keyword
https://read.qxmd.com/read/38512406/predicting-pathological-complete-response-to-neoadjuvant-chemotherapy-in-breast-cancer-patients-use-of-mri-radiomics-data-from-three-regions-with-multiple-machine-learning-algorithms
#1
JOURNAL ARTICLE
Guangying Zheng, Jiaxuan Peng, Zhenyu Shu, Hui Jin, Lu Han, Zhongyu Yuan, Xue Qin, Jie Hou, Xiaodong He, Xiangyang Gong
OBJECTIVE: To construct a multi-region MRI radiomics model for predicting pathological complete response (pCR) in breast cancer (BCa) patients who received neoadjuvant chemotherapy (NACT) and provide a theoretical basis for the peritumoral microenvironment affecting the efficacy of NACT. METHODS: A total of 133 BCa patients who received NACT, including 49 with confirmed pCR, were retrospectively analyzed. The radiomics features of the intratumoral region, peritumoral region, and background parenchymal enhancement (BPE) were extracted, and the most relevant features were obtained after dimensional reduction...
March 21, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38496028/six-sigma-evaluation-of-17-biochemistry-parameters-using-bias-calculated-from-internal-quality-control-and-external-quality-assurance-data
#2
JOURNAL ARTICLE
Tülay Çevlik, Goncagül Haklar
BACKGROUND: Six Sigma is a popular quality management system that enables continuous monitoring and improvement of analytical performance in the clinical laboratory. We aimed to calculate sigma metrics and quality goal index (QGI) for 17 biochemical analytes and compare the use of bias from internal quality control (IQC) and external quality assurance (EQA) data in the calculation of sigma metrics. METHODS: This retrospective study was conducted in Marmara University Pendik E&R Hospital Biochemistry Laboratory...
January 25, 2024: Journal of Medical Biochemistry
https://read.qxmd.com/read/38476982/anticoagulation-stewardship-to-bridge-the-implementation-gap-in-perioperative-anticoagulation-management
#3
REVIEW
Alfonso J Tafur, Geoffrey D Barnes, Vinai C Bhagirath, James Douketis
Lack of alignment of care protocols among providers in health care is a driver of increased costs and suboptimal patient outcomes. Perioperative anticoagulation management is a good example of a complex area where protocol creation is a clinical challenge that demands input from multiple experts. Questions regarding the need for anticoagulation interruptions are frequent. Yet, due to layers of complexity involving analysis of anticoagulation indication, surgical risk, and anesthesia-associated bleeding risk as well as institutional practices, there is heterogeneity in how these interruptions are approached...
January 2024: TH Open: Companion Journal to Thrombosis and Haemostasis
https://read.qxmd.com/read/38457598/reducing-the-length-of-stay-for-patients-stranded-in-the-emergency-department-a-single-center-prospective-study-of-18-631-patients-in-china
#4
JOURNAL ARTICLE
Manman Shang, Guifang Zheng, Zhenyu Li, Qing Liu, Ling Lin, Yueping Li, Yong Wu, Qin Wei
The purpose of this study was to reduce the length of stay (LOS) for patients stranded in the emergency department (ED) of a Grade III A hospital in China, and to improve patient flow and increase bed capacity. We utilized a pre-/postintervention design and employed the Six Sigma methodology, which is based on the DMAIC cycle (define, measure, analyze, improve, and control), to evaluate and improve the existing process. Data from 18,631 patients who were stranded in the ED were collected and analyzed. The median LOS for stranded patients decreased from 17...
March 8, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38416920/improving-time-to-diagnostic-resolution-in-the-breast-imaging-service-a-tertiary-center-s-experience-and-process-of-improvement
#5
JOURNAL ARTICLE
Nader A Fawzy, Noor F AlMuslem, Afaf Altayeb, Mohammad J Ghosheh, Nuha A Khoumais
OBJECTIVE: Breast imaging services often experience a significant degree of variability in patient flow, leading to delay in time to diagnostic resolution, commonly referred to as time to resolution (TTR). This study applies Lean Six Sigma Methodology (LSSM) to reduce TTR and enhance patient outcomes. METHODS: This study was IRB-approved. A baseline audit was done using cases of mammographic recalls (BI-RADS 0) to measure baseline TTR. Multidisciplinary meetings with all members of the breast imaging service, alongside a study of patient complaint data, were utilized to identify issues that were causing prolonged TTR...
