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https://www.readbyqxmd.com/read/29665393/comparative-experimental-theoretical-studies-on-the-egfr-dimerization-under-the-effect-of-egf-egf-analogues-binding-highlighting-the-importance-of-egf-egfr-interactions-at-site-iii-interface
#1
Masomeh Mehrabi, Hamid Mahdiuni, Hassan Rasouli, Kamran Mansouri, Mohsen Shahlaie, Reza Khodarahmi
Epidermal growth factor receptors (EGFRs) and their cytoplasmic tyrosine kinases play significant roles in cell proliferation and signaling. All the members of the EGFR/ErbB family are primary goals for cancer therapy, particularly for tumors of breast, cervix, ovaries, kidney, esophagus, prostate and non-small-cell lung carcinoma and head and neck tumors. However, the therapeutic ability of accessible anti-ErbB agents is limited. Therefore, recognizing EGF analogues or small organic molecules with high affinity for the extracellular domain of the EGFR is a critical target on cancer research...
April 14, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29651565/synthesis-and-preclinical-evaluation-of-novel-18-f-labeled-glu-urea-glu-based-psma-inhibitors-for-prostate-cancer-imaging-a-comparison-with-18-f-dcfpyl-and-18-f-psma-1007
#2
Stephanie Robu, Alexander Schmidt, Matthias Eiber, Margret Schottelius, Thomas Günther, Behrooz Hooshyar Yousefi, Markus Schwaiger, Hans-Jürgen Wester
BACKGROUND: Due to its high and consistent expression in prostate cancer (PCa), the prostate-specific membrane antigen (PSMA) represents an ideal target for molecular imaging and targeted therapy using highly specific radiolabeled PSMA ligands. To address the continuously growing clinical demand for 18 F-labeled PSMA-probes, we developed two novel Glu-urea-Glu-(EuE)-based inhibitors, EuE-k-18 F-FBOA (1) and EuE-k-β-a-18 F-FPyl (2), both with optimized linker structure and different 18 F-labeled aromatic moieties...
April 12, 2018: EJNMMI Research
https://www.readbyqxmd.com/read/29626242/incidence-of-kidney-stone-disease-in-icelandic-children-and-adolescents-from-1985-to-2013-results-of-a-nationwide-study
#3
Vidar O Edvardsson, Solborg E Ingvarsdottir, Runolfur Palsson, Olafur S Indridason
BACKGROUND: An increase in the incidence of kidney stone disease has been reported for all age groups worldwide. To examine this trend, we conducted a nationwide study of the epidemiology of kidney stones in Icelandic children and adolescents over a 30-year period. METHODS: Computerized databases of all major hospitals and medical imaging centers in Iceland were searched for International Classification of Diseases and radiologic and surgical procedure codes indicative of kidney stones in patients aged < 18 years, followed by a thorough medical record review...
April 6, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29596317/distribution-of-glutathione-stabilized-gold-nanoparticles-in-feline-fibrosarcomas-and-their-role-as-a-drug-delivery-system-for-doxorubicin-preclinical-studies-in-a-murine-model
#4
Katarzyna Zabielska-Koczywąs, Anna Wojtalewicz, Ewelina Użarowska, Agata Klejman, Agata Wojtkowska, Izabella Dolka, Marek Wojnicki, Katarzyna Sobczak, Michał Wójcik, Haifa Shen, Mauro Ferrari, Roman Lechowski
Feline injection site sarcomas (FISS) are malignant skin tumors with high recurrence rates despite the primary treatment of radical surgical resections. Adjunctive radiotherapy or chemotherapy with doxorubicin is mostly ineffective. Cellular and molecular causes of multidrug resistance, specific physio-chemical properties of solid tumors impairing drug transport, and the tumor microenvironment have been indicated for causing standard chemotherapy failure. Gold nanoparticles are promising imaging tools, nanotherapeutics, and drug delivery systems (DDS) for chemotherapeutics, improving drug transport within solid tumors...
March 29, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29571154/postmortem-interval-estimation-using-the-animal-model-of-postmortem-gas-volume-changes
#5
Chika Iwamoto, Kenoki Ohuchida, Miki Okumura, Yosuke Usumoto, Junji Kishimoto, Masaharu Murata, Noriaki Ikeda, Makoto Hashizume
It is important to estimate the postmortem interval in forensic autopsy. Many methods to estimate the postmortem interval have been reported, and are typically associated with internal examination. However, there are issues such as rejection of autopsy by the family and a lack of forensic doctor in internal examination. Therefore, it is necessary to develop new methods, such as autopsy imaging, that can substitute for internal examination. Here, we first evaluated whether gas volume in the body increased with postmortem interval...
