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https://www.readbyqxmd.com/read/29075619/modulating-the-global-response-regulator-luxo-of-v-cholerae-quorum-sensing-system-using-a-pyrazine-dicarboxylic-acid-derivative-pdca-py-an-antivirulence-approach
#1
M Hema, Sahana Vasudevan, P Balamurugan, S Adline Princy
Vibrio cholerae is a Gram-negative pathogen which causes acute diarrhoeal disease, cholera by the expression of virulence genes through quorum sensing (QS) mechanism. The QS circuit of V. cholerae is controlled by the global quorum regulator, LuxO, which at low cell density (LCD) state produces major virulence factors such as, toxin co-regulated pilus (TCP) and cholera toxin (CT) to mediate infection. On the contrary, at the high cell density (HCD) state the virulent genes are downregulated and the vibrios are detached from the host intestinal epithelial cells, promoted by HapA protease...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28975495/evaluation-of-tumor-morphologies-and-association-with-biochemical-recurrence-after-radical-prostatectomy-in-grade-group-5-prostate-cancer
#2
Trevor A Flood, Nicola Schieda, Jordan Sim, Rodney H Breau, Chris Morash, Eric C Belanger, Susan J Robertson
We assessed Gleason pattern 5 (GP5) and other prostatic adenocarcinoma (PCa) morphologies to determine their association with biochemical recurrence (BCR). A search for grade group 5 PCa with radical prostatectomy (RP) yielded 49 patients. RPs were reviewed for %GP5 and morphologies (sheets, single cells, cords, small solid cylinders, solid medium to large nests with rosette-like spaces [SMLNRS], comedonecrosis, cribriform glands, glomerulations, intraductal carcinoma of the prostate [IDC-P], and prostatic ductal adenocarcinoma [PDCa])...
October 3, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28882948/runx3-as-a-potential-predictor-of-metastasis-in-human-pancreatic-cancer
#3
Ernesto Rossi, Cinzia Bagalà, Frediano Inzani, Emanuele Leoncini, Chiara Brunelli, Paola Lanza, Michele Basso, Gian Carlo Mattiucci, Alessandra Cassano, Guido Rindi, Carlo Barone, Giovanni Schinzari
BACKGROUND/AIM: In genetically engineered murine models of pancreatic ductal adenocarcinomas (PDAC), high levels of Runx3 increase the metastatic potential of cancer cells. In this study we evaluated the role of Runx3 in human pancreatic cancer. MATERIALS AND METHODS: Runx3 was retrospectively assessed by immunohistochemistry in seventy-eight tumor samples of patients who underwent surgical resection for PDCA and were followed at least for 24 months. RESULTS: Thirty-two cases resulted completely negative for Runx3; forty-six showed highly variable expression...
September 2017: In Vivo
https://www.readbyqxmd.com/read/28803603/prognostic-impact-of-cell-division-cycle-associated-2-expression-on-pancreatic-ductal-adenocarcinoma
#4
Meng-Yi Wang, Zhe-Yu Niu, Xiang-Gao Gao, Li Zhou, Quan Liao, Yu-Pei Zhao
Objective To examine the expression of cell division cycle associated 2 (CDCA 2) in pancreatic ductal adenocarcinoma (PDAC) and investigate its role in prognosis of PDAC patients. Methods This retrospective study included 155 PDAC patients who underwent surgical treatment and complete post-operative follow-up. Clinicopathologic data were collected through clinical database. Tissue microarray was constructed and immunohistochemistry was performed to detect CDCA2 expression in the PDAC tumor tissues and adjacent non-tumor tissues...
September 20, 2016: Chinese Medical Sciences Journal, Chung-kuo i Hsüeh K'o Hsüeh Tsa Chih
https://www.readbyqxmd.com/read/28652311/a-nutrient-regulated-cyclic-diguanylate-phosphodiesterase-controls-clostridium-difficile-biofilm-and-toxin-production-during-stationary-phase
#5
Erin B Purcell, Robert W McKee, David S Courson, Elizabeth M Garrett, Shonna M McBride, Richard E Cheney, Rita Tamayo
The signaling molecule cyclic diguanylate (c-di-GMP) mediates physiological adaptation to extracellular stimuli in a wide range of bacteria. The complex metabolic pathways governing c-di-GMP synthesis and degradation are highly regulated, but the specific cues that impact c-di-GMP signaling are largely unknown. In the intestinal pathogen Clostridium difficile, c-di-GMP inhibits flagellar motility and toxin production and promotes pilus-dependent biofilm formation, but no specific biological functions have been ascribed to any of the individual c-di-GMP synthases or phosphodiesterases (PDEs)...
