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https://www.readbyqxmd.com/read/28811619/comparative-mitogenomic-analysis-of-aposthonia-borneensis-and-aposthonia-japonica-embioptera-oligotomidae-reveals-divergent-evolution-of-webspinners
#1
Zhi-Teng Chen, Liang Lü, Ming-Xing Lu, Yu-Zhou Du
In this study, we report the complete mitochondrial genome (mitogenome, mtDNA) of Aposthonia borneensis and compare it with another sequenced webspinner, Aposthonia japonica. The A. borneensis mitogenome is smaller than A. japonica, but the size of each gene and the A + T content of protein-coding genes (PCGs) are almost identical in the two mitogenomes. Among the PCGs, atp6 shows the highest evolutionary rate and cox1 the lowest. The mtDNA map in A. borneensis is similar to Drosophila yakuba, but distinctly different from A...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28804665/management-of-traumatic-cataract-with-posterior-capsular-rupture-a-case-report-and-in-vitro-model-study
#2
Wenjuan Wan, Ke Hu, Yan Ji, Can Li
PURPOSE: To investigate the optimal strategy for surgical management of traumatic cataract with posterior capsular rupture. METHODS: We describe four cases of traumatic cataract with posterior capsular rupture and an in vitro model built to evaluate the optimal infusion pressure during surgery. RESULTS: All patients underwent cataract surgery. By using an anterior chamber maintainer to elevate infusion pressure, we safely performed cataract extraction without phacoemulsification...
2017: Case Reports in Ophthalmological Medicine
https://www.readbyqxmd.com/read/28790802/the-signs-of-ocular-surface-disorders-after-switching-from-latanoprost-to-tafluprost-timolol-fixed-combination-a-prospective-study
#3
Hideaki Okumichi, Yoshiaki Kiuchi, Tetsuya Baba, Takashi Kanamoto, Tomoko Naito, Shunsuke Nakakura, Hitoshi Tabuchi, Hiroki Nii, Chie Sueoka, Yosuke Sugimoto
PURPOSE: To evaluate the ocular-surface safety of a 0.001% benzalkonium chloride-containing tafluprost/timolol fixed combination (TTFC) in patients with primary open-angle glaucoma (POAG) or ocular hypertension who have inadequate intraocular pressure (IOP) control with latanoprost monotherapy. METHODS: This study is a multicenter, prospective, single-arm, open-label clinical study. Patients with POAG or ocular hypertension who have inadequate IOP control with latanoprost monotherapy were considered eligible...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28790800/clinical-utility-of-cyclosporine-csa-ophthalmic-emulsion-0-05-for-symptomatic-relief-in-people-with-chronic-dry-eye-a-review-of-the-literature
#4
REVIEW
Michelle K Rhee, Francis S Mah
To review the literature on the efficacy of cyclosporine (CsA) ophthalmic emulsion 0.05% on symptomatic relief in chronic dry eye disease. There is consistent evidence of objective improvements in chronic dry eye disease (Schirmer score, corneal and interpalpebral dye staining, and tear breakup time) with CsA, but variable results with symptomatic improvement, possibly due to patient tolerance of CsA, similar comforting effect with artificial tears and CsA vehicle, and the inherent subjective nature of symptom monitoring and analysis...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28771505/a-mechanistic-individual-based-model-of-microbial-communities
#5
Pahala Gedara Jayathilake, Prashant Gupta, Bowen Li, Curtis Madsen, Oluwole Oyebamiji, Rebeca González-Cabaleiro, Steve Rushton, Ben Bridgens, David Swailes, Ben Allen, A Stephen McGough, Paolo Zuliani, Irina Dana Ofiteru, Darren Wilkinson, Jinju Chen, Tom Curtis
Accurate predictive modelling of the growth of microbial communities requires the credible representation of the interactions of biological, chemical and mechanical processes. However, although biological and chemical processes are represented in a number of Individual-based Models (IbMs) the interaction of growth and mechanics is limited. Conversely, there are mechanically sophisticated IbMs with only elementary biology and chemistry. This study focuses on addressing these limitations by developing a flexible IbM that can robustly combine the biological, chemical and physical processes that dictate the emergent properties of a wide range of bacterial communities...
