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https://www.readbyqxmd.com/read/27350145/subchronic-and-genetic-safety-evaluation-of-a-calcium-fructoborate-in-rats
#1
Palma Ann Marone, James T Heimbach, Boris Nemzer, John M Hunter
A branded calcium fructoborate product, a nature-identical calcium salt of bis (fructose) ester of boric acid found in plants and a natural source of boron in the human diet and sold under the trade name FruiteX-B(®) Brand Calcium Fructoborate ("FrxB"), was evaluated in a 90-day dietary toxicity study and two genotoxicity studies. In the 90-day study, four groups of 10 male and 10 female Crl:SD CD(®) IGS rats were fed diets with FrxB admixtures of 0.56, 1.12, and 1.68% dietary concentration, providing mean overall daily intakes of FrxB in male rats of 385...
September 2016: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/26686846/calcium-fructoborate-for-bone-and-cardiovascular-health
#2
George Dan Mogoşanu, Andrei Biţă, Ludovic Everard Bejenaru, Cornelia Bejenaru, Octavian Croitoru, Gabriela Rău, Otilia-Constantina Rogoveanu, Dan Nicolae Florescu, Johny Neamţu, Iulia Daria Scorei, Romulus Ion Scorei
Calcium fructoborate (CF), a natural sugar-borate ester found in fresh fruits and vegetables, is a source of soluble boron. CF contains three forms of borate (diester, monoester, and boric acid) and all are biologically active, both at the intracellular (as free boric acid) and extracellular level (as fructose-borate diester and monoester). At the cellular and molecular level, CF is superior to the boric acid/borate, exhibiting a complex "protective" effect against inflammatory response. CF is commercially available in the USA as a "nature-identical" complex, an active compound for dietary supplements...
August 2016: Biological Trace Element Research
https://www.readbyqxmd.com/read/25632274/effects-of-a-dietary-supplement-on-golf-drive-distance-and-functional-indices-of-golf-performance
#3
Tim N Ziegenfuss, Scott M Habowski, Robert Lemieux, Jennifer E Sandrock, A William Kedia, Chad M Kerksick, Hector L Lopez
BACKGROUND: Limited research exists examining the impact of nutrition on golfing performance. This study's purpose was to determine the impact of daily supplementation with an over-the-counter dietary supplement on golf performance. METHODS: Healthy men (30.3 ± 6.9 y, 183.1 ± 5.6 cm, 86.7 ± 11.9 kg), with a 5-15 handicap were assigned in a double-blind, placebo-controlled manner to ingest for 30 days either a placebo (PLA, n = 13) or a dietary supplement containing creatine monohydrate, coffea arabica fruit extract, calcium fructoborate and vitamin D (Strong Drive™, SD, n = 14)...
2015: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/25433580/effects-of-calcium-fructoborate-on-levels-of-c-reactive-protein-total-cholesterol-low-density-lipoprotein-triglycerides-il-1%C3%AE-il-6-and-mcp-1-a-double-blind-placebo-controlled-clinical-study
#4
RANDOMIZED CONTROLLED TRIAL
Otilia-Constantina Rogoveanu, George Dan Mogoşanu, Cornelia Bejenaru, Ludovic Everard Bejenaru, Octavian Croitoru, Johny Neamţu, Zbigniew Pietrzkowski, Tania Reyes-Izquierdo, Andrei Biţă, Iulia Daria Scorei, Romulus Ion Scorei
Calcium fructoborate (CFB) has been reported as supporting healthy inflammatory response. In this study, we assess the effects of CFB on blood parameters and proinflammatory cytokines in healthy subjects. This was a randomized, double-blinded, placebo-controlled trial. Participants received placebo or CFB at a dose of 112 mg/day (CFB-1) or 56 mg/day (CFB-2) for 30 days. Glucose, total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides (TG), C-reactive protein (CRP), homocysteine, interleukin 1 beta (IL-1β), IL-6, and monocyte chemoattractant protein-1 (MCP-1) were determined before and after supplementation...
February 2015: Biological Trace Element Research
https://www.readbyqxmd.com/read/24940052/short-term-efficacy-of-calcium-fructoborate-on-subjects-with-knee-discomfort-a-comparative-double-blind-placebo-controlled-clinical-study
#5
RANDOMIZED CONTROLLED TRIAL
Zbigniew Pietrzkowski, Michael J Phelan, Robert Keller, Cynthia Shu, Ruby Argumedo, Tania Reyes-Izquierdo
Calcium fructoborate (CFB) at a dose of 110 mg twice per day was previously reported to improve knee discomfort during the first 14 days of treatment. In this study, 60 participants with self-reported knee discomfort were randomized into two groups receiving CFB or placebo. Initial levels of knee discomfort were evaluated by Western Ontario and McMaster Universities Arthritis Index (WOMAC) and McGill Pain Questionnaire (MPQ) scores at the beginning of the study and also at 7 and 14 days after treatment. Results showed that supplementation with CFB significantly improved knee discomfort in the study subjects; significant reductions of mean within-subject change in WOMAC and MPQ scores were observed for the CFB group compared to the placebo group at both 7 and 14 days after treatment...
