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https://www.readbyqxmd.com/read/28433622/diminished-capacity-of-opsonization-and-immune-complex-solubilization-and-detection-of-anti-c1q-antibodies-in-sera-from-patients-with-hereditary-angioedema
#1
Daisuke Honda, Isao Ohsawa, Nobuyuki Sato, Hiroyuki Inoshita, Satoshi Mano, Yasuhiko Tomino, Yusuke Suzuki
BACKGROUND: Hereditary angioedema (HAE) is an autosomal dominant disease caused by deficiency of C1 esterase inhibitor. Symptoms of HAE include edema, which can potentially cause suffocation. Some patients with HAE exhibit immunological abnormalities, which could prevent an accurate diagnosis. Low levels of complement components are characteristic of HAE and in other settings are thought to reduce elimination of apoptotic cells and immune complex (IC). Thus, we aimed to experimentally clarify the mechanism of immunological abnormalities using sera from HAE patients...
April 19, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28432686/high-level-of-reduced-glutathione-contributes-to-detoxification-of-lipid-peroxide-derived-reactive-carbonyl-species-in-transgenic-arabidopsis-overexpressing-glutathione-reductase-under-aluminum-stress
#2
Lina Yin, Jun'ichi Mano, Kiyoshi Tanaka, Shiwen Wang, Meijuan Zhang, Xiping Deng, Suiqi Zhang
Lipid peroxide-derived reactive carbonyl species (RCS), generated downstream of reactive oxygen species (ROS), are critical damage-inducing species in plant aluminum (Al) toxicity. In mammals, RCS are scavenged primarily by glutathione (GSH), but in plant Al stress, contribution of GSH to RCS detoxification has not been evaluated. In this study, Arabidopsis plants overexpressing the gene AtGR1 (accession code At3g24170), encoding glutathione reductase (GR), were generated, and their performance under Al stress was examined...
April 21, 2017: Physiologia Plantarum
https://www.readbyqxmd.com/read/28427762/multidisciplinary-management-of-head-and-neck-cancer-first-expert-consensus-using-delphi-methodology-from-the-spanish-society-for-head-and-neck-cancer-part-2
#3
REVIEW
A Rueda, J Giralt, M Mañós, A Lozano, A Sistiaga, E García-Miragall, J Cacicedo, F Esteban, B Scola, J Contreras, A Ruiz, A Carral, G González-Aniceto, M Pastor, J J Herranz, M Bernal, R Mesía
Head and neck cancer is one of the most frequent malignances worldwide. Despite the site-specific multimodality therapy, up to half of the patients will develop recurrence. Treatment selection based on a multidisciplinary tumor board represents the cornerstone of head and neck cancer, as it is essential for achieving the best results, not only in terms of outcome, but also in terms of organ-function preservation and quality of life. Evidence-based international and national clinical practice guidelines for head and neck cancer not always provide answers in terms of decision-making that specialists have to deal with in their daily practice...
April 17, 2017: Oral Oncology
https://www.readbyqxmd.com/read/28427761/multidisciplinary-management-of-head-and-neck-cancer-first-expert-consensus-using-delphi-methodology-from-the-spanish-society-for-head-and-neck-cancer-part-1
#4
REVIEW
M Mañós, J Giralt, A Rueda, J Cabrera, J Martinez-Trufero, J Marruecos, A Lopez-Pousa, J P Rodrigo, B Castelo, J Martínez-Galán, F Arias, M Chaves, J J Herranz, V Arrazubi, N Baste, A Castro, R Mesía
Head and neck cancer is one of the most frequent malignances worldwide. Despite the site-specific multimodality therapy, up to half of the patients will develop recurrence. Treatment selection based on a multidisciplinary tumor board represents the cornerstone of head and neck cancer, as it is essential for achieving the best results, not only in terms of outcome, but also in terms of organ-function preservation and quality of life. Evidence-based international and national clinical practice guidelines for head and neck cancer not always provide answers in terms of decision-making that specialists must deal with in their daily practice...