2017: PloS One
https://www.readbyqxmd.com/read/28771380/antioxidant-and-osmoprotecting-activity-of-taurine-in-dry-eye-models
#6
Claudio Bucolo, Annamaria Fidilio, Chiara Bianca Maria Platania, Federica Geraci, Francesca Lazzara, Filippo Drago
PURPOSE: To assess the protective effects of ophthalmic formulations based on taurine (TAU) and sodium hyaluronate (SH) in ocular surface. METHODS: Rabbit corneal epithelial cells [Statens Seruminstitut Rabbit Cornea (SIRC)] were subjected to oxidative stress (1 mM H2O2) and treated with the following formulations: 0.2% SH, 0.4% SH, 0.4% SH +0.5% TAU. Reactive oxygen species (ROS) were evaluated by commercial kit. Dry eye was induced by atropine sulfate and topical treatment was carried out with the following formulations: 0...
August 3, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28759302/evaluation-of-clinical-efficacy-and-safety-of-a-novel-cyclosporin-a-nanoemulsion-in-the-treatment-of-dry-eye-syndrome
#7
Hyun Seung Kim, Tae-Im Kim, Jin Hyoung Kim, Kyung Chul Yoon, Joon Young Hyon, Ko Un Shin, Chul Young Choi
PURPOSE: Topical administration of the anti-inflammatory agent cyclosporin A (CsA) is recommended for long-term management of dry eye syndrome (DES), yet standard ophthalmic CsA preparations have been reported to be unstable. In this trial, the efficacy and safety of Clacier™ (based on a phase 3 study developed by Huons Co. Ltd.), a novel 0.05% CsA nanoemulsion formulation, are compared with those of the conventional Restasis(®) emulsion. METHODS: Patients with moderate-to-severe DES were randomly assigned to receive topical 0...
July 31, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28749692/pickering-emulsions-stabilized-by-ph-responsive-microgels-and-their-scalable-transformation-to-robust-sub-micrometer-colloidoisomes-with-selective-permeability
#8
Wenkai Wang, Amir H Milani, Zhengxing Cui, Mingning Zhu, Brian R Saunders
Colloidosomes are micrometer-sized hollow particles that have shells consisting of coagulated or fused colloid particles. Whilst many large colloidosomes with sizes well above 1.0 μm have been prepared there are fewer examples of sub-micrometer colloidosomes. Here, we establish a simple emulsion templating-based method for the preparation of robust sub-micrometer pH-responsive microgel colloidosomes. The colloidosomes are constructed from microgel particles based on ethyl acrylate and methacrylic acid with peripheral vinyl groups...
July 27, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28741424/validity-of-the-breakup-strategies-questionnaire-in-korea-exploratory-structural-equation-modeling-and-rasch-s-modeling
#9
Dong-Gwi Lee, Harim Sohn, Byeong Hoon Bae, Yoorim Song
This study examines the validity of the Korean implementation of the Breakup Strategies Questionnaire. In Study 1, the construct validity of the Breakup Strategies Questionnaire was explored with 292 Korean undergraduate students. Exploratory Structural Equation Modeling and Rasch's Modeling suggest 30 items with four factors (Avoidance/withdrawal, Positive tone/self-blame, Open confrontation, and Indirect manipulation) and five points in response. Study 2 with 174 Korean undergraduate students suggested potential gender differences in breakup strategy dimensions and provided support for concurrent validity with a measure of personal styles of coping as well as discriminant validity with social desirability...
January 1, 2017: Psychological Reports
https://www.readbyqxmd.com/read/28736342/tfos-dews-ii-diagnostic-methodology-report
#10
REVIEW
James S Wolffsohn, Reiko Arita, Robin Chalmers, Ali Djalilian, Murat Dogru, Kathy Dumbleton, Preeya Gupta, Paul Karpecki, Sihem Lazreg, Heiko Pult, Benjamin D Sullivan, Alan Tomlinson, Louis Tong, Edoardo Villani, Kyung Chul Yoon, Lyndon Jones, Jennifer Craig
The role of the Tear Film and Ocular Surface Society (TFOS) Dry Eye Workshop (DEWS) II Diagnostic Methodology Subcommittee was 1) to identify tests used to diagnose and monitor dry eye disease (DED), 2) to identify those most appropriate to fulfil the definition of DED and its sub-classifications, 3) to propose the most appropriate order and technique to conduct these tests in a clinical setting, and 4) to provide a differential diagnosis for DED and distinguish conditions where it is a comorbidity. Symptom screening with the DEQ-5 or OSDI confirms that a patient might have DED and triggers the diagnostic tests of (ideally non-invasive) breakup time, osmolarity and ocular surface staining with fluorescein and lissamine green (observing the cornea, conjunctiva and eyelid margin)...
