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https://www.readbyqxmd.com/read/29670910/regiospecific-analysis-of-fatty-acids-and-calculation-of-triglyceride-molecular-species-in-marine-fish-oils
#1
Huijun Zhang, Yingbin Shen, Youwei Zhang, Lirong Li, Xingguo Wang
The regiospecific distribution of fatty acids (FAs) and composition of triglyceride (TAG) molecular species of fishes were analyzed and calculated by pancreatic lipase (PL) hydrolysis and Visual Basic (VB) program. DHA was preferentially located at sn-2 position in TAG molecule, whereas EPA was almost equally distributed in each position of glycerol backbone. DOP, DPP, EPP, PoPP, PPO, and PPP were the predominant TAG species. MPP in anchovy, DDP, DOP, DPP in tuna, and EOO and OOO in salmon were the characteristic TAG molecules, which were meaningful to differentiate marine fish oils...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29665711/is-rest-really-rest-resting-state-functional-connectivity-during-rest-and-motor-task-paradigms
#2
Michael T Jurkiewicz, Adrian P Crawley, David J Mikulis
Numerous studies have identified the default mode network (DMN) within the brain of healthy individuals, which has been attributed to the ongoing mental activity of the brain during the wakeful resting-state. While engaged during specific resting-state fMRI paradigms, it remains unclear as to whether traditional block-design simple movement fMRI experiments significantly influence the default mode network or other areas. Using blood-oxygen level dependent (BOLD) fMRI we characterized the pattern of functional connectivity in healthy subjects during a resting-state paradigm and compared this to the same resting-state analysis performed on motor task data residual time courses after regressing out the task paradigm...
April 18, 2018: Brain Connectivity
https://www.readbyqxmd.com/read/29658696/improved-method-for-the-incorporation-of-heme-cofactors-into-recombinant-proteins-using-escherichia-coli-nissle-1917
#3
Kerstin Fiege, Christine Joy Querebillo, Peter Hildebrandt, Nicole Frankenberg-Dinkel
Recombinant production of heme proteins in Escherichia coli is often limited by the availability of heme in the host. Therefore, several methods, including the reconstitution of heme proteins after production but prior to purification or the HPEX system conferring the ability to take up external heme have been developed and used in the past. Here we describe the use of the apathogenic Escherichia coli strain Nissle 1917 (EcN) as a suitable host for the recombinant production of heme proteins. EcN has the advantage over commonly used lab strains that it is able to take up heme from the environment through the heme receptor ChuA...
April 16, 2018: Biochemistry
https://www.readbyqxmd.com/read/29626649/random-forest-based-classification-of-alcohol-dependence-patients-and-healthy-controls-using-resting-state-mri
#4
Xi Zhu, Xiaofei Du, Mike Kerich, Falk W Lohoff, Reza Momenan
Currently, classification of alcohol use disorder (AUD) is made on clinical grounds; however, robust evidence shows that chronic alcohol use leads to neurochemical and neurocircuitry adaptations. Identifications of the neuronal networks that are affected by alcohol would provide a more systematic way of diagnosis and provide novel insights into the pathophysiology of AUD. In this study, we identified network-level brain features of AUD, and further quantified resting-state within-network, and between-network connectivity features in a multivariate fashion that are classifying AUD, thus providing additional information about how each network contributes to alcoholism...
April 4, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29611075/presurgical-localization-and-spatial-shift-of-resting-state-networks-in-patients-with-brain-metastases
#5
Ju-Rong Ding, Fangmei Zhu, Bo Hua, Xingzhong Xiong, Yuqiao Wen, Zhongxiang Ding, Paul M Thompson
Brain metastases are the most prevalent cerebral tumors. Resting state networks (RSNs) are involved in multiple perceptual and cognitive functions. Therefore, precisely localizing multiple RSNs may be extremely valuable before surgical resection of metastases, to minimize neurocognitive impairments. Here we aimed to investigate the reliability of independent component analysis (ICA) for localizing multiple RSNs from resting-state functional MRI (rs-fMRI) data in individual patients, and further evaluate lesion-related spatial shifts of the RSNs...
