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Vishnu K, Ravishankar Ag
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Kioomars Golshekan, Hamidreza Badeli, Mahboube Miri, Maryam Mirzaie, Afagh Hassanzadeh Rad, Fatemeh Salamat, Sepideh Abdi Tazeabadi, Nahid Bidar, Kobra Blouki-Moghaddam, Houman Hashemian
INTRODUCTION: Gastroenteritis (GE) is one of the most common pediatric diseases. Hyponatremia commonly occurs by administering hypotonic fluids to GE and hospitalized children. Yet, there is no consensus on the ideal method of treatment. OBJECTIVES: we aimed to assess suitable intravenous (IV) fluid for preventing dysnatremia in children with GE. PATIENTS AND METHODS: This is a double blind randomized clinical trial, which was conducted on infants of 6 months up to 14 years children with GE...
2016: Journal of Renal Injury Prevention
Vanessa A Ravel, Elani Streja, Rajnish Mehrotra, John J Sim, Kevin Harley, Juan Carlos Ayus, Alpesh N Amin, Steven M Brunelli, Csaba P Kovesdy, Kamyar Kalantar-Zadeh, Connie M Rhee
BACKGROUND: Sodium disarrays are common in peritoneal dialysis (PD) patients, and may be associated with adverse outcomes in this population. However, few studies of limited sample size have examined the association of serum sodium with mortality in PD patients, with inconsistent results. We hypothesized that both hypo- and hypernatremia are associated with higher death risk in a nationally representative cohort of US PD patients. METHODS: We sought to examine the association of serum sodium over time and mortality among 4687 adult incident PD patients from a large US dialysis organization who underwent one or more serum sodium measurements within the first 3 months of dialysis over January 2007 to December 2011...
June 29, 2016: Nephrology, Dialysis, Transplantation
Amanda J Miller, Olga Theou, Miranda McMillan, Susan E Howlett, Karthik K Tennankore, Kenneth Rockwood
BACKGROUND: Frailty represents an age-related state of increased risk of adverse health outcomes, reflecting some combination of increased damage and compromised repair processes. Our objectives were to establish whether frailty is associated with dysnatremia (a deviation of serum sodium from normal values), to determine whether frailty explains the previously established association between age and dysnatremia and to assay the impact of each on mortality. METHODS: The relationship between age, frailty, and dysnatremia was investigated across the adult life course in 8,911 respondents from the 2003-2004 and 2005-2006 cross-sectional National Health and Nutrition Examination Survey, on whom both laboratory and mortality data were available...
June 29, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Minhtri K Nguyen, Dai-Scott Nguyen, Minh-Kevin Nguyen
Because changes in the plasma water sodium concentration ([Na(+)]pw) are clinically due to changes in the mass balance of Na(+), K(+), and H2O, the analysis and treatment of the dysnatremias are dependent on the validity of the Edelman equation in defining the quantitative interrelationship between the [Na(+)]pw and the total exchangeable sodium (Nae), total exchangeable potassium (Ke), and total body water (TBW) (Edelman IS, Leibman J, O'Meara MP, Birkenfeld LW. J Clin Invest 37: 1236-1256, 1958): [Na(+)]pw = 1...
September 1, 2016: American Journal of Physiology. Renal Physiology
Haiquan Huang, Stacey E Jolly, Medha Airy, Susana Arrigain, Jesse D Schold, Joseph V Nally, Sankar D Navaneethan
BACKGROUND: Hyponatremia and hypernatremia are associated with death in the general population and those with chronic kidney disease (CKD). We studied the associations between dysnatremias, all-cause mortality and causes of death in a large cohort of Stage 3 and 4 CKD patients. METHODS: We included 45 333 patients with Stage 3 and 4 CKDs followed in a large healthcare system. Associations between hyponatremia (<136 mmol/L) and hypernatremia (>145), and all-cause mortality and causes of death (cardiovascular, malignancy related and non-cardiovascular/non-malignancy related) were studied using Cox proportional hazards and competing risk models...
May 24, 2016: Nephrology, Dialysis, Transplantation
Raymond A Jean, Matthew R DeLuzio, Alexander I Kraev, Gongyi Wang, Daniel J Boffa, Frank C Detterbeck, Zuoheng Wang, Anthony W Kim
BACKGROUND: Our goal was to develop a predictive model that identifies how preoperative risk factors and perioperative complications lead to mortality after anatomic pulmonary resections. STUDY DESIGN: This was a retrospective cohort study. The American College of Surgeons NSQIP database was examined for all patients undergoing elective lobectomies for cancer from 2005 through 2012. Fifty-eight pre- and intraoperative risk factors and 13 complications were considered for their impact on perioperative mortality within 30 days of surgery...
