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https://www.readbyqxmd.com/read/29795274/effect-of-physical-activity-on-pulse-wave-velocity-in-elderly-subjects-with-normal-glucose-prediabetes-or-type-2-diabetes
#1
Erja Metsämarttila, Enrique Rodilla, Jari Jokelainen, Sauli Herrala, Juhani Leppäluoto, Sirkka Keinänen-Kiukaanniemi, Karl-Heinz Herzig
Carotid-femoral pulse wave velocity ((cf)PWV) is a measure of arterial stiffness, predicting cardiovascular disease. We hypothesized that the amount of physical activity (PA) is correlated with reduced arterial stiffness in Type 2 diabetic (T2D) subjects. 570 subjects from the 1945 Oulu birth cohort were included in the analysis. (cf)PWV was determined by a non-invasive applanation tonometry. Oral glucose tolerance test was performed and LDL and HDL cholesterol analyzed. PA was registered daily with a wrist-worn acceleration meter for two weeks...
May 23, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29784917/clonal-analysis-of-notch1-expressing-cells-reveals-the-existence-of-unipotent-stem-cells-that-retain-long-term-plasticity-in-the-embryonic-mammary-gland
#2
Anna M Lilja, Veronica Rodilla, Mathilde Huyghe, Edouard Hannezo, Camille Landragin, Olivier Renaud, Olivier Leroy, Steffen Rulands, Benjamin D Simons, Silvia Fre
Recent lineage tracing studies have revealed that mammary gland homeostasis relies on unipotent stem cells. However, whether and when lineage restriction occurs during embryonic mammary development, and which signals orchestrate cell fate specification, remain unknown. Using a combination of in vivo clonal analysis with whole mount immunofluorescence and mathematical modelling of clonal dynamics, we found that embryonic multipotent mammary cells become lineage-restricted surprisingly early in development, with evidence for unipotency as early as E12...
May 21, 2018: Nature Cell Biology
https://www.readbyqxmd.com/read/29594177/2018-international-olympic-committee-consensus-statement-on-prevention-diagnosis-and-management-of-pediatric-anterior-cruciate-ligament-injuries
#3
Clare L Ardern, Guri Ekås, Hege Grindem, Håvard Moksnes, Allen F Anderson, Franck Chotel, Moises Cohen, Magnus Forssblad, Theodore J Ganley, Julian A Feller, Jón Karlsson, Mininder S Kocher, Robert F LaPrade, Mike McNamee, Bert Mandelbaum, Lyle Micheli, Nicholas G H Mohtadi, Bruce Reider, Justin P Roe, Romain Seil, Rainer Siebold, Holly J Silvers-Granelli, Torbjørn Soligard, Erik Witvrouw, Lars Engebretsen
In October 2017, the International Olympic Committee hosted an international expert group of physical therapists and orthopaedic surgeons who specialize in treating and researching pediatric anterior cruciate ligament (ACL) injuries. The purpose of this meeting was to provide a comprehensive, evidence-informed summary to support the clinician and help children with ACL injury and their parents/guardians make the best possible decisions. Representatives from the following societies attended: American Orthopaedic Society for Sports Medicine; European Paediatric Orthopaedic Society; European Society for Sports Traumatology, Knee Surgery, and Arthroscopy; International Society of Arthroscopy, Knee Surgery and Orthopaedic Sports Medicine; Pediatric Orthopaedic Society of North America; and Sociedad Latinoamericana de Artroscopia, Rodilla, y Deporte...
March 2018: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29519537/positioning-document-on-incorporating-point-of-care-ultrasound-in-internal-medicine-departments
#4
J Torres Macho, F J García Sánchez, P Garmilla Ezquerra, L Beltrán Romero, J Canora Lebrato, J M Casas Rojo, P Arribas Arribas, S López Palmero, S Pintos Martínez, J M Cepeda Rodrigo, D Luordo, M Beltrán López, M Méndez Bailón, E Rodilla Sala, L Manzano Espinosa, A Zapatero Gaviria, G García de Casasola
This positioning document describes the most important aspects of clinical ultrasonography in the internal medicine setting, from its fundamental indications to the recommended training period. There is no question as to the considerable usefulness of this tool in the standard clinical practice of internists in numerous clinical scenarios and settings (emergencies, hospital ward, general and specific consultations and home care). Ultrasonography has a relevant impact on the practitioner's ability to resolve issues, increasing diagnostic reliability and safety and providing important information on the prognosis and progression...
