keyword
https://read.qxmd.com/read/38113346/dendrobium-officinale-kinura-et-migo-glycoprotein-promotes-skin-wound-healing-by-regulating-extracellular-matrix-secretion-and-fibroblast-proliferation-on-the-proliferation-phase
#21
JOURNAL ARTICLE
Jia Li, Qian Zhao, Xiaoyu Gao, Tianyi Dai, Zilin Bai, Jun Sheng, Yang Tian, Zhongbin Bai
Dendrobium officinale Kinura et Migo (DOKM) has a variety of medicinal applications; however, its ability to promote wound healing has not been previously reported. The purpose of this study is to investigate the proliferative phase of the wound healing effect of DOKM glycoprotein (DOKMG) in rats and to elucidate its mechanism of action invitro. In the present study, the ointment mixture containing DOKMG was applied to the dorsal skin wounds of the full-thickness skin excision rat model, and the results showed that the wound healing speed was faster in the proliferative phase than vaseline...
December 19, 2023: Wound Repair and Regeneration
https://read.qxmd.com/read/38111654/genome-wide-identification-and-expression-analysis-of-growth-regulating-factors-in-dendrobium-officinale-and-dendrobium-chrysotoxum
#22
JOURNAL ARTICLE
Shuying Zhu, Hongman Wang, Qiqian Xue, Huasong Zou, Wei Liu, Qingyun Xue, Xiao-Yu Ding
BACKGROUND: Dendrobium , one of the largest genera in Orchidaceae, is popular not only for its aesthetic appeal but for its significant medicinal value. Growth-regulating factors (GRFs) play an essential role in plant growth and development. However, there is still a lack of information about the evolution and biological function analysis of the GRF gene family among Dendrobium species. METHODS: Growth-regulating factors from Dendrobium officinale Kimura et Migo and Dendrobium chrysotoxum Lindl...
2023: PeerJ
https://read.qxmd.com/read/38111200/polysaccharides-from-dendrobium-officinale-improve-obesity-induced-insulin-resistance-through-the-gut-microbiota-and-the-socs3-mediated-insulin-receptor-substrate-1-signaling-pathway
#23
JOURNAL ARTICLE
Wei Jiang, Jin Tan, Jiacheng Zhang, Xin Deng, Xinyue He, Jin Zhang, Tong Liu, Rong Sun, Mengxun Sun, Kuo Chen, Tingjia Xu, Yuling Yan, Ali Moazzami, E-Jiao Wu, Jiasui Zhan, Binhong Hu
BACKGROUND: Obesity induces insulin resistance and chronic inflammation, impacting human health. The relationship between obesity, gut microbiota, and regulatory mechanisms has been extensively studied. Dendrobium officinale polysaccharide (DOP), a traditional Chinese herbal medicine, can potentially reduce insulin resistance. However, the mechanism through which DOP affects gut microbiota and alleviates obesity-induced insulin resistance in rats requires further investigation. RESULTS: The current study aimed to assess the impact of DOP on gut microbiota and insulin resistance in rats on a high-fat diet...
December 18, 2023: Journal of the Science of Food and Agriculture
https://read.qxmd.com/read/38096806/dendrobium-officinale-polysaccharides-chemical-properties-and-pharmacodynamic-effects-on-the-airways-in-experimental-conditions
#24
JOURNAL ARTICLE
Martina Šutovská, Jozef Mažerik, Michaela Kocmálová, Iveta Uhliariková, Mária Matulová, Peter Capek
The study aimed to analyze the effects of Dendrobium polysaccharides on the cough and airway reactivity and compare them with the effects of clinically used antitussives (codeine phosphate and butamirate citrate) and bronchodilators (salbutamol), using the guinea pig test system. Dendrobium officinale polysaccharides contained proteins (4.0 wt%) and phenolic compounds (1.7 wt%) with a molecular weight of 25,000 g/mol. The sugar analysis revealed a dominance of glucose (93.7 wt%) and a lesser amount of mannose (5...
