keyword
MENU ▼
Read by QxMD icon Read
search

ECN

keyword
https://www.readbyqxmd.com/read/29912668/student-response-to-reports-of-unprofessional-behavior-assessing-risk-of-subsequent-professional-problems-in-medical-school
#1
Michael A Ainsworth, Karen M Szauter
BACKGROUND: An early concern note (ECN) program is used by some medical schools to identify, counsel, and intervene when students exhibit unprofessional behavior. Student maturity, insight, propensity for reflection, and receptiveness to feedback have been suggested as predictors of future behavior. OBJECTIVE: We hypothesized that (a) classifying students with a first ECN based on their response to the report would identify students at risk of repeat ECNs better than the action that prompted it and (b) receipt of multiple ECNs would identify students at risk of adverse academic events...
December 2018: Medical Education Online
https://www.readbyqxmd.com/read/29909301/intrinsic-functional-neurocircuitry-associated-with-treatment-response-to-transdiagnostic-cbt-in-bipolar-disorder-with-anxiety
#2
Kristen K Ellard, Aishwarya G Gosai, Emily E Bernstein, Navneet Kaur, Lousia G Sylvia, Joan A Camprodon, Darin D Dougherty, Andrew A Nierenberg, Thilo Deckersbach
BACKGROUND: Anxiety in bipolar disorder (BD) exacerbates emotion dysregulation and reduces treatment response. We recently conducted a pilot trial of transdiagnostic CBT to target anxiety and emotion dysregulation in BD adjunctive to pharmacotherapy. Reductions in depression and anxiety symptoms were significantly predicted by baseline levels of neuroticism and perceived affective control, as well as changes over time in emotion regulation skills. The present study investigates mechanism of treatment response by examining the relationship between baseline emotion regulation-related neural circuitry and trial outcomes...
June 2, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29896160/the-probiotic-escherichia-coli-strain-nissle-1917-combats-lambdoid-bacteriophages-stx-and-%C3%AE
#3
Susanne Bury, Manonmani Soundararajan, Richa Bharti, Rudolf von Bünau, Konrad U Förstner, Tobias A Oelschlaeger
Shiga toxin (Stx) producing E. coli (STEC) such as Enterohemorrhagic E. coli (EHEC) are the major cause of foodborne illness in humans. In vitro studies showed the probiotic Escherichia coli strain Nissle 1917 (EcN) to efficiently inhibit the production of Stx. Life threatening EHEC strains as for example the serotype O104:H4, responsible for the great outbreak in 2011 in Germany, evolutionary developed from certain E. coli strains which got infected by stx2 -encoding lambdoid phages turning the E. coli into lysogenic and subsequently Stx producing strains...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29890337/neuroprotection-against-6-ohda-toxicity-in-pc12-cells-and-mice-through-the-nrf2-pathway-by-a-sesquiterpenoid-from-tussilago-farfara
#4
Joohee Lee, Kwangho Song, Eugene Huh, Myung Sook Oh, Yeong Shik Kim
Oxidative stress plays a key role in neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. Therefore, the nuclear factor-E2-related factor 2 (Nrf2), a key regulator of the antioxidative response, is considered to be important as a therapeutic target for neurodegenerative diseases. We investigated the underlying mechanism of Nrf2-mediated neuroprotective effects against oxidative stress in the PC12 cell line by 7β-(3-ethyl-cis-crotonoyloxy)-1α-(2-methylbutyryloxy)-3,14-dehydro-Z-notonipetranone (ECN), one of the sesquiterpenoids in Farfarae Flos...
