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https://www.readbyqxmd.com/read/29675660/rates-of-prevalent-colorectal-cancer-occurrence-in-persons-75-years-of-age-and-older-a-population-based-national-study
#1
Vijit Chouhan, Emad Mansoor, Sravanthi Parasa, Gregory S Cooper
BACKGROUND/AIMS: There is a lack of studies describing the epidemiology of colorectal cancer (CRC) in patients aged 75 years and older (elderly). Current guidelines recommend against routine screening colonoscopies in this population. We sought to describe the epidemiology of CRC in the elderly, utilizing a large, population-based database as this may impact screening guidelines in this population. METHODS: Utilizing a commercial database (Explorys Inc, Cleveland, OH), we identified a cohort of patients with a first-ever diagnosis of CRC between 2012 and 2017 based on the Systematized Nomenclature of Medicine-Clinical Terms...
April 19, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29671617/oxazole-and-thiazole-analogs-of-sulindac-for-cancer-prevention
#2
Bini Mathew, Judith V Hobrath, Michele C Connelly, R Kiplin Guy, Robert C Reynolds
AIM: Experimental and epidemiological studies and clinical trials suggest that nonsteroidal anti-inflammatory drugs possess antitumor potential. Sulindac, a widely used nonsteroidal anti-inflammatory drug, can prevent adenomatous colorectal polyps and colon cancer, especially in patients with familial adenomatous polyposis. Sulindac sulfide amide (SSA) is an amide-linked sulindac sulfide analog that showed in vivo antitumor activity in a human colon tumor xenograft model. Results/methodology: A new analog series with heterocyclic rings such as oxazole or thiazole at the C-2 position of sulindac was prepared and screened against prostate, colon and breast cancer cell lines to probe the effect of these novel substitutions on the activity of sulindac analogs...
April 19, 2018: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/29667008/eco-friendly-synthesis-in-vitro-anti-proliferative-evaluation-and-3d-qsar-analysis-of-a-novel-series-of-monocationic-2-aryl-heteroaryl-substituted-6-2-imidazolinyl-benzothiazole-mesylates
#3
Livio Racané, Lucija Ptiček, Mirela Sedić, Petra Grbčić, Sandra Kraljević Pavelić, Branimir Bertoša, Irena Sović, Grace Karminski-Zamola
Herein, we describe the synthesis of twenty-one novel water-soluble monocationic 2-aryl/heteroaryl-substituted 6-(2-imidazolinyl)benzothiazole mesylates 3a-3u and present the results of their anti-proliferative assays. Efficient syntheses were achieved by three complementary simple two-step synthetic protocols based on the condensation reaction of aryl/heteroaryl carbaldehydes or carboxylic acid. We developed an eco-friendly synthetic protocol using glycerol as green solvent, particularly appropriate for the condensation of thermally and acid-sensitive heterocycles such as furan, benzofuran, pyrrole, and indole...
April 17, 2018: Molecular Diversity
https://www.readbyqxmd.com/read/29666615/significance-of-streptococcus-gallolyticus-subsp-gallolyticus-association-with-colorectal-cancer
#4
REVIEW
Ewa Pasquereau-Kotula, Mariana Martins, Laetitia Aymeric, Shaynoor Dramsi
Streptococcus gallolyticus subsp. gallolyticus Sgg (formerly known as S. bovis type I) is the main causative agent of septicemia and infective endocarditis (IE) in elderly and immunocompromised persons. It belongs to the few opportunistic bacteria, which have been strongly associated to colorectal cancer (CRC). A literature survey covering a period of 40 years (1970-2010) revealed that 65% of patients diagnosed with an invasive Sgg infection had a concomitant colorectal neoplasia. Sgg is associated mainly with early adenomas and may thus constitute an early marker for CRC screening...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29665437/multiplex-serology-of-helicobacter-pylori-antigens-in-detection-of-current-infection-and-atrophic-gastritis-a-simple-and-cost-efficient-method
#5
Ebrahim Shafaie, Samaneh Saberi, Maryam Esmaeili, Zeynab Karimi, Saeed Najafi, Mohammad Tashakoripoor, Afshin Abdirad, Mahmoud Eshagh Hosseini, Mohammad Ali Mohagheghi, Vahid Khalaj, Marjan Mohammadi
INTRODUCTION: Helicobacter pylori express a large array of antigens, each of which is duly responsible for successful colonization and pathogenesis. Here, we have studied host serum antibody responses to four of its immunodominant antigens in association with the infection status and the resulting clinical outcomes. METHODS: For this purpose, four individual H. pylori proteins (UreB, CagA, Tip-α and HP0175) were produced in recombinant forms. Serum antibody responses of 246 (75 GC and 171 NUD) patients, against the above antigens, were evaluated by multiplex immunoblotting...