2014: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/23982445/calcium-fructoborate-helps-control-inflammation-associated-with-diminished-bone-health
#6
REVIEW
Iulia Daria Scorei, Romulus Ion Scorei
Inflammation has been identified as a possible contributory factor to disruption of the normal bone remodeling process, a process essential to healthy bone mineral density. Several large population-based clinical studies have specifically shown that levels of C-reactive protein, an immune recognition protein that is a sensitive marker of inflammation, are inversely and independently associated with total bone mineral density. The evidence suggests that control of C-reactive protein levels may contribute to bone health by protecting against inflammation's disruption of the equilibrium between bone resorption and bone deposition...
December 2013: Biological Trace Element Research
https://www.readbyqxmd.com/read/23153742/oral-resveratrol-and-calcium-fructoborate-supplementation-in-subjects-with-stable-angina-pectoris-effects-on-lipid-profiles-inflammation-markers-and-quality-of-life
#7
RANDOMIZED CONTROLLED TRIAL
Constantin Militaru, Ionut Donoiu, Alina Craciun, Iulia Daria Scorei, Anca Mihaela Bulearca, Romulus Ion Scorei
OBJECTIVE: This study aimed to evaluate the effects of short-term (60-d) oral supplementation with calcium fructoborate, resveratrol, and their combination on the clinical and biological statuses of subjects with stable angina pectoris. METHODS: A randomized, double-blinded, active-controlled, parallel clinical trial was conducted in three groups of subjects. Of the total number of subjects included in study (n = 166), 87 completed the 60-d test treatment study period and 29 followed in parallel their usual medical care and treatment...
January 2013: Nutrition
https://www.readbyqxmd.com/read/22435474/calcium-fructoborate-plant-based-dietary-boron-for-human-nutrition
#8
REVIEW
Dusan Miljkovic, Romulus Ion Scorei, Vily Marius Cimpoiaşu, Iulia Daria Scorei
The main objective of this paper is to evaluate the scientific evidence on the form of organic boron, calcium fructoborate (CF), including health dates, dietary needs, pharmacology, experts opinion, research papers, clinical evidence, and dosing. CF is a natural product with effects in oxidative metabolism and cell apoptosis. We review the biological and biochemical action of chemical natural-identical entity of CF. This mini review provides support for future clinical research.
2009: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/21607703/a-double-blind-placebo-controlled-pilot-study-to-evaluate-the-effect-of-calcium-fructoborate-on-systemic-inflammation-and-dyslipidemia-markers-for-middle-aged-people-with-primary-osteoarthritis
#9
RANDOMIZED CONTROLLED TRIAL
Romulus Scorei, Paul Mitrut, Iulian Petrisor, Iulia Scorei
The objective of this pilot study was to determine whether 15 days of dietary supplementation with calcium fructoborate could acutely modulate inflammatory and lipid blood markers in individuals diagnosed with primary osteoarthritis. During 2 weeks, a placebo-controlled, randomized, double-blind study was conducted on 116 subjects that were initially recruited. Seventy-two subjects started the study, being divided into four groups, and only 60 completed the study as designed. The aim was to compare the effects of calcium fructoborate to placebo on subjects diagnosed with knee primary osteoarthritis...
December 2011: Biological Trace Element Research
https://www.readbyqxmd.com/read/21396141/assessment-of-the-potential-of-a-boron-fructose-additive-in-counteracting-the-toxic-effect-of-fusarium-mycotoxins
#10
Ionelia Taranu, Daniela E Marin, Gina Manda, Monica Motiu, Ionela Neagoe, Cristina Tabuc, Mariana Stancu, Margareta Olteanu
Trichotecenes are mycotoxins produced by Fusarium sp., which may contaminate animal feeds and human food. A feeding trial was conducted to evaluate the effect of a fusarotoxin-contaminated diet, and to explore the counteracting potential of a calcium fructoborate (CFrB) additive on performance, typical health biochemistry parameters and immune response in weaned pigs. A naturally contaminated maize, containing low doses of deoxynivalenol, zearalenone, fumonisins and T-2/HT-2 toxins (1790, 20, 0·6 and 90 parts per billion), was included in a maize-soyabean meal diet, and given ad libitum to eight weaned piglets (two groups: four pigs/group) for a period of 24 d...
August 2011: British Journal of Nutrition
https://www.readbyqxmd.com/read/21274653/calcium-fructoborate-potential-anti-inflammatory-agent
#11
REVIEW
Romulus Ion Scorei, Petre Rotaru
Calcium fructoborate is a boron-based nutritional supplement. Its chemical structure is similar to one of the natural forms of boron such as bis-manitol, bis-sorbitol, bis-fructose, and bis-sucrose borate complexes found in edible plants. In vitro studies revealed that calcium fructoborate is a superoxide ion scavenger and anti-inflammatory agent. It may influence macrophage production of inflammatory mediators, can be beneficial for the suppression of cytokine production, and inhibits progression of endotoxin-associated diseases, as well as the boric acid and other boron sources...