June 1, 2018: Redox Biology
https://www.readbyqxmd.com/read/29867727/aberrant-effective-connectivity-of-the-right-anterior-insula-in-primary-insomnia
#5
Chao Li, Mengshi Dong, Yi Yin, Kelei Hua, Shishun Fu, Guihua Jiang
Objective: Daytime cognitive impairment is an essential symptom of primary insomnia (PI). However, the underlying neural substrate remains largely unknown. Many studies have shown that the right anterior insula (rAI) as a key node of salience network (SN) plays a critical role in switching between the executive control network (ECN) and the default mode network (DMN) for better performance of cognitively demanding tasks. Aberrant effective connectivity (directional functional connectivity) of rAI with ECN or DMN may be one reason for daytime cognitive impairment in PI patients...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29867475/the-administration-of-escherichia-coli-nissle-1917-ameliorates-development-of-dss-induced-colitis-in-mice
#6
Alba Rodríguez-Nogales, Francesca Algieri, José Garrido-Mesa, Teresa Vezza, Maria P Utrilla, Natalia Chueca, Jose A Fernández-Caballero, Federico García, Maria E Rodríguez-Cabezas, Julio Gálvez
The beneficial effects of probiotics on immune-based pathologies such as inflammatory bowel disease (IBD) have been well reported. However, their exact mechanisms have not been fully elucidated. Few studies have focused on the impact of probiotics on the composition of the colonic microbiota. The aim of the present study was to correlate the intestinal anti-inflammatory activity of the probiotic Escherichia coli Nissle 1917 (EcN) in the dextran sodium sulfate (DSS) model of mouse colitis with the changes induced in colonic microbiota populations...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29863797/effects-of-lactobacillus-rhamnosus-gg-and-escherichia-coli-nissle-1917-cell-free-supernatants-on-modulation-of-mucin-and-cytokine-secretion-on-human-intestinal-epithelial-ht29-mtx-cells
#7
Murphy Lam-Yim Wan, Zhijian Chen, Nagendra P Shah, Hani El-Nezami
This study examined modulation effects of cell-free supernatants of two commonly studied probiotic bacteria Lactobacillus rhamnosus GG (LGG) and Escherichia coli Nissle 1917 (EcN) on mucin and cytokine profiles of human intestinal epithelial HT29-MTX cells. It was found that LGG and EcN supernatants differentially modulated MUC5AC and MUC5B mRNA and protein, and total mucin-like glycoprotein secretion. Regarding modulation of cytokine profiles, LGG supernatants moderately influenced the secretion of anti-inflammatory cytokines such as interleukin (IL)-4, IL-5, and IL-10, while those of EcN exerted a broad proinflammatory effect to intestinal epithelial cells by inducing the secretion of proinflammatory cytokines such as IL-8, monocyte chemotactic protein-1, transforming growth factor α, tumor necrosis factor α, granulocyte macrophage colony-stimulating factor, and interferon γ...
June 4, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29713493/prophylaxis-of-acute-respiratory-infections-via-improving-the-immune-system-in-late-preterm-newborns-with-e-coli-strain-nissle-1917-a-controlled-pilot-trial
#8
Mykola L Aryayev, Liudmyla I Senkivska, Nataliya K Bredeleva, Irina V Talashova
Background: Acute respiratory infections (ARIs), caused by the high level of immaturity of the immune system, are a major cause of morbidity in preterm newborns. The probiotic Escherichia coli strain Nissle 1917 (EcN) is well known for its immuno-modulatory properties and may therefore enhance the immune competence. Thus, EcN administration may provide a promising possibility to decrease the risk of ARIs in this vulnerable group of children. However, clinical data supporting or refuting this hypothesis are, to our knowledge, not available...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29699674/mechanistic-insight-into-the-relationship-between-triacylglycerol-and-crystallization-of-lipase-catalyzed-interesterified-blend-of-palm-stearin-and-vegetable-oil
#9
Ting-Wei Zhu, Hao-Tian Weng, Xia Zhang, Hong Wu, Bing Li
To give a deep insight into the relationship between triacylglycerol and crystallization of interesterified fat, the blends of palm stearin and various vegetable oil were catalyzed by two different immobilized lipases in this study. After interesterification, the blends had wider plastic range indicated by the SFC results and more β' crystal. The improved physicochemical characteristics of interesterified blends were attributed to their changed TAG profiles. The statistical analysis showed that the interesterified blends were more likely to form β' crystal with the increase of SU2 -type TAG content and the decrease of SSS-type TAG content (p < 0...
