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https://www.readbyqxmd.com/read/28730315/comparison-of-nellcor%C3%A2-pm1000n-and-masimo-radical-7-%C3%A2-for-detecting-apnea-in-volunteers
#1
Chanatthee Kitsiripant, Tomoko Fukada, Hiroko Iwakiri, Yuri Tsuchiya, Makoto Ozaki, Minoru Nomura
PURPOSE: Although capnography is considered the gold standard for monitoring of ventilation, it may not work accurately in some situations. We compared the performance of two non-invasive continuous respiratory rate (RR) monitors that are alternatives for the detection of respiratory depression. METHODS: Fifty healthy volunteers ≥20 years old were enrolled in this study. After monitoring of the volunteers was started by the Masimo Radical-7(®) and Nellcor™ PM1000N, they breathed at the rate of 12 breaths/min for 3 min and then stopped breathing...
July 20, 2017: Journal of Anesthesia
https://www.readbyqxmd.com/read/28729630/mechanically-durable-liquid-impregnated-honeycomb-surfaces
#2
Philip S Brown, Bharat Bhushan
Liquid repellent surfaces typically work by keeping the fouling liquid in a metastable state, with trapped pockets of air between the substrate and the liquid. An alternative method with greater long-term stability utilizes liquid-impregnated surfaces, where the liquid being repelled slides over an immiscible liquid immobilized on a porous surface. Here, we report a method for creating honeycomb surfaces amenable to liquid-impregnation. Polystyrene dissolved in a water-immiscible, volatile solvent was deposited in a humid environment on a variety of substrates to achieve the necessary porosity...
July 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28716147/stop-smoking-and-alcohol-drinking-before-operation-for-bladder-cancer-%C3%AF-the-stop-op-study-%C3%AF-perioperative-smoking-and-alcohol-cessation-intervention-in-relation-to-radical-cystectomy-study-protocol-for-a-randomised-controlled-trial
#3
Susanne Vahr Lauridsen, Thordis Thomsen, Peter Thind, Hanne Tønnesen
BACKGROUND: To evaluate the effect of a smoking-, alcohol- or combined-cessation intervention starting shortly before surgery and lasting 6 weeks on overall complications after radical cystectomy. Secondary objectives are to examine the effect on types and grades of complications, smoking cessation and alcohol cessation, length of hospital stay, health-related quality of life and return to work or habitual level of activity up to 12 months postoperatively. METHODS/DESIGN: The study is a multi-institutional randomised clinical trial involving 110 patients with a risky alcohol intake and daily smoking who are scheduled for radical cystectomy...
July 17, 2017: Trials
https://www.readbyqxmd.com/read/28715576/association-of-ozone-exposure-with-cardiorespiratory-pathophysiologic-mechanisms-in-healthy-adults
#4
Drew B Day, Jianbang Xiang, Jinhan Mo, Feng Li, Mingkei Chung, Jicheng Gong, Charles J Weschler, Pamela A Ohman-Strickland, Jan Sundell, Wenguo Weng, Yinping Zhang, Junfeng Jim Zhang
Importance: Exposure to ozone has been associated with cardiovascular mortality, but the underlying biological mechanisms are not yet understood. Objective: To examine the association between ozone exposure and cardiopulmonary pathophysiologic mechanisms. Design, Setting, and Participants: A longitudinal study involving 89 healthy adult participants living on a work campus in Changsha City, China, was conducted from December 1, 2014, to January 31, 2015...
July 17, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28715132/return-of-neonatal-cpap-resistance-the-medijet-device-family-examined-using-in-vitro-flow-simulations
#5
M Falk, S Donaldsson, B Jonsson, T Drevhammar
AIM: Medijet nasal continuous positive airway pressure (CPAP) generators are a family of devices developed from the Benveniste valve. Previous studies have shown that the in-vitro performance of the Medijet disposable generator was similar to the Neopuff resistor system. We hypothesised that resistance would be the main mechanism of CPAP generation in the Medijet disposable generator. METHODS: The in-vitro performance of the Medijet reusable and disposable systems, the Neopuff resistor system and the Benveniste and Infant Flow non-resistor systems were investigated using static and dynamic bench tests...