December 14, 2023: Archiv der Pharmazie
https://read.qxmd.com/read/38068759/structure-health-benefits-mechanisms-and-gut-microbiota-of-dendrobium-officinale-polysaccharides-a-review
#25
REVIEW
Weijie Wu, Ziqi Zhao, Zhaoer Zhao, Dandan Zhang, Qianyi Zhang, Jiayu Zhang, Zhengyi Fang, Yiling Bai, Xiaohui Guo
Dendrobium officinale polysaccharides (DOPs) are important active polysaccharides found in Dendrobium officinale , which is commonly used as a conventional food or herbal medicine and is well known in China. DOPs can influence the composition of the gut microbiota and the degradation capacity of these symbiotic bacteria, which in turn may determine the efficacy of dietary interventions. However, the necessary analysis of the relationship between DOPs and the gut microbiota is lacking. In this review, we summarize the extraction, structure, health benefits, and related mechanisms of DOPs, construct the DOPs-host axis, and propose that DOPs are potential prebiotics, mainly composed of 1,4-β-D-mannose, 1,4-β-D-glucose, and O-acetate groups, which induce an increase in the abundance of gut microbiota such as Lactobacillus , Bifidobacterium , Akkermansia , Bacteroides , and Prevotella ...
November 23, 2023: Nutrients
https://read.qxmd.com/read/38054577/the-effect-of-dendrobium-officinale-extract-in-inhibiting-the-senescence-of-h-2-o-2-induced-fibroblasts-based-on-the-senescence-associated-secretory-phenotype
#26
JOURNAL ARTICLE
Lingyu Li, Le Zhu, Mo Chen, Ya Zhao, Haidong Jia
BACKGROUND: Dendrobium officinale is widely used for a long time in China, with effect of antioxidation, antitumor, enhancing immunity and so on. In recent years, Dendrobium officinale has been gradually used in cosmetics due to its powerful beauty effects. AIMS: Based on senescence-associated secretory phenotype (SASP), we studied the antiaging effect of Dendrobium officinale extract (DOE) on skin. METHODS: The senescent model of human skin fibroblasts was established by the induction of H2 O2 , and the content of SASP factors was tested after the treatment of DOE, such as interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1) and matrix metalloproteinase-1 (MMP-1)...
December 6, 2023: Journal of Cosmetic Dermatology
https://read.qxmd.com/read/38052727/phytochemical-profile-of-alkaloid-extract-from-dendrobium-huoshanense-and-inhibitory-effects-against-oxidative-stress-in-h2o2-induced-pc12-cells
#27
JOURNAL ARTICLE
Ailing Hui, Jingchao Chen, Shaohuan Deng, Yan Chen, Xianglin He, Li Yang, Wencheng Zhang, Zeyu Wu
This study aimed to explore the alkaloid profile of Dendrobium huoshanense and determine the potential protective effect against oxidative damage. The crude D. huoshanense alkaloid extract (DHAE) was obtained by 70% ethanol extraction and liquid-liquid partition. DHAE contained specific alkaloid components with a bundant 6-hydroxynobiline (58.15%) and trace dendrobine (3.23%) in the preliminary HPLC fingerprint and GC-MS analysis, which was distinguished from D. officinale or D. nobile. Subsequently, six alkaloids including 6-hydroxynobiline, 2-hydroxy dendrobine, nobilonine, dendrobine, Findlayines D and trans-dendrochrysanine were identified in the purified DHAE (namely DHSAE-3, DHSAE-3¢) via further solid phase extraction coupled with UPLC-MS/MS analysis...
December 5, 2023: Chemistry & Biodiversity
https://read.qxmd.com/read/38013320/research-on-the-resistance-of-isoviolanthin-to-hydrogen-peroxide-triggered-injury-of-skin-keratinocytes-based-on-transcriptome-sequencing-and-molecular-docking
#28
JOURNAL ARTICLE
Jie Wang, Hao Yin, Wei Zhu, Qingyi He, Haitang Zhang, Lu Sun, Yunxiao Qiao, Yanwei Xiang
Apoptosis of skin keratinocytes is closely associated with skin problems in humans and natural flavonoids have shown excellent biological activity. Hence, the study of flavonoids against human keratinocyte apoptosis has aroused the interest of numerous researchers. In this study, methyl thiazolyl tetrazolium (MTT) assay and Western blots were used to investigate the skin-protective effect of isoviolanthin, a di-C-glycoside derived from Dendrobium officinale, on hydrogen peroxide (H2O2)-triggered apoptosis of skin keratinocytes...
