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https://www.readbyqxmd.com/read/28345940/early-development-of-mechanisms-of-change-as-a-predictor-of-subsequent-change-and-treatment-outcome-the-case-of-working-alliance
#1
Sigal Zilcha-Mano, Paula Errázuriz
OBJECTIVE: Advanced statistical tools have created the opportunity to systematically examine the effect of early trajectories in predictors of therapeutic change, such as early alliance development patterns, on outcome. To date, however, these methods have been used almost exclusively to examine the effect of the development of early symptoms on later ones. Development patterns of alliance early in treatment, and their association with treatment outcome, have received much theoretical attention, but few systematic examinations have been conducted so far...
March 27, 2017: Journal of Consulting and Clinical Psychology
https://www.readbyqxmd.com/read/28345212/cardiac-iodine-123-metaiodobenzylguanidine-scintigraphy-may-be-useful-to-identify-pathologic-from-physiologic-sinus-bradycardia
#2
Akihiro Sunaga, Masaharu Masuda, Masashi Fujita, Osamu Iida, Takashi Kanda, Yasuhiro Matsuda, Takakazu Morozumi, Toshiaki Mano, Masaaki Uematsu
BACKGROUND: Sinus bradycardia includes pathologic sick sinus syndrome (SSS) and physiologic bradycardia such as athletes' heart. Pacemaker implantation is indicated for patients with symptomatic SSS; however, the indication remains difficult to determine in those with mild and/or unspecific symptoms. The sympathetic tone is increased in response to reduced cardiac output in SSS, whereas excessive vagal tone has been seen in physiological bradycardia. We sought to determine if cardiac iodine-123-metaiodobenzylguanidine scintigraphy ((123) I-MIBG) was useful in differentiating pathologic from physiologic sinus bradycardia...
March 27, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28343243/fusarium-species-a-promising-tool-box-for-industrial-biotechnology
#3
REVIEW
Marina Gabriel Pessôa, Bruno Nicolau Paulino, Mario Cezar Rodrigues Mano, Iramaia Angélica Neri-Numa, Gustavo Molina, Glaucia Maria Pastore
Global demand for biotechnological products has increased steadily over the years. Thus, need for optimized processes and reduced costs appear as a key factor in the success of this market. A process tool of high importance is the direct or indirect use of enzymes to catalyze the generation of various substances. Also, obtaining aromas and pigments from natural sources has becoming priority in cosmetic and food industries in order to supply the demand from consumers to substitute synthetic compounds, especially when by-products can be used as starting material for this purpose...
March 25, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28342655/tacrolimus-induced-reversible-cerebral-vasoconstriction-syndrome-with-delayed-multi-segmental-vasoconstriction
#4
Satoshi Kodama, Tatsuo Mano, Akihiro Masuzawa, Yasutaka Hirata, Yuki Nagasako, Kagari Koshi Mano, Masashi Hamada, Yasuo Terao, Toshihiro Hayashi, Minoru Ono, Shoji Tsuji
Reversible cerebral vasoconstriction syndrome (RCVS) is a cerebrovascular syndrome characterized by multi-segmental constrictions of the cerebral arteries that resolves spontaneously within 3 months. Although RCVS is considered to be due to transient dysregulation of vascular tone, the exact pathomechanism remains unclear. We describe the case of a 15-year-old girl with RCVS induced by tacrolimus, who developed generalized seizure during the postoperative course of orthotropic heart transplantation. Magnetic resonance imaging at symptom onset showed a few vasoconstrictions accompanying brain edema and convexity subarachnoid hemorrhage...
March 22, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28342299/plasma-microrna-signature-predicting-weight-gain-among-mexican-american-women
#5
Hua Zhao, Jie Shen, Carrie Daniel-MacDougall, Xifeng Wu, Wong-Ho Chow
OBJECTIVE: There is growing evidence that circulating microRNAs (miRNAs) play an important role in obesity. However, whether they can contribute to adult weight gain is still unclear. METHODS: In the training set with 40 nonsmoking, healthy women identified from the Mano-A-Mano Mexican American Cohort study, global circulating miRNA profiles in plasma samples were assessed. Cox proportional hazard regression was used to assess the effects of plasma miRNAs on significant weight gain during a 5-year follow-up...