December 20, 2017: Legal Medicine
https://www.readbyqxmd.com/read/29542819/nephroblastoma-in-bester-sturgeon-a-cultured-hybrid-of-huso-huso-%C3%A3-acipenser-ruthenus-diagnostic-imaging-clinical-and-histopathological-study
#6
H Rahmati-Holasoo, M Soltani, M Masoudifard, S Shokrpoor, A Taheri Mirghaed, M Ahmadpoor
Abdominal distention occurred at an incidence of 1% (15 from 1500 fish) in the population of 1-year-old bester (Huso huso × Acipenser ruthenus). Computed tomography (CT) images and radiographs showed a soft tissue mass compressed the posterior part of the swim bladder. Ultrasonography showed that the masses had different patterns. Internal examination revealed the abdominal cavities to be filled with large masses which appeared to encompass most of the visceral organs, including the swim bladder. The masses originated from the posterior kidney...
March 15, 2018: Journal of Fish Diseases
https://www.readbyqxmd.com/read/29534686/unexpected-presentation-of-allograft-dysfunction-triggered-by-page-kidney-phenomenon-immediately-after-kidney-transplantation-a-case-report
#7
Shunta Hori, Mitsuru Tomizawa, Fumisato Maesaka, Takuya Owari, Yosuke Morizawa, Yasushi Nakai, Makito Miyake, Tatsuo Yoneda, Nobumichi Tanaka, Katsunori Yoshida, Kiyohide Fujimoto
BACKGROUND: Page kidney phenomenon is caused by strong renal parenchymal compression and leads to renal hypoperfusion and microvascular ischemia, resulting in renal dysfunction and hypertension. Although the development of Page kidney phenomenon in allograft is rare, most of its cases are induced by allograft biopsy or trauma. We observed a case of Page kidney phenomenon that was induced by unusual causes immediately after kidney transplantation. CASE PRESENTATION: A 66-year-old man, whose wife donated a kidney, underwent ABO-compatible living kidney transplantation...
March 13, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29499713/efficient-targeted-tumor-imaging-and-secreted-endostatin-gene-delivery-by-anti-cd105-immunoliposomes
#8
Huiqin Zhuo, Baoshi Zheng, Jianming Liu, Yong Huang, Huiling Wang, Duo Zheng, Naiquan Mao, Jinyu Meng, Sufang Zhou, Liping Zhong, Yongxiang Zhao
BACKGROUND: Anti-CD105 mAb-conjugated immunoliposomes, loaded with secreted mouse endostatin gene, were developed for targeted tumor imaging and antiangiogenic gene therapy. METHODS: The liposomes were investigated for size, zeta-potential, lipid content, antibody binding ability, and pcDNA loading capacity. The ability of immunoliposomes to target tumor-derived endothelial cells and perform gene transfer in vitro was measured and their basic biocompatibility was evaluated...
March 2, 2018: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/29477809/pictorial-review-renal-ultrasound
#9
REVIEW
Mittul Gulati, Justin Cheng, Jerry T Loo, Matt Skalski, Harshawn Malhi, Vinay Duddalwar
Ultrasound (US) is the first-line imaging modality for evaluating azotemic patients for urinary obstruction and renal size. US is also valuable for distinguishing congenital variants and simple cystic lesions from renal masses. Doppler US is effective in detection of renal calculi and evaluation of vascular pathology. Unfortunately, renal US is limited in distinguishing causes of medical renal disease. The kidneys have a complex internal architecture with a highly variable appearance on US. This article illustrates non-neoplastic renal conditions, including normal and embryological variants, parenchymal, cystic, and vascular diseases...
February 16, 2018: Clinical Imaging
https://www.readbyqxmd.com/read/29470042/fabrication-of-charge-conversion-nanoparticles-for-cancer-imaging-by-flash-nanoprecipitation
#10
Meng Li, Yisheng Xu, Jinli Sun, Mingwei Wang, Dahai Yang, Xuhong Guo, Haiyun Song, Song Cao, Yunfeng Yan
Traditional charge-conversion nanoparticles (NPs) need the breakage of acid-labile groups on the surface which impedes the rapid response to the acidic microenvironment. Here, we developed novel rod-like charge-conversion NPs with amphiphilic Dex-b-PLGA, PDMAEMA-b-PCL, and an AIE-active probe through Flash Nanoprecipitation (FNP). These NPs exhibit reversible negative-to-positive charge transition at slightly acidic pH relying on the rapid protonation/deprotonation of polymers. The size and the critical charge-conversion pH can be further tuned by varying the flow rate and polymer ratio...