September 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29695961/altered-functional-connectivity-of-insular-subregions-in-alzheimer-s-disease
#10
Xingyun Liu, Xiaodan Chen, Weimin Zheng, Mingrui Xia, Ying Han, Haiqing Song, Kuncheng Li, Yong He, Zhiqun Wang
Recent researches have demonstrated that the insula is the crucial hub of the human brain networks and most vulnerable region of Alzheimer's disease (AD). However, little is known about the changes of functional connectivity of insular subregions in the AD patients. In this study, we collected resting-state functional magnetic resonance imaging (fMRI) data including 32 AD patients and 38 healthy controls (HCs). By defining three subregions of insula, we mapped whole-brain resting-state functional connectivity (RSFC) and identified several distinct RSFC patterns of the insular subregions: For positive connectivity, three cognitive-related RSFC patterns were identified within insula that suggest anterior-to-posterior functional subdivisions: (1) an dorsal anterior zone of the insula that exhibits RSFC with executive control network (ECN); (2) a ventral anterior zone of insula, exhibits functional connectivity with the salience network (SN); (3) a posterior zone along the insula exhibits functional connectivity with the sensorimotor network (SMN)...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29691945/altered-intra-and-inter-network-functional-coupling-of-resting-state-networks-associated-with-motor-dysfunction-in-stroke
#11
Zhiyong Zhao, Jie Wu, Mingxia Fan, Dazhi Yin, Chaozheng Tang, Jiayu Gong, Guojun Xu, Xinjie Gao, Qiurong Yu, Hao Yang, Limin Sun, Jie Jia
Motor functions are supported through functional integration across the extended motor system network. Individuals following stroke often show deficits on motor performance requiring coordination of multiple brain networks; however, the assessment of connectivity patterns after stroke was still unclear. This study aimed to investigate the changes in intra- and inter-network functional connectivity (FC) of multiple networks following stroke and further correlate FC with motor performance. Thirty-three left subcortical chronic stroke patients and 34 healthy controls underwent resting-state functional magnetic resonance imaging...
April 24, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29688444/identification-of-a-contact-dependent-growth-inhibition-system-in-the-probiotic-escherichia-coli-nissle-1917
#12
Hanna Chen, Qian Fang, Qiang Tu, Chenlang Liu, Jia Yin, Yulong Yin, Liqiu Xia, Xiaoying Bian, Youming Zhang
Contact-dependent growth inhibition (CDI) is a type of competitive mechanisms and has been identified in various strains including Burkholderia, Dickeya, E. coli and Yersinia. Classical CDI systems contain three genes, cdiB, cdiA and cdiI. CdiB encoded by cdiB gene is a conserved β-barrel protein and required for export of CdiA. CdiA protein encoded by cdiA gene includes a conserved N-terminal domain and variable C-terminal toxic domain (CdiA-CT). Immunity protein CdiI binds and inactivates toxin protein CdiA-CT...
June 1, 2018: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/29670910/regiospecific-analysis-of-fatty-acids-and-calculation-of-triglyceride-molecular-species-in-marine-fish-oils
#13
Huijun Zhang, Yingbin Shen, Youwei Zhang, Lirong Li, Xingguo Wang
The regiospecific distribution of fatty acids (FAs) and composition of triglyceride (TAG) molecular species of fishes were analyzed and calculated by pancreatic lipase (PL) hydrolysis and Visual Basic (VB) program. DHA was preferentially located at sn-2 position in TAG molecule, whereas EPA was almost equally distributed in each position of glycerol backbone. DOP, DPP, EPP, PoPP, PPO, and PPP were the predominant TAG species. MPP in anchovy, DDP, DOP, DPP in tuna, and EOO and OOO in salmon were the characteristic TAG molecules, which were meaningful to differentiate marine fish oils...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29665711/is-rest-really-rest-resting-state-functional-connectivity-during-rest-and-motor-task-paradigms
#14
Michael T Jurkiewicz, Adrian P Crawley, David J Mikulis
Numerous studies have identified the default mode network (DMN) within the brain of healthy individuals, which has been attributed to the ongoing mental activity of the brain during the wakeful resting-state. While engaged during specific resting-state fMRI paradigms, it remains unclear as to whether traditional block-design simple movement fMRI experiments significantly influence the default mode network or other areas. Using blood-oxygen level dependent (BOLD) fMRI we characterized the pattern of functional connectivity in healthy subjects during a resting-state paradigm and compared this to the same resting-state analysis performed on motor task data residual time courses after regressing out the task paradigm...
April 18, 2018: Brain Connectivity
https://www.readbyqxmd.com/read/29658696/improved-method-for-the-incorporation-of-heme-cofactors-into-recombinant-proteins-using-escherichia-coli-nissle-1917
#15
Kerstin Fiege, Christine Joy Querebillo, Peter Hildebrandt, Nicole Frankenberg-Dinkel
Recombinant production of heme proteins in Escherichia coli is often limited by the availability of heme in the host. Therefore, several methods, including the reconstitution of heme proteins after production but prior to purification or the HPEX system, conferring the ability to take up external heme have been developed and used in the past. Here we describe the use of the apathogenic E. coli strain Nissle 1917 (EcN) as a suitable host for the recombinant production of heme proteins. EcN has an advantage over commonly used lab strains in that it is able to take up heme from the environment through the heme receptor ChuA...
