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Anxiety nootropics

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https://www.readbyqxmd.com/read/27868798/neurochemical-and-behavioral-effects-of-nigella-sativa-and-olea-europaea-oil-in-rats
#1
M Atif Raza Cheema, Shazia Nawaz, Sumera Gul, Tabinda Salman, Sabira Naqvi, Ahsana Dar, Darakhshan J Haleem
OBJECTIVES: In the last few decades, therapeutic uses of medicinal compounds present in food as a normal constituent has risen substantially, largely because of their fewer side effects and adequate efficacy. This study is designed to investigate a role of brain serotonin (5-HT) and dopamine (DA) in the potential nootropic, anxiolytic, and other beneficial effects of Nigella sativa (NS) and Olea europaea (OE) oil in rat models. METHODS: Animals were treated with NS and OE oil orally at doses of 0...
November 21, 2016: Nutritional Neuroscience
https://www.readbyqxmd.com/read/27788040/neuropeptide-s-receptor-ligands-a-patent-review-2005-2016
#2
Chiara Ruzza, Girolamo Calò, Salvatore Di Maro, Salvatore Pacifico, Claudio Trapella, Severo Salvadori, Delia Preti, Remo Guerrini
Neuropeptide S (NPS) is a 20-residue peptide and endogenous ligand of the NPS receptor (NPSR). This receptor was a formerly orphan GPCR whose activation increases calcium and cyclic adenosine monophosphate levels. The NPS/NPSR system is expressed in several brain regions where it controls important biological functions including locomotor activity, arousal and sleep, anxiety, food intake, memory, pain, and drug addiction. Areas covered: This review furnishes an updated overview of the patent literature covering NPSR ligands since 2005, when the first example of an NPSR antagonist was disclosed...
November 9, 2016: Expert Opinion on Therapeutic Patents
https://www.readbyqxmd.com/read/27762349/hypericum-perforatum-as-a-cognitive-enhancer-in-rodents-a-meta-analysis
#3
Daniel Ben-Eliezer, Eldad Yechiam
Considered an antidepressant and anti-anxiety agent, Hypericum perforatum affects multiple neurotransmitters in a non-competitive synergistic manner, and may have nootropic potential. We quantitatively reviewed the pre-clinical literature to examine if there is a cognitive-enhancing effect of H. perforatum in healthy rodents. Additionally, within these studies, we compared the effects observed in intact rodents versus those whose performance has been impaired, mostly through stress manipulations. The meta-analysis incorporated studies that examined the effect of H...
October 20, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27754095/os-20-09-diagnosis-and-treatment-of-cognitive-disorders-in-arterial-hypertension
#4
Viktoria Krotova, Tatyana Khomazyuk
OBJECTIVE: One of the first disorders of affection subcortical brain structures in arterial hypertension (AH) is a decrease in mental processes, intellectual rigidity. To investigate the cognitive disorders (CD) in AH patients 1-2 stages of working age and the effectiveness of nootropic agent (phenibutum) and anticholinergic drug (ipidacrinum) in combined antihypertensive therapy. DESIGN AND METHOD: Observed 60 patients with controlled AH 1-2 stages and CD. The median age-55,3 ± 9,1 years and duration of AH-10,2 ± 5,8 years...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27643020/os-20-09-diagnosis-and-treatment-of-cognitive-disorders-in-arterial-hypertension
#5
Viktoria Krotova, Tatyana Khomazyuk
OBJECTIVE: One of the first disorders of affection subcortical brain structures in arterial hypertension (AH) is a decrease in mental processes, intellectual rigidity. To investigate the cognitive disorders (CD) in AH patients 1-2 stages of working age and the effectiveness of nootropic agent (phenibutum) and anticholinergic drug (ipidacrinum) in combined antihypertensive therapy. DESIGN AND METHOD: Observed 60 patients with controlled AH 1-2 stages and CD. The median age-55,3 ± 9,1 years and duration of AH-10,2 ± 5,8 years...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27473605/the-ayurvedic-plant-bacopa-monnieri-inhibits-inflammatory-pathways-in-the-brain
#6
Michelle D Nemetchek, Andrea A Stierle, Donald B Stierle, Diana I Lurie
ETHNOPHARMACOLOGICAL RELEVANCE: Bacopa monnieri (L) Wettst (common name, bacopa) is a medicinal plant used in Ayurveda, the traditional system of medicine of India, as a nootropic. It is considered to be a "medhya rasayana", an herb that sharpens the mind and the intellect. Bacopa is an important ingredient in many Ayurvedic herbal formulations designed to treat conditions such as memory loss, anxiety, poor cognition and loss of concentration. It has also been used in Ayurveda to treat inflammatory conditions such as arthritis...
