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JOURNAL ARTICLE
J L Fachi, L P Pral, J A C Dos Santos, A C Codo, S de Oliveira, J S Felipe, F F F Zambom, N O S Câmara, P M M M Vieira, M Colonna, M A R Vinolo
Group 3 innate lymphoid cells (ILC3) have a prominent role in the maintenance of intestine mucosa homeostasis. The hypoxia-inducible factor (HIF) is an important modulator of immune cell activation and a key mechanism for cellular adaptation to oxygen deprivation. However, its role on ILC3 is not well known. In this study, we investigated how a hypoxic environment modulates ILC3 response and the subsequent participation of HIF-1 signaling in this process. We found increased proliferation and activation of intestinal ILC3 at low oxygen levels, a response that was phenocopied when HIF-1α was chemically stabilized and was reversed when HIF-1 was blocked...
July 2021: Mucosal Immunology
#22
JOURNAL ARTICLE
Inigo Soteras, Carolina Codo, Mia Derstine, Martin E Musi
No abstract text is available yet for this article.
March 2021: Wilderness & Environmental Medicine
#23
JOURNAL ARTICLE
Hanumanthappa Srikantha, Mahesh Shivaswamy, Sahana Mahesh
Copper and stainless steel electrodes were used in batch electrochemical coagulation (BECC) for the treatment of real textile wastewater using 16 electrode combinations. Out of 16 Cu-SS and SS-Cu combinations (eight combinations each), only 4SS and 3SS-1Cu electrodes operated at cell voltage of 18 V and current density of 180 A/m2 gave maximum color and chemical oxygen demand (COD) removals. The COD removal was observed to be 89.37% for 4SS and 72.34% for 3SS 1Cu electrodes from CODo 3,012 mg/L. Color removal was 97% and 98% from its initial value of 1,000 Pt-Co unit for 4SS and 3SS-1Cu combinations...
October 2020: Water Science and Technology: a Journal of the International Association on Water Pollution Research
#24
Ana Campos Codo, Gustavo Gastão Davanzo, Lauar de Brito Monteiro, Gabriela Fabiano de Souza, Stéfanie Primon Muraro, João Victor Virgilio-da-Silva, Juliana Silveira Prodonoff, Victor Corasolla Carregari, Carlos Alberto Oliveira de Biagi Junior, Fernanda Crunfli, Jeffersson Leandro Jimenez Restrepo, Pedro Henrique Vendramini, Guilherme Reis-de-Oliveira, Karina Bispo Dos Santos, Daniel A Toledo-Teixeira, Pierina Lorencini Parise, Matheus Cavalheiro Martini, Rafael Elias Marques, Helison R Carmo, Alexandre Borin, Laís Durço Coimbra, Vinícius O Boldrini, Natalia S Brunetti, Andre S Vieira, Eli Mansour, Raisa G Ulaf, Ana F Bernardes, Thyago A Nunes, Luciana C Ribeiro, Andre C Palma, Marcus V Agrela, Maria Luiza Moretti, Andrei C Sposito, Fabrício Bíscaro Pereira, Licio Augusto Velloso, Marco Aurélio Ramirez Vinolo, André Damasio, José Luiz Proença-Módena, Robson Francisco Carvalho, Marcelo A Mori, Daniel Martins-de-Souza, Helder I Nakaya, Alessandro S Farias, Pedro M Moraes-Vieira
No abstract text is available yet for this article.