September 22, 2023: Journal of breast imaging
https://read.qxmd.com/read/38410055/comparison-of-power-spectra-from-overnight-electroencephalography-between-patients-with-down-syndrome-and-matched-control-subjects
#6
JOURNAL ARTICLE
Amlan Talukder, Deryck Yeung, Yuanyuan Li, Nishanth Anandanadarajah, David M Umbach, Zheng Fan, Leping Li
Electroencephalograms can capture brain oscillatory activities during sleep as a form of electrophysiological signals. We analysed electroencephalogram recordings from full-night in-laboratory polysomnography from 100 patients with Down syndrome, and 100 age- and sex-matched controls. The ages of patients with Down syndrome spanned 1 month to 31 years (median 4.4 years); 84 were younger than 12 years, and 54 were male. From each electroencephalogram, we extracted relative power in six frequency bands or rhythms (delta, theta, alpha, slow sigma, fast sigma, and beta) from six channels (frontal F3 and F4, central C3 and C4, and occipital O1 and O2) during five sleep stages (N3, N2, N1, R and W)-180 features in all...
February 27, 2024: Journal of Sleep Research
https://read.qxmd.com/read/38404460/improving-inpatient-medication-dispensing-with-an-automated-system
#7
JOURNAL ARTICLE
Afaf Almalki, Aseel Jambi, Basem Elbehiry, Hala Albuti
INTRODUCTION: Medication inventory management and error prevention are complex issues. Single interventions are insufficient to make improvement across the spectrum. A uniform system for dispensing and distributing medications can help reduce the risk of medication errors, improve efficiency, and minimize waste. This quality improvement project aims to: 1) decrease - the time from ordering medication to administration, including delay incidents, by > 70%; and 2) decrease the inpatient monthly total medication consumption by > 20% and ward medication stock items by > 70%, including decreasing returned items and loss from in-house expired medications by > 70%...
November 2023: Glob J Qual Saf Healthc
https://read.qxmd.com/read/38394423/analysis-of-hematology-quality-control-using-six-sigma-metrics
#8
JOURNAL ARTICLE
Shreya Goel, Amit R Nisal, Ankita Raj, Ravindra C Nimbargi
INTRODUCTION: Clinical laboratories serve a critical role in increasing the efficiency of patient care. Choosing the right test, getting trustworthy results and appropriate interpretation are of utmost importance in improving the patient's well-being. Quality management strategies should be applied in routine patient care because laboratory errors have a major impact on the quality of patient care. In sigma metrics, errors identified are quantified as percentage errors or defects per million (DPM)...
November 9, 2023: Indian Journal of Pathology & Microbiology
https://read.qxmd.com/read/38383764/saw-box-osteotomy-versus-reamer-box-osteotomy-in-posterior-stabilized-total-knee-arthroplasty-a-retrospective-study-of-an-average-five%C3%A2-year-follow-up
#9
JOURNAL ARTICLE
Ahmed Abdelbadie, Ahmed A Toreih, Moawed F El-Adawy, Mohamed S Arafa
PURPOSE: The purpose of this study is to compare the difference of results between two methods of femoral box osteotomy adopted by two designs of posterior stabilized total knee prostheses. PATIENTS AND METHODS: Retrospective analysis of the results of two groups of patients operated upon using two primary PS TKA systems, PFC Sigma (DePuy Synthes, Johnson and Johnson®) and Genesis II prosthesis (Smith and Nephew®), with an average of five year follow-up was done...
February 22, 2024: International Orthopaedics
https://read.qxmd.com/read/38380190/revolutionising-quality-management-in-the-oral-pathology-laboratory-a-deep-dive-into-the-six-sigma-methodology
#10
REVIEW
Neha Kannan, Karthikeyan Ramalingam, Pratibha Ramani
Six Sigma Foundations is a statistical standard that indicates an exceptionally high level of quality, along with a customer satisfaction management approach that intends to lower error rates and boost process efficiency. The Define, Measure, Analyse, Improve, and Control (DMAIC) approach is a fundamental component of Six Sigma and provides an organised framework for process improvement. In contrast to conventional techniques that are more manual-based, Six Sigma emphasises and focuses on making decisions based on facts and evidence...
