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https://www.readbyqxmd.com/read/29778598/relevance-of-antiplatelet-therapy-duration-after-stent-assisted-coil-embolization-for-unruptured-intracranial-aneurysms
#1
Tackeun Kim, Chang Hyeun Kim, Si-Hyuck Kang, Seung Pil Ban, O-Ki Kwon
BACKGROUND: The optimal duration of dual antiplatelet therapy (DAPT) for preventing delayed thromboembolic events (DTEs) remains unclear. We aimed to determine whether longer DAPT provides improved protection against delayed DTEs. METHODS: This retrospective cohort study included 507 stent-assisted coil embolization procedures using a single stent for unruptured intracranial aneurysms. We performed coarsened exact matching according to the duration of maintenance DAPT...
May 17, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29775151/selection-of-endoscopic-or-transcranial-surgery-for-tuberculum-sellae-meningiomas-according-to-specific-anatomical-features-a-retrospective-multicenter-analysis-kosen-002
#2
Doo-Sik Kong, Chang-Ki Hong, Sang Duk Hong, Do-Hyun Nam, Jung-Il Lee, Ho Jun Seol, Jiwoong Oh, Dong Gyu Kim, Yong Hwy Kim
OBJECTIVE The endoscopic endonasal approach (EEA) and the transcranial approach (TCA) are good options for the treatment of tuberculum sellae (TS) meningiomas. The objective of this study was to identify the key anatomical features in TS meningiomas and compare the two surgical approaches. METHODS The authors retrospectively reviewed clinical data in 178 patients with TS meningiomas treated at 3 institutions between January 2010 and July 2016. Patients with tumors encasing the internal carotid artery or anterior cerebral artery or involving the anterior clinoid process or cavernous sinus were excluded...
May 18, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29772361/comparative-histological-and-molecular-analysis-of-two-recurrent-lesions-showing-different-mr-imaging-responses-after-bevacizumab-treatment-report-of-a-case-of-anaplastic-astrocytoma
#3
Yoshihiro Otani, Tomotsugu Ichikawa, Atsuhito Uneda, Kazuhiko Kurozumi, Joji Ishida, Isao Date
BACKGROUND: We report the case of a patient with anaplastic astrocytoma whose two recurrent lesions showed different imaging responses from one another after bevacizumab treatment. Histological and genetic features of this patient are also described. CASE DESCRIPTION: A 31-year-old patient with left temporal anaplastic astrocytoma received surgery, local radiotherapy, and chemotherapy. Recurrent lesions appeared in the cerebellar vermis and left cerebellar hemisphere, and the patient was started on biweekly bevacizumab...
May 14, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29771727/modeling-gadoxetate-liver-uptake-and-efflux-using-dynamic-contrast-enhanced-magnetic-resonance-imaging-enables-preclinical-quantification-of-transporter-drug-drug-interactions
#4
Leonidas Georgiou, Jeffrey Penny, Glynis Nicholls, Neil Woodhouse, François-Xavier Blé, Josephine H Naish, Penny L Hubbard Cristinacce
OBJECTIVES: The aim of this study was to model the in vivo transporter-mediated uptake and efflux of the hepatobiliary contrast agent gadoxetate in the liver. The efficacy of the proposed technique was assessed for its ability to provide quantitative insights into drug-drug interactions (DDIs), using rifampicin as inhibitor. MATERIALS AND METHODS: Three groups of C57 mice were scanned twice with a dynamic gadoxetate-enhanced magnetic resonance imaging protocol, using a 3-dimensional spoiled gradient-echo sequence for approximately 72 minutes...
May 15, 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29765520/histogram-analysis-parameters-of-dynamic-contrast-enhanced-magnetic-resonance-imaging-can-predict-histopathological-findings-including-proliferation-potential-cellularity-and-nucleic-areas-in-head-and-neck-squamous-cell-carcinoma
#5
Alexey Surov, Hans Jonas Meyer, Leonard Leifels, Anne-Kathrin Höhn, Cindy Richter, Karsten Winter
Our purpose was to analyze possible associations between histogram analysis parameters of dynamic contrast-enhanced magnetic resonance imaging DCE MRI and histopathological findings like proliferation index, cell count and nucleic areas in head and neck squamous cell carcinoma (HNSCC). 30 patients (mean age 57.0 years) with primary HNSCC were included in the study. In every case, histogram analysis parameters of Ktrans , Ve , and Kep were estimated using a mathlab based software. Tumor proliferation index, cell count, and nucleic areas were estimated on Ki 67 antigen stained specimens...