May 2018: Revista Clínica Española
https://www.readbyqxmd.com/read/29478021/2018-international-olympic-committee-consensus-statement-on-prevention-diagnosis-and-management-of-paediatric-anterior-cruciate-ligament-acl-injuries
#5
Clare L Ardern, Guri Ranum Ekås, Hege Grindem, Håvard Moksnes, Allen F Anderson, Franck Chotel, Moises Cohen, Magnus Forssblad, Theodore J Ganley, Julian A Feller, Jón Karlsson, Minider S Kocher, Robert F LaPrade, Michael McNamee, Bert Mandelbaum, Lyle Micheli, Nicholas Mohtadi, Bruce Reider, Justin Roe, Romain Seil, Rainer Siebold, Holly J Silvers-Granelli, Torbjørn Soligard, Erik Witvrouw, Lars Engebretsen
In October 2017, the International Olympic Committee hosted an international expert group of physiotherapists and orthopaedic surgeons who specialise in treating and researching paediatric ACL injuries. Representatives from the American Orthopaedic Society for Sports Medicine, European Paediatric Orthopaedic Society, European Society for Sports Traumatology, Knee Surgery & Arthroscopy, International Society of Arthroscopy Knee Surgery and Orthopaedic Sports Medicine, Pediatric Orthopaedic Society of North America and Sociedad Latinoamericana de Artroscopia, Rodilla y Deporte attended...
April 2018: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/29465401/real-life-evaluation-of-the-degree-of-compliance-to-recommendations-of-anaphylaxis-guidelines-in-an-emergency-department-of-a-tertiary-hospital
#6
L V Ponce Guevara, E Laffond Yges, M T Gracia Bara, E Moreno Rodilla, F J Muñoz Bellido, M Lázaro Sastre, E M Macías Iglesias, S de Arriba Méndez, M V Campanón Toro, I Dávila Gónzalez
BACKGROUND AND OBJECTIVE: To date, few studies have evaluated the degree of compliance with recommendations of anaphylaxis guidelines in emergency departments (EDs). Objective: The objective of this study was to evaluate adherence to anaphylaxis guidelines recommendations in an ED of a tertiary hospital. METHODS: Medical records of patients that were assisted in the ED of the University Hospital of Salamanca (Spain) were reviewed. Those patients fulfilling anaphylaxis criteria proposed by the NIAID/FAAN were selected...
February 21, 2018: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/29455243/2018-international-olympic-committee-consensus-statement-on-prevention-diagnosis-and-management-of-paediatric-anterior-cruciate-ligament-acl-injuries
#7
REVIEW
Clare L Ardern, Guri Ekås, Hege Grindem, Håvard Moksnes, Allen Anderson, Franck Chotel, Moises Cohen, Magnus Forssblad, Theodore J Ganley, Julian A Feller, Jón Karlsson, Mininder S Kocher, Robert F LaPrade, Mike McNamee, Bert Mandelbaum, Lyle Micheli, Nicholas Mohtadi, Bruce Reider, Justin Roe, Romain Seil, Rainer Siebold, Holly J Silvers-Granelli, Torbjørn Soligard, Erik Witvrouw, Lars Engebretsen
In October 2017, the International Olympic Committee hosted an international expert group of physiotherapists and orthopaedic surgeons who specialise in treating and researching paediatric anterior cruciate ligament (ACL) injuries. Representatives from the American Orthopaedic Society for Sports Medicine, European Paediatric Orthopaedic Society, European Society for Sports Traumatology, Knee Surgery and Arthroscopy, International Society of Arthroscopy Knee Surgery and Orthopaedic Sports Medicine, Pediatric Orthopaedic Society of North America, and Sociedad Latinoamericana de Artroscopia, Rodilla y Deporte attended...