February 22, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29423350/primary-psychiatric-disorder-masking-the-diagnosis-of-neuropsychiatric-lupus-in-a-patient-with-altered-mental-status-a-case-report
#11
Osman Perez, Kairavee Dave, Aimee Almanzar, Tajul Prodhan, Livasky Concepion
Neuropsychiatric systemic lupus erythematosus (NPSLE) has a wide variety of neurologic and psychiatric features. NPSLE symptoms and the psychotic features of primary psychiatric disorders often overlap with each other. These psychotic features often mask and delay the diagnosis of NPSLE. We present the case of a 59-year-old female previously diagnosed with bipolar disorder and generalized anxiety disorder presenting with altered mental status (AMS), subsequently diagnosed with neuropsychiatric lupus. Initially, medication overdose was suspected as an empty bottle of trazodone was found beside her...
October 23, 2017: Curēus
https://www.readbyqxmd.com/read/29412638/reduced-18f-folate-conjugates-as-a-new-class-of-pet-tracers-for-folate-receptor-imaging
#12
Silvan D Boss, Cristina Müller, Klaudia Siwowska, Josephine Büchel, Rafaella Schmid, Viola Groehn, Roger Schibli, Simon Mensah Ametamey
5-Methyltetrahydrofolate (5-MTHF), a reduced folate form, is the biologically active folate involved in many different metabolic processes. To date, there are no studies available in the literature on 18F-labeled 6S- and 6R-5-MTHF radiotracers for imaging FR-α-positive tissues. Therefore, the goal of this study was to synthesize four 18F-labeled 5-MTHF derivatives conjugated at either the α- or γ-carboxylic functionality of glutamate and to assess their suitability for folate receptor (FR)-targeting. Organic syntheses of the precursors and the four reference compounds, namely 6S-α, 6S-γ, 6R-α and 6R-γ-click-fluoroethyl-5-MTHF, were carried out in low to moderate overall chemical yields...
February 7, 2018: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29400475/albumin-binding-psma-ligands-optimization-of-the-tissue-distribution-profile
#13
Martina Benešová, Christoph A Umbricht, Roger Schibli, Cristina Müller
The prostate-specific membrane antigen (PSMA) has emerged as an attractive prostate cancer associated target for radiotheragnostic application using PSMA-specific radioligands. The aim of this study was to design new PSMA ligands modified with an albumin-binding moiety in order to optimize their tissue distribution profile. The compounds were prepared by conjugation of a urea-based PSMA-binding entity, a DOTA chelator, and 4-(p-iodophenyl)butyric acid using multistep solid phase synthesis. The three ligands (PSMA-ALB-02, PSMA-ALB-05, and PSMA-ALB-07) were designed with varying linker entities...
February 5, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29390277/a-rare-case-report-of-bilateral-common-and-internal-iliac-arterial-fibromuscular-dysplasia-coexisted-dissection-aneurysm-and-stenosis
#14
Luyun Fan, Wenjun Ma, Huimin Zhang, Jun Cai
RATIONALE: Iliac arterial fibromuscular dysplasia (FMD) was rarely reported and its demographic, clinical, and imaging features have not been precisely described resulting in uncertain therapeutic methods. PATIENT CONCERNS: A 31-year-old man was referred because of 3-month-ago onset hypertension, low serum potassium, and a small-sized right kidney with normal renal artery under ultrasound examination. This patient was suspected of primary aldosteronism, whereas spirolactone was poorly effective...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29380423/improved-tolerance-to-off-resonance-in-spectral-spatial-epi-of-hyperpolarized-1-13-c-pyruvate-and-metabolites
#15
Justin Y C Lau, Benjamin J Geraghty, Albert P Chen, Charles H Cunningham
PURPOSE: For 13 C echo-planar imaging (EPI) with spectral-spatial excitation, main field inhomogeneity can result in reduced flip angle and spatial artifacts. A hybrid time-resolved pulse sequence, multi-echo spectral-spatial EPI, is proposed combining broader spectral-spatial passbands for greater off-resonance tolerance with a multi-echo acquisition to separate signals from potentially co-excited resonances. METHODS: The performance of the imaging sequence and the reconstruction pipeline were evaluated for 1 H imaging using a series of increasingly dilute 1,4-dioxane solutions and for 13 C imaging using an ethylene glycol phantom...
