keyword
https://read.qxmd.com/read/38377609/roaming-dogs-intense-brown-dog-tick-infestation-and-emerging-rocky-mountain-spotted-fever-in-tijuana-m%C3%A3-xico
#21
JOURNAL ARTICLE
Janet Foley, Andrés M López-Pérez, Francesca Rubino, Laura Backus, Cusi Ferradas, Julio Barrón-Rodriguez, Hugo Mendoza, Rodolfo Arroyo-Machado, Leslie C Inustroza-Sánchez, Oscar E Zazueta
A two decades-long epidemic of Rocky Mountain spotted fever in northern México reached the U.S. border city of Tijuana in 2021. Cases were near the city periphery in marginalized areas, some lacking infrastructure such as streets or utilities. We worked in the three census areas where human cases were reported and in 12 additional control Áreas Geoestadisticas Básicas. There were dogs, the primary tick host and Rickettsia rickettsii reservoir, in 76% of homes, with 2.2 owned dogs per home on average, approximately equal numbers of roaming dogs were seen, and 46...
February 20, 2024: American Journal of Tropical Medicine and Hygiene
https://read.qxmd.com/read/38376944/immunotherapy-resistant-acute-lymphoblastic-leukemia-cells-exhibit-reduced-cd19-and-cd22-expression-and-btk-pathway-dependency
#22
JOURNAL ARTICLE
Sarah Aminov, Orsi Giricz, David T Melnekoff, R Alejandro Sica, Veronika Polishchuk, Cristian Papazoglu, Bonnie Yates, Hao-Wei Wang, Srabani Sahu, Yanhua Wang, Shanisha Gordon-Mitchell, Violetta V Leshchenko, Carolina Schinke, Kith Pradhan, Srinivas Aluri, Moah Sohn, Stefan K Barta, Beamon Agarwal, Mendel Goldfinger, Ioannis Mantzaris, Aditi Shastri, William Matsui, Ulrich Steidl, Joshua D Brody, Nirali N Shah, Samir Parekh, Amit Verma
While therapies targeting CD19 by antibodies, CAR-T cells and T cell engagers have improved the response rates in B-cell malignancies; the emergence of resistant cell populations with low CD19 expression can lead to relapsed disease. We developed an in vitro model of adaptive resistance facilitated by chronic exposure of leukemia cells to a CD19-immunotoxin. Single-cell (sc) RNAseq showed increase in transcriptionally distinct CD19low populations in resistant cells. Mass cytometry demonstrated that CD22 was also decreased in these CD19low resistant cells...
February 20, 2024: Journal of Clinical Investigation
https://read.qxmd.com/read/38374643/computer-vision-and-machine-learning-techniques-for-automatic-3d-virtual-images-overlapping-during-augmented-reality-guided-robotic-partial-nephrectomy
#23
JOURNAL ARTICLE
Daniele Amparore, Michele Sica, Paolo Verri, Federico Piramide, Enrico Checcucci, Sabrina De Cillis, Alberto Piana, Davide Campobasso, Mariano Burgio, Edoardo Cisero, Giovanni Busacca, Michele Di Dio, Pietro Piazzolla, Cristian Fiori, Francesco Porpiglia
OBJECTIVES: The research's purpose is to develop a software that automatically integrates and overlay 3D virtual models of kidneys harboring renal masses into the Da Vinci robotic console, assisting surgeon during the intervention. INTRODUCTION: Precision medicine, especially in the field of minimally-invasive partial nephrectomy, aims to use 3D virtual models as a guidance for augmented reality robotic procedures. However, the co-registration process of the virtual images over the real operative field is performed manually...
2024: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/38339670/temperature-corrected-calibration-of-gs3-and-teros-12-soil-water-content-sensors
#24
JOURNAL ARTICLE
Paolo Nasta, Francesca Coccia, Ugo Lazzaro, Heye R Bogena, Johan A Huisman, Benedetto Sica, Caterina Mazzitelli, Harry Vereecken, Nunzio Romano
The continuous monitoring of soil water content is commonly carried out using low-frequency capacitance sensors that require a site-specific calibration to relate sensor readings to apparent dielectric bulk permittivity ( Kb ) and soil water content ( θ ). In fine-textured soils, the conversion of Kb to θ is still challenging due to temperature effects on the bound water fraction associated with clay mineral surfaces, which is disregarded in factory calibrations. Here, a multi-point calibration approach accounts for temperature effects on two soils with medium to high clay content...