April 14, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29664311/feasibility-of-colon-cancer-screening-by-fecal-immunochemical-test-in-iran
#6
Hamideh Salimzadeh, Faraz Bishehsari, Catherine Sauvaget, Mohammad Amani, Gholamreza Hamzehloo, Ali Nikfarjam, Shahin Merat, Alireza Delavari, Reza Malekzadeh
BACKGROUND: Colorectal cancer (CRC) is the third most common cancer in Iran, where there is no mass screening for the disease yet. We aimed to measure the feasibility of a pilot CRC screening program based on fecal immunochemical test (FIT) in Iranian population and the implications for scaling-up at the national level. METHODS: A single quantitative FIT was offered by health navigators to individuals aged between 45 and 75 years in primary health centers in rural and urban areas in Tehran...
December 1, 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/29661279/sources-of-distress-among-patients-undergoing-surgery-for-colorectal-cancer-a-qualitative-study
#7
Jonathan S Abelson, Alanna Chait, Megan J Shen, Mary Charlson, Anna Dickerman, Heather L Yeo
BACKGROUND: Distress is common among cancer and surgical patients and can lead to worse outcomes if untreated. The objective of this study was to explore sources of distress among colorectal cancer patients undergoing surgery. MATERIALS AND METHODS: This was a qualitative study using in-depth, semistructured, one-on-one interviews in an academic setting. Patients were recruited if they had a pathologically confirmed diagnosis of colon or rectal cancer. Purposive sampling was used to recruit patients who were about to undergo (preoperative), or had recently undergone (postoperative), curative resection for colorectal cancer...
June 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29644509/applications-of-colon-capsule-endoscopy
#8
REVIEW
Shabana F Pasha
PURPOSE OF REVIEW: This is a review of colon capsule endoscopy (CCE) with a focus on its recent developments, technological improvements, and current and potential future indications. RECENT FINDINGS: Based on the current literature, CCE II demonstrates comparable polyp detection rates as optical colonoscopy and CT colonography, and improved cost-effectiveness. The main limitation to patient acceptance is the requirement of a rigorous bowel preparation. Preliminary studies show good correlation between CCE and optical colonoscopy for assessment of colonic disease activity in inflammatory bowel disease (IBD)...
April 12, 2018: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/29627691/selective-cytotoxic-and-genotoxic-activities-of-5-2-bromo-5-methoxybenzylidene-thiazolidine-2-4-dione-against-nci-h292-human-lung-carcinoma-cells
#9
Maria do D Rodrigues, Priscila B G S Santiago, Karla M R Marques, Valéria R A Pereira, Maria C A B de Castro, Jeanne C L L Cantalice, Teresinha G da Silva, Mônica L Adam, Silene C do Nascimento, Julianna F C de Albuquerque, Gardenia C G Militao
BACKGROUND: Thiazolidine-2,4-dione ring system is used as a pharmacophore to build various heterocyclic compounds aimed to interact with biological targets. In the present study, benzylidene-2,4-thiazolidinedione derivatives (compounds 2-5) were synthesized and screened against cancer cell lines and the genotoxicity and cytotoxicity of the most active compound (5) was investigated on normal and lung cancer cell line. METHODS: For in vitro cytotoxic screening, the MTT assay was used for HL60 and K562 (leukemia), MCF-7 (breast adenocarcinoma), HT29 (colon adenocarcinoma), HEp-2 (cervix carcinoma) and NCI-H292 (lung carcinoma) tumor cell lines and Alamar-blue assay was used for non-tumor cells (PBMC, human peripheral blood mononuclear cells) were used...
November 22, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29626277/evaluation-of-fecal-m2pk-as-a-diagnostic-marker-in-colorectal-cancer
#10
Hisham K Dabbous, Yosry Abd El-Rahman Mohamed, Runia F El-Folly, Mohamed D El-Talkawy, Hani E Seddik, Dina Johar, Mohammed A Sarhan
BACKGROUND: Invasive colonoscopy is the gold standard for patients at risk for colorectal cancer. However, the need for non-invasive and specific markers is required. OBJECTIVE: To evaluate the sensitivity of the glycolytic pyruvate kinase isoenzyme type M2 dimer (M2PK) as a diagnostic biomarker for colorectal cancer (CRC) and adenomatous colorectal polyps (CRP) screening. DESIGN: Case-control. PATIENTS: Twenty patients with CRC, 20 patients with CRP (lack criteria for colonic cancer by biopsy), and 20 normal subjects...
