: Neurological Research
Lúcia F Santos, Ilídio J Correia, A Sofia Silva, João F Mano
The limited efficiency of conventional drugs has been instigated the development of new and more effective drug delivery systems (DDS). Transdermal DDS, are associated with numerous advantages such its painless application and less frequent replacement and greater flexibility of dosing, features that triggered the research and development of such devices. Such systems have been produced using either biopolymer; or synthetic polymers. Although the first ones are safer, biocompatible and present a controlled degradation by human enzymes or water, the second ones are the most currently available in the market due to their greater mechanical resistance and flexibility, and non-degradation over time...
March 20, 2018: European Journal of Pharmaceutical Sciences
Arianna Bellazzo, Giulio Di Minin, Elena Valentino, Daria Sicari, Denis Torre, Luigi Marchionni, Federica Serpi, Michael B Stadler, Daniela Taverna, Gaia Zuccolotto, Isabella Monia Montagner, Antonio Rosato, Federica Tonon, Cristina Zennaro, Chiara Agostinis, Roberta Bulla, Miguel Mano, Giannino Del Sal, Licio Collavin
The tumor suppressor DAB2IP contributes to modulate the network of information established between cancer cells and tumor microenvironment. Epigenetic and post-transcriptional inactivation of this protein is commonly observed in multiple human malignancies, and can potentially favor progression of tumors driven by a variety of genetic mutations. Performing a high-throughput screening of a large collection of human microRNA mimics, we identified miR-149-3p as a negative post-transcriptional modulator of DAB2IP...
March 22, 2018: Cell Death and Differentiation
Rayna D Markin, Sigal Zilcha-Mano
This paper argues that there is a cultural taboo against the public recognition and expression of perinatal grief that hinders parents' ability to mourn and their psychological adjustment following a loss. It is proposed that this cultural taboo is recreated within the therapy relationship, as feelings of grief over a perinatal loss are minimized or avoided by the therapist and parent or patient. Importantly, it is suggested that if these cultural dynamics are recognized within the therapy relationship, then psychotherapy has the immense opportunity to break the taboo by validating the parent's loss as real and helping the parent to mourn within an empathic and affect-regulating relationship...
March 2018: Psychotherapy
Francesca Andriani, Maria Teresa Majorini, Miguel Mano, Elena Landoni, Rosalba Miceli, Federica Facchinetti, Mavis Mensah, Enrico Fontanella, Matteo Dugo, Mauro Giacca, Ugo Pastorino, Gabriella Sozzi, Domenico Delia, Luca Roz, Daniele Lecis
BACKGROUND: Fibroblasts are crucial mediators of tumor-stroma cross-talk through synthesis and remodeling of the extracellular matrix and production of multiple soluble factors. Nonetheless, little is still known about specific determinants of fibroblast pro-tumorigenic activity in lung cancer. Here, we aimed at understanding the role of miRNAs, which are often altered in stromal cells, in reprogramming fibroblasts towards a tumor-supporting phenotype. METHODS: We employed a co-culture-based high-throughput screening to identify specific miRNAs modulating the pro-tumorigenic potential of lung fibroblasts...
March 20, 2018: Journal of Hematology & Oncology
Monica Samuel Avila, Silvia Moreira Ayub-Ferreira, Mauro Rogerio de Barros Wanderley Junior, Fatima das Dores Cruz, Sara Michelly Gonçalves Brandão, Vagner Oliveira Carvalho Rigaud, Marilia Higushi-Dos-Santos, Ludhmila Abrahão Hajjar, Roberto Kalil Filho, Paulo Marcelo Hoff, Marina Sahade, Marcela S M Ferrari, Romulo Leopoldo de Paula Costa, Max Senna Mano, Cecilia Beatriz Bittencourt Viana Cruz, Maria Cristina Abduch, Marco Stephan Lofrano Alves, Guilherme Veiga Guimaraes, Victor Sarli Issa, Marcio Sommer Bittencourt, Edimar Alcides Bocchi
BACKGROUND: Anthracycline (ANT) chemotherapy is associated with cardiotoxicity. Prevention with β-blockers remains controversial. OBJECTIVE: The aim of this prospective, randomized, double-blind, placebo-controlled study was to evaluate the role of carvedilol in preventing ANT cardiotoxicity. METHODS: We randomized 200 patients with HER2-negative breast cancer tumor status and normal left ventricular ejection fraction (LVEF) referred for ANT (240 mg/m2 ) to receive carvedilol or placebo until chemotherapy completion...
March 3, 2018: Journal of the American College of Cardiology
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