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https://www.readbyqxmd.com/read/28926963/broad-and-inconsistent-muscle-food-classification-is-problematic-for-dietary-guidance-in-the-u-s
#1
REVIEW
Cody L Gifford, Lauren E O'Connor, Wayne W Campbell, Dale R Woerner, Keith E Belk
Dietary recommendations regarding consumption of muscle foods, such as red meat, processed meat, poultry or fish, largely rely on current dietary intake assessment methods. This narrative review summarizes how U.S. intake values for various types of muscle foods are grouped and estimated via methods that include: (1) food frequency questionnaires; (2) food disappearance data from the U.S. Department of Agriculture Economic Research Service; and (3) dietary recall information from the National Health and Nutrition Examination Survey data...
September 16, 2017: Nutrients
https://www.readbyqxmd.com/read/28923933/longitudinal-identification-of-clinically-distinct-neurophenotypes-in-young-children-with-fragile-x-syndrome
#2
Jennifer L Bruno, David Romano, Paul Mazaika, Amy A Lightbody, Heather Cody Hazlett, Joseph Piven, Allan L Reiss
Fragile X syndrome (FXS), due to mutations of the FMR1 gene, is the most common known inherited cause of developmental disability. The cognitive, behavioral, and neurological phenotypes observed in affected individuals can vary considerably, making it difficult to predict outcomes and determine the need for interventions. We sought to examine early structural brain growth as a potential marker for identification of clinically meaningful subgroups. Participants included 42 very young boys with FXS who completed a T1-weighted anatomical MRI and cognitive/behavioral assessment at two longitudinal time points, with mean ages of 2...
September 18, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28922740/a-conserved-dggk-motif-is-essential-for-the-function-of-the-pglb-oligosaccharyltransferase-from-campylobacter-jejuni
#3
Yasmin Barre, Harald Nothaft, Cody Thomas, Xin Liu, Jianjun Li, Kenneth K S Ng, Christine M Szymanski
In Campylobacter jejuni, the PglB oligosaccharyltransferase catalyzes the transfer of a heptasaccharide from a lipid donor to asparagine within the D/E-X1-N-X2-S/T sequon (X1,2 ≠ P) or releases this heptasaccharide as free oligosaccharides (fOS). Using available crystal structures and sequence alignments, we identified a DGGK motif near the active site of PglB that is conserved among all Campylobacter species. We demonstrate that amino acid substitutions in the aspartate and lysine residues result in loss of protein glycosylation in the heterologous Escherichia coli system...
October 1, 2017: Glycobiology
https://www.readbyqxmd.com/read/28915941/paper-spray-and-kendrick-mass-defect-analysis-of-block-and-random-ethylene-oxide-propylene-oxide-copolymers
#4
Robert B Cody, Thierry Fouquet
Paper spray ionization coupled with a high-resolution time-of-flight mass spectrometer was applied to the analysis of 13 block and 2 random ethylene oxide/propylene oxide (EO/PO) copolymers as well as to standard samples of poly(ethylene oxide) and poly(propylene oxide) homopolymers. Paper spray mass spectra could be obtained rapidly and, unlike electrospray ionization, were not subject to contamination and sample carryover. For comparison, polyether samples were also measured on a MALDI/TOF system with ultrahigh mass resolving power...
October 9, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28915577/vorinostat-suppresses-hypoxia-signaling-by-modulating-nuclear-translocation-of-hypoxia-inducible-factor-1-alpha
#5
Chao Zhang, Chunzhang Yang, Michael J Feldman, Herui Wang, Ying Pang, Dominic M Maggio, Dongwang Zhu, Cody L Nesvick, Pauline Dmitriev, Petra Bullova, Prashant Chittiboina, Roscoe O Brady, Karel Pacak, Zhengping Zhuang
Histone deacetylase inhibitors (HDACis) are a potent class of tumor-suppressive agents traditionally believed to exert their effects through loosening tightly-wound chromatin resulting in de-inhibition of various tumor suppressive genes. Recent literature however has shown altered intratumoral hypoxia signaling with HDACi administration not attributable to changes in chromatin structure. We sought to determine the precise mechanism of HDACi-mediated hypoxia signaling attenuation using vorinostat (SAHA), an FDA-approved class I/IIb/IV HDACi...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28913666/quantitative-modeling-of-the-dynamics-and-intracellular-trafficking-of-far-red-light-activatable-prodrugs-implications-in-stimuli-responsive-drug-delivery-system
#6
Mengjie Li, Pritam Thapa, Pallavi Rajaputra, Moses Bio, Cody J Peer, William D Figg, Youngjae You, Sukyung Woo
The combination of photodynamic therapy (PDT) with anti-tumor agents is a complimentary strategy to treat local cancers. We developed a unique photosensitizer (PS)-conjugated paclitaxel (PTX) prodrug in which a PS is excited by near-infrared wavelength light to site-specifically release PTX while generating singlet oxygen (SO) to effectively kill cancer cells with both PTX and SO. The aim of the present study was to identify the determinants influencing the combined efficacy of this light-activatable prodrug, especially the bystander killing effects from released PTX...
