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https://www.readbyqxmd.com/read/28636652/integrative-analysis-of-genomic-alterations-in-triple-negative-breast-cancer-in-association-with-homologous-recombination-deficiency
#1
Masahito Kawazu, Shinya Kojima, Toshihide Ueno, Yasushi Totoki, Hiromi Nakamura, Akiko Kunita, Wei Qu, Jun Yoshimura, Manabu Soda, Takahiko Yasuda, Natsuko Hama, Mihoko Saito-Adachi, Kazuhito Sato, Shinji Kohsaka, Eirin Sai, Masako Ikemura, Shigeru Yamamoto, Tomoko Ogawa, Masashi Fukayama, Keiichiro Tada, Yasuyuki Seto, Shinichi Morishita, Shoichi Hazama, Tatsuhiro Shibata, Yoshihiro Yamashita, Hiroyuki Mano
Triple-negative breast cancer (TNBC) cells do not express estrogen receptors, progesterone receptors, or human epidermal growth factor receptor 2. Currently, apart from poly ADP-ribose polymerase inhibitors, there are few effective therapeutic options for this type of cancer. Here, we present comprehensive characterization of the genetic alterations in TNBC performed by high coverage whole genome sequencing together with transcriptome and whole exome sequencing. Silencing of the BRCA1 gene impaired the homologous recombination pathway in a subset of TNBCs, which exhibited similar phenotypes to tumors with BRCA1 mutations; they harbored many structural variations (SVs) with relative enrichment for tandem duplication...
June 21, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28630331/distinguishing-attosecond-electron-electron-scattering-and-screening-in-transition-metals
#2
Cong Chen, Zhensheng Tao, Adra Carr, Piotr Matyba, Tibor Szilvási, Sebastian Emmerich, Martin Piecuch, Mark Keller, Dmitriy Zusin, Steffen Eich, Markus Rollinger, Wenjing You, Stefan Mathias, Uwe Thumm, Manos Mavrikakis, Martin Aeschlimann, Peter M Oppeneer, Henry Kapteyn, Margaret Murnane
Electron-electron interactions are the fastest processes in materials, occurring on femtosecond to attosecond timescales, depending on the electronic band structure of the material and the excitation energy. Such interactions can play a dominant role in light-induced processes such as nano-enhanced plasmonics and catalysis, light harvesting, or phase transitions. However, to date it has not been possible to experimentally distinguish fundamental electron interactions such as scattering and screening. Here, we use sequences of attosecond pulses to directly measure electron-electron interactions in different bands of different materials with both simple and complex Fermi surfaces...
June 19, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28627701/mangiferin-positively-regulates-osteoblast-differentiation-and-suppresses-osteoclast-differentiation
#3
Yuusuke Sekiguchi, Hiroshi Mano, Sachie Nakatani, Jun Shimizu, Aya Kataoka, Kana Ogura, Yoshifumi Kimira, Midori Ebata, Masahiro Wada
Mangiferin is a polyphenolic compound present in Salacia reticulata. It has been reported to reduce bone destruction and inhibit osteoclastic differentiation. This study aimed to determine whether mangiferin directly affects osteoblast and osteoclast proliferation and differentiation, and gene expression in MC3T3‑E1 osteoblastic cells and osteoclast‑like cells derived from primary mouse bone marrow macrophage cells. Mangiferin induced significantly greater WST‑1 activity, indicating increased cell proliferation...
June 12, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28620829/appearance-of-cell-adhesion-factor-in-osteoblast-proliferation-and-differentiation-of-apatite-coating-titanium-by-blast-coating-method
#4
Hirotsugu Umeda, Takamitsu Mano, Koji Harada, Ferdous Tarannum, Yoshiya Ueyama
We have already reported that the apatite coating of titanium by the blast coating (BC) method could show a higher rate of bone contact from the early stages in vivo, when compared to the pure titanium (Ti) and the apatite coating of titanium by the flame spraying (FS) method. However, the detailed mechanism by which BC resulted in satisfactory bone contact is still unknown. In the present study, we investigated the importance of various factors including cell adhesion factor in osteoblast proliferation and differentiation that could affect the osteoconductivity of the BC disks...
August 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28613878/kinetics-of-light-induced-concentration-patterns-in-transparent-polymer-solutions
#5
Manos Anyfantakis, Andreas Pamvouxoglou, Christos Mantzaridis, Stergios Pispas, Hans-Jürgen Butt, George Fytas, Benoit Loppinet
When exposed to weak visible laser light, solutions of common polymers like poly (isoprene) and poly (butadiene) respond by local concentration variations, which in turn lead to refractive index changes. Various micropatterns have been recently reported, depending mostly on the solvent environment and the irradiation conditions. Here, we focused on the simpler case of single polymer-rich filaments and we employed phase contrast microscopy to systematically investigate the influence of laser illumination and material parameters on the kinetics of the optically induced local concentration increase in the polydiene solutions...