April 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29762853/caffeine-induces-metformin-anticancer-effect-on-fibrosarcoma-in-hamsters
#6
D J Popović, D Lalošević, D Miljković, K J Popović, I Čapo, J K Popović
OBJECTIVE: We investigated the effect of metformin and caffeine on fibrosarcoma in hamsters. MATERIALS AND METHODS: 32 Syrian golden hamsters of both sexes, weighing approximately 100 g, were randomly allocated to 3 experimental and 2 control groups, with a minimum of 6 animals per group. 2 x 106 BHK-21/C13 cells in 1 ml were injected subcutaneously into the animals' back in 4 groups. The first experimental group started peroral treatment with metformin 500 mg/kg daily, the second with caffeine 100 mg/kg daily and the third with a combination of metformin 500 mg/kg and caffeine 100 mg/kg daily, via a gastric probe 3 days before tumor inoculation...
April 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29758996/patterns-of-malignant-non-mass-enhancement-on-3-t-breast-mri-help-predict-invasiveness-using-the-bi-rads-lexicon-fifth-edition
#7
Seung Min Lee, Kyung Jin Nam, Ki Seok Choo, Jin You Kim, Dong Wook Jeong, Hyun Yul Kim, Jee Yeon Kim
Background Non-mass enhancements (NME) with invasive components account for 10-42% of total malignant NMEs. The factors associated with invasiveness on magnetic resonance imaging (MRI) could be useful for clinical assessment and treatment. Purpose To evaluate the clinical significances of the distributions and internal enhancement patterns (IEP) of malignant NMEs on 3-T breast MRI. Material and Methods A total of 448 consecutive women with newly diagnosed breast cancer that had undergone preoperative MRI and surgery between February 2013 and March 2016 were identified...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29756310/folate-receptor-targeted-19-f-mr-molecular-imaging-and-proliferation-evaluation-of-lung-cancer
#8
Xiuan Xu, Yuling Yan, Fang Liu, Lina Wu, Mengping Shao, Kai Wang, Xilin Sun, Yingbo Li, Ernest Sanyare Warmann Beinpuo, Baozhong Shen
BACKGROUND: Folate receptors (FRs) hold great potential as important diagnostic and prognostic biological marker for cancer. PURPOSE: To assess the targeted capability of the FR-targeted perfluorocarbon (PFC) nanoparticles and to assess in vivo the relationship between FR expression and tumor proliferation with fluorine-19 (19 F) MR molecular imaging. STUDY TYPE: Prospective animal cancer model. ANIMAL MODEL: H460 (n = 14) and A549 (n = 14) nude mice subcutaneous tumor models...
May 13, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29756265/web-based-thyroid-imaging-reporting-and-data-system-malignancy-risk-of-atypia-of-undetermined-significance-or-follicular-lesion-of-undetermined-significance-thyroid-nodules-calculated-by-a-combination-of-ultrasonography-features-and-biopsy-results
#9
Young Jun Choi, Jung Hwan Baek, Jung Hee Shin, Woo Hyun Shim, Seon-Ok Kim, Won-Hong Lee, Dong Eun Song, Tae Yong Kim, Ki-Wook Chung, Jeong Hyun Lee
BACKGROUND: The purpose of this study was to construct a web-based predictive model using ultrasound characteristics and subcategorized biopsy results for thyroid nodules of atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) to stratify the risk of malignancy. METHODS: Data included 672 thyroid nodules from 656 patients from a historical cohort. We analyzed ultrasound images of thyroid nodules and biopsy results according to nuclear atypia and architectural atypia...
May 13, 2018: Head & Neck
https://www.readbyqxmd.com/read/29755405/dual-paraneoplastic-endocrine-syndromes-heralding-onset-of-extrapulmonary-small-cell-carcinoma-a-case-report-and-narrative-review
#10
Jill B Feffer, Natalia M Branis, Jeanine B Albu
Objective: Extrapulmonary small cell carcinoma (EPSCC) is rare and frequent metastases at presentation can complicate efforts to identify a site of origin. In particular, SCC comprises <1% of prostate cancers and has been implicated in castration resistance. Methods: Clinical, laboratory, imaging, and pathology data are presented. Results: A 56-year-old man with locally advanced prostate adenocarcinoma on androgen deprivation therapy presented with a clogged nephrostomy tube...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29755299/-in-vivo-6-18-f-fluoroacetamido-1-hexanoicanilide-pet-imaging-of-altered-histone-deacetylase-activity-in-chemotherapy-induced-neurotoxicity
#11
Nobuyoshi Fukumitsu, Skye Hsin-Hsien Yeh, Leo Garcia Flores Ii, Uday Mukhopadhyay, Daniel Young, Kazuma Ogawa, Hwan-Jeong Jeong, William Tong, Juri G Gelovani
Background: Histone deacetylases (HDACs) regulate gene expression by changing histone deacetylation status. Neurotoxicity is one of the major side effects of cisplatin, which reacts with deoxyribonucleic acid (DNA) and has excellent antitumor effects. Suberoylanilide hydroxamic acid (SAHA) is an HDAC inhibitor with neuroprotective effects against cisplatin-induced neurotoxicity. Purpose: We investigated how cisplatin with and without SAHA pretreatment affects HDAC expression/activity in the brain by using 6-([18 F]fluoroacetamido)-1-hexanoicanilide ([18 F]FAHA) as a positron emission tomography (PET) imaging agent for HDAC IIa...