September 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28640564/-design-and-user-testing-of-a-decision-aid-comparing-medications-for-smoking-cessation
#6
Julian Jakob, Jacques Cornuz, Reto Auer, Isabelle Jacot Sadowski, Regula Cardinaux, Kevin Selby
Medications for smoking cessation, such as nicotine replacement, bupropion and varenicline have comparable efficacy, but present different advantages and drawbacks, making patient-specific preferences important when choosing a medication for smoking cessation. Through 3 PDCA cycles (Plan-Do-Check-Act), we developed and user-tested a decision aid for use during consultations. It contains the most relevant information for choosing a smoking cessation medication and is freely available online. The methodology used for its development could be employed for other decision aids for preference-sensitive decisions...
June 7, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28424879/drinking-water-management-and-governance-in-canada-an-innovative-plan-do-check-act-pdca-framework-for-a-safe-drinking-water-supply
#7
Ty Bereskie, Manuel J Rodriguez, Rehan Sadiq
Drinking water management in Canada is complex, with a decentralized, three-tiered governance structure responsible for safe drinking water throughout the country. The current approach has been described as fragmented, leading to governance gaps, duplication of efforts, and an absence of accountability and enforcement. Although there have been no major waterborne disease outbreaks in Canada since 2001, a lack of performance improvement, especially in small drinking water systems, is evident. The World Health Organization water safety plan approach for drinking water management represents an alternative preventative management framework to the current conventional, reactive drinking water management strategies...
August 2017: Environmental Management
https://www.readbyqxmd.com/read/28159977/parapapillary-diffuse-choroidal-atrophy-in-children-is-associated-with-extreme-thinning-of-parapapillary-choroid
#8
Tae Yokoi, Dan Zhu, Hong Sheng Bi, Jost B Jonas, Rahul A Jonas, Natsuko Nagaoka, Muka Moriyama, Takeshi Yoshida, Kyoko Ohno-Matsui
Purpose: To analyze morphologic features of segmental parapapillary diffuse choroidal atrophy (PDCA) in children. Methods: The study group included children (age ≤15 years) with high myopia who attended the Tokyo High Myopia Clinic. Control groups comprised participants of the population-based Gobi Desert Children Eye Study (GobiDCES). Fundus photographs were examined for presence of PDCA and choroidal thickness (CT) was measured by optical coherence tomography...
February 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28152961/banning-the-use-of-intracorporeal-morcellation
#9
Stephen F Rechner, Douglas M VanDrie, Ralph N Rogers
132 Background: In response to the FDA safety communication we banned the use of intracorporeal morcellation effective April 22(nd) 2014. Clinicians expressed frustration and a concern that an increase in the abdominal hysterectomy rate or percentage, wound complications, and length of stay would occur. Our PDCA (plan, do, check, and act) safety process reviewed these quality and safety metrics one year later. METHODS: This is a retrospective evaluation of a prospective institutional decision...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28047333/su-f-t-245-the-investigation-of-failure-mode-and-effects-analysis-and-pdca-for-the-radiotherapy-risk-reduction
#10
J Xie, J Wang, J P, J Chen, W Hu
PURPOSE: To optimize the clinical processes of radiotherapy and to reduce the radiotherapy risks by implementing the powerful risk management tools of failure mode and effects analysis(FMEA) and PDCA(plan-do-check-act). METHODS: A multidiciplinary QA(Quality Assurance) team from our department consisting of oncologists, physicists, dosimetrists, therapists and administrator was established and an entire workflow QA process management using FMEA and PDCA tools was implemented for the whole treatment process...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27933158/development-and-implementation-of-a-standardized-pathway-in-the-pediatric-intensive-care-unit-for-children-with-severe-traumatic-brain-injuries
#11
Lauren Rakes, Mary King, Brian Johnston, Randall Chesnut, Rosemary Grant, Monica Vavilala
Severe traumatic brain injury (TBI) is a leading cause of morbidity and mortality in children. In 2003 and 2012, the Brain Trauma Foundation established and refined evidence-based guidelines for management of severe TBI in children. A recent multicenter study demonstrated an association between TBI guideline adherence and improved discharge survival. However, this study also showed large variation in adherence to pediatric TBI management at our level 1 pediatric trauma center, where overall adherence to fourteen pediatric intensive care unit (PICU) TBI clinical indicators was 64%...
