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https://www.readbyqxmd.com/read/28102357/a-single-identified-glomerulus-in-the-zebrafish-olfactory-bulb-carries-the-high-affinity-response-to-death-associated-odor-cadaverine
#1
Milan Dieris, Gaurav Ahuja, Venkatesh Krishna, Sigrun I Korsching
The death-associated odor cadaverine, generated by bacteria-mediated decarboxylation of lysine, has been described as the principal activator of a particular olfactory receptor in zebrafish, TAAR13c. Low concentrations of cadaverine activated mainly TAAR13c-expressing olfactory sensory neurons, suggesting TAAR13c as an important element of the neuronal processing pathway linking cadaverine stimulation to a strongly aversive innate behavioral response. Here, we characterized the initial steps of this neuronal pathway...
January 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28101829/autism-spectrum-disorders%C3%A2-diagnosis-and-management
#2
REVIEW
Sharmila Banerjee Mukherjee
Autism Spectrum Disorder (ASD) is a neuro-developmental disorder commonly seen in children. It is characterized by age inappropriate, impaired social communication and the presence of stereotypic behavior. This disorder is hypothesized to result from cerebral dysfunction arising from a complex interaction between genetic, epigenetic and environmental factors. ASD should be suspected in children failing ASD specific screening tests, in the presence of red flags in social, language and/or play domains, in children with developmental or language delay, abnormal behavior, poor school performance or in those who are at high risk...
January 19, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28100633/automated-mitotic-spindle-tracking-suggests-a-link-between-spindle-dynamics-spindle-orientation-and-anaphase-onset-in-epithelial-cells
#3
Matthew Larson, William Bement
Proper spindle positioning at anaphase onset is essential for normal tissue organization and function. Here we develop automated spindle tracking software and apply it to characterize mitotic spindle dynamics in the Xenopus laevis embryonic epithelium. We find that metaphase spindles first undergo a sustained rotation that brings them on-axis with their final orientation. This sustained rotation is followed by a set of striking, stereotyped rotational oscillations that bring the spindle into near contact with the cortex and then move it rapidly away from the cortex...
January 18, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28097289/binding-of-cll-subset-4-b-cell-receptor-immunoglobulins-to-viable-human-memory-b-lymphocytes-requires-a-distinctive-igkv-somatic-mutation
#4
Rosa Catera, Yun Liu, Chao Gao, Xiao-Jie Yan, Amanda Magli, Steven L Allen, Jonathan E Kolitz, Kanti R Rai, Charles C Chu, Ten Feizi, Kostas Stamatopoulos, Nicholas Chiorazzi
Amino acid replacement mutations in certain CLL stereotyped B-cell receptor (BCR) immunoglobulins (IGs) at defined positions within antigen-binding sites strongly imply antigen selection. Prime examples of this are CLL subset 4 BCR IGs using IGHV4-34/IGHD5-18/IGHJ6 and IGKV2-30/IGKJ2 rearrangements. Conspicuously and unlike most CLL IGs, subset 4 IGs do not bind apoptotic cells. By testing the (auto)antigenic reactivities of subset 4 IGs toward viable lymphoid-lineage cells and specific autoantigens typically bound by IGHV4-34(+) IGs, we found IGs from both subset 4 and non-subset 4 IGHV4-34-expressing CLL cases bind naïve B cells...
January 12, 2017: Molecular Medicine
https://www.readbyqxmd.com/read/28094772/cardiac-afferent-activity-modulates-the-expression-of-racial-stereotypes
#5
Ruben T Azevedo, Sarah N Garfinkel, Hugo D Critchley, Manos Tsakiris
Negative racial stereotypes tend to associate Black people with threat. This often leads to the misidentification of harmless objects as weapons held by a Black individual. Yet, little is known about how bodily states impact the expression of racial stereotyping. By tapping into the phasic activation of arterial baroreceptors, known to be associated with changes in the neural processing of fearful stimuli, we show activation of race-threat stereotypes synchronized with the cardiovascular cycle. Across two established tasks, stimuli depicting Black or White individuals were presented to coincide with either the cardiac systole or diastole...
