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Francisco J DE Figueiredo, Douglas R M Ribeiro
†Codoichthys carnavalii is a clupeomorph fish only found in calcareous concretions of Codó Formation, State of Maranhão. It is known based on three specimens housed in the paleontological collection of the Museu de Ciências da Terra of Departamento Nacional da Produção Mineral, Rio de Janeiro. It was omitted in most of recent cladistic analyses about clupeomorphs. We revisited its anatomy furnishing new data and additional restorations. Furthermore we explored the relationships of †Codoichthys with the computer program TNT based on a matrix with 30 taxa and 60 unordered and unweight characters...
September 2016: Anais da Academia Brasileira de Ciências
Mikael Crona, Paula Codó, Venkateswara Rao Jonna, Anders Hofer, Aristi P Fernandes, Fredrik Tholander
Ribonucleotide Reductase (RNR) is the sole enzyme that catalyzes the reduction of ribonucleotides into deoxyribonucleotides. Even though RNR is a recognized target for antiproliferative molecules, and the main target of the approved drug hydroxyurea, few new leads targeted to this enzyme have been developed. We have evaluated a recently identified set of RNR inhibitors with respect to inhibition of the human enzyme and cellular toxicity. One compound, NSC73735, is particularly interesting; it is specific for leukemia cells and is the first identified compound that hinders oligomerization of the mammalian large RNR subunit...
November 2016: Molecular Oncology
Antonio Julià, Isidoro González, Antonio Fernández-Nebro, Francisco Blanco, Luis Rodriguez, Antonio González, Juan D Cañete, Joan Maymó, Mercedes Alperi-López, Alejandro Olivé, Héctor Corominas, Víctor Martínez-Taboada, Alba Erra, Simón Sánchez-Fernández, Arnald Alonso, Maria Lopez-Lasanta, Raül Tortosa, Laia Codó, Josep Lluis Gelpi, Andres C García-Montero, Jaume Bertranpetit, Devin Absher, S Louis Bridges, Richard M Myers, Jesus Tornero, Sara Marsal
OBJECTIVE: RA patients with serum ACPA have a strong and specific genetic background. The objective of the study was to identify new susceptibility genes for ACPA-positive RA using a genome-wide association approach. METHODS: A total of 924 ACPA-positive RA patients with joint damage in hands and/or feet, and 1524 healthy controls were genotyped in 582 591 single-nucleotide polymorphisms (SNPs) in the discovery phase. In the validation phase, the most significant SNPs in the genome-wide association study representing new candidate loci for RA were tested in an independent cohort of 863 ACPA-positive patients with joint damage and 1152 healthy controls...
June 2016: Rheumatology
Antonio Julià, Francisco Blanco, Benjamín Fernández-Gutierrez, Antonio González, Juan D Cañete, Joan Maymó, Mercedes Alperi-López, Alex Olivè, Héctor Corominas, Víctor Martínez-Taboada, Isidoro González-Álvaro, Antonio Fernandez-Nebro, Alba Erra, Simón Sánchez-Fernández, Arnald Alonso, María López-Lasanta, Raül Tortosa, Laia Codó, Josep Lluis Gelpi, Andrés C García-Montero, Jaume Bertranpetit, Devin Absher, Richard M Myers, Jesús Tornero, Sara Marsal
OBJECTIVE: Rheumatoid factor (RF) is a well-established diagnostic and prognostic biomarker in rheumatoid arthritis (RA). However, ∼20% of RA patients are negative for this anti-IgG antibody. To date, only variation at the HLA-DRB1 gene has been associated with the presence of RF. This study was undertaken to identify additional genetic variants associated with RF positivity. METHODS: A genome-wide association study (GWAS) for RF positivity was performed using an Illumina Quad610 genotyping platform...
June 2016: Arthritis & Rheumatology
Aline Santos Furtado, Flavia Baluz Bezerra de Farias Nunes, Alcione Miranda dos Santos, Arlene de Jesus Mendes Caldas
This study analyzed the spatial and temporal distribution of cases of visceral leishmaniasis in the State of Maranhão in the period from 2000 to 2009. Based on the number of reported cases, thematic maps were prepared to show the evolution of the geographical distribution of the disease in the state. The MCMC method was used for estimating the parameters of the Bayesian model for space-time identification of risk areas. From 2000 to 2009 there were 5389 reported cases of visceral leishmaniasis, distributed in all 18 Regional Health Units in the state, with the highest indices in the cities of Caxias, Imperatriz, Presidente Dutra and Chapadinha...
