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https://www.readbyqxmd.com/read/28231692/risk-and-characteristics-of-postcolonoscopy-interval-colorectal-cancer-after-a-positive-fecal-test-a-nationwide-population-based-study-in-korea
#1
Chang Kyun Lee, Kui Son Choi, Chang Soo Eun, Dong-Il Park, Dong Soo Han, Minjoo Yoon, Mina Suh, Jae Kwan Jun
Purpose: Fecal tests remain a mainstay of population-based colorectal cancer (CRC) screening programs worldwide. However, data on interval CRC (iCRC) arising after follow-up colonoscopy of a positive fecal test are scarce. We conducted a nationwide population-based study to reveal the risk and characteristics of iCRC in this setting. Materials and Methods: We searched the National Cancer Screening Program for CRC database in Korea (2005-2010). Incidence of iCRC within the program was estimated, then Cox proportional-hazards regression analysis was performed to determine the independent predictors of iCRC...
February 24, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28231524/discovery-of-novel-cdk8-inhibitors-using-multiple-crystal-structures-in-docking-based-virtual-screening
#2
Taijin Wang, Zhuang Yang, Yongguang Zhang, Wei Yan, Fang Wang, Linhong He, Yuanyuan Zhou, Lijuan Chen
The cyclin dependent kinase CDK8, along with Med12 and Med13, form the kinase module of the Mediator complex. CDK8 expression associates with the activation of β-catenin in colon and gastric cancers. Herein, we applied docking-based virtual screening (VS) using the multiple crystal structures to identify several potent CDK8 inhibitors. The appropriate use of multiple crystal structures obtained a better enrichment of CDK8 conformations to cope with the protein flexibility. Later on, the 2D similarity search was used to find the derivatives of the high inhibitory CDK8 inhibitors we discovered by VS...
February 9, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28229027/risk-analysis-of-colorectal-cancer-incidence-by-gene-expression-analysis
#3
Wei-Chuan Shangkuan, Hung-Che Lin, Yu-Tien Chang, Chen-En Jian, Hueng-Chuen Fan, Kang-Hua Chen, Ya-Fang Liu, Huan-Ming Hsu, Hsiu-Ling Chou, Chung-Tay Yao, Chi-Ming Chu, Sui-Lung Su, Chi-Wen Chang
BACKGROUND: Colorectal cancer (CRC) is one of the leading cancers worldwide. Several studies have performed microarray data analyses for cancer classification and prognostic analyses. Microarray assays also enable the identification of gene signatures for molecular characterization and treatment prediction. OBJECTIVE: Microarray gene expression data from the online Gene Expression Omnibus (GEO) database were used to to distinguish colorectal cancer from normal colon tissue samples...
2017: PeerJ
https://www.readbyqxmd.com/read/28228152/cardiac-metastasis-from-colon-cancer-effectively-treated-with-5-fluorouracil-leucovorin-and-oxaliplatin-modified-folfox6-plus-panitumumab-a-case-report
#4
Yoshiki Tsujii, Yoshito Hayashi, Akira Maekawa, Tetsuji Fujinaga, Kengo Nagai, Shunsuke Yoshii, Akihiko Sakatani, Satoshi Hiyama, Shinichiro Shinzaki, Hideki Iijima, Tetsuo Takehara
BACKGROUND: Cardiac metastasis from colorectal cancer is rare. There is little evidence supporting the effectiveness of chemotherapy, and standard therapy for metastatic cardiac tumors has not been established. CASE PRESENTATION: A 76-year-old woman presented with a right ventricle tumor that was detected incidentally on screening cardiac ultrasonography. The initial computed tomography (CT) scan showed the cardiac tumor, which was approximately 40 mm in size, and multiple pulmonary nodules...