January 2024: Curēus
https://read.qxmd.com/read/38379978/enhancing-performance-measurement-of-public-procurement-processes-through-the-application-of-procurement-delay-index
#11
JOURNAL ARTICLE
Jemima A Ottou, Bernard K Baiden, Gabriel Nani, Martin Morgan Tuuli
Considering procurement process performance assessment, measurement systems such as balance scorecard and capability maturity models are used to assess procurement performance to give a reasonable indication of actual performance. These tools are ideal for practical applications that depend on other performance criteria but are short of comparing planned to actual timelines set for procurement processes. This fosters persistent delays in public procurement. Six Sigma implementation benefits including addressing process delays have fostered its implementation for service improvements...
February 29, 2024: Heliyon
https://read.qxmd.com/read/38379081/hepatoprotective-effect-of-moringa-oil-on-rats-under-fungicide-toxicity
#12
JOURNAL ARTICLE
Khalid S Alotaibi, Daklallah A Almalki
The present study is designed to evaluate whether pretreatment with moringa would have a protective effect on thioacetamide (TAA)-induced liver fibrosis, assessing biochemical and histopathological changes in Wistar male rats. Exposure to TAA induced notable biochemical and histopathological alterations. Liver fibrosis induced by TAA, along with associated biochemical and histological damage, has not been previously investigated in male rats supplemented with moringa oil. The experiment involved forty male rats distributed across four groups, each comprising ten rats...
February 20, 2024: Doklady. Biochemistry and Biophysics
https://read.qxmd.com/read/38338177/lean-six-sigma-approach-to-improve-the-management-of-patients-undergoing-laparoscopic-cholecystectomy
#13
JOURNAL ARTICLE
Arianna Scala, Giovanni Improta
Laparoscopic cholecystectomy (LC) is the gold standard technique for gallbladder diseases in both emergency and elective surgery. The incidence of the disease related to an increasingly elderly population coupled with the efficacy and safety of LC treatment resulted in an increase in the frequency of interventions without an increase in surgical mortality. For these reasons, managers implement strategies by which to standardize the process of patients undergoing LC. Specifically, the goal is to ensure, in accordance with the guidelines of the Italian Ministry of Health, a reduction in post-operative length of stay (LOS)...
January 23, 2024: Healthcare (Basel, Switzerland)
https://read.qxmd.com/read/38319050/deciphering-induced-variability-character-association-and-multivariate-analysis-utilizing-gamma-rays-and-ethyl-methanesulfonate-in-bread-wheat-triticum-aestivum-l-genotypes-with-differential-grain-texture
#14
JOURNAL ARTICLE
Amit Rana, Vijay Rana, Suman Bakshi, Vinod Kumar Sood, Priyanka, Anuradha
PURPOSE: Sustainable wheat production and higher genetic gains can be realized by broadening the genetic base and improving the well adapted varieties. In the present study, a multi-year experiment involving induced mutagenesis was conducted to create genetic variation, assess trait associations and genetic divergence in four wheat varieties with differential grain texture treated with six doses of gamma rays and ethyl methane sulfonate using ten agro-morphological traits. MATERIALS AND METHODS: Healthy selfed seeds of four bread wheat varieties with differential texture were irradiated using six doses ranging from 175 Gy-300 Gy of gamma rays (Co60 : BARC, Mumbai) and six concentrations of ethyl methanesulfonate (0...
February 6, 2024: International Journal of Radiation Biology
https://read.qxmd.com/read/38292960/the-evaluation-of-the-quality-performance-of-biochemical-analytes-in-clinical-biochemistry-laboratory-using-six-sigma-matrices
#15
JOURNAL ARTICLE
Chhabi R Panda, Suchitra Kumari, Manaswini Mangaraj, Saurav Nayak
Introduction This study was conducted to assess the analytical performance of biochemical tests using Six Sigma methodology and to assess the underlying causes of unsatisfied performance of analytes with a sigma value of less than 4 using quality goal index (QGI) and root cause analysis (RCA). Methodology Daily data for internal quality control (IQC) for both level 1 (L1) and level 2 (L2) and monthly data for external quality assessment for a period of six months were recorded. The coefficient of variation (CV), bias, and total allowable error (TEa) were calculated to analyze the sigma (σ) values for 19 biochemical analytes...
