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https://www.readbyqxmd.com/read/28644231/considerations-for-pa-education-and-training
#1
Cody A Sasek, Heather E Yates
No abstract text is available yet for this article.
July 2017: JAAPA: Official Journal of the American Academy of Physician Assistants
https://www.readbyqxmd.com/read/28639122/targeting-prostate-specific-membrane-antigen-psma-with-f-18-labeled-compounds-the-influence-of-prosthetic-groups-on-tumor-uptake-and-clearance-profile
#2
Vincent Bouvet, Melinda Wuest, Justin J Bailey, Cody Bergman, Nancy Janzen, John F Valliant, Frank Wuest
PURPOSE: Prostate-specific membrane antigen (PSMA) is an important biomarker expressed in the majority of prostate cancers. The favorable positron emission tomography (PET) imaging profile of the PSMA imaging agent 2-(3-(1-carboxy-5-[(6-[(18)F]fluoro-pyridine-3-carbonyl)-amino]-pentyl)-ureido)-pentane-dioic acid [(18)F]DCFPyL in preclinical prostate cancer models and in prostate cancer patients stimulated the development and validation of other fluorine-containing PSMA inhibitors to further enhance pharmacokinetics and simplify production methods...
June 21, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28638292/combined-oral-contraceptive-pill-initiation-in-a-patient-with-major-depressive-disorder-premenstrual-dysphoric-disorder-social-anxiety-panic-disorder-and-histrionic-personality-disorder
#3
Cody Roi, Erich J Conrad
BACKGROUND: Comorbid psychiatric conditions present an added layer of challenge in managing patients, as each condition and associated set of symptoms exacerbate the complexity of the overall presentation. Premenopausal women may be at particular risk for inadequate care, as their comorbid conditions may present overlapping symptoms and mask independent premenstrual symptoms. The prevalence of premenstrual dysphoric disorder and associated conditions can be as high as 8% in women of reproductive age...
2017: Ochsner Journal
https://www.readbyqxmd.com/read/28636746/evaluation-of-the-parent-report-inventory-of-callous-unemotional-traits-in-a-sample-of-children-recruited-from-intimate-partner-violence-services-a-multidimensional-rasch-analysis
#4
Shelby Elaine McDonald, Lin Ma, Kathy E Green, Stephanie A Hitti, Anna M Cody, Courtney Donovan, James Herbert Williams, Frank R Ascione
OBJECTIVE: Our study applied multidimensional item response theory (MIRT) to compare structural models of the parent-report version of the Inventory of Callous and Unemotional Traits (ICU; English and North American Spanish translations). METHOD: A total of 291 maternal caregivers were recruited from community-based domestic violence services and reported on their children (77.9% ethnic minority; 47% female), who ranged in age from 7 to 12 years (mean = 9.07, standard deviation = 1...
June 21, 2017: Journal of Clinical Psychology
https://www.readbyqxmd.com/read/28623356/high-risk-human-papillomavirus-e7-alters-host-dna-methylome-and-represses-hla-e-expression-in-human-keratinocytes
#5
Louis Cicchini, Rachel Z Blumhagen, Joseph A Westrich, Mallory E Myers, Cody J Warren, Charlotte Siska, David Raben, Katerina J Kechris, Dohun Pyeon
Human papillomavirus (HPV) infection distinctly alters methylation patterns in HPV-associated cancer. We have recently reported that HPV E7-dependent promoter hypermethylation leads to downregulation of the chemokine CXCL14 and suppression of antitumor immune responses. To investigate the extent of gene expression dysregulated by HPV E7-induced DNA methylation, we analyzed parallel global gene expression and DNA methylation using normal immortalized keratinocyte lines, NIKS, NIKS-16, NIKS-18, and NIKS-16∆E7...