February 23, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28224040/massilioclostridium-coli-gen-nov-sp-nov-a-new-member-of-the-clostridiaceae-family-isolated-from-the-left-colon-of-a-27-year-old-woman
#5
C I Lo, M Mailhe, D Ricaboni, V Vitton, A Benezech, C Michelle, N Armstrong, F Bittar, P-E Fournier, D Raoult, J-C Lagier
Massilioclostridium coli strain Marseille-P2976(T) (= CSUR P2976 = DSM 103344) is a new bacterial genus isolated from the left colon of a patient who underwent colonoscopy for colorectal cancer screening. Massilioclostridium coli is a Gram-negative bacillus, strict anaerobic, nonsporogenous and nonmotile organism. We describe here the strain Marseille-P2976(T) and provide its complete annotated genome sequence according to taxonogenomics concepts. Its genome is 2 985 330 bp long and contains 2562 predicted genes and 75 RNA genes...
March 2017: New Microbes and New Infections
https://www.readbyqxmd.com/read/28218467/divergent-roles-of-p120-catenin-isoforms-linked-to-altered-cell-viability-proliferation-and-invasiveness-in-carcinogen-induced-rat-skin-tumors
#6
Rong Wang, Ying-Shiuan Chen, Wan-Mohaiza Dashwood, Qingjie Li, Christiane V Löhr, Kay Fischer, Emily Ho, David E Williams, Roderick H Dashwood
The heterocyclic amine 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) targets multiple organs for tumorigenesis in the rat, including the colon and the skin. PhIP-induced skin tumors were subjected to mutation screening, which identified genetic changes in Hras (7/40, 17.5%) and Tp53 (2/40, 5%), but not in Ctnnb1, a commonly mutated gene in PhIP-induced colon tumors. Despite the absence of Ctnnb1 mutations, β-catenin was overexpressed in nuclear and plasma membrane fractions from PhIP-induced skin tumors, coinciding with loss of p120-catenin from the plasma membrane, and the appearance of multiple p120-catenin-associated bands in the nuclear extracts...
February 20, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28210082/multitarget-stool-dna-tests-increases-colorectal-cancer-screening-among-previously-noncompliant-medicare-patients
#7
Mark Prince, Lynn Lester, Rupal Chiniwala, Barry Berger
AIM: To determine the uptake of noninvasive multitarget stool DNA (mt-sDNA) in a cohort of colorectal cancer (CRC) screening non-compliant average-risk Medicare patients. METHODS: This cross sectional primary care office-based study examined mt-sDNA uptake in routine clinical practice among 393 colorectal cancer screening non-compliant Medicare patients ages 50-85 ordered by 77 physicians in a multispecialty group practice (USMD Physician Services, Dallas, TX) from October, 2014-September, 2015...
January 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28205108/water-assisted-colonoscopy
#8
REVIEW
Sergio Cadoni, Felix W Leung
The current review will attempt to describe the important lessons learned from published randomized controlled trials (RCT) comparing water immersion (WI) or water exchange (WE) techniques with gas insufflation colonoscopy. Air insufflation (AI) to distend the colon to permit visualization and passage through the lumen was developed for diagnostic colonoscopy. When screening colonoscopy was adopted, the same AI method was used. Interval cancers, diagnosed within 3 to 5 years after an index screening colonoscopy, appeared to be linked to low adenoma detection rate (ADR)...
February 15, 2017: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/28199989/presence-of-cancer-associated-mutations-in-exhaled-breath-condensates-of-healthy-individuals-by-next-generation-sequencing
#9
Omar Youssef, Aija Knuuttila, Päivi Piirilä, Tom Böhling, Virinder Sarhadi, Sakari Knuutila
Exhaled breath condensate (EBC) is a non-invasive source that can be used for studying different genetic alterations occurring in lung tissue. However, the low yield of DNA available from EBC has hampered the more detailed mutation analysis by conventional methods. We applied the more sensitive amplicon-based next generation sequencing (NGS) to identify cancer related mutations in DNA isolated from EBC. In order to apply any method for the purpose of mutation screening in cancer patients, it is important to clarify the incidence of these mutations in healthy individuals...