February 1, 2024: Sensors
https://read.qxmd.com/read/38337490/the-unveiled-triad-clinical-radiological-and-pathological-insights-into-hypersensitivity-pneumonitis
#25
REVIEW
Gaetano Rea, Marialuisa Bocchino, Roberta Lieto, Roberta Eufrasia Ledda, Michele D'Alto, Marco Sperandeo, Raffaella Lucci, Patrizio Pasquinelli, Stefano Sanduzzi Zamparelli, Giorgio Bocchini, Tullio Valente, Giacomo Sica
Hypersensitivity pneumonitis (HP) is a diffuse parenchymal lung disease (DLPD) characterized by complex interstitial lung damage with polymorphic and protean inflammatory aspects affecting lung tissue targets including small airways, the interstitium, alveolar compartments and vascular structures. HP shares clinical and often radiological features with other lung diseases in acute or chronic forms. In its natural temporal evolution, if specific therapy is not initiated promptly, HP leads to progressive fibrotic damage with reduced lung volumes and impaired gas exchange...
January 30, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38337396/neuromuscular-electrical-stimulation-does-not-influence-spinal-excitability-in-multiple-sclerosis-patients
#26
JOURNAL ARTICLE
Martina Scalia, Riccardo Borzuola, Martina Parrella, Giovanna Borriello, Francesco Sica, Fabrizia Monteleone, Elisabetta Maida, Andrea Macaluso
(1) Background : Neuromuscular electrical stimulation (NMES) has beneficial effects on physical functions in Multiple sclerosis (MS) patients. However, the neurophysiological mechanisms underlying these functional improvements are still unclear. This study aims at comparing acute responses in spinal excitability, as measured by soleus Hoffmann reflex (H-reflex), between MS patients and healthy individuals, under three experimental conditions involving the ankle planta flexor muscles: (1) passive NMES (pNMES); (2) NMES superimposed onto isometric voluntary contraction (NMES+); and (3) isometric voluntary contraction (ISO)...
January 25, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38324723/haploidentical-bone-marrow-transplantation-for-aml-in-remission-following-tbf-conditioning-a-long-term-follow-up
#27
JOURNAL ARTICLE
Anna Maria Raiola, Carmen Di Grazia, Alida Dominietto, Stefania Bregante, Sabrina Giammarco, Riccardo Varaldo, Federica Sorà, Elisabetta Metafuni, Maria Assunta Limongiello, Antonella Laudisi, Monica Passannante, Eugenio Galli, Massimiliano Gambella, Simona Sica, Andrea Bacigalupo, Emanuele Angelucci, Patrizia Chiusolo
No abstract text is available yet for this article.
February 7, 2024: Blood Advances
https://read.qxmd.com/read/38317956/tailoring-the-stress-response-of-human-skin-cells-by-substantially-limiting-the-nuclear-localization-of-angiogenin
#28
JOURNAL ARTICLE
Rosanna Culurciello, Ilaria Di Nardo, Andrea Bosso, Francesca Tortora, Romualdo Troisi, Filomena Sica, Angela Arciello, Eugenio Notomista, Elio Pizzo
Human angiogenin (hANG) is the most studied stress-induced ribonuclease (RNase). In physiological conditions it performs its main functions in nucleoli, promoting cell proliferation by rDNA transcription, whereas it is strongly limited by its inhibitor (RNH1) throughout the rest of the cell. In stressed cells hANG dissociates from RNH1 and thickens in the cytoplasm where it manages the translational arrest and the recruitment of stress granules, thanks to its propensity to cleave tRNAs and to induce the release of active halves...
February 15, 2024: Heliyon
https://read.qxmd.com/read/38293188/automating-the-human-connectome-project-s-temporal-ica-pipeline
#29
Chunhui Yang, Timothy S Coalson, Stephen M Smith, Jennifer S Elam, David C Van Essen, Matthew F Glasser
Functional magnetic resonance imaging (fMRI) data are dominated by noise and artifacts, with only a small fraction of the variance relating to neural activity. Temporal independent component analysis (tICA) is a recently developed method that enables selective denoising of fMRI artifacts related to physiology such as respiration. However, an automated and easy to use pipeline for tICA has not previously been available; instead, two manual steps have been necessary: 1) setting the group spatial ICA dimensionality after MELODIC's Incremental Group-PCA (MIGP) and 2) labeling tICA components as artifacts versus signals...
January 16, 2024: bioRxiv
https://read.qxmd.com/read/38270175/on-the-mechanism-of-action-of-arsenoplatins-arsenoplatin-1-binding-to-a-b-dna-dodecamer
#30
JOURNAL ARTICLE
Romualdo Troisi, Gabriella Tito, Giarita Ferraro, Filomena Sica, Lara Massai, Andrea Geri, Damiano Cirri, Luigi Messori, Antonello Merlino
The reaction of Pt-based anticancer agents with arsenic trioxide affords robust complexes known as arsenoplatins. The prototype of this family of anticancer compounds is arsenoplatin-1 (AP-1) that contains an As(OH)2 fragment linked to a Pt(II) moiety derived from cisplatin. Crystallographic and spectrometric studies of AP-1 binding to a B-DNA double helix dodecamer are presented here, in comparison with cisplatin and transplatin. Results reveal that AP-1, cisplatin and transplatin react differently with the DNA model system...