September 14, 2017: Journal of Pharmacokinetics and Pharmacodynamics
https://www.readbyqxmd.com/read/28910576/impact-of-staphylococcus-aureus-regulatory-mutations-that-modulate-biofilm-formation-in-the-usa300-strain-lac-on-virulence-in-a-murine-bacteremia-model
#7
Joseph S Rom, Danielle N Atwood, Karen E Beenken, Daniel G Meeker, Allister J Loughran, Horace J Spencer, Tamara L Lantz, Mark S Smeltzer
Staphylococcus aureus causes acute and chronic forms of infection, the latter often associated with formation of a biofilm. It has previously been demonstrated that mutation of atl, codY, rot, sarA, and sigB limits biofilm formation in the USA300 strain LAC while mutation of agr, fur, and mgrA has the opposite effect. Here we used a murine sepsis model to assess the impact of these same loci in acute infection. Mutation of agr, atl, and fur had no impact on virulence, while mutation of mgrA and rot increased virulence...
September 14, 2017: Virulence
https://www.readbyqxmd.com/read/28903503/identifying-gaps-in-respiratory-syncytial-virus-disease-epidemiology-in-the-united-states-prior-to-the-introduction-of-vaccines
#8
Lindsay Kim, Brian Rha, Jon S Abramson, Larry J Anderson, Carrie L Byington, Grace L Chen, John DeVincenzo, Kathryn M Edwards, Janet A Englund, Ann R Falsey, Marie R Griffin, Ruth A Karron, Karen G Martin, H Cody Meissner, Flor M Munoz, Andrew T Pavia, Pedro A Piedra, William Schaffner, Eric A F Simões, Rosalyn Singleton, H Keipp Talbot, Edward E Walsh, Jane R Zucker, Susan I Gerber
Respiratory syncytial virus (RSV) causes lower respiratory tract illness frequently. No effective antivirals or vaccines for RSV are approved for use in the United States; however, there are at least 50 vaccines and monoclonal antibody products in development, with those targeting older adults and pregnant women (to protect young infants) in phase 2 and 3 clinical trials. Unanswered questions regarding RSV epidemiology need to be identified and addressed prior to RSV vaccine introduction to guide the measurement of impact and future recommendations...
September 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28899300/a-living-science-a-living-journal
#9
William K Cody
No abstract text is available yet for this article.
January 2017: Nursing Science Quarterly
https://www.readbyqxmd.com/read/28898986/building-a-new-transfusion-service
#10
John R Hess, Brenda K Hayden, Virginia G Cruz-Cody, Max J Louzon, Erin E Tuott, Nina E Sen, Roxann Gary, Patrick J Ramos, Jennifer A Daniel-Johnson, Ryan A Metcalf, Monica B Pagano
Objectives: For over 60 years, Harborview Medical Center (HMC) in Seattle has received its blood components and pretransfusion testing from a centralized transfusion service operated by the regional blood supplier. In 2011, a hospital-based transfusion service (HBTS) was activated. Methods: After 5 years of operation, we evaluated the effects of the HBTS by reviewing records of hospital blood use, quality system events, blood product delivery times, and costs. Furthermore, the effects of in-house expertise on laboratory medicine resident and medical laboratory scientist student training, as well as regulatory and accrediting agency concerns, were reviewed...
