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https://www.readbyqxmd.com/read/29454042/when-do-you-start-and-when-do-you-stop-screening-for-colon-cancer-in-inflammatory-bowel-disease
#1
Millie D Long, Bruce E Sands
No abstract text is available yet for this article.
February 14, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29451783/sufex-click-chemistry-enabled-late-stage-drug-functionalization
#2
Zilei Liu, Jie Li, Suhua Li, Gencheng Li, K Barry Sharpless, Peng Wu
Sulfur(VI) Fluoride Exchange (SuFEx) is a new family of click chemistry transformations which relies on readily available materials to produce compounds bearing the S VI -F motif. The potential of SuFEx in drug discovery has just started to be explored. We report the first method of SuFEx chemistry for the conversion of phenolic compounds to their respective arylfluorosulfate derivatives in situ in 96-well plates. This method is compatible with automated synthesis and screening to quickly assess the biological activities of the in situ generated, crude products...
February 16, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29448493/visually-detecting-the-variation-of-mir-301a-expression-using-gold-nanoparticle-beacon
#3
Ying Zhang, Kai Li, Dandan Li, Changfeng Li, Bin Zhang
It is well known that microRNA-301a plays an important role in many diseases, as well as is overexpressed in human colon cancer and affects the process of tumorigenesis. Determination of the miR-301a expression provides insight into the mechanism of tumor progression. In this study, we designed a special hairpin deoxyribonucleic acid (DNA) for miR-301a to functionalize gold nanoparticles, which served as a beacon for detecting miR-301a expression. A-quenching efficiency up to 90% was achieved. The beacon we designed in this study can monitor the precise variation of miR-301a expression in vivo...
February 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29444662/a-systematic-approach-to-rna-associated-motif-discovery
#4
Tian Gao, Jiang Shu, Juan Cui
BACKGROUND: Sequencing-based large screening of RNA-protein and RNA-RNA interactions has enabled the mechanistic study of post-transcriptional RNA processing and sorting, including exosome-mediated RNA secretion. The downstream analysis of RNA binding sites has encouraged the investigation of novel sequence motifs, which resulted in exceptional new challenges for identifying motifs from very short sequences (e.g., small non-coding RNAs or truncated messenger RNAs), where conventional methods tend to be ineffective...
February 14, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29444450/high-throughput-screening-identifies-small-molecules-that-bind-to-the-ras-sos-ras-complex-and-perturb-ras-signaling
#5
Michael C Burns, Jennifer E Howes, Qi Sun, Andrew J Little, DeMarco V Camper, Jason R Abbott, Jason Phan, Taekyu Lee, Alex G Waterson, Olivia W Rossanese, Stephen W Fesik
K-RAS is mutated in approximately 30% of human cancers, resulting in increased RAS signaling and tumor growth. Thus, RAS is a highly validated therapeutic target, especially in tumors of the pancreas, lung and colon. Although directly targeting RAS has proven to be challenging, it may be possible to target other proteins involved in RAS signaling, such as the guanine nucleotide exchange factor Son of Sevenless (SOS). We have previously reported on the discovery of small molecules that bind to SOS1, activate SOS-mediated nucleotide exchange on RAS, and paradoxically inhibit ERK phosphorylation (Burns et al...
February 11, 2018: Analytical Biochemistry
https://www.readbyqxmd.com/read/29438375/telomere-length-and-genetics-are-independent-colorectal-tumour-risk-factors-in-an-evaluation-of-biomarkers-in-normal-bowel
#6
Ceres Fernandez-Rozadilla, Christiana Kartsonaki, Connor Woolley, Michael McClellan, Deb Whittington, Gareth Horgan, Simon Leedham, Skirmantas Kriaucionis, James East, Ian Tomlinson
BACKGROUND: Colorectal cancer (CRC) screening might be improved by using a measure of prior risk to modulate screening intensity or the faecal immunochemical test threshold. Intermediate molecular biomarkers could aid risk prediction by capturing both known and unknown risk factors. METHODS: We sampled normal bowel mucosa from the proximal colon, distal colon and rectum of 317 individuals undergoing colonoscopy. We defined cases as having a personal history of colorectal polyp(s)/cancer, and controls as having no history of colorectal neoplasia...