January 29, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29367095/re-co-3-18-f-feda-a-novel-18-f-pet-renal-tracer-radiosynthesis-and-preclinical-evaluation
#16
Malgorzata Lipowska, Nashwa Jarkas, Ronald J Voll, Jonathon A Nye, Jeffrey Klenc, Mark M Goodman, Andrew T Taylor
INTRODUCTION: Our previous work demonstrated that the 99m Tc renal tracer, 99m Tc(CO)3 (FEDA) (99m Tc-1), has a rapid clearance comparable in rats to that of 131 I-OIH, the radioactive gold standard for the measurement of effective renal plasma flow. The uncharged fluoroethyl pendant group of 99m Tc-1 provides a route to the synthesis of a structurally analogous rhenium-tricarbonyl 18 F renal imaging agent, Re(CO)3 ([18 F]FEDA) (18 F-1). Our goal was to develop an efficient one-step method for the preparation of 18 F-1 and to compare its pharmacokinetic properties with those of 131 I-OIH in rats...
March 2018: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/29354336/severe-hypoglycemia-induced-right-hemiparesis-with-reversible-diffusion-restriction-in-the-left-internal-capsule-due-to-combination-therapy-using-disopyramide-and-clarithromycin
#17
Yoshito Sugita, Masaomi Koyanagi, Masashi Oda, Tamaki Kobayashi, Osamu Narumi, Masaaki Saiki
Severe hypoglycemia is known to cause acute focal neurological symptoms. In cases with a medical history of diabetes mellitus (DM), the diagnosis and treatment of hypoglycemia-induced neurological symptoms are simple. However, severe hypoglycemia can occur in patients who are not taking hypoglycemic agents such as insulin or long-acting sulfonylurea drugs. We describe a 95-year-old man with sudden onset of right hemiparesis who showed high signal intensity on diffusion-weighted imaging involving the left internal capsule with corresponding reduced apparent diffusion coefficient hypointensity...
January 2018: NMC Case Report Journal
https://www.readbyqxmd.com/read/29348825/a-novel-anti-cd146-antibody-specifically-targets-cancer-cells-by-internalizing-the-molecule
#18
Marie Nollet, Jimmy Stalin, Anaïs Moyon, Waël Traboulsi, Amel Essaadi, Stéphane Robert, Nausicaa Malissen, Richard Bachelier, Laurent Daniel, Alexandrine Foucault-Bertaud, Caroline Gaudy-Marqueste, Romaric Lacroix, Aurélie S Leroyer, Benjamin Guillet, Nathalie Bardin, Françoise Dignat-George, Marcel Blot-Chabaud
CD146 is an adhesion molecule present on many tumors (melanoma, kidney, pancreas, breast, ...). In addition, it has been shown to be expressed on vascular endothelial and smooth muscle cells. Generating an antibody able to specifically recognize CD146 in cancer cells (designated as tumor CD146), but not in normal cells, would thus be of major interest for targeting tumor CD146 without affecting the vascular system. We thus generated antibodies against the extracellular domain of the molecule produced in cancer cells and selected an antibody that specifically recognizes tumor CD146...
December 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29325693/updates-in-the-eighth-edition-of-the-tumor-node-metastasis-staging-classification-for-urologic-cancers
#19
REVIEW
Gladell P Paner, Walter M Stadler, Donna E Hansel, Rodolfo Montironi, Daniel W Lin, Mahul B Amin
The Tumor-Node-Metastasis (TNM) classification on cancer staging, jointly developed by the American Joint Commission on Cancer (AJCC) and the Union for International Cancer Control (UICC), has been updated to its 8th edition with two contemporaneous versions published by the AJCC and UICC. While the goal of the AJCC and UICC is to have identical TNM staging systems, differences exist between these two publications including in the staging of urologic cancers. Among several new facets in the AJCC staging manual, a select few of greater import include an expanded section on imaging, presentation of levels of evidence for significant changes, and endorsement of risk assessment models that pass the AJCC quality criteria such as in prostate cancer...
April 2018: European Urology
https://www.readbyqxmd.com/read/29324912/diuresis-renography-and-ultrasonography-in-children-with-antenatally-detected-hydronephrosis-can-support-diagnoses-and-suggest-related-surgery-treatment
#20
M Radulović, S Beatović, M Janković, Dragana Šobić-Šaranović, Vera Artiko, Boris Ajdinović
OBJECTIVE: Prenatal ultrasound (US) screening detects the hydronephrosis (HN)-dilatation of fetal renal collecting system in 1%-5% of all pregnancies. In most children, HN is detected by prenatal US screening between 18-20 gestational week. Pelvi- ureteric junction (PUJ) stenosis is the most common etiological factor of prenatal HN and requires postnatal follow-up. Diuresis renography plays important role in the follow-up by complementing morphological information obtained by US with the data about differential renal function (DRF) and drainage...
September 2017: Hellenic Journal of Nuclear Medicine
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