2018: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29754669/comparison-of-fractional-flow-reserve-and-intravascular-ultrasound-guided-intervention-strategy-for-clinical-outcomes-in-patients-with-intermediate-stenosis-flavour-rationale-and-design-of-a-randomized-clinical-trial
#12
Jeehoon Kang, Bon-Kwon Koo, Xinyang Hu, Joo Myung Lee, Joo-Yong Hahn, Hyoung-Mo Yang, Eun-Seok Shin, Chang-Wook Nam, Joon-Hyung Doh, Bong-Ki Lee, Chul Ahn, JianAn Wang, Seung-Jae Tahk
BACKGROUND: Coronary angiography has limitations in defining the ischemia-causing stenotic lesion, especially in cases with intermediate coronary stenosis. Fractional flow reserve (FFR) is a current standard method to define the presence of ischemia, and intravascular ultrasound (IVUS) is the most commonly used invasive imaging tool that can provide the lesion geometry and can provide the information on plaque vulnerability. The primary aim of this study is to compare the safety and efficacy of FFR-guided and IVUS-guided percutaneous coronary intervention (PCI) strategies in patients with intermediate coronary stenosis...
May 2018: American Heart Journal
https://www.readbyqxmd.com/read/29752868/comparison-between-reflectance-confocal-microscopy-and-two-photon-microscopy-in-early-detection-of-cutaneous-radiation-injury-in-a-mouse-model-in-vivo
#13
Won Hyuk Jang, Soonjae Kwon, Sehwan Shim, Won-Suk Jang, Jae Kyung Myung, Sejung Yang, Sunhoo Park, Ki Hean Kim
Cutaneous radiation injury (CRI) is a skin injury caused by high dose exposure of ionizing radiation (IR). For proper treatment, early detection of CRI before clinical symptoms is important. Optical microscopic techniques such as reflectance confocal microscopy (RCM) and two-photon microscopy (TPM) have been tested as the early diagnosis method by detecting cellular changes. In this study, RCM and TPM were compared in the detection of cellular changes caused by CRI in an in-vivo mouse model. CRI was induced on the mouse hindlimb skin with various IR doses and the injured skin regions were imaged longitudinally by both modalities until the onset of clinical symptoms...
May 12, 2018: Journal of Biophotonics
https://www.readbyqxmd.com/read/29750944/ellipsoid-zone-change-according-to-glaucoma-stage-advancement
#14
Ahnul Ha, Young Kook Kim, Jin Wook Jeoung, Ki Ho Park
PURPOSE: Retinal photoreceptor ellipsoid zone (EZ) intensity comparison between normal eyes and those with different stages of glaucoma. DESIGN: Retrospective cross-sectional study METHODS: The study included 37 normal, 38 pre-perimetric, 39 mild-to-moderate (visual field [VF] mean deviation [MD]: -7.7±2.0 dB), and 36 severe glaucoma eyes (VF MD: -17.8±3.2 dB). The subjects underwent high-resolution horizontal and vertical-line scans through the fovea by spectral-domain optical coherence tomography [SD-OCT] (Spectralis HRA+OCT; Heidelberg)...
May 8, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29748203/comparative-analysis-of-diffusional-kurtosis-imaging-diffusion-tensor-imaging-and-diffusion-weighted-imaging-in-grading-and-assessing-cellular-proliferation-of-meningiomas
#15
L Lin, R Bhawana, Y Xue, Q Duan, R Jiang, H Chen, X Chen, B Sun, H Lin
BACKGROUND AND PURPOSE: An accurate evaluation of the World Health Organization grade and cellular proliferation is particularly important in meningiomas. Our aim was to prospectively evaluate and compare diffusional kurtosis imaging, DTI, and DWI metrics in determining the grade and cellular proliferation of meningiomas. MATERIALS AND METHODS: Ninety-six consecutive patients with histopathologically confirmed meningiomas were included in this study. Mean kurtosis, radial kurtosis, axial kurtosis, fractional anisotropy, mean diffusivity, and ADC were semiautomatically obtained in the solid components of tumors...
