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https://www.readbyqxmd.com/read/28803019/daily-lying-behavior-of-lactating-holstein-cows-during-an-estrus-synchronization-protocol-and-its-associations-with-fertility
#1
B F Silper, A M L Madureira, L B Polsky, S Soriano, A F Sica, J L M Vasconcelos, R L A Cerri
Objectives were to quantify lying behavior (LB) during an estradiol and progesterone-based synchronization protocol, to assess risk factors for ovulation, pregnancy per AI (P/AI), and degree of behavioral change at estrus, and to investigate the associations between estrus LB and walking activity. Holstein cows (43.6 ± 11.0 kg of milk/d) were fitted with leg-mounted accelerometers. Total lying time/d (L_time), bout frequency (bout_N), average lying bout duration, and relative increase in walking activity (ACT%) were evaluated for 1,411 timed artificial insemination events...
August 9, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28803016/association-between-ambient-temperature-and-humidity-vaginal-temperature-and-automatic-activity-monitoring-on-induced-estrus-in-lactating-cows
#2
Liam B Polsky, Augusto M L Madureira, Eraldo L Drago Filho, Sergio Soriano, Alex F Sica, José L M Vasconcelos, Ronaldo L A Cerri
The objective of this study was to determine the association between ambient temperature and humidity, vaginal temperature, and automated activity monitoring in synchronized cows. Lactating Holstein cows (n = 641; 41.5 ± 9.4 kg of milk/d) were fitted with leg-mounted pedometers, resulting in 843 evaluated activity episodes of estrus. Vaginal temperature was monitored using thermometers attached to an intravaginal device as part of a timed artificial insemination (TAI) protocol; vaginal temperature was recorded every 10 min for 3 d...
August 9, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28796281/changes-in-protein-serum-levels-during-stem-cell-transplantation
#3
Elisabetta Metafuni, Sabrina Giammarco, Daniela Giovanna De Ritis, Monica Rossi, Francesco Corrente, Nicola Piccirillo, Andrea Paolo Bacigalupo, Simona Sica, Patrizia Chiusolo
BACKGROUND: GvHD is one of the major complication after stem cell transplantation affecting transplant-related mortality. Throughout the last years, many serum proteins were been proposed as possible biomarkers for GvHD. AIMS: We studied the trend of five of the most studied serum proteins to evaluate if a correlation exists between proteins concentration and post-HSCT outcomes. MATERIALS AND METHODS: We measured serum concentration of REG3α, ST2, BAFF, CXCL9 and elafin in a cohort of 77 patients submitted to HSCT in our department...
August 10, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28795035/aortopulmonary-fistula-presenting-without-an-endoleak-after-thoracic-endovascular-aortic-repair
#4
Giacomo Sica, Gaetano Rea, Giorgio Bocchini, Romilda Lombardi, Massimo Muto, Tullio Valente
Herein, we report the case of a 60-year-old man, a smoker with a history of arterial hypertension and diabetes mellitus. After computed tomography (CT) for an episode of hemoptysis, the patient underwent elective thoracic endovascular aortic repair (TEVAR) because of a degenerative aneurysm of the descending thoracic aorta. The area of perianeurysmal pulmonary atelectasis reported on the CT scan was not considered. Three months later, he developed an aortopulmonary fistula without endoleaks. Although TEVAR is a relatively safe procedure, no detail should be overlooked in the preoperative evaluation in order to avoid life-threatening complications...
August 2017: Korean Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28777706/mental-and-physical-wellbeing-in-oncology-haematology-unit-personnel
#5
Nicola Magnavita, Cristina Sestili, Alice Mannocci, Elisa Ercoli, Antonia Boccia, Gloria Bonaga, Simona Sica, Massimo Maurici, Rosaria Alvaro, Alessandro Sili, Claudio Cartoni, Giuseppe La Torre
BACKGROUND: HCWs in UHUs face high job demand that can have adverse health effects. OBJECTIVE: Investigate relationship between some job stressors and health-related quality of life among HCWs of three UHUs in Rome. METHODS: Cross-sectional study. Work-related stress was measured with Demand-Control Questionnaire; health-related functioning with MCS and PCS of SF-12 Survey; positivity with Positivity Scale. RESULTS: Data of 201 respondents were analyzed...