March 25, 2017: Obesity
https://www.readbyqxmd.com/read/28334126/heartfelt-self-cardio-visual-integration-affects-self-face-recognition-and-interoceptive-cortical-processing
#6
Alejandra Sel, Ruben T Azevedo, Manos Tsakiris
The sense of body-ownership relies on the representation of both interoceptive and exteroceptive signals coming from one's body. However, it remains unknown how the integration of bodily signals coming from "outside" and "inside" the body is instantiated in the brain. Here, we used a modified version of the Enfacement Illusion to investigate whether the integration of visual and cardiac information can alter self-face recognition (Experiment 1) and neural responses to heartbeats (Experiment 2). We projected a pulsing shade, that was synchronous or asynchronous with the participant's heartbeat, onto a picture depicting the participant's face morphed with the face of an unfamiliar other...
October 5, 2016: Cerebral Cortex
https://www.readbyqxmd.com/read/28330223/multi-response-optimization-for-enhanced-xylitol-production-by-debaryomyces-nepalensis-in-bioreactor
#7
J Sharon Mano Pappu, Sathyanarayana N Gummadi
In this study, the optimization of different process variables-pH (4-6), aeration rate (200-550 rpm) and agitation rate (0.6-1.8 vvm) were investigated using rotating simplex method and uniform design method to enhance xylitol production from xylose by D. nepalensis in a batch stirred tank bioreactor. Maximum xylitol productivity (0.576 g L(-1) h(-1)) was obtained at pH 4.0, agitation 300 rpm and aeration 1.5 vvm by rotating simplex method. Individual optimum values of pH, agitation and aeration are 4...
December 2016: 3 Biotech
https://www.readbyqxmd.com/read/28327834/-performance-of-cognitive-brief-test-in-elderly-patients-with-dementia-in-advanced-stage-living-in-an-urban-community-of-lima-peru
#8
Nilton Custodio, Carlos Alva-Diaz, Yahaira Becerra-Becerra, Rosa Montesinos, David Lira, Eder Herrera-Pérez, Sheila Castro-Suárez, José Cuenca-Alfaro, Elizabeth Valeriano-Lorenzo
Objectives.: Evaluate the performance of clock drawing test- Manos versión (PDR-M) and Mini Mental State Examination -Peruvian version (MMSE) to detect dementia in a sample based on urban community of Lima, Peru. Materials and methods.: This study is a secondary analysis database, observational, analytical and cross-sectional, the gold standard was the clinical and the neuropsychological evaluations together. Performance testing individually and in combination were evaluated...
October 2016: Revista Peruana de Medicina Experimental y Salud Pública
https://www.readbyqxmd.com/read/28318797/early-symptom-trajectories-as-predictors-of-treatment-outcome-for-citalopram-versus-placebo
#9
Sigal Zilcha-Mano, Steven P Roose, Patrick J Brown, Bret R Rutherford
OBJECTIVES: The high percentage of failed clinical trials for anti-depressant medications, especially in elderly populations, obscures the fact that some patients may benefit greatly from treatment. Early detection of patients who may benefit most from antidepressant medication may improve treatment decisions. We examined whether depressed patients in a large clinical trial exhibit distinct trajectories of early symptom change that predict differential response to medication or placebo...
February 3, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28302483/production-of-an-active-form-of-vitamin-d2-by-genetically-engineered-cyp105a1
#10
Kaori Yasuda, Yuya Yogo, Hiroshi Sugimoto, Hiroki Mano, Teisuke Takita, Miho Ohta, Masaki Kamakura, Shinichi Ikushiro, Kiyoshi Yasukawa, Yoshitsugu Shiro, Toshiyuki Sakaki
Our previous studies revealed that CYP105A1 can convert vitamin D3 (VD3) to its active form, 1α,25-dihydroxyvitamin D3 (1,25D3). Site-directed mutagenesis of CYP105A1 based on its crystal structure dramatically enhanced its activity; the activity of double variants R73A/R84A and R73A/R84V was more than 100-fold higher than that of the wild type of CYP105A1. In contrast, these variants had a low ability to convert vitamin D2 (VD2) to 1α,25-dihydroxyvitamin D2 (1,25D2), whereas they catalyzed the sequential hydroxylation at positions C25 and C26 to produce 25,26D2...
