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https://www.readbyqxmd.com/read/28495320/comparison-of-2-intravenous-insulin-protocols-glycemia-variability-in-critically-ill-patients
#1
Marta Gómez-Garrido, Ana M Rodilla-Fiz, María Girón-Lacasa, Laura Rodríguez-Rubio, Anselmo Martínez-Blázquez, Fernando Martínez-López, María Dolores Pardo-Ibáñez, Juan M Núñez-Marín
OBJECTIVE: Glycemic variability is an independent predictor of mortality in critically ill patients. The objective of this study was to compare two intravenous insulin protocols in critically ill patients regarding the glycemic variability. MATERIAL AND METHODS: This was a retrospective observational study performed by reviewing clinical records of patients from a Critical Care Unit for 4 consecutive months. First, a simpler Scale-Based Intravenous Insulin Protocol (SBIIP) was reviewed and later it was compared for the same months of the following year with a Sliding Scale-Based Intravenous Insulin Protocol (SSBIIP)...
May 2017: Endocrinol Diabetes Nutr
https://www.readbyqxmd.com/read/28396364/novel-indole-based-tambjamine-analogues-induce-apoptotic-lung-cancer-cell-death-through-p38-mitogen-activated-protein-kinase-activation
#2
Pilar Manuel-Manresa, Luís Korrodi-Gregório, Elsa Hernando, Alberto Villanueva, David Martínez-García, Ananda M Rodilla, Ricard Ramos, Margarida Fardilha, Juan Moya, Roberto Quesada, Vanessa Soto-Cerrato, Ricardo Perez-Tomas
Lung cancer has become the leading killer cancer worldwide, due to late diagnosis and lack of efficient anticancer drugs. We have recently described novel natural-derived tambjamine analogues that are potent anion transporters capable of disrupting cellular ion balance, inducing acidification of the cytosol and hyperpolarization of cellular plasma membranes. Although these tambjamine analogues were able to compromise cell survival, their molecular mechanism of action remains largely unknown. Herein we characterize the molecular cell responses induced by highly active indole-based tambjamine analogues treatment in lung cancer cells...
April 10, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28219654/worry-inducing-stimuli-in-an-aversive-go-nogo-task-enhance-reactive-control-in-individuals-with-lower-trait-anxiety
#3
Anja Leue, Carmen Cano Rodilla, André Beauducel
This study relates predictions on reactive and proactive cognitive control to findings on anxious apprehension/worry and ERN/Ne. We investigated whether worry-inducing stimuli in an aversive performance setting lead to a more pronounced increase of the ERN/Ne in individuals with lower anxious apprehension/worry. We also explored the N2 amplitude in the context of worry-inducing stimuli. Fifty-eight participants performed an extended Go/NoGo task. A neutral or fearful face was presented at the beginning of each trial, with the fearful face as a worry-inducing, distracting stimulus...
February 17, 2017: Biological Psychology
https://www.readbyqxmd.com/read/28126195/traumatic-thoracoplasty-conservative-treatment-or-surgery
#4
María Garví López, Ana M Rodilla Fiz, M Belén Lozano Serrano
No abstract text is available yet for this article.
May 2017: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/28010121/emotional-eating-as-a-mediator-between-anxiety-and-cholesterol-in-population-with-overweight-and-hypertension
#5
Marinna S Mensorio, Ausiàs Cebolla, Juan Francisco Lisón, Enrique Rodilla, Gonzalo Palomar, Marta Miragall, Rosa Maria Baños
Although the relationship between cholesterol and mood states (especially anxiety) has been well studied, few researches have included the role of eating styles in this relationship. This study explored the associations among eating styles, negative emotional symptoms, and levels of cholesterol (and other medical variables) in a population with hypertension and overweight or obesity, analyzing the possible mediation mechanisms involved. A cross-sectional study was conducted in 68 adults with hypertension and overweight/obesity, and stepwise multiple regression analysis and mediation analyses were carried out to test the hypothesis that eating styles mediate the relationship between negative emotional symptoms and cholesterol...