April 17, 2017: Oral Oncology
https://www.readbyqxmd.com/read/28420589/associations-between-language-acculturation-age-of-immigration-and-obesity-in-the-mexican-american-mano-a-mano-cohort
#5
Matthew Chrisman, Wong-Ho Chow, Carrie R Daniel, Xifeng Wu, Hua Zhao
INTRODUCTION: As Mexican immigrants to the U.S. become acculturated, they face worsening health outcomes such as obesity. The role of language acculturation in the development of obesity has not been thoroughly examined. METHODS: To examine associations between language acculturation and obesity, data were drawn from the Mexican-American Mano A Mano cohort study. Participants aged 20 years and over (n=18,298) completed baseline questionnaires on socio-demographic and behavioural factors, including physical activity and sitting time...
April 15, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28409157/ferulic-acid-suppresses-amyloid-%C3%AE-production-in-the-human-lens-epithelial-cell-stimulated-with-hydrogen-peroxide
#6
Noriaki Nagai, Sachiyo Kotani, Yu Mano, Akina Ueno, Yoshimasa Ito, Toshio Kitaba, Takumi Takata, Noriko Fujii
It is well known that oxidative stresses induce the production of amyloid β (Aβ) in the brain, lens, and retina, leading to age-related diseases. In the present study, we investigated the effects of ferulic acid on the Aβ levels in H2O2-stimulated human lens epithelial (HLE) SRA 01/04 cells. Three types of Aβ peptides (Aβ1-40, Aβ1-42, and Aβ1-43) were measured by ELISA, and the levels of mRNA for the expressed proteins related to Aβ production (APP, BACE1, and PS proteins) and degradation (ADAM10, NEP, and ECE1 proteins) were determined by quantitative real-time RT-PCR...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28407758/school-grade-and-sex-differences-in-domain-specific-sedentary-behaviors-among-japanese-elementary-school-children-a-cross-sectional-study
#7
Kaori Ishii, Ai Shibata, Minoru Adachi, Yoshiyuki Mano, Koichiro Oka
BACKGROUND: It is vital to reduce the proportion of sedentary behavior in children. Understanding the duration and behavioral context is needed. The present study examined school-grade and sex differences in domain-specific sedentary times and concurrence with screen-time guidelines among Japanese elementary school children. METHODS: A total of 625 children (330 boys) were surveyed in 2010 and 2014. Using a questionnaire, data regarding participants' grade (first through third grades: lower grades; fourth through six grades: higher grades), sex, weight, and height were collected in addition to the time spent per day engaging in each specific sedentary behavior separately: (1) reading or listening to music, (2) TV or video viewing, (3) TV game use, (4) internet use excluding class, (5) homework, and (6) car travel...
April 13, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28399435/inhibition-of-crm1-mediated-nuclear-export-of-influenza-a-nucleoprotein-and-nuclear-export-protein-as-a-novel-target-for-antiviral-drug-development
#8
Nopporn Chutiwitoonchai, Takafumi Mano, Michinori Kakisaka, Hirotaka Sato, Yasumitsu Kondoh, Hiroyuki Osada, Osamu Kotani, Masaru Yokoyama, Hironori Sato, Yoko Aida
An anti-influenza compound, DP2392-E10 based on inhibition of the nuclear export function of the viral nucleoprotein-nuclear export signal 3 (NP-NES3) domain was successfully identified by our previous high-throughput screening system. Here, we demonstrated that DP2392-E10 exerts its antiviral effect by inhibiting replication of a broad range of influenza A subtypes. In regard to the molecular mechanism, we revealed that DP2392-E10 inhibits nuclear export of both viral NP and nuclear export protein (NEP). More specifically, in vitro pull-down assays revealed that DP2392-E10 directly binds cellular CRM1, which mediates nuclear export of NP and NEP...