January 25, 2024: Dalton Transactions: An International Journal of Inorganic Chemistry
https://read.qxmd.com/read/38257785/risk-factors-associated-with-opportunistic-infections-among-people-living-with-hiv-aids-and-receiving-an-antiretroviral-therapy-in-gabon-central-africa
#31
JOURNAL ARTICLE
Augustin Mouinga-Ondeme, Neil Michel Longo-Pendy, Ivan Cyr Moussadji Kinga, Barthélémy Ngoubangoye, Pamela Moussavou-Boundzanga, Larson Boundenga, Abdoulaye Diane, Jeanne Sica, Ivan Sosthene Mfouo-Tynga, Edgard Brice Ngoungou
The Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (HIV/AIDS) is still one of the main causes of death in sub-Saharan Africa. Antiretroviral therapies (ARTs) have significantly improved the health conditions of people living with HIV/AIDS (PLWHA). Consequently, a significant drop in morbidity and mortality, along with a reduced incidence of opportunistic infections (OIs), has been observed. However, certain atypical and biological profiles emerge in ART patients post-examination. The objective of this study was to identify the risk factors that contributed to the onset of OIs in HIV patients undergoing ART in Gabon...
January 4, 2024: Viruses
https://read.qxmd.com/read/38256682/scientific-status-quo-of-small-renal-lesions-diagnostic-assessment-and-radiomics
#32
REVIEW
Piero Trovato, Igino Simonetti, Alessio Morrone, Roberta Fusco, Sergio Venanzio Setola, Giuliana Giacobbe, Maria Chiara Brunese, Annarita Pecchi, Sonia Triggiani, Giuseppe Pellegrino, Giuseppe Petralia, Giacomo Sica, Antonella Petrillo, Vincenza Granata
Background: Small renal masses (SRMs) are defined as contrast-enhanced renal lesions less than or equal to 4 cm in maximal diameter, which can be compatible with stage T1a renal cell carcinomas (RCCs). Currently, 50-61% of all renal tumors are found incidentally. Methods : The characteristics of the lesion influence the choice of the type of management, which include several methods SRM of management, including nephrectomy, partial nephrectomy, ablation, observation, and also stereotactic body radiotherapy...
January 18, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38252762/optimal-medical-management-of-atherosclerotic-intracranial-stenosis
#33
REVIEW
Ashley M Wabnitz, Tanya N Turan
Reducing the high risk of recurrent stroke in patients with symptomatic intracranial atherosclerotic stenosis (sICAS) has proven to be challenging, but aggressive medical management, with intensive risk factor control and antithrombotic therapy, has been shown to be beneficial. High-intensity statins are recommended for patients with atherosclerotic stroke, including sICAS. Ezetimibe and PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitors are beneficial for those who fail to reach low-density lipoprotein targets or those with statin intolerance...
February 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38243667/edge-type-hyperintense-intracranial-artery-plaque-a-potential-mri-biomarker-of-stroke-recurrence
#34
JOURNAL ARTICLE
Hongxia Li, Sui Chen, Jia Liu, Yingle Li, Changsheng Zhou, Bangjun Guo, Chunxiang Tang, Quanhui Liu, Beibei Zhi, Longjiang Zhang, Zhiqiang Zhang, Xiaoqing Cheng, Guangming Lu
BACKGROUND: Identifying patients at high risk of stroke recurrence is important for stroke prevention and treatment. PURPOSE: To explore the characteristics of T1 hyperintense plaques (HIP) and their relationship with stroke recurrence in patients with symptomatic intracranial atherosclerotic stenosis (sICAS). STUDY TYPE: Retrospective. POPULATION: One hundred fifty-seven patients with moderate-to-severe (≥50%) nonocclusive sICAS and MRI studies (42 females and 115 males, mean age 58...
January 19, 2024: Journal of Magnetic Resonance Imaging: JMRI
https://read.qxmd.com/read/38223477/car-t-cell-therapy-in-b-cell-acute-lymphoblastic-leukemia
#35
REVIEW
Ugo Testa, Simona Sica, Elvira Pelosi, Germana Castelli, Giuseppe Leone
Treatment of refractory and relapsed (R/R) B acute lymphoblastic leukemia (B-ALL) is an unmet medical need in both children and adults. Studies carried out in the last two decades have shown that autologous T cells engineered to express a chimeric antigen receptor (CAR-T) represent an effective technique for treating these patients. Antigens expressed on B-cells, such as CD19, CD20, and CD22, represent targets suitable for treating patients with R/R B-ALL. CD19 CAR-T cells induce a high rate (80-90%) of complete remissions in both pediatric and adult R/R B-ALL patients...