February 13, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29434857/correlation-between-tap-detection-and-common-digestive-tract-precancerous-lesions
#7
Changqing Sun, Fang Deng, Lingjun Meng, Guohua Chen
The aim of the present study was to investigate the clinical significance of abnormal sugar-chain glycoprotein tumor abnormal protein (TAP) in the screening of common digestive tract pre-cancer colon adenocarcinoma lesions. A total of 50 colitis patients, 50 colon polyp patients and 50 colon adenocarcinoma patients admitted to our hospital from March, 2012 to May, 2014 were included. Fresh blood from patient's fingertips was collected and condensation staining was used to detect TAP expression. Positive expressions of TAP in patients in the colitis, colon polyp and colon adenocarcinoma groups prior to treatment were 6,76 and 92%, respectively...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29434658/healthy-living-and-cancer-evidence-from-uk-biobank
#8
Peter C Elwood, Alex Whitmarsh, John Gallacher, Anthony Bayer, Richard Adams, Luke Heslop, Janet Pickering, Gareth Morgan, Julieta Galante, Sunil Dolwani, Marcus Longley, Zoe E Roberts
Context: UK Biobank is a prospective study of half a million subjects, almost all aged 40-69 years, identified in 22 centres across the UK during 2006-2010. Objective: A healthy lifestyle has been described as 'better than any pill, and no side effects [5]. We therefore examined the relationships between healthy behaviours: low alcohol intake, non-smoking, healthy BMI, physical activity and a healthy diet, and the risk of all cancers, colon, breast and prostate cancers in a large dataset...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29430186/identification-of-genomic-expression-differences-between-right-sided-and-left-sided-colon-cancer-based-on-bioinformatics-analysis
#9
Qiliang Peng, Kaisu Lin, Tao Chang, Li Zou, Pengfei Xing, Yuntian Shen, Yaqun Zhu
Introduction: More and more findings have demonstrated that right-sided colon cancers (RCC) and left-sided colon cancers (LCC) are distinct clinical and biological entities and suggest that they should be treated as different diseases. However, the reasons why RCC and LCC harbor different clinical and biological features remain unclear. Materials and methods: To identify the genomic expression differences between RCC and LCC and uncover the mechanisms underlying these differences, we chose the gene expression profiles of GSE14333 from the Gene Expression Omnibus (GEO) database as an object of study...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29427228/the-influence-of-screening-on-outcomes-of-clinically-locally-advanced-rectal-cancer
#10
A M Dinaux, L G J Leijssen, L G Bordeianou, H Kunitake, D L Berger
BACKGROUND: Screening for colorectal cancer has resulted in declining incidence rates of both colon and rectal cancer and it may influence stage at presentation and improve survival. The aim of this study was to assess the impact of screening on patients diagnosed with locally advanced rectal cancer. METHODS: A retrospective analysis of a consecutive series of patients who underwent neoadjuvant therapy and had an R0-resection for clinical AJCC stage II or stage III disease...
February 9, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29427084/rosmarinic-acid-mitigates-mitochondrial-dysfunction-and-spinal-glial-activation-in-oxaliplatin-induced-peripheral-neuropathy
#11
Aparna Areti, Prashanth Komirishetty, Anil Kumar Kalvala, Karthika Nellaiappan, Ashutosh Kumar
Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting complication which develops as a consequence of treatment with chemotherapeutic agents like oxaliplatin and is a mainstay of therapy for colorectal cancer. Ever since CIPN was identified, understanding its exact pathomechanisms remains a clinical challenge. The role of mitochondrial dysfunction and glial cell activation has surfaced in the etiology of CIPN. Rosmarinic acid (RA), a known mitoprotectant exerts neuroprotection against the oxidative stress and neuroinflammation in various disease conditions...
February 9, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29423100/proteomic-profiling-of-antibody-inducing-immunogens-in-tumor-tissue-identifies-psma1-lap3-anxa3-and-maspin-as-colon-cancer-markers
#12
Qian Yang, Michael H Roehrl, Julia Y Wang
We hypothesized that cancer tissue immunogens - antigens capable of inducing specific antibody production in patients - are promising targets for development of precision diagnostics and humoral immunotherapies. We developed an innovative immuno-proteomic strategy and identified new immunogenic markers of colon cancer. Proteins from cancers and matched normal tissues were separated by 2D gel electrophoresis and blotted with serum antibodies from the same patients. Antibody-reactive proteins were sequenced by mass spectrometry and validated by Western blotting and immunohistochemistry...
January 9, 2018: Oncotarget
https://www.readbyqxmd.com/read/29422016/malignancy-during-pregnancy-in-japan-an-exceptional-opportunity-for-early-diagnosis
#13
Masayuki Sekine, Yoshiyuki Kobayashi, Tsutomu Tabata, Tamotsu Sudo, Ryuichiro Nishimura, Koji Matsuo, Brendan H Grubbs, Takayuki Enomoto, Tomoaki Ikeda
BACKGROUND: Malignancy during pregnancy has become a significant cause of maternal death in developed countries, likely due to both an older pregnant population, and increases of cervical cancer in younger women. Our aim is to investigate the clinical aspects of malignancy during pregnancy in Japan and to use this information to identify opportunities for earlier detection and treatment. METHODS: We provided a questionnaire to 1508 secondary or tertiary care hospitals in Japan...
February 8, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29421953/using-community-engagement-and-navigators-to-increase-colon-cancer-screening-and-patient-outcomes
#14
Paul G Devereux, John Gray, Susan Robinson, Janie Galvin, Jesse Gutierrez
A theory-driven tailored intervention developed in partnership with the community used evidence-based practices to (a) increase knowledge about colon cancer and screening and (b) assist patients in completing screenings. During the 16 months of delivery screening, patient navigators integrated into gastroenterology clinics met all goals, which included (a) enrolling an ethnically diverse group of participants ( N = 415) through inreach (clinic-referred patients who did not schedule appointments) and community outreach, (b) facilitating screening completions for 217 of the 358 (61%) patients identified as needing screening, and (c) obtaining satisfaction ratings from 89% of participants...