August 4, 2017: Archives of Environmental & Occupational Health
https://www.readbyqxmd.com/read/28772192/in-situ-mass-spectrometry-monitoring-of-fungal-cultures-led-to-the-identification-of-four-peptaibols-with-a-rare-threonine-residue
#6
Vincent P Sica, Evan R Rees, Huzefa A Raja, José Rivera-Chávez, Joanna E Burdette, Cedric J Pearce, Nicholas H Oberlies
Peptaibols are an intriguing class of fungal metabolites due both to their wide range of reported bioactivities and to the structural variability that can be generated by the exchange of variable amino acid building blocks. In an effort to streamline the discovery of structurally diverse peptaibols, a mass spectrometry surface sampling technique was applied to screen the chemistry of fungal cultures in situ. Four previously undescribed peptaibols, all containing a rare threonine residue, were identified from a fungal culture (MSX53554), which was identified as Nectriopsis Maire (Bionectriaceae, Hypocreales, Ascomycota)...
July 31, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28747392/evaluation-of-grading-systems-in-stage-i-lung-adenocarcinomas-a-retrospective-cohort-study
#7
Tamás Zombori, József Furák, Tibor Nyári, Gábor Cserni, László Tiszlavicz
AIMS: There is no internationally accepted grading system for lung adenocarcinoma despite the new WHO classification. The architectural grade, the Kadota grade and the Sica score were evaluated and compared with overall (OS) and disease-free survival (DFS). METHODS: Comprehensive histological subtyping was used in a series of resected stage I lung adenocarcinoma to identify subtypes of adenocarcinomas, the architectural grade, the Kadota grade, the Sica grade, the mitotic count, nuclear atypia, the presence of lymphovascular, vascular and airway propagation, necrosis, and micropapillary or solid growth pattern in any percentage...
July 26, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28728794/myeloid-suppressor-cells-in-cancer-and-autoimmunity
#8
REVIEW
Antonio Sica, Marco Massarotti
A bottleneck for immunotherapy of cancer is the immunosuppressive microenvironment in which the tumor cells proliferate. Cancers harness the immune regulatory mechanism that prevents autoimmunity from evading immunosurveillance and promoting immune destruction. Regulatory T cells, myeloid suppressor cells, inhibitory cytokines and immune checkpoint receptors are the major components of the immune system acting in concert with cancer cells and causing the subversion of anti-tumor immunity. This redundant immunosuppressive network poses an impediment to efficacious immunotherapy by facilitating tumor progression...
July 17, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/28728086/nanostructured-lipid-systems-modified-with-waste-material-of-propolis-for-wound-healing-design-in-vitro-and-in-vivo-evaluation
#9
Hélen Cássia Rosseto, Lucas de Alcântara Sica de Toledo, Lizziane Maria Belloto de Francisco, Elisabetta Esposito, Yunsook Lim, Giuseppe Valacchi, Rita Cortesi, Marcos Luciano Bruschi
Propolis, a natural compound that can accelerate the wound healing process, is mainly used as ethanolic extract. The extractive solution may also be obtained from the propolis by-product (BP), transforming this waste material into a pharmaceutical active ingredient. Even if propolis does not show toxicity, when used as an extract over harmed skin or mucosa, the present ethanol content may be harmful to the tissue recovering, besides hindering the drug release. This study describes the development of solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) as topical propolis delivery systems and the investigation of their in vitro and in vivo activities...
July 10, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28712361/plasmodium-knowlesi-a-superb-in-vivo-nonhuman-primate-model-of-antigenic-variation-in-malaria
#10
M R Galinski, S A Lapp, M S Peterson, F Ay, C J Joyner, K G LE Roch, L L Fonseca, E O Voit
Antigenic variation in malaria was discovered in Plasmodium knowlesi studies involving longitudinal infections of rhesus macaques (M. mulatta). The variant proteins, known as the P. knowlesi Schizont Infected Cell Agglutination (SICA) antigens and the P. falciparum Erythrocyte Membrane Protein 1 (PfEMP1) antigens, expressed by the SICAvar and var multigene families, respectively, have been studied for over 30 years. Expression of the SICA antigens in P. knowlesi requires a splenic component, and specific antibodies are necessary for variant antigen switch events in vivo...