April 8, 2017: Virology
https://www.readbyqxmd.com/read/28394930/analysis-of-host-microrna-function-uncovers-a-role-for-mir-29b-2-5p-in-shigella-capture-by-filopodia
#9
Ushasree Sunkavalli, Carmen Aguilar, Ricardo Jorge Silva, Malvika Sharan, Ana Rita Cruz, Caroline Tawk, Claire Maudet, Miguel Mano, Ana Eulalio
MicroRNAs play an important role in the interplay between bacterial pathogens and host cells, participating as host defense mechanisms, as well as exploited by bacteria to subvert host cellular functions. Here, we show that microRNAs modulate infection by Shigella flexneri, a major causative agent of bacillary dysentery in humans. Specifically, we characterize the dual regulatory role of miR-29b-2-5p during infection, showing that this microRNA strongly favors Shigella infection by promoting both bacterial binding to host cells and intracellular replication...
April 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28389263/post-ritual-circumcision-bleeding-characteristics-and-treatment-outcome
#10
Roy Mano, Amihay Nevo, Bezalel Sivan, Roy Morag, David Ben-Meir
OBJECTIVE: To report the characteristics, treatment, and short term outcome of neonatal post-circumcision bleeding, and identify predictors of surgical treatment. METHODS: The medical records of 90 consecutive neonates who presented to the emergency room with post-circumcision bleeding between 2009 and 2014 were reviewed. Circumcisions were performed using the traditional Mogen shield device. The study endpoint was surgical intervention for hemostasis. Predictors of surgical treatment were evaluated...
April 4, 2017: Urology
https://www.readbyqxmd.com/read/28385413/what-does-the-in-pact-sfa-long-study-tell-us
#11
EDITORIAL
Osamu Iida, Mitsuyoshi Takahara, Toshiaki Mano
No abstract text is available yet for this article.
April 10, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28384612/a-review-on-thermal-and-catalytic-pyrolysis-of-plastic-solid-waste-psw
#12
REVIEW
S M Al-Salem, A Antelava, A Constantinou, G Manos, A Dutta
Plastic plays an important role in our daily lives due to its versatility, light weight and low production cost. Plastics became essential in many sectors such as construction, medical, engineering applications, automotive, aerospace, etc. In addition, economic growth and development also increased our demand and dependency on plastics which leads to its accumulation in landfills imposing risk on human health, animals and cause environmental pollution problems such as ground water contamination, sanitary related issues, etc...
April 3, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28378080/cost-analysis-of-leak-after-sleeve-gastrectomy
#13
Marius Nedelcu, Thierry Manos, Michel Gagner, Imane Eddbali, Ahmed Ahmed, Patrick Noel
BACKGROUND: Leaks after laparoscopic sleeve gastrectomy (LSG) are serious complications of this procedure. The objective of the present study was to evaluate the costs of leaks after LSG. SETTING: Private hospital, France. METHODS: A retrospective analysis was conducted on a prospective cohort of 2012 cases of LSG between September 2005 and December 2014. Data were collected on all diagnostic and therapeutic measures necessary to manage leaks, ward, and intensive care unit (ICU) length of stay...
April 4, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28377691/how-to-build-a-hybrid-neurofeedback-platform-combining-eeg-and-fmri
#14
Marsel Mano, Anatole Lécuyer, Elise Bannier, Lorraine Perronnet, Saman Noorzadeh, Christian Barillot
Multimodal neurofeedback estimates brain activity using information acquired with more than one neurosignal measurement technology. In this paper we describe how to set up and use a hybrid platform based on simultaneous electroencephalography (EEG) and functional magnetic resonance imaging (fMRI), then we illustrate how to use it for conducting bimodal neurofeedback experiments. The paper is intended for those willing to build a multimodal neurofeedback system, to guide them through the different steps of the design, setup, and experimental applications, and help them choose a suitable hardware and software configuration...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28377099/from-the-body-s-viscera-to-the-body-s-image-is-there-a-link-between-interoception-and-body-image-concerns
#15
REVIEW
Deborah Badoud, Manos Tsakiris
Interoception, the sense of the physiological condition of the body originating from within its internal organs, and body image, namely the perception, feelings and attitudes one has about one's body, are two fundamental components of our sense of personal identity and overall well-being. However, the relation between interoception and body image remains poorly understood. We here review recent behavioural and neuroimaging evidence from non-clinical and clinical populations (e.g. eating disorders) to propose that basic interoceptive processes and interoceptive awareness may crucially contribute to the complex formation of body image, as well as to its disturbances...
