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Kyoko Takashima, Yuichi Maru, Seiichi Mori, Hiroyuki Mano, Tetsuo Noda, Kaori Muto
BACKGROUND: Platforms for sharing genomic and phenotype data have been developed to promote genomic research, while maximizing the utility of existing datasets and minimizing the burden on participants. The value of genomic analysis of trios or family members has increased, especially in rare diseases and cancers. This article aims to argue the necessity of protection when sharing data from both patients and family members. MAIN TEXT: Sharing patients' and family members' data collectively raises an ethical tension between the value of datasets and the rights of participants, and increases the risk of re-identification...
June 18, 2018: BMC Medical Ethics
Sangkil Kim, Apostolos Georgiadis, Manos M Tentzeris
The detailed design considerations for the printed RFID-based sensor system is presented in this paper. Starting from material selection and metallization method, this paper discusses types of RFID-based sensors (single- & dual-tag sensor topologies), design procedures, and performance evaluation methods for the wireless sensor system. The electrical properties of the paper substrates (cellulose-based and synthetic papers) and the silver nano-particle-based conductive film are thoroughly characterized for RF applications up to 8 GHz...
June 17, 2018: Sensors
Daisuke Imai, Tomoharu Yoshizumi, Kazuhito Sakata, Toru Ikegami, Shinji Itoh, Noboru Harada, Takashi Motomura, Takeo Toshima, Yohei Mano, Yuji Soejima, Yoshihiko Maehara
BACKGROUND: Although risk factors for the long-term mortality of liver transplantation are well described, there is a lack of detailed study regarding these factors for adult living donor liver transplantation (LDLT). METHODS: We retrospectively analyzed 528 adult LDLT recipients in our hospital. The risk factors were analyzed for overall deaths >5 years post-LDLT. RESULTS: Over the 20-year follow-up, 137 patients died. Patient survival at 1, 3, 5, and 10 years post-LDLT was 87...
June 13, 2018: Transplantation
Takahito Sugase, Tomoki Makino, Makoto Yamasaki, Koji Tanaka, Tadayoshi Hashimoto, Yasuhiro Miyazaki, Tsuyoshi Takahashi, Yukinori Kurokawa, Kiyokazu Nakajima, Masayuki Mano, Eiichi Morii, Masaki Mori, Yuichiro Doki
INTRODUCTION: We aimed to analyze the clinical and histological effects of chemotherapy in superficial esophageal squamous cell carcinoma (SESCC). METHODS: We analyzed tumor samples from five patients with cT1bN1M0 who underwent subtotal esophagectomy following two courses of a new triplet chemotherapy regimen including docetaxel, cisplatin, and 5-fluorouracil (DCF). To assess the histological effects of chemotherapy, resected specimens were analyzed by macroscopic examination, hematoxylin & eosin (HE) staining, immunohistochemical (IHC) staining (p53, Ki-67 and cytokeratin) and periodic acid-Schiff (PAS) staining...
June 16, 2018: Esophagus: Official Journal of the Japan Esophageal Society
Takeyuki Tsuchida, Tatsuo Mano, Kagari-Koshi-Mano, Taro Bannai, Tomoyasu Matsubara, Satoshi Yamashita, Toshikazu Ushijima, Kenichi Nagata, Shigeo Murayama, Tatsushi Toda, Shoji Tsuji, Atsushi Iwata
Lewy body disease (LBD) is characterized by accumulation of aggregated α-synuclein in the central nervous system as eosinophilic cytoplasmic inclusions called Lewy bodies. According to their distribution pattern, it is classified into brainstem LBD, limbic LBD and diffuse neocortical LBD. It has been reported that α-synuclein affects various points in the MAPK cascade but its relationship with FGF receptors, which are the most upstream of the pathway, has not been previously investigated. We discovered that among the four FGFRs, FGFR3 showed neuronal upregulation in LBD brains histopathologically...
June 14, 2018: Brain Research
Alvaro J Leite, Ana I Gonçalves, Marcia T Rodrigues, Manuela E Gomes, João F Mano
The present work explores bioactive glass nanoparticles (BGNPs) and developed strontium-doped nanoparticles (BGNPsSr), envisioning orthopedic strategies compatible with vascularization. The nanoparticles were synthesized by sol-gel, achieving a diameter of 55 nm for BGNPs and of 75 nm for BGNPsSr, and the inclusion of strontium caused none structural alteration. The nanoparticles exhibited high cytocompatibility for HUVECs and SaOS-2. Additionally, the incorporation of strontium emphasized the tubule networking behavior of HUVECs...
