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https://www.readbyqxmd.com/read/27769010/secrecy-inhibits-support-a-grounded-theory-of-community-perspectives-of-women-suffering-from-obstetric-fistula-in-kenya
#1
T Lavender, S Wakasiaka, L McGowan, M Moraa, J Omari, W Khisa
AIM: this study aimed to gain understanding of the views of community members in relation to obstetric fistula. DESIGN AND METHOD: a qualitative, grounded theory approach was adopted. Data were collected using in-depth interviews with 45 community members. The constant comparison method enabled generation of codes and subsequent conceptualisations, from the data. SETTING: participants were from communities served by two hospitals in Kenya; Kisii and Kenyatta...
October 4, 2016: Midwifery
https://www.readbyqxmd.com/read/27671523/women-s-and-clinicians-perspectives-of-presentation-with-reduced-fetal-movements-a-qualitative-study
#2
R M D Smyth, W Taylor, A E Heazell, C Furber, M Whitworth, T Lavender
BACKGROUND: Worldwide maternal perception of fetal movements has been used for many years to evaluate fetal wellbeing. It is intuitively regarded as an expression of fetal well-being as pregnancies in which women consistently report regular fetal movements have very low morbidity and mortality. Conversely, maternal perception of reduced fetal movements is associated with adverse pregnancy outcomes. We sought to gain insight into pregnant women's and clinicians views and experiences of reduced movements...
September 26, 2016: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/27560142/thermoregulation-of-meningococcal-fhbp-an-important-virulence-factor-and-vaccine-antigen-is-mediated-by-anti-ribosomal-binding-site-sequences-in-the-open-reading-frame
#3
Edmund Loh, Hayley Lavender, Felicia Tan, Alexander Tracy, Christoph M Tang
During colonisation of the upper respiratory tract, bacteria are exposed to gradients of temperatures. Neisseria meningitidis is often present in the nasopharynx of healthy individuals, yet can occasionally cause severe disseminated disease. The meningococcus can evade the human complement system using a range of strategies that include recruitment of the negative complement regulator, factor H (CFH) via factor H binding protein (fHbp). We have shown previously that fHbp levels are influenced by the ambient temperature, with more fHbp produced at higher temperatures (i...
August 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/25480115/sinbase-an-integrated-database-to-study-genomics-genetics-and-comparative-genomics-in-sesamum-indicum
#4
Linhai Wang, Jingyin Yu, Donghua Li, Xiurong Zhang
Sesame (Sesamum indicum L.) is an ancient and important oilseed crop grown widely in tropical and subtropical areas. It belongs to the gigantic order Lamiales, which includes many well-known or economically important species, such as olive (Olea europaea), leonurus (Leonurus japonicus) and lavender (Lavandula spica), many of which have important pharmacological properties. Despite their importance, genetic and genomic analyses on these species have been insufficient due to a lack of reference genome information...
January 2015: Plant & Cell Physiology
https://www.readbyqxmd.com/read/24902444/code-lavender-initiating-holistic-rapid-response-at-the-cleveland-clinic
#5
Barbie Johnson
No abstract text is available yet for this article.
April 2014: Beginnings: the Official Newsletter of the American Holistic Nurses' Association
https://www.readbyqxmd.com/read/24889233/mice-of-the-resistant-h-2-b-haplotype-mount-broad-cd4-t-cell-responses-against-9-distinct-friend-virus-epitopes
#6
Ronald J Messer, Kerry J Lavender, Kim J Hasenkrug
To date, only a single Friend virus (FV) peptide recognized by CD4(+) T cells in FV-infected mice of the resistant H-2(b) haplotype has been described. To more thoroughly examine the repertoire of CD4(+) T cell responses in H-2(b) mice infected with this retrovirus, 18mer peptides spanning the FV gag, pol, and env coding regions with 11mer overlaps were synthesized. The peptides were then used to stimulate whole splenocytes and purified CD4(+) T cells from FV-infected mice in an IFNγ ELISPOT assay. Nine new CD4(+) T cell epitopes were identified, 3 encoded by gag, 1 by pol, and 5 by env...