December 2011: Biological Trace Element Research
https://www.readbyqxmd.com/read/21196370/calcium-fructoborate-plant-based-dietary-boron-as-potential-medicine-for-cancer-therapy
#12
REVIEW
Ion Romulus Scorei
It was predicted that more B-containing molecules will be discovered that will prove useful in applications involving cell surface signaling, but insufficient progress was made in this general direction. The main objective of this review is to reveal other promising research directions for B-chemoprevention and chemotherapy using Calcium Fructoborate (CF). Targets include breast cancer, prostate cancer, lung cancer and cervical cancer. CF has been identified as Ca ( (C6H10O6)2B)2o4H2O and is a natural product from plants (can be produced by chemical synthesis as well), and is efficient in the prevention and treatments (as adjuvant) of osteoporosis and osteoarthritis...
2011: Frontiers in Bioscience (Scholar Edition)
https://www.readbyqxmd.com/read/19669712/in-vitro-effects-of-calcium-fructoborate-upon-production-of-inflammatory-mediators-by-lps-stimulated-raw-264-7-macrophages
#13
Romulus Ion Scorei, Cristina Ciofrangeanu, Raluca Ion, Anisoara Cimpean, Bianca Galateanu, Valentina Mitran, Dana Iordachescu
The present study is supported by our previous findings suggesting that calcium fructoborate (CF) has anti-inflammatory and antioxidant properties. Thus, we investigated the effects of CF on a model for studying inflammatory disorders in vitro represented by lipopolysaccharide (LPS)-stimulated murine macrophage RAW 264.7 cells. This investigation was performed by analyzing the levels of some mediators released during the inflammatory process: cytokines such as tumor necrosis factor-alpha (TNF-alpha), interleukins IL-1beta and IL-6 as well as cyclooxygenase-2 (COX-2), the main enzyme responsible for endotoxin/LPS-induced prostaglandin synthesis by macrophages...
June 2010: Biological Trace Element Research
https://www.readbyqxmd.com/read/18227977/experimental-and-theoretical-studies-of-calcium-fructoborate
#14
C C Wagner, V Ferraresi Curotto, R Pis Diez, E J Baran
Calcium fructoborate samples of composition Ca(C6H10O6BO)2 x 3 x 5H2O were characterized by chemical analysis, infrared and Raman spectroscopy, and thermoanalytical (thermogravimetric and differential thermal analysis) data. Theoretical studies, using density functional theory, were made for seven different structural models of the fructoborate moiety, and the most stable structure could be derived from these calculations. The results of the theoretical study also allow improving the assignment of the vibrational spectra of the compound...
April 2008: Biological Trace Element Research
https://www.readbyqxmd.com/read/18176783/comparative-effects-of-boric-acid-and-calcium-fructoborate-on-breast-cancer-cells
#15
COMPARATIVE STUDY
R Scorei, Raluca Ciubar, Cristina M Ciofrangeanu, Valentina Mitran, Anisoara Cimpean, Dana Iordachescu
Recent studies suggested that boron has a chemo-preventive role in prostate cancer. In the present report, we investigated the effects of calcium fructoborate (CF) and boric acid (BA) on activation of the apoptotic pathway in MDA-MB-231 human breast cancer cells. Exposure to BA and CF inhibited the proliferation of breast cancer cells in a dose-dependent manner. Treatment with CF but not BA resulted in a decrease in p53 and bcl-2 protein levels. Furthermore, after the treatment with CF, augmentation of pro-caspase-3 protein expression, cytosolic cytochrome c level, and caspase-3 activity were observed, indicating apoptotic cell death induction...
June 2008: Biological Trace Element Research
https://www.readbyqxmd.com/read/17848728/in-vitro-effects-of-calcium-fructoborate-on-fmlp-stimulated-human-neutrophil-granulocytes
#16
R Scorei, Raluca Ciubar, Cristina Iancu, Valentina Mitran, Anisoara Cimpean, Dana Iordachescu
Discovery of naturally occurring boron complexes with organic compounds containing hydroxyl groups, sugars, and polysaccharides, adenosine-5-phosphate, pyridoxine, riboflavin, dehydroascorbic acid, and pyridine nucleotides led to the reassessment of the biochemical role of boron. Boron's anti-inflammatory actions were claimed but not yet demonstrated. This study investigated the effects of calcium fructoborate (CF) on the human polymorphonuclear neutrophils (PMN) that play a central role in the inflammatory response...
July 2007: Biological Trace Element Research
https://www.readbyqxmd.com/read/16217137/in-vitro-evaluation-of-the-antioxidant-activity-of-calcium-fructoborate
#17
R Scorei, V M Cimpoiasu, Dana Iordachescu
Although increasing evidence shows the nutritional benefits of calcium fructoborate (CF) on animals and humans, its action mechanism has not been clearly identified. The present study aims to investigate the possible antioxidant function of CF. Based on its efficiency in skin wound healing, the authors tested whether CF possesses antioxidant properties on human keratinocytes cultures, in a complete serum-free medium (KMK-2; Sigma). The cells treated with CF (0-450 nmol/culture medium) were exposed to exogenous 100 micromol of hydrogen peroxide to mimic the oxidative stress...
November 2005: Biological Trace Element Research
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