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https://www.readbyqxmd.com/read/29332604/the-effect-of-an-adenosine-a2a-agonist-on-intra-tumoral-concentrations-of-temozolomide-in-patients-with-recurrent-glioblastoma
#1
Sadhana Jackson, Jon Weingart, Edjah K Nduom, Thura T Harfi, Richard T George, Dorothea McAreavey, Xiaobu Ye, Nicole M Anders, Cody Peer, William D Figg, Mark Gilbert, Michelle A Rudek, Stuart A Grossman
BACKGROUND: The blood-brain barrier (BBB) severely limits the entry of systemically administered drugs including chemotherapy to the brain. In rodents, regadenoson activation of adenosine A2A receptors causes transient BBB disruption and increased drug concentrations in normal brain. This study was conducted to evaluate if activation of A2A receptors would increase intra-tumoral temozolomide concentrations in patients with glioblastoma. METHODS: Patients scheduled for a clinically indicated surgery for recurrent glioblastoma were eligible...
January 15, 2018: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/29332521/a-template-analysis-of-intimate-partner-violence-survivors-experiences-of-animal-maltreatment-implications-for-safety-planning-and-intervention
#2
Elizabeth A Collins, Anna M Cody, Shelby Elaine McDonald, Nicole Nicotera, Frank R Ascione, James Herbert Williams
This study explores the intersection of intimate partner violence (IPV) and animal cruelty in an ethnically diverse sample of 103 pet-owning IPV survivors recruited from community-based domestic violence programs. Template analysis revealed five themes: (a) Animal Maltreatment by Partner as a Tactic of Coercive Power and Control, (b) Animal Maltreatment by Partner as Discipline or Punishment of Pet, (c) Animal Maltreatment by Children, (d) Emotional and Psychological Impact of Animal Maltreatment Exposure, and (e) Pets as an Obstacle to Effective Safety Planning...
March 1, 2017: Violence Against Women
https://www.readbyqxmd.com/read/29330259/limited-accuracy-of-administrative-data-for-the-identification-and-classification-of-adult-congenital-heart-disease
#3
Abigail Khan, Katrina Ramsey, Cody Ballard, Emily Armstrong, Luke J Burchill, Victor Menashe, George Pantely, Craig S Broberg
BACKGROUND: Administrative data sets utilize billing codes for research and quality assessment. Previous data suggest that such codes can accurately identify adults with congenital heart disease (CHD) in the cardiology clinic, but their use has yet to be validated in a larger population. METHODS AND RESULTS: All administrative codes from an entire health system were queried for a single year. Adults with a CHD diagnosis code (International Classification of Diseases, Ninth Revision, (ICD-9) codes 745-747) defined the cohort...
January 12, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29328087/theoretical-modeling-and-design-of-photonic-structures-in-zeolite-nanocomposites-for-gas-sensing-part-ii-volume-gratings
#4
D Cody, I Naydenova
The suitability of holographic structures fabricated in zeolite nanoparticle-polymer composite materials for gas sensing applications has been investigated. Theoretical modeling of the sensor response (i.e., change in hologram readout due to a change in refractive index modulation or thickness as a result of gas adsorption) of different sensor designs was carried out using the Raman-Nath theory and Kogelnik's coupled wave theory. The influence of a range of parameters on the sensitivity of holographically recorded surface and volume photonic structures has been studied, namely, hologram geometry, hologram thickness and spatial frequency, reconstruction wavelength, and zeolite nanoparticle refractive index...
January 1, 2018: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/29327941/infection-is-not-required-for-mucoinflammatory-lung-disease-in-cftr-knockout-ferrets
#5
Bradley H Rosen, T Idil Apak Evans, Shashanna R Moll, Jaimie S Gray, Bo Liang, Xingshen Sun, Yulong Zhang, Chandler W Jensen-Cody, Anthony M Swatek, Weihong Zhou, Nan He, Pavana G Rotti, Scott R Tyler, Nicholas W Keiser, Preston J Anderson, Leonard Brooks, Yalan Li, R Marshall Pope, Maheen Rajput, Eric A Hoffman, Kai Wang, J Kirk Harris, Kalpaj R Parekh, Katherine N Gibson-Corley, John F Engelhardt
RATIONALE: Classical interpretation of cystic fibrosis (CF) lung disease pathogenesis suggests that infection initiates disease progression, leading to an exuberant inflammatory response, excessive mucus, and ultimately bronchiectasis. While symptomatic antibiotic treatment controls lung infections early in disease, life-long bacterial residence typically ensues. Processes that control the establishment of persistent bacteria in the CF lung, and the contribution of non-infectious components to disease pathogenesis, are poorly understood...
