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https://www.readbyqxmd.com/read/28743177/traditional-suburethral-sling-operations-for-urinary-incontinence-in-women
#1
REVIEW
Haroon Rehman, Carlos A Bezerra, Homero Bruschini, June D Cody, Patricia Aluko
BACKGROUND: Stress urinary incontinence constitutes a significant health and economic burden to society. Traditional suburethral slings are one of the surgical operations used to treat women with symptoms of stress urinary incontinence. OBJECTIVES: To determine the effects of traditional suburethral slings on stress or mixed incontinence in comparison with other management options. SEARCH METHODS: We searched the Cochrane Incontinence Group Specialised Register (searched 3 June 2010) and the reference lists of relevant articles...
July 26, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28741303/open-retropubic-colposuspension-for-urinary-incontinence-in-women
#2
REVIEW
Marie Carmela M Lapitan, June D Cody, Atefeh Mashayekhi
BACKGROUND: Urinary incontinence is a common and potentially debilitating problem. Stress urinary, incontinence as the most common type of incontinence, imposes significant health and economic burdens on society and the women affected. Open retropubic colposuspension is a surgical treatment which involves lifting the tissues near the bladder neck and proximal urethra in the area behind the anterior pubic bones to correct deficient urethral closure to correct stress urinary incontinence...
July 25, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28738443/urethral-injection-therapy-for-urinary-incontinence-in-women
#3
REVIEW
Vivienne Kirchin, Tobias Page, Phil E Keegan, Kofi Om Atiemo, June D Cody, Samuel McClinton, Patricia Aluko
BACKGROUND: Urinary incontinence imposes a significant health and economic burden to society. Periurethral or transurethral injection of bulking agents is a minimally invasive surgical procedure used as one the surgical treatments of stress urinary incontinence (SUI) in adult women. OBJECTIVES: To assess the effects of periurethral or transurethral injection therapy on the cure or improvement of urinary incontinence in women. SEARCH METHODS: We searched the Cochrane Incontinence Group Specialised Trials Register (searched 8 November 2010) and the reference lists of relevant articles...
July 25, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28735800/durability-of-hemiarthroplasty-for-pathologic-proximal-femur-fractures
#4
Matthew T Houdek, Cody C Wyles, Joshua R Labott, Peter S Rose, Michael J Taunton, Franklin H Sim
BACKGROUND: The hip is a common location for metastatic tumors. Due to the high loads placed through the proximal femur, surgery is often indicated to provide pain relief and restore function. Historically, these lesions are reconstructed with a hemiarthroplasty; however, there are few reports on the outcome of these reconstructions. The purpose of this study is to evaluate the outcome of hemiarthroplasty for the treatment of proximal femur metastatic disease, with a specific focus on the rates of conversion to total hip arthroplasty (THA)...
July 5, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28735378/a-phase-i-ii-trial-and-pharmacokinetic-study-of-mithramycin-in-children-and-adults-with-refractory-ewing-sarcoma-and-ews-fli1-fusion-transcript
#5
Patrick J Grohar, John Glod, Cody J Peer, Tristan M Sissung, Fernanda I Arnaldez, Lauren Long, William D Figg, Patricia Whitcomb, Lee J Helman, Brigitte C Widemann
PURPOSE: In a preclinical drug screen, mithramycin was identified as a potent inhibitor of the Ewing sarcoma EWS-FLI1 transcription factor. We conducted a phase I/II trial to determine the dose-limiting toxicities (DLT), maximum tolerated dose (MTD), and pharmacokinetics (PK) of mithramycin in children with refractory solid tumors, and the activity in children and adults with refractory Ewing sarcoma. PATIENTS AND METHODS: Mithramycin was administered intravenously over 6 h once daily for 7 days for 28 day cycles...
