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Christoph Heining, Peter Horak, Sebastian Uhrig, Paula L Codo, Barbara Klink, Barbara Hutter, Martina Fröhlich, David Bonekamp, Daniela Richter, Katja Steiger, Roland Penzel, Volker Endris, Karl Roland Ehrenberg, Stephanie Frank, Kortine Kleinheinz, Umut H Toprak, Matthias Schlesner, Ranadip Mandal, Lothar Schulz, Helmut Lambertz, Sebastian Fetscher, Michael Bitzer, Nisar P Malek, Marius S Horger, Nathalia A Giese, Oliver Strobel, Thilo Hackert, Christoph Springfeld, Lars Feuerbach, Frank Bergmann, Evelin Schröck, Christof von Kalle, Wilko Weichert, Claudia Scholl, Claudia R Ball, Albrecht Stenzinger, Benedikt Brors, Stefan Fröhling, Hanno Glimm
We used whole-genome and transcriptome sequencing to identify clinically actionable genomic alterations in young adults with pancreatic ductal adenocarcinoma (PDAC). Molecular characterization of 17 PDAC patients enrolled in a precision oncology program revealed gene fusions amenable to pharmacologic inhibition by small-molecule tyrosine kinase inhibitors in all patients with KRAS wild-type (KRASwt) tumors (4 of 17). These alterations included recurrent NRG1 rearrangements predicted to drive PDAC development through aberrant ERBB receptor-mediated signaling, and pharmacologic ERBB inhibition resulted in clinical improvement and remission of liver metastases in two patients with NRG1-rearranged tumors that had proved resistant to standard treatment...
May 25, 2018: Cancer Discovery
Carla Regina Bianchi Codo, Jamil Pedro de Siqueira Caldas, Rafaella Regina Alves Peixoto, Vitor Lacerda Sanches, Tamara Cristina Guiraldelo, Solange Cadore, Sérgio Tadeu Martins Marba
OBJECTIVE: To determine and compare the concentrations of electrolytes and minerals in three different types of maternal milk samples: term donor milk before pasteurization, term donor milk after pasteurization and raw milk of mothers of preterm newborns at bedside. METHODS: Descriptive cross-sectional study. Concentrations of calcium (Ca), phosphorous (P), magnesium (Mg), sodium (Na) and potassium (K) were measured in random samples of three human breast milk groups...
February 22, 2018: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
Prajakta Khalkar, Hani Abdulkadir Ali, Paula Codó, Nuria Díaz Argelich, Anni Martikainen, Mohsen Karimi Arzenani, Sören Lehmann, Julian Walfridsson, Johanna Ungerstedt, Aristi P Fernandes
Selenium compounds have emerged as promising chemotherapeutic agents with proposed epigenetic effects, however the mechanisms and downstream effects are yet to be studied. Here we assessed the effects of the inorganic selenium compound selenite and the organic form methylseleninic acid (MSA) in a leukemic cell line K562, on active (histone H3 lysine 9 acetylation, H3K9ac and histone H3 lysine 4 tri-methylation, H3K4me3) and repressive (histone H3 lysine 9 tri-methylation, H3K9me3) histone marks by Chromatin immunoprecipitation followed by DNA sequencing (ChIP-Seq)...
March 2018: Free Radical Biology & Medicine
José Luis Sandoval-Gutiérrez
Delgado-García, et al. presentan una disertación amplia, con revisión histórica profunda, de la lesión torácica que sufrió Alejandro Magno por el disparo de una saeta de dos codos de largo (88 cm) en la batalla contra los malios, donde a través de diversas narraciones se ha considerado que sufrió un neumotórax y que debido a la gravedad de la lesión sus médicos decidieron retirar el objeto punzocortante, obteniéndose aire y sangre posextracción; el emperador perdió el estado de alerta, recuperándose posteriormente la herida y permitiéndole montar a caballo a los pocos días...
November 2017: Gaceta Médica de México
Robin Fernandez-Hilario, Robert Arteaga
Raputia codo-pozuzoensis Rob. Fernandez & Arteaga, sp. nov. (Galipeinae, Rutaceae), a new species endemic to the Huanuco region, in the Selva Central of Peru, is described and illustrated here. The new species differs from other species of Raputia by the combination of 5-7-foliolate leaves (a new characteristic for the genus) and longer petioles. A key to the four Peruvian species of Raputia is presented.