December 2015: Ciência & Saúde Coletiva
Adam Hospital, Pau Andrio, Cesare Cugnasco, Laia Codo, Yolanda Becerra, Pablo D Dans, Federica Battistini, Jordi Torres, Ramón Goñi, Modesto Orozco, Josep Ll Gelpí
Molecular dynamics simulation (MD) is, just behind genomics, the bioinformatics tool that generates the largest amounts of data, and that is using the largest amount of CPU time in supercomputing centres. MD trajectories are obtained after months of calculations, analysed in situ, and in practice forgotten. Several projects to generate stable trajectory databases have been developed for proteins, but no equivalence exists in the nucleic acids world. We present here a novel database system to store MD trajectories and analyses of nucleic acids...
January 4, 2016: Nucleic Acids Research
Maya V Georgieva, Galal Yahya, Laia Codó, Raúl Ortiz, Laura Teixidó, José Claros, Ricardo Jara, Mònica Jara, Antoni Iborra, Josep Lluís Gelpí, Carme Gallego, Modesto Orozco, Martí Aldea
Protein tagging is widely used in approaches ranging from affinity purification to fluorescence-based detection in live cells. However, an intrinsic limitation of tagging is that the native function of the protein may be compromised or even abolished by the presence of the tag. Here we describe and characterize a set of small, innocuous protein tags (inntags) that we anticipate will find application in a variety of biological techniques.
October 2015: Nature Methods
Violet Oloibiri, Innocent Ufomba, Michael Chys, Wim T M Audenaert, Kristof Demeestere, Stijn W H Van Hulle
The present work investigates the potential of coagulation-flocculation and ozonation to pretreat biologically stabilized landfill leachate before granular activated carbon (GAC) adsorption. Both iron (III) chloride (FeCl3) and polyaluminium chloride (PACl) are investigated as coagulants. Better organic matter removal is observed when leachate was treated with FeCl3. At a dose of 1mg FeCl3/mg CODo (CODo: initial COD content), the COD and α254 removal was 66% and 88%, respectively. Dosing 1mg PACl/mg CODo resulted in 44% COD and 72% α254 removal...
September 2015: Waste Management
Antonio Julià, José Antonio Pinto, Jordi Gratacós, Rubén Queiró, Carlos Ferrándiz, Eduardo Fonseca, Carlos Montilla, Juan Carlos Torre-Alonso, Lluís Puig, José Javier Pérez Venegas, Antonio Fernández Nebro, Emilia Fernández, Santiago Muñoz-Fernández, Esteban Daudén, Carlos González, Daniel Roig, José Luís Sánchez Carazo, Pedro Zarco, Alba Erra, José Luís López Estebaranz, Jesús Rodríguez, David Moreno Ramírez, Pablo de la Cueva, Francisco Vanaclocha, Enrique Herrera, Santos Castañeda, Esteban Rubio, Georgina Salvador, César Díaz-Torné, Ricardo Blanco, Alfredo Willisch Domínguez, José Antonio Mosquera, Paloma Vela, Jesús Tornero, Simón Sánchez-Fernández, Héctor Corominas, Julio Ramírez, María López-Lasanta, Raül Tortosa, Nuria Palau, Arnald Alonso, Andrés C García-Montero, Josep Lluís Gelpí, Laia Codó, Kenneth Day, Devin Absher, Richard M Myers, Juan D Cañete, Sara Marsal
OBJECTIVE: Copy number variants (CNVs) have been associated with the risk to develop multiple autoimmune diseases. Our objective was to identify CNVs associated with the risk to develop psoriatic arthritis (PsA) using a genome-wide analysis approach. METHODS: A total of 835 patients with PsA and 1498 healthy controls were genotyped for CNVs using the Illumina HumanHap610 BeadChip genotyping platform. Genomic CNVs were characterised using CNstream analysis software and analysed for association using the χ(2) test...