July 26, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27464742/anxiolytic-activity-of-the-neuroprotective-peptide-hldf-6-and-its-effects-on-brain-neurotransmitter-systems-in-balb-c-and-c57bl-6-mice
#7
Yurii A Zolotarev, Georgii I Kovalev, Natalya V Kost, Margarita E Voevodina, Oleg Y Sokolov, Alexander K Dadayan, Evgenii A Kondrakhin, Ekaterina V Vasileva, Anna P Bogachuk, Vyacheslav N Azev, Valery M Lipkin, Nikolai F Myasoedov
This study is focused on a new amide derivative of the peptide HLDF-6 (Thr-Gly-Glu-Asn-His-Arg). This hexapeptide is a fragment of Human Leukaemia Differentiation Factor (HLDF). It displays a broad range of nootropic and neuroprotective activities. We showed, for the first time, that the peptide HLDF-6-amide has high anxiolytic activity. We used 'open field' and 'elevated plus maze' tests to demonstrate anxiolytic effects of HLDF-6-amide (0.1 and 0.3 mg/kg intranasally), which were comparable to those of the reference drug diazepam (0...
September 2016: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/27296802/-the-efficacy-of-divasa-in-the-early-recovery-period-of-ischemic-stroke
#8
O A Mudrova, N B Shchekolova, F A Borikov
AIM: To evaluate the efficacy of the drug divasa in treatment of cognitive and emotional disorders in patients in the early recovery period of ischemic stroke (IS). MATERIAL AND METHODS: The study included 60 patients, aged from 45 to 64 years, in the early recovery period of IS. The main group (n=30) received divasa in the dose of 2 tablets three times a day for 12 weeks in the combination with standard treatment, patients of the comparison group (n=30) received only standard treatment...
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/27279696/effect-of-withinia-somnifera-and-shilajit-on-alcohol-addiction-in-mice
#9
Priya Bansal, Sugato Banerjee
BACKGROUND: Alcohol addiction is a social problem leading to both loss of health and economic prosperity among addicted individuals. Common properties of anti-addictive compounds include anti-anxiety, anticonvulsants, anti-depressant, and nootropic actions primarily through modulation of gamma-aminobutyric acid (GABA) and serotonergic systems. OBJECTIVE: Here, we screen ashwagandha and shilajit known ethnopharmacologically as nervine tonic and adaptogenic herbs for possible anti-addictive potential...
May 2016: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/26721353/the-anxiolytic-like-activity-of-a-novel-n-cycloalkyl-n-benzoylpiperazine-derivative
#10
Daniel Jan Strub, Kinga Sałat, Tadeusz Librowski, Stanisław Lochyński, Magdalena Gaweł, Adrian Podkowa
BACKGROUND: Anxiety-related disorders are among the most common mental illnesses in the world for which benzodiazepines, buspirone and antidepressant drugs remain the first-line treatment. These drugs have good efficacy but they have numerous disadvantages, such as drug abuse potential, delayed onset of action or tolerance. A literature review reveals that a variety of piperazine derivatives may exhibit interesting pharmacological properties, including anxiolytic-like, antidepressant, nootropic and antinociceptive activities demonstrated in animal models, as well as an antioxidant capacity shown in some in vitro tests...