April 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29134554/ex-vivo-rabbit-cornea-diffusion-studies-with-a-soluble-insert-of-moxifloxacin
#8
María Sebastián-Morelló, María Aracely Calatayud-Pascual, Vicent Rodilla, Cristina Balaguer-Fernández, Alicia López-Castellano
The objective of this research was to develop and evaluate an ocular insert for the controlled drug delivery of moxifloxacin which could perhaps be used in the treatment of corneal keratitis or even bacterial endophthalmitis. We have evaluated the ex vivo ocular diffusion of moxifloxacin through rabbit cornea, both fresh and preserved under different conditions. Histological studies were also carried out. Subsequently, drug matrix inserts were prepared using bioadhesive polymers. The inserts were evaluated for their physicochemical parameters...
February 2018: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29099994/-the-occupational-physician-s-role-in-the-detection-and-official-recognition-of-occupational-skin-diseases
#9
Rocío Villar Vinuesa, José Mª Ramada Rodilla, Consol Serra Pujadas
Occupational and work-related skin diseases include all skin conditions (as well as those involving the mucous membranes and cutaneous annexes) that are caused, conditioned, aggravated or promoted directly or indirectly by workplace risk factors. Occupational health physicians (OP) are involved in all phases of the natural history of the disease: prevention, early detection, diagnosis, clinical management, and providing advice and support to the company and the worker in all these stages. This paper provides an in-depth review of the role of the OP throughout this process, underscoring the importance of coordination with the dermatologist and/or the allergist...
October 2017: Archivos de Prevención de Riesgos Laborales
https://www.readbyqxmd.com/read/29099993/-self-perceived-work-disability-in-a-school-of-children-with-special-needs
#10
Mª Del Mar Seguí Crespo, Mª Isabel Martínez Gracia, Mª José Molina Torres, José Mª Ramada Rodilla
AIMS: Increased psychosocial and physical demands of the Special Education Centers (SEC) workers can also lead to intense involvement, triggering stressful and to trigger stress situations and potentially work disability. The objective of this study was to assess the self-perceived occupational disability and its relation with socio-demographic, occupational and health variables with in a sample of this these workers. METHODS: Cross-sectional study with of 40 SEC workers of in Murcia (Spain) (n = 40)...
October 2017: Archivos de Prevención de Riesgos Laborales
https://www.readbyqxmd.com/read/29061725/relationship-between-24-hour-ambulatory-central-systolic-blood-pressure-and-left-ventricular-mass-a-prospective-multicenter-study
#11
MULTICENTER STUDY
Thomas Weber, Siegfried Wassertheurer, Arno Schmidt-Trucksäss, Enrique Rodilla, Cornelia Ablasser, Piotr Jankowski, Maria Lorenza Muiesan, Cristina Giannattasio, Claudia Mang, Ian Wilkinson, Jörg Kellermair, Bernhard Hametner, Jose Maria Pascual, Robert Zweiker, Danuta Czarnecka, Anna Paini, Massimo Salvetti, Alessandro Maloberti, Carmel McEniery
We investigated the relationship between left ventricular mass and brachial office as well as brachial and central ambulatory systolic blood pressure in 7 European centers. Central systolic pressure was measured with a validated oscillometric device, using a transfer function, and mean/diastolic pressure calibration. M-mode images were obtained by echocardiography, and left ventricular mass was determined by one single reader blinded to blood pressure. We studied 289 participants (137 women) free from antihypertensive drugs (mean age: 50...
December 2017: Hypertension
https://www.readbyqxmd.com/read/28833710/factors-associated-with-self-medication-in-spain-a-cross-sectional-study-in-different-age-groups
#12
Gracia Niclós, Teresa Olivar, Vicent Rodilla
OBJECTIVE: The identification of factors which may influence a patient's decision to self-medicate. METHODS: Descriptive, cross-sectional study of the adult population (at least 16 years old), using data from the 2009 European Health Interview Survey in Spain, which included 22 188 subjects. Logistic regression models enabled us to estimate the effect of each analysed variable on self-medication. KEY FINDINGS: In total, 14 863 (67%) individuals reported using medication (prescribed and non-prescribed) and 3274 (22...
