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Dominic C Marshall, Justin D Salciccioli, Ross J Goodson, Marco A Pimentel, Kristi Y Sun, Leo Anthony Celi, Joseph Shalhoub
PURPOSE: Serum sodium derangement is the most common electrolyte disturbance among patients admitted to intensive care. This study aims to validate the association between dysnatremia and serum sodium fluctuation with mortality in surgical intensive care patients. METHOD: We performed a retrospective analysis of the Medical Information Mart for Intensive Care II database. Dysnatremia was defined as a sodium concentration outside physiologic range (135-145mmol/L) and subjects were categorized by severity of dysnatremia and sodium fluctuation...
February 13, 2017: Journal of Critical Care
Edson A Nicolini, Roosevelt S Nunes, Gabriela V Santos, Silvana Lia da Silva, Mariana M Carreira, Fernanda G Pellison, Mayra G Menegueti, Maria Auxiliadora-Martins, Fernando Bellissimo-Rodrigues, Marcus A Feres, Anibal Basile-Filho
Several studies have demonstrated the impact of dysnatremias on mortality of intensive care unit (ICU) patients. The objective of this study was to assess whether dysnatremia is an independent factor to predict mortality in surgical critically ill patients admitted to ICU in postoperative phase.One thousand five hundred and ninety-nine surgical patients (58.8% males; mean age of 60.6 ± 14.4 years) admitted to the ICU in the postoperative period were retrospectively studied. The patients were classified according to their serum sodium levels (mmol/L) at admission as normonatremia (135-145), hyponatremia (<135), and hypernatremia (>145)...
March 2017: Medicine (Baltimore)
Rik H G Olde Engberink, Nienke M G Rorije, Bert-Jan H van den Born, Liffert Vogt
The assumption that sodium accumulation in the human body is always accompanied by water retention has been challenged by data showing that sodium can be stored nonosmotically. Here we investigated the contribution of nonosmotic sodium storage to short-term sodium homeostasis after hypertonic saline infusion in healthy individuals on a low-sodium diet. During four hours after infusion, we compared the observed changes in plasma sodium concentration and urinary cation excretion with changes that were calculated with the Adrogue-Madias and Nguyen-Kurtz formula, formulations widely implemented to guide the treatment of dysnatremias...
January 26, 2017: Kidney International
Julien Guillaumin, Stephen P DiBartola
This review article discusses normal and abnormal sodium balance in small animals. The terms and concepts central to understanding normal sodium and water balance are presented as well as of the physiology of body fluid compartments and the movement of fluid between those compartments. As dysnatremia is a very common disorder across the spectrum of critically ill patients, the main focus of the article is to present several clinical examples of both acute and chronic hypernatremia and hyponatremia and their practical, clinical management...
March 2017: Veterinary Clinics of North America. Small Animal Practice
Abdul Hai, Nadeem Kizilbash
OBJECTIVE: The aim of this study was to test the action of Porphyrin compounds, Tetraphenylporphine sulfonate (TPPS), 5,10,15,20-Tetrakis (4-sulfonatophenyl) porphyrinato Iron(III) Chloride (FeTPPS) and 5,10,15,20-Tetrakis (4-sulfonatophenyl) porphyrinato Iron(III) nitrosyl Chloride (FeNOTPPS), on Na+, K+ -ATPase of cell membrane of erythrocytes. METHODS: Enzymatic assays, measuring the amount of inorganic phosphate produced, were used to estimate the activity of Na(+), K(+)-ATPase...
September 2016: Pakistan Journal of Medical Sciences Quarterly
Jon Kaufman, Daniel Phadke, Suhong Tong, Jennifer Eshelman, Sarah Newman, Christopher Ruzas, Eduardo M da Cruz, Suzanne Osorio
Dysnatremias (DN) are common electrolyte disturbances in cardiac critical illness and are known risk factors for adverse outcomes in certain populations. Little information exists on DN in children with cardiac disease admitted to the cardiac intensive care unit (CICU) after undergoing cardiac surgery, either corrective or palliative. The aim was to determine the incidence and adverse outcomes associated with DN in neonates and infants undergoing cardiac surgery. Retrospective cohort and single center study performed at Children's Hospital Colorado from May 2013 to May 2014, in children under 1 year old admitted to the CICU after undergoing surgery for congenital or acquired cardiac disease...
