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https://www.readbyqxmd.com/read/28727934/phylogenomics-reveals-a-complex-evolutionary-history-of-lobed-leaf-white-oaks-in-western-north-america
#1
John D McVay, Duncan Hauser, Andrew L Hipp, Paul Manos
Quercus (oak) species hybridize in complex patterns that have yet to be fully explored with phylogenomic data. Analyses to date have recovered reasonable divergent patterns, suggesting that the impact of introgression may not always be obvious in inferred oak phylogenies. We explore this phenomenon using RADseq data for 136 samples representing 54 oak species by conducting phylogenetic analyses designed to distinguish signals of lineage diversification and hybridization, focusing on the lobed-leaf species Quercus gambelii, Q...
July 20, 2017: Genome Génome / Conseil National de Recherches Canada
https://www.readbyqxmd.com/read/28718362/adaptive-behaviour-and-motor-skills-in-children-with-upper-limb-deficiency
#2
Hiroshi Mano, Sayaka Fujiwara, Nobuhiko Haga
BACKGROUND: The dysfunction of individuals with upper limb deficiencies affects their daily lives and social participation. OBJECTIVES: To clarify the adaptive behaviours and motor skills of children with upper limb deficiencies. STUDY DESIGN: Cross-sectional survey. METHODS: The subjects were 10 children ranging from 1 to 6 years of age with unilateral upper limb deficiencies at the level distal to the elbow who were using only cosmetic or passive prostheses or none at all...
July 1, 2017: Prosthetics and Orthotics International
https://www.readbyqxmd.com/read/28712661/managing-incidentalomas-safely-do-computed-tomography-requisitions-tell-us-what-we-need-to-know
#3
Matthew Walker, Joy Borgaonkar, Daria Manos
PURPOSE: Technological advancements and the ever-increasing use of computed tomography (CT) have greatly increased the detection of incidental findings, including tiny pulmonary nodules. The management of many "incidentalomas" is significantly influenced by a patient's history of cancer. The study aim is to determine if CT requisitions include prior history of malignancy. METHODS: Requisitions for chest CTs performed at our adult tertiary care hospital during April 2012 were compared to a cancer history questionnaire, administered to patients at the time of CT scan...
July 13, 2017: Canadian Association of Radiologists Journal, Journal L'Association Canadienne des Radiologistes
https://www.readbyqxmd.com/read/28705423/carbon-nanotube-fiber-mats-for-microbial-fuel-cell-electrodes
#4
Brigitte Delord, Wilfrid Neri, Karen Bertaux, Alain Derre, Isabelle Ly, Nicolas Mano, Philippe Poulin
Novel carbon nanotube based electrodes of microbial fuel cells (MFC) have been developed. MFC is a promising technology for the wastewater treatment and the production of electrical energy from redox reactions of natural substrates. Performances of such bio-electrochemical systems depend critically on the structure and properties of the electrodes. The presently developed materials are made by weaving fibers solely comprised of carbon nanotubes. They exhibit a large scale porosity controlled by the weaving process...
July 1, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28701543/novel-channel-mediated-choline-transport-in-cholinergic-neurons-of-the-mouse-retina
#5
Toshiyuki Ishii, Kohei Homma, Asuka Mano, Takumi Akagi, Yasuhide Shigematsu, Yukio Shimoda, Hiroyoshi Inoue, Yoshihiko Kakinuma, Makoto Kaneda
Choline uptake into the presynaptic terminal of cholinergic neurons is mediated by the high affinity choline transporter and is essential for acetylcholine synthesis. In a previous study, we reported that P2X2 purinoceptors are selectively expressed in OFF-cholinergic amacrine cells of the mouse retina. Under specific conditions, P2X2 purinoceptors acquire permeability to large cations, such as N-methyl-D-glucamine, and therefore potentially could act as a non-canonical pathway for choline entry into neurons...
July 12, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28700235/quantitative-crassphage-pcr-assays-for-human-fecal-pollution-measurement
#6
Elyse Stachler, Catherine Kelty, Mano Sivaganesan, Xiang Li, Kyle Bibby, Orin C Shanks
Environmental waters are monitored for fecal pollution to protect public health and water resources. Traditionally, general fecal indicator bacteria are used; however, they cannot distinguish human fecal waste from other animal pollution sources. Recently, a novel bacteriophage, crAssphage, was discovered by metagenomic data mining and reported to be abundant in and closely associated with human fecal waste. To confirm bioinformatic predictions, 384 primer sets were designed along the length of the crAssphage genome...