June 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28622802/rapid-multiplex-dna-amplification-on-an-inexpensive-microdevice-for-human-identification-via-short-tandem-repeat-analysis
#6
Jacquelyn A DuVall, Delphine Le Roux, Brandon L Thompson, Christopher Birch, Daniel A Nelson, Jingyi Li, Daniel L Mills, An-Chi Tsuei, Martin G Ensenberger, Cindy Sprecher, Douglas R Storts, Brian E Root, James P Landers
Forensic DNA analysis requires several steps, including DNA extraction, PCR amplification, and separation of PCR fragments. Intuitively, there are numerous situations where it would be beneficial to speed up the overall DNA analysis process; in this work, we focus on the most time-consuming component in the analysis pipeline, namely the polymerase chain reaction (PCR). Primers were specially designed to target 10 human genomic loci, all yielding amplicons shorter than 350 bases, for ease of downstream integration with on-board microchip electrophoresis...
August 8, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28612073/cis-decalin-oxidation-as-a-stereochemical-probe-of-in-mof-versus-on-mof-catalysis
#7
Ashley D Cardenal, Hye Jeong Park, Cody J Chalker, Kacey G Ortiz, David C Powers
Development of catalyst-controlled C-H hydroxylation could provide direct access to valuable synthetic targets, such as primary metabolites. Here, we report a new family of porous materials, comprised of 2-dimensional metalloporphyrin layers and flexible aliphatic linkers, and demonstrate C-H hydroxylation activity. We demonstrate that the stereochemistry of cis-decalin oxidation provides a useful tool for differentiating catalysis in from catalysis on porous materials, which is critical to leveraging the potential of porous materials for catalyst-controlled oxidation chemistry...
June 14, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28611287/vorinostat-suppresses-hypoxia-signaling-by-modulating-nuclear-translocation-of-hypoxia-inducible-factor-1-alpha
#8
Chao Zhang, Chunzhang Yang, Michael J Feldman, Herui Wang, Ying Pang, Dominic M Maggio, Dongwang Zhu, Cody L Nesvick, Pauline Dmitriev, Petra Bullova, Prashant Chittiboina, Roscoe O Brady, Karel Pacak, Zhengping Zhuang
Histone deacetylase inhibitors (HDACis) are a potent class of tumor-suppressive agents traditionally believed to exert their effects through loosening tightly-wound chromatin resulting in de-inhibition of various tumor suppressive genes. Recent literature however has shown altered intratumoral hypoxia signaling with HDACi administration not attributable to changes in chromatin structure. We sought to determine the precise mechanism of HDACi-mediated hypoxia signaling attenuation using vorinostat (SAHA), an FDA-approved class I/IIb/IV HDACi...
May 23, 2017: Oncotarget
https://www.readbyqxmd.com/read/28609758/a-selection-guide-for-the-new-generation-6-dye-dna-profiling-systems
#9
Sze-Wah Lin, Christina Li, Stephen C Y Ip
The Federal Bureau of Investigation (FBI) has recently expanded the CODIS core loci from the existing 13 to 20 as a new guideline, and laboratories from the US are required to comply with the new regulation before uploading or conducting identity search in the national database. The expanded CODIS format, which shares all the core loci commonly used in the European countries and the US, not only increases international compatibility, but also reduces the number of adventitious matches, and hence facilitates international law enforcement and counterterrorism endeavours...
June 3, 2017: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/28608652/impact-of-pharmacy-services-on-cystic-fibrosis-medication-adherence
#10
Jeffery T Zobell, Elizabeth Schwab, Dave S Collingridge, Cody Ball, Robert Nohavec, Fadi Asfour
OBJECTIVES: The purpose of this study is to characterize the impact of pharmacy services on medication adherence and hospitalizations for pediatric cystic fibrosis (CF) patients. METHODS: A retrospective health insurance claims analysis and patient medical charts review from January 1, 2014 to December 31, 2016 of patients from the Pediatric Intermountain CF Center was performed. Adherence to dornase alfa and hospital admissions for pulmonary exacerbations pre and post the implementation of an integrated pharmacy team were reviewed...
