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https://www.readbyqxmd.com/read/29156817/near-infrared-photothermal-therapy-using-anti-egfr-gold-nanorod-conjugates-for-triple-negative-breast-cancer
#1
Meihua Zhang, Hoe Suk Kim, Tiefeng Jin, Jisu Woo, Yin Ji Piao, Woo Kyung Moon
Current EGFR-targeted therapy for triple negative breast cancer (TNBC) has produced disappointing results. A rational therapeutic strategy to improve EGFR-targeted treatment for TNBC is therefore needed. In this study we evaluated the feasibility of treating TNBC using photoacoustic imaging (PAI)-guided near-infrared photothermal therapy (NIR-PTT) with anti-EGFR-conjugated gold nanorods (anti-EGFR-GN). NIR-PTT combined with anti-EGFR-GN exerted synergistic anti-proliferative and apoptotic actions through upregulation of HSP70 and cleaved caspase-3, downregulation of Ki-67 and EGFR, and inhibition of several intracellular signaling molecules (mTOR, AKT, ERK1/2 and FAK)...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29154224/evaluation-of-whole-pork-belly-qualitative-and-quantitative-properties-using-selective-belly-muscle-parameters
#2
Eun-A Lee, Ji-Hoon Kang, Jin-Hyung Cheong, Kyung-Chul Koh, Woo-Min Jeon, Jee-Hwan Choe, Ki-Chang Hong, Jun-Mo Kim
The objective of this study was to identify parameters for the evaluation of pork belly quality (composition) and quantity (volume) and to develop regression equations that predict properties of whole pork belly. Through an image analysis of 648 bellies, newly characterized pork belly parameters were developed for evaluating pork belly quality and quantity. Importantly, the estimated muscle volume showed high positive correlation with the whole belly volume and the whole belly muscle percentage (r=0.458, and 0...
November 10, 2017: Meat Science
https://www.readbyqxmd.com/read/29151288/-the-value-of-18-f-fdg-pet-ct-imaging-in-predicting-the-malignant-potential-of-gist
#3
S X Li, M D Tang, D Y Lin, D J Liu, Q H Lyu, J P Zhang, Z H Cai
Objective: To evaluate the value of (18)F-FDG PET-CT in predicting the malignant potential of Gastrointestinal Stromal Tumors (GIST). Methods: The clinical and pathological features of 31 patients with GIST confirmed by surgery or biopsy were retrospectively analyzed. The malignant potential of GIST before treatment was assessed by (18)F-FDG PET-CT. The GIST risk classification was graded according to the Standard revised by the National Institutes of Health (NIH) in 2008. The relationship between the maximal standard uptake value (SUVmax) and GIST risk classification, tumor diameter, Ki-67 index, and mitotic count were analyzed respectively...
November 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/29146671/predictors-and-long-term-clinical-outcome-of-longitudinal-stent-deformation-insights-from-pooled-analysis-of-korean-multicenter-drug-eluting-stent-cohort
#4
Tae-Min Rhee, Kyung Woo Park, Joo Myung Lee, Michael S Lee, Ki-Hyun Jeon, Hyun-Jae Kang, Bon-Kwon Koo, Jay Young Rhew, Kwang Soo Cha, Jang-Ho Bae, Kyoo-Rok Han, Si-Hoon Park, Woo-Jung Park, Seung-Woon Rha, Seok-Kyu Oh, Hyuck Moon Kwon, Ki-Bae Seung, Taehoon Ahn, Sang-Hyun Kim, Hyo-Soo Kim
BACKGROUND: There are limited data on the frequency of and factors associated with quantitative coronary angiography (QCA)-defined longitudinal stent deformation (LSD) in various contemporary drug-eluting stents platforms. This study sought to evaluate the predictors of LSD and its long-term clinical implication. METHODS AND RESULTS: A patient-level pooled analysis was performed with 7350 lesions in 5871 patients treated with platinum-chromium-based everolimus-eluting stent (Promus Element), cobalt-chromium-based everolimus-eluting stent (Promus/Xience V), or cobalt-chromium-based zotarolimus-eluting stent (Endeavor Resolute)...
November 2017: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29144790/evaluation-of-ki-67-index-in-core-needle-biopsies-and-matched-breast-cancer-surgical-specimens
#5
Soomin Ahn, Junghye Lee, Min-Sun Cho, Sanghui Park, Sun Hee Sung
CONTEXT: - The Ki-67 index is strongly prognostic and is used as a surrogate marker to distinguish luminal A from luminal B breast cancer types. OBJECTIVE: - To investigate differences in Ki-67 index between core needle biopsy samples and matched surgical samples in breast cancer. DESIGN: - We included patients with invasive breast cancer who did not receive neoadjuvant therapy. A total of 89 pairs of core needle biopsies and surgical specimens were collected, and the Ki-67 index was assessed in hot spot areas using an image analyzer...