December 23, 2016: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/27993838/arterial-destiffening-in-previously-untreated-mild-hypertensives-after-1-year-of-routine-clinical-management
#6
Enrique Rodilla, Sandrine Millasseau, Jose Antonio Costa, Jose Maria Pascual
BACKGROUND: Arterial stiffness, measured with pulse wave velocity (PWV), is now classified as a marker of target organ damage (TOD) alongside left ventricular hypertrophy and moderately increased albuminuria. Interventional studies on treated hypertensive patients have shown that PWV could be improved. Our aim was to assess changes in arterial stiffness after 1 year of routine clinical practice in never-treated hypertensive patients. PATIENTS AND METHODS: We studied 356 never-treated patients with suspected hypertension...
May 1, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/27890727/synthetic-tambjamine-analogues-induce-mitochondrial-swelling-and-lysosomal-dysfunction-leading-to-autophagy-blockade-and-necrotic-cell-death-in-lung-cancer
#7
Ananda M Rodilla, Luís Korrodi-Gregório, Elsa Hernando, Pilar Manuel-Manresa, Roberto Quesada, Ricardo Pérez-Tomás, Vanessa Soto-Cerrato
Current pharmacological treatments for lung cancer show very poor clinical outcomes, therefore, the development of novel anticancer agents with innovative mechanisms of action is urgently needed. Cancer cells have a reversed pH gradient compared to normal cells, which favours cancer progression by promoting proliferation, metabolic adaptation and evasion of apoptosis. In this regard, the use of ionophores to modulate intracellular pH appears as a promising new therapeutic strategy. Indeed, there is a growing body of evidence supporting ionophores as novel antitumour drugs...
February 15, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/27855253/-musculoskeletal-disorders-and-temporary-disability-characteristics-and-duration-catalonia-2007-2010
#8
Ignasi Manent Bistué, José Mª Ramada Rodilla, Consol Serra Pujadas
BACKGROUND: Musculoskeletal disorders (MSD) are the leading cause of sickness absence (SA) in Spain and the second in Catalonia. A greater knowledge of this field could allow the refocusing of social protection policies and interventions to reduce their frequency and duration. The objective of the study was to describe the characteristics and duration of SA due to MSD in Catalonia between 2007 and 2010. METHODS: The study population included all incident SA episodes due to MSD during the period 2007-2010, registered in the Institut Català d'AvaluacionsMèdiques (ICAM) database...
October 2016: Archivos de Prevención de Riesgos Laborales
https://www.readbyqxmd.com/read/27835822/woven-coronary-artery-anomaly-presenting-as-sudden-cardiac-death
#9
José-Fernando Val-Bernal, Séfora Malaxetxebarria, Irene González-Rodilla, Miguel Salas-García
Woven coronary artery is a rare anomaly characterized by thin channels arising from the coronary artery and reanastomosing at the distal arterial segment. To our knowledge, no data are available currently on the histologic structure of the woven segment. A 39-year-old man presented with sudden atypical chest pain while he was practicing cycling. During the transfer of the patient to the hospital, he suffered cardiac arrest. After 50 min of cardiopulmonary resuscitation, the patient could not return to sinus rhythm and died...