July 17, 2017: Parasitology
https://www.readbyqxmd.com/read/28706153/inhibitor-of-growth-protein-4-interacts-with-beclin-1-and-represses-autophagy
#11
Valentina Sica, José Manuel Bravo-San Pedro, Guo Chen, Guillermo Mariño, Sylvie Lachkar, Valentina Izzo, Maria Chiara Maiuri, Mireia Niso-Santano, Guido Kroemer
Beclin 1 (BECN1) is a multifunctional protein that activates the pro-autophagic class III phosphatidylinositol 3-kinase (PIK3C3, best known as VPS34), yet also interacts with multiple negative regulators. Here we report that BECN1 interacts with inhibitor of growth family member 4 (ING4), a tumor suppressor protein that is best known for its capacity to interact with the tumor suppressor protein p53 (TP53) and the acetyltransferase E1A binding protein p300 (EP300). Removal of TP53 or EP300 did not affect the BECN1/ING4 interaction, which however was lost upon culture of cells in autophagy-inducing, nutrient free conditions...
July 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28699973/healthy-school-happy-school-design-and-protocol-for-a-randomized-clinical-trial-designed-to-prevent-weight-gain-in-children
#12
Daniela Schneid Schuh, Maíra Ribas Goulart, Sandra Mari Barbiero, Caroline D'Azevedo Sica, Raphael Borges, David William Moraes, Lucia Campos Pellanda
Background: Schools have become a key figure for the promotion of health and obesity interventions, bringing the development of critical awareness to the construction and promotion of a healthy diet, physical activity, and the monitoring of the nutritional status in childhood and adolescence. Objectives: To describe a study protocol to evaluate the effectiveness of an intervention designed to improve knowledge of food choices in the school environment. Methods: This is a cluster-randomized, parallel, two-arm study conducted in public elementary and middle schools in Brazil...
June 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28683433/childhood-trauma-and-suicide-attempt-a-meta-analysis-of-longitudinal-studies-from-the-last-decade
#13
REVIEW
Cleonice Zatti, Virgínia Rosa, Alcina Barros, Lucianne Valdivia, Vitor Crestani Calegaro, Lúcia Helena Freitas, Keila Maria Mendes Ceresér, Neusa Sica da Rocha, Andre Goettems Bastos, Felipe Barreto Schuch
Childhood trauma (CT) is a modifiable risk factor for lifetime suicide attempts (SA). However, the extent to which each type of CT increases SA risk is unclear. This study aimed to conduct a meta-analysis of longitudinal studies published in the last 10 years about the relationship between CT and lifetime SA risk. The PUBMED, PsycINFO, ISI, and EMBASE databases were searched for cohort studies that reported AS during follow-up and included an assessment of CT. A meta-analysis was conducted to identify potential effects of each type of CT on SA...
June 29, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28673550/a-rare-case-of-sterol-c4-methyl-oxidase-deficiency-in-a-young-italian-male-biochemical-and-molecular-characterization
#14
Giulia Frisso, Monica Gelzo, Elena Procopio, Concetta Sica, Maria Pia Lenza, Antonio Dello Russo, Maria Alice Donati, Francesco Salvatore, Gaetano Corso
Inborn defects of cholesterol biosynthesis are metabolic disorders presenting with multi-organ and tissue anomalies. An autosomal recessive defect involving the demethylating enzyme C4-methyl sterol (SC4MOL) has been reported in only 4 patients so far. In infancy, all patients were affected by microcephaly, bilateral congenital cataracts, growth delay, psoriasiform dermatitis, immune dysfunction, and intellectual disability. Herein, we describe a new case of SC4MOL deficiency in which a 19-year-old Italian male was affected by bilateral congenital cataracts, growth delay and learning disabilities, behavioral disorders and small stature, but not microcephaly...
June 27, 2017: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/28629435/eculizumab-treatment-stochastic-occurrence-of-c3-binding-to-individual-pnh-erythrocytes
#15
Michela Sica, Tommaso Rondelli, Patrizia Ricci, Maria De Angioletti, Antonio M Risitano, Rosario Notaro
BACKGROUND: C5 blockade by eculizumab prevents complement-mediated intravascular hemolysis in paroxysmal nocturnal hemoglobinuria (PNH). However, C3-bound PNH red blood cells (RBCs), arising in almost all treated patients, may undergo extravascular hemolysis reducing clinical benefits. Despite the uniform deficiency of CD55 and of CD59, there are always two distinct populations of PNH RBCs, with (C3+) and without (C3-) C3 binding. METHODS: To investigate this paradox, the phenomenon has been modeled in vitro by incubating RBCs from eculizumab untreated PNH patients with compatible sera containing eculizumab, and by assessing the C3 binding after activation of complement alternative pathway...