August 17, 2017: International Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28795462/a-cross-sectional-evaluation-of-the-prevalence-and-detection-of-predictors-of-polypharmacy-amongst-adult-in-spain
#13
Gracia Niclós, Teresa Olivar, Vicent Rodilla
OBJECTIVE: To investigate the association between polypharmacy and sociodemographic factors as well as health status, determinants of health and healthcare use, illness and use of prescribed medicines amongst adults in Spain. METHODS: Data from the 2009 European Health Interview Survey in Spain which included 22 188 subjects were used. Polypharmacy was defined as the use of five or more prescribed medicines. The association between polypharmacy and several variables was assessed by means of bivariate analysis and logistic regression analysis (adjusted by age and gender)...
August 10, 2017: International Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28709670/arterial-stiffness-in-normotensive-and-hypertensive-subjects-frequency-in-community-pharmacies
#14
Enrique Rodilla Sala, Manuel Adell Alegre, Vicente Giner Galvañ, Zeneida Perseguer Torregrosa, Jose Maria Pascual Izuel, María Teresa Climent Catalá
BACKGROUND AND OBJECTIVE: Arterial stiffness (AS) is a well-recognized target organ lesion. This study aims to determine: 1) the frequency of AS in community pharmacies; 2) if stiffened subjects identified by brachial oscillometry have more CV risk factors than normal subjects, and 3) the dependence of stiffness on using either age-adjusted values or a fixed threshold. PATIENTS AND METHOD: Observational, cross-sectional study in 32 community pharmacies of the Valencia Community, between November/2015 and April/2016...
July 11, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28656731/occupational-skin-diseases-actual-state-analysis-of-patient-management-pathways-in-28-european-countries
#15
V Mahler, K Aalto-Korte, J H Alfonso, J G Bakker, A Bauer, L Bensefa-Colas, A Boman, J Bourke, M Bubaš, P Bulat, J Chaloupka, L Constandt, T E Danielsen, R Darlenski, A Dugonik, K Ettler, A Gimenez-Arnau, M Gonçalo, J D Johansen, S M John, M Kiec-Swierczynska, P Koch, V Kohánka, B Krecisz, F Larese Filon, S Ljubojević, J Macan, B Marinović, M Matura, P W Mihatsch, D Mijakoski, J Minov, J Pace, M Pesonen, J M Ramada Rodilla, H Rast, V Reljic, C Salavastru, C Schuster, M L Schuttelaar, D Simon, R Spiewak, R Jurakic Tončić, S Urbanček, S Valiukevičienė, P Weinert, M Wilkinson, W Uter
BACKGROUND: Work-related skin diseases (WSD) are caused or worsened by a professional activity. Occupational skin diseases (OSD) need to fulfil additional legal criteria which differ from country to country. OSD range amongst the five most frequently notified occupational diseases (musculoskeletal diseases, neurologic diseases, lung diseases, diseases of the sensory organs, skin diseases) in Europe. OBJECTIVE: To retrieve information and compare the current state of national frameworks and pathways to manage patients with occupational skin disease with regard to prevention, diagnosis, treatment and rehabilitation in different European countries...
June 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28656728/minimum-standards-on-prevention-diagnosis-and-treatment-of-occupational-and-work-related-skin-diseases-in-europe-position-paper-of-the-cost-action-standerm-td-1206
#16
J H Alfonso, A Bauer, L Bensefa-Colas, A Boman, M Bubas, L Constandt, M N Crepy, M Goncalo, J Macan, V Mahler, D Mijakoski, J M Ramada Rodilla, T Rustemeyer, P Spring, S M John, W Uter, M Wilkinson, A M Giménez-Arnau
BACKGROUND: Skin diseases constitute up to 40% of all notified occupational diseases in most European countries, predominantly comprising contact dermatitis, contact urticaria, and skin cancer. While insufficient prevention of work-related skin diseases (WRSD) is a top-priority problem in Europe, common standards for prevention of these conditions are lacking. OBJECTIVE: To develop common European standards on prevention and management of WRSD and occupational skin diseases (OSD)...