June 15, 2018: ACS Applied Materials & Interfaces
Fuminori Hyodo, Takeya Sho, Maity Basudev, Kenta Fujita, Yoko Tachibana, Satoko Akashi, Megumi Mano, Yuki Hishikawa, Masayuki Matsuo, Tomoko Nakaji, Takafumi Ueno
We report construction of an artificial protein needle (PN), which includes the membrane puncturing needle domain of bacteriophage T4, conjugated to Mn carbonyl (MnCO) complexes. The responsiveness to visible light of the MnCO complex makes it useful as a photo-induced in vivo magnetic resonance imaging contrast reagent (MRI CR) because the PN carrier has the potential to deliver the MnCO complex into mouse tumors with retention of coordination structure within the in vivo environment. Moreover, the composite has higher relaxivity and longer circulation as an MRI CR than the corresponding MnCO complex...
June 15, 2018: Chemistry: a European Journal
Hidekazu Nishigori, Taku Obara, Toshie Nishigori, Mami Ishikuro, Kasumi Sakurai, Tetsuro Hoshiai, Masatoshi Saito, Ikuma Fujiwara, Takahiro Arima, Kunihiko Nakai, Shinichi Kuriyama, Nariyasu Mano, Hirohito Metoki, Nobuo Yaegashi
We evaluated the relationship between preconception folic acid supplementation and the occurrence of neural tube defects in offspring, using data from the Japan Environment and Children's Study (a nationwide prospective birth cohort study) database. Of 92,269 participants with single pregnancies, 74 cases (offspring or fetuses) had neural tube defects, including 32 cases of spina bifida, 24 cases of anencephaly, and 19 cases of encephalocele. A total of 7,634 participants (8.27%) used preconception folic acid supplementation, and of these, 621 (0...
June 13, 2018: Congenital Anomalies
Yohei Mano, Tomoharu Yoshizumi, Kyohei Yugawa, Masafumi Ohira, Takashi Motomura, Takeo Toshima, Shinji Itoh, Noboru Harada, Toru Ikegami, Yuji Soejima, Yoshihiko Maehara
BACKGROUND: Recent studies revealed that systemic inflammation was correlated with poorer prognosis in various cancers. We investigated the prognostic value of the lymphocyte-to-monocytes ratio (LMR) in patients who underwent living donor liver transplantation (LDLT) for hepatocellular carcinoma (HCC). METHODS: We retrospectively analyzed the records of 216 patients who underwent LDLT for HCC. Patients were divided into high- (n = 126) and low- (n = 90) LMR groups...
June 12, 2018: Liver Transplantation
Athanasios Bogris, Junpeng Wang, Manos Anyfantakis, Benoit Loppinet, Stephen L Craig, Hans-Jürgen Butt, George Fytas
The formation of permanent structures upon mild red laser illumination in transparent polydiene solutions is examined in the case of gem-dichlorocyclopropanated polybutadiene (gDCC-PB) polymers bearing 15% functional units of the dichlorocyclopropane groups. The response were found to be distinct from the precursor PB. Whereas fiber-like patterns were clearly observed in both precursor and gDCC-PB solutions in cyclohexane, these were absent in the case of gDCC-PB/ chloroform but were present in the precursor PB/chloroform solutions...
June 11, 2018: Journal of Physical Chemistry. B
Amelia Fiske
In September 2013, President Correa balanced himself on a felled log over an oil waste pit in the Ecuadorian Amazon. Extending a bare hand dripping with crude, he launched La Mano Sucia de Chevron campaign, demanding accountability for decades of contamination. This article explores the role of bodily knowledge in witnessing industrial contamination and struggles for environmental justice. Situating the mano sucia in the history of activism in the region, I show how the juxtaposition of different hands within the same motif reveals profoundly asymmetric relationships to the toxic entanglements that oil produces...
June 1, 2018: Social Studies of Science
Duncan A Hauser, Al Keuter, John D McVay, Andrew L Hipp, Paul S Manos
PREMISE OF THE STUDY: The California Floristic Province (CA-FP) is a unique and diverse region of floral endemism, yet the timing and nature of divergence and diversification of many lineages remain underexplored. We seek to elucidate the evolutionary history of the red oaks of the CA-FP, the Agrifoliae. METHODS: We collected PstI-associated RAD-seq data as well as morphometrics from individuals of the four species across their ranges, including varieties and hybrids...
October 2017: American Journal of Botany
Diana Rabadjieva, Antonina Kovacheva, Stefka Tepavitcharova, Manos Dassenakis, Sotirios Karavoltsos
Trace metals pollution of surface waters and their nearby soils in the metallurgically polluted Kardjali region, Bulgaria, were studied. Thermodynamic modeling including the dissolved organic carbon (DOC) was carried out for evaluating the distribution of metal species in waters and soil solutions. Zn was found to be the most widespread pollutant in the water samples, followed by Cu, Mn, and Cd. Geoaccumulation indices of trace metals for the tested soils were calculated, indicating that regarding Al, Fe, Co, Ni, and Cu all soils are "uncontaminated"...