January 2017: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/27777848/antibacterial-and-antioxidant-activity-of-portuguese-lavandula-luisieri-rozeira-rivas-martinez-and-its-relation-with-their-chemical-composition
#10
Sofia Pombal, Cleide F Rodrigues, João P Araújo, Pedro M Rocha, Jesus M Rodilla, David Diez, Ángela P Granja, Arlindo C Gomes, Lúcia A Silva
Lavandula luisieri (Rozeira) Rivas-Martinez is an endemic aromatic Labiatae the Iberian Peninsula, common in semi-arid regions of southern Portugal and southwestern Spain, that produces an active antibacterial essential oil from the leaves and flowers. This work presents the study of the chemical variation in various stages of growth of leaves and flowers of L. luisieri. It has been found that the essential oils are mainly constituted by 1,8-cineol, camphor, linalool and trans-α-necrodil acetate. It was also studied the total phenol content and the antioxidant activity on leaves and flowers...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27754043/os-13-09-relationship-between-24-hour-ambulatory-central-blood-pressure-and-left-ventricular-mass-a-prospective-multicenter-study
#11
Thomas Weber, Siegfried Wassertheurer, Enrique Rodilla Sala, Cornelia Ablasser, Piotr Jankowski, Maria Lorenza Muisan, Cristina Giannatasio, Claudia Mang, Arno Schmidt-Trucksäss, Ian Wilkinson, Carmel McEniery
OBJECTIVE: To investigate the relationship between left ventricular mass (LVM) and brachial office systolic blood pressure (bOSBP), brachial 24 hours ambulatory SBP (bASBP) and central 24 hours ambulatory SBP (cASBP). DESIGN AND METHOD: In 7 European centers, bASBP was measured with a validated automated oscillometric device (mobilograph, i.e.m., Stolberg, Germany). cASBP was determined, using a transfer function, and mean/diastolic BP calibration. M-mode images were obtained by echocardiography, and LVM was determined by one single reader according to standard guidelines and normalized to body surface area...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27708571/error-related-negativity-and-the-misattribution-of-state-anxiety-following-errors-on-the-reproducibility-of-inzlicht-and-al-khindi
#12
Carmen Cano Rodilla, André Beauducel, Anja Leue
In their innovative study, Inzlicht and Al-Khindi (2012) demonstrated that participants who were allowed to misattribute their arousal and negative affect induced by errors to a placebo beverage had a reduced error-related negativity (ERN/Ne) compared to controls not being allowed to misattribute their arousal following errors. These results contribute to the ongoing debate that affect and motivation are interwoven with the cognitive processing of errors. Evidence that the misattribution of negative affect modulates the ERN/Ne is essential for understanding the mechanisms behind ERN/Ne...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27642963/os-13-09-relationship-between-24-hour-ambulatory-central-blood-pressure-and-left-ventricular-mass-a-prospective-multicenter-study
#13
Thomas Weber, Siegfried Wassertheurer, Enrique Rodilla Sala, Cornelia Ablasser, Piotr Jankowski, Maria Lorenza Muisan, Cristina Giannatasio, Claudia Mang, Arno Schmidt-Trucksäss, Ian Wilkinson, Carmel McEniery
OBJECTIVE: To investigate the relationship between left ventricular mass (LVM) and brachial office systolic blood pressure (bOSBP), brachial 24 hours ambulatory SBP (bASBP) and central 24 hours ambulatory SBP (cASBP). DESIGN AND METHOD: In 7 European centers, bASBP was measured with a validated automated oscillometric device (mobilograph, i.e.m., Stolberg, Germany). cASBP was determined, using a transfer function, and mean/diastolic BP calibration. M-mode images were obtained by echocardiography, and LVM was determined by one single reader according to standard guidelines and normalized to body surface area...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27575529/-arterial-hypertension-and-prediabetes
#14
Patricia Boned Ombuena, Enrique Rodilla Sala, José Antonio Costa Muñoz, José María Pascual Izuel
BACKGROUND AND OBJECTIVES: The aim of this study was to assess the factors related to new diabetes in hypertensive. PATIENTS AND METHODS: This prospective follow-up study involved 2588 non-diabetic, hypertensive patients. The total follow-up was 15053 patient-years with a median of 3.4 years (interquartile interval 1.4-6.8). RESULTS: During the follow-up 333 (13%) patients had new diabetes, with a conversion rate of 2.21 (95% confidence interval [CI], 1...
