Khaled M Hosny, Amal M Sindi, Hala M Alkhalidi, Mallesh Kurakula, Nabil K Alruwaili, Nabil A Alhakamy, Walaa A Abualsunun, Rana B Bakhaidar, Rahaf H Bahmdan, Waleed Y Rizg, Sarah A Ali, Wesam H Abdulaal, Majed S Nassar, Mohammed S Alsuabeyl, Adel F Alghaith, Sultan Alshehri
Herpes labialis, caused by herpes simplex virus type 1, is usually characterized by painful skin or mucosal lesions. Penciclovir (PV) tablets are found to be effective against herpes labialis but suffer from poor oral bioavailability. This study aimed to combine the benefits of PV and lavender oil (LO), which exhibits anesthetic activity, in the form of a self-nanoemulsifying drug delivery system (SNEDDS) for the treatment of herpes labialis. Toward this purpose, LO (oil), Labrasol:Labrafil M1944 CS in the ratio of 6:4 (surfactant mixture), and Lauroglycol-FCC (co-surfactant, selected based on the solubility of PV) were evaluated as the independent factors using a distance quadratic mixture design...
December 2021: Drug Delivery