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https://www.readbyqxmd.com/read/27890727/synthetic-tambjamine-analogues-induce-mitochondrial-swelling-and-lysosomal-dysfunction-leading-to-autophagy-blockade-and-necrotic-cell-death-in-lung-cancer
#1
Ananda M Rodilla, Luís Korrodi-Gregório, Elsa Hernando, Pilar Manuel-Manresa, Roberto Quesada, Ricardo Pérez-Tomás, Vanessa Soto-Cerrato
Current pharmacological treatments for lung cancer show very poor clinical outcomes, therefore, the development of novel anticancer agents with innovative mechanisms of action is urgently needed. Cancer cells have a reversed pH gradient compared to normal cells, which favours cancer progression by promoting proliferation, metabolic adaptation and evasion of apoptosis. In this regard, the use of ionophores to modulate intracellular pH appears as a promising new therapeutic strategy. Indeed, there is a growing body of evidence supporting ionophores as novel antitumour drugs...
November 24, 2016: Biochemical Pharmacology
https://www.readbyqxmd.com/read/27855253/-musculoskeletal-disorders-and-temporary-disability-characteristics-and-duration-catalonia-2007-2010
#2
Ignasi Manent Bistué, José Mª Ramada Rodilla, Consol Serra Pujadas
BACKGROUND: Musculoskeletal disorders (MSD) are the leading cause of sickness absence (SA) in Spain and the second in Catalonia. A greater knowledge of this field could allow the refocusing of social protection policies and interventions to reduce their frequency and duration. The objective of the study was to describe the characteristics and duration of SA due to MSD in Catalonia between 2007 and 2010. METHODS: The study population included all incident SA episodes due to MSD during the period 2007-2010, registered in the Institut Català d'AvaluacionsMèdiques (ICAM) database...
October 2016: Archivos de Prevención de Riesgos Laborales
https://www.readbyqxmd.com/read/27835822/woven-coronary-artery-anomaly-presenting-as-sudden-cardiac-death
#3
José-Fernando Val-Bernal, Séfora Malaxetxebarria, Irene González-Rodilla, Miguel Salas-García
Woven coronary artery is a rare anomaly characterized by thin channels arising from the coronary artery and reanastomosing at the distal arterial segment. To our knowledge, no data are available currently on the histologic structure of the woven segment. A 39-year-old man presented with sudden atypical chest pain while he was practicing cycling. During the transfer of the patient to the hospital, he suffered cardiac arrest. After 50 min of cardiopulmonary resuscitation, the patient could not return to sinus rhythm and died...
October 20, 2016: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/27777848/antibacterial-and-antioxidant-activity-of-portuguese-lavandula-luisieri-rozeira-rivas-martinez-and-its-relation-with-their-chemical-composition
#4
Sofia Pombal, Cleide F Rodrigues, João P Araújo, Pedro M Rocha, Jesus M Rodilla, David Diez, Ángela P Granja, Arlindo C Gomes, Lúcia A Silva
Lavandula luisieri (Rozeira) Rivas-Martinez is an endemic aromatic Labiatae the Iberian Peninsula, common in semi-arid regions of southern Portugal and southwestern Spain, that produces an active antibacterial essential oil from the leaves and flowers. This work presents the study of the chemical variation in various stages of growth of leaves and flowers of L. luisieri. It has been found that the essential oils are mainly constituted by 1,8-cineol, camphor, linalool and trans-α-necrodil acetate. It was also studied the total phenol content and the antioxidant activity on leaves and flowers...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27754043/os-13-09-relationship-between-24-hour-ambulatory-central-blood-pressure-and-left-ventricular-mass-a-prospective-multicenter-study
#5
Thomas Weber, Siegfried Wassertheurer, Enrique Rodilla Sala, Cornelia Ablasser, Piotr Jankowski, Maria Lorenza Muisan, Cristina Giannatasio, Claudia Mang, Arno Schmidt-Trucksäss, Ian Wilkinson, Carmel McEniery
OBJECTIVE: To investigate the relationship between left ventricular mass (LVM) and brachial office systolic blood pressure (bOSBP), brachial 24 hours ambulatory SBP (bASBP) and central 24 hours ambulatory SBP (cASBP). DESIGN AND METHOD: In 7 European centers, bASBP was measured with a validated automated oscillometric device (mobilograph, i.e.m., Stolberg, Germany). cASBP was determined, using a transfer function, and mean/diastolic BP calibration. M-mode images were obtained by echocardiography, and LVM was determined by one single reader according to standard guidelines and normalized to body surface area...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27708571/error-related-negativity-and-the-misattribution-of-state-anxiety-following-errors-on-the-reproducibility-of-inzlicht-and-al-khindi