November 16, 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29143105/application-of-dwibs-in-malignant-lymphoma-correlation-between-adc-values-and-ki-67-index
#6
Mengtian Sun, Jingliang Cheng, Yong Zhang, Jie Bai, Feifei Wang, Yun Meng, Zhenqian Li
OBJECTIVES: We investigated the correlation between the apparent diffusion coefficient (ADC) and Ki-67 index using diffusion-weighted whole-body imaging with background body signal suppression (DWIBS), and their utility in evaluating malignant lymphoma cell proliferation. MATERIALS AND METHODS: Seventy-four patients with malignant lymphoma underwent DWIBS within 1 week before pathological confirmation. The ADC value was measured at the site of the pathological examination, and specimens were also stained with Ki-67...
November 15, 2017: European Radiology
https://www.readbyqxmd.com/read/29141018/evaluation-of-the-proliferation-marker-ki-67-in-a-large-prostatectomy-cohort
#7
Elin Richardsen, Sigve Andersen, Samer Al-Saad, Mehrdad Rakaee, Yngve Nordby, Mona Irene Pedersen, Nora Ness, Thea Grindstad, Ingeborg Movik, Tom Dønnem, Roy Bremnes, Lill-Tove Busund
The tumor proliferation index marker Ki-67 is strongly associated with tumor cell proliferation, growth and progression, and is widely used in routine clinicopathological investigation. Prostate cancer is a complex multifaceted and biologically heterogeneous disease, and overtreatment of localized, low volume indolent tumors, is evident. Here, we aimed to assess Ki-67 expression and related outcomes of 535 patients treated with radical prostatectomy. The percentage of tumor epithelial cells expressing Ki-67 was determined by immunohistochemical assay, both digital image analysis and visual scoring by light microscope were used for quantification...
2017: PloS One
https://www.readbyqxmd.com/read/29140676/synthesis-of-large-area-tungsten-disulfide-films-on-pre-reduced-tungsten-suboxides-substrates
#8
Soo Ho Choi, Stephen Boandoh, Young Ho Lee, Joo Song Lee, Ji-Hoon Park, Soo Min Kim, Woochul Yang, Ki Kang Kim
We report a facile method for the synthesis of large-area tungsten disulfide (WS2) film by means of chemical vapor deposition (CVD). To promote WS2 film growth, the precursor solution, which includes pre-reduced tungsten suboxides, is prepared by using hydrazine as the strong reduction agent and spin-coated onto the growth substrate. Growth is then carried out in a CVD chamber vaporized with dimethyl disulfide (DMDS) as the sulfur precursor. While only WS2 flakes are grown with un-reduced tungsten precursor under hydrogen atmosphere, WS2 film is readily attained on pre-reduced tungsten suboxide substrates without the need for further reduction by hydrogen, which is noted to induce discontinuity of grown film...
November 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29134518/erector-spinae-plane-block-for-the-management-of-chronic-shoulder-pain-a-case-report
#9
Mauricio Forero, Manikandan Rajarathinam, Sanjib Das Adhikary, Ki Jinn Chin
PURPOSE: The erector spinae plane (ESP) block has been described in the successful management of both thoracic and abdominal pain. Since the erector spinae muscle extends to the cervical spine, the ESP block may be potentially useful in painful conditions of the shoulder girdle. CLINICAL FEATURES: We performed a series of ESP blocks at the T2/T3 level in an elderly male patient with chronic shoulder pain. Immediate and profound analgesia with improved range of motion was consistently observed following the block...
November 13, 2017: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/29131458/image-analysis-is-an-excellent-tool-for-quantifying-ki-67-to-predict-the-prognosis-of-gastrointestinal-stromal-tumor-patients
#10
Shintaro Sugita, Hiroshi Hirano, Yutaka Hatanaka, Hiromi Fujita, Terufumi Kubo, Noriaki Kikuchi, Yumika Ito, Taro Sugawara, Keiko Segawa, Hiroyuki Hisai, Kentaro Yamashita, Takayuki Nobuoka, Yoshihiro Matsuno, Tadashi Hasegawa
We investigated the quantification of Ki-67 staining using digital image analysis (IA) as a complementary prognostic factor to the modified National Institutes of Health (NIH) classification in patients with gastrointestinal stromal tumor (GIST). We examined 92 patients, focusing on the correlation between age, sex, primary tumor site, tumor size, predominant histologic type, mitotic index, modified NIH classification (low/intermediate vs high), Ki-67 quantitation, and recurrence-free survival (RFS). We compared two IA processes for whole slide imaging (WSI) and manually captured image (MCI) methods...