July 22, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28733701/copper-ii-complexes-of-bidentate-ligands-exhibit-potent-anti-cancer-activity-regardless-of-platinum-sensitivity-status
#6
Mohamed Wehbe, Cody Lo, Ada W Y Leung, Wieslawa H Dragowska, Gemma M Ryan, Marcel B Bally
Insensitivity to platinum, either through inherent or acquired resistance, is a major clinical problem in the treatment of many solid tumors. Here, we explored the therapeutic potential of diethyldithiocarbamate (DDC), pyrithione (Pyr), plumbagin (Plum), 8-hydroxyquinoline (8-HQ), clioquinol (CQ) copper complexes in a panel of cancer cell lines that differ in their sensitivity to platins (cisplatin/carboplatin) using a high-content imaging system. Our data suggest that the copper complexes were effective against both platinum sensitive (IC50 ~ 1 μM platinum) and insensitive (IC50 > 5 μM platinum) cell lines...
July 21, 2017: Investigational New Drugs
https://www.readbyqxmd.com/read/28727927/technology-components-as-adjuncts-to-family-based-pediatric-obesity-treatment-in-low-income-minority-youth
#7
Gina L Tripicchio, Alice S Ammerman, Cody Neshteruk, Myles S Faith, Kelsey Dean, Christie Befort, Dianne S Ward, Kimberly P Truesdale, Kyle S Burger, Ann Davis
BACKGROUND: Strategies to treat pediatric obesity are needed, especially among high-need populations. Technology is an innovative approach; however, data on technology as adjuncts to in-person treatment programs are limited. METHODS: A total of 64 children [body mass index (BMI) ≥85th percentile, mean age = 9.6 ± 3.1 years, 32.8% female, 84.4% Hispanic] were recruited to participate in one of three cohorts of a family-based behavioral group (FBBG) treatment program: FBBG only, TECH1, and TECH2...
July 20, 2017: Childhood Obesity
https://www.readbyqxmd.com/read/28724437/the-lncrna-casc15-regulates-sox4-expression-in-runx1-rearranged-acute-leukemia
#8
Thilini R Fernando, Jorge R Contreras, Matteo Zampini, Norma I Rodriguez-Malave, Michael O Alberti, Jaime Anguiano, Tiffany M Tran, Jayanth K Palanichamy, Jasmine Gajeton, Nolan M Ung, Cody J Aros, Ella V Waters, David Casero, Giuseppe Basso, Martina Pigazzi, Dinesh S Rao
BACKGROUND: Long non-coding RNAs (lncRNAs) play a variety of cellular roles, including regulation of transcription and translation, leading to alterations in gene expression. Some lncRNAs modulate the expression of chromosomally adjacent genes. Here, we assess the roles of the lncRNA CASC15 in regulation of a chromosomally nearby gene, SOX4, and its function in RUNX1/AML translocated leukemia. RESULTS: CASC15 is a conserved lncRNA that was upregulated in pediatric B-acute lymphoblastic leukemia (B-ALL) with t (12; 21) as well as pediatric acute myeloid leukemia (AML) with t (8; 21), both of which are associated with relatively better prognosis...
July 19, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28721351/cerebral-epidural-abscess-secondary-to-blastomyces-masquerading-as-an-epidermoid-tumor
#9
Cody Doberstein, Abass Noor, David Choi, Jacob Smith, Darren Groh, Leonard Mermel, Curtis Doberstein
There have been infrequent reports of isolated central nervous system blastomycosis. We report a case of intracranial epidural abscess secondary to Blastomyces dermatitidis in a patient residing in Rhode Island with a history of remote travel to an endemic area. The clinical, radiographic, and pathologic features of this unique case are reviewed.
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28713351/a-genome-wide-association-study-to-identify-diagnostic-markers-for-human-pathogenic-campylobacter-jejuni-strains
#10
Cody J Buchanan, Andrew L Webb, Steven K Mutschall, Peter Kruczkiewicz, Dillon O R Barker, Benjamin M Hetman, Victor P J Gannon, D Wade Abbott, James E Thomas, G Douglas Inglis, Eduardo N Taboada
Campylobacter jejuni is a leading human enteric pathogen worldwide and despite an improved understanding of its biology, ecology, and epidemiology, limited tools exist for identifying strains that are likely to cause disease. In the current study, we used subtyping data in a database representing over 24,000 isolates collected through various surveillance projects in Canada to identify 166 representative genomes from prevalent C. jejuni subtypes for whole genome sequencing. The sequence data was used in a genome-wide association study (GWAS) aimed at identifying accessory gene markers associated with clinically related C...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28711360/false-positive-stemi-activations-in-a-regional-network-comprehensive-analysis-and-clinical-impact-results-from-the-catalonian-codi-infart-network
#11
Ander Regueiro, Diego Fernández-Rodríguez, Xavier Freixa, Xavier Bosch, Victoria Martín-Yuste, Salvatore Brugaletta, Mercè Roqué, Manel Sabaté, Mónica Masotti
INTRODUCTION AND OBJECTIVES: ST-segment elevation myocardial infarction (STEMI) network activation by a noncardiologist reduces delay times but may increase the rate of false-positive STEMI diagnoses. We aimed to determine the prevalence, predictors, and clinical impact of false-positive activations within the Catalonian STEMI network (Codi Infart). METHODS: From January 2010 through December 2011, all consecutive patients treated within the Codi Infart network were included...