#6
Carmen Cano Rodilla, André Beauducel, Anja Leue
In their innovative study, Inzlicht and Al-Khindi (2012) demonstrated that participants who were allowed to misattribute their arousal and negative affect induced by errors to a placebo beverage had a reduced error-related negativity (ERN/Ne) compared to controls not being allowed to misattribute their arousal following errors. These results contribute to the ongoing debate that affect and motivation are interwoven with the cognitive processing of errors. Evidence that the misattribution of negative affect modulates the ERN/Ne is essential for understanding the mechanisms behind ERN/Ne...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27642963/os-13-09-relationship-between-24-hour-ambulatory-central-blood-pressure-and-left-ventricular-mass-a-prospective-multicenter-study
#7
Thomas Weber, Siegfried Wassertheurer, Enrique Rodilla Sala, Cornelia Ablasser, Piotr Jankowski, Maria Lorenza Muisan, Cristina Giannatasio, Claudia Mang, Arno Schmidt-Trucksäss, Ian Wilkinson, Carmel McEniery
OBJECTIVE: To investigate the relationship between left ventricular mass (LVM) and brachial office systolic blood pressure (bOSBP), brachial 24 hours ambulatory SBP (bASBP) and central 24 hours ambulatory SBP (cASBP). DESIGN AND METHOD: In 7 European centers, bASBP was measured with a validated automated oscillometric device (mobilograph, i.e.m., Stolberg, Germany). cASBP was determined, using a transfer function, and mean/diastolic BP calibration. M-mode images were obtained by echocardiography, and LVM was determined by one single reader according to standard guidelines and normalized to body surface area...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27575529/-arterial-hypertension-and-prediabetes
#8
Patricia Boned Ombuena, Enrique Rodilla Sala, José Antonio Costa Muñoz, José María Pascual Izuel
BACKGROUND AND OBJECTIVES: The aim of this study was to assess the factors related to new diabetes in hypertensive. PATIENTS AND METHODS: This prospective follow-up study involved 2588 non-diabetic, hypertensive patients. The total follow-up was 15053 patient-years with a median of 3.4 years (interquartile interval 1.4-6.8). RESULTS: During the follow-up 333 (13%) patients had new diabetes, with a conversion rate of 2.21 (95% confidence interval [CI], 1...
November 4, 2016: Medicina Clínica
https://www.readbyqxmd.com/read/27508788/-op-6c-06-fixed-dosed-combinations-of-arb-are-superior-to-extemporaneous-combinations-in-reducing-total-mortality-and-cardiovascular-morbidity
#9
E Rodilla Sala, R Maroto, F Lobo, J M Pascual
OBJECTIVE: Control of HTN remains unsatisfactory in the majority of hypertensive patients, even after introduction of multidrug therapeutic strategies. Newly developed treatments based on fixed-dosed combinations (FDC) of complementary drugs are said to improve control. This study aims to compare the efficacy of FDC versus extemporaneous combinations on total mortality and cardiovascular morbidity in a real-life setting. DESIGN AND METHOD: Post-observational, descriptive, longitudinal, retrospective study in Primary Care of the Valencian Community, including 181...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27435956/muckle-wells-syndrome-a-case-report-with-an-nlrp3-t348m-mutation
#10
Elena Naz Villalba, Enrique Gomez de la Fuente, Dolores Caro Gutierrez, Fernando Pinedo Moraleda, Julio Yanguela Rodilla, Diana Mazagatos Angulo, Jose Luis López Estebaranz
Autoinflammatory syndromes are a recently described group of conditions caused by mutations in multiple genes that code for proteins of the innate immune system. Cryopyrin-associated periodic syndromes are autoinflammatory diseases comprising three clinically overlapping disorders: familial cold urticaria syndrome, Muckle-Wells syndrome (MWS), and neonatal-onset multisystem inflammatory disease. MWS is characterized by a moderate phenotype with fever, rash, arthralgia, conjunctivitis, sensorineural deafness, and potentially life-threatening amyloidosis...
