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https://www.readbyqxmd.com/read/28430560/database-centric-method-for-automated-high-throughput-deconvolution-and-analysis-of-kinetic-antibody-screening-data
#1
R Paul Nobrega, Michael Brown, Cody Williams, Chris Sumner, Patricia Estep, Isabelle Caffry, Yao Yu, Heather Lynaugh, Irina Burnina, Asparouh Lilov, Jordan Desroches, John Bukowski, Tingwan Sun, Jonathan P Belk, Kirt Johnson, Yingda Xu
The state-of-the-art industrial drug discovery approach is the empirical interrogation of a library of drug candidates against a target molecule. The advantage of high-throughput kinetic measurements over equilibrium assessments is the ability to measure each of the kinetic components of binding affinity. Although high-throughput capabilities have improved with advances in instrument hardware, three bottlenecks in data processing remain: (1) intrinsic molecular properties that lead to poor biophysical quality in vitro are not accounted for in commercially available analysis models, (2) processing data through a user interface is time-consuming and not amenable to parallelized data collection, and (3) a commercial solution that includes historical kinetic data in the analysis of kinetic competition data does not exist...
April 1, 2017: SLAS Technology
https://www.readbyqxmd.com/read/28428612/granzyme-k-deficient-mice-show-no-evidence-of-impaired-anti-viral-immunity
#2
Lars T Joeckel, Cody C Allison, Mark Pellegrini, Catherina H Bird, Phillip Ian Bird
The biological role of granzyme K, a serine protease of cytotoxic T lymphocytes (CTL), is controversial. It has been reported to induce perforin-mediated cell death in vitro, but is also reported to be non-cytotoxic and to operate in inflammatory processes. To elucidate the biological role of this protease we have deleted the granzyme K gene in mice (mutant allele: Gzmk(tm1.1Pib); MGI:5636646). Gzmk(-/-) mice are healthy, anatomically normal, fecund, and show normal hematopoietic development. Gzmk(-/-) mice readily recover from Lymphocytic choriomeningitis virus and mouse pox Ectromelia virus infection...
April 21, 2017: Immunology and Cell Biology
https://www.readbyqxmd.com/read/28415951/superior-versus-anteroinferior-plating-of-displaced-midshaft-clavicular-fracture-in-patients-older-than-60-years
#3
Minpeng Lu, Hao Qiu, Xin Zhou, Cody S Lee, Dianming Jiang, Jing Dong, Zhengxue Quan
Objective To compare superior versus anteroinferior plating for displaced midshaft clavicular fracture in elderly patients. Methods We retrospectively compared the functional result, parameters, and perioperative course of displaced midshaft clavicular fracture in 42 patients >60 years treated with a 3.5-mm reconstruction plate placed superiorly versus anteroinferiorly. Results Groups were similar with regard to age, sex, bone mineral density, cause of injury, and fracture pattern. The superiorly-plated group had a significantly longer operation time and greater blood loss, complications and implant prominence...
April 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28412161/the-effect-of-the-apneic-period-on-the-respiratory-physiology-of-patients-undergoing-intubation-in-the-emergency-department
#4
Jason R West, Anthony Scoccimarro, Cody Kramer, Nicholas D Caputo
OBJECTIVES: We sought to examine the physiological impact the apneic period has on the respiratory physiology of patients undergoing intubation in the emergency department and whether DAO, the delivery of 15L oxygen by nasal cannula during apnea, can affect the development of respiratory acidosis. METHODS: This was a prospective observational cohort study conducted at an urban academic level 1 trauma center. A convenience sample of 100 patients was taken. Timed data collection forms were completed during the periintubation period...
April 2, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28410443/molecular-characterization-of-volatiles-and-petrochemical-base-oils-by-photo-ionization-gc%C3%A3-gc-tof-ms
#5
Anupam Giri, Marion Coutriade, Amandine Racaud, Koji Okuda, A John Dane, Robert Bernard Cody, Jean-François Focant
The characterization of organic mixtures by comprehensive two-dimensional gas chromatography (GC×GC) coupled to electron impact (EI) ionization time-of-flight mass spectrometry (TOF-MS) allows the detection of thousands of compounds. However, owing to the exhaustive fragmentation following EI ionization, despite the use of mass spectral libraries, a majority of the compounds remains unidentified because of the lack of parent ion preservation. Thus, soft-ionization energies leading to organic compounds being ionized with limited or no fragmentation, retaining the molecular ion, has been of interest for many years...
