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Jan burger

Thomas Martini, Christian Gilfrich, Roman Mayr, Maximilian Burger, Armin Pycha, Atiqullah Aziz, Michael Gierth, Christian G Stief, Stefan C Müller, Florian Wagenlehner, Jan Roigas, Oliver W Hakenberg, Florian Roghmann, Philipp Nuhn, Manfred Wirth, Vladimir Novotny, Boris Hadaschik, Marc-Oliver Grimm, Paul Schramek, Axel Haferkamp, Daniela Colleselli, Birgit Kloss, Edwin Herrmann, Margit Fisch, Matthias May, Christian Bolenz
INTRODUCTION: Guidelines recommend neoadjuvant chemotherapy (NAC) before radical cystectomy (RC) in patients with urothelial carcinoma of the bladder in clinical stages T2-T4a, cN0M0. We examined the frequency and current practice of NAC and sought to identify predictors for the use of NAC in a prospective contemporary cohort. MATERIALS AND METHODS: We analyzed prospective data from 679 patients in the PROMETRICS (PROspective MulticEnTer RadIcal Cystectomy Series 2011) database...
September 19, 2016: Clinical Genitourinary Cancer
Julien Soubrier, Graham Gower, Kefei Chen, Stephen M Richards, Bastien Llamas, Kieren J Mitchell, Simon Y W Ho, Pavel Kosintsev, Michael S Y Lee, Gennady Baryshnikov, Ruth Bollongino, Pere Bover, Joachim Burger, David Chivall, Evelyne Crégut-Bonnoure, Jared E Decker, Vladimir B Doronichev, Katerina Douka, Damien A Fordham, Federica Fontana, Carole Fritz, Jan Glimmerveen, Liubov V Golovanova, Colin Groves, Antonio Guerreschi, Wolfgang Haak, Tom Higham, Emilia Hofman-Kamińska, Alexander Immel, Marie-Anne Julien, Johannes Krause, Oleksandra Krotova, Frauke Langbein, Greger Larson, Adam Rohrlach, Amelie Scheu, Robert D Schnabel, Jeremy F Taylor, Małgorzata Tokarska, Gilles Tosello, Johannes van der Plicht, Ayla van Loenen, Jean-Denis Vigne, Oliver Wooley, Ludovic Orlando, Rafał Kowalczyk, Beth Shapiro, Alan Cooper
The two living species of bison (European and American) are among the few terrestrial megafauna to have survived the late Pleistocene extinctions. Despite the extensive bovid fossil record in Eurasia, the evolutionary history of the European bison (or wisent, Bison bonasus) before the Holocene (<11.7 thousand years ago (kya)) remains a mystery. We use complete ancient mitochondrial genomes and genome-wide nuclear DNA surveys to reveal that the wisent is the product of hybridization between the extinct steppe bison (Bison priscus) and ancestors of modern cattle (aurochs, Bos primigenius) before 120 kya, and contains up to 10% aurochs genomic ancestry...
October 18, 2016: Nature Communications
Rohit Mathur, Lalit Sehgal, Ondrej Havranek, Stefan Köhrer, Tamer Khashab, Neeraj Jain, Jan A Burger, Sattva S Neelapu, R Eric Davis, Felipe Samaniego
Histone methylation and demethylation regulates B-cell development, and their deregulation correlates with tumor chemoresistance in diffuse large B-cell lymphoma, limiting curative rates. Since histone methylation status correlates with disease aggressiveness and relapse, we investigated the therapeutic potential of inhibiting histone 3 Lys27 demethylase KDM6B, in-vitro, using the small molecule inhibitor GSK-J4. KDM6B is overexpressed in the DLBCL germinal center B-cell subtype, and higher KDM6B levels are associated with worse survival in DLBCL patients treated with R-CHOP...