July 17, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28713464/a-rapidly-incremented-tethered-swimming-test-for-defining-domain-specific-training-zones
#6
Dalton M Pessôa Filho, Leandro O C Siqueira, Astor R Simionato, Mário A C Espada, Daniel S Pestana, Fred J DiMenna
The purpose of this study was to investigate whether a tethered-swimming incremental test comprising small increases in resistive force applied every 60 seconds could delineate the isocapnic region during rapidly-incremented exercise. Sixteen competitive swimmers (male, n = 11; female, n = 5) performed: (a) a test to determine highest force during 30 seconds of all-out tethered swimming (Favg) and the ΔF, which represented the difference between Favg and the force required to maintain body alignment (Fbase), and (b) an incremental test beginning with 60 seconds of tethered swimming against a load that exceeded Fbase by 30% of ΔF followed by increments of 5% of ΔF every 60 seconds...
June 2017: Journal of Human Kinetics
https://www.readbyqxmd.com/read/28711371/extubation-to-high-flow-nasal-cannula-in-critically-ill-surgical-patients
#7
Navpreet K Dhillon, Eric J T Smith, Ara Ko, Megan Y Harada, Danielle Polevoi, Richard Liang, Galinos Barmparas, Eric J Ley
BACKGROUND: High-flow nasal cannula (HFNC) is increasingly used to reduce reintubations in patients with respiratory failure. Benefits include providing positive end expiratory pressure, reducing anatomical dead space, and decreasing work of breathing. We sought to compare outcomes of critically ill surgical patients extubated to HFNC versus conventional therapy. METHODS: A retrospective review was conducted in the surgical intensive care unit of an academic center during August 2015 to February 2016...
July 12, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28707209/anaesthetic-preparation-of-obese-patients-current-status-on-optimal-work-up
#8
REVIEW
Asta Lukosiute, Anil Karmali, Jonathan Mark Cousins
PURPOSE OF REVIEW: With the prevalence of obesity rapidly growing, bariatric anaesthesia becomes everyday anaesthesia rather than a subspecialty. In this review, we are aiming to draw attention to this complex group of patients and their comorbidities, relevant to everyday practice for contemporary anaesthetists. RECENT FINDINGS: We wanted to focus greatly on sleep-related breathing disorders, because preoperative screening, diagnosis and treatment of the aforementioned make a huge impact in the improvement of preoperative morbidity and mortality, including positive effects on the cardiovascular system...
July 13, 2017: Current Obesity Reports
https://www.readbyqxmd.com/read/28703117/early-diagnostics-of-temporomandibular-joint-structural-elements-injures-caused-by-traumatic-mandibular-bone-fractures
#9
Kh R Pohranychna, A R Stasyshyn, U D Matolych
A rapidly increasing number of mandibular condylar fractures and some complications related to injuries of temporomandibular elements make this study important. Intra-articular disorders lead to secondary pathological findings such as osteoarthritis, deforming osteoarthrosis, and temporomandibular joint ankylosis that limits mouth opening, mastication, swallowing, breathing, and decreased/lost working capacity or disability. Early diagnosis of intra-articular disorders can prevent from long-lasting functional complications caused by temporomandibular joint injuries...
June 30, 2017: Polski Przeglad Chirurgiczny
https://www.readbyqxmd.com/read/28698373/genetic-identification-of-a-hindbrain-nucleus-essential-for-innate-vocalization
#10
Luis Rodrigo Hernandez-Miranda, Pierre-Louis Ruffault, Julien C Bouvier, Andrew J Murray, Marie-Pierre Morin-Surun, Niccolò Zampieri, Justyna B Cholewa-Waclaw, Elodie Ey, Jean-Francois Brunet, Jean Champagnat, Gilles Fortin, Carmen Birchmeier
Vocalization in young mice is an innate response to isolation or mechanical stimulation. Neuronal circuits that control vocalization and breathing overlap and rely on motor neurons that innervate laryngeal and expiratory muscles, but the brain center that coordinates these motor neurons has not been identified. Here, we show that the hindbrain nucleus tractus solitarius (NTS) is essential for vocalization in mice. By generating genetically modified newborn mice that specifically lack excitatory NTS neurons, we show that they are both mute and unable to produce the expiratory drive required for vocalization...