August 1, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28894646/canopy-soil-bacterial-communities-altered-by-severing-host-tree-limbs
#11
Cody R Dangerfield, Nalini M Nadkarni, William J Brazelton
Trees of temperate rainforests host a large biomass of epiphytic plants, which are associated with soils formed in the forest canopy. Falling of epiphytic material results in the transfer of carbon and nutrients from the canopy to the forest floor. This study provides the first characterization of bacterial communities in canopy soils enabled by high-depth environmental sequencing of 16S rRNA genes. Canopy soil included many of the same major taxonomic groups of Bacteria that are also found in ground soil, but canopy bacterial communities were lower in diversity and contained different operational taxonomic units...
2017: PeerJ
https://www.readbyqxmd.com/read/28892574/identification-of-a-novel-interspecific-hybrid-yeast-from-a-metagenomic-spontaneously-inoculated-beer-sample-using-hi-c
#12
Caiti Smukowski Heil, Joshua N Burton, Ivan Liachko, Anne Friedrich, Noah A Hanson, Cody L Morris, Joseph Schacherer, Jay Shendure, James H Thomas, Maitreya J Dunham
Interspecific hybridization is a common mechanism enabling genetic diversification and adaptation; however, the detection of hybrid species has been quite difficult. The identification of microbial hybrids is made even more complicated, as most environmental microbes are resistant to culturing and must be studied in their native mixed communities. We have previously adapted the chromosome conformation capture method Hi-C to the assembly of genomes from mixed populations. Here, we show the method's application in assembling genomes directly from an uncultured, mixed population from a spontaneously inoculated beer sample...
September 11, 2017: Yeast
https://www.readbyqxmd.com/read/28889004/quantitative-vascular-neuroimaging-of-the-rat-brain-using-superparamagnetic-nanoparticles-new-insights-on-vascular-organization-and-brain-function
#13
Codi A Gharagouzloo, Liam Timms, Ju Qiao, Zihang Fang, Joseph Nneji, Aniket Pandya, Praveen Kulkarni, Anne L van de Ven, Craig Ferris, Srinivas Sridhar
A method called Quantitative Ultra-Short Time-to-Echo Contrast Enhanced (QUTE-CE) Magnetic Resonance Imaging (MRI) which utilizes superparamagnetic iron oxide nanoparticles (SPIONs) as a contrast agent to yield positive contrast angiograms with high clarity and definition is applied to the whole live rat brain. QUTE-CE MRI intensity data are particularly well suited for measuring quantitative cerebral blood volume (qCBV). A global map of qCBV in the awake resting-state with unprecedented detail was created via application of a 3D MRI rat brain atlas with 173 segmented and annotated brain areas...
September 6, 2017: NeuroImage
https://www.readbyqxmd.com/read/28888953/attentional-control-underlies-the-perceptual-load-effect-evidence-from-voxel-wise-degree-centrality-and-resting-state-functional-connectivity
#14
Shouhang Yin, Lu Liu, Jinfeng Tan, Cody Ding, Dezhong Yao, Antao Chen
The fact that interference from peripheral distracting information can be reduced in high perceptual load tasks has been widely demonstrated in previous research. The modulation from the perceptual load is known as perceptual load effect (PLE). Previous functional magnetic resonance imaging (fMRI) studies on perceptual load have reported the brain areas implicated in attentional control. To date, the contribution of attentional control to PLE and the relationship between the organization of functional connectivity and PLE are still poorly understood...
September 6, 2017: Neuroscience
https://www.readbyqxmd.com/read/28885961/effectiveness-of-ice-sheet-cooling-following-exertional-hyperthermia
#15
Cory L Butts, Debora L Spisla, J D Adams, Cody R Smith, Kathleen M Paulsen, Aaron R Caldwell, Matthew S Ganio, Brendon P McDermott
BACKGROUND: The procedure of wrapping a heat casualty in ice-water soaked bed sheets to reduce core temperature has received little investigation, despite the practice and recommendation for its use in some military settings. Thus, the purpose of this study was to investigate the cooling efficacy of ice-sheet cooling (ISC) following exertional hyperthermia. METHODS: 13 (11 males, 2 females) participants (age = 23 ± 3 years, height = 176.5 ± 10.3 cm, mass = 78...