June 2016: Journal of the American College of Surgeons
Shintaro Mandai, Eiichiro Kanda, Soichiro Iimori, Shotaro Naito, Yumi Noda, Hiroaki Kikuchi, Masanobu Akazawa, Katsuyuki Oi, Takayuki Toda, Eisei Sohara, Tomokazu Okado, Sei Sasaki, Tatemitsu Rai, Shinichi Uchida
BACKGROUND: Electrolyte abnormalities, particularly dysnatremia, are independent predictors of adverse outcome in individuals with and without renal failure. However, the association of serum chloride level (Cl(-)) with mortality or risk of cardiovascular (CV) events in chronic kidney disease (CKD) remains unclear. METHODS: This prospective cohort study included 923 pre-dialysis CKD G2-G5 patients among the participants of the CKD Research of Outcomes in Treatment and Epidemiology (CKD-ROUTE) study, who newly visited 16 nephrology centers...
April 4, 2016: Clinical and Experimental Nephrology
Annemieke Oude Lansink-Hartgring, Lara Hessels, Joachim Weigel, Anne Marie G A de Smet, Diederik Gommers, Prashant V Nannan Panday, Ewout J Hoorn, Maarten W Nijsten
BACKGROUND: Dysnatremia is associated with adverse outcome in critically ill patients. Changes in patients or treatment strategies may have affected the incidence of dysnatremia over time. We investigated long-term changes in the incidence of dysnatremia and analyzed its association with mortality. METHODS: Over a 21-year period (1992-2012), all serum sodium measurements were analyzed retrospectively in two university hospital ICUs, up to day 28 of ICU admission for the presence of dysnatremia...
December 2016: Annals of Intensive Care
Anibal Basile-Filho, Mayra Goncalves Menegueti, Edson Antonio Nicolini, Alessandra Fabiane Lago, Edson Zangiacomi Martinez, Maria Auxiliadora-Martins
BACKGROUD: The dysnatremias (hyponatremia and hypernatremia) are relatively common findings on admission of intensive care unit (ICU) patients and may represent a major risk. The aim of the study was to assess the ability of serum sodium levels and the Acute Physiology and Chronic Health Evaluation II (APACHE II) to predict mortality of surgical critically ill patients. METHODS: One hundred and ninety-five surgical patients (62% males and 38% females; mean age of 51...
February 2016: Journal of Clinical Medicine Research
Renata S Mendes, Márcio Soares, Carla Valente, José Hermógenes Suassuna, Eduardo Rocha, Elizabeth R Maccariello
BACKGROUND AND OBJECTIVES: The present study aimed to evaluate the prognostic impact of predialysis dysnatremia in patients with acute kidney injury requiring renal replacement therapy (RRT). DESIGN, SETTING, PARTICIPANTS, AND MEASUREMENTS: A secondary analysis of a prospective multicenter cohort study was performed. Serum sodium (Na) concentrations were categorized immediately before the first RRT as normonatremia (135≤Na ≤145mEq/L), hyponatremia (mild [130≤Na ≤134mEq/L] or severe [Na ≤129mEq/L]), and hypernatremia (mild [146≤Na ≤155mEq/L] or severe [Na ≥156mEq/L])...
October 2015: Journal of Critical Care
Kiyoko Bito, Satoshi Higuchi, Azusa Omura, Yuri Kaneda, Reiko Otaki, Satomi Azuma, Mikiko Kojima, Naoki Otsuka, Kenji Shida, Kazumasa Yasumoto
BACKGROUND: This study was designed to evaluate the effects of perioperative administration of an isotonic electrolyte solution with 1% glucose (IT) on blood sodium (Na+) and blood glucose (BG) concentrations in pediatric patients < 1-year-old undergoing plastic surgery in comparison with a conventional hypotonic electrolyte solution with 2.6% glucose (HT). METHODS: Fifty Patients were randomly allocated to HT group and IT group. Na+ and BG were measured at induction of anesthesia (Tind), the end of surgery (Tend), and 4 hours after surgery (T4h)...