April 14, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28410018/assessing-the-potential-contributions-of-reduced-immigrant-viability-and-fecundity-to-reproductive-isolation
#6
Cody K Porter, Craig W Benkman
Reduced fitness of immigrants from alternative environments is thought to be an important reproductive isolating barrier. Most studies evaluating the importance of the relative fitness of immigrants to speciation have focused on reduced survival of immigrants (i.e., immigrant inviability). However, variation in fecundity appears to have a greater impact on variation in fitness than does variation in viability, suggesting that reduced fecundity of immigrants could act as an important yet largely overlooked reproductive isolating barrier...
May 2017: American Naturalist
https://www.readbyqxmd.com/read/28408406/a-problem-sorting-task-detects-changes-in-undergraduate-biological-expertise-over-a-single-semester
#7
Anne-Marie Hoskinson, Jessica Middlemis Maher, Cody Bekkering, Diane Ebert-May
Calls for undergraduate biology reform share similar goals: to produce people who can organize, use, connect, and communicate about biological knowledge. Achieving these goals requires students to gain disciplinary expertise. Experts organize, access, and apply disciplinary knowledge differently than novices, and expertise is measurable. By asking introductory biology students to sort biological problems, we investigated whether they changed how they organized and linked biological ideas over one semester of introductory biology...
2017: CBE Life Sciences Education
https://www.readbyqxmd.com/read/28403537/cdspectech-a-single-software-suite-for-multiple-chiroptical-spectroscopic-analyses
#8
Cody L Covington, Prasad L Polavarapu
The program CDSpecTech was developed to facilitate the analysis of chiroptical spectra, which include the following: vibrational circular dichroism (VCD) and corresponding vibrational absorption (VA) spectra; vibrational Raman optical activity (VROA) and corresponding vibrational Raman spectra; electronic circular dichroism (ECD) and corresponding electronic absorption (EA) spectra. In addition, the program allows for generating optical rotatory dispersion (ORD) as the Kramers-Kronig transform of ECD spectra...
April 12, 2017: Chirality
https://www.readbyqxmd.com/read/28401397/documentation-and-treatment-of-intraoperative-hypotension-electronic-anesthesia-records-versus-paper-anesthesia-records
#9
Torin D Shear, Mark Deshur, Brittany Lapin, Steven B Greenberg, Glenn S Murphy, Joseph Szokol, Michael Ujiki, Rebecca Newmark, Jessica Benson, Cody Koress, Connor Dwyer, Jeffery Vender
In this study, we examined anesthetic records before and after the implementation of an electronic anesthetic record documentation (AIMS) in a single surgical population. The purpose of this study was to identify any inconsistencies in anesthetic care based on handwritten documentation (paper) or AIMS. We hypothesized that the type of anesthetic record (paper or AIMS) would lead to differences in the documentation and management of hypotension. Consecutive patients who underwent esophageal surgery between 2009 and 2014 by a single surgeon were eligible for the study...
May 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28401303/evaluation-of-forensic-genetic-parameters-of-12-str-loci-in-the-korean-population-using-the-investigator-%C3%A2-hdplex-kit
#10
Ju Yeon Jung, Eun Hye Kim, Yu-Li Oh, Hyun-Chul Park, Jung Ho Hwang, Si-Keun Lim
We genotyped and calculated the forensic parameters of 10 non-CODIS loci and 2 CODIS loci of 990 Korean individuals using the Investigator(Ⓡ) HDplex kit. No significant deviations from Hardy-Weinberg equilibrium (after Bonferroni correction for multiple testing) or genetic linkage disequilibrium were observed. The calculated matching probability and power of discrimination ranged from 0.0080 to 0.2014, and 0.7986 to 0.9920, respectively. We conclude that the markers of the kit are highly informative corroborative tools for forensic DNA analysis...