April 1, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28373103/dermal-absorption-behavior-of-fluorescent-molecules-in-nanoparticles-on-human-and-porcine-skin-models
#16
Nir Debotton, Amit Badihi, Mano Robinpour, Claes D Enk, Simon Benita
The percutaneous passage of poorly skin absorbed molecules can be improved using nanocarriers, particularly biodegradable polymeric nanospheres (NSs) or nanocapsules (NCs). However, penetration of the encapsulated molecules may be affected by other factors than the nanocarrier properties. To gain insight information on the skin absorption of two fluorescent cargos, DiIC18(5) and coumarin-6 were incorporated in NSs or NCs and topically applied on various human and porcine skin samples. 3D imaging techniques suggest that NSs and NCs enhanced deep dermal penetration of both probes similarly, when applied on excised human skin irrespective of the nature of the cargo...
April 2, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28371516/control-of-cell-alignment-and-morphology-by-redesigning-ecm-mimetic-nanotopography-on-multilayer-membranes
#17
Maria P Sousa, Sofia G Caridade, João F Mano
Inspired by native extracellular matrix (ECM) together with the multilevel architecture observed in nature, a material which topography recapitulates topographic features of the ECM and the internal architecture mimics the biological materials organization is engineered. The nanopatterned design along the XY plane is combined with a nanostructured organization along the Z axis on freestanding membranes prepared by layer-by-layer deposition of chitosan and chondroitin sulfate. Cellular behavior is monitored using two different mammalian cell lines, fibroblasts (L929) and myoblasts (C2C12), in order to perceive the response to topography...
March 29, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28367921/association-between-skin-condition-and-sleep-efficiency-in-japanese-young-adults
#18
Takahiro Yoshizaki, Yoshifumi Kimira, Hiroshi Mano, Masako Ota, Ken Iwatsuki, Yuichi Oishi, Takumi Yamane
There has been little epidemiological evidence that has comprehensively clarified whether alterations in lifestyle, such as sleep quality and dietary intake, explain changes in the skin condition of healthy young adults. Therefore, the aim of our study was to elucidate the association between skin condition and lifestyle behaviors such as diet and sleep, after statistically controlling confounding factors. The subjects were 54 participants who were aged 20-32 y, and who attended college in the Kanto region (in Japan)...
2017: Journal of Nutritional Science and Vitaminology
https://www.readbyqxmd.com/read/28367835/on-the-influence-of-raman-scattering-of-water-in-the-photoluminescence-measurement-of-water-dispersed-zno-nanocrystals
#19
Amarjyoti Kalita, Kuldeep Deka, Manos Pratim C Kalita
We present our investigation on the photoluminescence (PL) properties of water dispersed ZnO nanocrystals at various excitation wavelengths, and show that one peak in the emission spectrum (recorded by spectrofluorometer) changes its position when the excitation wavelength is changed. The relationship between the peak position and the excitation wavelength is found to be linear. Recording of the emission spectra (by spectrofluorometer) of water at different excitation wavelengths reveals that the linearly varying peak is present in them as well...
April 3, 2017: Methods and Applications in Fluorescence
https://www.readbyqxmd.com/read/28355490/phylogenomic-inferences-from-reference-mapped-and-i-de-novo-i-assembled-short-read-sequence-data-using-radseq-sequencing-of-california-white-oaks-i-quercus-i-subgenus-i-quercus-i
#20
Sorel Fitz-Gibbon, Andrew L Hipp, Kasey Khanh Pham, Paul S Manos, Victoria Sork
The emergence of next generation sequencing has increased by several orders of magnitude the amount of data available for phylogenetics. Reduced representation approaches, such as restriction-site associated DNA sequencing (RADseq), have proven useful for phylogenetic studies of non-model species at a wide range of phylogenetic depths. However, analysis of these datasets is not uniform and we know little about the potential benefits and drawbacks of <i>de novo</i> assembly versus assembly by mapping to a reference genome...
March 29, 2017: Genome Génome / Conseil National de Recherches Canada
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