2016: BMJ Quality Improvement Reports
https://www.readbyqxmd.com/read/27858081/-the-improvement-of-periodontal-teaching-mode-based-on-pdca-theory
#12
Hong-Yan Wang, Ling-Na Han, Xiao-Hua Zhu, Hong-Mei Ma, Ya-Ping Pan
PURPOSE: To evaluate the effect of PDCA teaching mode on clinical ability in the process of periodontal clinical internship. METHODS: Forty-eight undergraduate interns coming from School of Stomatology, China Medical University were divided into 2 groups, one group received traditional teaching mode, the other group received a teaching mode based on PDCA cycle. At the end of internship, every student was assessed by theoretical examinations, case reports and clinical skill practice...
August 2016: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/27733221/prognostic-impact-of-cell-division-cycle-associated-2-expression-on-pancreatic-ductal-adenocarcinoma
#13
Meng-Yi Wang, Zhe-Yu Niu, Xiang-Gao Gao, Li Zhou, Quan Liao, Yu-Pei Zhao
<strong>Objective</strong> To examine the expression of cell division cycle associated 2 (CDCA 2) in pancreatic ductal adenocarcinoma (PDAC) and investigate its role in prognosis of PDAC patients. <strong>Methods</strong> This retrospective study included 155 PDAC patients who underwent surgical treatment and complete post-operative follow-up. Clinicopathologic data were collected through clinical database. Tissue microarray was constructed and immunohistochemistry was performed to detect CDCA2 expression in the PDAC tumor tissues and adjacent non-tumor tissues...
September 20, 2016: Chinese Medical Sciences Journal, Chung-kuo i Hsüeh K'o Hsüeh Tsa Chih
https://www.readbyqxmd.com/read/27676757/sensory-information-treatment-during-disturbed-standing-posture-in-chronic-acquired-demyelinating-polyneuropathies-cadp
#14
Clément Provost, Giulia Piccinini, Sophie Tasseel-Ponche, Pierre Lozeron, Bertrand Arnulf, Alain Yelnik
OBJECTIVE: As proposed after stroke, the study of reactions to a sensory stimulation allows to a better understanding of postural strategies. Below, we provide the analysis in chronic acquired demyelinating polyneuropathies (CADP). MATERIAL/PATIENTS AND METHODS: Prospective study of 25 healthy subjects (57±12years, 8M, 17F) and 25 CADP (66±14years, 20M, 5F) on stabilometric platform (Techno-Concept(®), France). Proprioception was disturbed by tendon vibration on Triceps Surae (TS) and Tibialis Anterior (TA)...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27665192/2-3-pyridine-dicarboxylic-acid-functionalized-gold-nanoparticles-insight-into-experimental-conditions-for-cr-3-sensing
#15
Ruqaya Shaikh, Najma Memon, Amber R Solangi, Huma I Shaikh, Muhammad Hassan Agheem, Syed Abid Ali, Muhammad Raza Shah, Aftab Kandhro
Selectivity of gold nanoparticles (AuNPs) depends upon surface functionality; small changes in structure or concentration bring significant changes in the behavior of AuNPs. In this study, citrate-capped AuNPs were functionalized with ortho-dicarboxylate substituted pyridine (2,3-PDCA) and detailed studies on experimental conditions were carried out to check the stability of AuNPs and response for Cr(3+). Stability of PDCA-AuNPs was found sensitive to the pH, ionic strength of buffer and its type. Capping behavior of PDCA on C-AuNPs was examined by FTIR spectroscopy...
