Yashuhiro Arakawa, Ukhyun Jo, Suresh Kumar, Nai-Yun Sun, Fathi Elloumi, Anish Thomas, Nitin Roper, Diana Grace Varghese, Naoko Takebe, Xiaohu Zhang, Michele Ceribelli, David O Holland, Erin Beck, Zina Itkin, Crystal McKnight, Kelli M Wilson, Jameson Travers, Carleen Klumpp-Thomas, Craig J Thomas, Chuong D Hoang, Jonathan M Hernandez, Jaydira Del Rivero, Yves Pommier
Current treatment options for metastatic adrenocortical carcinoma (ACC) have limited efficacy, despite the common use of mitotane and cytotoxic agents. This study aimed to identify novel therapeutic options for ACC. An extensive drug screen was conducted to identify compounds with potential activity against ACC cell lines. We further investigated the mechanism of action of the identified compound, TAK-243, its synergistic effects with current ACC therapeutics, and its efficacy in ACC models including patient-derived organoids and mouse xenografts...
March 7, 2024: Cancer Res Commun