February 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28195508/incidence-of-interval-cancers-in-faecal-immunochemical-test-colorectal-screening-programmes-in-italy
#10
Paolo Giorgi Rossi, Elisa Carretta, Lucia Mangone, Susanna Baracco, Diego Serraino, Manuel Zorzi
Objective In Italy, colorectal screening programmes using the faecal immunochemical test from ages 50 to 69 every two years have been in place since 2005. We aimed to measure the incidence of interval cancers in the two years after a negative faecal immunochemical test, and compare this with the pre-screening incidence of colorectal cancer. Methods Using data on colorectal cancers diagnosed in Italy from 2000 to 2008 collected by cancer registries in areas with active screening programmes, we identified cases that occurred within 24 months of negative screening tests...
January 1, 2017: Journal of Medical Screening
https://www.readbyqxmd.com/read/28194568/t1-colon-cancer-in-the-era-of-screening-risk-factors-and-treatment
#11
F Bianco, S De Franciscis, A Belli, A Falato, R Fusco, D F Altomare, A Amato, C R Asteria, A Avallone, G A Binda, L Boccia, P Buzzo, M Carvello, C Coco, P Delrio, P De Nardi, M Di Lena, A Failla, F La Torre, M La Torre, M Lemma, P Luffarelli, G Manca, I Maretto, F Marino, A Muratore, A Pascariello, S Pucciarelli, D Rega, V Ripetti, G Rizzo, A Serventi, A Spinelli, F Tatangelo, E D L Urso, G M Romano
BACKGROUND: The aim of this study was to identify risk factors for lymph node positivity in T1 colon cancer and to carry out a surgical quality assurance audit. METHODS: The sample consisted of consecutive patients treated for early-stage colon lesions in 15 colorectal referral centres between 2011 and 2014. The study investigated 38 factors grouped into four categories: demographic information, preoperative data, indications for surgery and post-operative data...
February 13, 2017: Techniques in Coloproctology
https://www.readbyqxmd.com/read/28193578/a-food-based-approach-that-targets-interleukin-6-a-key-regulator-of-chronic-intestinal-inflammation-and-colon-carcinogenesis
#12
Abigail Sido, Sridhar Radhakrishnan, Sung Woo Kim, Elisabeth Eriksson, Frank Shen, Qunhua Li, Vadiraja Bhat, Lavanya Reddivari, Jairam K P Vanamala
Studies have shown a causal link between high-calorie diet (HCD) and colon cancer. However, molecular mechanisms are not fully elucidated. To understand etiology of HCD-induced colon carcinogenesis, we screened 10 pathways linked to elevated colonic cell proliferation and chronic inflammation in an HCD-consuming human-relevant pig model. We observed elevated colonic mucosal interleukin-6 (IL-6) expression in HCD-consuming pigs compared to standard diet controls (SD, P=.04), and IL-6 strongly correlated with Ki-67 proliferative index and zone, early biomarkers of colon cancer risk (r=0...
January 28, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28186354/feasibility-of-cyfra-21-1-as-a-serum-biomarker-for-the-detection-of-colorectal-adenoma-and-advanced-colorectal-adenoma-in-people-over-the-age-of-45
#13
Do Hyoung Lim, Jai Hyuen Lee, Jong Wan Kim
BACKGROUND: Colon adenoma (CA) is a premalignant lesion of colorectal cancer, and its early removal is closely associated with more prolonged survival in the general population. In this study, we aimed to evaluate the relationship between diverse biologic markers and a newly diagnosed CA and to predict the clinical possibility of cytokeratin-19 soluble in serum fragment (CYFRA 21-1) as a screening tool in asymptomatic adults aged over 45 years. METHODS: Four hundred and seventy-nine patients with a histologically confirmed CA or benign colon polyp (BCP), 76 patients with only benign colorectal diseases and 223 negative controls with no CA or BCP detected on colonofibroscopy were investigated...
