keyword
https://read.qxmd.com/read/38535082/comparison-of-tissue-factors-in-the-ontogenetic-aspects-of-human-cholesteatoma
#1
JOURNAL ARTICLE
Kristaps Dambergs, Gunta Sumeraga, Māra Pilmane
BACKGROUND: An acquired cholesteatoma is a benign but locally aggressive lesion in the middle ear. It is characterized by chronic inflammation and the destruction of surrounding bone. Therefore, the aim of this study was to compare defensins HβD-2 and HβD-4; pro- and anti-inflammatory cytokines IL-1α and IL-10; proliferation marker Ki-67; transcription factor NF-κβ; angiogenetic factor VEGF; Sonic hedgehog gene protein SHH; and remodeling factors MMP-2, MMP-9, TIMP-2, and TIMP-4 in adult and pediatric cholesteatoma tissue, and to compare these groups with control skin tissue...
March 21, 2024: Diagnostics
https://read.qxmd.com/read/38532005/author-correction-enhancing-citrus-fruit-yield-investigations-through-flight-height-optimization-with-uav-imaging
#2
Soon-Hwa Kwon, Ki Bon Ku, Anh Tuan Le, Gyung Deok Han, Yosup Park, Jaehong Kim, Thai Thanh Tuan, Yong Suk Chung, Sheikh Mansoor
No abstract text is available yet for this article.
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38528135/ultra-high-b-value-dwi-accurately-identifies-isocitrate-dehydrogenase-genotypes-and-tumor-subtypes-of-adult-type-diffuse-gliomas
#3
JOURNAL ARTICLE
Xueqin Wang, Xinru Shu, Pingping He, Yiting Cai, Yingqian Geng, Xiaomei Hu, Yifan Sun, Huinan Xiao, Wanyi Zheng, Yang Song, Yunjing Xue, Rifeng Jiang
OBJECTIVES: To distinguish isocitrate dehydrogenase (IDH) genotypes and tumor subtypes of adult-type diffuse gliomas based on the fifth edition of the World Health Organization classification of central nervous system tumors (WHO CNS5) in 2021 using standard, high, and ultra-high b-value diffusion-weighted imaging (DWI). MATERIALS AND METHODS: This prospective study enrolled 70 patients with adult-type diffuse gliomas who underwent multiple b-value DWI. Apparent diffusion coefficient (ADC) values including ADCb500/b1000 , ADCb500/b2000 , ADCb500/b3000 , ADCb500/b4000 , ADCb500/b6000 , ADCb500/b8000 , and ADCb500/b10000 in tumor parenchyma (TP) and contralateral normal-appearing white matter (NAWM) were calculated...
March 25, 2024: European Radiology
https://read.qxmd.com/read/38519581/a-phase-iib-randomized-placebo-controlled-trial-testing-the-effect-of-mag-epa-long-chain-omega-3-fatty-acid-dietary-supplement-on-prostate-cancer-proliferation
#4
JOURNAL ARTICLE
Karine Robitaille, Marie-Hélène Guertin, Afshin Jamshidi, Hui Wen Xu, Hélène Hovington, Jean-François Pelletier, Lisanne Beaudoin, Nikunj Gevariya, Louis Lacombe, Rabi Tiguert, Yves Caumartin, Thierry Dujardin, Paul Toren, Michele Lodde, Étienne Racine, Dominique Trudel, Martine Perigny, Thierry Duchesne, Josée Savard, Pierre Julien, Yves Fradet, Vincent Fradet
BACKGROUND: High prostate eicosapentaenoic fatty acid (EPA) levels were associated with a significant reduction of upgrading to grade group (GG) ≥ 2 prostate cancer in men under active surveillance. We aimed to evaluate the effect of MAG-EPA long-chain omega-3 fatty acid dietary supplement on prostate cancer proliferation. METHODS: A phase II double-blind randomized placebo-controlled trial was conducted in 130 men diagnosed with GG ≥ 2 prostate cancer and undergoing radical prostatectomy between 2015-2017 (Clinicaltrials...
March 22, 2024: Commun Med (Lond)
https://read.qxmd.com/read/38519312/sarcopenia-with-decreased-total-psoas-muscle-area-in-children-with-high-risk-neuroblastoma
#5
JOURNAL ARTICLE
Min-Jung Bang, Sanghoon Lee, Ji Won Lee, Wontae Kim, Ki Woong Sung, Jeong-Meen Seo
BACKGROUND: We calculated psoas muscle area (PMA) z-scores in high-risk neuroblastoma patients undergoing treatment to examine the clinical significance of sarcopenia in this cohort. METHODS: We analyzed retrospective data from patients aged 0-18 who were diagnosed with abdominal neuroblastoma between 2005 and 2019 at Samsung Medical Center. Patients categorized as high-risk undergone induction chemotherapy, neuroblastoma excision, and tandem high-dose chemotherapy with autologous stem cell transplantation (HDCT/auto-SCT) were selected...