May 2014: Virology
https://www.readbyqxmd.com/read/24685653/enhanced-levels-of-s-linalool-by-metabolic-engineering-of-the-terpenoid-pathway-in-spike-lavender-leaves
#7
Isabel Mendoza-Poudereux, Jesús Muñoz-Bertomeu, Alicia Navarro, Isabel Arrillaga, Juan Segura
Transgenic Lavandula latifolia plants overexpressing the linalool synthase (LIS) gene from Clarkia breweri, encoding the LIS enzyme that catalyzes the synthesis of linalool were generated. Most of these plants increased significantly their linalool content as compared to controls, especially in the youngest leaves, where a linalool increase up to a 1000% was observed. The phenotype of increased linalool content observed in young leaves was maintained in those T1 progenies that inherit the LIS transgene, although this phenotype was less evident in the flower essential oil...
May 2014: Metabolic Engineering
https://www.readbyqxmd.com/read/24193010/a-comparison-of-methods-for-egfr-mutation-testing-in-non-small-cell-lung-cancer
#8
MULTICENTER STUDY
Elizabeth C Young, Martina M Owens, Idowu Adebiyi, Tina Bedenham, Rachel Butler, Jonathan Callaway, Treena Cranston, Charlene Crosby, Ian A Cree, Laura Dutton, Catherine Faulkes, Claire Faulkner, Emma Howard, Julia Knight, Yuanxue Huang, Louise Lavender, Lazarus P Lazarou, Hongxiang Liu, Debbie Mair, Antonio Milano, Stacey Sandell, Alison Skinner, Andrew Wallace, Maggie Williams, Vicky Spivey, John Goodall, Jonathan Frampton, Sian Ellard
EGFR mutation testing of tumor samples is routinely performed to predict sensitivity to treatment with tyrosine kinase inhibitors for patients with non-small cell lung cancer. At least 9 different methodologies are employed in UK laboratories, and the aim of this study was to compare the sensitivity of different methods for the detection of EGFR mutations. Participating laboratories were sent coded samples with varying mutation loads (from 0% to 15%) to be tested for the p.Leu858Arg (p.L858R) missense mutation and c...
December 2013: Diagnostic Molecular Pathology: the American Journal of Surgical Pathology, Part B
https://www.readbyqxmd.com/read/23938411/sun-glint-estimation-in-marine-satellite-images-a-comparison-of-results-from-calculation-and-radiative-transfer-modeling
#9
Susan Kay, John Hedley, Samantha Lavender
The intensity and location of Sun glint in two Medium Resolution Imaging Spectrometer (MERIS) images was modeled using a radiative transfer model that includes elevation features as well as the slope of the sea surface. The results are compared to estimates made using glint flagging and correction approaches used within standard atmospheric correction processing code. The model estimate gives a glint pattern with a similar width but lower peak level than any current method, or than that estimated by a radiative transfer model with surfaces that include slope but not height...
August 10, 2013: Applied Optics
https://www.readbyqxmd.com/read/22592779/cloning-functional-characterization-and-genomic-organization-of-1-8-cineole-synthases-from-lavandula
#10
Zerihun A Demissie, Monica A Cella, Lukman S Sarker, Travis J Thompson, Mark R Rheault, Soheil S Mahmoud
Several members of the genus Lavandula produce valuable essential oils (EOs) that are primarily constituted of the low molecular weight isoprenoids, particularly monoterpenes. We isolated over 8,000 ESTs from the glandular trichomes of L. x intermedia flowers (where bulk of the EO is synthesized) to facilitate the discovery of genes that control the biosynthesis of EO constituents. The expression profile of these ESTs in L. x intermedia and its parents L. angustifolia and L. latifolia was established using microarrays...