February 10, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28184026/identification-of-tmem208-and-pqlc2-as-reference-genes-for-normalizing-mrna-expression-in-colorectal-cancer-treated-with-aspirin
#14
Yuanyuan Zhu, Chao Yang, Mingjiao Weng, Yan Zhang, Chunhui Yang, Yinji Jin, Weiwei Yang, Yan He, Yiqi Wu, Yuhua Zhang, Guangyu Wang, Riju James RajkumarEzakiel Redpath, Lei Zhang, Xiaoming Jin, Ying Liu, Yuchun Sun, Ning Ning, Yu Qiao, Fengmin Zhang, Zhiwei Li, Tianzhen Wang, Yanqiao Zhang, Xiaobo Li
Numerous evidences indicate that aspirin usage causes a significant reduction in colorectal cancer. However, the molecular mechanisms about aspirin preventing colon cancer are largely unknown. Quantitative reverse transcription polymerase chain reaction (qRT-PCR) is a most frequently used method to identify the target molecules regulated by certain compound. However, this method needs stable internal reference genes to analyze the expression change of the targets. In this study, the transcriptional stabilities of several traditional reference genes were evaluated in colon cancer cells treated with aspirin, and also, the suitable internal reference genes were screened by using a microarray and were further identified by using the geNorm and NormFinder softwares, and then were validated in more cell lines and xenografts...
February 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28182647/performance-analysis-of-a-machine-learning-flagging-system-used-to-identify-a-group-of-individuals-at-a-high-risk-for-colorectal-cancer
#15
Yaron Kinar, Pinchas Akiva, Eran Choman, Revital Kariv, Varda Shalev, Bernard Levin, Steven A Narod, Ran Goshen
Individuals with colorectal cancer (CRC) have a tendency to intestinal bleeding which may result in mild to severe iron deficiency anemia, but for many colon cancer patients hematological abnormalities are subtle. The fecal occult blood test (FOBT) is used as a pre-screening test whereby those with a positive FOBT are referred to colonscopy. We sought to determine if information contained in the complete blood count (CBC) report coud be processed automatically and used to predict the presence of occult colorectal cancer (CRC) in the setting of a large health services plan...
2017: PloS One
https://www.readbyqxmd.com/read/28182555/comparative-validation-of-polyp-detection-methods-in-video-colonoscopy-results-from-the-miccai-2015-endoscopic-vision-challenge
#16
Jorge Bernal, Nima Tajbakhsh, F Javier Sanchez, Bogdan J Matuszewski, Hao Chen, Lequan Yu, Quentin Angermann, Olivier Romain, Bjorn Rustad, Ilangko Balasingham, Konstantin Pogorelov, Sungbin Choi, Quentin Debard, L Maier-Hein, Stefanie Speidel, Danail Stoyanov, Patrick Brandao, Henry Cordova, Cristina Sanchez-Montes, Suryakanth R Gurudu, Gloria Fernandez-Esparrach, Xavier Dray, Jianming Liang, Aymeric Histace
Colonoscopy is the gold standard for colon cancer screening though still some polyps are missed, thus preventing early disease detection and treatment. Several computational systems have been proposed to assist polyp detection during colonoscopy but so far without consistent evaluation. The lack of publicly available annotated databases has made it difficult to compare methods and to assess if they achieve performance levels acceptable for clinical use. The Automatic Polyp Detection subchallenge, conducted as part of the Endoscopic Vision Challenge (http://endovis...
February 2, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28179313/comparative-study-of-mutations-in-single-nucleotide-polymorphism-loci-of-kras-and-braf-genes-in-patients-who-underwent-screening-colonoscopy-with-and-without-premalignant-intestinal-polyps
#17
Michail Galanopoulos, Ioannis S Papanikolaou, Eleni Zografos, Nikos Viazis, George Papatheodoridis, Dimitrios Karamanolis, Evangelos Marinos, Gerassimos J Mantzaris, Maria Gazouli
AIM: Our aim was to perform a comparison study of the mutation rate of V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS), and v-Raf murine sarcoma viral oncogene homolog-B (BRAF) genes between blood-based cell-free DNA (cfDNA), and tissue sample biopsies in individuals undergoing screening colonoscopy. MATERIALS AND METHODS: All specimens were collected from January 2015 to January 2016. A total of 92 blood samples and colonic biopsy specimens were collected from healthy individuals with no polyps undergoing screening colonoscopy (group A, n=35), patients with colorectal cancer (group B, n=27), and patients with neoplastic intestinal polyps (group C, n=30)...