February 1, 2018: Health Promotion Practice
https://www.readbyqxmd.com/read/29417332/left-sided-colectomy-one-of-the-important-risk-factors-of-metachronous-colorectal-adenoma-after-colectomy-for-colon-cancer
#15
Gee Young Yun, Hee Seok Moon, In Sun Kwon, Ju Seok Kim, Sun Hyung Kang, Eaum Seok Lee, Seok Hyun Kim, Jae Kyu Sung, Byung Seok Lee, Hyun Yong Jeong
BACKGROUND: Patients with a history of colonic resection for cancer have an increased risk for the development of metachronous malignant lesions. However, there is a lack of data on the detection rates of premalignant lesions during colonoscopy surveillance in these patients, and the few existing studies have shown conflicting results. AIMS: To identify the risk factor of metachronous premalignant lesions after colon cancer surgery. METHODS: We retrospectively screened consecutive patients who had undergone colonic surgery to treat colon cancer at the Chungnam National University Hospital between September 2009 and April 2014...
February 8, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29411294/timed-colonoscopy-withdrawal-a-mandatory-quality-measure-in-the-era-of-national-screening
#16
Vikrant Parihar, Claire O'Leary, Paud O'Reagan
BACKGROUND: A minimum recommended withdrawal time for screening colonoscopy is recommended for by both the US Multi-Society Task Force on Colorectal Cancer and European Society of Gastrointestinal Endoscopy. AIM: To characterize the relationship between endoscopists withdrawal time at colonoscopy and polyp detection in a symptomatic cohort of patients as compared to previously untimed withdrawal. METHODS: Three experienced medical endoscopists prospectively performed 1079 colonoscopies during a 24-month period in an Irish hospital...
February 6, 2018: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29408304/participatory-research-to-advance-colon-cancer-prevention-prompt-study-protocol-for-a-pragmatic-trial
#17
Jamie H Thompson, Melinda Davis, Michael C Leo, Jennifer L Schneider, David H Smith, Amanda F Petrik, Melissa Castillo, Brittany Younger, Gloria D Coronado
BACKGROUND: Colon cancer is the second leading cause of cancer deaths in the United States. The Participatory Research to Advance Colon Cancer Prevention (PROMPT) study is a collaboration between two research institutions and a federally qualified health center (FQHC). The study seeks to raise colon cancer screening rates using a direct-mail fecal immunochemical testing (FIT) and reminder program in an FQHC serving a predominantly Latino population in California. METHODS: PROMPT is a pragmatic trial enrolling 16 clinics...
February 2, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29404921/update-on-bowel-preparation-for-colonoscopy
#18
REVIEW
Cristina C Rutherford, Audrey H Calderwood
PURPOSE OF REVIEW: Colonoscopy is the gold standard for visualization and diagnosis of conditions involving the colon and terminal ileum. It also facilitates screening and prevention of colorectal cancer, which is the second leading cause of cancer death in the USA. Adequate cleansing is essential for thorough visualization of the colon with successful detection of colon polyps. RECENT FINDINGS: While the original large-volume polyethylene glycol preparations are still commonly used, several lower volume regimens are widely available and selected based on provider and patient preferences...
February 5, 2018: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/29402903/loss-of-function-uorf-mutations-in-human-malignancies
#19
Julia Schulz, Nancy Mah, Martin Neuenschwander, Tabea Kischka, Richard Ratei, Peter M Schlag, Esmeralda Castaños-Vélez, Iduna Fichtner, Per-Ulf Tunn, Carsten Denkert, Oliver Klaas, Wolfgang E Berdel, Jens P von Kries, Wojciech Makalowski, Miguel A Andrade-Navarro, Achim Leutz, Klaus Wethmar
Ribosome profiling revealed widespread translational activity at upstream open reading frames (uORFs) and validated uORF-mediated translational control as a commonly repressive mechanism of gene expression. Translational activation of proto-oncogenes through loss-of-uORF mutations has been demonstrated, yet a systematic search for cancer-associated genetic alterations in uORFs is lacking. Here, we applied a PCR-based, multiplex identifier-tagged deep sequencing approach to screen 404 uORF translation initiation sites of 83 human tyrosine kinases and 49 other proto-oncogenes in 308 human malignancies...
February 5, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29402572/motivational-interviewing-and-screening-colonoscopy-in-high-risk-individuals-a-randomized-controlled-trial
#20
Hamideh Salimzadeh, Roghaye Khabiri, Maryam Khazaee-Pool, Somayeh Salimzadeh, Alireza Delavari
OBJECTIVE: To measure the impact of motivational interviewing (MI) on cancer knowledge and screening practice among first degree relatives (FDRs) of patients with colon cancer. METHODS: This randomized controlled trial targeted patients with colon cancer first to recruit their possible FDRs. Digit randomization of the eligible index patients into intervention or control groups resulted in allocating their belonging FDRs to the same study arm. FDRs (n = 120) in intervention arm received MI counseling on phone by a trained oncology nurse and FDRs (n = 120) in control group received standard generic information by a physician on phone...
February 2, 2018: Patient Education and Counseling
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