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Colon cancer screening

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https://www.readbyqxmd.com/read/28812930/increasing-colorectal-cancer-screening-at-an-urban-fqhc-using-ifobt-and-patient-navigation
#1
Richard L Martin, Madelaine Tully, Allison Kos, David Frazer, Amy Williamson, Amy Conlon, James J Enser, Noelle K LoConte
INTRODUCTION: Colorectal cancer is the second leading cause of cancer death in the United States. Black Americans suffer even higher incidence and death rates than the general population. Genetics and patient perceptions explain some of this difference, however, modifiable health care system factors such as lack of access to colon cancer screening also contribute. Partnering an academic health center with local community groups, we piloted a colorectal cancer screening program at a Federally Qualified Health Center (FQHC) serving predominately low socioeconomic status Black Americans...
September 2017: Health Promotion Practice
https://www.readbyqxmd.com/read/28811712/association-between-cyp24a1-polymorphisms-and-the-risk-of-colonic-polyps-and-colon-cancer-in-a-chinese-population
#2
Xue-Qi Chen, Jia-Yu Mao, Wen-Bin Li, Jian Li, Hong Yang, Jia-Ming Qian, Jing-Nan Li
AIM: To determine the pathogenesis and potential single nucleotide polymorphisms (SNPs) as screening sites for colonic polyps, colon cancer and ulcerative colitis, and to analyze the possible association between these genetic polymorphisms and the three diseases. METHODS: We evaluated genetic polymorphisms in 144 newly diagnosed colonic polyp patients, 96 colon cancer patients and 44 ulcerative colitis patients. The four SNPs genotyped were rs4809957, rs6068816, rs6091822 and rs8124792...
July 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28811705/colorectal-cancer-screening-an-updated-review-of-the-available-options
#3
REVIEW
Iyad A Issa, Malak Noureddine
Colorectal cancer (CRC) is a significant cause of morbidity and mortality worldwide. However, colon cancer incidence and mortality is declining over the past decade owing to adoption of effective screening programs. Nevertheless, in some parts of the world, CRC incidence and mortality remain on the rise, likely due to factors including "westernized" diet, lifestyle, and lack of health-care infrastructure and resources. Participation and adherence to different national screening programs remain obstacles limiting the achievement of screening goals...
July 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28806741/risk-of-cancer-in-patients-with-genital-warts-a-nationwide-population-based-cohort-study-in-taiwan
#4
Ching-Yi Cho, Yu-Cheng Lo, Miao-Chiu Hung, Chou-Cheng Lai, Chun-Jen Chen, Keh-Gong Wu
BACKGROUND: Condyloma acuminata currently affects around 1% of sexually active adults, and its incidence is increasing. The coexistence of genital warts (GW) and certain cancers and an association between human papillomavirus (HPV) and various malignancies have been reported. Therefore, we conducted this large national study to analyze the risk of malignancies among men and women with GW in Taiwan. METHODS AND FINDINGS: Between January 2000 and December 2013, approximately 3 million patients were reported to the National Health Insurance Research Database of Taiwan...
2017: PloS One
https://www.readbyqxmd.com/read/28798920/new-device-to-implement-the-adenoma-detection-rate
#5
REVIEW
Maddalena Zippi, Wandong Hong, Pietro Crispino, Giampiero Traversa
It is well-known that colonoscopy is considered the gold standard for colon cancer prevention. Although performed by experienced endoscopists, the matter remains of polyps missed during this examination. The reasons may include the size, shape and location of the lesions. Many colorectal cancer screening programs have been proposed to increase the adenoma detection rate. The substantial difference between these methods is whether the improvement in vision, particularly the detection of irregularities of the mucosa, is inside the endoscope electronic components (magnification, wide-angle vision, narrow band imaging, flexible spectral imaging colour enhancement, i-Scan) or outside the same, by the use of specific caps (EndoCuff, EndoVision, EndoRings)...
July 16, 2017: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/28790245/-surgical-case-of-pulmonary-enteric-adenocarcinoma
#6
Shin Shomura, Hitoshi Suzuki, Masaki Yada, Chiaki Kondo
A 59-year-old man consulted our hospital because of an abnormal shadow on a chest computed tomography, located in the right lower lobe. Fluorodeoxyglucose-positron emission tomography showed abnormal uptake in the tumor suggesting lung cancer and right lower lobectomy was performed. Pathological the tumor was diagnosed as lung cancer comprising tall columnar cells. Immunohistochemical staining was positive for TTF-1, CK-7 and CK-20. Postoperative screening of the abdomen revealed no suspicious primary lesion in the colon and the tumor was diagnosed as a pulmonary enteric adenocarcinoma...