2017: Anticancer Research
https://www.readbyqxmd.com/read/28178225/poloxamer-based-thermoreversible-gel-for-topical-delivery-of-emodin-influence-of-p407-and-p188-on-solubility-of-emodin-and-its-application-in-cellular-activity-screening
#18
Eunmi Ban, Mijung Park, Seonghee Jeong, Taekhyun Kwon, Eun-Hee Kim, Kiwon Jung, Aeri Kim
Emodin is a component in a Chinese herb, Rheum officinale Baill, traditionally used for diabetes and anticancer. Its poor solubility is one of the major challenges to pharmaceutical scientists. We previously reported on thermoreversible gel formulations based on poloxamer for the topical delivery of emodin. The present study was to understand the effect of poloxamer type on emodin solubility and its application in cellular activity screening. Various gel formulations composed of poloxamer 407 (P407), poloxamer 188 (P188) and PEG400 were prepared and evaluated...
February 7, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28173773/colorectal-cancer-surveillance-in-hodgkin-lymphoma-survivors-at-increased-risk-of-therapy-related-colorectal-cancer-study-design
#19
Lisanne S Rigter, Manon C W Spaander, Leon M Moons, Tanya M Bisseling, Berthe M P Aleman, Jan Paul de Boer, Pieternella J Lugtenburg, Cecile P M Janus, Eefke J Petersen, Judith M Roesink, John M M Raemaekers, Richard W M van der Maazen, Annemieke Cats, Eveline M A Bleiker, Petur Snaebjornsson, Beatriz Carvalho, Iris Lansdorp-Vogelaar, Katarzyna Jóźwiak, Hein Te Riele, Gerrit A Meijer, Flora E van Leeuwen, Monique E van Leerdam
BACKGROUND: Second primary malignancies are a major cause of excess morbidity and mortality in cancer survivors. Hodgkin lymphoma survivors who were treated with infradiaphragmatic radiotherapy and/or high-dose procarbazine have an increased risk to develop colorectal cancer. Colonoscopy surveillance plays an important role in colorectal cancer prevention by removal of the precursor lesions (adenomas) and early detection of cancer, resulting in improved survival rates. Therefore, Hodgkin lymphoma survivors treated with infradiaphragmatic radiotherapy and/or high-dose procarbazine could benefit from colonoscopy, or other surveillance modalities, which are expected to reduce colorectal cancer incidence and mortality...
February 7, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28155016/power-of-screening-tests-for-colorectal-cancer-enhanced-by-high-levels-of-m2-pk-in-addition-to-fobt
#20
Cristina Zaccaro, Ilaria Maria Saracino, Giulia Fiorini, Natale Figura, John Holton, Valentina Castelli, Valeria Pesci, Luigi Gatta, Dino Vaira
Colorectal cancer (CRC) is a multistep process that involves adenoma-carcinoma sequence. CRC can be prevented by routine screening, which can detect precancerous lesions. The aim of this study is to clarify whether faecal occult blood test (i-FOBT), tumor M2 pyruvate kinase (t-M2-PK), and endocannabinoid system molecules (cannabinoid receptors type 1-CB1, type 2-CB2, and fatty acid amide hydrolase-FAAH) might represent better diagnostic tools, alone or in combination, for an early diagnosis of CRC. An immunochemical FOB test (i-FOBT) and quantitative ELISA stool test for t-M2-PK were performed in 127 consecutive patients during a 12 month period...
February 2, 2017: Internal and Emergency Medicine
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