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https://www.readbyqxmd.com/read/28217486/skindia-quiz-33-solitary-pigmented-plaque-containing-a-blue-gray-papule
#1
Cody J Connor, Brian L Swick
No abstract text is available yet for this article.
January 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/28213060/prediction-of-cesarean-delivery-in-the-term-nulliparous-woman-results-from-the-prospective-multi-center-genesis-study
#2
Naomi Burke, Gerard Burke, Fionnuala Breathnach, Fionnuala Mcauliffe, John J Morrison, Michael Turner, Samina Dornan, John R Higgins, Amanda Cotter, Michael Geary, Peter Mcparland, Sean Daly, Fiona Cody, Pat Dicker, Elizabeth Tully, Fergal D Malone
BACKGROUND: In contemporary practice many nulliparous women require intervention during childbirth such as operative vaginal delivery or Cesarean delivery (CD). Despite the knowledge that the rising CD rate is associated with increasing maternal age, obesity and larger infant birthweight, we lack a reliable method to predict the requirement for such potentially hazardous obstetric procedures during labor and delivery. This issue is important as there are higher rates of morbidity and mortality associated with unplanned CD performed in labor compared to scheduled Cesarean deliveries...
February 14, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28207573/genome-wide-analysis-of-clopidogrel-active-metabolite-levels-identifies-novel-variants-that-influence-antiplatelet-response
#3
Joshua D Backman, Jeffrey R O'Connell, Keith Tanner, Cody J Peer, William D Figg, Shawn D Spencer, Braxton D Mitchell, Alan R Shuldiner, Laura M Yerges-Armstrong, Richard B Horenstein, Joshua P Lewis
Clopidogrel is one of the most commonly used therapeutics for the secondary prevention of cardiovascular events in patients with acute coronary syndromes. However, considerable interindividual variation in clopidogrel response has been documented, resulting in suboptimal therapy and an increased risk of recurrent events for some patients. In this investigation, we carried out the first genome-wide association study of circulating clopidogrel active metabolite levels in 513 healthy participants to directly measure clopidogrel pharmacokinetics...
February 15, 2017: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/28202961/early-brain-development-in-infants-at-high-risk-for-autism-spectrum-disorder
#4
Heather Cody Hazlett, Hongbin Gu, Brent C Munsell, Sun Hyung Kim, Martin Styner, Jason J Wolff, Jed T Elison, Meghan R Swanson, Hongtu Zhu, Kelly N Botteron, D Louis Collins, John N Constantino, Stephen R Dager, Annette M Estes, Alan C Evans, Vladimir S Fonov, Guido Gerig, Penelope Kostopoulos, Robert C McKinstry, Juhi Pandey, Sarah Paterson, John R Pruett, Robert T Schultz, Dennis W Shaw, Lonnie Zwaigenbaum, Joseph Piven
Brain enlargement has been observed in children with autism spectrum disorder (ASD), but the timing of this phenomenon, and the relationship between ASD and the appearance of behavioural symptoms, are unknown. Retrospective head circumference and longitudinal brain volume studies of two-year olds followed up at four years of age have provided evidence that increased brain volume may emerge early in development. Studies of infants at high familial risk of autism can provide insight into the early development of autism and have shown that characteristic social deficits in ASD emerge during the latter part of the first and in the second year of life...
February 15, 2017: Nature
https://www.readbyqxmd.com/read/28196438/patient-factors-associated-with-higher-expectations-from-foot-and-ankle-surgery
#5
Elizabeth A Cody, Carol A Mancuso, Jayme C Burket, Anca Marinescu, Aoife MacMahon, Scott J Ellis
BACKGROUND: Few authors have investigated patients' expectations from foot and ankle surgery. In this study, we aimed to examine relationships between patients' preoperative expectations and their demographic and clinical characteristics. We hypothesized that patients with more disability and those with anxiety or depressive symptoms would have greater expectations. METHODS: All adult patients scheduled for elective foot or ankle surgery by 1 of 6 orthopaedic foot and ankle surgeons were screened for inclusion over 8 months...