March 21, 2024: Asian Journal of Surgery
https://read.qxmd.com/read/38518110/efficacy-and-safety-of-prabotulinumtoxina-in-subjects-with-benign-masseteric-hypertrophy-a-double-blind-randomized-placebo-controlled-multicenter-phase-3-trial-and-open-label-extension-study
#6
JOURNAL ARTICLE
Joon Seok, Young Gue Koh, Jun Ki Hong, So Hye Yun, Da Hye Kim, Hyung Seok Son, Sun Young Choi, Kwang Ho Yoo, Yang Won Lee, Beom Joon Kim
BACKGROUND: Despite the widespread use of botulinum toxin (BTX) injection for the treatment of masseter muscle hypertrophy (MMH), there is no standard treatment option. OBJECTIVE: We report the efficacy and safety for BTX in MMH over a period of 48 weeks. METHODS: In double-blinded, placebo-controlled phase 3 trials, 180 patients (randomized 1:1) received treatment with placebo (normal saline) or prabotulinumtoxinA (48 units). Masseter muscle thickness (at maximal clenching and resting positions), 3D imaging analysis, and masseter muscle hypertrophy scale grades were analyzed at each time point...
March 8, 2024: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://read.qxmd.com/read/38513789/prostate-diffusion-weighted-imaging-dwi-in-mr-guided-radiotherapy-reproducibility-assessment-on-1-5%C3%A2-t-mr-linac-and-1-5%C3%A2-t-mr-simulator
#7
JOURNAL ARTICLE
Oi Lei Wong, Jing Yuan, Darren M C Poon, Sin Ting Chiu, Bin Yang, George Chiu, Siu Ki Yu, Kin Yin Cheung
PURPOSE: Diffusion-weighted imaging (DWI) holds promise for image-guided radiotherapy (MRgRT) in prostate cancer. However, challenges persist due to image distortion, artifacts, and apparent diffusion coefficient (ADC) reproducibility issues. This study aimed to assess DWI image quality and ADC reproducibility on both a 1.5 T MR-simulator and a 1.5 T MR-Linac, employing measurements from both an ACR MRI phantom and prostate cancer patients undergoing MRgRT. METHODS: DW-MRI scans were conducted on 19 patients (mean age = 69 ± 8 years, with 23 MR-visible intra-prostatic lesions) and an ACR MRI phantom using a 1...
March 18, 2024: Magnetic Resonance Imaging
https://read.qxmd.com/read/38510825/recent-updates-on-applications-of-artificial-intelligence-for-nuclear-medicine-professionals-bone-scintigraphy
#8
EDITORIAL
Ki-Seong Park, Hee-Seung Henry Bom
No abstract text is available yet for this article.
April 2024: Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/38500864/neoadjuvant-chemohormonal-therapy-before-radical-prostatectomy-in-high-risk-prostate-cancer-a-mini-review
#9
REVIEW
Junjie Fan, Zhangdong Jiang, Guojing Wang, Dalin He, Kaijie Wu
High-risk localized prostate cancer (PCa) has the potential of recurrence and progression to a lethal phenotype, and neoadjuvant therapy followed by radical prostatectomy (RP) may be an option for these patients. Docetaxel has been recently shown to be an effective chemotherapeutic agent for high-volume metastatic hormone-sensitive PCa and metastatic castration-resistant PCa, and these increased efficacy create the impetus to assess the potential role of preoperative docetaxel in high-risk localized PCa. In this mini-review, we found that neoadjuvant chemohormonal therapy (NCHT) may be an effective neoadjuvant regimen to improve oncological outcome of high-risk PCa...
2024: American Journal of Clinical and Experimental Urology
https://read.qxmd.com/read/38499907/exploring-a-multiparameter-mri-based-radiomics-approach-to-predict-tumor-proliferation-status-of-serous-ovarian-carcinoma
#10
JOURNAL ARTICLE
Li Liu, Ling Zhao, Yang Jing, Dan Li, Hua Linghu, Haiyan Wang, Linyi Zhou, Yuan Fang, Yongmei Li
OBJECTIVES: To develop a multiparameter magnetic resonance imaging (MRI)-based radiomics approach that can accurately predict the tumor cell proliferation status of serous ovarian carcinoma (SOC). MATERIALS AND METHODS: A total of 134 patients with SOC who met the inclusion and exclusion criteria were retrospectively screened from institution A, spanning from January 2016 to March 2022. Additionally, an external validation set comprising 42 SOC patients from institution B was also included...
