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https://www.readbyqxmd.com/read/29551697/comprehensive-multicenter-graduate-surgical-education-initiative-incorporating-entrustable-professional-activities-continuous-quality-improvement-cycles-and-a-web-based-platform-to-enhance-teaching-and-learning
#1
Cheryl I Anderson, Marc D Basson, Muhammad Ali, Alan T Davis, Robert L Osmer, Michael K McLeod, Pam S Haan, Robert G Molnar, Andi N Peshkepija, John C Hardaway, Karen A Chojnacki, Christopher C Pfeifer, Jeffrey M Gauvin, Mark W Jones, M Ashraf Mansour
BACKGROUND: It is increasingly important for faculty to teach deliberately and provide timely, detailed and formative feedback on surgical trainee performance. We initiated a multicenter study to improve resident evaluative processes and enhance teaching and learning behaviors while engaging residents in their education. METHODS: Faculty from seven U.S. postgraduate training programs rated resident operative performances using the perioperative briefing, intraoperative teaching, debriefing model (BID) and rated patient visits/academic performances using the entrustable professional activities (EPAs) model via a web-based platform...
March 15, 2018: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29496552/identification-of-a-tyrosinase-gene-and-its-functional-analysis-in-melanin-synthesis-of-pteria-penguin
#2
Feifei Yu, Zhenni Pan, Bingliang Qu, Xiangyong Yu, Kaihang Xu, Yuewen Deng, Feilong Liang
Tyrosinase is a key rate-limiting enzyme in melanin synthesis. In this study, a new tyrosinase gene (Tyr) was identified from Pteria penguin and its effect on melanin synthesis was deliberated by RNA interference (RNAi). The cDNA of PpTyr was 1728 bp long, containing a 5'untranslated region (UTR) of 11 bp, a 3'UTR of 295 bp, and an open reading fragment of 1422 bp encoding 473 amino acids. Amino acid alignment showed PpTyr had the highest (50%) identity to tyrosinase-like protein 1 from Pinctada fucata...
May 20, 2018: Gene
https://www.readbyqxmd.com/read/29459213/maximal-intensity-exercise-does-not-fully-restore-muscle-pyruvate-dehydrogenase-complex-activation-after-3-days-of-high-fat-dietary-intake
#3
D Constantin-Teodosiu, G Cederblad, M Bergström, P L Greenhaff
BACKGROUND & AIMS: Exercise activates muscle pyruvate dehydrogenase complex (PDC), but moderate intensity exercise fails to fully activate muscle PDC after high-fat diet [1]. We investigated whether maximal intensity exercise overcomes this inhibition. METHODS: Quadriceps femoris muscle biopsy samples were obtained from healthy males at rest, and after 46 and 92 electrically-evoked maximal intermittent isometric contractions, which were preceded by 3 days of either low- (18%) or high- (69%) isocaloric dietary fat intake (LFD and HFD, respectively)...
February 15, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29441347/pyridine-2-4-dicarboxylic-acid-suppresses-tomato-seedling-growth
#4
Sotirios Fragkostefanakis, Dimitrios Kaloudas, Panagiotis Kalaitzis
Pyridine 2,4-dicarboxylic acid is a structural analog of 2-oxoglutarate and is known to inhibit 2-oxoglutare-dependent dioxygenases. The effect of this inhibitor in tomato seedlings grown in MS media supplied with various concentrations of PDCA was investigated, resulting in shorter roots and hypocotyls in a dose-dependent manner. The partial inhibition of growth in roots was more drastic compared to hypocotyls and was attributed to a decrease in the elongation of root and hypocotyl cells. Concentrations of 100 and 250 μM of PDCA decreased hydroxyproline content in roots while only the 250 μM treatment reduced the hydroxyproline content in shoots...
2018: Frontiers in Chemistry
https://www.readbyqxmd.com/read/29239017/five-key-lncrnas-considered-as-prognostic-targets-for-predicting-pancreatic-ductal-adenocarcinoma
#5
Jukun Song, Qiuyan Xu, Haodeng Zhang, Xinhai Yin, Chen Zhu, Ke Zhao, Jianguo Zhu
Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis, and the 5-year survival rate was only 7.7%. To improve prognosis, a screening biomarker for early diagnosis of pancreatic cancer is in urgent need. Long non-coding RNA (lncRNA) expression profiles as potential cancer prognostic biomarkers play critical roles in development of tumorigenesis and metastasis of cancer. However, lncRNA signatures in predicting the survival of a patient with PDAC remain unknown. In the current study, we try to identify potential lncRNA biomarkers and their prognostic values in PDAC...