January 12, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29324306/mechanically-resilient-injectable-scaffolds-for-intramuscular-stem-cell-delivery-and-cytokine-release
#6
Stuart A Young, Stephen E Sherman, Tyler T Cooper, Cody Brown, Fraz Anjum, David A Hess, Lauren E Flynn, Brian G Amsden
A promising strategy for treating peripheral ischemia involves the delivery of stem cells to promote angiogenesis through paracrine signaling. Treatment success depends on cell localization, retention, and survival within the mechanically dynamic intramuscular (IM) environment. Herein we describe an injectable, in situ-gelling hydrogel for the IM delivery of adipose-derived stem/stromal cells (ASCs), specifically designed to withstand the dynamic loading conditions of the lower limb and facilitate cytokine release from encapsulated cells...
January 4, 2018: Biomaterials
https://www.readbyqxmd.com/read/29322555/evaluating-factors-impacting-medication-adherence-among-rural-urban-and-suburban-populations
#7
Cody Arbuckle, Daniel Tomaszewski, Benjamin D Aronson, Lawrence Brown, Jon Schommer, Donald Morisky, Erik Linstead
PURPOSE: To evaluate differences in prescription medication adherence rates, as well as influencing factors, in rural and urban adults. METHODS: This is a retrospective analysis of the 2015 National Consumer Survey on the Medication Experience and Pharmacists' Role. A total of 26,173 participants completed the survey and provided usable data. Participants using between 1 and 30 prescription medications and living more than 0 miles and up to 200 miles from their nearest pharmacy were selected for the study, resulting in a total of 15,933 participants...
January 10, 2018: Journal of Rural Health
https://www.readbyqxmd.com/read/29320474/high-response-rate-to-pd-1-blockade-in-desmoplastic-melanomas
#8
Zeynep Eroglu, Jesse M Zaretsky, Siwen Hu-Lieskovan, Dae Won Kim, Alain Algazi, Douglas B Johnson, Elizabeth Liniker, Ben Kong, Rodrigo Munhoz, Suthee Rapisuwon, Pier Federico Gherardini, Bartosz Chmielowski, Xiaoyan Wang, I Peter Shintaku, Cody Wei, Jeffrey A Sosman, Richard W Joseph, Michael A Postow, Matteo S Carlino, Wen-Jen Hwu, Richard A Scolyer, Jane Messina, Alistair J Cochran, Georgina V Long, Antoni Ribas
Desmoplastic melanoma is a rare subtype of melanoma characterized by dense fibrous stroma, resistance to chemotherapy and a lack of actionable driver mutations, and is highly associated with ultraviolet light-induced DNA damage. We analysed sixty patients with advanced desmoplastic melanoma who had been treated with antibodies to block programmed cell death 1 (PD-1) or PD-1 ligand (PD-L1). Objective tumour responses were observed in forty-two of the sixty patients (70%; 95% confidence interval 57-81%), including nineteen patients (32%) with a complete response...
January 10, 2018: Nature
https://www.readbyqxmd.com/read/29317618/development-of-an-oral-once-weekly-drug-delivery-system-for-hiv-antiretroviral-therapy
#9
Ameya R Kirtane, Omar Abouzid, Daniel Minahan, Taylor Bensel, Alison L Hill, Christian Selinger, Anna Bershteyn, Morgan Craig, Shirley S Mo, Hormoz Mazdiyasni, Cody Cleveland, Jaimie Rogner, Young-Ah Lucy Lee, Lucas Booth, Farhad Javid, Sarah J Wu, Tyler Grant, Andrew M Bellinger, Boris Nikolic, Alison Hayward, Lowell Wood, Philip A Eckhoff, Martin A Nowak, Robert Langer, Giovanni Traverso
The efficacy of antiretroviral therapy is significantly compromised by medication non-adherence. Long-acting enteral systems that can ease the burden of daily adherence have not yet been developed. Here we describe an oral dosage form composed of distinct drug-polymer matrices which achieved week-long systemic drug levels of the antiretrovirals dolutegravir, rilpivirine and cabotegravir in a pig. Simulations of viral dynamics and patient adherence patterns indicate that such systems would significantly reduce therapeutic failures and epidemiological modelling suggests that using such an intervention prophylactically could avert hundreds of thousands of new HIV cases...