March 18, 2024: Insights Into Imaging
https://read.qxmd.com/read/38499895/neuroendocrine-tumor-of-the-appendix-masquerading-as-acute-appendicitis-with-a-mucocele-on-ct-scan-a-rare-finding
#11
JOURNAL ARTICLE
Abdullah S Al-Darwish, Waad Rashaid Alsubaie, Waleed AlShammari, Muath AlaSheikh, Muath AlRashed
INTRODUCTION: Neuroendocrine tumors (NETs) of the appendix are rare and are often discovered incidentally during surgery for acute appendicitis or other unrelated conditions (Modlin et al. in Gastroenterology 128:1717-1751, 2005, Alsaad et al. in Oncol Rep 16:1105-1109, 2006, Frilling et al. in Lancet Oncol 15:e8-e21, 2014). These tumors can range from asymptomatic incidental findings to clinically significant tumors with metastases (Alsaad et al. in Oncol Rep 16:1105-1109, 2006, Gomes et al...
March 19, 2024: Surgical Case Reports
https://read.qxmd.com/read/38499794/macular-hole-with-epiretinal-proliferation-diagnostic-value-of-en-face-optical-coherence-tomography-and-clinical-characteristics
#12
JOURNAL ARTICLE
Jaehwan Choi, Sang Jin Kim, Se Woong Kang, Ki Young Son, Sungsoon Hwang
PURPOSE: To elucidate the clinical features and surgical outcomes of full-thickness macular hole (FTMH) with epiretinal proliferation (EP) diagnosed by both en-face and B-mode optical coherence tomography (OCT). METHOD: This retrospective cohort study classified idiopathic FTMHs into two groups, based on B-scan and en-face OCT imaging: FTMH with EP (EP group) and without EP (non-EP group). The preoperative features, as well as postoperative outcomes up to 12 months, were compared between the two groups...
March 19, 2024: Graefe's Archive for Clinical and Experimental Ophthalmology
https://read.qxmd.com/read/38498246/solid-pseudopapillary-neoplasm-spn-of-the-pancreas-current-understanding-on-its-malignant-potential-and-management
#13
REVIEW
Xiaoyue Lu, Hao Chen, Taiping Zhang
Solid pseudopapillary neoplasms (SPN) of the pancreas are presently recognized as low-grade malignant tumors that are frequently observed in young females. This tumor has a low incidence and is associated with an excellent prognosis following surgical resection. Typical SPNs primarily affect the pancreas and tend to have moderate or asymptomatic manifestations. Based on retrospective research, it is anticipated that patients with SPN can achieve disease-free survival, even in cases when metastasis is detected during inspection...
March 18, 2024: Discover. Oncology
https://read.qxmd.com/read/38490447/genetically-distinct-oligosarcoma-arising-from-oligodendroglioma-systematic-review-illustrative-case-example
#14
JOURNAL ARTICLE
Alexander Evans, Kiana Y Prather, James Battiste, Kar-Ming Fung, Ian F Dunn, Christopher S Graffeo
BACKGROUND: Oligosarcoma is a rare central nervous system (CNS) neoplasm that may arise following oligodendroglioma resection, which demonstrates a unique genetic profile and aggressive clinical phenotype. We present a systematic review and illustrative case example emphasizing the clinical and prognostic features of this unusual and unfavorable neuro-oncologic disease. METHODS: Systematic literature review and illustrative case report. RESULTS: A 41-year-old man who had undergone two neurosurgical resections for a WHO grade II oligodendroglioma (Ki-67=5-10%, 1p/19q co-deleted, IDH2 mutated), without adjuvant chemoradiation, presented with seizures seven years after resection...
March 13, 2024: World Neurosurgery
https://read.qxmd.com/read/38489038/deep-learning-based-multi-parametric-magnetic-resonance-imaging-mp-mri-nomogram-for-predicting-ki-67-expression-in-rectal-cancer
#15
JOURNAL ARTICLE
Sikai Wu, Neng Wang, Weiqun Ao, Jinwen Hu, Wenjie Xu, Guoqun Mao
PURPOSE: To explore the value of deep learning-based multi-parametric magnetic resonance imaging (mp-MRI) nomogram in predicting the Ki-67 expression in rectal cancer. METHODS: The data of 491 patients with rectal cancer from two centers were retrospectively analyzed and divided into training, internal validation, and external validation sets. They were categorized into high- and low-expression group based on postoperative pathological Ki-67 expression. Each patient's mp-MRI data were analyzed to extract and select the most relevant features of deep learning, and a deep learning model was constructed...