February 2016: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/26604550/anxiolytic-and-nootropic-activity-of-vetiveria-zizanioides-roots-in-mice
#11
Abhijit M Nirwane, Purnima V Gupta, Jitesh H Shet, Sandeep B Patil
BACKGROUND: Vetiveria zizanioides (VZ) (family: Poaceae), an aromatic plant commonly known as "Vetiver" has been used for various ailments. Concerning the various ailments being listed as the traditional uses of VZ, no mention about anxiety and memory was found. OBJECTIVE: The present study examined the anxiolytic and memory enhancing activity of ethanolic extract of V. zizanioides (EEVZ) dried roots in mice. MATERIALS AND METHODS: Activity of EEVZ was assessed using models of anxiety (elevated plus-maze [EPM], light/dark test, hole board test, marble-burying test) and learning and memory (EPM, passive shock avoidance paradigm)...
July 2015: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/26087584/-individual-approach-to-the-use-of-medications-to-normalize-situational-anxiety-under-the-psycho-emotional-stress
#12
RANDOMIZED CONTROLLED TRIAL
I V Ivanov, R A Bondarenko
Analysis of archival data revealed subsidence of situational anxiety accompanying work under psycho-emotional stress after administration of pharmacologically different psychotropic agents, such as stimulant mesocarb, nootropic and anxiolytic fenibut, tranquilizer fenazepam and alpha-adrenoblocker proroxan. Effectiveness of pharmacological anxiety control was dependent on individual sensitivity to these agents. Prescription of the medications with allowance for the factor reduced group-average levels of situational anxiety in 1...
2015: Aviakosmicheskaia i Ekologicheskaia Meditsina, Aerospace and Environmental Medicine
https://www.readbyqxmd.com/read/25869755/pretreatment-with-curcumin-attenuates-anxiety-while-strengthens-memory-performance-after-one-short-stress-experience-in-male-rats
#13
Saida Haider, Fizza Naqvi, Zehra Batool, Saiqa Tabassum, Sadia Sadir, Laraib Liaquat, Faizan Naqvi, Nudrat Anwer Zuberi, Hina Shakeel, Tahira Perveen
It is observed that memories are more strengthened in a stressful condition. Studies have also demonstrated an association between stressful events and the onset of depression and anxiety. Considering the nootropic, anxiolytic and antidepressant-like properties of curcumin in various experimental approaches, we appraised the beneficial effects of this herb on acute immobilization stress-induced behavioral and neurochemical alterations. Rats in test group were administrated with curcumin (200mg/kg/day), dissolved in neutral oil, for 1 week...
June 2015: Brain Research Bulletin
https://www.readbyqxmd.com/read/25513360/-emotional-disorders-in-children-with-attention-deficit-hyperactivity-disorder
#14
(no author information available yet)
The article presents an overview of scientific publications devoted to the study of epidemiology, etiology, clinical manifestations and basic approaches to the treatment of Attention Deficit Hyperactivity Disorder (ADHD) in children. An analysis of the results shows a high frequency of comorbidity between ADHD and emotional disorders (anxiety) that determines the severity of the main clinical symptoms and leads to severe social maladaptation. Inclusion of anxiolytics and nootropics in treatment of ADHD is required...
2014: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/25473664/-emotional-disorders-in-children-with-attention-deficit-hyperactivity-disorder
#15
REVIEW
L S Chutko, S Iu Surushkina, Iu L Bondarchuk
The article presents an overview of scientific publications devoted to the study of epidemiology, etiology, clinical manifestations and basic approaches to the treatment of Attention Deficit Hyperactivity Disorder (ADHD) in children. An analysis of the results shows a high frequency of comorbidity between ADHD and emotional disorders (anxiety) that determines the severity of the main clinical symptoms and leads to severe social maladaptation. Inclusion of anxiolytics and nootropics in treatment of ADHD is required...
