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https://www.readbyqxmd.com/read/29793215/in-silico-insight-into-voltage-gated-sodium-channel-1-7-inhibition-for-anti-pain-drug-discovery
#1
Mingxing Wang, Wei Li, Ying Wang, Yongbo Song, Jian Wang, Maosheng Cheng
Studies on human genetics have implicated the voltage-gated sodium channel Nav1.7 as an appealing target for the treatment of pain. In this study, we put forward a ligand-based pharmacophore for the first time, which was generated by a set of multiple chemical scaffolds including sulfonamide and non-sulfonamide derivatives and consisted of four chemical features: an aromatic ring, a hydrophobic group and two hydrogen acceptors. The active cavity was divided into three regions according to the properties of the amino acids surrounded and was used for the docking of 16 known active inhibitors...
May 18, 2018: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/29793210/polypharmacological-profile-of-1-2-dihydro-2-oxo-pyridine-3-carboxamides-in-the-endocannabinoid-system
#2
Andrea Chicca, Chiara Arena, Simone Bertini, Francesca Gado, Elena Ciaglia, Mario Abate, Maria Digiacomo, Margherita Lapillo, Giulio Poli, Maurizio Bifulco, Marco Macchia, Tiziano Tuccinardi, Jürg Gertsch, Clementina Manera
The endocannabinoid system (ECS) represents one of the major neuromodulatory systems involved in different physiological and pathological processes. Multi-target compounds exert their activities by acting via multiple mechanisms of action and represent a promising pharmacological modulation of the ECS. In this work we report 4-substituted and 4,5-disubstituted 1,2-dihydro-2-oxo-pyridine-3-carboxamide derivatives with a broad spectrum of affinity and functional activity towards both cannabinoid receptors and additional effects on the main components of the ECS...
May 14, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29793177/long-noncoding-rna-gas5-suppresses-triple-negative-breast-cancer-progression-through-inhibition-of-proliferation-and-invasion-by-competitively-binding-mir-196a-5p
#3
Shuqin Li, Jun Zhou, Zhaoxin Wang, Peishun Wang, Xitao Gao, Yan Wang
Triple-negative breast cancer (TNBC) is considered to be the most aggressive and lethal type of breast cancer. Many studies have suggested that the dysfunction of long noncoding RNAs (lncRNAs) is correlated with breast cancer metastasis and progression. Here, we show that levels of the lncRNA, growth arrest-specific transcript 5 (GAS5), are decreased in TNBC tissues, and this down-regulation of GAS5 is associated with an aggressive tumor phenotype in patients, affecting clinical stage, lymph node metastasis and overall survival...
May 21, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29793150/exploring-the-victimization%C3%A2-early-substance-misuse-relationship-in-search-of-moderating-and-mediating-effects
#4
Glenn D Walters, Dorothy L Espelage
This study was designed to address two research questions. The first research question asked whether physical abuse victimization at the hands of parents/guardians, bullying victimization at the hands of peers, and the abuse x bullying interaction encouraged early involvement in substance misuse. The second research question inquired as to whether the victimization‒substance misuse relationship was mediated by variables proposed by various theories and research studies-specifically, cognitive impulsivity, negative affect, and low self-esteem...
May 21, 2018: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29793148/post-traumatic-stress-symptom-development-as-a-function-of-changing-witnessing-in-home-violence-and-changing-peer-post-traumatic-stress-symptom-development-as-a-function-of-changing-witnessing-in-home-violence-and-changing-peer-relationship-quality-evaluating
#5
Aura A Mishra, Sharon L Christ, Laura M Schwab-Reese, Nayantara Nair
In the present study, witnessing in-home violence and peer relationship quality are evaluated as to their relative impact on Post Traumatic Stress (PTS) symptoms among children aged 8 to 17 investigated by child protective services (CPS) for maltreatment exposure. The sample included 2151 children from the National Survey of Child and Adolescent Well-Being II (NSCAW II). Linear growth models were estimated to assess associations between changes in PTS symptoms, witnessing in-home violence, and peer relationship quality over time...