December 2023: Curēus
https://read.qxmd.com/read/38259674/reduction-in-average-length-of-stay-in-emergency-department-of-a-low-income-country-s-cancer-hospital
#16
JOURNAL ARTICLE
Qurratulain Shakoor, Haroon Hafeez, Atif Saleem, Zubair Shabbir Khanzada, Hira Safir, Zainab Ajmal, Kashif Sajjad
INTRODUCTION: Prolonged length of stay (LOS) in emergency departments (ED) is a widespread problem in every hospital around the globe. Multiple factors cause it and can have a negative impact on the quality of care provided to the patients and the patient satisfaction rates. This project aimed to ensure that the average LOS of patients in a tertiary care cancer hospital stays below 3 hours. MATERIALS AND METHODS: The Six Sigma DMAIC (Define, Measure, Analyze, Improve, Control) approach was followed...
2024: Journal of cancer & allied specialties
https://read.qxmd.com/read/38240413/exploring-unconventional-%C3%AF-hole-interactions-computational-insights-into-the-interaction-of-xeo3-with-non-aromatic-coordinating-solvents
#17
JOURNAL ARTICLE
Soumya Ranjan Dash, Kumar Vanka
In order to control the explosiveness and shock sensitivity of XeO3, we have investigated its plausible interaction with various non-aromatic coordinating solvents, serving as potential Lewis base donors, through density functional theory (DFT) calculations. Out of twenty six such solvents, the top ten were thus identified and then thoroughly examined by employing various computational tools such as the mapping of the electrostatic potential surface (MESP), Wiberg bond indices (WBIs), non-covalent interaction (NCI) plots, Bader's theory of atoms-in-molecules (AIM), natural bond orbital (NBO) analysis, and the energy decomposition analysis (EDA)...
January 19, 2024: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://read.qxmd.com/read/38214242/optimizing-workflow-of-urgent-stroke-endovascular-intervention-a-focused-lean-six-sigma-project
#18
JOURNAL ARTICLE
Camilo R Gomez, Bradford Cardonell, Kimberley Pfeiffer, Donna Pond, Daphne Ingebritson, Brandi R French, Farhan Siddiq, Adnan I Qureshi
INTRODUCTION: Urgent endovascular intervention is currently accepted as the primary and critical therapeutic approach to patients whose acute ischemic stroke results from a large arterial occlusion (LAO). In this context, one of the quality metrics most widely applied to the assessment of emergency systems performance is the "door-to-puncture" (D-P) time. We undertook a project to identify the subinterval of the D-P metric causing the most impact on workflow delays and created a narrowly focused project on improving such subinterval...
January 10, 2024: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://read.qxmd.com/read/38197720/development-of-a-flipped-learning-course-to-deliver-and-scale-molecular-variant-evaluation-education-a-quality-improvement-initiative
#19
JOURNAL ARTICLE
Jessica R Balcom, Marissa S Ellingson, Carrie A Bowler, Darcy M Richardson, Teresa Kruisselbrink, Brittany C Thomas
Over the past several decades, molecular genetic testing volumes have grown and testing has expanded from single-gene assays to multigene panels, exome sequencing, and genome sequencing. The number of molecular genetic variants that require manual interpretation has grown simultaneously, resulting in an increased demand for education on molecular variant evaluation (MVE). To meet this growing need, a team of genetic counselors and educational experts undertook a quality improvement (QI) initiative with the objectives of assessing, standardizing, and scaling access to MVE education, without increasing instructor time to deliver the education...
January 10, 2024: Journal of Genetic Counseling
https://read.qxmd.com/read/38162416/comparison-of-sigma-metrics-computed-by-three-bias-estimation-approaches-for-33-chemistry-and-26-immunoassay-analytes
#20
JOURNAL ARTICLE
Şerif Ercan
OBJECTIVES: Sigma metric can be calculated using a simple equation. However, there are multiple sources for the elements in the equation that may produce different Sigma values. This study aimed to investigate the importance of different bias estimation approaches for Sigma metric calculation. METHODS: Sigma metrics were computed for 33 chemistry and 26 immunoassay analytes on the Roche Cobas 6000 analyzer. Bias was estimated by three approaches: (1) averaging the monthly bias values obtained from the external quality assurance (EQA) studies; (2) calculating the bias values from the regression equation derived from the EQA data; and (3) averaging the monthly bias values from the internal quality control (IQC) events...
September 2023: Adv Lab Med
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