September 1, 2020: Cell Metabolism
#25
JOURNAL ARTICLE
Ana Campos Codo, Gustavo Gastão Davanzo, Lauar de Brito Monteiro, Gabriela Fabiano de Souza, Stéfanie Primon Muraro, João Victor Virgilio-da-Silva, Juliana Silveira Prodonoff, Victor Corasolla Carregari, Carlos Alberto Oliveira de Biagi Junior, Fernanda Crunfli, Jeffersson Leandro Jimenez Restrepo, Pedro Henrique Vendramini, Guilherme Reis-de-Oliveira, Karina Bispo Dos Santos, Daniel A Toledo-Teixeira, Pierina Lorencini Parise, Matheus Cavalheiro Martini, Rafael Elias Marques, Helison R Carmo, Alexandre Borin, Laís Durço Coimbra, Vinícius O Boldrini, Natalia S Brunetti, Andre S Vieira, Eli Mansour, Raisa G Ulaf, Ana F Bernardes, Thyago A Nunes, Luciana C Ribeiro, Andre C Palma, Marcus V Agrela, Maria Luiza Moretti, Andrei C Sposito, Fabrício Bíscaro Pereira, Licio Augusto Velloso, Marco Aurélio Ramirez Vinolo, André Damasio, José Luiz Proença-Módena, Robson Francisco Carvalho, Marcelo A Mori, Daniel Martins-de-Souza, Helder I Nakaya, Alessandro S Farias, Pedro M Moraes-Vieira
COVID-19 can result in severe lung injury. It remained to be determined why diabetic individuals with uncontrolled glucose levels are more prone to develop the severe form of COVID-19. The molecular mechanism underlying SARS-CoV-2 infection and what determines the onset of the cytokine storm found in severe COVID-19 patients are unknown. Monocytes and macrophages are the most enriched immune cell types in the lungs of COVID-19 patients and appear to have a central role in the pathogenicity of the disease. These cells adapt their metabolism upon infection and become highly glycolytic, which facilitates SARS-CoV-2 replication...
September 1, 2020: Cell Metabolism
#26
EDITORIAL
Ana Campos Codo, Pedro Manoel Mendes Moraes-Vieira
No abstract text is available yet for this article.
July 2020: Journal of Allergy and Clinical Immunology
#27
Gilles Roussine Codo, Sarra Khennas
No abstract text is available yet for this article.
June 2020: Médecine Sciences: M/S
#28
JOURNAL ARTICLE
Adrian M Altenhoff, Javier Garrayo-Ventas, Salvatore Cosentino, David Emms, Natasha M Glover, Ana Hernández-Plaza, Yannis Nevers, Vicky Sundesha, Damian Szklarczyk, José M Fernández, Laia Codó, Josep Ll Gelpi, Jaime Huerta-Cepas, Wataru Iwasaki, Steven Kelly, Odile Lecompte, Matthieu Muffato, Maria J Martin, Salvador Capella-Gutierrez, Paul D Thomas, Erik Sonnhammer, Christophe Dessimoz
The identification of orthologs-genes in different species which descended from the same gene in their last common ancestor-is a prerequisite for many analyses in comparative genomics and molecular evolution. Numerous algorithms and resources have been conceived to address this problem, but benchmarking and interpreting them is fraught with difficulties (need to compare them on a common input dataset, absence of ground truth, computational cost of calling orthologs). To address this, the Quest for Orthologs consortium maintains a reference set of proteomes and provides a web server for continuous orthology benchmarking (https://orthology...
May 6, 2020: Nucleic Acids Research
#29
JOURNAL ARTICLE
Lauar de Brito Monteiro, Gustavo Gastão Davanzo, Cristhiane Fávero de Aguiar, Felipe Corrêa da Silva, Jessica Rodrigues de Andrade, Ana Campos Codo, Jessica Aparecida da Silva Pereira, Leonardo Pimentel de Freitas, Pedro Manoel Moraes-Vieira
Macrophages are essential components of the immune system. Macrophages can be derived from the bone marrow of mice with either recombinant M-CSF or L929 supernatant. Recent literature considers recombinant M-CSF- and L929-derived macrophages as equals, even though L929-derived macrophages are exposed to other substances secreted in the L929 supernatant, and not only M-CSF. Thus, we decided to perform a comparative analysis of both inflammatory and metabolic profiles of macrophages differentiated under the aforementioned conditions, which is relevant for standardization and interpretation of in vitro studies...