December 13, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29075619/modulating-the-global-response-regulator-luxo-of-v-cholerae-quorum-sensing-system-using-a-pyrazine-dicarboxylic-acid-derivative-pdca-py-an-antivirulence-approach
#6
M Hema, Sahana Vasudevan, P Balamurugan, S Adline Princy
Vibrio cholerae is a Gram-negative pathogen which causes acute diarrhoeal disease, cholera by the expression of virulence genes through quorum sensing (QS) mechanism. The QS circuit of V. cholerae is controlled by the global quorum regulator, LuxO, which at low cell density (LCD) state produces major virulence factors such as, toxin co-regulated pilus (TCP) and cholera toxin (CT) to mediate infection. On the contrary, at the high cell density (HCD) state the virulent genes are downregulated and the vibrios are detached from the host intestinal epithelial cells, promoted by HapA protease...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28975495/evaluation-of-tumor-morphologies-and-association-with-biochemical-recurrence-after-radical-prostatectomy-in-grade-group-5-prostate-cancer
#7
Trevor A Flood, Nicola Schieda, Jordan Sim, Rodney H Breau, Chris Morash, Eric C Belanger, Susan J Robertson
We assessed Gleason pattern 5 (GP5) and other prostatic adenocarcinoma (PCa) morphologies to determine their association with biochemical recurrence (BCR). A search for grade group 5 PCa with radical prostatectomy (RP) yielded 49 patients. RPs were reviewed for %GP5 and morphologies (sheets, single cells, cords, small solid cylinders, solid medium to large nests with rosette-like spaces [SMLNRS], comedonecrosis, cribriform glands, glomerulations, intraductal carcinoma of the prostate [IDC-P], and prostatic ductal adenocarcinoma [PDCa])...
February 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28882948/runx3-as-a-potential-predictor-of-metastasis-in-human-pancreatic-cancer
#8
Ernesto Rossi, Cinzia Bagalà, Frediano Inzani, Emanuele Leoncini, Chiara Brunelli, Paola Lanza, Michele Basso, Gian Carlo Mattiucci, Alessandra Cassano, Guido Rindi, Carlo Barone, Giovanni Schinzari
BACKGROUND/AIM: In genetically engineered murine models of pancreatic ductal adenocarcinomas (PDAC), high levels of Runx3 increase the metastatic potential of cancer cells. In this study we evaluated the role of Runx3 in human pancreatic cancer. MATERIALS AND METHODS: Runx3 was retrospectively assessed by immunohistochemistry in seventy-eight tumor samples of patients who underwent surgical resection for PDCA and were followed at least for 24 months. RESULTS: Thirty-two cases resulted completely negative for Runx3; forty-six showed highly variable expression...
September 2017: In Vivo
https://www.readbyqxmd.com/read/28803603/prognostic-impact-of-cell-division-cycle-associated-2-expression-on-pancreatic-ductal-adenocarcinoma
#9
Meng-Yi Wang, Zhe-Yu Niu, Xiang-Gao Gao, Li Zhou, Quan Liao, Yu-Pei Zhao
Objective To examine the expression of cell division cycle associated 2 (CDCA 2) in pancreatic ductal adenocarcinoma (PDAC) and investigate its role in prognosis of PDAC patients. Methods This retrospective study included 155 PDAC patients who underwent surgical treatment and complete post-operative follow-up. Clinicopathologic data were collected through clinical database. Tissue microarray was constructed and immunohistochemistry was performed to detect CDCA2 expression in the PDAC tumor tissues and adjacent non-tumor tissues...