February 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28186341/embracing-discordance-phylogenomic-analyses-provide-evidence-for-allopolyploidy-leading-to-cryptic-diversity-in-a-mediterranean-campanula-campanulaceae-clade
#6
Andrew A Crowl, Cody Myers, Nico Cellinese
The Mediterranean Basin harbors a remarkable amount of biodiversity, a high proportion of which is endemic to this region. Here we present an in-depth study of an angiosperm species complex, in which cryptic taxonomic diversity has been hypothesized. Specifically, we focus on four currently recognized species in the Roucela complex, a well-supported clade in the Campanulaceae/Campanuloideae: Campanula creutzburgii, C. drabifolia, C. erinus, and C. simulans. This study takes a phylogenomic approach, utilizing near-complete plastomes and 130 nuclear loci, to uncover cryptic diversity and test hypotheses regarding hybridization and polyploidy within this clade...
February 10, 2017: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/28183865/compass-cues-used-by-a-nocturnal-bull-ant-myrmecia-midas
#7
Cody A Freas, Ajay Narendra, Ken Cheng
Ants use both terrestrial landmarks and cues derived from path integration to navigate to and from their nest location. These cues persist even as light levels drop during the twilight/night. Here we determined the compass cues used by a nocturnal bull ant, Myrmecia midas, in which the majority of the individuals begin foraging during the evening twilight period. Foragers of M. midas with vectors of≤5 m when displaced to unfamiliar locations did not follow the home vector, but instead showed random heading directions...
February 9, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28183511/proposed-standardized-neurological-endpoints-for-cardiovascular-clinical-trials-an-academic-research-consortium-initiative
#8
REVIEW
Alexandra J Lansky, Steven R Messé, Adam M Brickman, Michael Dwyer, H Bart van der Worp, Ronald M Lazar, Cody G Pietras, Kevin J Abrams, Eugene McFadden, Nils H Petersen, Jeffrey Browndyke, Bernard Prendergast, Vivian G Ng, Donald E Cutlip, Samir Kapadia, Mitchell W Krucoff, Axel Linke, Claudia Scala Moy, Joachim Schofer, Gerrit-Anne van Es, Renu Virmani, Jeffrey Popma, Michael K Parides, Susheel Kodali, Michel Bilello, Robert Zivadinov, Joseph Akar, Karen L Furie, Daryl Gress, Szilard Voros, Jeffrey Moses, David Greer, John K Forrest, David Holmes, Arie P Kappetein, Michael Mack, Andreas Baumbach
Surgical and catheter-based cardiovascular procedures and adjunctive pharmacology have an inherent risk of neurological complications. The current diversity of neurological endpoint definitions and ascertainment methods in clinical trials has led to uncertainties in the neurological risk attributable to cardiovascular procedures and inconsistent evaluation of therapies intended to prevent or mitigate neurological injury. Benefit-risk assessment of such procedures should be on the basis of an evaluation of well-defined neurological outcomes that are ascertained with consistent methods and capture the full spectrum of neurovascular injury and its clinical effect...
February 14, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28182454/mother-adolescent-conflict-types-and-adolescent-adjustment-a-person-oriented-analysis
#9
Melissa Huey, Cody Hiatt, Brett Laursen, William J Burk, Kenneth Rubin
This investigation was designed to identify dyadic differences in mother-adolescent conflict. In 2 studies (N = 131 and N = 147), adolescents (M = 13.88 and 14.65 years old) described the number of disagreements with mothers during the previous (1 or 3) days, their affective intensity, and perceptions of negativity in the relationship. Cluster analyses yielded 3 unique groups that replicated across studies: (a) placid dyads (50% of Study 1 participants and 36% of Study 2 participants), notable for low disagreement affective intensity and low relationship negativity; (b) explosive dyads (25% of Study 1 participants and 31% of Study 2 participants), notable for high affective intensity; and (c) squabbling dyads (25% of Study 1 participants and 33% of Study 2 participants), notable for frequent conflict...
February 9, 2017: Journal of Family Psychology: JFP
https://www.readbyqxmd.com/read/28181993/bariatric-surgery-prior-to-index-screening-colonoscopy-is-associated-with-a-decreased-rate-of-colorectal-adenomas-in-obese-individuals
#10
Dmitriy Kedrin, Shaan-Chirag Chandrahas Gandhi, Molly Wolf, Jatin Roper, Omer Yilmaz, Kathleen Corey, Hamed Khalili, Fatima Cody Stanford, Manish Gala
OBJECTIVES: Obesity is an important risk factor for the development of colorectal cancer (CRC). Although the impact of bariatric surgery on CRC is conflicting, its impact on precursor lesions is unknown. The aim of this study was to determine whether bariatric surgery before index screening colonoscopy is associated with decreased development of colorectal adenomas. METHODS: We performed a retrospective cohort study of bariatric surgery patients who had undergone index, screening colonoscopy at an academic center from 2001 to 2014...