March 19, 2020: Immunobiology
#30
JOURNAL ARTICLE
Ana Carolina Monteiro de Souza Lima, Kevin Augusto Farias de Alvarenga, Beatriz Campos Codo, Erika Kelmer Sacramento, Daniela Valadão Freitas Rosa, Renan Pedra Souza, Marco Aurélio Romano-Silva, Bruno Rezende Souza
Many neuropsychiatric disorders are associated with both dopaminergic (DAergic) and developmental hypotheses. Since DAergic receptors are expressed in the developing brain, it is possible that alterations in dopamine (DA) signaling may impair brain development and consequent behavior. In our previous study, using a zebrafish model, we showed that an increase of DA during the 3- to 5-days post fertilization (dpf) developmental window (an important window for GABAergic neuronal differentiation) affects the motor behavior of 5 dpf larvae...
January 28, 2020: International Journal of Developmental Neuroscience
#31
JOURNAL ARTICLE
Carine Fortes Aragão, Valéria Cristina Soares Pinheiro, Joaquim Pinto Nunes Neto, Eliana Vieira Pinto da Silva, Glennda Juscely Galvão Pereira, Bruna Laís Sena do Nascimento, Karoline da Silva Castro, Ariadne Mendonça Maia, Clistenes Pamplona Catete, Lívia Carício Martins, Wanderli Pedro Tadei, Sandro Patroca da Silva, Ana Cecília Ribeiro Cruz
Dengue fever, chikungunya, and Zika are diseases caused by viruses transmitted by Aedes aegypti and Aedes albopictus . In Brazil, the number of human infections is high, but few studies are performed in mosquito vectors. This study aimed to investigate the presence of Zika, Dengue and Chikungunya viruses in Ae. aegypti and Ae. albopictus from the municipalities of Alto Alegre, Caxias, Codó, and São Mateus do Maranhão, located in the state of Maranhão, Northeast Brazil. The mosquitoes were collected with a mechanical aspirator, identified, triturated, and then submitted to RNA extraction and RT-qPCR...
December 5, 2019: Viruses
#32
JOURNAL ARTICLE
Smaïla Ouédraogo, Manfred Accrombessi, Ismaël Diallo, Roussine Codo, Adama Ouattara, Laurent Ouédraogo, Achille Massougbodji, Michel Cot
Introduction: Placental malaria (PM) is an important predictor of infant morbidity and mortality in sub-Saharan Africa. Although placental histology is the gold standard test to diagnose PM, the placenta impression smears remains widely used in epidemiological studies. This study is set to evaluate the performance of placental impression smears to detect PM in pregnant women in southern Benin. Methods: A cross-sectional analysis was performed on data collected in the framework a multicenter randomized clinical trial (Malaria in Pregnancy Preventive and Alternative Drugs)...
2019: Pan African Medical Journal
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JOURNAL ARTICLE
Suzana Aparecida S Queiroz, Meri Emili F Pinto, Antonio F Bobey, Helena M Russo, Andrea N L Batista, Joao M Batista, Ana C Codo, Alexandra I Medeiros, Vanderlan S Bolzani
ETHNOPHARMACOLOGICAL RELEVANCE: Croton floribundus Spreng. (Euphorbiaceae), popularly known as Capixinguí, stands out due to its widespread use in traditional medicine to treat wounds, syphilis, hemorrhoids, eye diseases and as a purgative. AIM OF THE STUDY: To characterize clerodanes diterpenes from C. floribundus and to evaluate the effects of the fraction and diterpenes (1-5) through inhibition of nitrite production. MATERIALS AND METHODS: The hydroethanolic root extract of C...