July 12, 2017: Revista Española de Cardiología
https://www.readbyqxmd.com/read/28711104/a-novel-anesthetic-technique-for-palmar-botulinum-toxin-injection
#12
Stephanie T Le, Cody Hanson, Anand N Rajpara, Deede Y Liu, Daniel J Aires
No abstract text is available yet for this article.
August 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28709828/augmenting-the-efficacy-of-anti-cocaine-catalytic-antibodies-through-chimeric-hapten-design-and-combinatorial-vaccination
#13
Cody J Wenthur, Xiaoqing Cai, Beverly A Ellis, Kim D Janda
Given the need for further improvements in anti-cocaine vaccination strategies, a chimeric hapten (GNET) was developed that combines chemically-stable structural features from steady-state haptens with the hydrolytic functionality present in transition-state mimetic haptens. Additionally, as a further investigation into the generation of an improved bifunctional antibody pool, sequential vaccination with steady-state and transition-state mimetic haptens was undertaken. While GNET induced the formation of catalytically-active antibodies, it did not improve overall behavioral efficacy...
July 5, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28709769/exploring-the-mitochondrial-microrna-import-pathway-through-polynucleotide-phosphorylase-pnpase
#14
Danielle L Shepherd, Quincy A Hathaway, Mark V Pinti, Cody E Nichols, Andrya J Durr, Shruthi Sreekumar, Kristen M Hughes, Seth M Stine, Ivan Martinez, John M Hollander
Cardiovascular disease is the primary cause of mortality for individuals with type 2 diabetes mellitus. During the diabetic condition, cardiovascular dysfunction can be partially attributed to molecular changes in the tissue, including alterations in microRNA (miRNA) interactions. MiRNAs have been reported in the mitochondrion and their presence may influence cellular bioenergetics, creating decrements in functional capacity. In this study, we examined the roles of Argonaute 2 (Ago2), a protein associated with cytosolic and mitochondrial miRNAs, and Polynucleotide Phosphorylase (PNPase), a protein found in the inner membrane space of the mitochondrion, to determine their role in mitochondrial miRNA import...
July 11, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/28707569/imaginative-reinforcement-learning-computational-principles-and-neural-mechanisms
#15
Samuel J Gershman, Jimmy Zhou, Cody Kommers
Imagination enables us not only to transcend reality but also to learn about it. In the context of reinforcement learning, an agent can rationally update its value estimates by simulating an internal model of the environment, provided that the model is accurate. In a series of sequential decision-making experiments, we investigated the impact of imaginative simulation on subsequent decisions. We found that imagination can cause people to pursue imagined paths, even when these paths are suboptimal. This bias is systematically related to participants' optimism about how much reward they expect to receive along imagined paths; providing feedback strongly attenuates the effect...
July 14, 2017: Journal of Cognitive Neuroscience
https://www.readbyqxmd.com/read/28702364/robotic-assisted-common-sheath-ureteroneocystostomy-of-an-injured-ectopic-ureter-diagnosed-in-the-acute-post-operative-setting-after-robotic-assisted-radical-prostatectomy
#16
Matthew Rohloff, Cody Christensen, Thomas Maatman
Radical prostatectomies are one of the most commonly performed operations for the robotic urologist. When a rare anatomic anomaly leads to an unrecognized intraoperative injury, standard postoperative management becomes complicated. We present the case of a patient with an iatrogenic injury to an ectopic ureter that under went a robotic assisted common sheath ureteroneocystostomy three days post robotic assisted radical prostatectomy.