2024: Mediterranean Journal of Hematology and Infectious Diseases
https://read.qxmd.com/read/38221229/taxonomic-revision-of-orcevia-thorell-1890-with-description-of-fifteen-new-species-araneae-salticidae-euophryini
#36
JOURNAL ARTICLE
Kun Yu, Wayne P Maddison, Junxia Zhang
The Asian euophryine genus Orcevia Thorell, 1890 is revised, and fifteen new species from southern China and Southeast Asia are described: Orcevia bokoblin Yu, Maddison & Zhang, sp. nov. (), O. calcicola Yu, Maddison & Zhang, sp. nov. (), O. deelemanae Yu & Zhang, sp. nov. (), O. feitongae Yu & Zhang, sp. nov. (), O. gongae Yu & Zhang, sp. nov. (), O. jinping Yu & Zhang, sp. nov. (), O. meinei Yu, Maddison & Zhang, sp. nov. (), O. mercuryi Yu, Maddison & Zhang, sp. nov. (), O...
December 14, 2023: Zootaxa
https://read.qxmd.com/read/38219311/ordered-hierarchical-superlattice-amplifies-coated-ceo-2-nanoparticles-luminescence
#37
JOURNAL ARTICLE
Noemi Gallucci, Marie-Sousai Appavou, Nathan Cowieson, Gerardino D'Errico, Rocco Di Girolamo, Stefano Lettieri, Filomena Sica, Giuseppe Vitiello, Luigi Paduano
Achieving a controlled preparation of nanoparticle superstructures with spatially periodic arrangement, also called superlattices, is one of the most intriguing and open questions in soft matter science. The interest in such regular superlattices originates from the potentialities in tailoring the physicochemical properties of the individual constituent nanoparticles, eventually leading to emerging behaviors and/or functionalities that are not exhibited by the initial building blocks. Despite progress, it is currently difficult to obtain such ordered structures; the influence of parameters, such as size, softness, interaction potentials, and entropy, are neither fully understood yet and not sufficiently studied for 3D systems...
January 9, 2024: Journal of Colloid and Interface Science
https://read.qxmd.com/read/38207152/-not-available
#38
JOURNAL ARTICLE
Ana Yibby Forero, Gina Emely Morales, Luis Carlos Forero
Introducción. La inactividad física y los comportamientos sedentarios demostraron ser factores de riesgo en la prevalencia de enfermedades como la obesidad. Objetivo. Analizar la relación entre la actividad física, el sedentarismo y el estado nutricional en la población de 18 a 64 años en Colombia, 2015. Materiales y métodos. Se llevó a cabo el análisis secundario de la encuesta de nutrición de Colombia en 2015, utilizando variables sociodemográficas (edad, sexo, etnia, área geográfica, región e índice de riqueza) y, además, peso, talla, actividad física y sedentarismo...
December 29, 2023: Biomédica: Revista del Instituto Nacional de Salud
https://read.qxmd.com/read/38202233/artificial-intelligence-and-radiomics-for-endometrial-cancer-mri-exploring-the-whats-whys-and-hows
#39
REVIEW
Elisabetta Leo, Arnaldo Stanzione, Mariaelena Miele, Renato Cuocolo, Giacomo Sica, Mariano Scaglione, Luigi Camera, Simone Maurea, Pier Paolo Mainenti
Endometrial cancer (EC) is intricately linked to obesity and diabetes, which are widespread risk factors. Medical imaging, especially magnetic resonance imaging (MRI), plays a major role in EC assessment, particularly for disease staging. However, the diagnostic performance of MRI exhibits variability in the detection of clinically relevant prognostic factors (e.g., deep myometrial invasion and metastatic lymph nodes assessment). To address these challenges and enhance the value of MRI, radiomics and artificial intelligence (AI) algorithms emerge as promising tools with a potential to impact EC risk assessment, treatment planning, and prognosis prediction...
December 30, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/38202097/robotic-lateral-pelvic-lymph-node-dissection-in-rectal-cancer-a-feasibility-study-from-a-european-centre
#40
JOURNAL ARTICLE
Tou Pin Chang, Oroog Ali, Kostas Tsimogiannis, Giuseppe S Sica, Jim S Khan
INTRODUCTION: The role of robotic lateral pelvic lymph node dissection (LPLND) for lateral pelvic nodal disease (LPND) in rectal cancer has yet to be investigated in the Western hemisphere. This study aims to investigate the safety and feasibility of robotic LPLND by utilising a well-established totally robotic TME protocol. METHODS: We conducted a retrospective study on 17 consecutive patients who underwent robotic LPLND for LPND ± TME for rectal cancer between 2015 and 2021...
December 23, 2023: Journal of Clinical Medicine
keyword
keyword
30236
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.