May 4, 2017: Ocular Surface
https://www.readbyqxmd.com/read/28736338/the-tfos-international-dry-eye-workshop-ii-report-of-the-tear-film-subcommittee
#11
REVIEW
Mark D P Willcox, Pablo Argüeso, Georgi Georgiev, Juha Holopainen, Gordon Laurie, Tom Millar, Eric Papas, Jannick Rolland, Tannin Schmidt, Ulrike Stahl, Tatiana Suarez, Lakshman Subbaraman, Omür Uçakhan, Lyndon Jones
The members of the Tear Film Subcommittee reviewed the role of the tear film in dry eye disease (DED). The Subcommittee reviewed biophysical and biochemical aspects of tears and how these change in DED. Clinically, DED is characterized by loss of tear volume, more rapid breakup of the tear film and increased evaporation of tears from the ocular surface. The tear film is composed of many substances including lipids, proteins, mucins and electrolytes. All of these contribute to the integrity of the tear film but exactly how they interact is still an area of active research...
March 30, 2017: Ocular Surface
https://www.readbyqxmd.com/read/28729507/remobilization-of-crustal-carbon-may-dominate-volcanic-arc-emissions
#12
Emily Mason, Marie Edmonds, Alexandra V Turchyn
The flux of carbon into and out of Earth's surface environment has implications for Earth's climate and habitability. We compiled a global data set for carbon and helium isotopes from volcanic arcs and demonstrated that the carbon isotope composition of mean global volcanic gas is considerably heavier, at -3.8 to -4.6 per mil (‰), than the canonical mid-ocean ridge basalt value of -6.0‰. The largest volcanic emitters outgas carbon with higher δ(13)C and are located in mature continental arcs that have accreted carbonate platforms, indicating that reworking of crustal limestone is an important source of volcanic carbon...
July 21, 2017: Science
https://www.readbyqxmd.com/read/28709343/internal-rupture-and-rapid-bouncing-of-impacting-drops-induced-by-submillimeter-scale-textures
#13
Rui Zhang, Xiwen Zhang, Pengfei Hao, Feng He
We demonstrate an internal breakup mechanism for high Weber number drop impact on superhydrophobic surfaces uniformly patterned with submillimeter-scale textures, in which the liquid film ruptures from both interior and rim. The employment of submillimeter-scale posts could help decrease the critical Weber number of internal rupture, due to the small solid fraction and the large dimension ratio between primary structures and droplets. The internal rupture is found to promote more rapid drop bouncing than conventional rebound and rim breakup on superhydrophobic surfaces with small roughness, with a 10%-50% reduction of contact time...
June 2017: Physical Review. E
https://www.readbyqxmd.com/read/28709223/instability-evolution-of-the-viscous-elliptic-liquid-jet-in-the-rayleigh-regime
#14
Shibo Gu, Lipo Wang, David L S Hung
For jet flow emanating from noncircular orifices, an unbalanced surface tension force leads to capillary instability, which is independent of influence from the ambient air in the Rayleigh regime. In the present article, the dynamic behavior of incompressible elliptical jets in the Rayleigh regime is investigated. Theoretically, with the consideration of the fluid viscosity, the solution of the Cosserat equation consists of a particular solution and a complementary solution. For the complementary solution the wave number of disturbance modes has two complex conjugate roots, which are responsible for the jet breakup...
June 2017: Physical Review. E
https://www.readbyqxmd.com/read/28708816/determination-of-the-minimal-clinically-important-difference-of-the-university-of-north-carolina-dry-eye-management-scale
#15
Christopher J Hwang, Reeves Ellis, Richard M Davis, Sue Tolleson-Rinehart
PURPOSE: To establish an initial estimation of the MCID of the University of North Carolina Dry Eye Management Scale (UNC DEMS) and assess its association with patient perceptions of symptom change. METHODS: Thirty-three patients (33.3% men, 67.7% women, mean age 60.5 yrs) with previous DEMS scores were recruited from a UNC ophthalmology clinic in spring 2014. We used anchor-based methods, categorizing important symptom change, to compare the change in the DEMS scores across visits to patient assessments of change; linear regression coefficients estimated the MCID...