June 14, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28601765/application-of-volumetric-absorptive-microsampling-device-for-quantification-of-tacrolimus-in-human-blood-as-a-model-drug-of-high-blood-cell-partition
#6
Kenji Kita, Yuji Mano
Volumetric absorptive microsampling device (VAMS) was evaluated for bioanalysis of tacrolimus, which was used as a model drug with high blood cell partition. Aliquots of blood (ca. 10μL) with different hematocrits and fortified with tacrolimus were wicked up by VAMS and tacrolimus was extracted with a methanol-water mixture (1:1, v/v) via sonication. After chromatography on an AQUITY UPLC HSS T3 column (100×2.1 i.d., mm, 1.8μm), tacrolimus and the internal standard ascomycin, were detected in the positive ion mode with electrospray ionization by monitoring of transitions m/z 826...
June 3, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28596954/assessment-of-health-needs-in-children-with-congenital-upper-limb-differences-in-nicaragua-community-case-study
#7
Maria F Canizares, Jairo J Rios Roque, Gabriel Ramos Zelaya, Michelle A James
Congenital anomalies are prevalent in Nicaragua, and disability is estimated to be 10% in the general population. We studied children with congenital upper limb differences, as they are vulnerable to disability. This case study documents a collaborative effort between American and Nicaraguan orthopedic surgeons to determine unmet health needs of children with congenital upper limb differences at Hospital Manuel de Jesus Rivera ("La Mascota" Hospital) in Nicaragua, with the goal of developing programs that successfully address these needs within the context of the priorities of the community...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28594046/balancing-the-intermolecular-forces-in-peptide-amphiphiles-for-controlling-self-assembly-transitions
#8
C J Buettner, A J Wallace, S Ok, A A Manos, M J Nicholl, A Ghosh, M F Tweedle, J E Goldberger
While the influence of alkyl chain length and headgroup size on self-assembly behaviour has been well-established for simple surfactants, the rational control over the pH- and concentration-dependent self-assembly behaviour in stimuli responsive peptides remains an elusive goal. Here, we show that different amphiphilic peptides can have similar self-assembly phase diagrams, providing the relative strengths of the attractive and repulsive forces are balanced. Using palmitoyl-YYAAEEEEK(DO3A:Gd)-NH2 and palmitoyl-YAAEEEEK(DO3A:Gd)-NH2 as controls, we show that reducing hydrophobic attractive forces through fewer methylene groups in the alkyl chain will lead to a similar self-assembly phase diagram as increasing the electrostatic repulsive forces via the addition of a glutamic acid residue...
June 21, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28592629/immune-related-tumor-response-dynamics-in-melanoma-patients-treated-with-pembrolizumab-identifying-markers-for-clinical-outcome-and-treatment-decisions
#9
Mizuki Nishino, Anita Giobbie-Hurder, Michael P Manos, Nancy Bailey, Elizabeth I Buchbinder, Patrick A Ott, Nikhil H Ramaiya, F Stephen Hodi
Purpose: Characterize tumor burden dynamics during PD-1 inhibitor therapy and investigate the association with overall survival (OS) in advanced melanoma.Experimental Design: The study included 107 advanced melanoma patients treated with pembrolizumab. Tumor burden dynamics were assessed on serial CT scans using irRECIST and were studied for the association with OS.Results: Among 107 patients, 96 patients had measurable tumor burden and 11 had nontarget lesions alone at baseline. In the 96 patients, maximal tumor shrinkage ranged from -100% to 567% (median, -18...
June 7, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28591603/one-dimensional-search-dynamics-of-tumor-suppressor-p53-regulated-by-a-disordered-c-terminal-domain
#10
Agato Murata, Yuji Itoh, Eriko Mano, Saori Kanbayashi, Chihiro Igarashi, Hiroto Takahashi, Satoshi Takahashi, Kiyoto Kamagata
Tumor suppressor p53 slides along DNA and finds its target sequence in drastically different and changing cellular conditions. To elucidate how p53 maintains efficient target search at different concentrations of divalent cations such as Ca(2+) and Mg(2+), we prepared two mutants of p53, each possessing one of its two DNA-binding domains, the CoreTet mutant having the structured core domain plus the tetramerization (Tet) domain, and the TetCT mutant having Tet plus the disordered C-terminal domain. We investigated their equilibrium and kinetic dissociation from DNA and search dynamics along DNA at various [Mg(2+)]...