May 10, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29745085/significance-of-nuclear-magnetic-resonance-combined-with-ki-67-and-vegf-detection-in-the-diagnosis-and-prognosis-evaluation-of-brain-glioma
#16
Xuexia Yuan, Deguo Liu, Yanhui Wang, Xiaoxia Li
PURPOSE: To investigate the significance of nuclear magnetic resonance (NMR) combined with Ki-67 and vascular endothelial growth factor (VEGF) detection in the diagnosis and prognosis evaluation of brain glioma. METHODS: 78 patients with brain glioma treated at the Affiliated Hospital of Jining Medical University from January 2015 to August 2017 were studied. All patients underwent the NMR diffusion tensor imaging examination. The expressions of Ki-67 and VEGF in brain glioma tissues were detected using immunohistochemistry and survival analyses were performed for patients in high apparent diffusion coefficient (ADC) group and low ADC group, high-expression Ki-67 and VEGF group and low-expression Ki-67 and VEGF group before treatment...
March 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29740035/antimicrobial-photodynamic-therapy-mediated-by-methylene-blue-and-potassium-iodide-to-treat-urinary-tract-infection-in-a-female-rat-model
#17
Ying-Ying Huang, Anton Wintner, Patrick C Seed, Timothy Brauns, Jeffrey A Gelfand, Michael R Hamblin
Drug-resistant urinary tract infections (UTIs) are difficult and sometimes impossible to treat. Many UTIs are caused by uropathogenic Escherichia coli (UPEC). We developed an intact rat model of UTI, by catheterizing female rats and introducing a bioluminescent UPEC strain into the female rat bladder which lasted for up to six days. We recently showed that antimicrobial photodynamic inactivation (aPDI) of a bacterial infection mediated by the well-known phenothiazinium salt, methylene blue (MB) could be strongly potentiated by addition of the non-toxic salt potassium iodide (KI)...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29738910/first-demonstration-of-in-vivo-mapping-for-regional-brain-monoacylglycerol-lipase-using-pet-with-11-c-sar127303
#18
Tomoteru Yamasaki, Wakana Mori, Yiding Zhang, Akiko Hatori, Masayuki Fujinaga, Hidekatsu Wakizaka, Yusuke Kurihara, Lu Wang, Nobuki Nengaki, Tomoyuki Ohya, Steven H Liang, Ming-Rong Zhang
Monoacylglycerol lipase (MAGL) is a main regulator of the endocannabinoid system within the central nervous system (CNS). Recently, [11 C]SAR127303 was developed as a promising radioligand for MAGL imaging. In this study, we aimed to quantify regional MAGL concentrations in the rat brain using positron emission tomography (PET) with [11 C]SAR127303. An irreversible two-tissue compartment model (2-TCMi, k4  = 0) analysis was conducted to estimate quantitative parameters (k3 , Ki 2-TCMi , and λk3 ). These parameters were successfully obtained with high identifiability (<10 %COV) for the following regions ranked in order from highest to lowest: cingulate cortex > striatum > hippocampus > thalamus > cerebellum > hypothalamus ≈ pons...
May 5, 2018: NeuroImage
https://www.readbyqxmd.com/read/29734483/role-of-dynamic-contrast-enhanced-mri-in-evaluating-the-association-between-contralateral-parenchymal-enhancement-and-survival-outcome-in-er-positive-her2-negative-node-negative-invasive-breast-cancer
#19
Gi Won Shin, Yang Zhang, Min Jung Kim, Min-Ying Su, Eun-Kyung Kim, Hee Jung Moon, Jung Hyun Yoon, Vivian Youngjean Park
BACKGROUND: Background parenchymal enhancement (BPE) on dynamic contrast-enhanced (DCE)-MRI has been associated with breast cancer risk, both based on qualitative and quantitative assessments. PURPOSE: To investigate whether BPE of the contralateral breast on preoperative DCE-MRI is associated with therapy outcome in ER-positive, HER2-negative, node-negative invasive breast cancer. STUDY TYPE: Retrospective. POPULATION: In all, 289 patients with unilateral ER-positive, HER2-negative, node-negative breast cancer larger than 5 mm...
May 7, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29732358/anatomical-popliteal-artery-entrapment-syndrome
#20
Yong Jae Kwon, Tae-Won Kwon, Jun Gyo Gwon, Yong-Pil Cho, Seung-Jun Hwang, Ki-Young Go
Purpose: The aim of this study was to analyze anatomical popliteal artery entrapment syndrome (PAES) and to individualize the treatment of this condition according to the anatomical status of the artery and the adjacent structure. Methods: A total of 35 anatomical PAES legs in 23 consecutive patients treated within the Asan Medical Center, Seoul, Korea between 1995 and 2011 were analyzed retrospectively. Anatomical PAES was diagnosed by MRI and/or CT scans of the knee joint, and CT or conventional transfemoral arteriography of the lower extremities...
May 2018: Annals of Surgical Treatment and Research
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