January 9, 2018: Nature Communications
https://www.readbyqxmd.com/read/29317045/evaluation-of-a-novel-thoracic-entry-device-versus-needle-decompression-in-a-tension-pneumothorax-swine-model
#10
John Kuckelman, Mike Derickson, Cody Phillips, Morgan Barron, Shannon Marko, Matthew Eckert, Matthew Martin
INTRODUCTION: Tension pneumothorax (tPTX) remains a major cause of preventable death in trauma. Needle decompression (ND) has up to a 60% failure rate. METHODS: Post-mortem swine used. Interventions were randomized to 14G-needle decompression (ND, n = 25), bladed trocar with 36Fr cannula (BTW, n = 16), bladed trocar alone (BTWO, n = 16) and surgical thoracostomy (ST = 11). Simulated tPTX was created to a pressure(p) of 20 mmHg. RESULTS: Success (p < 5 mmHg by 120 s) was seen in 41 of 68 (60%) interventions...
January 5, 2018: American Journal of Surgery
https://www.readbyqxmd.com/read/29316122/spectroscopic-characterization-of-a-c-f-c-fluoronium-ion-in-solution
#11
Cody Ross Pitts, Maxwell Gargiulo Holl, Thomas Lectka
We report the first spectroscopic evidence for a [C-F-C]+ fluoronium ion in solution. Extensive NMR studies (19F, 1H, 13C) characterize a symmetrical cage-like species in which fluorine exhibits substantial covalent bonding to each of the two carbon atoms involved in the three-center interaction. Experimental NMR data comport well with calculated values to lend credence to the structural assignment. As the culminating experiment, the Saunders isotopic perturbation test definitively confirms a symmetrical structure...
January 9, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29313238/proactive-interference-by-cues-presented-without-outcomes-differences-in-context-specificity-of-latent-inhibition-and-conditioned-inhibition
#12
Gonzalo Miguez, Bridget McConnell, Cody W Polack, Ralph R Miller
This report is part of a larger project examining associative interference as a function of the nature of the interfering and target associations. Lick suppression experiments with rats assessed the effects of context shifts on proactive outcome interference by latent inhibition (LI) and Pavlovian conditioned inhibition (CI) treatments on subsequently trained Pavlovian conditioned excitation treatment. LI and CI were trained in Context A during Phase 1, and then excitation treatment was administered in Context B during Phase 2, followed by tests for conditioned excitation in Contexts A, B, or C...
January 8, 2018: Learning & Behavior
https://www.readbyqxmd.com/read/29303582/spectroscopic-study-of-a-photoactive-antibacterial-agent-2-3-distyrylindole
#13
Ruwini Dinushika Rajapaksha, Matthias Banet, Cody Champion, Liliya V Frolova, Snezna Rogelj, Pabitra Choudhury, Mahinda Iroshana Ranasinghe
Optical properties and fluorescence decay dynamics of a photoactive indole based antibacterial chromophore system, 2, 3-distyrylindole (23DSI), was investigated using various spectroscopic characterization techniques. These studies were done by utilizing the steady state UV-Vis spectroscopy, the steady state fluorescence spectroscopy, the time-resolve fluorescence upconversion spectroscopy, and time correlated single photon counting spectroscopy as experiment techniques. Our studies show that the 23DSI molecule has a multiphoton absorbing property as indicated by two and three photon absorption in both solution and solid phases...
January 5, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29303442/blossoming-contusions-identifying-factors-contributing-to-the-expansion-of-traumatic-intracerebral-hemorrhage
#14
Joseph A Carnevale, David J Segar, Andrew Y Powers, Meghal Shah, Cody Doberstein, Benjamin Drapcho, John F Morrison, John R Williams, Scott Collins, Kristina Monteiro, Wael F Asaad
OBJECTIVE Traumatic brain injury (TBI) remains a significant cause of neurological morbidity and mortality. Each year, more than 1.7 million patients present to the emergency department with TBI. The goal of this study was to evaluate the prognosis of traumatic cerebral intraparenchymal hemorrhage (tIPH), to develop subclassifications of these injuries that relate to prognosis, and to provide a more comprehensive assessment of hemorrhagic progression contusion (HPC) by analyzing the rate at which tIPH "blossom" (i...