April 7, 2018: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29616330/colorectal-cancer-in-the-young
#11
REVIEW
Swati G Patel, Dennis J Ahnen
PURPOSE OF REVIEW: Colorectal cancer incidence has been rapidly rising in those under the age of 50 over the last 20 years. This paper will review the epidemiology, clinicopathologic, molecular features, proposed risk factors, and prevention/treatment approach for early onset CRC (EOCRC) patients. RECENT FINDINGS: EOCRC appears to have a different spectrum of clinical, pathologic, and molecular presentation compared to CRC diagnosed in older individuals. EOCRCs are disproportionately located in the distal colon; these patients tend to present with symptoms, and there is a longer interval between symptoms and diagnosis...
March 28, 2018: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/29615843/bioinformatic-analysis-of-prognostic-value-of-zw10-interacting-protein-in-lung-cancer
#12
Wen Yuan, Songping Xie, Meng Wang, Shan Pan, Xiaoxing Huang, Meng Xiong, Rui-Jing Xiao, Jie Xiong, Qiu-Ping Zhang, Liang Shao
Background: ZWINT is a crucial component of the mitotic checkpoint. However, its possible role in lung cancer is unclear. In this study, we determined its correlation with lung cancer. Methods: Real-time PCR and immunohistochemistry (IHC) were used to determine 40 collected clinical lung cancer samples. Chi-square test was used to examine possible correlations between ZWINT expression and clinicopathological factors. The prognostic significance of mRNA expression of ZWINT in lung cancer was evaluated using the Kaplan-Meier plotter...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29615487/comparison-of-prognostic-models-to-predict-the-occurrence-of-colorectal-cancer-in-asymptomatic-individuals-a-systematic-literature-review-and-external-validation-in-the-epic-and-uk-biobank-prospective-cohort-studies
#13
Todd Smith, David C Muller, Karel G M Moons, Amanda J Cross, Mattias Johansson, Pietro Ferrari, Guy Fagherazzi, Petra H M Peeters, Gianluca Severi, Anika Hüsing, Rudolf Kaaks, Anne Tjonneland, Anja Olsen, Kim Overvad, Catalina Bonet, Miguel Rodriguez-Barranco, Jose Maria Huerta, Aurelio Barricarte Gurrea, Kathryn E Bradbury, Antonia Trichopoulou, Christina Bamia, Philippos Orfanos, Domenico Palli, Valeria Pala, Paolo Vineis, Bas Bueno-de-Mesquita, Bodil Ohlsson, Sophia Harlid, Bethany Van Guelpen, Guri Skeie, Elisabete Weiderpass, Mazda Jenab, Neil Murphy, Elio Riboli, Marc J Gunter, Krasimira Jekova Aleksandrova, Ioanna Tzoulaki
OBJECTIVE: To systematically identify and validate published colorectal cancer risk prediction models that do not require invasive testing in two large population-based prospective cohorts. DESIGN: Models were identified through an update of a published systematic review and validated in the European Prospective Investigation into Cancer and Nutrition (EPIC) and the UK Biobank. The performance of the models to predict the occurrence of colorectal cancer within 5 or 10 years after study enrolment was assessed by discrimination (C-statistic) and calibration (plots of observed vs predicted probability)...
April 3, 2018: Gut
https://www.readbyqxmd.com/read/29610512/risk-of-interval-cancer-in-fecal-immunochemical-test-screening-significantly-higher-during-the-summer-months-results-from-the-national-cancer-screening-program-in-korea
#14
Jae Myung Cha, Mina Suh, Min Seob Kwak, Na Young Sung, Kui Son Choi, Boyoung Park, Jae Kwan Jun, Sang-Hyun Hwang, Do-Hoon Lee, Byung Chang Kim, You Kyoung Lee, Dong Soo Han
OBJECTIVES: This study aimed to evaluate the impact of seasonal variations in climate on the performance of the fecal immunochemical test (FIT) in screening for colorectal cancer in the National Cancer Screening Program in Korea. METHODS: Data were extracted from the National Cancer Screening Program databases for participants who underwent FIT between 2009 and 2010. We compared positivity rates, cancer detection rates, interval cancer rates, positive predictive value, sensitivity, and specificity for FIT during the spring, summer, fall, and winter seasons in Korea...
April 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29609829/is-the-virtual-colonoscopy-a-replacement-for-optical-colonoscopy
#15
REVIEW
Andrew Guinigundo
OBJECTIVE: To examine the viability of colon cancer screening with computed tomography colonography, also known as virtual colonoscopy. DATA SOURCES: Clinical guidelines, published medical research. CONCLUSION: Virtual colonoscopy, under the right circumstances, is an accurate viable screening tool for patients who may not otherwise desire to or are not able to participate in traditional colonoscopy. IMPLICATIONS FOR NURSING PRACTICE: Nurses should be aware that routine colon cancer screening is recommended starting at age 50...