October 2015: Annals of the Rheumatic Diseases
Patrick Roth, Andreas Keller, Jörg D Hoheisel, Paula Codo, Andrea S Bauer, Christina Backes, Petra Leidinger, Eckart Meese, Eckhard Thiel, Agnieszka Korfel, Michael Weller
Despite improved therapeutic regimens, primary CNS lymphoma (PCNSL) remains a therapeutic challenge. A prognostic classification of PCNSL patients may represent an important step towards optimised patient-adapted therapy. However, only higher age and low Karnofsky Performance Status (KPS) have repeatedly been reported to be associated with shorter overall survival (OS). Here we characterised microRNA (miRNA) fingerprints in the blood of PCNSL patients with short-term survival (STS) versus long-term survival (LTS) to assess their potential as novel prognostic biomarkers...
February 2015: European Journal of Cancer
Paula Codo, Michael Weller, Gunter Meister, Emese Szabo, Alexander Steinle, Marietta Wolter, Guido Reifenberger, Patrick Roth
Malignant gliomas are intrinsic brain tumors with a dismal prognosis. They are well-adapted to hypoxic conditions and poorly immunogenic. NKG2D is one of the major activating receptors of natural killer (NK) cells and binds to several ligands (NKG2DL). Here we evaluated the impact of miRNA on the expression of NKG2DL in glioma cells including stem-like glioma cells. Three of the candidate miRNA predicted to target NKG2DL were expressed in various glioma cell lines as well as in glioblastomas in vivo: miR-20a, miR-93 and miR-106b...
September 15, 2014: Oncotarget
Cristina Borim Codo Dias Gonçalves, Ivani Novato Silva, Mariella Guarino Tanure, Magda Bahia
OBJECTIVE: To estimate the prevalence of celiac disease (CD) in children and adolescents with type 1 diabetes mellitus (T1DM) treated in the Children's Division of Endocrinology, at the Universidade Federal de Minas Gerais Hospital das Clínicas. SUBJECTS AND METHODS: Children and adolescents diagnosed with T1DM, aged 0 to 18 year, were included in this study performed from March 1999 to April 2009. All patients were screened for CD at their first visit and, again, annually...
July 2013: Arquivos Brasileiros de Endocrinologia e Metabologia
Rosa Sánchez-Casas, Pilar Ferré, Josep Demestre, Teófilo García-Chico, José E García-Albea
The study presented in this paper aimed to investigate the pattern of semantic priming effects, under masked and unmasked conditions, in the lexical decision task, manipulating type of semantic relation and associative strength. Three different kinds of word relations were examined in two experiments: only-semantically related words [e.g., codo (elbow)-rodilla (knee)] and semantic/associative related words with strong [e.g., mesa (table)-silla (chair) and weak association strength [e.g., sapo (toad)-rana (frog)]...
November 2012: Spanish Journal of Psychology
Antonio Julià, Eugeni Domènech, Elena Ricart, Raül Tortosa, Valle García-Sánchez, Javier P Gisbert, Pilar Nos Mateu, Ana Gutiérrez, Fernando Gomollón, Juan Luís Mendoza, Esther Garcia-Planella, Manuel Barreiro-de Acosta, Fernando Muñoz, Maribel Vera, Cristina Saro, Maria Esteve, Montserrat Andreu, Arnald Alonso, María López-Lasanta, Laia Codó, Josep Lluís Gelpí, Andres C García-Montero, Jaume Bertranpetit, Devin Absher, Julián Panés, Sara Marsal
OBJECTIVE: Genome-wide association studies (GWAS) have identified multiple risk loci for Crohn's disease (CD). However, the cumulative risk exerted by these loci is low, and the likelihood that additional, as-yet undiscovered loci contribute to the risk of CD is very high. We performed a GWAS on a southern European population to identify new CD risk loci. DESIGN: We genotyped 620 901 genome markers on 1341 CD patients and 1518 controls from Spain. The top association signals representing new candidate risk loci were subsequently analysed in an independent replication cohort of 1365 CD patients and 1396 controls...