March 13, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28300339/adolescent-interviewing-skills-effect-of-feedback
#11
Genna Bourget, Nadim Joukhadar, Sarah Manos, Karen Mann, Jill Hatchette, Kim Blake
BACKGROUND: Communicating with adolescent patients can be challenging. Our study assessed the effect of structured feedback following a standardised patient (SP) encounter on postgraduate year-1 (PGY1) residents' adolescent-specific communication skills. Communicating with adolescent patients can be challenging METHODS: A two-group, prospective, double-blind randomised control study design was employed. Measures were taken before and after the intervention. PGY1 residents conducted a 30-minute interview with an SP adolescent-mother pair, who then individually scored the resident's performance using the validated Structured Communication Adolescent Guide (SCAG)...
March 16, 2017: Clinical Teacher
https://www.readbyqxmd.com/read/28292904/optimal-run-and-tumble-based-transportation-of-a-janus-particle-with-active-steering
#12
Tomoyuki Mano, Jean-Baptiste Delfau, Junichiro Iwasawa, Masaki Sano
Although making artificial micrometric swimmers has been made possible by using various propulsion mechanisms, guiding their motion in the presence of thermal fluctuations still remains a great challenge. Such a task is essential in biological systems, which present a number of intriguing solutions that are robust against noisy environmental conditions as well as variability in individual genetic makeup. Using synthetic Janus particles driven by an electric field, we present a feedback-based particle-guiding method quite analogous to the "run-and-tumbling" behavior of Escherichia coli but with a deterministic steering in the tumbling phase: the particle is set to the run state when its orientation vector aligns with the target, whereas the transition to the "steering" state is triggered when it exceeds a tolerance angle [Formula: see text] The active and deterministic reorientation of the particle is achieved by a characteristic rotational motion that can be switched on and off by modulating the ac frequency of the electric field, which is reported in this work...
March 14, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28287948/spectrum-of-ct-findings-in-thoracic-extranodal-non-hodgkin-lymphoma
#13
Mathew P Bligh, Joy N Borgaonkar, Steven C Burrell, David A MacDonald, Daria Manos
Non-Hodgkin lymphoma (NHL) frequently manifests in extranodal structures in the chest, often in the form of secondary involvement but occasionally as primary disease. Because staging and treatment are affected by the presence of extranodal disease at imaging, radiologists' interpretation and management of suspicious findings are critical to patient care. Unfortunately, owing to considerable imaging overlap with other diseases, primary extranodal lymphoma is difficult to diagnose with imaging alone. Radiologists should have a heightened degree of suspicion in patients at risk (including patients with immune compromise, autoimmune diseases, or a history of stem cell or solid organ transplant) or with particular imaging appearances (including the vertebral wraparound sign, nonresolving consolidation, an infiltrative soft-tissue mass, and lesions demonstrating vascular encasement without invasion)...
March 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28274611/matrix-effect-corrected-liquid-chromatography-tandem-mass-spectrometric-method-for-determining-acylcarnitines-in-human-urine
#14
Kazuki Abe, Hiroyuki Suzuki, Masamitsu Maekawa, Miki Shimada, Hiroaki Yamaguchi, Nariyasu Mano
Administration of pivalate-containing antibiotics decreases serum carnitine and increases urinary pivaloylcarnitine, resulting in hypocarnitinemia. Carnitine and acylcarnitines are important biomarkers in the diagnosis of carnitine deficiency, but the relationship between acylcarnitines and drug-induced hypocarnitinemia remains unclear. Quantification of acylcarnitines enables discovery of new biomarkers for prediction and diagnosis of drug-induced hypocarnitinemia. Here we describe a liquid chromatography/tandem mass-spectrometric method for simultaneously quantifying carnitine, 15 acylcarnitines, and cefditoren (the pivoxilated product of an antibiotic prodrug) in human urine...
March 6, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28263650/supportive-expressive-interventions-in-working-through-treatment-termination
#15
Aviv Nof, Liat Leibovich, Sigal Zilcha-Mano
Supportive-expressive (SE) psychodynamic treatment has been receiving much empirical support. It is based on conceptualizing and working through the patients' Core Conflictual Relationship Theme, which includes their main wish (W) in the context of an interpersonal relationship, an actual or anticipated subjective response from the other (RO) in relation to the W, and the subsequent emotional and behavioral response from the self (RS) to the RO. Studies suggest that the RO and RS components show the greatest change as a result of effective SE treatment...