July 2012: Plant Molecular Biology
https://www.readbyqxmd.com/read/21836155/micrornas-in-lung-diseases
#11
Tom Pagdin, Paul Lavender
The advent of RNA sequencing technology has stimulated rapid advances in our understanding of the transcriptome, including discovery of the vast RNA complement generated by transcript splice variation and the expansion of our knowledge of non-coding RNAs. One non-coding RNA subtype, microRNAs (miRNAs), are particularly well studied, primarily because of their important roles as post-transcriptional gene regulators. The first miRNA was identified in the early 1990s and there are now thought to be around 1000 distinct miRNAs in man, with each cell type expressing a distinct repertoire...
February 2012: Thorax
https://www.readbyqxmd.com/read/21451678/light-transfer-at-the-ocean-surface-modeled-using-high-resolution-sea-surface-realizations
#12
Susan Kay, John Hedley, Samantha Lavender, Alex Nimmo-Smith
The behavior of light at the air-sea interface has been investigated using ray tracing methods with numerically realized surfaces that incorporate features on scales from 3 millimeters to 200 meters. The directional reflection of light at the surface realizations was tested using Monte Carlo code. Estimated directionally reflected radiances were generally in good agreement with those from existing methods that model the slope statistics but not the shape of the sea surface. However, significant differences were found for some incident and exitant directions...
March 28, 2011: Optics Express
https://www.readbyqxmd.com/read/16980564/up-regulation-of-1-deoxy-d-xylulose-5-phosphate-synthase-enhances-production-of-essential-oils-in-transgenic-spike-lavender
#13
Jesús Muñoz-Bertomeu, Isabel Arrillaga, Roc Ros, Juan Segura
Spike lavender (Lavandula latifolia) is an aromatic shrub cultivated worldwide for the production of essential oils. The major constituents of these oils are monoterpenes, which are obtained from isopentenyl diphosphate and dimethylallyl diphosphate precursors through the plastidial methylerythritol phosphate (MEP) pathway and/or the cytosolic mevalonate pathway. 1-Deoxy-D-xylulose-5-P synthase (DXS) catalyzes the first step of the MEP pathway. A cDNA coding for the Arabidopsis (Arabidopsis thaliana) DXS was constitutively expressed in spike lavender...
November 2006: Plant Physiology
https://www.readbyqxmd.com/read/16881927/breastfeeding-and-family-life
#14
Tina Lavender, Catherine McFadden, Lisa Baker
The problems faced by breastfeeding mothers are well documented. However, the influence of social networks has mainly received attention solely through the eyes of the women. Therefore, we explored the views of the family as a whole. This exploratory study utilizes semi-structured interviews, diaries and questionnaires. A purposive sample of 24 women and their families, from a hospital in the north-west of England were invited to participate. Questionnaire data were analysed descriptively. Diaries and interviews were analysed using an open coding mechanism to identify emergent themes...
July 2006: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/15725206/factors-that-influence-women-s-decisions-about-whether-to-participate-in-research-an-exploratory-study
#15
Lisa Baker, Tina Lavender, Douglas Tincello
BACKGROUND: Women are increasingly being asked to consider participating in medical research. We sought to investigate views of women who participated in and declined to participate in a study that was part of a program of maternity care research. METHODS: An exploratory study using focus group interviews and semistructured interviews was conducted. A purposive sample of 17 postnatal women who had participated in research, from a hospital in the North West of England, were interviewed...
March 2005: Birth
https://www.readbyqxmd.com/read/15705799/identification-and-functional-characterization-of-a-novel-27-bp-deletion-in-the-macroglycopeptide-coding-region-of-the-gpiba-gene-resulting-in-platelet-type-von-willebrand-disease
#16
Maha Othman, Colleen Notley, Frances Louise Lavender, Helen White, Christopher D Byrne, David Lillicrap, Denise Frances O'Shaughnessy
Interaction between the platelet glycoprotein Ibalpha (GPIbalpha) receptor and its adhesive ligand von Willebrand factor (VWF) has a critical role in the process of hemostasis. Platelet-type von Willebrand disease (PT-VWD) is a rare bleeding disorder that results from gain-of-function mutations in the GPIBA gene. We studied this gene from 5 members of a previously unreported family with a PT-VWD phenotype. We identified a novel in-frame deletion of 27 base pair (bp) in the macroglycopeptide region. This deletion was not found in the unaffected family members or in 50 healthy controls...