June 19, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28618326/inflammation-as-target-in-cancer-therapy
#16
REVIEW
Giulia Marelli, Antonio Sica, Luca Vannucci, Paola Allavena
Cells of the innate immunity infiltrating tumour tissues promote, rather than halt, cancer cell proliferation and distant spreading. Tumour-Associated Macrophages (TAMs) are abundantly present in the tumour milieu and here trigger and perpetrate a state of chronic inflammation which ultimately supports disease development and contributes to an immune-suppressive environment. Therapeutic strategies to limit inflammatory cells and their products have been successful in pre-clinical tumour models. Early clinical trials with specific cytokine and chemokine inhibitors, or with strategies designed to target TAMs, are on their way in different solid malignancies...
June 12, 2017: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/28608966/next-generation-sequencing-and-clinical-outcomes-of-patients-with-lung-adenocarcinoma-treated-with-stereotactic-body-radiotherapy
#17
Richard J Cassidy, Xinyan Zhang, Pretesh R Patel, Joseph W Shelton, Chase E Escott, Gabriel L Sica, Michael R Rossi, Charles E Hill, Conor E Steuer, Rathi N Pillai, Suresh S Ramalingam, Taofeek K Owonikoko, Madhusmita Behera, Seth D Force, Felix G Fernandez, Walter J Curran, Kristin A Higgins
BACKGROUND: Genetic aberrations are well characterized in lung adenocarcinomas (LACs) and clinical outcomes have been influenced by targeted therapies in the advanced setting. Stereotactic body radiotherapy (SBRT) is the standard-of-care therapy for patients with nonoperable, early-stage LAC, but to the authors' knowledge, no information is available regarding the impact of genomic changes in these patients. The current study sought to determine the frequency and clinical impact of genetic aberrations in this population...
June 13, 2017: Cancer
https://www.readbyqxmd.com/read/28602368/use-of-diuretics-in-the-treatment-of-heart-failure-in-older-adults
#18
REVIEW
Domenic A Sica, Todd W B Gehr, William H Frishman
Diuretics are the most commonly prescribed class of drugs in patients with heart failure, and in the short term they remain the most effective treatment for relief from fluid congestion. This article reviews the mode of action of the various diuretic classes and the physiologic adaptations that follow and sets up the basis for their use in the treatment of volume-retaining states, particularly as applies to the elderly. In addition, the article reviews the common side effects related to diuretics.
July 2017: Heart Failure Clinics
https://www.readbyqxmd.com/read/28571124/correction-pdgfr%C3%AE-depletion-attenuates-glioblastoma-stem-cells-features-by-modulation-of-stat3-rb1-and-multiple-oncogenic-signals
#19
Carlo Cenciarelli, Hany E Marei, Armando Felsani, Patrizia Casalbore, Gigliola Sica, Maria Ausiliatrice Puglisi, Angus Jm Cameron, Alessandro Olivi, Annunziato Mangiola
No abstract text is available yet for this article.
May 30, 2017: Oncotarget
https://www.readbyqxmd.com/read/28565928/iron-oxide-magnetic-nanoparticles-as-antimicrobials-for-therapeutics
#20
Lucas de Alcântara Sica de Toledo, Hélen Cássia Rosseto, Marcos Luciano Bruschi
The use of iron oxide magnetic nanoparticles (IMNP) in medical and pharmaceutical areas dates to the beginning of the 1970s, as carriers. Some other uses to these nanoparticles are in vitro separation, magnetic resonance imaging and drug targeting agent. Many preparations containing IMNP have been described and used in drug delivery, hyperthermia, in vitro separation, tissue repair, cellular therapy, for magnetic separation, magnetic resonance imaging, as spoilers for magnetic resonance spectroscopy, and more recently as sensors for metabolites and other biomolecules...
June 21, 2017: Pharmaceutical Development and Technology
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