July 11, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28693357/effect-of-acute-ambient-temperature-exposure-on-cardio-pulmonary-and-respiratory-kinetics-in-men
#11
U Drescher, J Koschate, U Hoffmann, S Schneider, A Werner
PURPOSE: The goal of the study was to compare the kinetics responses of heart rate (HR) and pulmonary (V'O2pulm) and muscular (V'O2musc) oxygen uptake during dynamic leg exercise across different acute ambient temperature conditions in a climatic chamber. METHODS: Thirteen physically healthy, active male volunteers performed pseudo-random binary sequence (PRBS) work rate (WR) changes between 30 W and 80 W at 15°C, 25°C and 35°C, respectively. HR was measured beat-to-beat by echocardiogram and V'O2pulm by breath-by-breath gas exchange, and V'O2musc estimations were assessed by applying a circulatory model and cross-correlation functions based on the approach of Hoffmann et al...
July 10, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28689383/-apnea-of-prematurity-characteristic-and-treatment
#12
Aleksandra Goryniak, Angelika Szczęśniak, Daria Śleboda, Barbara Dołęgowska
Apnea of prematurity (AOP) can affect even 85-100% of premature newborns and is related to lack of full maturity of organs. AOP is manifesting by 15-20 seconds cessations of breathing accompanied by bradycardia and oxygen desaturation, what can lead to hypoxia or death. Therefore it is very important to implement the effective and safe treatment immediately after birth. Widely used caffeine citrate, which stimulates the respiratory system, improving the working of the respiratory muscles. However the metabolism of caffeine citrate is difficult in preterm infants due to the immaturity of the hepatic enzyme system, what can lead to the occurrence of side effects and toxicity...
2017: Postepy Biochemii
https://www.readbyqxmd.com/read/28688537/calculated-ventilation-and-effort-distribution-as-a-measure-of-respiratory-disease-and-heliox-effectiveness
#13
N Pozin, S Montesantos, I Katz, M Pichelin, C Grandmont, I Vignon-Clementel
In spite of numerous clinical studies, there is no consensus on the benefit Heliox mixtures can bring to asthmatic patients in terms of work of breathing and ventilation distribution. In this article we use a 3D finite element mathematical model of the lung to study the impact of asthma on effort and ventilation distribution along with the effect of Heliox compared to air. Lung surface displacement fields extracted from computed tomography medical images are used to prescribe realistic boundary conditions to the model...
June 23, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28688290/the-efficacy-of-plant-extract-and-bioactive-compounds-approaches-in-the-treatment-of-pulmonary-fibrosis-a-systematic-review
#14
REVIEW
Sana Bahri, Ridha Ben Ali, Anouar Abidi, Saloua Jameleddine
Pulmonary fibrosis (PF) is a lethal, chronic and progressive respiratory disease leading to interstitial lung damage and serious breathing problems. The pathogenic mechanism involves activation, migration, proliferation and differentiation of fibroblasts into myofibroblats inducing extracellular matrix accumulation that destroy lung parenchyma. Available antifibrotic treatment options are limited to Pirfenidone and Nintedanib that prevent deterioration without an improvement of this disease. The use of plant extracts and natural bioactive compounds for the treatment of PF has been known for more than thirty years in China...
July 5, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28687586/a-rash-with-a-heavy-heart
#15
Sergio Barros-Gomes, Niyada Naksuk, Dragan Jevremovic, Hector R Villarraga
Cardiac amyloidosis (CA) is relatively rare and frequently misdiagnosed. Other disorders presenting with increased left ventricular (LV) mass can mimic its diagnosis. This case illustrates unique findings of primary light chain (AL) amyloidosis in a patient with remarkable signs of CA. Here, we report a 49-year-old man with prior diagnosis of hypertrophy cardiomyopathy (HCM) based on an echocardiogram performed 1 year earlier that presented with 8 weeks of periorbital rash. He had numbness in the past 3 years...