October 19, 2019: Journal of Ethnopharmacology
#34
JOURNAL ARTICLE
Felipe Corrêa da Silva, Cristhiane Favero de Aguiar, Jéssica A S Pereira, Lauar de Brito Monteiro, Gustavo Gastão Davanzo, Ana Campos Codo, Leonardo Pimentel de Freitas, Aline Siqueira Berti, Danilo Ferruci, Bianca Gazieri Castelucci, Sílvio Roberto Consonni, Hernandes F Carvalho, Pedro M M Moraes-Vieira
Over the past years, systemic derived cues that regulate cellular metabolism have been implicated in the regulation of immune responses. Ghrelin is an orexigenic hormone produced by enteroendocrine cells in the gastric mucosa with known immunoregulatory roles. The mechanism behind the function of ghrelin in immune cells, such as macrophages, is still poorly understood. Here, we explored the hypothesis that ghrelin leads to alterations in macrophage metabolism thus modulating macrophage function. We demonstrated that ghrelin exerts an immunomodulatory effect over LPS-activated peritoneal macrophages, as evidenced by inhibition of TNF-α and IL-1β secretion and increased IL-12 production...
September 13, 2019: Free Radical Biology & Medicine
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JOURNAL ARTICLE
Pau Andrio, Adam Hospital, Javier Conejero, Luis Jordá, Marc Del Pino, Laia Codo, Stian Soiland-Reyes, Carole Goble, Daniele Lezzi, Rosa M Badia, Modesto Orozco, Josep Ll Gelpi
In the recent years, the improvement of software and hardware performance has made biomolecular simulations a mature tool for the study of biological processes. Simulation length and the size and complexity of the analyzed systems make simulations both complementary and compatible with other bioinformatics disciplines. However, the characteristics of the software packages used for simulation have prevented the adoption of the technologies accepted in other bioinformatics fields like automated deployment systems, workflow orchestration, or the use of software containers...
September 10, 2019: Scientific Data
#36
JOURNAL ARTICLE
Diana Buitrago, Laia Codó, Ricard Illa, Pau de Jorge, Federica Battistini, Oscar Flores, Genis Bayarri, Romina Royo, Marc Del Pino, Simon Heath, Adam Hospital, Josep Lluís Gelpí, Isabelle Brun Heath, Modesto Orozco
We present Nucleosome Dynamics, a suite of programs integrated into a virtual research environment and created to define nucleosome architecture and dynamics from noisy experimental data. The package allows both the definition of nucleosome architectures and the detection of changes in nucleosomal organization due to changes in cellular conditions. Results are displayed in the context of genomic information thanks to different visualizers and browsers, allowing the user a holistic, multidimensional view of the genome/transcriptome...
October 10, 2019: Nucleic Acids Research
#37
JOURNAL ARTICLE
Rafaella Regina Alves Peixoto, Carla Regina Bianchi Codo, Vitor Lacerda Sanches, Tamara Cristina Guiraldelo, Fábio Ferreira da Silva, Rafael Luis Ribessi, Sérgio Tadeu Martins Marba, Solange Cadore
BACKGROUND: Human milk is a dynamic food and some important differences in composition can be found between the milk from preterm and terms infants. Additionally, in some situations, the mother's own milk is unavailable and the use of milk from human milk banks is considered as the most appropriate substitute. In this way, concentrations of trace elements (Ba, Cu, Fe, Mn, Mo, Se, Sr, and Zn) were determined in human milk, considering the differences about preterm and term human milk and its processing in a human milk bank...
July 2019: Journal of Trace Elements in Medicine and Biology
#38
JOURNAL ARTICLE
Adrià Aterido, Núria Palau, Eugeni Domènech, Pilar Nos Mateu, Ana Gutiérrez, Fernando Gomollón, Juan L Mendoza, Esther Garcia-Planella, Manuel Barreiro-de Acosta, Fernando Muñoz, Maribel Vera, Cristina Saro, Maria Esteve, Montserrat Andreu, María Chaparro, Julián Panés, Valle García-Sánchez, María López-Lasanta, Andrea Pluma, Laia Codó, Andrés García-Montero, Josep Manyé, Javier P Gisbert, Sara Marsal, Antonio Julià
The production of antibodies to anti-tumor necrosis factor alpha (TNF) agents is one of the main causes of treatment failure in Crohn's disease (CD). To date, however, the contribution of genetics to anti-TNF immunogenicity in CD is still unknown. The objective of the present study was to identify genetic variation associated with anti-TNF immunogenicity in CD. We performed a two-stage genome-wide association study in a cohort of 96 and 123 adalimumab-treated patients, respectively. In the discovery stage, we identified a genome-wide significant association between the CD96 locus and the production of antibodies to anti-TNF treatment (P = 1...