November 24, 2023: Medicine (Baltimore)
https://read.qxmd.com/read/38007572/parabacteroides-distasonis-ameliorates-insulin-resistance-via-activation-of-intestinal-gpr109a
#29
JOURNAL ARTICLE
Yonggan Sun, Qixing Nie, Shanshan Zhang, Huijun He, Sheng Zuo, Chunhua Chen, Jingrui Yang, Haihong Chen, Jielun Hu, Song Li, Jiaobo Cheng, Baojie Zhang, Zhitian Zheng, Shijie Pan, Ping Huang, Lu Lian, Shaoping Nie
Gut microbiota plays a key role in insulin resistance (IR). Here we perform a case-control study of Chinese adults (ChiCTR2200065715) and identify that Parabacteroides distasonis is inversely correlated with IR. Treatment with P. distasonis improves IR, strengthens intestinal integrity, and reduces systemic inflammation in mice. We further demonstrate that P. distasonis-derived nicotinic acid (NA) is a vital bioactive molecule that fortifies intestinal barrier function via activating intestinal G-protein-coupled receptor 109a (GPR109a), leading to ameliorating IR...
November 25, 2023: Nature Communications
https://read.qxmd.com/read/38002182/rapid-indentification-of-auramine-o-dyeing-adulteration-in-dendrobium-officinale-saffron-and-curcuma-by-sers-raman-spectroscopy-combined-with-ssa-bp-neural-networks-model
#30
JOURNAL ARTICLE
Leilei Zhang, Caihong Zhang, Wenxuan Li, Liang Li, Peng Zhang, Cheng Zhu, Yanfei Ding, Hongwei Sun
(1) Background: Rapid and accurate determination of the content of the chemical dye Auramine O(AO) in traditional Chinese medicines (TCMs) is critical for controlling the quality of TCMs. (2) Methods: Firstly, various models were developed to detect AO content in Dendrobium officinale ( D. officinale ). Then, the detection of AO content in Saffron and Curcuma using the D. officinale training set as a calibration model. Finally, Saffron and Curcuma samples were added to the training set of D. officinale to predict the AO content in Saffron and Curcuma using secondary wavelength screening...
November 14, 2023: Foods (Basel, Switzerland)
https://read.qxmd.com/read/38001848/plant-wide-target-metabolomics-provides-a-novel-interpretation-of-the-changes-in-chemical-components-during-dendrobium-officinale-traditional-processing
#31
JOURNAL ARTICLE
Pengfei Liu, Bei Fan, Yuwen Mu, Litao Tong, Cong Lu, Long Li, Jiameng Liu, Jing Sun, Fengzhong Wang
The traditional processing of Dendrobium officinale (DO) is performed in five necessary processing steps: processing fresh strips, drying at 85 °C, curling, molding, and drying at 35 °C (Fengdou). The antioxidant activity of DO is increased after it is processed into Fengdou. To comprehensively analyze the changes in the functional components, a plant-wide target metabolomics approach was employed. In total, 739 differential chemical components were identified in five processing treatments, mainly highlighting differences in the levels of phenolic acids, flavonoids, lipids, and amino acids and their derivatives, and the glycosylation of aglycone resulted in the upregulation of flavonoid glycoside levels...
November 12, 2023: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/38001764/comparative-evaluation-of-the-physiochemical-properties-and-antioxidant-and-hypoglycemic-activities-of-dendrobium-officinale-leaves-processed-using-different-drying-techniques
#32
JOURNAL ARTICLE
Gonglin Cai, Hangmeng Dong, Shoulong Liu, Weijie Wu, Hailong Yang
Dendrobium officinale leaves have the potential to be processed into natural antioxidants, functional foods, and food additives. To maximally maintain their quality, fresh D. officinale leaves were dehydrated using different drying methods, i.e., hot air drying (HD), microwave drying (MD), infrared drying (IRD), and freeze drying (FD), and then the physicochemical properties, microstructure, and biological activities of the dried samples were compared. The results showed that, with the FD method, the samples had a porous microstructure, maintained the highest phenolic content, and demonstrated the highest antioxidant and hypoglycemic activities...
