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Ty Bereskie, Manuel J Rodriguez, Rehan Sadiq
Drinking water management in Canada is complex, with a decentralized, three-tiered governance structure responsible for safe drinking water throughout the country. The current approach has been described as fragmented, leading to governance gaps, duplication of efforts, and an absence of accountability and enforcement. Although there have been no major waterborne disease outbreaks in Canada since 2001, a lack of performance improvement, especially in small drinking water systems, is evident. The World Health Organization water safety plan approach for drinking water management represents an alternative preventative management framework to the current conventional, reactive drinking water management strategies...
April 19, 2017: Environmental Management
Tae Yokoi, Dan Zhu, Hong Sheng Bi, Jost B Jonas, Rahul A Jonas, Natsuko Nagaoka, Muka Moriyama, Takeshi Yoshida, Kyoko Ohno-Matsui
Purpose: To analyze morphologic features of segmental parapapillary diffuse choroidal atrophy (PDCA) in children. Methods: The study group included children (age ≤15 years) with high myopia who attended the Tokyo High Myopia Clinic. Control groups comprised participants of the population-based Gobi Desert Children Eye Study (GobiDCES). Fundus photographs were examined for presence of PDCA and choroidal thickness (CT) was measured by optical coherence tomography...
February 1, 2017: Investigative Ophthalmology & Visual Science
Stephen F Rechner, Douglas M VanDrie, Ralph N Rogers
132 Background: In response to the FDA safety communication we banned the use of intracorporeal morcellation effective April 22(nd) 2014. Clinicians expressed frustration and a concern that an increase in the abdominal hysterectomy rate or percentage, wound complications, and length of stay would occur. Our PDCA (plan, do, check, and act) safety process reviewed these quality and safety metrics one year later. METHODS: This is a retrospective evaluation of a prospective institutional decision...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
J Xie, J Wang, J P, J Chen, W Hu
PURPOSE: To optimize the clinical processes of radiotherapy and to reduce the radiotherapy risks by implementing the powerful risk management tools of failure mode and effects analysis(FMEA) and PDCA(plan-do-check-act). METHODS: A multidiciplinary QA(Quality Assurance) team from our department consisting of oncologists, physicists, dosimetrists, therapists and administrator was established and an entire workflow QA process management using FMEA and PDCA tools was implemented for the whole treatment process...
June 2016: Medical Physics
Lauren Rakes, Mary King, Brian Johnston, Randall Chesnut, Rosemary Grant, Monica Vavilala
Severe traumatic brain injury (TBI) is a leading cause of morbidity and mortality in children. In 2003 and 2012, the Brain Trauma Foundation established and refined evidence-based guidelines for management of severe TBI in children. A recent multicenter study demonstrated an association between TBI guideline adherence and improved discharge survival. However, this study also showed large variation in adherence to pediatric TBI management at our level 1 pediatric trauma center, where overall adherence to fourteen pediatric intensive care unit (PICU) TBI clinical indicators was 64%...
2016: BMJ Quality Improvement Reports
Hong-Yan Wang, Ling-Na Han, Xiao-Hua Zhu, Hong-Mei Ma, Ya-Ping Pan
PURPOSE: To evaluate the effect of PDCA teaching mode on clinical ability in the process of periodontal clinical internship. METHODS: Forty-eight undergraduate interns coming from School of Stomatology, China Medical University were divided into 2 groups, one group received traditional teaching mode, the other group received a teaching mode based on PDCA cycle. At the end of internship, every student was assessed by theoretical examinations, case reports and clinical skill practice...
August 2016: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
Meng-Yi Wang, Zhe-Yu Niu, Xiang-Gao Gao, Li Zhou, Quan Liao, Yu-Pei Zhao
<strong>Objective</strong> To examine the expression of cell division cycle associated 2 (CDCA 2) in pancreatic ductal adenocarcinoma (PDAC) and investigate its role in prognosis of PDAC patients. <strong>Methods</strong> This retrospective study included 155 PDAC patients who underwent surgical treatment and complete post-operative follow-up. Clinicopathologic data were collected through clinical database. Tissue microarray was constructed and immunohistochemistry was performed to detect CDCA2 expression in the PDAC tumor tissues and adjacent non-tumor tissues...