June 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28547208/pulse-wave-velocity-and-augmentation-index-are-not-independently-associated-with-carotid-atherosclerosis-in-patients-with-rheumatoid-arthritis
#17
M Robustillo-Villarino, J J Alegre-Sancho, E Rodilla-Sala, A Corrales, J Llorca, M A Gonzalez-Gay, P H Dessein
Arterial stiffness can enhance cardiovascular risk by increasing atherogenesis or adverse hemodynamic effects. We examined whether the arterial stiffness markers of aortic pulse wave velocity (PWV) and the augmentation index (AIx) are independently associated with carotid artery intima-media thickness (IMT) and plaque in patients with rheumatoid arthritis (RA). PWV and AIx were determined by brachial oscillometry using the Mobil-O-Graph® system and carotid IMT and plaque by ultrasound in 194 consecutive RA patients without established cardiovascular disease, chronic kidney disease, and diabetes at disease onset...
November 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28495320/comparison-of-2-intravenous-insulin-protocols-glycemia-variability-in-critically-ill-patients
#18
Marta Gómez-Garrido, Ana M Rodilla-Fiz, María Girón-Lacasa, Laura Rodríguez-Rubio, Anselmo Martínez-Blázquez, Fernando Martínez-López, María Dolores Pardo-Ibáñez, Juan M Núñez-Marín
OBJECTIVE: Glycemic variability is an independent predictor of mortality in critically ill patients. The objective of this study was to compare two intravenous insulin protocols in critically ill patients regarding the glycemic variability. MATERIAL AND METHODS: This was a retrospective observational study performed by reviewing clinical records of patients from a Critical Care Unit for 4 consecutive months. First, a simpler Scale-Based Intravenous Insulin Protocol (SBIIP) was reviewed and later it was compared for the same months of the following year with a Sliding Scale-Based Intravenous Insulin Protocol (SSBIIP)...
May 2017: Endocrinología, Diabetes y Nutrición
https://www.readbyqxmd.com/read/28396364/novel-indole-based-tambjamine-analogues-induce-apoptotic-lung-cancer-cell-death-through-p38-mitogen-activated-protein-kinase-activation
#19
Pilar Manuel-Manresa, Luís Korrodi-Gregório, Elsa Hernando, Alberto Villanueva, David Martínez-García, Ananda M Rodilla, Ricard Ramos, Margarida Fardilha, Juan Moya, Roberto Quesada, Vanessa Soto-Cerrato, Ricardo Pérez-Tomás
Lung cancer has become the leading killer cancer worldwide, due to late diagnosis and lack of efficient anticancer drugs. We have recently described novel natural-derived tambjamine analogues that are potent anion transporters capable of disrupting cellular ion balance, inducing acidification of the cytosol and hyperpolarization of cellular plasma membranes. Although these tambjamine analogues were able to compromise cell survival, their molecular mechanism of action remains largely unknown. Herein we characterize the molecular cell responses induced by highly active indole-based tambjamine analogues treatment in lung cancer cells...
July 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28219654/worry-inducing-stimuli-in-an-aversive-go-nogo-task-enhance-reactive-control-in-individuals-with-lower-trait-anxiety
#20
Anja Leue, Carmen Cano Rodilla, André Beauducel
This study relates predictions on reactive and proactive cognitive control to findings on anxious apprehension/worry and ERN/Ne. We investigated whether worry-inducing stimuli in an aversive performance setting lead to a more pronounced increase of the ERN/Ne in individuals with lower anxious apprehension/worry. We also explored the N2 amplitude in the context of worry-inducing stimuli. Fifty-eight participants performed an extended Go/NoGo task. A neutral or fearful face was presented at the beginning of each trial, with the fearful face as a worry-inducing, distracting stimulus...
April 2017: Biological Psychology
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