June 6, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28588797/widespread-subdural-metastasis-from-breast-cancer-progressing-rapidly-with-cerebral-herniation-a-case-report
#11
Yoshiko Okita, Norikazu Masuda, Makiko Mizutani, Yoshinori Kodama, Kiyoshi Mori, Masayuki Mano, Tomoyoshi Nakagawa, Shin Nakajima, Toshiyuki Fujinaka
We herein present the case of a 49-year-old female patient presenting with nausea and headache. The patient's medical history included breast cancer with bone and lymph node metastasis. Computed tomography (CT) examination revealed a high-density lesion in the right subdural space, suggesting hematoma. During surgery planned for subdural hematoma drainage, an en plaque subdural yellowish-white tumor was identified, without hematoma. Histopathological examination revealed metastatic breast cancer. The patient was administered predonisolone and her neurological symptoms gradually recovered...
June 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28586698/multiscale-characterization-of-the-hierarchical-structure-of-dynastes-hercules-elytra
#12
Charles Roux-Pertus, Erwan Oliviero, Véronique Viguier, Frédéric Fernandez, Frédéric Maillot, Olivier Ferry, Solenne Fleutot, João F Mano, Franck Cleymand
Beetle elytra are thickened forewings, they are lightweight and tough to protect the hindwings without hindering flight capacities. Dynastes hercules elytra are known for their hygrochromic properties. However, the whole structure of the elytron remains to be characterized. Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM) and to our knowledge for the first time X-Ray tomography were undertaken on adult male Dynastes hercules to characterize their multi-scale structure. Trabeculae present a periodic arrangement over a short distance...
May 4, 2017: Micron: the International Research and Review Journal for Microscopy
https://www.readbyqxmd.com/read/28579242/mitochonic-acid-5-ma-5-facilitates-atp-synthase-oligomerization-and-cell-survival-in-various-mitochondrial-diseases
#13
Tetsuro Matsuhashi, Takeya Sato, Shin-Ichiro Kanno, Takehiro Suzuki, Akihiro Matsuo, Yuki Oba, Motoi Kikusato, Emi Ogasawara, Tai Kudo, Kosuke Suzuki, Osamu Ohara, Hiroko Shimbo, Fumika Nanto, Hiroaki Yamaguchi, Daisuke Saigusa, Yasuno Mukaiyama, Akiko Watabe, Koichi Kikuchi, Hisato Shima, Eikan Mishima, Yasutoshi Akiyama, Yoshitsugu Oikawa, H O Hsin-Jung, Yukako Akiyama, Chitose Suzuki, Mitsugu Uematsu, Masaki Ogata, Naonori Kumagai, Masaaki Toyomizu, Atsushi Hozawa, Nariyasu Mano, Yuji Owada, Setsuya Aiba, Teruyuki Yanagisawa, Yoshihisa Tomioka, Shigeo Kure, Sadayoshi Ito, Kazuto Nakada, Ken-Ichiro Hayashi, Hitoshi Osaka, Takaaki Abe
Mitochondrial dysfunction increases oxidative stress and depletes ATP in a variety of disorders. Several antioxidant therapies and drugs affecting mitochondrial biogenesis are undergoing investigation, although not all of them have demonstrated favorable effects in the clinic. We recently reported a therapeutic mitochondrial drug mitochonic acid MA-5 (Tohoku J. Exp. Med., 2015). MA-5 increased ATP, rescued mitochondrial disease fibroblasts and prolonged the life span of the disease model "Mitomouse" (JASN, 2016)...
May 13, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28577930/lower-urinary-tract-symptoms-and-benign-prostate-hyperpasia-features-among-male-brca-mutation-carriers
#14
Hanan Goldberg, Liat Shavit Grievink, Roy Mano, Yeara Bar, Rachely Ozalbo, Sivan Tuval, Jack Baniel, David Margel
OBJECTIVE: To analyze lower urinary tract symptoms (LUTS) and benign prostate hyperplasia (BPH) features among male BRCA 1 and 2 carriers and an age matched control group. PATIENTS AND METHODS: Male BRCA carriers and non-carriers aged 40-70 were enrolled in our cross sectional study. Relevant clinical data was collected and patients filled the international prostate symptoms questionnaire. Patients also underwent PSA blood testing, digital rectal examination, uroflowmetry and post void residual (PVR) ultrasound examination...