August 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/28775166/aneuploid-cell-survival-relies-upon-sphingolipid-homeostasis
#7
Yun-Chi Tang, Hui Yuwen, Kaiying Wang, Peter M Bruno, Kevin Bullock, Amy A Deik, Stefano Santaguida, Marianna Trakala, Sarah J Pfau, Na Zhong, Tao Huang, Lan Wang, Clary B Clish, Michael T Hemann, Angelika Amon
Aneuploidy, a hallmark of cancer cells, poses an appealing opportunity for cancer treatment and prevention strategies. Using a cell-based screen to identify small molecules that could selectively kill aneuploid cells, we identified the compound N-[2-hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl]-decanamide monohydrochloride (DL-PDMP), an antagonist of UDP-glucose ceramide glucosyltransferase. DL-PDMP selectively inhibited proliferation of aneuploid primary mouse embryonic fibroblasts and aneuploid colorectal cancer cells...
August 3, 2017: Cancer Research
https://www.readbyqxmd.com/read/28772302/cancer-risk-in-families-fulfilling-the-amsterdam-criteria-for-lynch-syndrome
#8
N Jewel Samadder, Ken Robert Smith, Jathine Wong, Alun Thomas, Heidi Hanson, Kenneth Boucher, Cathryn Kopituch, Lisa A Cannon-Albright, Randall W Burt, Karen Curtin
Importance: The data describing cancer risks associated with Lynch syndrome are variable. Objectives: To quantify the prevalence of families that fulfill the Amsterdam I or II criteria for Lynch syndrome in the Utah population and investigate the risk of colonic and extracolonic cancers in family members and their relatives. Design, Setting, and Participants: In a population-based study, 202 families with Amsterdam I and II criteria-positive pedigrees in the Utah Population Database were identified...
August 3, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28767389/use-of-confocal-laser-endomicroscopy-with-a-fluorescently-labeled-fatty-acid-to-diagnose-colorectal-neoplasms
#9
Feihong Deng, Yuan Fang, Zhiyong Shen, Wei Gong, Tao Liu, Jing Wen, Wanling Zhang, Xianjun Zhu, Hui Zhong, Tong Wang, Fachao Zhi, Biao Nie
Endoscopic treatment for early colorectal cancer closely correlates with patient prognosis. However, endoscopic differentiation between carcinomas and non-neoplastic lesions remains difficult. Here, we topically stained colorectal neoplasms with a fatty acid analogue (BODIPY-FA) and quantified the fluorescent signals using confocal laser endomicroscopy (CLE) and fluorescence microscopy. We also analyzed protein expression in colorectal cancer tissues. We found that expression of fatty acid synthase was elevated, while the expression of fatty acid transporters was reduced in colorectal cancer...
July 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/28765898/precise-epitope-determination-of-the-anti-vimentin-monoclonal-antibody-v9
#10
Lucia Tomiyama, Hiroki Kamino, Hiroki Fukamachi, Takeshi Urano
Vimentin is a type III intermediate filament protein that is typically expressed in mesenchymal cells. Overexpression of vimentin is frequently observed in several types of cancer and is often associated with epithelial‑to‑mesenchymal transition. It was recently reported that the serum vimentin level is significantly elevated in colon and liver tumors. Therefore, a more sensitive vimentin detection system may be useful for cancer screening and early detection. The V9 mouse monoclonal antibody (mAb), which recognizes the human vimentin protein, is widely used in routine pathology to identify mesenchymal cells using immunohistochemical analysis...
July 27, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28765138/attitudes-on-cost-effectiveness-and-equity-a-cross-sectional-study-examining-the-viewpoints-of-medical-professionals
#11
David G Li, Gordon X Wong, David T Martin, David J Tybor, Jennifer Kim, Jeffrey Lasker, Roger Mitty, Deeb Salem
OBJECTIVE: To determine the attitudes of physicians and trainees in regard to the roles of both cost-effectiveness and equity in clinical decision making. DESIGN: In this cross-sectional study, electronic surveys containing a hypothetical decision-making scenario were sent to medical professionals to select between two colon cancer screening tests for a population. SETTING: Three Greater Boston academic medical institutions: Tufts University School of Medicine, Tufts Medical Centre and Lahey Hospital and Medical Centre...