May 2, 2019: Pharmacogenomics Journal
#39
JOURNAL ARTICLE
Adrià Aterido, Juan D Cañete, Jesús Tornero, Carlos Ferrándiz, José Antonio Pinto, Jordi Gratacós, Rubén Queiró, Carlos Montilla, Juan Carlos Torre-Alonso, José J Pérez-Venegas, Antonio Fernández Nebro, Santiago Muñoz-Fernández, Carlos M González, Daniel Roig, Pedro Zarco, Alba Erra, Jesús Rodríguez, Santos Castañeda, Esteban Rubio, Georgina Salvador, Cesar Díaz-Torné, Ricardo Blanco, Alfredo Willisch Domínguez, José Antonio Mosquera, Paloma Vela, Simon Angel Sánchez-Fernández, Héctor Corominas, Julio Ramírez, Pablo de la Cueva, Eduardo Fonseca, Emilia Fernández, Lluis Puig, Esteban Dauden, José Luís Sánchez-Carazo, José Luís López-Estebaranz, David Moreno, Francisco Vanaclocha, Enrique Herrera, Francisco Blanco, Benjamín Fernández-Gutiérrez, Antonio González, Carolina Pérez-García, Mercedes Alperi-López, Alejandro Olivé Marques, Víctor Martínez-Taboada, Isidoro González-Álvaro, Raimon Sanmartí, Carlos Tomás Roura, Andrés C García-Montero, Sílvia Bonàs-Guarch, Josep Maria Mercader, David Torrents, Laia Codó, Josep Lluís Gelpí, Mireia López-Corbeto, Andrea Pluma, Maria López-Lasanta, Raül Tortosa, Nuria Palau, Devin Absher, Richard Myers, Sara Marsal, Antonio Julià
OBJECTIVE: Psoriatic arthritis (PsA) is a chronic inflammatory arthritis affecting up to 30% of patients with psoriasis (Ps). To date, most of the known risk loci for PsA are shared with Ps, and identifying disease-specific variation has proven very challenging. The objective of the present study was to identify genetic variation specific for PsA. METHODS: We performed a genome-wide association study in a cohort of 835 patients with PsA and 1558 controls from Spain...
March 2019: Annals of the Rheumatic Diseases
#40
JOURNAL ARTICLE
Naiara Naiana Dejani, Allan Botinhon Orlando, Victoria Eugenia Niño, Letícia de Aquino Penteado, Felipe Fortino Verdan, Júlia Miranda Ribeiro Bazzano, Ana Campos Codo, Ana Carolina Guerta Salina, Amanda Correia Saraiva, Matheus Rossi Avelar, Luis Carlos Spolidorio, C Henrique Serezani, Alexandra Ivo Medeiros
Inflammatory responses are terminated by the clearance of dead cells, a process termed efferocytosis. A consequence of efferocytosis is the synthesis of the antiinflammatory mediators TGF-β, PGE2 , and IL-10; however, the efferocytosis of infected cells favors Th17 responses by eliciting the synthesis of TGF-β, IL-6, and IL-23. Recently, we showed that the efferocytosis of apoptotic Escherichia coli -infected macrophages by dendritic cells triggers PGE2 production in addition to pro-Th17 cytokine expression...
September 4, 2018: Proceedings of the National Academy of Sciences of the United States of America
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