February 9, 2017: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/28177892/pevonedistat-a-nedd8-activating-enzyme-inhibitor-sensitizes-neoplastic-b-cells-to-death-receptor-mediated-apoptosis
#11
Cody Paiva, J Claire Godbersen, Taylor Rowland, Olga V Danilova, Christopher Danes, Allison Berger, Alexey V Danilov
While death receptor ligands (Fas and TRAIL) kill chemoresistant tumor cell lines, related therapies have limited clinical efficacy as single agents. Death receptor signaling is modulated by nuclear factor-κB (NFκB), a family of transcription factors which are constitutively active in B-cell malignancies. We and others have shown that pevonedistat, an investigational inhibitor of the NEDD8-activating enzyme, abrogates NFκB activity in B-cell neoplasia. Here we demonstrate that diffuse large B-cell lymphoma, particularly activated B-cell type, and primary chronic lymphocytic leukemia cells are re-sensitized to extrinsic apoptosis by pevonedistat...
February 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28175457/326%C3%A2-cerebral-contusions-catalysts-and-counteractants
#12
Joseph Carnevale, David J Segar, Benjamin Drapcho, Cody Doberstein, John F Morrison, Wael Asaad
No abstract text is available yet for this article.
August 1, 2016: Neurosurgery
https://www.readbyqxmd.com/read/28171522/proposed-standardized-neurological-endpoints-for-cardiovascular-clinical-trials
#13
Alexandra J Lansky, Steven R Messé, Adam M Brickman, Michael Dwyer, H Bart van der Worp, Ronald M Lazar, Cody G Pietras, Kevin J Abrams, Eugene McFadden, Nils H Petersen, Jeffrey Browndyke, Bernard Prendergast, Vivian G Ng, Donald E Cutlip, Samir Kapadia, Mitchell W Krucoff, Axel Linke, Claudia Scala Moy, Joachim Schofer, Gerrit-Anne van Es, Renu Virmani, Jeffrey Popma, Michael K Parides, Susheel Kodali, Michel Bilello, Robert Zivadinov, Joseph Akar, Karen L Furie, Daryl Gress, Szilard Voros, Jeffrey Moses, David Greer, John K Forrest, David Holmes, Arie P Kappetein, Michael Mack, Andreas Baumbach
No abstract text is available yet for this article.
February 7, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28167931/the-active-component-of-aspirin-salicylic-acid-promotes-staphylococcus-aureus-biofilm-formation-in-a-pia-dependent-manner
#14
Cristian Dotto, Andrea Lombarte Serrat, Natalia Cattelan, María S Barbagelata, Osvaldo M Yantorno, Daniel O Sordelli, Monika Ehling-Schulz, Tom Grunert, Fernanda R Buzzola
Aspirin has provided clear benefits to human health. But salicylic acid (SAL) -the main aspirin biometabolite- exerts several effects on eukaryote and prokaryote cells. SAL can affect, for instance, the expression of Staphylococcus aureus virulence factors. SAL can also form complexes with iron cations and it has been shown that different iron chelating molecules diminished the formation of S. aureus biofilm. The aim of this study was to elucidate whether the iron content limitation caused by SAL can modify the S...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28167344/unexpected-widespread-hypophosphatemia-and-bone-disease-associated-with-elemental-formula-use-in-infants-and-children
#15
Luisa F Gonzalez Ballesteros, Nina S Ma, Rebecca J Gordon, Leanne Ward, Philippe Backeljauw, Halley Wasserman, David R Weber, Linda A DiMeglio, Julie Gagne, Robert Stein, Declan Cody, Kimber Simmons, Paul Zimakas, Lisa Swartz Topor, Sungeeta Agrawal, Andrew Calabria, Peter Tebben, Ruth Faircloth, Erik A Imel, Linda Casey, Thomas O Carpenter
OBJECTIVE: Hypophosphatemia occurs with inadequate dietary intake, malabsorption, increased renal excretion, or shifts between intracellular and extracellular compartments. We noticed the common finding of amino-acid based elemental formula [EF] use in an unexpected number of cases of idiopathic hypophosphatemia occurring in infants and children evaluated for skeletal disease. We aimed to fully characterize the clinical profiles in these cases. METHODS: A retrospective chart review of children with unexplained hypophosphatemia was performed as cases accumulated from various centres in North America and Ireland...