July 12, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28689738/unconjugated-bile-acids-in-rat-brain-analytical-method-based-on-lc-esi-ms-ms-with-chemical-derivatization-and-estimation-of-their-origin-by-comparison-to-serum-levels
#7
Tatsuya Higashi, Shui Watanabe, Koki Tomaru, Wataru Yamazaki, Kazumi Yoshizawa, Shoujiro Ogawa, Hidenori Nagao, Kouichi Minato, Masamitsu Maekawa, Nariyasu Mano
Although some studies have revealed the implication of bile acids (BAs) and neurological diseases, the levels and origin of the BAs in the brain are not fully understood. In this study, we first developed and validated a sensitive and specific method for the determination of three unconjugated BAs [cholic acid (CA), chenodeoxycholic acid (CDCA) and deoxycholic acid (DCA)] in the rat brain by liquid chromatography/electrospray ionization-tandem mass spectrometry combined with chemical derivatization. The measured brain concentrations (mean ± standard deviation, n = 10) of normal rats were 58...
July 6, 2017: Steroids
https://www.readbyqxmd.com/read/28689481/histological-evaluation-of-a-self-expanding-stent-graft-23-months-after-implantation-in-the-superficial-femoral-artery
#8
Takayuki Ishihara, Osamu Iida, Katsumi Inoue, Masashi Fujita, Masaharu Masuda, Shin Okamoto, Kiyonori Nanto, Takashi Kanda, Takuya Tsujimura, Akihiro Sunaga, Toshiaki Mano, Masaaki Uematsu
PURPOSE: To report histological examination of a Viabahn stent-graft implanted in the superficial femoral artery (SFA) for nearly 2 years. CASE REPORT: A 78-year-old man with peripheral artery disease was treated successfully with a 6.0×250-mm Viabahn self-expanding stent-graft in the right SFA, relieving his lower limb claudication. The patient died suddenly due to acute myocardial infarction 23 months later. Histological evaluation of the stent-graft implantation site revealed moderate neointimal proliferation at both proximal and distal edges of the device...
July 1, 2017: Journal of Endovascular Therapy
https://www.readbyqxmd.com/read/28677170/inactivating-mutations-and-hypermethylation-of-the-nkx2-1-ttf-1-gene-in-non-tru-type-lung-adenocarcinomas
#9
Daisuke Matsubara, Manabu Soda, Taichiro Yoshimoto, Yusuke Amano, Yuji Sakuma, Azusa Yamato, Toshihide Ueno, Shinya Kojima, Tomoki Shibano, Yasuyuki Hosono, Masahito Kawazu, Yoshihiro Yamashita, Shunsuke Endo, Koichi Hagiwara, Masashi Fukayama, Takashi Takahashi, Hiroyuki Mano, Toshiro Niki
The major driver mutations of lung cancer, the EGFR mutations and EML4-ALK fusion, are mainly detected in terminal respiratory unit (TRU)-type lung adenocarcinomas, which typically show lepidic and/or papillary patterns, but are rarely associated with a solid or invasive mucinous morphology. In order to elucidate the key genetic events in non-TRU-type lung cancer, we conducted whole-exome sequencing on 43 non-TRU-type lung adenocarcinomas based on morphology (17 acinar, 9 solid, 2 enteric adenocarcinomas, and 15 adenocarcinomas with a mucinous morphology)...
July 5, 2017: Cancer Science
https://www.readbyqxmd.com/read/28676214/dna-mismatch-repair-deficiency-in-surgically-resected-lung-adenocarcinoma-microsatellite-instability-analysis-using-the-promega-panel
#10
Kazuya Takamochi, Fumiyuki Takahashi, Yoshiyuki Suehara, Eiichi Sato, Shinji Kohsaka, Takuo Hayashi, Shigehisa Kitano, Toshihide Uneno, Shinya Kojima, Kengo Takeuchi, Hiroyuki Mano, Kenji Suzuki
OBJECTIVES: DNA mismatch repair (MMR) deficiency has recently received increasing attention as a significant biomarker to predict the treatment effect of immune checkpoint inhibitors for various malignant neoplasms. To evaluate MMR status, we analyzed the microsatellite instability (MSI) of lung adenocarcinomas. MATERIALS AND METHODS: Frozen tissues of lung adenocarcinoma and corresponding normal lung were obtained from 341 patients, including 141 with tumors harboring driver gene alterations (50 EGFR gene mutations, 50 KRAS gene mutations, 21 ALK fusions, 10 ROS1 fusions, and 10 RET fusions) and 200 with pan-negative tumors (100 never- or light-smokers and 100 heavy-smokers), who were surgically treated between 2007 and 2015...