August 1, 2017: BMJ Open
https://www.readbyqxmd.com/read/28764929/inhibition-of-aurora-kinase-a-induces-necroptosis-in-pancreatic-carcinoma
#12
Yangchun Xie, Shan Zhu, Meizuo Zhong, Minghua Yang, Xiaofan Sun, Jinbao Liu, Guido Kroemer, Michael Lotze, Herbert J Zeh, Rui Kang, Daolin Tang
BACKGROUND & AIMS: Induction of non-apoptotic cell death could be an approach to eliminate apoptosis-resistant tumors. We investigated necroptosis-based therapies in mouse models of pancreatic ductal adenocarcinoma cancer (PDAC). METHODS: We screened 273 commercially available kinase inhibitors for cytotoxicity against a human PDAC cell line (PANC1). We evaluated the ability of the aurora kinase inhibitor CCT137690 to stimulate necroptosis in PDAC cell lines (PANC1, PANC2...
July 29, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28764731/evaluation-of-the-colorectal-cancer-screening-programme-in-the-basque-country-spain-and-its-effectiveness-based-on-the-miscan-colon-model
#13
I Idigoras, A Arrospide, I Portillo, E Arana-Arri, L Martínez-Indart, J Mar, H J de Koning, R Lastra, M Soto-Gordoa, M van der Meulen, I Lansdorp-Vogelaar
The population-based Basque Colorectal Cancer (CRC) Screening Programme started in 2009 with a biennial immunochemical quantitative test (FIT) biennial and colonoscopy under sedation in positive cases. The population target of 586,700 residents was from 50 to 69 years old and the total coverage was reached at the beginning of 2014. The aim of our study was to determine possible scenarios in terms of incidence, mortality and reduction of Life-years-Lost (L-y-L) in the medium and long term of CRC. METHODS: Invitations were sent out by the Programme from 2009 to 2014, with combined organizational strategies...
August 1, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28763808/endocuff-assisted-colonoscopy-is-associated-with-a-lower-adenoma-miss-rate-a-multicenter-randomized-tandem-study
#14
Konstantinos Triantafyllou, Dimitrios Polymeros, Periklis Apostolopoulos, Catarina Lopes Brandao, Paraskevas Gkolfakis, Alessandro Repici, Ioannis S Papanikolaou, Mario Dinis-Ribeiro, George Alexandrakis, Cesare Hassan
Background and study aims The Endocuff (ARC Medical Design, Leeds, UK) is a device that, when mounted on the tip of an endoscope, may assist with inspection of a greater surface of the colonic mucosa by pulling backwards, flattening, and stretching the colonic folds as the endoscope is gradually withdrawn. We aimed to compare the adenoma miss rates of Endocuff-assisted colonoscopy with those of conventional colonoscopy. Patients and methods The included patients underwent same-day, back-to-back, (Endocuff-assisted colonoscopy as the index procedure followed by conventional colonoscopy or vice versa, randomly assigned 1:1) colonoscopies, performed by six endoscopists with documented adenoma detection rates > 35 %, in four tertiary endoscopy facilities...
August 1, 2017: Endoscopy
https://www.readbyqxmd.com/read/28761604/-colon-adenocarcinoma-and-synchronous-type-1-papillary-renal-cell-carcinoma-a-unique-association
#15
Asma Sassi, Dhouha Bacha, Ghofrane Talbi, Sana Ben Slama, Rahma Boughriba, Zeineb Mzoughi, Saadia Bouraoui, Ahlem Lahmar
The detection of primary tumors synchronous with colorectal cancer has been the subject of multiple publications. This association can occur sporadically or fall under the framework of well defined clinical syndromes such as Lynch syndrome. Synchronous association of colorectal cancer (CRC) and renal cell carcinoma is rare. It is even more rare when renal cell carcinoma is of papillary origin, with only 2 cases reported in the literature. The association between CRC and renal cell carcinoma does not seem to be related to mismatch repair proteins (MMR) abnormality and does not include, up to now, any clinical syndrome...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28759878/thienopyrimidine-derivatives-exert-their-anticancer-efficacy-via-apoptosis-induction-oxidative-stress-and-mitotic-catastrophe
#16
Haneen Amawi, Chandrabose Karthikeyan, Rekha Pathak, Noor Hussein, Ryann Christman, Robert Robey, Charles R Ashby, Piyush Trivedi, Ashim Malhotra, Amit K Tiwari
In this study, a series of 13 structural variants of thieno[2,3d]pyrimidine derivatives (6a-6m) were synthesized and screened for cytotoxicity in a panel of colorectal, ovarian, and brain cancer cell lines. The selectivity of the compounds was assessed by determining the cytotoxicity in normal epithelial cell line (CHO). The most potent compound, 6j, was efficacious (with IC50 range of 0.6-1.2 μM) in colon (HCT116 and HCT15), brain (LN-229 and GBM-10) and ovarian (A2780 and OV2008) cancer cell lines. In contrast, in the normal cell line (CHO), the IC50 values for 6j were 14 ± 1...