September 20, 2016: Chinese Medical Sciences Journal, Chung-kuo i Hsüeh K'o Hsüeh Tsa Chih
https://www.readbyqxmd.com/read/28652311/a-nutrient-regulated-cyclic-diguanylate-phosphodiesterase-controls-clostridium-difficile-biofilm-and-toxin-production-during-stationary-phase
#10
Erin B Purcell, Robert W McKee, David S Courson, Elizabeth M Garrett, Shonna M McBride, Richard E Cheney, Rita Tamayo
The signaling molecule cyclic diguanylate (c-di-GMP) mediates physiological adaptation to extracellular stimuli in a wide range of bacteria. The complex metabolic pathways governing c-di-GMP synthesis and degradation are highly regulated, but the specific cues that impact c-di-GMP signaling are largely unknown. In the intestinal pathogen Clostridium difficile , c-di-GMP inhibits flagellar motility and toxin production and promotes pilus-dependent biofilm formation, but no specific biological functions have been ascribed to any of the individual c-di-GMP synthases or phosphodiesterases (PDEs)...
September 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28640564/-design-and-user-testing-of-a-decision-aid-comparing-medications-for-smoking-cessation
#11
Julian Jakob, Jacques Cornuz, Reto Auer, Isabelle Jacot Sadowski, Regula Cardinaux, Kevin Selby
Medications for smoking cessation, such as nicotine replacement, bupropion and varenicline have comparable efficacy, but present different advantages and drawbacks, making patient-specific preferences important when choosing a medication for smoking cessation. Through 3 PDCA cycles (Plan-Do-Check-Act), we developed and user-tested a decision aid for use during consultations. It contains the most relevant information for choosing a smoking cessation medication and is freely available online. The methodology used for its development could be employed for other decision aids for preference-sensitive decisions...
June 7, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28424879/drinking-water-management-and-governance-in-canada-an-innovative-plan-do-check-act-pdca-framework-for-a-safe-drinking-water-supply
#12
Ty Bereskie, Manuel J Rodriguez, Rehan Sadiq
Drinking water management in Canada is complex, with a decentralized, three-tiered governance structure responsible for safe drinking water throughout the country. The current approach has been described as fragmented, leading to governance gaps, duplication of efforts, and an absence of accountability and enforcement. Although there have been no major waterborne disease outbreaks in Canada since 2001, a lack of performance improvement, especially in small drinking water systems, is evident. The World Health Organization water safety plan approach for drinking water management represents an alternative preventative management framework to the current conventional, reactive drinking water management strategies...
August 2017: Environmental Management
https://www.readbyqxmd.com/read/28159977/parapapillary-diffuse-choroidal-atrophy-in-children-is-associated-with-extreme-thinning-of-parapapillary-choroid
#13
Tae Yokoi, Dan Zhu, Hong Sheng Bi, Jost B Jonas, Rahul A Jonas, Natsuko Nagaoka, Muka Moriyama, Takeshi Yoshida, Kyoko Ohno-Matsui
Purpose: To analyze morphologic features of segmental parapapillary diffuse choroidal atrophy (PDCA) in children. Methods: The study group included children (age ≤15 years) with high myopia who attended the Tokyo High Myopia Clinic. Control groups comprised participants of the population-based Gobi Desert Children Eye Study (GobiDCES). Fundus photographs were examined for presence of PDCA and choroidal thickness (CT) was measured by optical coherence tomography...
February 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28152961/banning-the-use-of-intracorporeal-morcellation
#14
Stephen F Rechner, Douglas M VanDrie, Ralph N Rogers
132 Background: In response to the FDA safety communication we banned the use of intracorporeal morcellation effective April 22(nd) 2014. Clinicians expressed frustration and a concern that an increase in the abdominal hysterectomy rate or percentage, wound complications, and length of stay would occur. Our PDCA (plan, do, check, and act) safety process reviewed these quality and safety metrics one year later. METHODS: This is a retrospective evaluation of a prospective institutional decision...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28047333/su-f-t-245-the-investigation-of-failure-mode-and-effects-analysis-and-pdca-for-the-radiotherapy-risk-reduction
#15
J Xie, J Wang, J P, J Chen, W Hu
PURPOSE: To optimize the clinical processes of radiotherapy and to reduce the radiotherapy risks by implementing the powerful risk management tools of failure mode and effects analysis(FMEA) and PDCA(plan-do-check-act). METHODS: A multidiciplinary QA(Quality Assurance) team from our department consisting of oncologists, physicists, dosimetrists, therapists and administrator was established and an entire workflow QA process management using FMEA and PDCA tools was implemented for the whole treatment process...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27933158/development-and-implementation-of-a-standardized-pathway-in-the-pediatric-intensive-care-unit-for-children-with-severe-traumatic-brain-injuries
#16
Lauren Rakes, Mary King, Brian Johnston, Randall Chesnut, Rosemary Grant, Monica Vavilala
Severe traumatic brain injury (TBI) is a leading cause of morbidity and mortality in children. In 2003 and 2012, the Brain Trauma Foundation established and refined evidence-based guidelines for management of severe TBI in children. A recent multicenter study demonstrated an association between TBI guideline adherence and improved discharge survival. However, this study also showed large variation in adherence to pediatric TBI management at our level 1 pediatric trauma center, where overall adherence to fourteen pediatric intensive care unit (PICU) TBI clinical indicators was 64%...