February 15, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/27610698/reducing-variability-in-orthogonal-reformatted-image-quality-associated-with-axial-long-z-axis-ct-angiography
#16
Erica B Stein, Peter S Liu, Ella A Kazerooni, Karen Barber, Matthew S Davenport
OBJECTIVE: The objective of our study was to reduce variation in image quality of orthogonal reformatted images generated from long-z-axis CT angiography (CTA) studies of the upper and lower extremities. SUBJECTS AND METHODS: Upper and lower extremity CTA studies were targeted at a single health care system. A correctly performed CTA examination was defined as one that met the following three criteria: Sagittal and coronal reformats were obtained, a high-resolution matrix greater than 512 × 512 was used, and reformatted images were available in a distance-measurable format...
December 2016: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/27494847/preoperative-neutrophil-to-lymphocyte-ratio-and-tumor-related-factors-to-predict-lymph-node-metastasis-in-patients-with-pancreatic-ductal-adenocarcinoma-pdac
#17
Lianyuan Tao, Lingfu Zhang, Ying Peng, Ming Tao, Gang Li, Dianrong Xiu, Chunhui Yuan, Chaolai Ma, Bin Jiang
As a poor prognosis indicator in patients with pancreatic ductal adenocarcinoma (PDCA), lymph node (LN) metastasis is of great importance in treatment. Present study was performed to evaluate the predictive value of preoperative neutrophil-to-lymphocyte ratio (NLR), Platelet-to-lymphocyte ratio (PLR) and possible clinical parameters on the LN metastasis in PDCA patients. A total of 159 operable patients with PDCA were enrolled in our study. The clinical utility of NLR and other clinical parameters was evaluated by receiver operating characteristic (ROC) curves...
November 8, 2016: Oncotarget
https://www.readbyqxmd.com/read/27424525/african-americans-with-pancreatic-ductal-adenocarcinoma-exhibit-gender-differences-in-kaiso-expression
#18
MULTICENTER STUDY
Jacqueline Jones, Angana Mukherjee, Balasubramanyam Karanam, Melissa Davis, Jesse Jaynes, R Renee Reams, Windy Dean-Colomb, Clayton Yates
Kaiso, a bi-modal transcription factor, regulates gene expression, and is elevated in breast, prostate, and colon cancers. Depletion of Kaiso in other cancer types leads to a reduction in markers for the epithelial-mesenchymal transition (EMT) (Jones et al., 2014), however its clinical implications in pancreatic ductal adenocarcinoma (PDCA) have not been widely explored. PDCA is rarely detected at an early stage but is characterized by rapid progression and invasiveness. We now report the significance of the subcellular localization of Kaiso in PDCAs from African Americans...
October 1, 2016: Cancer Letters
https://www.readbyqxmd.com/read/27350505/improving-reports-turnaround-time-an-essential-healthcare-quality-dimension
#19
Mustafa Khan, Parwaiz Khalid, Youssef Al-Said, Edward Cupler, Lamia Almorsy, Mohamed Khalifa
Turnaround time is one of the most important healthcare performance indicators. King Faisal Specialist Hospital and Research Center in Jeddah, Saudi Arabia worked on reducing the reports turnaround time of the neurophysiology lab from more than two weeks to only five working days for 90% of cases. The main quality improvement methodology used was the FOCUS PDCA. Using root cause analysis, Pareto analysis and qualitative survey methods, the main factors contributing to the delay of turnaround time and the suggested improvement strategies were identified and implemented, through restructuring transcriptionists daily tasks, rescheduling physicians time and alerting for new reports, engaging consultants, consistent coordination and prioritizing critical reports...
2016: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/27350499/improving-timeliness-of-diagnostic-healthcare-services-effective-strategies-and-recommendations
#20
Mustafa Khan, Parwaiz Khalid, Lamia Almorsy, Mohamed Khalifa
Timeliness and accessibility of healthcare services reflect system's capacity to provide care quickly after a need is recognized. King Faisal Specialist Hospital and Research Center in Jeddah, Saudi Arabia worked on improving timeliness of diagnostic electromyography and nerve conduction study for carpel tunnel syndrome and peripheral neuropathy patients to avoid significant treatment delay and potential complications. We identified causes of delayed appointments and implemented strategies to reduce it from 12 to 2 weeks...
2016: Studies in Health Technology and Informatics
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