May 31, 2017: Urology
https://www.readbyqxmd.com/read/28577751/association-between-local-bipolar-voltage-and-conduction-gap-along-the-left-atrial-linear-ablation-lesion-in-patients-with-atrial-fibrillation
#15
Masaharu Masuda, Masashi Fujita, Osamu Iida, Shin Okamoto, Takayuki Ishihara, Kiyonori Nanto, Takashi Kanda, Akihiro Sunaga, Takuya Tsujimura, Yasuhiro Matsuda, Toshiaki Mano
A bipolar voltage reflects a thick musculature where formation of a transmural lesion may be hard to achieve. The purpose of this study was to explore the association between local bipolar voltage and conduction gap in patients with persistent atrial fibrillation (AF) who underwent atrial roof or septal linear ablation. This prospective observational study included 42 and 36 consecutive patients with persistent AF who underwent roof or septal linear ablations, respectively. After pulmonary vein isolation, left atrial linear ablations were performed, and conduction gap sites were identified and ablated after first-touch radiofrequency application...
May 10, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28577441/exploring-disparities-in-incidence-and-mortality-rates-of-breast-and-gynecologic-cancers-according-to-the-human-development-index-in-the-pan-american-region
#16
J Martínez-Mesa, G Werutsky, S Michiels, C A S Pereira Filho, A Dueñas-González, J J Zarba, M Mano, C Villarreal-Garza, H Gómez, C H Barrios
OBJECTIVE: To evaluate whether a country's Human Development Index (HDI) can help explain the differences in the country's breast cancer and gynecological cancer incidence and mortality rates in the Pan-American region. STUDY DESIGN: Ecological analysis. METHODS: Pan-American region countries with publicly available data both in GLOBOCAN 2012 and the United Nations Development Report 2012 were included (n = 28). Incidence and mortality rates age-standardized per 100,000 were natural log-transformed for breast cancer, ovarian cancer, corpus uteri cancer, and cervical cancer...
June 1, 2017: Public Health
https://www.readbyqxmd.com/read/28576050/extraction-and-characterization-of-collagen-from-antarctic-and-sub-antarctic-squid-and-its-potential-application-in-hybrid-scaffolds-for-tissue-engineering
#17
Rui C G Coelho, Ana L P Marques, Sara M Oliveira, Gabriela S Diogo, Rogério P Pirraco, Joana Moreira-Silva, José C Xavier, Rui L Reis, Tiago H Silva, João F Mano
Collagen is the most abundant protein found in mammals and it exhibits a low immunogenicity, high biocompatibility and biodegradability when compared with others natural polymers. For this reason, it has been explored for the development of biologically instructive biomaterials with applications for tissue substitution and regeneration. Marine origin collagen has been pursued as an alternative to the more common bovine and porcine origins. This study focused on squid (Teuthoidea: Cephalopoda), particularly the Antarctic squid Kondakovia longimana and the Sub-Antarctic squid Illex argentinus as potential collagen sources...
September 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28573749/obesity-impedes-functional-improvement-in-youth-with-chronic-pain-an-initial-investigation
#18
A M Stoner, K E Jastrowski Mano, S J Weisman, K R Hainsworth
BACKGROUND: Youth with chronic pain are at higher risk for obesity than the general population. In youth with chronic pain, obesity exacerbates pain-specific activity limitations, and in adults with chronic pain, obesity perpetuates a cycle of disability. The current study examined whether weight status predicts functional disability outcomes over time in youth with chronic pain. METHODS: Data were obtained from a retrospective chart review of patients who consented to participate in a longitudinal outcomes study...
June 2, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28570975/nutrient-dynamics-and-eutrophication-in-the-sea-of-marmara-data-from-recent-oceanographic-research
#19
Bahattin Yalçın, M Levent Artüz, Alexandra Pavlidou, Soner Çubuk, Manos Dassenakis
This work was implemented to study the physicochemical and biological characteristics of the Sea of Marmara and the Turkish straits (TSS: Bosporus and Dardanelles straits) for the period 2010-2013 and to calculate winter and summer fluxes of nutrients (nitrates, phosphates) between the Aegean and Black Seas through the TSS. The brackish Black Sea waters reach the Dardanelles Strait with modified biochemical properties. The salinity and phosphates of the surface waters increased westwards. Biologically labile nutrients of Black Sea origin are utilized through biological processes in the Marmara Sea...
May 29, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28570424/adherence-to-hepatitis-b-antiviral-therapy-a-qualitative-study
#20
Suzanne Polis, Iryna Zablotska-Manos, Amany Zekry, Lisa Maher
Hepatitis B virus (HBV) antiviral therapies potentially suppress HBV viral load to an undetectable level reducing the risk of progressive liver disease and the development of HBV-related hepatocellular carcinoma. Adherence to antiviral therapies is imperative to achieve and maintain viral suppression. To date, there has been limited research on adherence to HBV therapies. Our study aimed to explore factors influencing adherence to antiviral therapy. A total of 29 participants consented to in-depth qualitative interviews at three outpatient clinics in Sydney, New South Wales, Australia...
May 2017: Gastroenterology Nursing: the Official Journal of the Society of Gastroenterology Nurses and Associates
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