2016: BMJ Quality Improvement Reports
https://www.readbyqxmd.com/read/27858081/-the-improvement-of-periodontal-teaching-mode-based-on-pdca-theory
#17
Hong-Yan Wang, Ling-Na Han, Xiao-Hua Zhu, Hong-Mei Ma, Ya-Ping Pan
PURPOSE: To evaluate the effect of PDCA teaching mode on clinical ability in the process of periodontal clinical internship. METHODS: Forty-eight undergraduate interns coming from School of Stomatology, China Medical University were divided into 2 groups, one group received traditional teaching mode, the other group received a teaching mode based on PDCA cycle. At the end of internship, every student was assessed by theoretical examinations, case reports and clinical skill practice...
August 2016: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/27733221/prognostic-impact-of-cell-division-cycle-associated-2-expression-on-pancreatic-ductal-adenocarcinoma
#18
Meng-Yi Wang, Zhe-Yu Niu, Xiang-Gao Gao, Li Zhou, Quan Liao, Yu-Pei Zhao
<strong>Objective</strong> To examine the expression of cell division cycle associated 2 (CDCA 2) in pancreatic ductal adenocarcinoma (PDAC) and investigate its role in prognosis of PDAC patients. <strong>Methods</strong> This retrospective study included 155 PDAC patients who underwent surgical treatment and complete post-operative follow-up. Clinicopathologic data were collected through clinical database. Tissue microarray was constructed and immunohistochemistry was performed to detect CDCA2 expression in the PDAC tumor tissues and adjacent non-tumor tissues...
September 20, 2016: Chinese Medical Sciences Journal, Chung-kuo i Hsüeh K'o Hsüeh Tsa Chih
https://www.readbyqxmd.com/read/27676757/sensory-information-treatment-during-disturbed-standing-posture-in-chronic-acquired-demyelinating-polyneuropathies-cadp
#19
Clément Provost, Giulia Piccinini, Sophie Tasseel-Ponche, Pierre Lozeron, Bertrand Arnulf, Alain Yelnik
OBJECTIVE: As proposed after stroke, the study of reactions to a sensory stimulation allows to a better understanding of postural strategies. Below, we provide the analysis in chronic acquired demyelinating polyneuropathies (CADP). MATERIAL/PATIENTS AND METHODS: Prospective study of 25 healthy subjects (57±12years, 8M, 17F) and 25 CADP (66±14years, 20M, 5F) on stabilometric platform (Techno-Concept(®), France). Proprioception was disturbed by tendon vibration on Triceps Surae (TS) and Tibialis Anterior (TA)...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27665192/2-3-pyridine-dicarboxylic-acid-functionalized-gold-nanoparticles-insight-into-experimental-conditions-for-cr-3-sensing
#20
Ruqaya Shaikh, Najma Memon, Amber R Solangi, Huma I Shaikh, Muhammad Hassan Agheem, Syed Abid Ali, Muhammad Raza Shah, Aftab Kandhro
Selectivity of gold nanoparticles (AuNPs) depends upon surface functionality; small changes in structure or concentration bring significant changes in the behavior of AuNPs. In this study, citrate-capped AuNPs were functionalized with ortho-dicarboxylate substituted pyridine (2,3-PDCA) and detailed studies on experimental conditions were carried out to check the stability of AuNPs and response for Cr3+ . Stability of PDCA-AuNPs was found sensitive to the pH, ionic strength of buffer and its type. Capping behavior of PDCA on C-AuNPs was examined by FTIR spectroscopy...
February 15, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
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