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https://www.readbyqxmd.com/read/28434138/dynamic-epr-oximetry-of-changes-in-intracerebral-oxygen-tension-during-induced-thromboembolism
#1
Huagang Hou, Nadeem Khan, Sangeeta Gohain, Clifford J Eskey, Karen L Moodie, Kirk J Maurer, Harold M Swartz, Periannan Kuppusamy
Cerebral tissue oxygenation (oxygen tension, pO2) is a critical parameter that is closely linked to brain metabolism, function, and pathophysiology. In this work, we have used electron paramagnetic resonance oximetry with a deep-tissue multi-site oxygen-sensing probe, called implantable resonator, to monitor temporal changes in cerebral pO2 simultaneously at four sites in a rabbit model of ischemic stroke induced by embolic clot. The pO2 values in healthy brain were not significantly different among the four sites measured over a period of 4 weeks...
April 22, 2017: Cell Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28431823/sleepiness-and-activity-in-heart-failure-patients-with-reduced-ejection-fraction-and-central-sleep-disordered-breathing
#2
Angela Atalla, Thomas W Carlisle, Anita K Simonds, Martin R Cowie, Mary J Morrell
OBJECTIVE: Patients with heart failure (HF) and sleep disordered breathing (SDB) are typically not sleepy, unlike patients without heart failure. Previous work in HF patients with obstructive SDB suggested that sleepiness was associated with a reduction in daytime activity. The consequences of predominately central SDB on sleepiness in HF are less well understood. The aim of this study was to test the hypothesis that subjective sleepiness is associated with reduced daytime activity in HF patients with central SDB, compared to those without SDB...
January 23, 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28428678/productive-cough-in-children-and-adolescents-view-from-primary-health-care-system
#3
REVIEW
Edin Begic, Zijo Begic, Amra Dobraca, Edo Hasanbegovic
Cough is one of the most common symptoms that doctor faces in working with pediatric population, and according to some characteristics of cough, doctors can often conclude localization, and sometimes even the nature of the disease that causes it. Cough is not only the physiological defense reaction, but a symptom of a disease. According to duration it can be acute, chronic and recidivist, recurrent and persistent, strong or discreet, caused by changes in body position and changes in outside temperature. Pathoanatomically it is divided into lobar, lobular, alveolar and interstitial, pathogenetically to bronchogenic and hematogenous, as well as in immuno competent and immunocompromised, and clinically on the local and inpatient (72 hours after hospital admission)...
February 2017: Medical Archives
https://www.readbyqxmd.com/read/28424359/effects-of-combined-tiotropium-olodaterol-on-inspiratory-capacity-and-exercise-endurance-in-copd
#4
Denis E O'Donnell, Richard Casaburi, Peter Frith, Anne Kirsten, Dorothy De Sousa, Alan Hamilton, Wenqiong Xue, François Maltais
Two replicate, double-blind, 6-week, incomplete-crossover studies (MORACTO 1 and 2) assessed the effects of tiotropium/olodaterol on inspiratory capacity and exercise endurance time in patients with moderate to severe chronic obstructive pulmonary disease.For each patient, four of five treatments were administered once daily for 6 weeks, with a 21-day washout between treatments: tiotropium/olodaterol 2.5/5 µg or 5/5 µg, tiotropium 5 µg, olodaterol 5 µg or placebo, all via the Respimat inhaler...
April 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28421912/a-survey-of-school-nurse-emergency-preparedness-2014-2015
#5
Margaret R Ugalde, Danielle Guffey, Charles G Minard, Angelo P Giardino, Gwendolyn A Johnson
Well-prepared school nurses are more likely to handle emergencies properly. Thus, assessing crisis management preparedness is important. In August 2014, a questionnaire was sent to 275 nurses in a large Texas school system to collect data about nurse and school characteristics, emergency frequency and management, and equipment availability. Completed surveys (201, 73%) were analyzed. Fisher's exact test was used to evaluate comparisons among nurses' confidence levels, school characteristics, emergencies, and medical emergency response plans (MERP)...