March 2015: Masui. the Japanese Journal of Anesthesiology
Enrique Ályarez L, Emilia González C
Dysnatremia is among the most common electrolyte disorders in clinical medicine and its improper management can have serious consequences associated with increased morbidity and mortality of patients. The aim of this study is to update the pathophysiology of dysnatremia and review some simple clinical and laboratory tools, easy to interpret, that allow us to make a quick and simple approach. Dysnatremia involves water balance disorders. Water balance is directly related to osmoregulation. There are mechanisms to maintain plasma osmolality control; which are triggered by 1-2% changes...
June 2014: Revista Chilena de Pediatría
Alice L Fante, Josiane C S Maia, Werther Brunow de Carvalho, Artur F Delgado
No abstract text is available yet for this article.
February 2015: Pediatric Critical Care Medicine
George S Pazhayattil, Asghar Rastegar, Ursula C Brewster
Hyponatremia is the most commonly encountered electrolyte abnormality. Severe hyponatremia in pregnancy poses diagnostic and therapeutic challenges. Pregnancy involves changes in physiology that affect water and sodium homeostasis. Knowledge of these complex physiologic alterations during pregnancy is critical to managing dysnatremias in pregnancy. This teaching case describes a woman with chronic hyponatremia who presented during pregnancy with worsening hyponatremia. She had an activating vasopressin receptor mutation, which was passed on to her child, and her diagnostic workup is described...
April 2015: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Vera Spatenkova, Ondrej Bradac, Pavel Skrabalek
BACKGROUND: Dysnatremias are common and prognostically serious in neurocritical care. We studied whether a standardized sodium protocol would improve our neurocritical care of dysnatremias. METHODS: A 5-year prospective study of a standardized sodium protocol for 1,560 patients admitted with various brain diseases in an adult neurologic-neurosurgical intensive care unit (NNICU) was compared with a 5-year retrospective analysis of 1,440 patients without the sodium protocol...
July 2015: Journal of Neurological Surgery. Part A, Central European Neurosurgery
Yun-Zhou Zhang, Jing-Yuan Qie, Qing-Hong Zhang
BACKGROUND: Dysnatremia, which is associated with increased mortality in general intensive care units (ICU), has not been thoroughly studied in neurologic ICU (NICU). METHODS: Prevalence of dysnatremia was retrospectively assessed. The multivariable binary logistic regression model was used to determine the influence of dysnatremia on mortality. RESULTS: Of 519 patients, 106 (20.4%) were admitted with hyponatremia and 177 (34.10%) with hypernatremia...
2015: European Neurology
Alexis A Topjian, Amber Stuart, Alyssa A Pabalan, Ashleigh Clair, Todd J Kilbaugh, Nicholas S Abend, Phillip B Storm, Robert A Berg, Jimmy W Huh, Stuart H Friess
OBJECTIVES: Dysnatremia is common in critically ill children due to disruption of hormonal homeostasis. Children with brain injury are at risk for syndrome of inappropriate antidiuretic hormone, cerebral salt wasting, and sodium losses due to externalized ventricular drain placement. We hypothesized that among PICU patients managed with an externalized ventricular drain, hyponatremia is common, hyponatremia is associated with seizures and in-hospital mortality, and greater sodium fluctuations are associated with in-hospital mortality...
November 2014: Pediatric Critical Care Medicine
Shailesh Bihari, Sandra L Peake, Michael Bailey, David Pilcher, Shivesh Prakash, Andrew Bersten
BACKGROUND: Because increased serum osmolarity may be lung protective, we hypothesized that increased mortality associated with increased serum sodium would be ameliorated in critically ill patients with an acute respiratory diagnosis. METHODS: Data collected within the first 24 hours of intensive care unit (ICU) admission were accessed using ANZICS CORE database. From January 2000 to December 2010, 436,209 patients were assessed. Predefined subgroups including patients with acute respiratory diagnoses were examined...
December 2014: Journal of Critical Care
Stacey R Byers, Andrea S Lear, David C Van Metre
The dysnatremias are defined as abnormalities in serum sodium concentration. Depending on the magnitude and duration of the sodium abnormality and the nature of any concurrent or primary disease, hypernatremia and hypernatremia may result in no consequences, subclinical impairment of health and productivity, or severe clinical disease. Dysnatremias can be the sequelae to diseases or environmental conditions that promote fluid gain or loss from the body, as well as medical interventions that add excessive amounts of sodium or water to the extracellular fluid...
July 2014: Veterinary Clinics of North America. Food Animal Practice
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