April 2, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29606906/small-supernumerary-marker-chromosome-may-provide-information-on-dosage-insensitive-pericentric-regions-in-human
#6
Ahmed B Hamid Al-Rikabi, Sona Pekova, Xioabo Fan, Tereza Jančušková, Thomas Liehr
Background: Cytogenetically visible chromosomal imbalances in humans are deleterious and adverse in the majority of the cases. However, healthy persons living with chromosomal imbalances in the range of several megabasepairs (Mbps) in size, like carriers of small Supernumerary Marker Chromosomes (sSMCs) exist. Materials & Methods: The identification of healthy sSMC carriers with euchromatic centromere-near (ECN) imbalances led to the following proposal: ECN-regions do not contain any dosage sensitive genes...
April 2018: Current Genomics
https://www.readbyqxmd.com/read/29606606/gender-specific-effect-of-uric-acid-on-resting-state-functional-networks-in-de-novo-parkinson-s-disease
#7
Yoonju Lee, Yeong-Hun Park, Jae Jung Lee, Young H Sohn, Jong-Min Lee, Phil Hyu Lee
INTRODUCTION: The pattern of resting-state networks is influenced by several factors besides the underlying pathological changes of Parkinson's disease (PD). Uric acid (UA), as an antioxidant, has a neuroprotective property against PD-related microenvironment; however, this effect would be gender-specific. We aimed to evaluate a gender-sensitive resting-state networks (RSN) according to the UA level in drug naïve de novo patients with PD to elucidate the role of antioxidant in cortical functional networks of PD...
March 26, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29580768/functional-connectivity-between-anterior-insula-and-key-nodes-of-frontoparietal-executive-control-and-salience-networks-distinguish-bipolar-depression-from-unipolar-depression-and-healthy-control-subjects
#8
Kristen K Ellard, Jared P Zimmerman, Navneet Kaur, Koene R A Van Dijk, Joshua L Roffman, Andrew A Nierenberg, Darin D Dougherty, Thilo Deckersbach, Joan A Camprodon
BACKGROUND: Patients with bipolar depression are characterized by dysregulation across the full spectrum of mood, differentiating them from patients with unipolar depression. The ability to switch neural resources among the default mode network, salience network, and executive control network (ECN) has been proposed as a key mechanism for adaptive mood regulation. The anterior insula is implicated in the modulation of functional network switching. Differential connectivity between anterior insula and functional networks may provide insights into pathophysiological differences between bipolar and unipolar mood disorders, with implications for diagnosis and treatment...
February 7, 2018: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/29563542/probiotic-escherichia-coli-inhibits-biofilm-formation-of-pathogenic-e-coli-via-extracellular-activity-of-degp
#9
Kuili Fang, Xing Jin, Seok Hoon Hong
Many chronic infections involve bacterial biofilms, which are difficult to eliminate using conventional antibiotic treatments. Biofilm formation is a result of dynamic intra- or inter-species interactions. However, the nature of molecular interactions between bacteria in multi-species biofilms are not well understood compared to those in single-species biofilms. This study investigated the ability of probiotic Escherichia coli Nissle 1917 (EcN) to outcompete the biofilm formation of pathogens including enterohemorrhagic E...
March 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29556350/-e-coli-nissle-1917-derived-minicells-for-targeted-delivery-of-chemotherapeutic-drug-to-hypoxic-regions-for-cancer-therapy
#10
Yunlei Zhang, Wei Ji, Lian He, Yiyan Chen, Xuezhi Ding, Yunjun Sun, Shengbiao Hu, Huijun Yang, Weitao Huang, Youming Zhang, Fei Liu, Liqiu Xia
Purpose: Systemic administration of free chemotherapeutic drugs leads to severe toxic effects, and physiological characteristics of solid tumors restrain the drugs from reaching the hypoxic regions. E. coli Nissle 1917 (EcN) has been known to penetrate the barrier and proliferate in the interface between the viable and necrotic regions of tumors. This study aimed to fabricate a nanoscale minicell via genetic engineering of EcN for targeted delivery of chemotherapeutic drugs to the hypoxic regions of tumors for cancer therapy...