March 15, 2024: Abdominal Radiology
https://read.qxmd.com/read/38488831/open-top-bessel-beam-two-photon-light-sheet-microscopy-for-three-dimensional-pathology
#16
JOURNAL ARTICLE
Won Yeong Park, Jieun Yun, Jinho Shin, Byung Ho Oh, Gilsuk Yoon, Seung-Mo Hong, Ki Hean Kim
Nondestructive pathology based on three-dimensional (3D) optical microscopy holds promise as a complement to traditional destructive hematoxylin and eosin (H&E) stained slide-based pathology by providing cellular information in high throughput manner. However, conventional techniques provided superficial information only due to shallow imaging depths. Herein, we developed open-top two-photon light sheet microscopy (OT-TP-LSM) for intraoperative 3D pathology. An extended depth of field two-photon excitation light sheet was generated by scanning a nondiffractive Bessel beam, and selective planar imaging was conducted with cameras at 400 frames/s max during the lateral translation of tissue specimens...
March 15, 2024: ELife
https://read.qxmd.com/read/38487075/risk-factors-and-cognitive-correlates-of-white-matter-hyperintensities-in-ethnically-diverse-populations-without-dementia-the-cosmic-consortium
#17
JOURNAL ARTICLE
Keshuo Lin, Wei Wen, Darren M Lipnicki, Louise Mewton, Rory Chen, Jing Du, Dadong Wang, Ingmar Skoog, Therese Rydberg Sterner, Jenna Najar, Ki Woong Kim, Ji Won Han, Jun Sung Kim, Tze Pin Ng, Roger Ho, Denise Qian Ling Chua, Kaarin J Anstey, Nicolas Cherbuin, Moyra E Mortby, Henry Brodaty, Nicole Kochan, Perminder S Sachdev, Jiyang Jiang
INTRODUCTION: White matter hyperintensities (WMHs) are an important imaging marker for cerebral small vessel diseases, but their risk factors and cognitive associations have not been well documented in populations of different ethnicities and/or from different geographical regions. METHODS: We investigated how WMHs were associated with vascular risk factors and cognition in both Whites and Asians, using data from five population-based cohorts of non-demented older individuals from Australia, Singapore, South Korea, and Sweden ( N  = 1946)...
2024: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://read.qxmd.com/read/38485272/can-internal-carotid-arteries-be-used-for-noninvasive-quantification-of-brain-pet-studies
#18
JOURNAL ARTICLE
Laura Providência, Chris W J van der Weijden, Philipp Mohr, Joyce van Sluis, Johannes H van Snick, Riemer H J A Slart, Rudi A J O Dierckx, Adriaan A Lammertsma, Charalampos Tsoumpas
Because of the limited axial field of view of conventional PET scanners, the internal carotid arteries are commonly used to obtain an image-derived input function (IDIF) in quantitative brain PET. However, time-activity curves extracted from the internal carotids are prone to partial-volume effects due to the limited PET resolution. This study aimed to assess the use of the internal carotids for quantifying brain glucose metabolism before and after partial-volume correction. Methods: Dynamic [18 F]FDG images were acquired on a 106-cm-long PET scanner, and quantification was performed with a 2-tissue-compartment model and Patlak analysis using an IDIF extracted from the internal carotids...
March 14, 2024: Journal of Nuclear Medicine
https://read.qxmd.com/read/38482252/an-unexpected-case-of-large-cell-neuroendocrine-carcinoma-of-the-colon-a-case-report
#19
Kingsley Nnawuba, Dylan Travis, Hanna Jensen, Blake Lockwood
BACKGROUND: Patients presenting with large cell neuroendocrine carcinomas (LCNECs) comprise a small minority of total colon and rectal cancers (1-2%) with poor prognostic outcomes in lieu of late diagnosis and metastasis at the point of diagnosis. CASE DESCRIPTION: We report a case presentation of a 69-year-old male presenting with diffuse, non-severe upper abdominal pain and a positive at-home colon cancer screening test. At the time of presentation, the patient was negative for constipation or blood in stool...
February 29, 2024: Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38482224/the-influencing-factors-for-tumor-thrombus-in-patients-with-hepatocellular-carcinoma
#20
JOURNAL ARTICLE
Jianbing Ma, Dan Li, Xiaoli Zhu
BACKGROUND: Microvascular invasion (MVI) is considered to be an important factor in the early invasion and metastasis of liver cancer, and the survival rate of patients with MVI is much lower than that of patients without MVI. Therefore, it is crucial to accurately predict the independent predictors of tumor thrombus formation. This study aimed to assess the risk factors for tumor thrombus grades in patients with hepatocellular carcinoma (HCC). METHODS: Between August 2011 and December 2022, the data of 231 patients diagnosed with HCC were collected and divided into the following three groups: an MVI-negative group, an MVI-positive group, and a portal vein tumor thrombus (PVTT) group...
February 29, 2024: Journal of Gastrointestinal Oncology
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