May 21, 2018: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29793146/development-of-a-novel-tridentate-ligand-for-colorimetric-detection-of-mn-2-based-on-agnps
#6
Jianyu Wei, Jinfan Chen, Guozong Yue, Liangsheng Hu, Danqing Zhao, Jing Zhu, Luming Yang, Deshun Huang, Pengxiang Zhao
A novel tridentate ligand nitrilotris(methylene)tris(1,2,3-triazole)triacetate (NTTTA) has been synthesized by click reaction and followed with ester hydrolysis reaction. The silver nanoparticles (AgNPs) were then modified and stabilized by this ligand, and subsequently been employed for the highly selective and sensitive colorimetric detection of Mn2+ in aqueous solution. The presence of Mn2+ can cause the aggregation of AgNPs, which leads to the color change of the dispersion from yellow to brown, as well as the decrease and red-shift of the surface plasmon resonance absorption...
May 9, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29793140/effectiveness-of-a-voluntary-family-befriending-service-a-mixed-methods-evaluation-using-the-donabedian-model
#7
S V Gentry, E F J Powers, N Azim, M Maidrag
OBJECTIVES: Voluntary befriending schemes operate in many countries, promoting public health by supporting vulnerable individuals and families. Use of third sector and voluntary services to complement health and social care provision is increasingly important globally in the context of economic and demographic challenges, but the evidence base around such collaborations is limited. This article reports the results of operational evaluation research seeking to use robust routine work to generate transferable findings for use by those commissioning and providing services...
May 21, 2018: Public Health
https://www.readbyqxmd.com/read/29793105/copd-rat-model-is-more-susceptible-to-cold-stress-and-pm-2-5-exposure-and-the-underlying-mechanism
#8
Kai Zhang, Lei Guo, Qiaozhen Wei, Quanquan Song, Jiangtao Liu, Jingping Niu, Li Zhang, Ye Ruan, Bin Luo
The purpose of this study is to verify the hypothesis that chronic obstructive pulmonary disease (COPD) model rat is more susceptible to cold stress and fine particulate matter (PM2.5 ) exposure than the healthy rat, and explore the related mechanism. COPD rat model, established with cigarette smoke and lipopolysaccharide intratracheal instillation, were exposed to cold stress (0 °C) and PM2.5 (0, 3.2, 12.8 mg/ml). After that, the levels of superoxide dismutase, inducible nitric oxide synthase (iNOS), tumor necrosis factor alpha (TNF-α), monocyte chemotactic protein 1 (MCP-1) and angiotensin Ⅱ (Ang-Ⅱ) in lung were measured, as well as the expression levels of lung 8-hydroxy-2-deoxyguanosine (8-OHdG), nuclear factor kappa B (NF-κB), heme-oxygenase-1 (HO-1) and nuclear factor erythroid-2-related factor 2 (Nrf2)...
May 21, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29793098/evaluation-of-analgesic-and-anti-inflammatory-activities-of-rubia-cordifolia-l-by-spectrum-effect-relationships
#9
REVIEW
Cai-Hong Shen, Cui-Ting Liu, Xiao-Juan Song, Wei-Ya Zeng, Xiao-Ying Lu, Zuo-Liang Zheng, Jie-Pan, Ruo-Ting Zhan, Ping-Yan
The objective of the current work was to evaluate the spectrum-effect relationships between high-performance liquid chromatography fingerprints and analgesic and anti-inflammatory effects of Rubia cordifolia L. extract (RCE), and to identify active components of RCE. Chemical fingerprints of ten batches of RC from various sources were obtained by HPLC, and similarity and hierarchical clustering analyses were carried out. Pharmacodynamic assays were performed in adjuvant-induced arthritis rat model to assess the analgesic and anti-inflammatory properties of RCE...
May 17, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29793092/a-combined-ftir-and-dsc-study-on-the-bilayer-stabilising-effect-of-electrostatic-interactions-in-ion-paired-lipids
#10
Maximilian Schmid, Christian Wölk, Julia Giselbrecht, K L Andrew Chan, Richard D Harvey
Investigating lipid ion pair formation is important for understanding the mechanisms of lipid-mediated drug resistance in bacteria. In this study we have used the charged amphiphiles dipalmitoylphosphatidylglycerol (DPPG) and dihexadecyldimethylammonium bromide (DHDAB), as a model to evaluate the formation of ion pairs by a combined Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC) analysis. FTIR was employed to study the environment of the DPPC headgroup phosphate and lipid/surfactant alkane chains, in vesicles formed by the two amphiphiles mixed in various molar ratios...
