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https://www.readbyqxmd.com/read/29042514/neuron-specific-methylome-analysis-reveals-epigenetic-regulation-and-tau-related-dysfunction-of-brca1-in-alzheimer-s-disease
#1
Tatsuo Mano, Kenichi Nagata, Takashi Nonaka, Airi Tarutani, Tomohiro Imamura, Tadafumi Hashimoto, Taro Bannai, Kagari Koshi-Mano, Takeyuki Tsuchida, Ryo Ohtomo, Junko Takahashi-Fujigasaki, Satoshi Yamashita, Yasumasa Ohyagi, Ryo Yamasaki, Shoji Tsuji, Akira Tamaoka, Takeshi Ikeuchi, Takaomi C Saido, Takeshi Iwatsubo, Toshikazu Ushijima, Shigeo Murayama, Masato Hasegawa, Atsushi Iwata
Alzheimer's disease (AD) is a chronic neurodegenerative disease characterized by pathology of accumulated amyloid β (Aβ) and phosphorylated tau proteins in the brain. Postmortem degradation and cellular complexity within the brain have limited approaches to molecularly define the causal relationship between pathological features and neuronal dysfunction in AD. To overcome these limitations, we analyzed the neuron-specific DNA methylome of postmortem brain samples from AD patients, which allowed differentially hypomethylated region of the BRCA1 promoter to be identified...
October 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29040229/development-of-a-liquid-chromatography-tandem-mass-spectrometric-method-for-quantification-of-mycophenolic-acid-and-its-glucuronides-in-dried-blood-spot-samples
#2
Hiromasa Iboshi, Hiroaki Yamaguchi, Hiroyuki Suzuki, Masafumi Kikuchi, Masaki Tanaka, Shinya Takasaki, Akiko Takahashi, Masamitsu Maekawa, Miki Shimada, Yasushi Matsuda, Yoshinori Okada, Nariyasu Mano
BACKGROUND: Personalized immunosuppressive therapy, including accurate drug dosing based on drug blood level, leads to better clinical outcomes, specifically with regard to avoidance of drug-induced adverse effects and maintenance of efficacy. Mycophenolic acid (MPA) is used as an immunosuppressant in transplantation of various solid organs. The aim of this study was to develop a method for quantification of MPA and its metabolites, mycophenolic acid 7-O-glucuronide (MPAG) and mycophenolic acid acyl glucuronide, in dried blood spot (DBS) samples, using liquid chromatography/electrospray ionization/tandem mass spectrometry...
October 14, 2017: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/29034587/open-fluidics-a-cell-culture-flow-system-developed-over-wettability-contrast-based-chips
#3
Nuno M Oliveira, Rui L Reis, João F Mano
Biological tissues are recurrently exposed to several dynamic mechanical forces that influence cell behavior. On this work, the focus is on the shear stress forces induced by fluid flow. The study of flow-induced effects on cells leads to important advances in cardiovascular, cancer, stem cell, and bone biology understanding. These studies are performed using cell culture flow (CCF) systems, mainly parallel plate flow chambers (PPFC), and microfluidic systems. Here, it is proposed an original CCF system based on the open fluidics concept...
October 16, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29034032/current-perspective-on-hemodialysis-patients-with-peripheral-artery-disease
#4
REVIEW
Shin Okamoto, Osamu Iida, Toshiaki Mano
The prevalence of peripheral artery disease is substantially higher in patients on chronic hemodialysis than in the general population. The presence of calcified lesions characteristic of hemodialysis patients has an adverse influence on the initial success and long-term outcomes of both surgical bypass and endovascular therapy. Although the selection of revascularization strategy depends on whether an autologous vein is available and if the patient has a life expectancy of at least two years, it is difficult to predict the life expectancy in a real-world clinical situation...
June 25, 2017: Annals of Vascular Diseases
https://www.readbyqxmd.com/read/29032473/oligosaccharide-biotechnology-an-approach-of-prebiotic-revolution-on-the-industry
#5
REVIEW
Mario Cezar Rodrigues Mano, Iramaia Angélica Neri-Numa, Juliana Bueno da Silva, Bruno Nicolau Paulino, Marina Gabriel Pessoa, Gláucia Maria Pastore
Oligosaccharides are polymers with two to ten monosaccharide residues which have sweetener functions and sensory characteristics, in addition to exerting physiological effects on human health. The ones called nondigestible exhibit a prebiotic behavior being fermented by colonic microflora or stimulating the growth of beneficial bacteria, playing roles in the immune system, protecting against cancer, and preventing cardiovascular and metabolic issues. The global prebiotics market is expected to grow around 12...