January 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/28093559/gradation-approx-10-size-states-of-synaptic-strength-by-quantal-addition-of-structural-modules
#6
Kang K L Liu, Michael F Hagan, John E Lisman
Memory storage involves activity-dependent strengthening of synaptic transmission, a process termed long-term potentiation (LTP). The late phase of LTP is thought to encode long-term memory and involves structural processes that enlarge the synapse. Hence, understanding how synapse size is graded provides fundamental information about the information storage capability of synapses. Recent work using electron microscopy (EM) to quantify synapse dimensions has suggested that synapses may structurally encode as many as 26 functionally distinct states, which correspond to a series of proportionally spaced synapse sizes...
March 5, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28093257/selective-preservation-of-cholinergic-mecp2-rescues-specific-rett-syndrome-like-phenotypes-in-mecp2-stop-mice
#7
Huanhuan Zhou, Wei Wu, Ying Zhang, Haiyang He, Zhefeng Yuan, Zhiwei Zhu, Zhengyan Zhao
RTT is a neurodevelopmental disorder characterized by growth regression, motor dysfunction, stereotypic hand movements, and autism features. Typical Rett syndrome (RTT) is predominantly caused by mutations in X-linked MeCP2 gene which encodes methyl-CpG-binding protein 2 (MeCP2). The brain-abundant MeCP2 protein mainly functions as a transcriptional regulator for neurodevelopment-associated genes. Specific functions of MeCP2 in certain neuron types remain to be known. Although cholinergic system is an important modulating system in brain, how MeCP2 in cholinergic neurons contribute to RTT has not been clearly understood...
January 13, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28090698/presentation-and-validation-of-the-duckees-child-and-adolescent-dynamic-facial-expressions-stimulus-set
#8
Nicole R Giuliani, John C Flournoy, Elizabeth J Ivie, Arielle Von Hippel, Jennifer H Pfeifer
The stimulus sets presently used to study emotion processing are primarily static pictures of individuals (primarily adults) making emotional facial expressions. However, the dynamic, stereotyped movements associated with emotional expressions contain rich information missing from static pictures, such as the difference between happiness and pride. We created a set of 1.1 s dynamic emotional facial stimuli representing boys and girls aged 8-18. A separate group of 36 individuals (mean [M] age = 19.5 years, standard deviation [SD] = 1...
January 16, 2017: International Journal of Methods in Psychiatric Research
https://www.readbyqxmd.com/read/28090170/gender-s-role-in-misperceptions-of-peers-sexual-motives
#9
Rose Wesche, Graciela Espinosa-Hernández, Eva S Lefkowitz
The sexual double standard influences men's and women's sexual attitudes and behavior, leading men and women to consider distinct sexual motives, or reasons whether or not to engage in sexual intercourse (Crawford & Popp 2003; Reiss 1964). The goal of the present paper was to document how the sexual double standard shapes perceptions of peers' sexual motives. We build on past research by using open-ended questions and measuring perceptions of both same-gender and other-gender peers. The sample included 154 heterosexual college students (50% female, 49% European American, 25% Latino American, 26% African American) recruited via probability sampling...
December 2016: Sexuality & Culture
https://www.readbyqxmd.com/read/28088047/sliding-doors-did-drama-based-inter-professional-education-improve-the-tensions-round-person-centred-nursing-and-social-care-delivery-for-people-with-dementia-a-mixed-method-exploratory-study
#10
Lindsay Dingwall, Jane Fenton, Timothy B Kelly, John Lee
This educational intervention takes place when the population of older people with dementia is increasing. Health and Social care professionals must work jointly in increasingly complex contexts. Negative attitudes towards older people are cited as a contributor to poor care delivery, including the use of dismissive and/or patronising language, failing to meet fundamental needs and afford choice. 'Sliding Doors to Personal Futures' is a joint, drama-based, educational initiative between NHS Education Scotland and the Scottish Social Services Council, delivered using interprofessional education (IPE) towards encouraging person-centred health and social care...