May 17, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29793084/subthreshold-depression-among-diabetes-patients-in-beijing-cross-sectional-associations-among-sociodemographic-clinical-and-behavior-factors
#11
Dandan Wang, Lintao Shi, Leling Li, Xiaohui Guo, Yufeng Li, Yuan Xu, Shinan Yin, Qiaozhen Wu, Yu Yang, Xiaoming Zhuang, Yingli Gai, Quanmin Li, Yanjun Liu
BACKGROUND: This study explores the prevalence of subthreshold depression (SubD) and its association with factors in type 2 diabetes mellitus (T2DM) patients. METHODS: This cross-sectional study involved 808 outpatients with T2DM from ten hospitals in Beijing between September 2015 and January 2016. All participants completed the Patient Health Questionnaire 9-item (PHQ-9) to evaluate depressive status, with scores between 5 and 14 considered SubD. Conditional logistic regression was conducted to investigate the variables associated with SubD in T2DM patients...
May 18, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29793079/shifts-in-wind-energy-potential-following-land-use-driven-vegetation-dynamics-in-complex-terrain
#12
Jiannong Fang, Alexander Peringer, Mihai-Sorin Stupariu, Ileana Pǎtru-Stupariu, Alexandre Buttler, Francois Golay, Fernando Porté-Agel
Many mountainous regions with high wind energy potential are characterized by multi-scale variabilities of vegetation in both spatial and time dimensions, which strongly affect the spatial distribution of wind resource and its time evolution. To this end, we developed a coupled interdisciplinary modeling framework capable of assessing the shifts in wind energy potential following land-use driven vegetation dynamics in complex mountain terrain. It was applied to a case study area in the Romanian Carpathians...
May 21, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29793068/prenatal-phthalate-exposure-birth-outcomes-and-dna-methylation-of-alu-and-line-1-repetitive-elements-a-pilot-study-in-china
#13
Li-Li Huang, Bin Zhou, Song-Hua Ai, Pan Yang, Ying-Jun Chen, Chong Liu, Yan-Ling Deng, Qing Lu, Xiao-Ping Miao, Wen-Qing Lu, Yi-Xin Wang, Qiang Zeng
BACKGROUND: Epigenetic mechanisms, such as altered DNA methylation, may participate in the relationship between prenatal phthalate exposure and adverse birth outcomes. OBJECTIVE: To explore the mediation effect of DNA methylation in the associations of phthalate exposure before delivery with birth outcomes in a Chinese cohort. METHODS: Eight phthalate metabolites in maternal urine before delivery and DNA methylation of Alu and long interspersed nucleotide elements (LINE-1) in cord blood were determined among 106 mother-infant pairs...
May 7, 2018: Chemosphere
https://www.readbyqxmd.com/read/29793030/sorption-of-perfluoroalkyl-substances-pfass-to-an-organic-soil-horizon-effect-of-cation-composition-and-ph
#14
Hugo Campos Pereira, Malin Ullberg, Dan Berggren Kleja, Jon Petter Gustafsson, Lutz Ahrens
Accurate prediction of the sorption of perfluoroalkyl substances (PFASs) in soils is essential for environmental risk assessment. We investigated the effect of solution pH and calculated soil organic matter (SOM) net charge on the sorption of 14 PFASs onto an organic soil as a function of pH and added concentrations of Al3+ , Ca2+ and Na+ . Often, the organic C-normalized partitioning coefficients (KOC ) showed a negative relationship to both pH (Δlog KOC /ΔpH = -0.32 ± 0.11 log units) and the SOM bulk net negative charge (Δlog KOC  = -1...
May 4, 2018: Chemosphere
https://www.readbyqxmd.com/read/29793014/calf-muscle-oxygen-saturation-during-six-minute-walk-test-and-its-relationship-with-walking-impairment-in-symptomatic-peripheral-artery-disease
#15
Aluísio Andrade-Lima, Gabriel G Cucato, Wagner J R Domingues, Antônio H Germano-Soares, Bruno R Cavalcante, Marilia A Correia, Glauco F Saes, Nelson Wolosker, Andrew W Gardner, Antônio E Zerati, Raphael M Ritti-Dias
OBJECTIVE: Impaired microcirculation is associated with poor walking capacity in symptomatic peripheral artery disease (PAD) patients during treadmill test, however, this test does not simulate the efforts of daily walking of these patients. Thus, the aim of the study was to describe the microcirculation responses during six-minute walk test (6MWT) and to analyze the relationship between microcirculation indicators and walking impairment in symptomatic PAD patients. METHODS: Thirty-four patients were included (mean age = 67...