June 13, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28608038/patient-values-and-preferences-surrounding-proton-pump-inhibitor-use-a-scoping-review
#11
REVIEW
Wade Thompson, Cody Black, Vivian Welch, Barbara Farrell, Lise M Bjerre, Peter Tugwell
BACKGROUND: Proton pump inhibitors (PPIs) treat various upper gastrointestinal (GI) diseases. Around 50% of patients may remain on PPIs long-term without ongoing need. Eligible patients should be offered the choice of continuing their PPI or trying to reduce/stop their PPI (deprescribing), a choice dependent on values and preferences. OBJECTIVES: Our objective was to systematically scope the available evidence on patient values and preferences surrounding continued PPI treatment and/or the decision to try a reduction in their PPI...
June 12, 2017: Patient
https://www.readbyqxmd.com/read/28605224/effect-of-a-cooling-kit-on-physiology-and-performance-following-exercise-in-the-heat
#12
Cody R Smith, Cory L Butts, J D Adams, Matthew A Tucker, Nicole E Moyen, Matthew S Ganio, Brendon P McDermott
CONTEXT: Exercising in the heat leads to an increase in body temperature that can increase the risk of heat illness or cause detriments in exercise performance. OBJECTIVE: To examine a phase change heat emergency kit (HEK) on thermoregulatory and perceptual responses, and subsequent exercise performance following exercise in the heat. DESIGN: Two randomized crossover trials which consisted of 30 minutes of exercise, 15 minutes of treatment (T1), performance testing (5-10-5 pro-agility test, 1500 m run), and another 15 minutes of treatment (T2) identical to T1...
June 12, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/28601894/lichenysin-production-is-improved-in-cody-null-bacillus-licheniformis-by-addition-of-precursor-amino-acids
#13
Chengjun Zhu, Fang Xiao, Yimin Qiu, Qin Wang, Zhili He, Shouwen Chen
Lichenysin is categorized into the family of lipopeptide biosurfactants and has a variety of applications in the petroleum industry, bioremediation, pharmaceuticals, and the food industry. Currently, large-scale production is limited due to the low yield. This study found that lichenysin production was repressed by supplementation of extracellular amino acids. The global transcriptional factor CodY was hypothesized to prevent lichenysin biosynthesis under an amino acid-rich condition in Bacillus licheniformis...
June 11, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28600982/altered-bioenergetics-and-enhanced-resistance-to-oxidative-stress-in-human-retinal-pigment-epithelial-cells-from-donors-with-age-related-macular-degeneration
#14
Deborah A Ferrington, Mara C Ebeling, Rebecca J Kapphahn, Marcia R Terluk, Cody R Fisher, Jorge R Polanco, Heidi Roehrich, Michaela M Leary, Zhaohui Geng, James R Dutton, Sandra R Montezuma
Age-related macular degeneration (AMD) is the leading cause of blindness among older adults. It has been suggested that mitochondrial defects in the retinal pigment epithelium (RPE) underlies AMD pathology. To test this idea, we developed primary cultures of RPE to ask whether RPE from donors with AMD differ in their metabolic profile compared with healthy age-matched donors. Analysis of gene expression, protein content, and RPE function showed that these cultured cells replicated many of the cardinal features of RPE in vivo...
June 1, 2017: Redox Biology
https://www.readbyqxmd.com/read/28600257/search-for-more-effective-microsatellite-markers-for-forensics-with-next-generation-sequencing
#15
Bowen Tan, Zicheng Zhao, Zhe Zhang, Shengbin Li, Shuai Cheng Li
Published by the Combined DNA Index System (CODIS) program of the Federal Bureau of Investigation (FBI) in 1997, the 13 core short tandem repeat (STR) loci are widely adopted as genetic markers in forensic applications, e.g., identity testing and paternity testing. However, these loci may be biased and suffer from reduced sensitivities towards specific population groups. In addition, the rapid growth of entries in forensic databases raises the chance of random hits, which can cause false recognitions of criminal suspects...