November 4, 2016: Medicina Clínica
https://www.readbyqxmd.com/read/27508788/-op-6c-06-fixed-dosed-combinations-of-arb-are-superior-to-extemporaneous-combinations-in-reducing-total-mortality-and-cardiovascular-morbidity
#15
E Rodilla Sala, R Maroto, F Lobo, J M Pascual
OBJECTIVE: Control of HTN remains unsatisfactory in the majority of hypertensive patients, even after introduction of multidrug therapeutic strategies. Newly developed treatments based on fixed-dosed combinations (FDC) of complementary drugs are said to improve control. This study aims to compare the efficacy of FDC versus extemporaneous combinations on total mortality and cardiovascular morbidity in a real-life setting. DESIGN AND METHOD: Post-observational, descriptive, longitudinal, retrospective study in Primary Care of the Valencian Community, including 181...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27435956/muckle-wells-syndrome-a-case-report-with-an-nlrp3-t348m-mutation
#16
Elena Naz Villalba, Enrique Gomez de la Fuente, Dolores Caro Gutierrez, Fernando Pinedo Moraleda, Julio Yanguela Rodilla, Diana Mazagatos Angulo, Jose Luis López Estebaranz
Autoinflammatory syndromes are a recently described group of conditions caused by mutations in multiple genes that code for proteins of the innate immune system. Cryopyrin-associated periodic syndromes are autoinflammatory diseases comprising three clinically overlapping disorders: familial cold urticaria syndrome, Muckle-Wells syndrome (MWS), and neonatal-onset multisystem inflammatory disease. MWS is characterized by a moderate phenotype with fever, rash, arthralgia, conjunctivitis, sensorineural deafness, and potentially life-threatening amyloidosis...
September 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27399222/predictive-capacity-of-cloninger-s-temperament-and-character-inventory-tci-r-in-alcohol-use-disorder-outcomes
#17
José Juan Ávila Escribano, Mercedes Sánchez Barba, Aida Álvarez Pedrero, Ana López Villarreal, Joaquina Recio Pérez, Manuela Rodríguez Rodilla, Eulalia Fraile García
OBJECTIVE: to investigate the ability to predict the outcome of alcohol use disorders through Cloninger's temperament and character inventory (TCI-R). METHODS: this is a prospective study consisting of 237 outpatients with alcohol use disorders who underwent follow-up treatment for 6 months and whose personality traits were studied using TCI-R. At the end of that period, the scores of each TCI-R trait were analyzed in terms of those who remained in treatment and those who dropped out...
June 14, 2016: Adicciones
https://www.readbyqxmd.com/read/27376533/effects-of-improved-fat-meat-products-consumption-on-emergent-cardiovascular-disease-markers-of-male-volunteers-at-cardiovascular-risk
#18
Paloma Celada, Francisco J Sánchez-Muniz, Gonzalo Delgado-Pando, Sara Bastida, Manuel Espárrago Rodilla, Francisco Jiménez-Colmenero, Begoña Olmedilla-Alonso
High meat-product consumption has been related to cardiovascular disease (CVD). However, previous results suggest the benefits of consuming improved fat meat products on lipoprotein-cholesterol and anthropometric measurements. Present study aims to assess the effect of consuming different Pâté and Frankfurter formulations on emergent CVD biomarkers in male volunteers at increased CVD risk. Eighteen male volunteers with at least two CVD risk factors were enrolled in a sequentially controlled study where different pork-products were tested: reduced-fat (RF), omega-3-enriched-RF (n-3RF), and normal-fat (NF)...
December 2016: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/27326981/clinical-practice-guidelines-for-diagnosis-and-management-of-hypersensitivity-reactions-to-contrast-media
#19
REVIEW
A Rosado Ingelmo, I Doña Diaz, R Cabañas Moreno, M C Moya Quesada, C García-Avilés, I García Nuñez, J I Martínez Tadeo, R Mielgo Ballesteros, N Ortega-Rodríguez, M A Padial Vilchez, L Sánchez-Morillas, C Vila Albelda, E Moreno Rodilla, M J Torres Jaén
The objective of these guidelines is to ensure efficient and effective clinical practice. The panel of experts who produced this consensus document developed a research protocol based on a review of the literature. The prevalence of allergic reactions to iodinated contrast media (ICM) is estimated to be 1:170 000, that is, 0.05%-0.1% of patients undergoing radiologic studies with ICM (more than 75 million examinations per year worldwide). Hypersensitivity reactions can appear within the first hour after administration (immediate reactions) or from more than 1 hour to several days after administration (nonimmediate or delayed reactions)...
2016: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/27307493/efficient-nuclear-export-of-p65-i%C3%AE%C2%BAb%C3%AE-complexes-requires-14-3-3-proteins
#20
Cristina Aguilera, Vanessa Fernández-Majada, Julia Inglés-Esteve, Verónica Rodilla, Anna Bigas, Lluís Espinosa
No abstract text is available yet for this article.
June 15, 2016: Journal of Cell Science
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