October 26, 2023: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/37981116/role-of-gut-microbiota-on-regulation-potential-of-dendrobium-officinale-kimura-migo-in-metabolic-syndrome-in-vitro-fermentation-screening-and-in-vivo-verification-in-db-db-mice
#33
JOURNAL ARTICLE
Qianbo Song, Sau Wan Cheng, Junju Zou, Kendra Sek Lam Li, Huiyuan Cheng, David Tai Wai Lau, Quanbin Han, Xiao Yang, Pang Chui Shaw, Zhong Zuo
ETHNOPHARMACOLOGICAL RELEVANCE: Dendrobium officinale Kimura & Migo (DEN) is a traditional medicine in China since Han dynasty. Decoction of its stem is often used in the treatment of Type-II diabetes (T2D), which is a typical metabolic disease accompanied with the impaired metabolic function of blood glucose and lipid. AIM OF THE STUDY: Our study aimed to investigate the role of gut microbiota in differentiating DEN from different sources and its related pathway in the alleviation of metabolic syndromes induced by T2D...
November 17, 2023: Journal of Ethnopharmacology
https://read.qxmd.com/read/37945232/natural-product-osthole-can-significantly-disrupt-cell-wall-integrity-and-dynamic-balance-of-fusarium-oxysporum
#34
JOURNAL ARTICLE
Ke Hu, Rongyu Li, Feixu Mo, Yi Ding, Aiai Zhou, Xue Guo, Ruotong Li, Min Li, Minggui Ou, Ming Li
Dendrobium officinale Kimura et Migo is a traditional Chinese herbal medicinal plant. However, the frequent occurrence of soft rot disease (SRD) is one of the most harmful diseases in D. officinale production in recent years, which can seriously affect its yield and quality. In this study, the major pathogenic fungus (SR-1) was isolated from D. officinale with typical symptoms of SRD, and was identified as Fusarium oxysporum through morphological and molecular identification. The biological activities of five natural products were determined against F...
November 2023: Pesticide Biochemistry and Physiology
https://read.qxmd.com/read/37933979/dendrocandin-u-from-dendrobium-officinale-kimura-et-migo-inhibits-m1-polarization-in-alveolar-macrophage-by-suppressing-nf-%C3%AE%C2%BAb-signaling-pathway
#35
JOURNAL ARTICLE
Xian-Mei Piao, Ming-Feng Feng, Wei-Ping Zhao, Zhi-Hang Wu, Wen-Wen Zhang, Hui-Min Hou, Jin-Hui Wang, Li-Bo Wang, Jian Huang, Yan Zhang
Dendrobium officinale Kimura et Migo is a valuable and homologous medicine and food traditional Chinese medicine. Currently there are few studies on the anti-inflammatory activity of lipophilic components. The aim of this study was to explore the anti-inflammatory effect and mechanism of the lipophilic compounds in Dendrobium officinale. Six compounds were isolated and identified, including three bibenzyl compounds, dendrocandin U, dendronbibisline B, erianin, and three lignans, (-)-syringaresinol, (+)-syringaresinol-O-β-D-glucopyranoside, 5-methoxy-(+)-isolariciresinol...
November 7, 2023: Chemistry & Biodiversity
https://read.qxmd.com/read/37896088/genome-wide-identification-and-characterization-of-the-nac-gene-family-and-its-involvement-in-cold-response-in-dendrobium-officinale
#36
JOURNAL ARTICLE
Qianyu Yang, Zhihui Li, Xiao Wang, Chunqian Jiang, Feihong Liu, Yuxin Nian, Xiaoyun Fu, Guangzhu Zhou, Lei Liu, Hui Wang
The NAC (NAM, ATAF1/2 and CUC2) gene family is one of the largest plant-specific transcription factor families, functioning as crucial regulators in diverse biological processes such as plant growth and development as well as biotic and abiotic stress responses. Although it has been widely characterized in many plants, the significance of the NAC family in Dendrobium officinale remained elusive up to now. In this study, a genome-wide search method was conducted to identify NAC genes in Dendrobium officinale (DoNACs) and a total of 110 putative DoNACs were obtained...