September 20, 2016: Chinese Medical Sciences Journal, Chung-kuo i Hsüeh K'o Hsüeh Tsa Chih
Clément Provost, Giulia Piccinini, Sophie Tasseel-Ponche, Pierre Lozeron, Bertrand Arnulf, Alain Yelnik
OBJECTIVE: As proposed after stroke, the study of reactions to a sensory stimulation allows to a better understanding of postural strategies. Below, we provide the analysis in chronic acquired demyelinating polyneuropathies (CADP). MATERIAL/PATIENTS AND METHODS: Prospective study of 25 healthy subjects (57±12years, 8M, 17F) and 25 CADP (66±14years, 20M, 5F) on stabilometric platform (Techno-Concept(®), France). Proprioception was disturbed by tendon vibration on Triceps Surae (TS) and Tibialis Anterior (TA)...
September 2016: Annals of Physical and Rehabilitation Medicine
Ruqaya Shaikh, Najma Memon, Amber R Solangi, Huma I Shaikh, Muhammad Hassan Agheem, Syed Abid Ali, Muhammad Raza Shah, Aftab Kandhro
Selectivity of gold nanoparticles (AuNPs) depends upon surface functionality; small changes in structure or concentration bring significant changes in the behavior of AuNPs. In this study, citrate-capped AuNPs were functionalized with ortho-dicarboxylate substituted pyridine (2,3-PDCA) and detailed studies on experimental conditions were carried out to check the stability of AuNPs and response for Cr(3+). Stability of PDCA-AuNPs was found sensitive to the pH, ionic strength of buffer and its type. Capping behavior of PDCA on C-AuNPs was examined by FTIR spectroscopy...
February 15, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Erica B Stein, Peter S Liu, Ella A Kazerooni, Karen Barber, Matthew S Davenport
OBJECTIVE: The objective of our study was to reduce variation in image quality of orthogonal reformatted images generated from long-z-axis CT angiography (CTA) studies of the upper and lower extremities. SUBJECTS AND METHODS: Upper and lower extremity CTA studies were targeted at a single health care system. A correctly performed CTA examination was defined as one that met the following three criteria: Sagittal and coronal reformats were obtained, a high-resolution matrix greater than 512 × 512 was used, and reformatted images were available in a distance-measurable format...
December 2016: AJR. American Journal of Roentgenology
Lianyuan Tao, Lingfu Zhang, Ying Peng, Ming Tao, Gang Li, Dianrong Xiu, Chunhui Yuan, Chaolai Ma, Bin Jiang
As a poor prognosis indicator in patients with pancreatic ductal adenocarcinoma (PDCA), lymph node (LN) metastasis is of great importance in treatment. Present study was performed to evaluate the predictive value of preoperative neutrophil-to-lymphocyte ratio (NLR), Platelet-to-lymphocyte ratio (PLR) and possible clinical parameters on the LN metastasis in PDCA patients. A total of 159 operable patients with PDCA were enrolled in our study. The clinical utility of NLR and other clinical parameters was evaluated by receiver operating characteristic (ROC) curves...
November 8, 2016: Oncotarget
Jacqueline Jones, Angana Mukherjee, Balasubramanyam Karanam, Melissa Davis, Jesse Jaynes, R Renee Reams, Windy Dean-Colomb, Clayton Yates
Kaiso, a bi-modal transcription factor, regulates gene expression, and is elevated in breast, prostate, and colon cancers. Depletion of Kaiso in other cancer types leads to a reduction in markers for the epithelial-mesenchymal transition (EMT) (Jones et al., 2014), however its clinical implications in pancreatic ductal adenocarcinoma (PDCA) have not been widely explored. PDCA is rarely detected at an early stage but is characterized by rapid progression and invasiveness. We now report the significance of the subcellular localization of Kaiso in PDCAs from African Americans...
October 1, 2016: Cancer Letters
Mustafa Khan, Parwaiz Khalid, Youssef Al-Said, Edward Cupler, Lamia Almorsy, Mohamed Khalifa
Turnaround time is one of the most important healthcare performance indicators. King Faisal Specialist Hospital and Research Center in Jeddah, Saudi Arabia worked on reducing the reports turnaround time of the neurophysiology lab from more than two weeks to only five working days for 90% of cases. The main quality improvement methodology used was the FOCUS PDCA. Using root cause analysis, Pareto analysis and qualitative survey methods, the main factors contributing to the delay of turnaround time and the suggested improvement strategies were identified and implemented, through restructuring transcriptionists daily tasks, rescheduling physicians time and alerting for new reports, engaging consultants, consistent coordination and prioritizing critical reports...