April 11, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28399438/internal-validation-of-the-dnascan-ande%C3%A2-rapid-dna-analysis%C3%A2-platform-and-its-associated-powerplex-%C3%A2-16-high-content-dna-biochip-cassette-for-use-as-an-expert-system-with-reference-buccal-swabs
#11
Lilliana I Moreno, Alice L Brown, Thomas F Callaghan
Rapid DNA platforms are fully integrated systems capable of producing and analyzing short tandem repeat (STR) profiles from reference sample buccal swabs in less than two hours. The technology requires minimal user interaction and experience making it possible for high quality profiles to be generated outside an accredited laboratory. The automated production of point of collection reference STR profiles could eliminate the time delay for shipment and analysis of arrestee samples at centralized laboratories...
March 31, 2017: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/28389619/differential-expression-of-oatp1b3-mediates-unconjugated-testosterone-influx
#12
Tristan M Sissung, Ariel M Ley, Jonathan D Strope, Edel M McCrea, Shaunna L Beedie, Cody J Peer, Suneet Shukla, Jennifer C van Velkinburgh, Kelie Reece, Sarah Troutman, Tessa Campbell, Elena Fernandez, Phoebe Huang, Jordan Smith, Nilay Thakkar, David Venzon, Steffan Brenner, Wooin Lee, Maria J Merino, Ji Luo, Walter Jager, Cindy H Chau, Douglas K Price, William D Figg
Castration resistant prostate cancer (CRPC) has greater intratumoral testosterone concentrations than similar tumors from eugonadal men; simple diffusion does not account for this observation. The present study was undertaken to ascertain the androgen uptake kinetics, functional, and clinical relevance of de novo expression of the steroid hormone transporter OATP1B3 (SLCO1B3). Experiments testing the cellular uptake of androgens suggest that testosterone is an excellent substrate of OATP1B3 (KM=23.2µM; VMAX=321...
April 7, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28389570/bves-regulates-c-myc-stability-via-pp2a-and-suppresses-colitis-induced-tumourigenesis
#13
Bobak Parang, Andrew M Kaz, Caitlyn W Barrett, Sarah P Short, Wei Ning, Cody E Keating, Mukul K Mittal, Rishi D Naik, Mary K Washington, Frank L Revetta, J Joshua Smith, Xi Chen, Keith T Wilson, Thomas Brand, David M Bader, William P Tansey, Ru Chen, Teresa A Brentnall, William M Grady, Christopher S Williams
OBJECTIVE: Blood vessel epicardial substance (BVES) is a tight junction-associated protein that regulates epithelial-mesenchymal states and is underexpressed in epithelial malignancy. However, the functional impact of BVES loss on tumourigenesis is unknown. Here we define the in vivo role of BVES in colitis-associated cancer (CAC), its cellular function and its relevance to patients with IBD. DESIGN: We determined BVES promoter methylation status using an Infinium HumanMethylation450 array screen of patients with UC with and without CAC...
May 2017: Gut
https://www.readbyqxmd.com/read/28388294/a-randomized-double-blind-placebo-controlled-trial-to-determine-the-effectiveness-and-safety-of-a-thermogenic-supplement-in-addition-to-an-energy-restricted-diet-in-apparently-healthy-females
#14
Kristina L Kendall, Parker N Hyde, Ciaran M Fairman, Kaitlyn M Hollaway, Petey W Mumford, Cody T Haun, Brooks Mobley, Wesley C Kephart, Aaron C Tribby, Dylan Kimber, Jordan R Moon, Darren T Beck, Michael D Roberts, Kaelin C Young
The increasing interest in weight loss has seen a concurrent rise in the supplemental use of thermogenics to aid weight loss efforts. To date, the effectiveness and safety of supplemental proprietary blend thermogenics, in conjunction with high-protein energy-restricted diets have not been thoroughly evaluated. The purpose of this study was to investigate the efficacy of a low-calorie, high-protein diet with and without the concomitant use of a thermogenic supplement on body weight and body composition in apparently healthy females...
April 7, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28385527/saccharomyces-cerevisiae-hrq1-helicase-activity-is-affected-by-the-sequence-but-not-the-length-of-single-stranded-dna
#15
Cody M Rogers, Matthew L Bochman
Mutations in the human RecQ4 DNA helicase are associated with three different diseases characterized by genomic instability. To gain insight into how RecQ4 dysfunction leads to these pathologies, several groups have used the Saccharomyces cerevisiae RecQ4 homolog Hrq1 as an experimental model. Hrq1 displays many of the same functions as RecQ4 in vivo and in vitro. However, there is some disagreement in the literature about the effects of single-stranded DNA (ssDNA) length on Hrq1 helicase activity and the ability of Hrq1 to anneal complementary ssDNA oligonucleotides into duplex DNA...