March 2017: Psychotherapy
https://www.readbyqxmd.com/read/28256890/optically-imaged-striped-domains-of-nonequilibrium-electronic-and-nuclear-spins-in-a-fractional-quantum-hall-liquid
#16
John N Moore, Junichiro Hayakawa, Takaaki Mano, Takeshi Noda, Go Yusa
Using photoluminescence microscopy enhanced by magnetic resonance, we visualize in real space both electron and nuclear polarization occurring in nonequilibrium fraction quantum Hall (FQH) liquids. We observe stripelike domain regions comprising FQH excited states which discretely form when the FQH liquid is excited by a source-drain current. These regions are deformable and give rise to bidirectionally polarized nuclear spins as spin-resolved electrons flow across their boundaries.
February 17, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28254006/quantification-of-dna-fragmentation-in-processed-foods-using-real-time-pcr
#17
Junichi Mano, Yasuyuki Nishitsuji, Yosuke Kikuchi, Shin-Ichi Fukudome, Takuya Hayashida, Hiroyuki Kawakami, Youichi Kurimoto, Akio Noguchi, Kazunari Kondo, Reiko Teshima, Reona Takabatake, Kazumi Kitta
DNA analysis of processed foods is performed widely to detect various targets, such as genetically modified organisms (GMOs). Food processing often causes DNA fragmentation, which consequently affects the results of PCR analysis. In order to assess the effects of DNA fragmentation on the reliability of PCR analysis, we investigated a novel methodology to quantify the degree of DNA fragmentation. We designed four real-time PCR assays that amplified 18S ribosomal RNA gene sequences common to various plants at lengths of approximately 100, 200, 400, and 800 base pairs (bp)...
July 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28245142/diagnostic-reference-levels-and-monitoring-practice-can-help-reduce-patient-dose-from-ct-examinations
#18
Elena Tonkopi, Susan Duffy, Mohamed Abdolell, Daria Manos
OBJECTIVE: The purpose of this study is to establish provincial diagnostic reference levels (DRLs) and to determine whether this process may help reduce the patient radiation dose from the most frequently performed CT examinations. MATERIALS AND METHODS: We investigated the following CT examinations: head, chest, low-dose chest, abdomen and pelvis, and chest, abdomen, and pelvis examinations. The sample for each protocol included 15 patients of average body weight (mean [± SD], 70 ± 20 kg)...
February 28, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28241834/subjective-social-status-social-network-and-health-disparities-empirical-evidence-from-greece
#19
Antonios Charonis, Ilias-Ioannis Kyriopoulos, Manos Spanakis, Dimitris Zavras, Kostas Athanasakis, Elpida Pavi, John Kyriopoulos
BACKGROUND: Several studies suggest that socioeconomic status affects (SES) affects self-rated health (SRH), both in Greece and internationally. However, prior research mainly uses objective measures of SES, instead of subjective evaluations of individuals' social status. Based on this, this paper aims to examine (a) the impact of the economic dowturn on SRH in Greece and (b) the relationship between subjective social status (SSS), social network and SRH. METHODS: The descriptive analysis is based on four cross-sectional surveys conducted by the National School of Public Health, Athens, Greece (2002, 2006, 2011, 2015), while the data for the empirical investigation were derived from the 2015 survey (Health + Welfare Survey GR)...
February 27, 2017: International Journal for Equity in Health
https://www.readbyqxmd.com/read/28236268/production-of-electrospun-fast-dissolving-drug-delivery-systems-with-therapeutic-eutectic-systems-encapsulated-in-gelatin
#20
Francisca Mano, Marta Martins, Isabel Sá-Nogueira, Susana Barreiros, João Paulo Borges, Rui L Reis, Ana Rita C Duarte, Alexandre Paiva
Fast-dissolving delivery systems (FDDS) have received increasing attention in the last years. Oral drug delivery is still the preferred route for the administration of pharmaceutical ingredients. Nevertheless, some patients, e.g. children or elderly people, have difficulties in swallowing solid tablets. In this work, gelatin membranes were produced by electrospinning, containing an encapsulated therapeutic deep-eutectic solvent (THEDES) composed by choline chloride/mandelic acid, in a 1:2 molar ratio. A gelatin solution (30% w/v) with 2% (v/v) of THEDES was used to produce electrospun fibers and the experimental parameters were optimized...
February 24, 2017: AAPS PharmSciTech
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