October 14, 2016: Haematologica
Matthew D Blunt, Stefan Koehrer, Rachel Dobson, Marta Larrayoz, Sarah Wilmore, Alice Hayman, Jack Parnell, Lindsay D Smith, Andrew Davies, Peter Wm Johnson, Pamela B Conley, Anjali Pandey, Jonathan C Strefford, Freda K Stevenson, Graham Packham, Francesco Forconi, Greg P Coffey, Jan Burger, Andrew J Steele
PURPOSE: B-cell receptor (BCR)-associated kinase inhibitors such as ibrutinib have revolutionised the treatment of chronic lymphocytic leukemia (CLL). However, these agents are not curative and resistance is already emerging in a proportion of patients. Interleukin-4 (IL-4), expressed in CLL lymph nodes, can augment BCR-signalling and reduce the effectiveness of BCR-kinase inhibitors. Therefore simultaneous targeting of the IL-4- and BCR-signalling pathways by cerdulatinib, a novel dual Syk/JAK inhibitor currently in clinical trials (NCT01994382), may improve treatment responses in patients...
October 3, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Brittany Knick Ragon, Hagop Kantarjian, Elias Jabbour, Farhad Ravandi, Jorge Cortes, Gautam Borthakur, LaKiesha DeBose, Zhihong Zeng, Heather Schneider, Naveen Pemmaraju, Guillermo Garcia-Manero, Steven Kornblau, William Wierda, Jan Burger, Courtney D DiNardo, Michael Andreeff, Marina Konopleva, Naval Daver
Phosphatidylinositol-3-kinase (PI3K) signaling plays a crucial role in oncogene-mediated tumor growth and proliferation. Buparlisib (BKM120) is an oral pan-class I PI3K inhibitor. This phase I study was conducted to determine the dose limiting toxicity (DLT) and maximum tolerated dose (MTD) of BKM120 in patients (pts) with relapsed/refractory acute leukemias. Fourteen pts (12 acute myeloid leukemia, 1 acute lymphoblastic leukemia, 1 mixed phenotype leukemia) were enrolled. Twelve pts received BKM-120 80 mg/day and two 100 mg/day...
September 27, 2016: American Journal of Hematology
Harun Bilgili, Matthias Bürger, Cosima Stubenrauch, Jan H Porada
HYPOTHESIS: Many efforts have been made to formulate water-IL microemulsions. One of the most intensely studied systems is H2O - 1-butyl-3-methylimidazolium hexafluorophosphate ([BMIm]PF6) - 4-octylphenol polyethoxylate (TX-100) and it is not questioned that this system forms microemulsions. The nanostructures observed for traditional microemulsions are postulated with the surfactant being adsorbed at the interface such that the hydrophilic EO sides intrude into the water domains, while the hydrophobic hydrocarbon chains are immersed into [BMIm]PF6...
December 15, 2016: Journal of Colloid and Interface Science
Stefania Fiorcari, Rossana Maffei, Valentina Audrito, Silvia Martinelli, Elisa Ten Hacken, Patrizia Zucchini, Giulia Grisendi, Leonardo Potenza, Mario Luppi, Jan A Burger, Silvia Deaglio, Roberto Marasca
In lymphoid organs, nurse-like cells (NLCs) show properties of tumor-associated macrophages, playing a crucial role in chronic lymphocytic leukemia (CLL) cell survival. Ibrutinib, a potent inhibitor of Bruton's tyrosine kinase (BTK), is able to counteract pro-survival signals in CLL cells. Since the effects on CLL cells have been studied in the last years, less is known about the influence of ibrutinib on NLCs properties. We sought to determine how ibrutinib modifies NLCs functions focusing on the balance between immunosuppressive and inflammatory features...
September 1, 2016: Oncotarget
Sheng He, Petros Samara, Jan Burgers, Lambert Schomaker
It is of essential importance for historians to know the date and place of origin of the documents they study. It would be a huge advancement for historical scholars if it would be possible to automatically estimate the geographical and temporal provenance of a handwritten document by inferring them from the handwriting style of such a document. We propose a multiple-label guided clustering algorithm to discover the correlations between the concrete low-level visual elements in historical documents and abstract labels, such as date and location...