June 7, 2017: IEEE Transactions on Nanobioscience
https://www.readbyqxmd.com/read/28596944/cody-regulates-thiol-peroxidase-expression-as-part-of-the-pneumococcal-defense-mechanism-against-h2o2-stress
#16
Barak Hajaj, Hasan Yesilkaya, Sulman Shafeeq, Xiangyun Zhi, Rachel Benisty, Shiran Tchalah, Oscar P Kuipers, Nurith Porat
Streptococcus pneumoniae is a facultative anaerobic pathogen. Although it maintains fermentative metabolism, during aerobic growth pneumococci produce high levels of H2O2, which can have adverse effects on cell viability and DNA, and influence pneumococcal interaction with its host. The pneumococcus is unusual in its dealing with toxic reactive oxygen species (ROS) in that it neither has catalase nor the global regulators of peroxide stress resistance. Previously, we identified pneumococcal thiol peroxidase (TpxD) as the key enzyme for enzymatic removal of H2O2, and showed that TpxD synthesis is up-regulated upon exposure to H2O2...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28595934/secular-trends-in-prostate-biopsy-criteria-and-outcomes-the-dartmouth-experience
#17
Lael Reinstatler, Cody Rissman, John D Seigne, Elias S Hyams
OBJECTIVE: To evaluate trends in prostate biopsy and prostate cancer diagnosis at a center with conservative baseline screening practices in the pre- and post-2012 era. More restrictive prostate-specific antigen (PSA) screening guidelines have led to lower rates of screening, biopsy and diagnosis of prostate cancer post-2012. It is not clear, however, how regions with low baseline screening rates (e.g. the Lebanon, NH hospital referral region centered on Dartmouth-Hitchcock Medical Center, with the lowest rate of screening among Medicare patients in 2012) have responded these guidelines...
June 5, 2017: Urology
https://www.readbyqxmd.com/read/28595730/recurrent-large-genomic-rearrangements-in-brca1-and-brca2-in-an-irish-case-series
#18
Terri P McVeigh, Nuala Cody, Cliona Carroll, Marie Duff, Michael Farrell, Lisa Bradley, David Gallagher, Trudi McDevitt, Andrew J Green
Mutations in BRCA1 and BRCA2 confer a highly increased risk of cancers, mainly of the breast and ovary. Most variants are point mutations or small insertions/deletions detectable by Sanger sequencing. Large genomic rearrangements, including deletions/duplications of multiple exons, are not routinely detectable by Sanger sequencing, but can be reliably identified by Multiplex Ligation-dependent Probe Amplification (MLPA), and account for 5-17% mutations in different populations. Comprehensive mutation testing using these two methods has been facilitated via our centre since 2005...
August 2017: Cancer Genetics
https://www.readbyqxmd.com/read/28593252/standard-vs-expanded-indications-for-esophageal-magnetic-sphincter-augmentation-for-reflux-disease
#19
John P Kuckelman, Cody J Phillips, Mark O Hardin, Matthew J Martin
No abstract text is available yet for this article.
June 7, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28592562/functional-neuroimaging-of-high-risk-6-month-old-infants-predicts-a-diagnosis-of-autism-at-24-months-of-age
#20
Robert W Emerson, Chloe Adams, Tomoyuki Nishino, Heather Cody Hazlett, Jason J Wolff, Lonnie Zwaigenbaum, John N Constantino, Mark D Shen, Meghan R Swanson, Jed T Elison, Sridhar Kandala, Annette M Estes, Kelly N Botteron, Louis Collins, Stephen R Dager, Alan C Evans, Guido Gerig, Hongbin Gu, Robert C McKinstry, Sarah Paterson, Robert T Schultz, Martin Styner, Bradley L Schlaggar, John R Pruett, Joseph Piven
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by social deficits and repetitive behaviors that typically emerge by 24 months of age. To develop effective early interventions that can potentially ameliorate the defining deficits of ASD and improve long-term outcomes, early detection is essential. Using prospective neuroimaging of 59 6-month-old infants with a high familial risk for ASD, we show that functional connectivity magnetic resonance imaging correctly identified which individual children would receive a research clinical best-estimate diagnosis of ASD at 24 months of age...
June 7, 2017: Science Translational Medicine
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