November 13, 2017: Pathology International
https://www.readbyqxmd.com/read/29128375/is-the-pectoralis-major-tendon-a-reliable-reference-for-restoration-of-humeral-length-with-fracture-hemiarthroplasty
#11
Beom-Soo Kim, Du-Han Kim, Kwang-Soon Song, Byung-Woo Min, Ki-Cheor Bae, Chul-Hyun Cho
BACKGROUND: The primary objective was to calculate and to apply the numeric value of the distance from the pectoralis major tendon insertion to the superior aspect of the humeral head (PMTD) without any radiation exposure or equipment through basic data such as age, sex, height, and weight of Asian populations. METHODS: We analyzed shoulder magnetic resonance images of 260 patients (107 men and 153 women; average age, 59.8 years). The superior border of the pectoralis major was identified on the transverse section and cross-referenced with the coronal section...
November 8, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29126730/optimization-of-pharmacokinetic-properties-by-modification-of-a-carbazole-based-cannabinoid-receptor-subtype-2-cb2-ligand
#12
Dominik Heimann, Frederik Börgel, Henk de Vries, Kim Bachmann, Victoria E Rose, Bastian Frehland, Dirk Schepmann, Laura H Heitman, Bernhard Wünsch
Recently, the development of the fluorinated PET tracer [(18)F]1a for imaging of CB2 receptors in the central nervous system was reported. [(18)F]1a showed high CB2 affinity and selectivity over the CB1 subtype, but rapid biotransformation in mice. In addition to the amide hydrolysis, oxidative N-dealkylation and carbazole oxidation were postulated as main metabolic pathways. Based on these results, novel carbazole derivatives with additional 6-substituents (23a, 24a), modified hydrogenation state (26a) and enlarged fluoroalkyl substituent (13a, 13b) were synthesized and pharmacologically evaluated...
October 16, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29125031/a-rapidly-expanding-calvarial-langerhans-cell-histiocytosis-with-low-ki-67-in-an-adult-a-challenging-diagnosis-on-magnetic-resonance-imaging
#13
Mustafa Kemal Demir, Ozlem Yapıcıer, Teyyub Hasanov, Deniz Kilic, Turker Kilic
Langerhans cell histiocytosis may have a wide variety of clinical presentations. The growth of localised form is usually slow and it mainly involves bones such as the skull, femur, spine, ribs, mandible and pelvis in children. The spectrum of clinical manifestations and magnetic resonance imaging findings of the disease may sometimes mimic infections as well as benign and malignant tumours. In this report, we describe an unusual case of rapidly progressive calvarial Langerhans cell histiocytosis with a painful and tender mass in a 27-year-old man that created diagnostic and therapeutic challenges...
January 1, 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/29122956/characterization-of-age-related-penile-microvascular-hemodynamic-impairment-using-laser-speckle-contrast-imaging-possible-role-of-increased-fibrogenesis
#14
Seung-Ryeol Lee, Ki-Ho Kim, Ho-Song You, Johnny Fu, Tung-Chin Mike Hsieh, Valmik Bhargava, M Raj Rajasekaran
Current technology for penile hemodynamic evaluations in small animals is invasive and has limitations. We evaluated a novel laser speckle contrast imaging (LSCI) technique to determine age-related changes in penile microvascular perfusion (PMP) and tested the role of cavernosal muscle (CC) fibrosis mediated by Wnt-TGF β1 signaling pathways in a mouse model. Ten young (2-3 months) and old (24-28 months) wild-type C57BL6 male mice were subjected to PMP measured using a LSCI system. Penile blood flow (PBF, peak systolic velocity, PSV) was also measured using a color Doppler ultrasound for comparison...
November 2017: Physiological Reports
https://www.readbyqxmd.com/read/29115084/cardiac-magnetic-resonance-predictor-of-ventricular-function-after-surgical-coronary-revascularization
#15
Ho Young Hwang, Sang Yoon Yeom, Jae Woong Choi, Se Jin Oh, Eun Ah Park, Whal Lee, Ki Bong Kim
We evaluated echocardiographic changes of left ventricular (LV) function in coronary artery bypass grafting (CABG) patients with LV dysfunction, and examined cardiac magnetic resonance (CMR) parameters associated with improved LV function. Seventy-seven CABG patients presenting with decreased LV ejection fraction (LVEF, ≤ 35%) and who underwent preoperative gadolinium-enhanced CMR were enrolled. A 16-segment model was used to analyze CMR imaging. A viable myocardial segment was defined as ≤ 50% transmural extent of late gadolinium enhancement...