December 21, 2016: Nurse Education Today
https://www.readbyqxmd.com/read/28080088/the-effect-of-reactive-emotions-expressed-in-response-to-another-s-anger-on-inferences-of-social-power
#11
Shlomo Hareli, Shlomo David
Social perception of emotions is influenced by the context in which it occurs. One such context is a social interaction involving an exchange of emotions. The way parties to the interaction are perceived is shaped by the combination of emotions exchanged. This idea was examined by assessing the extent to which expressions of anger toward a target-which, in isolation, are perceived as signals of high social power-are influenced by the target's emotional reaction to it (i.e., reactive emotions). Three studies show that the angry person was perceived as having a higher level of social power when this anger was responded by fear or sadness than when it was responded by neutrality or anger...
January 12, 2017: Emotion
https://www.readbyqxmd.com/read/28077728/looking-the-part-to-me-effects-of-racial-prototypicality-on-race-perception-vary-by-prejudice
#12
Brittany S Cassidy, Gregory T Sprout, Jonathan B Freeman, Anne C Krendl
Less racially prototypic faces elicit more category competition during race categorization. Top-down factors (e.g. stereotypes), however, affect categorizations, suggesting racial prototypicality may enhance category competition in certain perceivers. Here, we examined how prejudice affects race category competition and stabilization when perceiving faces varying in racial prototypicality. Prototypically low vs high Black relative to White faces elicited more category competition and slower response latencies during categorization (Experiment 1), suggesting a pronounced racial prototypicality effect on minority race categorization...
January 10, 2017: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/28077263/learning-in-mosquito-larvae-aedes-aegypti-habituation-to-a-visual-danger-signal
#13
Hugo Baglan, Claudio Lazzari, Fernando Guerrieri
In spite of the mosquito Aedes aegypti being a vector of several infectious diseases, a limited number of studies has been undertaken on learning in this species. Moreover, larval stages have been neglected as model organisms, although they are active, aquatic and perform stereotyped behavioural responses, e.g. the escape response when disturbed. To study the learning abilities of mosquito larvae, we focused on habituation, a form of non-associative learning widely studied in vertebrates and invertebrates. Habituation was defined as the progressive and reversible decrease in response to a reiterative stimulus...
January 7, 2017: Journal of Insect Physiology
https://www.readbyqxmd.com/read/28073332/an-examination-of-age-based-stereotype-threat-about-cognitive-decline
#14
Sarah J Barber
"Stereotype threat" is often thought of as a singular construct, with moderators and mechanisms that are stable across groups and domains. However, this is not always true. To illustrate this, the current review focuses on the stereotype threat that older adults face about their cognitive abilities. Drawing upon the multithreat framework, I first provide evidence that this is a self-concept threat and not a group-reputation threat. Because this differs from the forms of stereotype threat experienced by other groups (e...
January 2017: Perspectives on Psychological Science: a Journal of the Association for Psychological Science
https://www.readbyqxmd.com/read/28070918/stereotype-threat-and-social-function-in-opioid-substitution-therapy-patients
#15
Courtney von Hippel, Julie D Henry, Gill Terrett, Kimberly Mercuri, Karen McAlear, Peter G Rendell
OBJECTIVES: People with a history of substance abuse are subject to widespread stigmatization. It seems likely that this societal disapproval will result in feelings of stereotype threat, or the belief that one is the target of demeaning stereotypes. If so, stereotype threat has the potential to contribute to functional difficulties including poor social outcomes. METHODS: Eighty drug users on opioid substitution therapy and 84 demographically matched controls completed measures of mental health and social function...