September 2017: Cornea
https://www.readbyqxmd.com/read/28704773/the-influence-of-protruding-filamentous-bacteria-on-floc-stability-and-solid-liquid-separation-in-the-activated-sludge-process
#16
Wilhelm Burger, Konrad Krysiak-Baltyn, Peter J Scales, Gregory J O Martin, Anthony D Stickland, Sally L Gras
Filamentous bacteria can impact on the physical properties of flocs in the activated sludge process assisting solid-liquid separation or inducing problems when bacteria are overabundant. While filamentous bacteria within the flocs are understood to increase floc tensile strength, the relationship between protruding external filaments, dewatering characteristics and floc stability is unclear. Here, a quantitative methodology was applied to determine the abundance of filamentous bacteria in activated sludge samples from four wastewater treatment plants...
June 23, 2017: Water Research
https://www.readbyqxmd.com/read/28699061/hydroxypropyl-methylcellulose-2-for-dry-eye-prevention-during-phacoemulsification-in-senile-and-diabetic-patients
#17
Maierhaba Yusufu, Xin Liu, Tianyu Zheng, Fan Fan, Jianjiang Xu, Yi Luo
PURPOSE: To assess the effect of hydroxypropyl methylcellulose (HPMC) 2% to prevent dry eye during phacoemulsification in senile and diabetic patients. METHODS: This prospective interventional case series comprised 60 eyes (44 patients) with age-related cataract scheduled for standardized phacoemulsification surgery. The patients were assigned to receive either balanced saline solution (BSS, 30 eyes) or HPMC 2% (30 eyes) during surgery. Preoperative and postoperative examinations (1, 3, 7 and 30 days) included measurements of automatic noninvasive tear film breakup time (NITBUT), fluorescein staining, Schirmer I test, tear meniscus height, depth and area and subjective symptoms...
July 11, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28694687/efficacy-and-safety-of-retinol-palmitate-ophthalmic-solution-in-the-treatment-of-dry-eye-a-japanese-phase-ii-clinical-trial
#18
Hiroshi Toshida, Toshinari Funaki, Koichi Ono, Nobuhito Tabuchi, Sota Watanabe, Tamotsu Seki, Hiroshi Otake, Takuji Kato, Nobuyuki Ebihara, Akira Murakami
PURPOSE: The purpose of this study was to investigate the efficacy and safety of the administration of retinol palmitate (VApal) ophthalmic solution (500 IU/mL) for the treatment of patients with dry eye. PATIENTS AND METHODS: This study included 66 patients with dry eye. After a 2-week washout period, patients were randomized (1:1) into either a VApal ophthalmic solution or a placebo group, and a single drop of either solution was administered six times daily for 4 weeks...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28694490/sea-ice-breakup-and-marine-melt-of-a-retreating-tidewater-outlet-glacier-in-northeast-greenland-81%C3%A2-n
#19
Jørgen Bendtsen, John Mortensen, Kunuk Lennert, Jens K Ehn, Wieter Boone, Virginie Galindo, Yu-Bin Hu, Igor A Dmitrenko, Sergei A Kirillov, Kristian K Kjeldsen, Yngve Kristoffersen, David G Barber, Søren Rysgaard
Rising temperatures in the Arctic cause accelerated mass loss from the Greenland Ice Sheet and reduced sea ice cover. Tidewater outlet glaciers represent direct connections between glaciers and the ocean where melt rates at the ice-ocean interface are influenced by ocean temperature and circulation. However, few measurements exist near outlet glaciers from the northern coast towards the Arctic Ocean that has remained nearly permanently ice covered. Here we present hydrographic measurements along the terminus of a major retreating tidewater outlet glacier from Flade Isblink Ice Cap...
July 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28691134/seizure-disorders-and-developmental-disorders-impact-on-life-of-affected-families-a-structured-interview
#20
Ulrike Petra Spindler, Lena Charlott Hotopp, Vivien Angela Bach, Frauke Hornemann, Steffen Syrbe, Anna Andreas, Andreas Merkenschlager, Wieland Kiess, Matthias Karl Bernhard, Thilo Bertsche, Martina Patrizia Neininger, Astrid Bertsche
Seizure disorder and developmental disorder are two of the most common chronic disorders in childhood. Data on perceived parental burden and specific effects on daily life is scarce. We performed a structured interview, consecutively talking to all parents of pediatric outpatients of our university hospital diagnosed with seizure or developmental disorder. Three hundred seven parents (of 317 affected children: 53 with seizure disorder, 44 with specific developmental disorder, 35 with learning disorder, 71 with intellectual disability, 15 with seizure + specific developmental disorder, 23 with seizure + learning disorder, 76 with seizure disorder + intellectual disability) were interviewed...
August 2017: European Journal of Pediatrics
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