2017: PhytoKeys
Armando González-Stuart, José O Rivera
The Dietary Supplements and Health Education Act (DSHEA), passed by the United States Congress in October of 1994, defines herbal products as nutritional supplements, not medications. This opened the market for diverse products made from plants, including teas, extracts, essential oils, and syrups. Mexico and the United States share an extensive border, where diverse herbal products are available to the public without a medical prescription. Research undertaken in the neighboring cities of Ciudad Juarez, Mexico, and El Paso, Texas, USA, shows the use of herbs is higher in this border area compared to the rest of the United States...
May 4, 2018: Journal of Dietary Supplements
Dissou Affolabi, N'Dira Sanoussi, Sergio Codo, Fréderic Sogbo, Prudence Wachinou, Faridath Massou, Aderemi Kehinde, Séverin Anagonou
BACKGROUND: Molecular studies on tuberculosis (TB) are rare in low-resource countries like Benin, where data on molecular study on previously treated TB cases is unavailable. MATERIALS AND METHODS: From January to December 2014, all smear- and culture-positive previously treated pulmonary TB patients from all TB clinics were systematically recruited. Drug susceptibility testing and spoligotyping were performed on all isolates. RESULTS: Of the 100 patients recruited, 71 (71...
2017: Canadian Journal of Infectious Diseases & Medical Microbiology
Alberto Ramos-Silva, Faviola Tavares-Carreón, Mario Figueroa, Susana De la Torre-Zavala, Argel Gastelum-Arellanez, Aída Rodríguez-García, Luis J Galán-Wong, Hamlet Avilés-Arnaut
BACKGROUND: Thevetia peruviana (Pers.) K. Schum or Cascabela peruviana (L.) Lippold (commonly known as ayoyote, codo de fraile, lucky nut, or yellow oleander), native to Mexico and Central America, is a medicinal plant used traditionally to cure diseases like ulcers, scabies, hemorrhoids and dissolve tumors. The purpose of this study was to evaluate the cytotoxic, antiproliferative and apoptotic activity of methanolic extract of T. peruviana fruits on human cancer cell lines. METHODS: The cytotoxic activity of T...
May 2, 2017: BMC Complementary and Alternative Medicine
Francisco J DE Figueiredo, Douglas R M Ribeiro
†Codoichthys carnavalii is a clupeomorph fish only found in calcareous concretions of Codó Formation, State of Maranhão. It is known based on three specimens housed in the paleontological collection of the Museu de Ciências da Terra of Departamento Nacional da Produção Mineral, Rio de Janeiro. It was omitted in most of recent cladistic analyses about clupeomorphs. We revisited its anatomy furnishing new data and additional restorations. Furthermore we explored the relationships of †Codoichthys with the computer program TNT based on a matrix with 30 taxa and 60 unordered and unweight characters...
September 2016: Anais da Academia Brasileira de Ciências
Mikael Crona, Paula Codó, Venkateswara Rao Jonna, Anders Hofer, Aristi P Fernandes, Fredrik Tholander
Ribonucleotide Reductase (RNR) is the sole enzyme that catalyzes the reduction of ribonucleotides into deoxyribonucleotides. Even though RNR is a recognized target for antiproliferative molecules, and the main target of the approved drug hydroxyurea, few new leads targeted to this enzyme have been developed. We have evaluated a recently identified set of RNR inhibitors with respect to inhibition of the human enzyme and cellular toxicity. One compound, NSC73735, is particularly interesting; it is specific for leukemia cells and is the first identified compound that hinders oligomerization of the mammalian large RNR subunit...
November 2016: Molecular Oncology
Antonio Julià, Isidoro González, Antonio Fernández-Nebro, Francisco Blanco, Luis Rodriguez, Antonio González, Juan D Cañete, Joan Maymó, Mercedes Alperi-López, Alejandro Olivé, Héctor Corominas, Víctor Martínez-Taboada, Alba Erra, Simón Sánchez-Fernández, Arnald Alonso, Maria Lopez-Lasanta, Raül Tortosa, Laia Codó, Josep Lluis Gelpi, Andres C García-Montero, Jaume Bertranpetit, Devin Absher, S Louis Bridges, Richard M Myers, Jesus Tornero, Sara Marsal
OBJECTIVE: RA patients with serum ACPA have a strong and specific genetic background. The objective of the study was to identify new susceptibility genes for ACPA-positive RA using a genome-wide association approach. METHODS: A total of 924 ACPA-positive RA patients with joint damage in hands and/or feet, and 1524 healthy controls were genotyped in 582 591 single-nucleotide polymorphisms (SNPs) in the discovery phase. In the validation phase, the most significant SNPs in the genome-wide association study representing new candidate loci for RA were tested in an independent cohort of 863 ACPA-positive patients with joint damage and 1152 healthy controls...