2016: Studies in Health Technology and Informatics
Mustafa Khan, Parwaiz Khalid, Lamia Almorsy, Mohamed Khalifa
Timeliness and accessibility of healthcare services reflect system's capacity to provide care quickly after a need is recognized. King Faisal Specialist Hospital and Research Center in Jeddah, Saudi Arabia worked on improving timeliness of diagnostic electromyography and nerve conduction study for carpel tunnel syndrome and peripheral neuropathy patients to avoid significant treatment delay and potential complications. We identified causes of delayed appointments and implemented strategies to reduce it from 12 to 2 weeks...
2016: Studies in Health Technology and Informatics
Jacob E Munro, Elissa F Liew, Mai-Anh Ly, Nicholas V Coleman
UNLABELLED: 1,2-Dichloroethane (DCA) is a problematic xenobiotic groundwater pollutant. Bacteria are capable of biodegrading DCA, but the evolution of such bacteria is not well understood. In particular, the mechanisms by which bacteria acquire the key dehalogenase genes dhlA and dhlB have not been well defined. In this study, the genomic context of dhlA and dhlB was determined in three aerobic DCA-degrading bacteria (Starkeya novella strain EL1, Xanthobacter autotrophicus strain EL4, and Xanthobacter flavus strain EL8) isolated from a groundwater treatment plant (GTP)...
September 1, 2016: Applied and Environmental Microbiology
Bohyun Kim, Seung Soo Lee, Yu Sub Sung, Hyunhee Cheong, Jae Ho Byun, Hyoung Jung Kim, Jin Hee Kim
PURPOSE: To evaluate the diagnostic value of apparent diffusion coefficient (ADC) and intravoxel incoherent motion (IVIM) parameters in differentiating patients with either a normal pancreas (NP), pancreatic ductal adenocarcinoma (PDAC), neuroendocrine tumor (NET), solid pseudopapillary tumor (SPT), acute pancreatitis (AcP), vs. autoimmune pancreatitis (AIP). MATERIALS AND METHODS: In all, 84 pathologically confirmed pancreatic tumors (60 PDACs, 15 NETs, 9 SPTs), 20 pancreatitis (13 AcPs, 7 AIPs), and 30 NP subjects underwent IVIM diffusion-weighted imaging using 10 b-values (0-900 sec/mm(2) ) at 1...
January 2017: Journal of Magnetic Resonance Imaging: JMRI
Gözde Aydoğdu Tığ, Bülent Zeybek, Şule Pekyardımcı
In this study, a simple methodology was used to develop a new electrochemical DNA biosensor based on poly(2,6-pyridinedicarboxylic acid) (P(PDCA)) modified glassy carbon electrode (GCE). This modified electrode was used to monitor for the electrochemical interaction between the dsDNA and gemcitabine (GEM) for the first time. A decrease in oxidation signals of guanine after the interaction of the dsDNA with the GEM was used as an indicator for the selective determination of the GEM via differential pulse voltammetry (DPV)...
July 1, 2016: Talanta
Zhaoyang Ma, Guangming Liu, Manli Zhang, Man Li, Yuanyuan Liu, Jiang Yanfang
BACKGROUND AND AIMS: As a newly discovered B-cell subset, PDCA-1(+) B cells have been shown to participate in the immune clearance of invading pathogens. The prominence of PDCA-1(+) B cell immunity in the pathogenesis of Helicobacter pylori infection prompted us to explore the potential role of this subset in gastric H. pylori infection. METHODS: H. pylori infection was determined by (14)C-urea breath test and Western blot. The frequency of the different sub-compartments of PDCA-1(+) B cells and their relation to serum cytokines was determined in 33 H...
February 2016: Archives of Medical Research
H Tang, R R Zhang
No abstract text is available yet for this article.
April 8, 2016: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
Jens Niederhausen, Heath R Kersell, Christos Christodoulou, Georg Heimel, Henrike Wonneberger, Klaus Müllen, Jürgen P Rabe, Saw-Wai Hla, Norbert Koch
9-(Bis-p-tert-octylphenyl)-amino-perylene-3,4-dicarboxy anhydride (BOPA-PDCA) is a strongly dipolar molecule representing a group of asymmetrically substituted perylenes that are employed in dye-sensitized solar cells and hold great promise for discotic liquid crystal applications. Thin BOPA-PDCA films with orientated dipole moments can potentially be used to tune the energy-level alignment in electronic devices and store information. To help assessing these prospects, we here elucidate the molecular self-assembly and electronic structure of BOPA-PCDA employing room temperature scanning tunneling microscopy and spectroscopy in combination with ultraviolet and X-ray photoelectron spectroscopies...
April 19, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
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