October 14, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29031770/effects-of-three-major-amino-acids-found-in-japanese-broth-on-glucose-metabolism-and-gastric-emptying
#6
Fumika Mano, Kaori Ikeda, Erina Joo, Shunsuke Yamane, Norio Harada, Nobuya Inagaki
OBJECTIVES: To our knowledge, the effect of the broth of dried kelp and dried bonito, dashi, on glucose metabolism and digestion has rarely been studied. Based on the component analysis of three actual broths served in traditional restaurants, a chemically synthesized broth with three free amino acids (histidine, glutamate, aspartate) and salt was prepared to investigate their effect on glucose metabolism, glucose-dependent insulinotropic polypeptide (GIP), and glucagon-like peptide 1 (GLP-1) secretion, and digestion...
August 10, 2017: Nutrition
https://www.readbyqxmd.com/read/29026733/safety-of-a-new-synbiotic-starter-formula
#7
Yvan Vandenplas, Antonis Analitis, Chara Tziouvara, Athina Kountzoglou, Anastasia Drakou, Manos Tsouvalas, Antigoni Mavroudi, Ioannis Xinias
PURPOSE: Breastfeeding is the best way to feed all infants, but not all infants can be (exclusively) breastfed. Cow's milk based infant formula is the second choice infant feeding. METHODS: The safety of a new synbiotic infant formula, supplemented with Bifidobacterium lactis and fructo-oligosaccharides, with lactose and a whey/casein 60/40 protein ratio was tested in 280 infants during 3 months. RESULTS: The median age of the infants at inclusion was 0...
September 2017: Pediatric Gastroenterology, Hepatology & Nutrition
https://www.readbyqxmd.com/read/29021848/scar-characteristics-derived-from-two-and-three-dimensional-reconstructions-of-cardiac-contrast-enhanced-magnetic-resonance-images-relationship-to-ventricular-tachycardia-inducibility-and-ablation-success
#8
Kazumasa Sonoda, Yasuo Okumura, Ichiro Watanabe, Koichi Nagashima, Hiroaki Mano, Rikitake Kogawa, Naoko Yamaguchi, Keiko Takahashi, Kazuki Iso, Kimie Ohkubo, Toshiko Nakai, Satoshi Kunimoto, Atsushi Hirayama
BACKGROUND: The relationship between cardiac contrast-enhanced magnetic resonance imaging (CE-MRI)-derived scar characteristics and substrate for ventricular tachycardia (VT) in patients with structural heart disease (SHD) has not been fully investigated. METHODS: This study included 51 patients (mean age, 63.3±15.1 years) who underwent CE-MRI with SHD and VT induction testing before ablation. Late gadolinium-enhanced (LGE) regions on MRI slices were quantified by thresholding techniques...
October 2017: Journal of Arrhythmia
https://www.readbyqxmd.com/read/29019521/-postpartum-depression-prevalence-and-associated-factors
#9
Juliana Mano Hartmann, Raul Andrés Mendoza-Sassi, Juraci Almeida Cesar
The aim was to identify the prevalence of postpartum depression and associated factors in women in a medium-sized city in Southern Brazil during 2013. Trained female interviewers applied a standardized questionnaire to all participants in the city's two maternity hospitals. The study analyzed demographic, socioeconomic, behavioral, social support, and disease characteristics. Screening for depression was done within the first 48 hours postpartum, using the Edinburgh Scale with a cutoff of ≥ 10. Multivariate analysis used Poisson regression with robust variance...
October 9, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/29019095/cost-effectiveness-of-surveillance-and-prevention-strategies-in-brca1-2-mutation-carriers
#10
Hideko Yamauchi, Chizuko Nakagawa, Makoto Kobayashi, Yusuke Kobayashi, Toshiki Mano, Seigo Nakamura, Masami Arai
BACKGROUND: Cost-effectiveness analysis is an important aspect of healthcare, including in Japan, where preventive measures for BRCA1/2 mutation carriers are not covered by health insurance. METHODS: We developed Markov models in a simulated cohort of women aged 35-70 years, and compared outcomes of surveillance with risk-reducing mastectomy (RRM) at age 35, risk-reducing salpingo-oophorectomy (RRSO) at age 45, and both (RRM&RRSO). We used breast and ovarian cancer incidences and adverse event rates from the previous studies, adjuvant chemotherapy, and hormonal therapy rates from the Hereditary Breast and Ovarian Cancer Registration 2015 in Japan, mortality rates from the National Cancer Center Hospital, Japan Society of Clinical Oncology, and Ministry of Health, Labour and Welfare, and direct costs from St...