June 2016: Rheumatology
Antonio Julià, Francisco Blanco, Benjamín Fernández-Gutierrez, Antonio González, Juan D Cañete, Joan Maymó, Mercedes Alperi-López, Alex Olivè, Héctor Corominas, Víctor Martínez-Taboada, Isidoro González-Álvaro, Antonio Fernandez-Nebro, Alba Erra, Simón Sánchez-Fernández, Arnald Alonso, María López-Lasanta, Raül Tortosa, Laia Codó, Josep Lluis Gelpi, Andrés C García-Montero, Jaume Bertranpetit, Devin Absher, Richard M Myers, Jesús Tornero, Sara Marsal
OBJECTIVE: Rheumatoid factor (RF) is a well-established diagnostic and prognostic biomarker in rheumatoid arthritis (RA). However, ∼20% of RA patients are negative for this anti-IgG antibody. To date, only variation at the HLA-DRB1 gene has been associated with the presence of RF. This study was undertaken to identify additional genetic variants associated with RF positivity. METHODS: A genome-wide association study (GWAS) for RF positivity was performed using an Illumina Quad610 genotyping platform...
June 2016: Arthritis & Rheumatology
Aline Santos Furtado, Flavia Baluz Bezerra de Farias Nunes, Alcione Miranda dos Santos, Arlene de Jesus Mendes Caldas
This study analyzed the spatial and temporal distribution of cases of visceral leishmaniasis in the State of Maranhão in the period from 2000 to 2009. Based on the number of reported cases, thematic maps were prepared to show the evolution of the geographical distribution of the disease in the state. The MCMC method was used for estimating the parameters of the Bayesian model for space-time identification of risk areas. From 2000 to 2009 there were 5389 reported cases of visceral leishmaniasis, distributed in all 18 Regional Health Units in the state, with the highest indices in the cities of Caxias, Imperatriz, Presidente Dutra and Chapadinha...
December 2015: Ciência & Saúde Coletiva
Adam Hospital, Pau Andrio, Cesare Cugnasco, Laia Codo, Yolanda Becerra, Pablo D Dans, Federica Battistini, Jordi Torres, Ramón Goñi, Modesto Orozco, Josep Ll Gelpí
Molecular dynamics simulation (MD) is, just behind genomics, the bioinformatics tool that generates the largest amounts of data, and that is using the largest amount of CPU time in supercomputing centres. MD trajectories are obtained after months of calculations, analysed in situ, and in practice forgotten. Several projects to generate stable trajectory databases have been developed for proteins, but no equivalence exists in the nucleic acids world. We present here a novel database system to store MD trajectories and analyses of nucleic acids...
January 4, 2016: Nucleic Acids Research
Maya V Georgieva, Galal Yahya, Laia Codó, Raúl Ortiz, Laura Teixidó, José Claros, Ricardo Jara, Mònica Jara, Antoni Iborra, Josep Lluís Gelpí, Carme Gallego, Modesto Orozco, Martí Aldea
Protein tagging is widely used in approaches ranging from affinity purification to fluorescence-based detection in live cells. However, an intrinsic limitation of tagging is that the native function of the protein may be compromised or even abolished by the presence of the tag. Here we describe and characterize a set of small, innocuous protein tags (inntags) that we anticipate will find application in a variety of biological techniques.
October 2015: Nature Methods
Violet Oloibiri, Innocent Ufomba, Michael Chys, Wim T M Audenaert, Kristof Demeestere, Stijn W H Van Hulle
The present work investigates the potential of coagulation-flocculation and ozonation to pretreat biologically stabilized landfill leachate before granular activated carbon (GAC) adsorption. Both iron (III) chloride (FeCl3) and polyaluminium chloride (PACl) are investigated as coagulants. Better organic matter removal is observed when leachate was treated with FeCl3. At a dose of 1mg FeCl3/mg CODo (CODo: initial COD content), the COD and α254 removal was 66% and 88%, respectively. Dosing 1mg PACl/mg CODo resulted in 44% COD and 72% α254 removal...