2014: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/25176261/-a-comparison-of-the-anxiolytic-effect-and-tolerability-of-selank-and-phenazepam-in-the-treatment-of-anxiety-disorders
#16
COMPARATIVE STUDY
V E Medvedev, O N Tereshchenko, A Iu Israelian, I K Chobanu, N V Kost, O Iu Sokolov, N F Miasoedov
Objective. To study the efficacy and tolerability of the new anxyolytic peptide selank in comparison with phenazepam. Material and methods. A comparative study of the anxiolytic effect and tolerability of selank and phenazepam was carried out in 60 patients with phobic-anxiety- and somatoform disorders (F40.2-9, F41.1-9, F45.0-1 by ICD-10) were examined. Results Pronounced anxiolytic and mild nootropic effects of selank were demonstrated. The anxiolytic effect lasted for a week after last receiving the peptide...
2014: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/25099639/aniracetam-does-not-alter-cognitive-and-affective-behavior-in-adult-c57bl-6j-mice
#17
Thomas W Elston, Ashvini Pandian, Gregory D Smith, Andrew J Holley, Nanjing Gao, Joaquin N Lugo
There is a growing community of individuals who self-administer the nootropic aniracetam for its purported cognitive enhancing effects. Aniracetam is believed to be therapeutically useful for enhancing cognition, alleviating anxiety, and treating various neurodegenerative conditions. Physiologically, aniracetam enhances both glutamatergic neurotransmission and long-term potentiation. Previous studies of aniracetam have demonstrated the cognition-restoring effects of acute administration in different models of disease...
2014: PloS One
https://www.readbyqxmd.com/read/25050302/neuropharmacological-effects-of-standardized-aqueous-stem-bark-extract-of-parkia-biglobossa-in-wistar-rats
#18
Tijani Adeniyi Yahaya, Samuel Ehiabhi Okhale, Salawu Oluwakanyinsola Adeola
OBJECTIVE: Parkia biglobossa stem bark decoction is a popular medicinal plant preparation used as calming agent for tensed patients in traditional medicine. The aim of this study was to evaluate the effects of aqueous stem bark extract of Parkia biglobossa (AEPB) and its active fraction AEPBF3 on anxiety, spontaneous alternation behavior, and locomotor activity. The open field apparatus was used to evaluate effects of AEPB and AEPBF3 on locomotion. The APBE and the active fraction AEPBF3 were standardized using reverse phase high performance liquid chromatography to establish finger print to ascertain identity and stability of the extracts over time...
January 2014: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/24713149/cotinine-reduces-depressive-like-behavior-working-memory-deficits-and-synaptic-loss-associated-with-chronic-stress-in-mice
#19
J Alex Grizzell, Alexandre Iarkov, Rosalee Holmes, Takahashi Mori, Valentina Echeverria
Chronic stress underlies and/or exacerbates many psychiatric conditions and often results in memory impairment as well as depressive symptoms. Such afflicted individuals use tobacco more than the general population and this has been suggested as a form of self-medication. Cotinine, the predominant metabolite of nicotine, may underlie such behavior as it has been shown to ameliorate anxiety and memory loss in animal models. In this study, we sought to investigate the effects of cotinine on working memory and depressive-like behavior in mice subjected to prolonged restraint...
July 15, 2014: Behavioural Brain Research
https://www.readbyqxmd.com/read/24432561/-the-influence-of-piracetam-on-behavior-and-brain-receptors-in-c57bl-6-and-balb-c-mice-nootropic-and-anxiolytic-effects
#20
G I Kovalev, E A Kondrakhin, R M Salimov, G G Neznamov
The influence of acute and long-term piracetam administration on the dynamics of rapid (non-specific, anxiolytic) and slow (specific, nootropic) behavioral drug effects, as well as on their interrelation with NMDA- and BDZ-receptors was studied in inbred mice strains differing in cognitive and emotional status--C57BL/6 and BALB/c. The BALB/c strain contained 17% less [3H]-flunitrazepam binding sites in frontal cortex and 22% less [3H]-MK801 binding sites in hippocampus as compared to those in C57BL/6 mice. Based on these data, BALB/c strain was used as a model of psychopathology, combining increased anxiety and cognitive deficit...
2013: Eksperimental'naia i Klinicheskaia Farmakologiia
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