March 30, 2018: Seminars in Oncology Nursing
https://www.readbyqxmd.com/read/29605057/first-nations-people-s-perspectives-on-barriers-and-supports-for-enhancing-hpv-vaccination-foundations-for-sustainable-community-driven-strategies
#16
R I Henderson, M Shea-Budgell, C Healy, A Letendre, L Bill, B Healy, R A Bednarczyk, K Mrklas, C Barnabe, J Guichon, N Bedingfield, S MacDonald, A Colquhoun, S Glaze, T Nash, C Bell, J Kellner, R Richardson, T Dixon, J Starlight, G Runner, G Nelson
OBJECTIVE: In Canada, Indigenous people have higher human papillomavirus (HPV) infection rates, lower screening rates for cervical cancer, and higher rates of invasive cancer, leading to worse cervical cancer-related outcomes than observed in non-Indigenous Canadian women. Lingering harms from European colonization drive these health inequities and create public health challenges. Policy guidance is needed to optimize HPV vaccination rates and, thereby, decrease the burden of HPV-related illness, including high-morbidity surgical procedures and chemo-radiotherapy...
April 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29593231/metabolomic-approach-for-a-rapid-identification-of-natural-products-with-cytotoxic-activity-against-human-colorectal-cancer-cells
#17
Vittoria Graziani, Monica Scognamiglio, Valentina Belli, Assunta Esposito, Brigida D'Abrosca, Angela Chambery, Rosita Russo, Marta Panella, Aniello Russo, Fortunato Ciardiello, Teresa Troiani, Nicoletta Potenza, Antonio Fiorentino
The discovery of bioactive compounds from natural sources entails an extremely lengthy process due to the timescale and complexity of traditional methodologies. In our study, we used a rapid NMR based metabolomic approach as tool to identify secondary metabolites with anti-proliferative activity against a panel of human colorectal cancer cell lines with different mutation profiles. For this purpose, fourteen Fabaceae species of Mediterranean vegetation were investigated using a double screening method:1 H NMR profiling enabled the identification of the main compounds present in the mixtures, whilst parallel biological assays allowed the selection of two plant extracts based on their strong anti-proliferative properties...
March 28, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29590746/utility-of-braf-ve1-immunostaining-as-a-screening-tool-for-colorectal-cancer-harboring-braf-v600e-mutation
#18
Jeong-Hwa Kwon, Byung-Kwan Jeong, Yong Sik Yoon, Chang Sik Yu, Jihun Kim
Background: BRAF mutation has been recognized as an important biomarker of colorectal cancer (CRC) for targeted therapy and prognosis prediction. However, sequencing of every CRC case is not cost-effective. Since an antibody specific for BRAF V600E mutant protein was introduced, we examined the utility of BRAF VE1 immunohistochemistry for evaluating BRAF mutations in CRC. Materials and Methods: Fifty-one BRAF-mutated and age, sex-matched 100 BRAF-wild type CRCs were selected at Asan Medical Center from 2005 to 2015...
March 29, 2018: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29589319/identification-of-novel-molecules-targeting-cancer-stem-cells
#19
Yannick D Benoit
Multiple studies focused on tumor heterogeneity and cellular hierarchies have demonstrated the role of cancer stem cells (CSC) in tumor initiation and recurrence. Colorectal cancer is one of the leading causes of cancer-related death and is hierarchically organized, with the majority of tumor cells descending from a small population of colon cancer stem cells (CCSCs). Such a rare self-renewing population is marked by the acquisition of distinct chromatin regulation and transcriptional programs. Fundamental molecular deviations between CCSCs and bulk tumor cells as well as normal tissues represent a unique therapeutic access to develop novel, selective anticancer therapies...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29589310/rt-qpcr-for-fecal-mature-microrna-quantification-and-validation
#20
Farid E Ahmed, Nancy C Ahmed, Mostafa M Gouda, Paul W Vos, Chris Bonnerup
By routinely and systematically being able to perform quantitative stem-loop reverse transcriptase (RT) followed by TaqMan® minor-groove binding (MGB) probe, real-time quantitative PCR analysis on exfoliated enriched colonocytes in stool, using human (Homo sapiens, hsa) micro(mi)RNAs to monitor changes of their expression at various stages of colorectal (CRC) progression, this method allows for the reliable and quantitative diagnostic screening of colon cancer (CC). Although the expression of some miRNA genes tested in tissue shows less variability in normal or cancerous patients than in stool, the noninvasive stool by itself is well suited for CC screening...
2018: Methods in Molecular Biology
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