September 2015: Waste Management
Antonio Julià, José Antonio Pinto, Jordi Gratacós, Rubén Queiró, Carlos Ferrándiz, Eduardo Fonseca, Carlos Montilla, Juan Carlos Torre-Alonso, Lluís Puig, José Javier Pérez Venegas, Antonio Fernández Nebro, Emilia Fernández, Santiago Muñoz-Fernández, Esteban Daudén, Carlos González, Daniel Roig, José Luís Sánchez Carazo, Pedro Zarco, Alba Erra, José Luís López Estebaranz, Jesús Rodríguez, David Moreno Ramírez, Pablo de la Cueva, Francisco Vanaclocha, Enrique Herrera, Santos Castañeda, Esteban Rubio, Georgina Salvador, César Díaz-Torné, Ricardo Blanco, Alfredo Willisch Domínguez, José Antonio Mosquera, Paloma Vela, Jesús Tornero, Simón Sánchez-Fernández, Héctor Corominas, Julio Ramírez, María López-Lasanta, Raül Tortosa, Nuria Palau, Arnald Alonso, Andrés C García-Montero, Josep Lluís Gelpí, Laia Codó, Kenneth Day, Devin Absher, Richard M Myers, Juan D Cañete, Sara Marsal
OBJECTIVE: Copy number variants (CNVs) have been associated with the risk to develop multiple autoimmune diseases. Our objective was to identify CNVs associated with the risk to develop psoriatic arthritis (PsA) using a genome-wide analysis approach. METHODS: A total of 835 patients with PsA and 1498 healthy controls were genotyped for CNVs using the Illumina HumanHap610 BeadChip genotyping platform. Genomic CNVs were characterised using CNstream analysis software and analysed for association using the χ(2) test...
October 2015: Annals of the Rheumatic Diseases
Patrick Roth, Andreas Keller, Jörg D Hoheisel, Paula Codo, Andrea S Bauer, Christina Backes, Petra Leidinger, Eckart Meese, Eckhard Thiel, Agnieszka Korfel, Michael Weller
Despite improved therapeutic regimens, primary CNS lymphoma (PCNSL) remains a therapeutic challenge. A prognostic classification of PCNSL patients may represent an important step towards optimised patient-adapted therapy. However, only higher age and low Karnofsky Performance Status (KPS) have repeatedly been reported to be associated with shorter overall survival (OS). Here we characterised microRNA (miRNA) fingerprints in the blood of PCNSL patients with short-term survival (STS) versus long-term survival (LTS) to assess their potential as novel prognostic biomarkers...
February 2015: European Journal of Cancer
Paula Codo, Michael Weller, Gunter Meister, Emese Szabo, Alexander Steinle, Marietta Wolter, Guido Reifenberger, Patrick Roth
Malignant gliomas are intrinsic brain tumors with a dismal prognosis. They are well-adapted to hypoxic conditions and poorly immunogenic. NKG2D is one of the major activating receptors of natural killer (NK) cells and binds to several ligands (NKG2DL). Here we evaluated the impact of miRNA on the expression of NKG2DL in glioma cells including stem-like glioma cells. Three of the candidate miRNA predicted to target NKG2DL were expressed in various glioma cell lines as well as in glioblastomas in vivo: miR-20a, miR-93 and miR-106b...
September 15, 2014: Oncotarget
Cristina Borim Codo Dias Gonçalves, Ivani Novato Silva, Mariella Guarino Tanure, Magda Bahia
OBJECTIVE: To estimate the prevalence of celiac disease (CD) in children and adolescents with type 1 diabetes mellitus (T1DM) treated in the Children's Division of Endocrinology, at the Universidade Federal de Minas Gerais Hospital das Clínicas. SUBJECTS AND METHODS: Children and adolescents diagnosed with T1DM, aged 0 to 18 year, were included in this study performed from March 1999 to April 2009. All patients were screened for CD at their first visit and, again, annually...
July 2013: Arquivos Brasileiros de Endocrinologia e Metabologia
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