May 21, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29792997/risk-factors-for-low-back-pain-and-sciatica-an-umbrella-review
#16
REVIEW
P Parreira, C Maher, D Steffens, M Hancock, M Ferreira
BACKGROUND: Low back pain (LBP) is a highly prevalent condition and it is associated with significant disability and work absenteeism worldwide. A variety of environmental and individual characteristics have been reported to increase the risk of low back pain (LBP). To our knowledge, there has been no previous attempt to summarise the evidence from existing systematic reviews of risk factors for LBP and/or sciatica PURPOSE: to provide an overview of risk factors for LBP, we completed an umbrella review of the evidence from existing systematic reviews...
May 21, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29792990/identification-of-group-a-rotaviruses-from-zambian-fruit-bats-provides-evidence-for-long-distance-dispersal-events-in-africa
#17
Michihito Sasaki, Masahiro Kajihara, Katendi Changula, Akina Mori-Kajihara, Hirohito Ogawa, Bernard M Hang'ombe, Aaron S Mweene, Martin Simuunza, Reiko Yoshida, Michael Carr, Yasuko Orba, Ayato Takada, Hirofumi Sawa
Group A rotavirus (RVA) is a major cause of diarrhea in children worldwide. Although RVA infects many animals, little is known about RVA in bats. The present study investigated the genetic diversity of RVA in Zambian bats. We identified RVA from two straw-colored fruit bats (Eidolon helvum) and an Egyptian fruit bat (Rousettus aegyptiacus), and analyzed the genome sequences of these strains. Genome segments of the RVA strains from Zambian E. helvum showed 97%-99% nucleotide sequence identity with those of other RVA strains from E...
May 21, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29792975/bladder-agenesis-and-associated-pelvic-arterial-anomaly-in-two-female-pediatric-patients
#18
Thomas Lowrey, Shellie Josephs, Linda A Baker
Bladder agenesis is an extremely rare congenital anomaly of the genitourinary tract. Two female patients with known diagnoses of bladder agenesis presented for pre-renal transplant evaluation and neobladder creation. Similar unique pelvic arterial malformations were identified through pre-operative imaging and intraoperative examination. With these similar findings, it could be proposed that such anatomical variants are products of the same insult or involve a causal relationship, with vascular aberrancies potentially provoking pelvic organ maldevelopment...
May 21, 2018: Urology
https://www.readbyqxmd.com/read/29792972/association-between-early-confirmatory-testing-and-the-adoption-of-active-surveillance-for-men-with-favorable-risk-prostate-cancer
#19
Deborah R Kaye, Ji Qi, Todd M Morgan, Susan Linsell, Brian R Lane, James E Montie, Michael L Cher, David C Miller
OBJECTIVE: To examine the relationship between the use and results of early confirmatory testing and persistence on active surveillance (AS). METHODS: We identified all men in the MUSIC registry diagnosed with favorable-risk prostate cancer from 01/2016-02/2017. We next examined trends in the use of early confirmatory test(s), defined as repeat biopsy, prostate MRI and/or molecular classifiers obtained within 6-months of the initial cancer diagnosis, in patients with favorable-risk prostate cancer...
May 21, 2018: Urology
https://www.readbyqxmd.com/read/29792949/srnaome-and-transcriptome-analysis-provide-insight-into-chilling-response-of-cowpea-pods
#20
Jinhua Zuo, Yunxiang Wang, Benzhong Zhu, Yunbo Luo, Qing Wang, Lipu Gao
Cowpea is an important horticultural crop in tropical and subtropical areas of Asia, Africa, and Latin America, as well as parts of southern Europe and Central and South America. Chilling injury is a common physiological hazard of cowpea in cold chain logistics which reduce the cowpea pod's nutritional quality and product value. However, the molecular mechanism involved in chilling injury remains unclear in cowpea pods. RNA-Seq and sRNA-Seq technologies were employed to decipher the miRNAs and mRNAs expression profiles and their regulatory networks in cowpea pods involved in chilling stress...
May 21, 2018: Gene
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