January 1, 2017: Journal of School Nursing: the Official Publication of the National Association of School Nurses
https://www.readbyqxmd.com/read/28421364/an-ovine-in-vivo-framework-for-tracheobronchial-stent-analysis
#6
Donnacha J McGrath, Anja Lena Thiebes, Christian G Cornelissen, Mary B O'Shea, Barry O'Brien, Stefan Jockenhoevel, Mark Bruzzi, Peter E McHugh
Tracheobronchial stents are most commonly used to restore patency to airways stenosed by tumour growth. Currently all tracheobronchial stents are associated with complications such as stent migration, granulation tissue formation, mucous plugging and stent strut fracture. The present work develops a computational framework to evaluate tracheobronchial stent designs in vivo. Pressurised computed tomography is used to create a biomechanical lung model which takes into account the in vivo stress state, global lung deformation and local loading from pressure variation...
April 19, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28419591/application-of-spin-echoes-in-the-regime-of-weak-dephasing-to-t1-mapping-of-the-lung
#7
Jakob Assländer, Steffen J Glaser, Jürgen Hennig
PURPOSE: This work presents an approach to mapping the entire lung's proton density and T1 within a single breath-hold and analyzes the apparent T1 when exciting with a spin echo generating pulse in comparison to a standard gradient echo acquisition. METHODS: An inversion-recovery SNAPSHOT-FLASH sequence with a stack-of-stars k-space readout with a golden angle increment was modified to use a spin echo generating radiofrequency-pulse for excitation. Data of five volunteers were acquired on a 3T scanner and image reconstruction was performed by an iterative algorithm adopted from MR-Fingerprinting...
April 17, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28419582/free-breathing-liver-fat-quantification-using-a-multiecho-3d-stack-of-radial-technique
#8
Tess Armstrong, Isabel Dregely, Alto Stemmer, Fei Han, Yutaka Natsuaki, Kyunghyun Sung, Holden H Wu
PURPOSE: The diagnostic gold standard for nonalcoholic fatty liver disease is an invasive biopsy. Noninvasive Cartesian MRI fat quantification remains limited to a breath-hold (BH). In this work, a novel free-breathing 3D stack-of-radial (FB radial) liver fat quantification technique is developed and evaluated in a preliminary study. METHODS: Phantoms and healthy subjects (n = 11) were imaged at 3 Tesla. The proton-density fat fraction (PDFF) determined using FB radial (with and without scan acceleration) was compared to BH single-voxel MR spectroscopy (SVS) and BH 3D Cartesian MRI using linear regression (correlation coefficient ρ and concordance coefficient ρc ) and Bland-Altman analysis...
April 16, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28416458/on-the-origins-of-sex-based-differences-in-respiratory-disorders-lessons-and-hypotheses-from-stress-neuroendocrinology-in-developing-rats
#9
REVIEW
Jean-Philippe Rousseau, Luana Tenorio-Lopes, Cécile Baldy, Tara Adele Janes, Stéphanie Fournier, Richard Kinkead
The environment plays a critical role in shaping development and function of the brain. Stress, especially when experienced early in life, can interfere with these processes. In the context of respiratory control, perinatal stress can therefore alter the ability to achieve the "fine-tuning" necessary for proper detection of chemosensory stimuli and production of an adequate motor (respiratory) command. Depending on the timing, intensity, and duration, the detrimental consequences of perinatal exposure to adverse conditions on the respiratory network become manifest at various life stages and can persist into adulthood...
April 14, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28415460/poly-arginine-graphene-quantum-dots-as-a-biocompatible-and-non-toxic-nanocomposite-layer-by-layer-electrochemical-preparation-characterization-and-non-invasive-malondialdehyde-sensory-application-in-exhaled-breath-condensate
#10
Mohammad Hasanzadeh, Fozieh Mokhtari, Nasrin Shadjou, Aziz Eftekhari, Ahad Mokhtarzadeh, Vahid Jouyban-Gharamaleki, Soltanali Mahboob
This study reports on the electropolymerization of a low toxic and biocompatible polymer with entitle poly arginine-graphene quantum dots (PARG-GQDs) as a novel strategy for surface modification of glassy carbon (GC) surface and preparation a new interface for biomedical application. The fabrication of PARG-GQDs on GCE was performed using Layer-by-layer regime. Scanning electron microscopy (SEM) was confirmed dispersion of GQDs on the surface of PARG which lead to increase of surface coverage of PARG. The redox behavior of prepared sensor was then characterized by cyclic voltammetry (CV), differential pulse voltammetry (DPV) and chronoamperometry (CHA), square wave voltammetry (SWV), linear sweep voltammetry (LSV)...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28414674/a-clot-possibly-due-to-loss-of-tnf-%C3%AE-supression
#11
J Broussard, M Berlinger, D Lauret
INTRODUCTION: Inflammation and venous thrombosis enjoy a close Relationship. We present a patient who had multiple DVTs following the discontinuation of anti- TNF-α therapy. CASE: A 34 year old African American female with a history of multiple DVT's, miscarriages, and reported Crohn's disease presented with shortness of breath. In the Emergency Department, CTA showed bilateral pulmonary emboli. The patient had been off adalimumab for one year and reported abdominal pain with 6-7 non-bloody bowel movements daily...