September 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27399222/predictive-capacity-of-cloninger-s-temperament-and-character-inventory-tci-r-in-alcohol-use-disorder-outcomes
#11
José Juan Ávila Escribano, Mercedes Sánchez Barba, Aida Álvarez Pedrero, Ana López Villarreal, Joaquina Recio Pérez, Manuela Rodríguez Rodilla, Eulalia Fraile García
OBJECTIVE: to investigate the ability to predict the outcome of alcohol use disorders through Cloninger's temperament and character inventory (TCI-R). METHODS: this is a prospective study consisting of 237 outpatients with alcohol use disorders who underwent follow-up treatment for 6 months and whose personality traits were studied using TCI-R. At the end of that period, the scores of each TCI-R trait were analyzed in terms of those who remained in treatment and those who dropped out...
2016: Adicciones
https://www.readbyqxmd.com/read/27376533/effects-of-improved-fat-meat-products-consumption-on-emergent-cardiovascular-disease-markers-of-male-volunteers-at-cardiovascular-risk
#12
Paloma Celada, Francisco J Sánchez-Muniz, Gonzalo Delgado-Pando, Sara Bastida, Manuel Espárrago Rodilla, Francisco Jiménez-Colmenero, Begoña Olmedilla-Alonso
High meat-product consumption has been related to cardiovascular disease (CVD). However, previous results suggest the benefits of consuming improved fat meat products on lipoprotein-cholesterol and anthropometric measurements. Present study aims to assess the effect of consuming different Pâté and Frankfurter formulations on emergent CVD biomarkers in male volunteers at increased CVD risk. Eighteen male volunteers with at least two CVD risk factors were enrolled in a sequentially controlled study where different pork-products were tested: reduced-fat (RF), omega-3-enriched-RF (n-3RF), and normal-fat (NF)...
December 2016: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/27326981/clinical-practice-guidelines-for-diagnosis-and-management-of-hypersensitivity-reactions-to-contrast-media
#13
REVIEW
A Rosado Ingelmo, I Doña Diaz, R Cabañas Moreno, M C Moya Quesada, C García-Avilés, I García Nuñez, J I Martínez Tadeo, R Mielgo Ballesteros, N Ortega-Rodríguez, M A Padial Vilchez, L Sánchez-Morillas, C Vila Albelda, E Moreno Rodilla, M J Torres Jaén
The objective of these guidelines is to ensure efficient and effective clinical practice. The panel of experts who produced this consensus document developed a research protocol based on a review of the literature. The prevalence of allergic reactions to iodinated contrast media (ICM) is estimated to be 1:170 000, that is, 0.05%-0.1% of patients undergoing radiologic studies with ICM (more than 75 million examinations per year worldwide). Hypersensitivity reactions can appear within the first hour after administration (immediate reactions) or from more than 1 hour to several days after administration (nonimmediate or delayed reactions)...
2016: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/27307493/efficient-nuclear-export-of-p65-i%C3%AE%C2%BAb%C3%AE-complexes-requires-14-3-3-proteins
#14
Cristina Aguilera, Vanessa Fernández-Majada, Julia Inglés-Esteve, Verónica Rodilla, Anna Bigas, Lluís Espinosa
No abstract text is available yet for this article.
June 15, 2016: Journal of Cell Science
https://www.readbyqxmd.com/read/27069176/magnetic-resonance-imaging-for-the-pre-surgical-assessment-of-endometrial-cancer-results-in-a-routine-clinical-setting-outside-dedicated-trials-a-cross-sectional-study
#15
Javier Arnaiz, Ana-Belen Muñoz, Virginia Verna, Irene Gonzalez-Rodilla, Jose Schneider
AIM: To assess the efficacy of magnetic resonance imaging (MRI) in predicting the surgical stage of endometrial carcinoma as a diagnostic tool, in a routine clinical setting, and not just in dedicated pilot studies or trials. MATERIALS AND METHODS: The stage prediction made on MRI, as stated in the Radiology report, was compared with the effective surgical stage registered in the Pathology report. The 2009 International Federation of Gynecology and Obstetrics (FIGO) staging was used...
April 2016: Anticancer Research
https://www.readbyqxmd.com/read/26913544/iodine-a-mild-reagent-for-the-aromatization-of-terpenoids
#16
Victoriano Domingo, Consuelo Prieto, Lucia Silva, Jesús M L Rodilla, José F Quílez del Moral, Alejandro F Barrero
Efficient procedures based on the use of iodine for the aromatization of a series of terpenoids possessing diene and homoallylic or allylic alcohol functionalities are described. Different examples are reported as a proof-of-concept study. Furthermore, iodine also proved to mediate the dehydrogenation of testosterone.