November 2016: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
Elisa Ten Hacken, Mariela Sivina, Ekaterina Kim, Susan O'Brien, William G Wierda, Alessandra Ferrajoli, Zeev Estrov, Michael J Keating, Thomas Oellerich, Cristina Scielzo, Paolo Ghia, Federico Caligaris-Cappio, Jan A Burger
BCR signaling is a central pathogenetic pathway in chronic lymphocytic leukemia (CLL). Most CLL cells express BCRs of IgM and IgD isotypes, but the contribution of these isotypes to functional responses remains incompletely defined. We therefore investigated differences between IgM and IgD signaling in freshly isolated peripheral blood CLL cells and in CLL cells cultured with nurselike cells, a model that mimics the lymph node microenvironment. IgM signaling induced prolonged activation of ERK kinases and promoted CLL cell survival, CCL3 and CCL4 chemokine secretion, and downregulation of BCL6, the transcriptional repressor of CCL3 In contrast, IgD signaling induced activation of the cytoskeletal protein HS1, along with F-actin polymerization, which resulted in rapid receptor internalization and failure to support downstream responses, including CLL cell survival and chemokine secretion...
September 15, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
Georgios Gakis, Jason A Efstathiou, Siamak Daneshmand, Kirk A Keegan, Rebecca H Clayman, Jan Hrbacek, Bedeir Ali-El-Dein, Harras B Zaid, Tina Schubert, Johannes Mischinger, Tilman Todenhöfer, Sigolene Galland, Kola Olugbade, Michael Rink, Hans-Martin Fritsche, Maximilian Burger, Sam S Chang, Marko Babjuk, George N Thalmann, Arnulf Stenzl, Todd M Morgan
INTRODUCTION: The study aimed to investigate oncological outcomes of patients with concomitant bladder cancer (BC) and urethral carcinoma. METHODS: This is a multicenter series of 110 patients (74 men, 36 women) diagnosed with urethral carcinoma at 10 referral centers between 1993 and 2012. Kaplan-Meier analysis was used to investigate the impact of BC on survival, and Cox regression multivariable analysis was performed to identify predictors of recurrence. RESULTS: Synchronous BC was diagnosed in 13 (12%) patients, and the median follow-up was 21 months (interquartile range 4-48)...
2016: Urologia Internationalis
Bartholomeus C M 'Benno' Haarman, Rixt F Riemersma-Van der Lek, Huibert Burger, Jan Cees de Groot, Hemmo A Drexhage, Willem A Nolen, Leonardo Cerliani
BACKGROUND: In the current DTI study we compared euthymic bipolar I disorder (BD-I) patients and healthy controls (HC). We subsequently divided the total patient group into lithium-users and non-lithium-users and estimated differences across the three groups. METHODS: Twenty-one euthymic BD-I patients and twenty-two HC participants were included in psychiatric interviews and MRI image acquisition (diffusion-weighted (DW) and T1-weighted scans). Fractional anisotropy (FA), radial, mean and axial diffusivity (RD, MD, AD) were estimated from the DW data, using DTI...
October 2016: Journal of Affective Disorders
Bartholomeus C M 'Benno' Haarman, Huibert Burger, Janine Doorduin, Remco J Renken, Anita J Sibeijn-Kuiper, Jan-Bernard C Marsman, Erik F J de Vries, Jan Cees de Groot, Hemmo A Drexhage, Richard Mendes, Willem A Nolen, Rixt F Riemersma-Van der Lek
No abstract text is available yet for this article.