January 10, 2017: British Journal of Clinical Psychology
https://www.readbyqxmd.com/read/28070688/pharmacists-and-patients-feedback-on-empirically-designed-prescription-warning-labels-a-qualitative-study
#16
Olayinka O Shiyanbola, Paul D Smith, Yen-Ming Huang, Sonal Ghura Mansukhani
Background Recommendations call for the inclusion of both patient and provider input in the redesign of prescription labels. Pharmacist opinions on prescription warning labels are important because they are the health providers who would eventually distribute and explain the revised labels during medication counseling. They may be the first health provider to notice a patient's misunderstanding on how to safely use their prescription medications. Objectives To explore the perspectives of patients and pharmacists on five newly designed PWLs, and examine if there were similarities and differences between patients' and pharmacists' perspectives...
January 9, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28069955/ambivalent-stereotypes-link-to-peace-conflict-and-inequality-across-38-nations
#17
Federica Durante, Susan T Fiske, Michele J Gelfand, Franca Crippa, Chiara Suttora, Amelia Stillwell, Frank Asbrock, Zeynep Aycan, Hege H Bye, Rickard Carlsson, Fredrik Björklund, Munqith Dagher, Armando Geller, Christian Albrekt Larsen, Abdel-Hamid Abdel Latif, Tuuli Anna Mähönen, Inga Jasinskaja-Lahti, Ali Teymoori
A cross-national study, 49 samples in 38 nations (n = 4,344), investigates whether national peace and conflict reflect ambivalent warmth and competence stereotypes: High-conflict societies (Pakistan) may need clearcut, unambivalent group images distinguishing friends from foes. Highly peaceful countries (Denmark) also may need less ambivalence because most groups occupy the shared national identity, with only a few outcasts. Finally, nations with intermediate conflict (United States) may need ambivalence to justify more complex intergroup-system stability...
January 9, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28068132/east-asian-adolescents-ethnic-identity-development-and-cultural-integration-a-qualitative-investigation
#18
Eunju Yoon, Kristen Adams, Angela Clawson, Hanna Chang, Shruti Surya, Gihane Jérémie-Brink
Drawing on the current conceptualization of acculturation/enculturation as bilinear, multidimensional processes proceeding in interaction with surrounding contexts, this study examined ethnic identity development and cultural integration of 13 adolescents from East Asian immigrant families. Five domains emerged via the Consensual Qualitative Research method: ethnic/cultural identity and socialization; bicultural living; racial context-racism and stereotypes; family context-parental expectation; and peer context-friendship/dating...
January 2017: Journal of Counseling Psychology
https://www.readbyqxmd.com/read/28068131/development-and-evaluation-of-the-internalized-racism-in-asian-americans-scale-iraas
#19
Andrew Young Choi, Tania Israel, Hotaka Maeda
This article presents the development and psychometric evaluation of the Internalized Racism in Asian Americans Scale (IRAAS), which was designed to measure the degree to which Asian Americans internalized hostile attitudes and negative messages targeted toward their racial identity. Items were developed on basis of prior literature, vetted through expert feedback and cognitive interviews, and administered to 655 Asian American participants through Amazon Mechanical Turk. Exploratory factor analysis with a random subsample (n = 324) yielded a psychometrically robust preliminary measurement model consisting of 3 factors: Self-Negativity, Weakness Stereotypes, and Appearance Bias...
January 2017: Journal of Counseling Psychology
https://www.readbyqxmd.com/read/28067761/mechanisms-to-avoid-and-correct-erroneous-kinetochore-microtubule-attachments
#20
REVIEW
Michael A Lampson, Ekaterina L Grishchuk
In dividing vertebrate cells multiple microtubules must connect to mitotic kinetochores in a highly stereotypical manner, with each sister kinetochore forming microtubule attachments to only one spindle pole. The exact sequence of events by which this goal is achieved varies considerably from cell to cell because of the variable locations of kinetochores and spindle poles, and randomness of initial microtubule attachments. These chance encounters with the kinetochores nonetheless ultimately lead to the desired outcome with high fidelity and in a limited time frame, providing one of the most startling examples of biological self-organization...
January 5, 2017: Biology
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