February 4, 2017: Bone
https://www.readbyqxmd.com/read/28166818/resistant-starch-can-improve-insulin-sensitivity-independently-of-the-gut-microbiota
#16
Laure B Bindels, Rafael R Segura Munoz, João Carlos Gomes-Neto, Valentin Mutemberezi, Inés Martínez, Nuria Salazar, Elizabeth A Cody, Maria I Quintero-Villegas, Hatem Kittana, Clara G de Los Reyes-Gavilán, Robert J Schmaltz, Giulio G Muccioli, Jens Walter, Amanda E Ramer-Tait
BACKGROUND: Obesity-related diseases, including type 2 diabetes and cardiovascular disease, have reached epidemic proportions in industrialized nations, and dietary interventions for their prevention are therefore important. Resistant starches (RS) improve insulin sensitivity in clinical trials, but the mechanisms underlying this health benefit remain poorly understood. Because RS fermentation by the gut microbiota results in the formation of physiologically active metabolites, we chose to specifically determine the role of the gut microbiota in mediating the metabolic benefits of RS...
February 7, 2017: Microbiome
https://www.readbyqxmd.com/read/28166468/dose-finding-designs-for-trials-of-molecularly-targeted-agents-and-immunotherapies
#17
Cody Chiuzan, Jonathan Shtaynberger, Gulam A Manji, Jimmy K Duong, Gary K Schwartz, Anastasia Ivanova, Shing M Lee
Recently, there has been a surge of early phase trials of molecularly targeted agents (MTAs) and immunotherapies. These new therapies have different toxicity profiles compared to cytotoxic therapies. MTAs can benefit from new trial designs that allow inclusion of low-grade toxicities, late-onset toxicities, addition of an efficacy endpoint, and flexibility in the specification of a target toxicity probability. To study the degree of adoption of these methods, we conducted a Web of Science search of articles published between 2008 and 2014 that describe phase 1 oncology trials...
February 6, 2017: Journal of Biopharmaceutical Statistics
https://www.readbyqxmd.com/read/28166257/size-matters-predator-outbreaks-threaten-foundation-species-in-small-marine-protected-areas
#18
Cody S Clements, Mark E Hay
The unanticipated impacts of consumers in fragmented habitats are frequently a challenge for ecosystem management. On Indo-Pacific coral reefs, crown-of-thorns sea stars (Acanthaster spp.) are coral predators whose outbreaks cause precipitous coral decline. Across large spatial scales, Acanthaster densities are lower in large no-take Marine Protected Areas (MPAs) and reefs subject to limited human exploitation. However, using a combination of observational and manipulative experiments, we found that Acanthaster densities within a network of small, no-take MPAs on reef flats in Fiji were ~2-3...
2017: PloS One
https://www.readbyqxmd.com/read/28159103/improved-modeling-of-multivariate-measurement-errors-based-on-the-wishart-distribution
#19
Peter D Wentzell, Cody S Cleary, M Kompany-Zareh
The error covariance matrix (ECM) is an important tool for characterizing the errors from multivariate measurements, representing both the variance and covariance in the errors across multiple channels. Such information is useful in understanding and minimizing sources of experimental error and in the selection of optimal data analysis procedures. Experimental ECMs, normally obtained through replication, are inherently noisy, inconvenient to obtain, and offer limited interpretability. Significant advantages can be realized by building a model for the ECM based on established error types...
March 22, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28158183/beyond-the-mhc-a-canine-model-of-dermatomyositis-shows-a-complex-pattern-of-genetic-risk-involving-novel-loci
#20
Jacquelyn M Evans, Rooksana E Noorai, Kate L Tsai, Alison N Starr-Moss, Cody M Hill, Kendall J Anderson, Thomas R Famula, Leigh Anne Clark
Juvenile dermatomyositis (JDM) is a chronic inflammatory myopathy and vasculopathy driven by genetic and environmental influences. Here, we investigated the genetic underpinnings of an analogous, spontaneous disease of dogs also termed dermatomyositis (DMS). As in JDM, we observed a significant association with a haplotype of the major histocompatibility complex (MHC) (DLA-DRB1*002:01/-DQA1*009:01/-DQB1*001:01), particularly in homozygosity (P-val = 0.0001). However, the high incidence of the haplotype among healthy dogs indicated that additional genetic risk factors are likely involved in disease progression...
February 2017: PLoS Genetics
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