April 3, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28383344/effects-of-california-assembly-bill-2109-in-low-vaccination-rate-counties-are-we-looking-at-the-right-variables
#16
Cody Rosentrater, Tracy L Finlayson, K Michael Peddecord
OBJECTIVES: California Assembly Bill 2109 (AB2109) was passed in 2012 and restricted the obtainment of personal belief exemptions (PBEs) for vaccination requirements for school-aged children. This study examined changes in up-to-date (UTD) vaccination rates, PBEs, and conditionally accepted students (CASs) at 3 time points. The study also examined the association of PBEs and CASs on county and school immunization rates. DESIGN: This study utilized 6 academic years of immunization data from all kindergartens in California from 2010-2011 to 2015-2016...
April 4, 2017: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/28382602/effects-of-chamber-pressure-and-partial-pressure-of-water-vapor-on-secondary-drying-in-lyophilization
#17
James A Searles, Sridhar Aravapalli, Cody Hodge
Secondary drying is the final step of lyophilization before stoppering, during which water is desorbed from the product to yield the final moisture content. We studied how chamber pressure and partial pressure of water vapor during this step affected the time course of water content of aqueous solutions of polyvinylpyrrolidone (PVP) in glass vials. The total chamber pressure had no effect when the partial pressure of water vapor was very low. However, when the vapor phase contained a substantial fraction of water vapor, the PVP moisture content was much higher...
April 5, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28382351/the-role-of-coordinated-solvent-on-co-ii-ions-in-tuning-the-single-molecule-magnet-properties-in-a-cody-system
#18
Yan Peng, Valeriu Mereacre, Christopher E Anson, Annie K Powell
Three defect-dicubane coordination clusters related to our previously reported butterfly compound, [Co2Dy2(L)4(NO3)2(THF)2]·4THF (1) and formulated as [Co2Dy2(L)4(NO3)2(MeOH)2]·2CH2Cl2 (2), [Co2Dy2(L)4(NO3)2(DMF)2]·2C2H6CO (3) and [Zn2Dy2(L)4(NO3)2(MeOH)2]·2CH2Cl2 (4) were synthesised and characterised. All show typical SMM behaviour which is steered through the nature of the solvent molecule coordinated to the central 3d ions. The ZnDy, (4) provides experimental proof of the suggestion that in such CoDy compounds two major relaxation pathways can be important in determining the overall magnetic behaviour of Co(II)-4f systems...
April 19, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28379965/tnfa-tnfr2-signaling-is-required-for-glial-ensheathment-at-the-dorsal-root-entry-zone
#19
Cody J Smith, Michael A Wheeler, Lindsay Marjoram, Michel Bagnat, Christopher D Deppmann, Sarah Kucenas
Somatosensory information from the periphery is routed to the spinal cord through centrally-projecting sensory axons that cross into the central nervous system (CNS) via the dorsal root entry zone (DREZ). The glial cells that ensheath these axons ensure rapid propagation of this information. Despite the importance of this glial-axon arrangement, how this afferent nerve is assembled during development is unknown. Using in vivo, time-lapse imaging we show that as centrally-projecting pioneer axons from dorsal root ganglia (DRG) enter the spinal cord, they initiate expression of the cytokine TNFalpha...
April 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28379915/total-knee-arthroplasty-in-patients-with-cerebral-palsy-a-matched-cohort-study-to-patients-with-osteoarthritis
#20
Matthew T Houdek, Chad D Watts, Cody C Wyles, Robert T Trousdale, Todd J Milbrandt, Michael J Taunton
INTRODUCTION: Currently, few data examine the use of total knee arthroplasty (TKA) in patients with cerebral palsy (CP). This study reviewed the outcomes of TKA in patients with CP compared with a matched cohort undergoing TKA for primary osteoarthritis. METHODS: Over a 28-year period, 15 TKAs in patients with a diagnosis of CP were identified. The cohort was 53% men, with a mean age of 58 years. Patients with CP were matched 1:2 based on age, sex, body mass index, and year of surgery with a group of patients undergoing TKA for osteoarthritis...
May 2017: Journal of the American Academy of Orthopaedic Surgeons
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