January 5, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29303241/fabrication-of-suspended-iii-v-nanofoils-by-inverse-metal-assisted-chemical-etching-of-in0-49ga0-51p-gaas-heteroepitaxial-films
#15
Thomas S Wilhelm, Cody W Soule, Mohadeseh A Baboli, Christopher J O'Connell, Parsian K Mohseni
Metal-assisted chemical etching (MacEtch) has been established as a low-cost, benchtop, and versatile method for large-scale fabrication of semiconductor nanostructures and has been heralded as an alternative to conventional top-down approaches such as reactive-ion etching. However, extension of this technique to ternary III-V compound semiconductor alloys and heteroepitaxial systems has remained relatively unexplored. Here, Au-assisted and inverse-progression MacEtch (I-MacEtch) of the heteroepitaxial In0...
January 5, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29302968/writing-wrinkles-on-polydimethylsiloxane-pdms-by-surface-oxidation-with-a-co2-laser-engraver
#16
Lin Qi, Cody Ruck, Griffin Spychalski, Brian King, Benxin Wu, Yi Zhao
Surface wrinkles formed by the buckling of a strained stiff layer attached to a soft elastomer foundation has been widely used in a variety of applications. Micropatterning of wrinkled topographies is, however, limited by process/system complexities. In this paper, we report an approach to write surface wrinkles with desired pattern geometries on polydimethylsiloxane (PDMS) elastomers using a commercial infrared laser engraver with the spot size of 127 μm. Wrinkled micropatterns with the wavelength from < 50 μm to > 300 μm were obtained in minutes without using special facilities or atmospheres...
January 5, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29296755/12-hetre-inhibits-platelet-reactivity-and-thrombosis-in-part-through-the-prostacyclin-receptor
#17
Benjamin E Tourdot, Reheman Adili, Zitha R Isingizwe, Meral Ebrahem, J Cody Freedman, Theodore R Holman, Michael Holinstat
The dihomo-γ-linolenic acid (DGLA)-derived metabolite of 12-lipoxygenase, 12-hydroxy-eicosatrienoic acid (12-HETrE), was recently shown to potently inhibit thrombus formation without prolonging bleeding in murine models. Although 12-HETrE was found to inhibit platelet activation via the Gαs signaling pathway, the Gαs-coupled receptor by which 12-HETrE mediates its antiplatelet effects has yet to be identified. Defining the receptor by which 12-HETrE exerts its effects is key to determining its therapeutic potential as an antiplatelet drug...
June 27, 2017: Blood Advances
https://www.readbyqxmd.com/read/29294719/biological-evidence-in-adult-and-adolescent-sexual-assault-cases-timing-and-relationship-to-arrest
#18
Theodore P Cross, Megan Alderden, Alex Wagner, Lisa Sampson, Brittany Peters, Kaitlin Lounsbury
This study examined the timing of the crime laboratory report relative to arrests in sexual assault cases and explored the relationship between biological evidence and arrest in those cases in which the crime laboratory report came first and thus could have influenced the arrest decision. A random sample ( N = 528) of cases that occurred between 2008 and 2010 and included a report to police was drawn from a Massachusetts statewide database of medical reports on sexual assault cases. Data from medical providers were merged with data abstracted from crime laboratory reports and with data requested from police departments...
April 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29290364/association-of-sarcopenic-obesity-predicted-by-anthropometric-measurements-and-24-y-all-cause-mortality-in-elderly-men-the-kuakini-honolulu-heart-program
#19
Kiyoshi Sanada, Randi Chen, Bradley Willcox, Tomoyuki Ohara, Aida Wen, Cody Takenaka, Kamal Masaki
OBJECTIVE: The aim of this study was to investigate the association between anthropometric measurements of sarcopenic obesity and all-cause mortality. METHODS: The study included 2309 Japanese-American men ages 71 to 93 y. Mortality data were available for up to 24 y of follow-up. Sarcopenic obesity defined by three patterns of obesity indexes (body mass index [BMI], percent body fat [%BF] and waist circumference [WC]) and skeletal muscle index estimated by anthropometric measurements...
February 2018: Nutrition
https://www.readbyqxmd.com/read/29288052/hydrophobic-interactions-of-sucralose-with-protein-structures
#20
Nimesh Shukla, Enrico Pomarico, Cody J S Hecht, Erika A Taylor, Majed Chergui, Christina M Othon
Sucralose is a commonly employed artificial sweetener that appears to destabilize protein native structures. This is in direct contrast to the bio-preservative nature of its natural counterpart, sucrose, which enhances the stability of biomolecules against environmental stress. We have further explored the molecular interactions of sucralose as compared to sucrose to illuminate the origin of the differences in their bio-preservative efficacy. We show that the mode of interactions of sucralose and sucrose in bulk solution differ subtly through the use of hydration dynamics measurement and computational simulation...
December 26, 2017: Archives of Biochemistry and Biophysics
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