March 2017: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/28413228/air-breathing-cathodes-for-microbial-fuel-cell-using-mn-fe-co-and-ni-containing-platinum-group-metal-free-catalysts
#12
Mounika Kodali, Carlo Santoro, Alexey Serov, Sadia Kabir, Kateryna Artyushkova, Ivana Matanovic, Plamen Atanassov
The oxygen reduction reaction (ORR) is one of the major factors that is limiting the overall performance output of microbial fuel cells (MFC). In this study, Platinum Group Metal-free (PGM-free) ORR catalysts based on Fe, Co, Ni, Mn and the same precursor (Aminoantipyrine, AAPyr) were synthesized using identical sacrificial support method (SSM). The catalysts were investigated for their electrochemical performance, and then integrated into an air-breathing cathode to be tested in "clean" environment and in a working microbial fuel cell (MFC)...
March 20, 2017: Electrochimica Acta
https://www.readbyqxmd.com/read/28411827/sensitive-determination-of-malondialdehyde-in-exhaled-breath-condensate-and-biological-fluids-by-capillary-electrophoresis-with-laser-induced-fluorescence-detection
#13
Júlia Lačná, František Foret, Petr Kubáň
In this work, a sensitive capillary electrophoresis method with laser induced fluorescence detection for determination of malondialdehyde in various biological fluids was developed. Malondialdehyde reacts with thiobarbituric acid under optimized conditions of pH=2, reaction time of 60min and temperature of 90°C, yielding an adduct that can be separated in a 50mM sodium borate background electrolyte at pH 9. The separation of the formed adduct was accomplished in less than 6min with limit of detection of 1...
July 1, 2017: Talanta
https://www.readbyqxmd.com/read/28406091/daptomycin-associated-eosinophilic-pneumonia-with-rechallenge-a-case-report%C3%A2
#14
Melanie Nickerson, Ashish Bhargava, Pramodini B Kale-Pradhan
PURPOSE: A case of daptomycin-associated acute eosinophilic pneumonia (AEP) with positive rechallenge is reported. SUMMARY: AEP associated with daptomycin is reported in the literature, and the product labeling contains a warning and precaution statement. Criteria for diagnosing daptomycin-induced AEP varies and generally includes bronchoalveolar lavage (BAL) eosinophils ≥ 25%. We report a case of a 70-year-old woman with cough, shortness of breath, and altered mental status who presented ~ 9 days after starting therapy with daptomycin to treat methicillin-resistant Staphylococcus aureus (MRSA) osteomyelitis...
April 13, 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28399443/the-effect-of-inspiratory-and-expiratory-loads-on-abdominal-muscle-activity-during-breathing-in-subjects-at-risk-for-the-development-of-chronic-obstructive-pulmonary-disease-and-healthy
#15
António Mesquita Montes, Carlos Crasto, Cristina Argel de Melo, Rita Santos, Susana Pereira, João Paulo Vilas-Boas
The abdominal muscle activity has been shown to be variable in subjects with chronic obstructive pulmonary disease (COPD) when respiratory demand increases and their recruitment pattern may change the mechanics, as well as the work and cost of breathing. The scientific evidence in subjects "at risk" for the development of COPD may be important to understand the natural history of this disease. This study aims to evaluate the effect of inspiratory and expiratory loads on the abdominal muscle activity during breathing in subjects "at risk" for the development of COPD and healthy...