September 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28700810/to-avoid-chasing-incorrect-chemical-structures-of-chiral-compounds-raman-optical-activity-and-vibrational-circular-dichroism-spectroscopies
#17
Prasad L Polavarapu, Cody L Covington, Vijay Raghavan
A chemical structure (CS) identifies the connectivities between atoms, and the nature of those connections, for a given elemental composition. For chiral molecules, in addition to the identification of CS, the identification of the correct absolute configuration (AC) is also needed. Several chiral natural products are known whose CSs were initially mis-identified and later corrected, and these errors were often discovered during the total synthesis of natural products. In this work, we present a new and convenient approach that can be used with Raman optical activity (ROA) and vibrational circular dichroism (VCD) spectroscopies, to distinguish between the correct and incorrect CSs of chiral compounds...
July 12, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28697026/smartphone-based-mobile-thermal-imaging-technology-to-assess-limb-perfusion-and-tourniquet-effectiveness-under-normal-and-blackout-conditions
#18
Morgan R Barron, John P Kuckelman, John M McClellan, Michael J Derickson, Cody J Phillips, Shannon T Marko, Joshua P Smith, Matthew J Eckert, Matthew J Martin
BACKGROUND: Over the past decade there has been a resurgence of tourniquet use in civilian and military settings. Several key challenges include assessment of limb perfusion and adequacy of tourniquet placement, particularly in the austere or pre-hospital environments. We investigated the utility of thermal imaging to assess adequacy of tourniquet placement. METHODS: The FLIR ONE™ smartphone-based thermal imager was utilized. Ten swine underwent tourniquet placement with no associated hemorrhage (n=5) or with 40% hemorrhage (n=5)...
July 8, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28696773/rail-height-effects-on-safety-performance-of-midwest-guardrail-system
#19
Mojdeh Asadollahi Pajouh, Ramen D Julin, Cody S Stolle, John D Reid, Ronald K Faller
OBJECTIVE: Guardrail heights play a crucial role in the way that errant vehicles interact with roadside barriers. Low rail heights increase the propensity of vehicle rollover and override, while excessively-tall rails promote underride. Further, rail mounting heights and post embedment depths may be altered by variations in roadside terrain. An increased guardrail height may be desirable to accommodate construction tolerances, soil erosion, frost heave, and future roadway overlays. This study aimed to investigate and identify a maximum safe installation height for the Midwest Guardrail System, which would be robust and remain crashworthy before and after pavement overlays...
July 11, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28693110/potential-effects-of-brevetoxins-and-toxic-elements-on-various-health-variables-in-kemp-s-ridley-lepidochelys-kempii-and-green-chelonia-mydas-sea-turtles-after-a-red-tide-bloom-event
#20
Justin R Perrault, Nicole I Stacy, Andreas F Lehner, Cody R Mott, Sarah Hirsch, Jonathan C Gorham, John P Buchweitz, Michael J Bresette, Catherine J Walsh
Natural biotoxins and anthropogenic toxicants pose a significant risk to sea turtle health. Documented effects of contaminants include potential disease progression and adverse impacts on development, immune function, and survival in these imperiled species. The shallow seagrass habitats of Florida's northwest coast (Big Bend) serve as an important developmental habitat for Kemp's ridley (Lepidochelys kempii) and green (Chelonia mydas) sea turtles; however, few studies have been conducted in this area. Our objectives were (1) to evaluate plasma analytes (mass, minimum straight carapace length, body condition index [BCI], fibropapilloma tumor score, lysozyme, superoxide dismutase, reactive oxygen/nitrogen species, plasma protein electrophoresis, cholesterol, and total solids) in Kemp's ridleys and green turtles and their correlation to brevetoxins that were released from a red tide bloom event from July-October 2014 in the Gulf of Mexico near Florida's Big Bend, and (2) to analyze red blood cells in Kemp's ridleys and green turtles for toxic elements (arsenic, cadmium, lead, mercury, selenium, thallium) with correlation to the measured plasma analytes...
July 6, 2017: Science of the Total Environment
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