May 15, 2018: Biochemistry
https://www.readbyqxmd.com/read/29626649/random-forest-based-classification-of-alcohol-dependence-patients-and-healthy-controls-using-resting-state-mri
#16
Xi Zhu, Xiaofei Du, Mike Kerich, Falk W Lohoff, Reza Momenan
Currently, classification of alcohol use disorder (AUD) is made on clinical grounds; however, robust evidence shows that chronic alcohol use leads to neurochemical and neurocircuitry adaptations. Identifications of the neuronal networks that are affected by alcohol would provide a more systematic way of diagnosis and provide novel insights into the pathophysiology of AUD. In this study, we identified network-level brain features of AUD, and further quantified resting-state within-network, and between-network connectivity features in a multivariate fashion that are classifying AUD, thus providing additional information about how each network contributes to alcoholism...
May 29, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29611075/presurgical-localization-and-spatial-shift-of-resting-state-networks-in-patients-with-brain-metastases
#17
Ju-Rong Ding, Fangmei Zhu, Bo Hua, Xingzhong Xiong, Yuqiao Wen, Zhongxiang Ding, Paul M Thompson
Brain metastases are the most prevalent cerebral tumors. Resting state networks (RSNs) are involved in multiple perceptual and cognitive functions. Therefore, precisely localizing multiple RSNs may be extremely valuable before surgical resection of metastases, to minimize neurocognitive impairments. Here we aimed to investigate the reliability of independent component analysis (ICA) for localizing multiple RSNs from resting-state functional MRI (rs-fMRI) data in individual patients, and further evaluate lesion-related spatial shifts of the RSNs...
April 2, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29606906/small-supernumerary-marker-chromosome-may-provide-information-on-dosage-insensitive-pericentric-regions-in-human
#18
Ahmed B Hamid Al-Rikabi, Sona Pekova, Xioabo Fan, Tereza Jančušková, Thomas Liehr
Background: Cytogenetically visible chromosomal imbalances in humans are deleterious and adverse in the majority of the cases. However, healthy persons living with chromosomal imbalances in the range of several megabasepairs (Mbps) in size, like carriers of small Supernumerary Marker Chromosomes (sSMCs) exist. Materials & Methods: The identification of healthy sSMC carriers with euchromatic centromere-near (ECN) imbalances led to the following proposal: ECN-regions do not contain any dosage sensitive genes...
April 2018: Current Genomics
https://www.readbyqxmd.com/read/29606606/gender-specific-effect-of-uric-acid-on-resting-state-functional-networks-in-de-novo-parkinson-s-disease
#19
Yoonju Lee, Yeong-Hun Park, Jae Jung Lee, Young H Sohn, Jong-Min Lee, Phil Hyu Lee
INTRODUCTION: The pattern of resting-state networks is influenced by several factors besides the underlying pathological changes of Parkinson's disease (PD). Uric acid (UA), as an antioxidant, has a neuroprotective property against PD-related microenvironment; however, this effect would be gender-specific. We aimed to evaluate a gender-sensitive resting-state networks (RSN) according to the UA level in drug naïve de novo patients with PD to elucidate the role of antioxidant in cortical functional networks of PD...
March 26, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29580768/functional-connectivity-between-anterior-insula-and-key-nodes-of-frontoparietal-executive-control-and-salience-networks-distinguish-bipolar-depression-from-unipolar-depression-and-healthy-control-subjects
#20
Kristen K Ellard, Jared P Zimmerman, Navneet Kaur, Koene R A Van Dijk, Joshua L Roffman, Andrew A Nierenberg, Darin D Dougherty, Thilo Deckersbach, Joan A Camprodon
BACKGROUND: Patients with bipolar depression are characterized by dysregulation across the full spectrum of mood, differentiating them from patients with unipolar depression. The ability to switch neural resources among the default mode network, salience network, and executive control network (ECN) has been proposed as a key mechanism for adaptive mood regulation. The anterior insula is implicated in the modulation of functional network switching. Differential connectivity between anterior insula and functional networks may provide insights into pathophysiological differences between bipolar and unipolar mood disorders, with implications for diagnosis and treatment...
May 2018: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
keyword
keyword
30219
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"