August 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28672263/functionalizing-soy-protein-nano-aggregates-with-ph-shifting-and-mano-thermo-sonication
#11
Gulcin Yildiz, Juan Andrade, Nicki E Engeseth, Hao Feng
Plant protein-mediated nano-delivery systems have gained increasing attention in the food and pharmaceutical industries in recent years. Several physical and chemical methods for improving the functional properties of plant proteins with respect to the native forms have been proposed. This study presents a new approach, which combines pH-shifting and mano-thermo-sonication (MTS) to produce soy protein nano-aggregates with significantly improved functional properties. Soy-protein isolate (SPI) was treated with pH-shifting at pH 12 or in combination with MTS and high-pressure homogenization (HPH)...
June 27, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28671687/recurrent-spi1-pu-1-fusions-in-high-risk-pediatric-t-cell-acute-lymphoblastic-leukemia
#12
Masafumi Seki, Shunsuke Kimura, Tomoya Isobe, Kenichi Yoshida, Hiroo Ueno, Yaeko Nakajima-Takagi, Changshan Wang, Lin Lin, Ayana Kon, Hiromichi Suzuki, Yusuke Shiozawa, Keisuke Kataoka, Yoichi Fujii, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Teppei Shimamura, Kyoko Masuda, Hiroshi Kawamoto, Kentaro Ohki, Motohiro Kato, Yuki Arakawa, Katsuyoshi Koh, Ryoji Hanada, Hiroshi Moritake, Masaharu Akiyama, Ryoji Kobayashi, Takao Deguchi, Yoshiko Hashii, Toshihiko Imamura, Atsushi Sato, Nobutaka Kiyokawa, Akira Oka, Yasuhide Hayashi, Masatoshi Takagi, Atsushi Manabe, Akira Ohara, Keizo Horibe, Masashi Sanada, Atsushi Iwama, Hiroyuki Mano, Satoru Miyano, Seishi Ogawa, Junko Takita
The outcome of treatment-refractory and/or relapsed pediatric T cell acute lymphoblastic leukemia (T-ALL) is extremely poor, and the genetic basis for this is not well understood. Here we report comprehensive profiling of 121 cases of pediatric T-ALL using transcriptome and/or targeted capture sequencing, through which we identified new recurrent gene fusions involving SPI1 (STMN1-SPI1 and TCF7-SPI1). Cases positive for fusions involving SPI1 (encoding PU.1), accounting for 3.9% (7/181) of the examined pediatric T-ALL cases, showed a double-negative (DN; CD4(-)CD8(-)) or CD8(+) single-positive (SP) phenotype and had uniformly poor overall survival...
July 3, 2017: Nature Genetics
https://www.readbyqxmd.com/read/28666280/amyloid-%C3%AE-1-43-accumulates-in-the-lens-epithelium-of-cortical-opacification-in-japanese-patients
#13
Noriaki Nagai, Yu Mano, Hiroko Otake, Teppei Shibata, Eri Kubo, Hiroshi Sasaki
Purpose: We investigated the accumulation of amyloid β (Aβ1-40, Aβ1-42, Aβ1-43) in the lens epithelium of patients with opacification of five different types (cortical cataract [COR]; nuclear cataract [NUC]; posterior subcapsular cataract [PSC]; retrodots [RD]; and water clefts [WC]). Methods: Samples were collected from Japanese patients taken during cataract surgery; Aβ levels and mRNA expression were determined by ELISA and a real-time RT-PCR method, respectively...
June 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28664375/human-sperm-dna-damage-inhibition-and-antioxidant-activity-of-t-arjuna-bark-an-in-vitro-study
#14
Parameswari R, Kamini A Rao, K Mano, M Aruna, A S Vickram, M Rameshpathy, T B Sridharan
Complimentary or natural antioxidant type of alternative medicine is developed worldwide to treat male infertility. The aim of this study is to the extraction of T. arjuna bark and activity against human sperm DNA damage in asthenoteratospermic smoker's subjects-an in vitro study. All preliminary and antioxidant assays (DPPH, H2O2, and total antioxidant, reducing power activity) were done. T. arjuna bark metal analysis was done with AAS. On the other hand, patients were asked to fill a direct questionnaire about smoking history; 25 infertile smokers were identified as asthenoteratospermic; 34 fertile non-smokers (control) were assessed for semen parameters by CASA, seminal plasma Zinc analysis by AAS, DNA fragmentation by colorimetric method and semen genomic DNA damage inhibition by modified non-enzymatic salting out extraction method...
July 2017: 3 Biotech
https://www.readbyqxmd.com/read/28655431/canadian-association-of-radiologists-guide-on-computed-tomography-screening-for-lung-cancer
#15
REVIEW
Jana Taylor, Daria Manos, Heidi Schmidt, Marie-Hélène Lévesque, Micheal C McInnis
No abstract text is available yet for this article.