October 10, 2017: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/29018230/affective-touch-enhances-self-face-recognition-during-multisensory-integration
#11
Elena Panagiotopoulou, Maria Laura Filippetti, Manos Tsakiris, Aikaterini Fotopoulou
Multisensory integration is a powerful mechanism for constructing body awareness and key for the sense of selfhood. Recent evidence has shown that the specialised C tactile modality that gives rise to feelings of pleasant, affective touch, can enhance the experience of body ownership during multisensory integration. Nevertheless, no study has examined whether affective touch can also modulate psychological identification with our face, the hallmark of our identity. The current study used the enfacement illusion paradigm to investigate the role of affective touch in the modulation of self-face recognition during multisensory integration...
October 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28987390/molecular-epidemiology-of-clostridium-difficile-infection-in-a-brazilian-cancer-hospital
#12
Cecília Leite Costa, Cibele Barreto Mano de Carvalho, Rafael Holanda González, Markus Andret Cavalcante Gifoni, Ronaldo de Albuquerque Ribeiro, Carlos Quesada-Gómez, Gerly Anne de Castro Brito
Clostridium difficile is a Gram-positive spore forming anaerobic bacterium and the main cause of healthcare-associated diarrhea. This study aimed to perform the phenotypic characterization and molecular typing of Clostridium difficile isolates among patients at a cancer hospital in Brazil. During 18 months, 48 diarrheic fecal samples were collected, of these 48% were positive in either one or both of the performed tests: detection of toxins A/B and culture. Clostridium difficile was recovered from four samples (17%)...
October 5, 2017: Anaerobe
https://www.readbyqxmd.com/read/28984133/evaporative-optical-marangoni-assembly-tailoring-the-three-dimensional-morphology-of-individual-deposits-of-nanoparticles-from-sessile-drops
#13
Manos Anyfantakis, Subramanyan Namboodiri Varanakkottu, Sergii Rudiuk, Mathieu Morel, Damien Baigl
We have recently devised the evaporative optical Marangoni assembly (eOMA), a novel and versatile interfacial flow-based method for directing the deposition of colloidal nanoparticles (NPs) on solid substrates from evaporating sessile drops along desired patterns using shaped UV light. Here, we focus on a fixed UV spot irradiation resulting in a cylinder-like deposit of assembled particles and show how the geometrical features of the single deposit can be tailored in three dimensions by simply adjusting the optical conditions or the sample composition, in a quantitative and reproducible manner...
October 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28978866/two-year-clinical-outcomes-post-implantation-of-epic-tm-self-expanding-nitinol-stents-for-the-aortoiliac-occlusive-disease-in-patients-with-peripheral-arterial-disease
#14
Takuya Tsujimura, Osamu Iida, Masashi Fujita, Masaharu Masuda, Shin Okamoto, Takayuki Ishihara, Kiyonori Nanto, Takashi Kanda, Shota Okuno, Yasuhiro Matsuda, Masahiko Fujihara, Yoshiaki Yokoi, Toshiaki Mano
AIM: We investigated 2-year clinical outcomes after implantaton of Epic(TM) self-expanding nitinol stents for patients with peripheral artery disease (PAD) due to the aortoiliac occlusive disease (AIOD). METHODS: This study was a multicenter and retrospective study. From February 2013 through October 2014, 292 lesions (chronic total occlusion, 21%; TASC Ⅱ C/D, 35%) in 217 consecutive patients (74±8 years; male, 81%; diabetes mellitus, 47%; dialysis, 21%; critical limb ischemia, 29%) who had undergone endovascular therapy (EVT) with Epic(TM) self-expanding nitinol stents for PAD with AIOD were analyzed...
October 5, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28977805/tomographic-structural-changes-of-retinal-layers-after-internal-limiting-membrane-peeling-for-macular-hole-surgery
#15
Mun Yueh Faria, Nuno P Ferreira, Diana M Cristóvao, Sofia Mano, David Cordeiro Sousa, Manuel Monteiro-Grillo
PURPOSE: To highlight tomographic structural changes of retinal layers after internal limiting membrane (ILM) peeling in macular hole surgery. METHODS: Nonrandomized prospective, interventional study in 38 eyes (34 patients) subjected to pars plana vitrectomy and ILM peeling for idiopathic macular hole. Retinal layers were assessed in nasal and temporal regions before and 6 months after surgery using spectral domain optical coherence tomography. RESULTS: Total retinal thickness increased in the nasal region and decreased in the temporal region...