January 2017: Pediatric Cardiology
Vishnu K, Ravishankar Ag
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Kioomars Golshekan, Hamidreza Badeli, Mahboube Miri, Maryam Mirzaie, Afagh Hassanzadeh Rad, Fatemeh Salamat, Sepideh Abdi Tazeabadi, Nahid Bidar, Kobra Blouki-Moghaddam, Houman Hashemian
INTRODUCTION: Gastroenteritis (GE) is one of the most common pediatric diseases. Hyponatremia commonly occurs by administering hypotonic fluids to GE and hospitalized children. Yet, there is no consensus on the ideal method of treatment. OBJECTIVES: we aimed to assess suitable intravenous (IV) fluid for preventing dysnatremia in children with GE. PATIENTS AND METHODS: This is a double blind randomized clinical trial, which was conducted on infants of 6 months up to 14 years children with GE...
2016: Journal of Renal Injury Prevention
Vanessa A Ravel, Elani Streja, Rajnish Mehrotra, John J Sim, Kevin Harley, Juan Carlos Ayus, Alpesh N Amin, Steven M Brunelli, Csaba P Kovesdy, Kamyar Kalantar-Zadeh, Connie M Rhee
BACKGROUND: Sodium disarrays are common in peritoneal dialysis (PD) patients, and may be associated with adverse outcomes in this population. However, few studies of limited sample size have examined the association of serum sodium with mortality in PD patients, with inconsistent results. We hypothesized that both hypo- and hypernatremia are associated with higher death risk in a nationally representative cohort of US PD patients. METHODS: We sought to examine the association of serum sodium over time and mortality among 4687 adult incident PD patients from a large US dialysis organization who underwent one or more serum sodium measurements within the first 3 months of dialysis over January 2007 to December 2011...
June 29, 2016: Nephrology, Dialysis, Transplantation
Amanda J Miller, Olga Theou, Miranda McMillan, Susan E Howlett, Karthik K Tennankore, Kenneth Rockwood
Background: Frailty represents an age-related state of increased risk of adverse health outcomes, reflecting some combination of increased damage and compromised repair processes. Our objectives were to establish whether frailty is associated with dysnatremia (a deviation of serum sodium from normal values), to determine whether frailty explains the previously established association between age and dysnatremia and to assay the impact of each on mortality. Methods: The relationship between age, frailty, and dysnatremia was investigated across the adult life course in 8,911 respondents from the 2003-2004 and 2005-2006 cross-sectional National Health and Nutrition Examination Survey, on whom both laboratory and mortality data were available...
March 1, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Minhtri K Nguyen, Dai-Scott Nguyen, Minh-Kevin Nguyen
Because changes in the plasma water sodium concentration ([Na(+)]pw) are clinically due to changes in the mass balance of Na(+), K(+), and H2O, the analysis and treatment of the dysnatremias are dependent on the validity of the Edelman equation in defining the quantitative interrelationship between the [Na(+)]pw and the total exchangeable sodium (Nae), total exchangeable potassium (Ke), and total body water (TBW) (Edelman IS, Leibman J, O'Meara MP, Birkenfeld LW. J Clin Invest 37: 1236-1256, 1958): [Na(+)]pw = 1...
September 1, 2016: American Journal of Physiology. Renal Physiology
Haiquan Huang, Stacey E Jolly, Medha Airy, Susana Arrigain, Jesse D Schold, Joseph V Nally, Sankar D Navaneethan
BACKGROUND: Hyponatremia and hypernatremia are associated with death in the general population and those with chronic kidney disease (CKD). We studied the associations between dysnatremias, all-cause mortality and causes of death in a large cohort of Stage 3 and 4 CKD patients. METHODS: We included 45 333 patients with Stage 3 and 4 CKDs followed in a large healthcare system. Associations between hyponatremia (<136 mmol/L) and hypernatremia (>145), and all-cause mortality and causes of death (cardiovascular, malignancy related and non-cardiovascular/non-malignancy related) were studied using Cox proportional hazards and competing risk models...
May 24, 2016: Nephrology, Dialysis, Transplantation
Raymond A Jean, Matthew R DeLuzio, Alexander I Kraev, Gongyi Wang, Daniel J Boffa, Frank C Detterbeck, Zuoheng Wang, Anthony W Kim
BACKGROUND: Our goal was to develop a predictive model that identifies how preoperative risk factors and perioperative complications lead to mortality after anatomic pulmonary resections. STUDY DESIGN: This was a retrospective cohort study. The American College of Surgeons NSQIP database was examined for all patients undergoing elective lobectomies for cancer from 2005 through 2012. Fifty-eight pre- and intraoperative risk factors and 13 complications were considered for their impact on perioperative mortality within 30 days of surgery...