June 13, 2016: Brain, Behavior, and Immunity
Dai Chihara, Hagop Kantarjian, Susan O'Brien, Jeffrey Jorgensen, Sherry Pierce, Stefan Faderl, Alessandra Ferrajoli, Rebecca Poku, Preetesh Jain, Phillip Thompson, Mark Brandt, Rajyalakshmi Luthra, Jan Burger, Michael Keating, Farhad Ravandi
Nucleoside analogues are highly active in patients with hairy cell leukaemia (HCL); however, patients continue to relapse. This phase II study evaluated the efficacy and safety of cladribine followed by rituximab in patients with untreated HCL (N = 59), relapsed HCL (N = 14) and HCL variant (HCLv, N = 7). Cladribine 5·6 mg/m(2) was given intravenously (IV) daily for 5 d and was followed approximately 1 month later with rituximab 375 mg/m(2) IV weekly for 8 weeks. Complete response rate in patients with untreated HCL, relapsed HCL and HCLv was 100%, 100% and 86%, respectively...
September 2016: British Journal of Haematology
Stefan Vallo, Christian Gilfrich, Maximilian Burger, Björn Volkmer, Katharina Boehm, Michael Rink, Felix K Chun, Florian Roghmann, Vladimir Novotny, Jens Mani, Antonin Brisuda, Roman Mayr, Regina Stredele, Joachim Noldus, Marco Schnabel, Matthias May, Hans-Martin Fritsche, Armin Pycha, Thomas Martini, Manfred Wirth, Jan Roigas, Patrick J Bastian, Philipp Nuhn, Roland Dahlem, Axel Haferkamp, Margit Fisch, Atiqullah Aziz
PURPOSE: To evaluate the prognostic relevance of different prostatic invasion patterns in pT4a urothelial carcinoma of the bladder (UCB) after radical cystectomy. MATERIALS AND METHODS: Our study comprised a total of 358 men with pT4a UCB. Patients were divided in 2 groups-group A with stromal infiltration of the prostate via the prostatic urethra with additional muscle-invasive UCB (n = 121, 33.8%) and group B with continuous infiltration of the prostate through the entire bladder wall (n = 237, 66...
October 2016: Urologic Oncology
Luis M Corrochano, Alan Kuo, Marina Marcet-Houben, Silvia Polaino, Asaf Salamov, José M Villalobos-Escobedo, Jane Grimwood, M Isabel Álvarez, Javier Avalos, Diane Bauer, Ernesto P Benito, Isabelle Benoit, Gertraud Burger, Lola P Camino, David Cánovas, Enrique Cerdá-Olmedo, Jan-Fang Cheng, Angel Domínguez, Marek Eliáš, Arturo P Eslava, Fabian Glaser, Gabriel Gutiérrez, Joseph Heitman, Bernard Henrissat, Enrique A Iturriaga, B Franz Lang, José L Lavín, Soo Chan Lee, Wenjun Li, Erika Lindquist, Sergio López-García, Eva M Luque, Ana T Marcos, Joel Martin, Kevin McCluskey, Humberto R Medina, Alejandro Miralles-Durán, Atsushi Miyazaki, Elisa Muñoz-Torres, José A Oguiza, Robin A Ohm, María Olmedo, Margarita Orejas, Lucila Ortiz-Castellanos, Antonio G Pisabarro, Julio Rodríguez-Romero, José Ruiz-Herrera, Rosa Ruiz-Vázquez, Catalina Sanz, Wendy Schackwitz, Mahdi Shahriari, Ekaterina Shelest, Fátima Silva-Franco, Darren Soanes, Khajamohiddin Syed, Víctor G Tagua, Nicholas J Talbot, Michael R Thon, Hope Tice, Ronald P de Vries, Ad Wiebenga, Jagjit S Yadav, Edward L Braun, Scott E Baker, Victoriano Garre, Jeremy Schmutz, Benjamin A Horwitz, Santiago Torres-Martínez, Alexander Idnurm, Alfredo Herrera-Estrella, Toni Gabaldón, Igor V Grigoriev
Plants and fungi use light and other signals to regulate development, growth, and metabolism. The fruiting bodies of the fungus Phycomyces blakesleeanus are single cells that react to environmental cues, including light, but the mechanisms are largely unknown [1]. The related fungus Mucor circinelloides is an opportunistic human pathogen that changes its mode of growth upon receipt of signals from the environment to facilitate pathogenesis [2]. Understanding how these organisms respond to environmental cues should provide insights into the mechanisms of sensory perception and signal transduction by a single eukaryotic cell, and their role in pathogenesis...