September 2017: Military Medicine
https://www.readbyqxmd.com/read/28880735/2017-midwest-zebrafish-meeting-report
#16
Elizabeth Sandquist, Sarah C Petersen, Cody J Smith
The 2017 Midwest Zebrafish meeting was held from June 16 to 18 at the University of Cincinnati, sponsored by the Cincinnati Children's Hospital Divisions of Developmental Biology, Molecular Cardiovascular Biology, and Gastroenterology, Hepatology, and Nutrition. The meeting, organized by Saulius Sumanas, Joshua Waxman, and Chunyue Yin, hosted >130 attendees from 16 different states. Scientific sessions were focused on morphogenesis, neural development, novel technologies, and disease models, with Steve Ekker, Stephen Potter, and Lila Solnica-Krezel presenting keynote talks...
September 7, 2017: Zebrafish
https://www.readbyqxmd.com/read/28880540/hydrocarbon-and-carbon-dioxide-fluxes-from-natural-gas-well-pad-soils-and-surrounding-soils-in-eastern-utah
#17
Seth N Lyman, Cody Watkins, Colleen Jones, Marc L Mansfield, Michael McKinley, Donna Kenney, Jordan Evans
We measured fluxes of methane, non-methane hydrocarbons, and carbon dioxide from natural gas well pad soils and from nearby undisturbed soils in eastern Utah. Methane fluxes varied from less than zero to more than 38 g m-2 h-1. Fluxes from well pad soils were almost always greater than from undisturbed soils. Fluxes were greater from locations with higher concentrations of total combustible gas in soil and were inversely correlated with distance from well heads. Several lines of evidence show that the majority of emission fluxes (about 70%) were primarily due to subsurface sources of raw gas that migrated to the atmosphere, with the remainder likely caused primarily by re-emission of spilled liquid hydrocarbons...
September 7, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28879682/criminal-thinking-shifts-among-male-prisoners-participating-in-a-cognitive-based-education-programme
#18
Cody Warner, Timothy Conley, Riley Murphy
BACKGROUND: Many prisoners rationalise criminal behaviour, and this type of thinking has been linked to recidivism. Correctional programmes for modifying criminal thinking can reshape how offenders view themselves and their circumstances. AIM: Our aim was to test whether participation in a cognitive-based curriculum called Steps to Economic and Personal Success (STEPS) was associated with changes in criminal thinking. METHODS: The STEPS curriculum is delivered in 15 video-based facilitated classes...
September 6, 2017: Criminal Behaviour and Mental Health: CBMH
https://www.readbyqxmd.com/read/28879201/wnt-%C3%AE-catenin-pathway-and-epigenetic-mechanisms-regulate-the-pitt-hopkins-syndrome-and-schizophrenia-risk-gene-tcf4
#19
Krista M Hennig, Daniel M Fass, Wen-Ning Zhao, Steven D Sheridan, Ting Fu, Serkan Erdin, Alexei Stortchevoi, Diane Lucente, Jannine D Cody, David Sweetser, James F Gusella, Michael E Talkowski, Stephen J Haggarty
Genetic variation within the transcription factor TCF4 locus can cause the intellectual disability and developmental disorder Pitt-Hopkins syndrome (PTHS), whereas single-nucleotide polymorphisms within noncoding regions are associated with schizophrenia. These genetic findings position TCF4 as a link between transcription and cognition; however, the neurobiology of TCF4 remains poorly understood. Here, we quantitated multiple distinct TCF4 transcript levels in human induced pluripotent stem cell-derived neural progenitors and differentiated neurons, and PTHS patient fibroblasts...
July 2017: Molecular Neuropsychiatry
https://www.readbyqxmd.com/read/28879002/polarized-light-use-in-the-nocturnal-bull-ant-myrmecia-midas
#20
Cody A Freas, Ajay Narendra, Corentin Lemesle, Ken Cheng
Solitary foraging ants have a navigational toolkit, which includes the use of both terrestrial and celestial visual cues, allowing individuals to successfully pilot between food sources and their nest. One such celestial cue is the polarization pattern in the overhead sky. Here, we explore the use of polarized light during outbound and inbound journeys and with different home vectors in the nocturnal bull ant, Myrmecia midas. We tested foragers on both portions of the foraging trip by rotating the overhead polarization pattern by ±45°...
August 2017: Royal Society Open Science
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