March 31, 2017: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/28371844/diesel-exhaust-exposure-assessment-among-tunnel-construction-workers-correlations-between-nitrogen-dioxide-respirable-elemental-carbon-and-particle-number
#16
Maria Hedmer, Aneta Wierzbicka, Huiqi Li, Maria Albin, Håkan Tinnerberg, Karin Broberg
Objectives: Occupational exposure to diesel exhaust is common due the widespread use of diesel-powered combustion engines. Diesel exhaust is chemically complex and consists of thousands of compounds present as gases and particulate matter. Both nitrogen dioxide (NO2) and elemental carbon (EC) have been used as markers for diesel exhaust exposure. Currently EC is regarded as the best surrogate of diesel exhaust. The objective was to quantify the occupational exposure to diesel exhaust in underground tunnel construction work using a multi-metric approach, and to investigate the correlations between NO2, respirable EC, respirable organic carbon (OC), respirable total carbon (TC), respirable dust (RD), and particle number...
March 29, 2017: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/28370252/fetal-cardiac-cine-imaging-using-highly-accelerated-dynamic-mri-with-retrospective-motion-correction-and-outlier-rejection
#17
Joshua F P van Amerom, David F A Lloyd, Anthony N Price, Maria Kuklisova Murgasova, Paul Aljabar, Shaihan J Malik, Maelene Lohezic, Mary A Rutherford, Kuberan Pushparajah, Reza Razavi, Joseph V Hajnal
PURPOSE: Development of a MRI acquisition and reconstruction strategy to depict fetal cardiac anatomy in the presence of maternal and fetal motion. METHODS: The proposed strategy involves i) acquisition and reconstruction of highly accelerated dynamic MRI, followed by image-based ii) cardiac synchronization, iii) motion correction, iv) outlier rejection, and finally v) cardiac cine reconstruction. Postprocessing entirely was automated, aside from a user-defined region of interest delineating the fetal heart...
April 3, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28368660/passive-in-vehicle-driver-breath-alcohol-detection-using-advanced-sensor-signal-acquisition-and-fusion
#18
Jonas Ljungblad, Bertil Hök, Amin Allalou, Håkan Pettersson
The research objective of the present investigation is to demonstrate the present status of passive in-vehicle driver breath alcohol detection and highlighting the necessary conditions for large scale implementation of such a system. Completely passive detection has remained a challenge mainly because of the requirements on signal resolution combined with the constraints of vehicle integration. The work is part of the DADSS (driver alcohol detection system for safety) program aiming at massive deployment of alcohol sensing systems which could potentially save thousands of American lives annually...
April 3, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28367642/the-incompressibility-assumption-in-computational-simulations-of-nasal-airflow
#19
Ismael R Cal, Jose Luis Cercos-Pita, Daniel Duque
Most of the computational works on nasal airflow up to date have assumed incompressibility, given the low Mach number of these flows. However, for high temperature gradients, the incompressibility assumption could lead to a loss of accuracy, due to the temperature dependence of air density and viscosity. In this article we aim to shed some light on the influence of this assumption in a model of calm breathing in an Asian nasal cavity, by solving the fluid flow equations in compressible and incompressible formulation for different ambient air temperatures using the OpenFOAM package...
April 3, 2017: Computer Methods in Biomechanics and Biomedical Engineering
https://www.readbyqxmd.com/read/28365218/modelling-of-subarachnoid-space-width-changes-in-apnoea-resulting-as-a-function-of-blood-flow-parameters
#20
Renata Kalicka, Kamila Mazur, Jacek Wolf, Andrzej F Frydrychowski, Krzysztof Narkiewicz, Pawel J Winklewski
During apnoea, the pial artery is subjected to two opposite physiological processes: vasoconstriction due to elevated blood pressure and vasorelaxation driven by rising pH in the brain parenchyma. We hypothesized that the pial artery response to apnoea may vary, depending on which process dominate. Apnoea experiments were performed in a group of 19 healthy, non-smoking volunteers (9 men and 10 women). The following parameters were obtained for further analysis: blood pressure, the cardiac (from 0.5 to 5.0Hz) and slow (<0...
March 29, 2017: Microvascular Research
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