August 2017: Canadian Association of Radiologists Journal, Journal L'Association Canadienne des Radiologistes
https://www.readbyqxmd.com/read/28654276/mercouri-g-kanatzidis-excellence-and-innovations-in-inorganic-and-solid-state-chemistry
#16
Indika U Arachchige, Gerasimos S Armatas, Kanishka Biswas, Kota S Subrahmanyam, Susan Latturner, Christos D Malliakas, Manolis J Manos, Youngtak Oh, Kyriaki Polychronopoulou, Pierre F P Poudeu, Pantelis N Trikalitis, Qichun Zhang, Li-Dong Zhao, Sebastian C Peter
Over the last 3-4 decades, solid-state chemistry has emerged as the forefront of materials design and development. The field has revolutionized into a multidisciplinary subject and matured with a scope of new synthetic strategies, new challenges, and opportunities. Understanding the structure is very crucial in the design of appropriate materials for desired applications. Professor Mercouri G. Kanatzidis has encountered both challenges and opportunities during the course of the discovery of many novel materials...
July 17, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28649576/you-fill-my-heart-looking-at-one-s-partner-increases-interoceptive-accuracy
#17
Lara Maister, Lilla Hodossy, Manos Tsakiris
The integration of external and internal bodily signals provides a coherent, multisensory experience of one's own body. The ability to accurately detect internal bodily sensations is referred to as interoceptive accuracy (IAcc). Previous studies found that IAcc can be increased when people with low IAcc engage in self-processing such as when looking in the mirror or at a photograph of one's own face. However, the way the self is represented changes depending on the context. Specifically, in social situations, the self is experienced in relation to significant others and not as an isolated individual...
June 2017: Psychology of Consciousness: Theory, Research, and Practice
https://www.readbyqxmd.com/read/28643179/erratum-to-various-regulatory-modes-for-circadian-rhythmicity-and-sexual-dimorphism-in-the-non-neuronal-cardiac-cholinergic-system
#18
Shino Oikawa, Yuko Kai, Asuka Mano, Hisayuki Ohata, Takahiro Nemoto, Yoshihiko Kakinuma
No abstract text is available yet for this article.
June 22, 2017: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/28642038/functional-characterization-of-21-allelic-variants-of-dihydropyrimidinase
#19
Eiji Hishinuma, Fumika Akai, Yoko Narita, Masamitsu Maekawa, Hiroaki Yamaguchi, Nariyasu Mano, Akifumi Oda, Noriyasu Hirasawa, Masahiro Hiratsuka
Dihydropyrimidinase (DHP, EC 3.5.2.2), encoded by the gene DPYS, is the second enzyme in the catabolic pathway of pyrimidine and of fluoropyrimidine drugs such as 5-fluorouracil, which are commonly used in anticancer treatment; DHP catalyzes the hydrolytic ring opening of dihydrouracil and dihydro-5-fluorouracil. DPYS mutations are known to contribute to interindividual variations in the toxicity of fluoropyrimidine drugs, but the functional characterization of DHP allelic variants remains inadequate. In this study, in vitro analysis was performed on 22 allelic variants of DHP by transiently expressing wild-type DHP and 21 DHP variants in 293FT cells and characterizing their enzymatic activities by using dihydrouracil and dihydro-5-fluorouracil as substrates...
June 19, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28636652/integrative-analysis-of-genomic-alterations-in-triple-negative-breast-cancer-in-association-with-homologous-recombination-deficiency
#20
Masahito Kawazu, Shinya Kojima, Toshihide Ueno, Yasushi Totoki, Hiromi Nakamura, Akiko Kunita, Wei Qu, Jun Yoshimura, Manabu Soda, Takahiko Yasuda, Natsuko Hama, Mihoko Saito-Adachi, Kazuhito Sato, Shinji Kohsaka, Eirin Sai, Masako Ikemura, Shigeru Yamamoto, Tomoko Ogawa, Masashi Fukayama, Keiichiro Tada, Yasuyuki Seto, Shinichi Morishita, Shoichi Hazama, Tatsuhiro Shibata, Yoshihiro Yamashita, Hiroyuki Mano
Triple-negative breast cancer (TNBC) cells do not express estrogen receptors, progesterone receptors, or human epidermal growth factor receptor 2. Currently, apart from poly ADP-ribose polymerase inhibitors, there are few effective therapeutic options for this type of cancer. Here, we present comprehensive characterization of the genetic alterations in TNBC performed by high coverage whole genome sequencing together with transcriptome and whole exome sequencing. Silencing of the BRCA1 gene impaired the homologous recombination pathway in a subset of TNBCs, which exhibited similar phenotypes to tumors with BRCA1 mutations; they harbored many structural variations (SVs) with relative enrichment for tandem duplication...
June 2017: PLoS Genetics
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