October 5, 2017: Ophthalmic Research
https://www.readbyqxmd.com/read/28975410/halides-inhibition-of-multicopper-oxidases-studied-by-ftir-spectroelectrochemistry-using-azide-as-an-active-infrared-probe
#16
Chiara Di Bari, Nicolas Mano, Sergey Shleev, Marcos Pita, Antonio L De Lacey
An infrared spectroelectrochemical study of Trametes hirsuta laccase and Magnaporthe oryzae bilirubin oxidase has been performed using azide, an inhibitor of multicopper oxidases, as an active infrared probe incorporated into the T2/T3 copper cluster of the enzymes. The redox potential-controlled measurements indicate that N3(-) stretching IR bands of azide ion bound to the T2/T3 cluster are only detected for the oxidized enzymes, confirming that azide only binds to Cu(2+). Moreover, the process of binding/dissociation of azide ion is shown to be reversible...
October 3, 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/28973892/systems-biology-analysis-of-longitudinal-functional-response-of-endothelial-cells-to-shear-stress
#17
Nassim E Ajami, Shakti Gupta, Mano R Maurya, Phu Nguyen, Julie Yi-Shuan Li, John Y-J Shyy, Zhen Chen, Shu Chien, Shankar Subramaniam
Blood flow and vascular shear stress patterns play a significant role in inducing and modulating physiological responses of endothelial cells (ECs). Pulsatile shear (PS) is associated with an atheroprotective endothelial phenotype, while oscillatory shear (OS) is associated with an atheroprone endothelial phenotype. Although mechanisms of endothelial shear response have been extensively studied, most studies focus on characterization of single molecular pathways, mainly at fixed time points after stress application...
September 26, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28973155/high-throughput-screening-uncovers-mirnas-enhancing-glioblastoma-cell-susceptibility-to-tyrosine-kinase-inhibitors
#18
Pedro P Cunha, Pedro M Costa, Catarina M Morais, Inês R Lopes, Ana M Cardoso, Ana L Cardoso, Miguel Mano, Amália S Jurado, Maria C Pedroso de Lima
Glioblastoma (GBM) is a deadly and therapy resistant malignant brain tumour, characterized by an aggressive and diffuse growth pattern, which prevents complete surgical resection. Despite advances in the identification of genomic and molecular alterations that fuel the tumour, average patient survival post-diagnosis remains very low (∼14.6-months). In addition to being highly heterogeneous, GBM tumour cells exhibit high adaptive capacity to targeted molecular therapies owing to an established network of signalling cascades with functional redundancy, which provides them with robust compensatory survival mechanisms...
August 16, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28971570/chondroblastoma-of-extra-craniofacial-bones-clinicopathological-analyses-of-103-cases
#19
Eiichi Konishi, Yasuaki Nakashima, Masayuki Mano, Yasuhiko Tomita, Toshikazu Kubo, Nobuhito Araki, Eiichi Morii, Hideki Yoshikawa, Hironori Haga, Junya Toguchida, Takafumi Ueda, Masahiko Osawa, Manabu Hoshi, Takeshi Inoue, Masanari Aono, Akio Yanagisawa
We elucidated clinicopathological characteristics of chondroblastoma (CB) in Japan, and reliable clinicopathologic parameters predicting local recurrence and/or metastasis. Clinicopathological profiles of 103 CB (80 male, 23 female) in extra-craniofacial bones were retrieved. Numerical scoring of nine pathological and five radiological features was statistically analyzed to determine prognostic significance. Age ranged 8-61 years (average 19.6 years). Frequently involved sites were femur, tibia, calcaneus, patella and humerus...
October 2017: Pathology International
https://www.readbyqxmd.com/read/28970433/drug-use-before-and-during-pregnancy-in-japan-the-japan-environment-and-children-s-study
#20
Hidekazu Nishigori, Taku Obara, Toshie Nishigori, Hirohito Metoki, Mami Ishikuro, Satoshi Mizuno, Kasumi Sakurai, Nozomi Tatsuta, Ichiko Nishijima, Ikuma Fujiwara, Takahiro Arima, Kunihiko Nakai, Nariyasu Mano, Shinichi Kuriyama, Nobuo Yaegashi
Purpose: To elucidate drug use before and during pregnancy in Japan. Methods: The Japan Environment and Children's Study (JECS) is an ongoing nationwide birth cohort study. We analyzed data from JECS involving cases where drugs were used for 12 months before pregnancy was diagnosed, between the time of diagnosis of pregnancy until week 12 of pregnancy, and after week 12 of pregnancy. Results: We analyzed data from 97,464 pregnant women. The percentages of pregnant women who had taken one or more drugs and supplements before diagnosis of pregnancy, between the time of diagnosis of pregnancy until week 12 of pregnancy, and after week 12 of pregnancy, were 78...
April 10, 2017: Pharmacy (Basel, Switzerland)
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