April 22, 2016: Journal of Natural Products
https://www.readbyqxmd.com/read/26798828/terahertz-radiation-induces-non-thermal-structural-changes-associated-with-fr%C3%A3-hlich-condensation-in-a-protein-crystal
#17
Ida V Lundholm, Helena Rodilla, Weixiao Y Wahlgren, Annette Duelli, Gleb Bourenkov, Josip Vukusic, Ran Friedman, Jan Stake, Thomas Schneider, Gergely Katona
Whether long-range quantum coherent states could exist in biological systems, and beyond low-temperature regimes where quantum physics is known to be applicable, has been the subject to debate for decades. It was proposed by Fröhlich that vibrational modes within protein molecules can order and condense into a lowest-frequency vibrational mode in a process similar to Bose-Einstein condensation, and thus that macroscopic coherence could potentially be observed in biological systems. Despite the prediction of these so-called Fröhlich condensates almost five decades ago, experimental evidence thereof has been lacking...
September 2015: Structural Dynamics (Melville, N.Y.)
https://www.readbyqxmd.com/read/26786983/millimeter-wave-sensor-based-on-a-%C3%AE-2-line-resonator-for-identification-and-dielectric-characterization-of-non-ionic-surfactants
#18
H Rodilla, A A Kim, G D M Jeffries, J Vukusic, A Jesorka, J Stake
Studies of biological and artificial membrane systems, such as niosomes, currently rely on the use of fluorescent tags, which can influence the system under investigation. For this reason, the development of label-free, non-invasive detection techniques is of great interest. We demonstrate an open-volume label-free millimeter-wave sensing platform based on a coplanar waveguide, developed for identification and characterization of niosome constituents. A design based on a λ/2-line resonator was used and on-wafer measurements of transmission and reflection parameters were performed up to 110 GHz...
2016: Scientific Reports
https://www.readbyqxmd.com/read/26637281/impaired-prc2-activity-promotes-transcriptional-instability-and-favors-breast-tumorigenesis
#19
Michel Wassef, Veronica Rodilla, Aurélie Teissandier, Bruno Zeitouni, Nadege Gruel, Benjamin Sadacca, Marie Irondelle, Margaux Charruel, Bertrand Ducos, Audrey Michaud, Matthieu Caron, Elisabetta Marangoni, Philippe Chavrier, Christophe Le Tourneau, Maud Kamal, Eric Pasmant, Michel Vidaud, Nicolas Servant, Fabien Reyal, Dider Meseure, Anne Vincent-Salomon, Silvia Fre, Raphaël Margueron
Alterations of chromatin modifiers are frequent in cancer, but their functional consequences often remain unclear. Focusing on the Polycomb protein EZH2 that deposits the H3K27me3 (trimethylation of Lys27 of histone H3) mark, we showed that its high expression in solid tumors is a consequence, not a cause, of tumorigenesis. In mouse and human models, EZH2 is dispensable for prostate cancer development and restrains breast tumorigenesis. High EZH2 expression in tumors results from a tight coupling to proliferation to ensure H3K27me3 homeostasis...
December 15, 2015: Genes & Development
https://www.readbyqxmd.com/read/26632983/facilitated-anion-transport-induces-hyperpolarization-of-the-cell-membrane-that-triggers-differentiation-and-cell-death-in-cancer-stem-cells
#20
Vanessa Soto-Cerrato, Pilar Manuel-Manresa, Elsa Hernando, Silvia Calabuig-Fariñas, Alicia Martínez-Romero, Víctor Fernández-Dueñas, Kristoffer Sahlholm, Thomas Knöpfel, María García-Valverde, Ananda M Rodilla, Eloisa Jantus-Lewintre, Rosa Farràs, Francisco Ciruela, Ricardo Pérez-Tomás, Roberto Quesada
Facilitated anion transport potentially represents a powerful tool to modulate various cellular functions. However, research into the biological effects of small molecule anionophores is still at an early stage. Here we have used two potent anionophore molecules inspired in the structure of marine metabolites tambjamines to gain insight into the effect induced by these compounds at the cellular level. We show how active anionophores, capable of facilitating the transmembrane transport of chloride and bicarbonate in model phospholipid liposomes, induce acidification of the cytosol and hyperpolarization of plasma cell membranes...
December 23, 2015: Journal of the American Chemical Society
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