July 7, 2017: Echo Research and Practice
https://www.readbyqxmd.com/read/28687449/jp8-exposure-and-neurocognitive-performance-among-us-air-force-personnel
#16
Kristin J Heaton, Alexis L Maule, Kristen W Smith, Ema G Rodrigues, Michael D McClean, Susan P Proctor
Petroleum-based fuels such as jet propellant (JP) 4, JP5, JP8, and jet A1 (JetA) are among the most common occupational chemical exposures encountered by military and civilian workforces. Although acute toxicity following high-level exposures to JP8 and similar chemical mixtures has been reported, the relationship between persistent low-level occupational exposures to jet fuels and both acute and longer-term central nervous system (CNS) function has been comparatively less well characterized. This paper describes results of neurocognitive assessments acquired repeatedly across a work week study design (Friday to Friday) as part of the Occupational JP8 Exposure Neuroepidemiology Study (OJENES) involving U...
July 4, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28686810/self-calibrated-correlation-imaging-with-k-space-variant-correlation-functions
#17
Yu Li, Masoud Edalati, Xingfu Du, Hui Wang, Jie J Cao
PURPOSE: Correlation imaging is a previously developed high-speed MRI framework that converts parallel imaging reconstruction into the estimate of correlation functions. The presented work aims to demonstrate this framework can provide a speed gain over parallel imaging by estimating k-space variant correlation functions. METHODS: Because of Fourier encoding with gradients, outer k-space data contain higher spatial-frequency image components arising primarily from tissue boundaries...
July 7, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28684394/tg-th-cre-fi172gsat-th-cre-defines-neurons-that-are-required-for-full-hypercapnic-and-hypoxic-reflexes
#18
Jenny J Sun, Russell S Ray
The catecholaminergic system has been implicated in many facets of breathing control and offers an important target to better comprehend the underlying etiologies of both developmental and adult respiratory pathophysiologies. Here we used a noninvasive DREADD based pharmaco-genetic approach to acutely perturb Tg(Th-Cre)FI172Gsat (Th-Cre) defined neurons in awake and unrestrained mice in an attempt to characterize catecholaminergic function in breathing. We report that clozapine-N-oxide (CNO)-DREADD mediated inhibition of Th-Cre defined neurons results in blunted ventilatory responses under respiratory challenge...
July 6, 2017: Biology Open
https://www.readbyqxmd.com/read/28683222/application-of-a-one-dimensional-computational-model-for-the-prediction-of-deposition-from-a-dry-powder-inhaler
#19
Konstantinos Gourgoulianis, Zoi Daniil, Katerina Athanasiou, Stavroula Rozou, Vasileios Bontozoglou
BACKGROUND: Accurate prediction of the regional deposition of inhaled dry powders as a function of powder properties and breathing pattern is a long-term research goal for pulmonary drug delivery. In the present work, deposition along the respiratory tract of dry powders of Fluticasone propionate and Salmeterol is predicted. METHODS: A one-dimensional particle transport and deposition model is used, whose novelty is in the treatment of the alveolar space of each airway generation as an efficient mixing chamber...
July 6, 2017: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/28682818/respiratory-problems-in-low-resource-settings
#20
Mhoira E F Leng, Sunitha Daniel, Daniel Munday
PURPOSE OF REVIEW: Chronic breathlessness is common in patients with advanced illness who require palliative care. Achieving good symptom control can be challenging. More people with advanced illness live in low and middle income than in high-income countries, but they are much less likely to receive palliative care. Most of the emerging evidence for the palliative management of chronic breathlessness is from high-income countries. This review explores the context of chronic breathlessness in low-income settings, how evidence for control of chronic breathlessness might relate to these settings and where further work should be focused...
July 5, 2017: Current Opinion in Supportive and Palliative Care
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