December 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29113860/dramatic-psychiatric-and-behavioral-symptoms-following-a-subthalamic-lesion
#16
Byung Sun Choi, Guangxun Shen, Guangxian Nan, Jong-Min Kim, Ki-Young Jung, Beomseok Jeon
Neuropsychiatric symptoms have been well documented after subthalamic nucleus deep brain stimulation (STN-DBS), but those following a subthalamic lesion have been rarely reported. Herein, we present a 43-year-old woman with sudden-onset dramatic psychiatric and behavioral symptoms with hemiballism. Brain magnetic resonance imaging (MRI) with fluid attenuated inversion recovery (FLAIR) sequence during the acute phase demonstrated extensive hyperintensity in the left STN and adjacent regions. Contrast-enhanced MRI showed no abnormal areas of enhancement...
November 4, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29112164/effect-of-intranasally-delivered-rh-vegf165-on-angiogenesis-following-cerebral-hypoxia-ischemia-in-the-cerebral-cortex-of-newborn-piglets
#17
Amit Jain, Panagiotis Kratimenos, Ioannis Koutroulis, Amishi Jain, Amulya Buddhavarapu, Jahan Ara
BACKGROUND: Vascular endothelial growth factor (VEGF) stimulates vascular genesis and angiogenesis. Cerebral Hypoxia-Ischemia (HI) leads to the reduction of vasculature in the cerebral cortex of newborn piglets. OBJECTIVE: The present study tests the hypothesis that post-hypoxia intranasal administration of recombinant human VEGF165 (rh-VEGF165) for 3 days increases the vascular density in the cerebral cortex of newborn piglets without promoting neovascularization...
November 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29108024/generation-of-polychromatic-projection-for-dedicated-breast-computed-tomography-simulation-using-anthropomorphic-numerical-phantom
#18
Hosang Jeon, Hanbean Youn, Jin Sung Kim, Jiho Nam, Jayoung Lee, Juhye Lee, Dahl Park, Wontaek Kim, Yongkan Ki, Donghyun Kim
Numerical simulations are fundamental to the development of medical imaging systems because they can save time and effort in research and development. In this study, we developed a method of creating the virtual projection images that are necessary to study dedicated breast computed tomography (BCT) systems. Anthropomorphic software breast phantoms of the conventional compression type were synthesized and redesigned to meet the requirements of dedicated BCT systems. The internal structure of the breast was randomly constructed to develop the proposed phantom, enabling the internal structure of a naturally distributed real breast to be simulated...
2017: PloS One
https://www.readbyqxmd.com/read/29104063/dynamics-of-proofreading-by-the-e-%C3%A2-coli-pol-iii-replicase
#19
Jonghyun Park, Slobodan Jergic, Yongmoon Jeon, Won-Ki Cho, Ryanggeun Lee, Nicholas E Dixon, Jong-Bong Lee
The αɛθ core of Escherichia coli DNA polymerase III (Pol III) associates with the β2 sliding clamp to processively synthesize DNA and remove misincorporated nucleotides. The α subunit is the polymerase while ɛ is the 3' to 5' proofreading exonuclease. In contrast to the polymerase activity of Pol III, dynamic features of proofreading are poorly understood. We used single-molecule assays to determine the excision rate and processivity of the β2-associated Pol III core, and observed that both properties are enhanced by mutational strengthening of the interaction between ɛ and β2...
October 16, 2017: Cell Chemical Biology
https://www.readbyqxmd.com/read/29103468/correlations-between-the-iodine-concentrations-from-dual-energy-computed-tomography-and-molecular-markers-ki-67-and-hif-1%C3%AE-in-rectal-cancer-a-preliminary-study
#20
Shuxuan Fan, Xubin Li, Lei Zheng, Dongzhi Hu, Xiaoyi Ren, Zhaoxiang Ye
PURPOSE: To investigate whether dual energy computed tomography (CT) with iodine quantification is correlated with molecular markers Ki-67and hypoxia-inducible factor 1α (HIF-1α)in rectal cancer (RC). MATERIALS AND METHODS: Eighty patients (43 males and 37 females) diagnosed with rectal cancer got pelvic contrast-enhanced CT scan with dual energy computed tomography before any anticancer treatment. Analyse the normalized iodine concentration (NIC) values and CT values at each energy level (40-140 keV) from the virtual monochromatic image of the primary lesions...
November 2017: European Journal of Radiology
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