June 1, 2005: Blood
https://www.readbyqxmd.com/read/12874099/x-linked-genes-in-female-embryonic-stem-cells-carry-an-epigenetic-mark-prior-to-the-onset-of-x-inactivation
#17
Laura P O'Neill, Tamzin E Randall, Jayne Lavender, Hugh T Spotswood, Jeannie T Lee, Bryan M Turner
We use chromatin immunoprecipitation to show that genes on the two active X chromosomes in undifferentiated, XX female embryonic stem cells (ES cells) are marked by hyperacetylation of all core histones, hyper(di)methylation of H3 lysine 4 and hypo(di)methylation of H3 lysine 9, compared with autosomal genes or genes on the single active X in XY male cells. The mark is found on both coding and promoter regions. On differentiation, and after the onset of X inactivation, the mark is reversed on the inactive X, whose genes show extreme hypoacetylation of all four core histones, hypo(di)methylation of H3K4 and hyper(di)methylation of H3K9...
August 1, 2003: Human Molecular Genetics
https://www.readbyqxmd.com/read/12091749/the-calming-effect-of-stimuli-presentation-on-infant-japanese-macaques-macaca-fuscata-under-stress-situation-a-preliminary-study
#18
Kiyobumi Kawakami, Masaki Tomonaga, Juri Suzuki
In human newborns, presentation of sounds and odors under stress situations had a calming effect on behavioral and cortisol responses (Kawakami et al., 1996, 1997). These calming effects were examined with 10-day- and 15-day-old Japanese macaques. In Study 1, white noise presentation (Experimental conditions) at the blood sampling was compared with no sound presentation (Control conditions) at the blood sampling. White noise presentation has a calming effect on coded behavioral responses. In Study 2, lavender scent presentation (Experimental conditions) at the blood sampling was compared with no odor presentation (Control conditions) at the blood sampling...
January 2002: Primates; Journal of Primatology
https://www.readbyqxmd.com/read/11376940/the-minisatellite-of-the-gpi-amf-nlk-mf-gene-interspecies-conservation-and-transcriptional-activity
#19
R R Williams, A F Hassan-Walker, F L Lavender, M Morgan, P Faik, J Ragoussis
Minisatellites are tandemly repeated DNA sequences found throughout the genomes of all eukaryotes. They are regions often prone to instability and hence hypervariability; thus repeat unit sequence is generally not conserved beyond closely related species. We have studied the minisatellite located in intron 9 of the human glucose phosphate isomerase (GPI) gene (also known as neuroleukin, autocrine motility factor, maturation and differentiation factor) and have found, by Zoo blotting coupled with PCR amplification and DNA sequencing, that similar repeat units are present in seven other species of mammal...
May 16, 2001: Gene
https://www.readbyqxmd.com/read/8522974/identification-of-evolutionary-conserved-regulatory-sequences-in-the-5-untranscribed-region-of-the-neural-specific-ubiquitin-c-terminal-hydrolase-pgp9-5-gene
#20
COMPARATIVE STUDY
D A Mann, A R Trowern, F L Lavender, P A Whittaker, R J Thompson
The structure at the 5' end of the gene encoding neural-specific protein gene product 9.5 (PGP9.5) has been compared between two evolutionary distant species: the human and Monodelphis domestica. In contrast to the highly conserved coding sequences of the gene, only a 48% identity was found across a 1-kb stretch of 5' untranslated and untranscribed DNA. Promoter function studies performed on the human sequence identified a 233-bp CpG-rich minimal promoter. Truncation mutagenesis revealed the presence of essential positive cis-acting regulatory sequences within the region -182 to -123 relative to the transcription initiation site...
January 1996: Journal of Neurochemistry
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