October 20, 2023: Plants (Basel, Switzerland)
https://read.qxmd.com/read/37895055/1-5-6-trimethoxy-2-7-dihydroxyphenanthrene-from-dendrobium-officinale-exhibited-antitumor-activities-for-hela-cells
#37
JOURNAL ARTICLE
Chong Liang, Chonglun Zhang, Yinlin Zhuo, Baocheng Gong, Weizhuo Xu, Guogang Zhang
Natural products are irreplaceable reservoirs for cancer treatments. In this study, 12 phenanthrene compounds were extracted and isolated from Dendrobium officinale . Each chemical structure was identified using comprehensive NMR analysis. All compounds were evaluated for their cytotoxic activities against five tumor cell lines, i.e., HeLa, MCF-7, SK-N-AS, Capan-2 and Hep G2. Compound 5, 1,5,6-trimethoxy-2,7-dihydroxyphenanthrene, displayed the most significant cytotoxic effect against HeLa and Hep G2 cells, with an IC50 of 0...
October 19, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37894541/-dendrobium-officinale-polysaccharide-converts-m2-into-m1-subtype-macrophage-polarization-via-the-stat6-ppar-r-and-jagged1-notch1-signaling-pathways-to-inhibit-gastric-cancer
#38
JOURNAL ARTICLE
Yi Zhao, Xuefeng Lu, Hongxia Huang, Yao Yao, Hongning Liu, Youzhi Sun
Dendrobium officinale polysaccharide (DOP) has shown various biological activities. However, the ability of DOP to participate in immune regulation during anti-gastric cancer treatment has remained unclear. In this study, the in vitro results showed that DOP has the potential to polarize THP-1 macrophages from the M2 to the M1 phenotype, downregulate the STAT6/PPAR-r signaling pathway and the protein expression of their down-targeted ARG1 and TGM2, and further decrease the main protein and mRNA expression in the JAGGED1/NOTCH1 signaling pathway...
October 12, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/37883687/phenolics-from-dendrobium-officinale-leaf-ameliorate-dextran-sulfate-sodium-induced-chronic-colitis-by-regulating-gut-microbiota-and-intestinal-barrier
#39
JOURNAL ARTICLE
Peiyi Wang, Ming Cai, Kai Yang, Peilong Sun, Jing Xu, Zhenhao Li, Baoming Tian
The increasing incidence of colitis and the side effects of its therapeutic drugs have led to the search for compounds of natural origin, including phenolics, as new treatments for colitis. In this study, the potential mechanism of Dendrobium officinale leaf phenolics (DOP) on the relief of dextran sulfate sodium (DSS)-induced colitis was explored. The results showed that DOP treatment for 36 days reduced the symptoms of colitis caused by DSS, including reduction of the disease activity index and alleviation of colonic tissue damage...
October 26, 2023: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/37877149/exploring-the-action-mechanism-and-validation-of-the-key-pathways-of-dendrobium-officinale-throat-clearing-formula-for-the-treatment-of-chronic-pharyngitis-based-on-network-pharmacology
#40
JOURNAL ARTICLE
Xi Fang, Xiao-Feng Jiang, Yi-Piao Zhang, Cheng-Liang Zhou, Ying-Jie Dong, Bo Li, Gui-Yuan Lv, Su-Hong Chen
This study investigated the molecular action mechanism of a compound herb, also known as the Dendrobium officinale throat-clearing formula (QYF), by using network pharmacology and animal experimental validation methods to treat chronic pharyngitis (CP). The active ingredients and disease targets of QYF were determined by searching the Batman-TCM and GeneCards databases. Subsequently, the drug-active ingredient-target and protein-protein interaction networks were constructed, and the core targets were obtained through network topology...
October 18, 2023: Combinatorial Chemistry & High Throughput Screening
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