July 20, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28753106/colorectal-adenoma-and-cancer-detection-based-on-altered-methylation-pattern-of-sfrp1-sfrp2-sdc2-and-prima1-in-plasma-samples
#17
Barbara Kinga Barták, Alexandra Kalmár, Bálint Péterfia, Árpád V Patai, Orsolya Galamb, Gábor Valcz, Sándor Spisák, Barnabás Wichmann, Zsófia Brigitta Nagy, Kinga Tóth, Zsolt Tulassay, Péter Igaz, Béla Molnár
Aberrant methylation is one of the most frequent epigenetic alterations that can contribute to tumor formation. Cell-free DNA can originate from tumor tissue; therefore, the evaluation of methylation markers in cell-free DNA can be a promising method for cancer screening. Our aim was to develop a panel of biomarkers with altered methylation along colorectal adenoma-carcinoma sequence in both colonic tissue and plasma. The methylation of selected CpG sites in healthy colonic (n = 15), adenoma (n = 15), and colorectal cancer (n = 15) tissues was analyzed by pyrosequencing...
July 28, 2017: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/28747791/molecular-imaging-of-aberrant-crypt-foci-in-the-human-colon-targeting-glutathione-s-transferase-p1-1
#18
Naoki Muguruma, Koichi Okamoto, Tadahiko Nakagawa, Katsutaka Sannomiya, Shota Fujimoto, Yasuhiro Mitsui, Tetsuo Kimura, Hiroshi Miyamoto, Jun Higashijima, Mitsuo Shimada, Yoko Horino, Shinya Matsumoto, Kenjiro Hanaoka, Tetsuo Nagano, Makoto Shibutani, Tetsuji Takayama
Aberrant crypt foci (ACF), the earliest precursor lesion of colorectal cancers (CRCs), are a good surrogate marker for CRC risk stratification and chemoprevention. However, the conventional ACF detection method with dye-spraying by magnifying colonoscopy is labor- and skill-intensive. We sought to identify rat and human ACF using a fluorescent imaging technique that targets a molecule specific for ACF. We found that glutathione S-transferase (GST) P1-1 was overexpressed in ACF tissues in a screening experiment...
July 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28747187/general-practitioners-views-and-preferences-about-quality-improvement-feedback-in-preventive-care-a-cross-sectional-study-in-switzerland-and-france
#19
Paul Sebo, Hubert Maisonneuve, Jean-Pascal Fournier, Nicolas Senn, Dagmar M Haller
BACKGROUND: Feedback is widely used as a strategy to improve the quality of care in primary care settings. As part of a study conducted to explore the quality of preventive care, we investigated general practitioners' (GPs) views on the usefulness of feedback and their preferences regarding how feedback is provided. METHODS: This cross-sectional study was conducted in 2015 among randomly selected community-based GPs in two regions of Switzerland and France. GPs were asked to complete an anonymous questionnaire about how often they provided 12 measures of preventive care: blood pressure, weight and height measurements, screening for dyslipidemia, at-risk drinking (and advice to reduce for at-risk drinkers), smoking (and advice to stop for smokers), colon and prostate cancer, and influenza immunization for patients >65 years and at-risk patients...
July 26, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/28743561/increased-prevalence-of-colonic-adenomas-in-patients-with-cystic-fibrosis
#20
Mehdi Hegagi, Shawn D Aaron, Paul James, Rakesh Goel, Avijit Chatterjee
BACKGROUND: Cystic fibrosis (CF) is the most common lethal genetic illness in the Caucasian population. Studies have shown that CF patients are at an elevated risk of developing colon cancer. Colonic adenomas are the precursors of colon cancer. This study aims to determine the prevalence of adenomas in patients with cystic fibrosis. METHODS: All patients were recruited prospectively at The Ottawa Hospital Cystic Fibrosis Clinic from 2010 through 2015. Baseline demographic and cystic fibrosis disease characteristics were collected from the clinic's CF patient database...
July 22, 2017: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
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