June 2016: Journal of the American College of Surgeons
Shintaro Mandai, Eiichiro Kanda, Soichiro Iimori, Shotaro Naito, Yumi Noda, Hiroaki Kikuchi, Masanobu Akazawa, Katsuyuki Oi, Takayuki Toda, Eisei Sohara, Tomokazu Okado, Sei Sasaki, Tatemitsu Rai, Shinichi Uchida
BACKGROUND: Electrolyte abnormalities, particularly dysnatremia, are independent predictors of adverse outcome in individuals with and without renal failure. However, the association of serum chloride level (Cl(-)) with mortality or risk of cardiovascular (CV) events in chronic kidney disease (CKD) remains unclear. METHODS: This prospective cohort study included 923 pre-dialysis CKD G2-G5 patients among the participants of the CKD Research of Outcomes in Treatment and Epidemiology (CKD-ROUTE) study, who newly visited 16 nephrology centers...
April 4, 2016: Clinical and Experimental Nephrology
Annemieke Oude Lansink-Hartgring, Lara Hessels, Joachim Weigel, Anne Marie G A de Smet, Diederik Gommers, Prashant V Nannan Panday, Ewout J Hoorn, Maarten W Nijsten
BACKGROUND: Dysnatremia is associated with adverse outcome in critically ill patients. Changes in patients or treatment strategies may have affected the incidence of dysnatremia over time. We investigated long-term changes in the incidence of dysnatremia and analyzed its association with mortality. METHODS: Over a 21-year period (1992-2012), all serum sodium measurements were analyzed retrospectively in two university hospital ICUs, up to day 28 of ICU admission for the presence of dysnatremia...
December 2016: Annals of Intensive Care
Anibal Basile-Filho, Mayra Goncalves Menegueti, Edson Antonio Nicolini, Alessandra Fabiane Lago, Edson Zangiacomi Martinez, Maria Auxiliadora-Martins
BACKGROUD: The dysnatremias (hyponatremia and hypernatremia) are relatively common findings on admission of intensive care unit (ICU) patients and may represent a major risk. The aim of the study was to assess the ability of serum sodium levels and the Acute Physiology and Chronic Health Evaluation II (APACHE II) to predict mortality of surgical critically ill patients. METHODS: One hundred and ninety-five surgical patients (62% males and 38% females; mean age of 51...
February 2016: Journal of Clinical Medicine Research
Renata S Mendes, Márcio Soares, Carla Valente, José Hermógenes Suassuna, Eduardo Rocha, Elizabeth R Maccariello
BACKGROUND AND OBJECTIVES: The present study aimed to evaluate the prognostic impact of predialysis dysnatremia in patients with acute kidney injury requiring renal replacement therapy (RRT). DESIGN, SETTING, PARTICIPANTS, AND MEASUREMENTS: A secondary analysis of a prospective multicenter cohort study was performed. Serum sodium (Na) concentrations were categorized immediately before the first RRT as normonatremia (135≤Na ≤145mEq/L), hyponatremia (mild [130≤Na ≤134mEq/L] or severe [Na ≤129mEq/L]), and hypernatremia (mild [146≤Na ≤155mEq/L] or severe [Na ≥156mEq/L])...
October 2015: Journal of Critical Care
Kiyoko Bito, Satoshi Higuchi, Azusa Omura, Yuri Kaneda, Reiko Otaki, Satomi Azuma, Mikiko Kojima, Naoki Otsuka, Kenji Shida, Kazumasa Yasumoto
BACKGROUND: This study was designed to evaluate the effects of perioperative administration of an isotonic electrolyte solution with 1% glucose (IT) on blood sodium (Na+) and blood glucose (BG) concentrations in pediatric patients < 1-year-old undergoing plastic surgery in comparison with a conventional hypotonic electrolyte solution with 2.6% glucose (HT). METHODS: Fifty Patients were randomly allocated to HT group and IT group. Na+ and BG were measured at induction of anesthesia (Tind), the end of surgery (Tend), and 4 hours after surgery (T4h)...
March 2015: Masui. the Japanese Journal of Anesthesiology
Enrique Ályarez L, Emilia González C
Dysnatremia is among the most common electrolyte disorders in clinical medicine and its improper management can have serious consequences associated with increased morbidity and mortality of patients. The aim of this study is to update the pathophysiology of dysnatremia and review some simple clinical and laboratory tools, easy to interpret, that allow us to make a quick and simple approach. Dysnatremia involves water balance disorders. Water balance is directly related to osmoregulation. There are mechanisms to maintain plasma osmolality control; which are triggered by 1-2% changes...
June 2014: Revista Chilena de Pediatría
Alice L Fante, Josiane C S Maia, Werther Brunow de Carvalho, Artur F Delgado
No abstract text is available yet for this article.
February 2015: Pediatric Critical Care Medicine
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