June 20, 2016: Current Biology: CB
Dominique Burger, Martine Stihle, Ashwani Sharma, Paola Di Lello, Jörg Benz, Brigitte D'Arcy, Maja Debulpaep, David Fry, Walter Huber, Thomas Kremer, Toon Laeremans, Hugues Matile, Alfred Ross, Arne C Rufer, Guillaume Schoch, Michel O Steinmetz, Jan Steyaert, Markus G Rudolph, Ralf Thoma, Armin Ruf
Doublecortin is a microtubule-associated protein produced during neurogenesis. The protein stabilizes microtubules and stimulates their polymerization, which allows migration of immature neurons to their designated location in the brain. Mutations in the gene that impair doublecortin function and cause severe brain formation disorders are located on a tandem repeat of two doublecortin domains. The molecular mechanism of action of doublecortin is only incompletely understood. Anti-doublecortin antibodies, such as the rabbit polyclonal Abcam 18732, are widely used as neurogenesis markers...
July 29, 2016: Journal of Biological Chemistry
Jan A Burger, Dan A Landau, Amaro Taylor-Weiner, Ivana Bozic, Huidan Zhang, Kristopher Sarosiek, Lili Wang, Chip Stewart, Jean Fan, Julia Hoellenriegel, Mariela Sivina, Adrian M Dubuc, Cameron Fraser, Yulong Han, Shuqiang Li, Kenneth J Livak, Lihua Zou, Youzhong Wan, Sergej Konoplev, Carrie Sougnez, Jennifer R Brown, Lynne V Abruzzo, Scott L Carter, Michael J Keating, Matthew S Davids, William G Wierda, Kristian Cibulskis, Thorsten Zenz, Lillian Werner, Paola Dal Cin, Peter Kharchencko, Donna Neuberg, Hagop Kantarjian, Eric Lander, Stacey Gabriel, Susan O'Brien, Anthony Letai, David A Weitz, Martin A Nowak, Gad Getz, Catherine J Wu
Resistance to the Bruton's tyrosine kinase (BTK) inhibitor ibrutinib has been attributed solely to mutations in BTK and related pathway molecules. Using whole-exome and deep-targeted sequencing, we dissect evolution of ibrutinib resistance in serial samples from five chronic lymphocytic leukaemia patients. In two patients, we detect BTK-C481S mutation or multiple PLCG2 mutations. The other three patients exhibit an expansion of clones harbouring del(8p) with additional driver mutations (EP300, MLL2 and EIF2A), with one patient developing trans-differentiation into CD19-negative histiocytic sarcoma...
2016: Nature Communications
Philip A Thompson, Francesco Stingo, Michael J Keating, Alessandra Ferrajoli, Jan A Burger, William G Wierda, Tapan M Kadia, Susan M O'Brien
BACKGROUND: More active therapies are needed for older and unfit patients with chronic lymphocytic leukemia (CLL) who are not eligible for chemoimmunotherapy with fludarabine, cyclophosphamide, and rituximab. The phosphyotidylinositol-3-kinase δ inhibitor idelalisib is effective in patients with treatment-naive and relapsed/refractory CLL as monotherapy and in combination with rituximab, but it can be associated with treatment-limiting adverse events, particularly diarrhea/colitis. The outcomes for patients who cease treatment for adverse events have not been previously described...
August 15, 2016: Cancer
Steven E Coutre, Jan A Burger, John M Pagel
No abstract text is available yet for this article.
May 2016: Clinical Advances in Hematology & Oncology: H&O
Jan A Burger
No abstract text is available yet for this article.
May 2016: Clinical Advances in Hematology & Oncology: H&O
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