June 7, 2018: Environmental Monitoring and Assessment
Hua Zhao, David Chang, Yuanqing Ye, Jie Shen, Wong-Ho Chow, Xifeng Wu
The relationship between blood mitochondrial DNA (mtDNA) copy number and subsequent cancer risk has been investigated previously. However, such association has never been examined in Mexican Americans. In the current study, we examined association between social-demographic factors and blood mtDNA copy number, as well as longitudinal relationship between cancer and mtDNA copy number, among 10,802 Mexican Americans in the Mano-A-Mano Mexican American Cohort. Overall, mtDNA copy number was statistically significantly higher among participants who developed cancer during the study period than among cancer-free controls (0...
May 22, 2018: Oncotarget
James C Spilsbury, Daphna Gross-Manos, Bridget M Haas, Kristina Bowdrie, Francisca Richter, Jill E Korbin, David S Crampton, Claudia J Coulton
Although approximately one-fifth of child maltreatment reports originate with family members, friends, neighbors, or community members, their efforts to identify and report child maltreatment are still not well understood. Nor is it well understood how these individuals' perceptions of what constitutes maltreatment may change over time. This study examined descriptions of behavior perceived as maltreatment by caregivers of minors in Cleveland, Ohio, USA neighborhoods. Data were obtained from two neighborhood-based cross-sectional surveys of caregivers of minors: one conducted in 1995-1996 and the other in 2014-2015...
June 2, 2018: Child Abuse & Neglect
Dana Tzur Bitan, Sigal Zilcha-Mano, Ori Ganor, Lior Biran, Yuval Bloch
Support groups for parents of children with Autistic Spectrum Disorders (ASD) are very common in public mental health settings. These groups have been found to be helpful in reducing parental stress and providing parents with professional knowledge as well as peer support. Clinical experience, as well as parents' verbal feedback, often indicates that within these groups there are occasionally unmet needs that are not expressed during sessions. In this article we describe the benefits of using routine measurement and feedback as means to identify and address such needs...
June 2018: Psychotherapy
Shinya Takasaki, Yoshihide Kawasaki, Masafumi Kikuchi, Masaki Tanaka, Masato Suzuka, Aoi Noda, Yuji Sato, Shinichi Yamashita, Koji Mitsuzuka, Hideo Saito, Akihiro Ito, Hiroaki Yamaguchi, Yoichi Arai, Nariyasu Mano
BACKGROUND: The aim was to investigate the relationships between total sunitinib plasma concentrations (sunitinib plus its active metabolite; N-desethyl sunitinib) and clinical outcomes in Japanese patients with metastatic renal cell carcinoma (mRCC). METHODS: Twenty patients with mRCC were enrolled following treatment with sunitinib. To assess safety, the total sunitinib concentration range up to discontinuation of treatment and dosage reduction associated with adverse events within 6 weeks from initiating administration were analyzed...
June 2, 2018: International Journal of Clinical Oncology
Maria P Sousa, Ana I Neto, Tiago R Correia, Sónia P Miguel, Michiya Matsusaki, Ilídio J Correia, João F Mano
Bioinspired and adhesive multilayer membranes are produced using the layer-by-layer (LbL) assembly of chitosan (CHT), alginate (ALG) and hyaluronic acid modified with dopamine (HA-DN). Freestanding multilayer membranes without DN are also produced as a control. The success of the synthesis of HA-DN was confirmed using UV-visible spectroscopy. Scanning electron microscopy images indicate that the surface of the DN-containing membranes is more porous than the control ones; they also present a higher average thickness value for the same number of CHT/ALG/CHT/HA(-DN) tetralayers (n = 100)...
May 31, 2018: Biomaterials Science
Manos L Moraitis, Irini Tsikopoulou, Antonios Geropoulos, Panagiotis D Dimitriou, Nafsika Papageorgiou, Marianna Giannoulaki, Vasilis D Valavanis, Ioannis Karakassis
Marine habitat assessment using indicator species through Species Distribution Modeling (SDM) was investigated. The bivalves: Corbula gibba and Flexopecten hyalinus were the indicator species characterizing disturbed and undisturbed areas respectively in terms of chlorophyll a concentration in Greece. The habitat suitability maps of these species reflected the overall ecological status of the area. The C. gibba model successfully predicted the occurrence of this species in areas with increased physical disturbance driven by chlorophyll a concentration, whereas the habitat map for F...
May 24, 2018: Marine Environmental Research
Kenji Kita, Takuho Ishii, Koichiro Hotta, Yuji Mano
E6005, a novel phosphodiesterase 4 inhibitor, is currently under clinical development for the treatment of atopic dermatitis. To support pediatric clinical trials, the dried blood spot assay for simultaneous determination of E6005 and its main metabolite, ER-392710 (M11), has been developed using ultra-performance liquid chromatography with tandem mass spectrometry. E6005 and M11, in 25 μL blood spotted onto FTA™ DMPK-C cards, were extracted by water/acetonitrile (1:1, v/v), and then chromatographed on a reversed phase column under gradient elution...
May 22, 2018: Journal of Pharmaceutical and Biomedical Analysis
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