October 2013: Gut
M H Silva, M D S B Nascimento, F S Leonardo, J M M Rebêlo, S R F Pereira
Entomological surveys in the state of Maranhão have recorded morphologically distinct populations of Lutzomyia longipalpis (Lutz & Neiva). Some populations have one pair of spots (1S) on the fourth tergite, while others have two pairs (2S) on the third and fourth tergites of males. In the present study we investigated the degree of genetic polymorphism among four populations in the municipalities of Caxias, Codó and Raposa, in the state of Maranhão, Brazil, by using RAPD (Random Amplified Polymorphic DNA) markers...
July 2011: Neotropical Entomology
Tue Jollo Nazima, Carla Regina Bianchi Codo, Irani Aparecida Dalla Costa Paes, Greicelene Aparecida Hespanhol Bassinello
Theater could be considered as a dramatic game and as an educational method, because it reaches the child as a whole, encompassing creativity and learning through entertainment. This article is a report of nursing students' experience in guiding children through theater in a public nursery located in the interior of São Paulo state. The objective was to report on the benefits of using theatre with children. The methodology to develop the study was a dialogue based on literature review articulated with the account of experience...
March 2008: Revista Gaúcha de Enfermagem
Li Ge, Hong-Shu Sui, Guo-Cheng Lan, Na Liu, Jun-Zuo Wang, Jing-He Tan
OBJECTIVE: To study the mechanisms by which cumulus cells (CCs) promote oocyte maturation by observing the effect of removing the cumulus oophorus on nuclear and cytoplasmic events during in vitro maturation. DESIGN: Experimental animal study. SETTING: Academic institution. ANIMAL(S): Mice of the Kun-ming breed. INTERVENTION(S): Cumulus-free oocytes were cultured alone (DOs) or with a CC monolayer (coDOs), and the nuclear and cytoplasmic events were compared with those of oocytes matured in vivo or in vitro with the cumulus intact (COCs)...
December 2008: Fertility and Sterility
Jackson D S Paz, Dilce F Rossetti
An original and detailed study focusing the petrography of evaporites from the Late Aptian deposits exposed in the eastern and southern São Luís-Grajaú Basin is presented herein, with the attempt of distinguishing between primary and secondary evaporites, and reconstructing their post-depositional evolution. Seven evaporites phases were recognized: 1. chevron gypsum; 2. nodular to lensoidal gypsum or anhydrite; 3. fibrous to acicular gypsum; 4. mosaic gypsum; 5. brecciated gypsum or gypsarenite; 6. pseudo-nodular anhydrite or gypsum; and 7...
September 2006: Anais da Academia Brasileira de Ciências
José Côdo Albino Dias, Betânia Silva de Moura, Erika Figueiredo Gomes, Guilherme Borim Mirachi, Otto Metzger Filho, Cristina Borim Côdo Dias
Thyrotoxic hypokalemic periodic paralysis (THPP) is a rare hyperthyroidism complication much more frequent in Asians and Caucasians. We present 3 cases of THPP occurring in Brazilian male patients with 28 years old (y) (Case 1), 29 y (Case 2) and 60 y (Case 3), respectively. They were admitted following an episode of flacid paralysis of extremities. Whereas case 1 reported recurring episodes of paralysis crises, cases 2 and 3 reported only one episode. Signs and symptoms of thyrotoxicosis, such as weigh loss, diaphoresis, extremities tremor, palpitation and mild diffuse goiter were present in the first case; while the second case only presented ophthalmopathy and the third patient referred that 2 years before his admission he presented an episode of cardiac arrhythmia but did not have thyroid function evaluation at that time...
December 2004: Arquivos Brasileiros de Endocrinologia e Metabologia
Idil Arslan-Alaton, Ozden Seremet
Biotreated textile wastewater (CODo = 248 mg L(-1); TOCo = 58 mg L(-1); A620 = 0.007 cm(-1); A525 = 0.181 cm(-1); A436 = 0.198 cm(-1)) was subjected to advanced treatment with ozonation, granular activated carbon (GAC) adsorption in serial and simultaneous applications. Experiments were conducted to investigate the effects of applied ozone dose, ozone absorption rate, specific ozone absorption efficiency, GAC dose, and reaction pH on the treatment performance of the selected tertiary treatment scheme. In separate experiments, the impact of virgin GAC ozonation on its adsorptive capacity for biotreated and biotreated + ozonated textile effluent was also investigated...
2004: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
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