2018: Theranostics
https://www.readbyqxmd.com/read/29541538/transcranial-dc-stimulation-modifies-functional-connectivity-of-large-scale-brain-networks-in-abstinent-methamphetamine-users
#11
Alireza Shahbabaie, Mitra Ebrahimpoor, Ali Hariri, Michael A Nitsche, Javad Hatami, Emad Fatemizadeh, Mohammad Ali Oghabian, Hamed Ekhtiari
Background: Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation tool suited to alter cortical excitability and activity via the application of weak direct electrical currents. An increasing number of studies in the addiction literature suggests that tDCS modulates subjective self-reported craving through stimulation of dorsolateral prefrontal cortex (DLPFC). The major goal of this study was to explore effects of bilateral DLPFC stimulation on resting state networks (RSNs) in association with drug craving modulation...
March 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29521115/enhanced-antiproliferative-efficacy-of-epothilone-b-loaded-with-escherichia-coli-nissle-1917-bacterial-ghosts-on-the-hela-cells-by-mitochondrial-pathway-of-apoptosis
#12
Wenxing Zhu, Lujiang Hao, Xinli Liu, Borrás-Hidalgo Orlando, Yuyu Zhang
Epothilones constitute a new class of microtubule-stabilizing anticancer agents with promising preclinical and clinical activity. However, its systemic application still causes some toxic side effects. To reduce these undesired effects, advanced drug delivery systems based on cell targeting carriers are needed currently. In this study, the high quality bacterial ghosts of the probiotic Escherichia coli Nissle 1917 (EcN) were prepared in a large scale and retained fully intact surface structures for specific attachment to mammalian cells...
March 9, 2018: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29520911/functional-segregation-loss-over-time-is-moderated-by-apoe-genotype-in-healthy-elderly
#13
Kwun Kei Ng, Yingwei Qiu, June Chi-Yan Lo, Evelyn Siew-Chuan Koay, Woon-Puay Koh, Michael Wei-Liang Chee, Juan Zhou
We investigated the influence of the apolipoprotein E-ɛ4 allele (APOE-ɛ4) on longitudinal age-related changes in brain functional connectivity (FC) and cognition, in view of mixed cross-sectional findings. One hundred and twenty-two healthy older adults (aged 58-79; 25 APOE-ɛ4 carriers) underwent task-free fMRI scans at baseline. Seventy-eight (16 carriers) had at least one follow-up (every 2 years). Changes in intra- and internetwork FCs among the default mode (DMN), executive control (ECN), and salience (SN) networks, as well as cognition, were quantified using linear mixed models...
March 8, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29517685/the-altered-granger-causality-connection-among-pain-related-brain-networks-in-migraine
#14
Yanzhe Ning, Ruwen Zheng, Kuangshi Li, Yong Zhang, Diyang Lyu, Hongxiao Jia, Yi Ren, Yihuai Zou
Numerous fMRI studies have confirmed functional abnormalities in resting-state brain networks in migraine patients. However, few studies focusing on causal relationships of pain-related brain networks in migraine have been conducted. This study aims to explore the difference of Granger causality connection among pain-related brain networks in migraine without aura (MWoA) patients.Twenty two MWoA patients and 17 matched healthy subjects were recruited to undergo resting-state fMRI scanning. Independent component analysis was used to extract pain-related brain networks, and Granger causality analysis to characterize the difference of Granger causality connection among pain-related brain networks was employed...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29516157/phenological-changes-of-the-most-commonly-sampled-ground-beetle-coleoptera-carabidae-species-in-the-uk-environmental-change-network
#15
Gabor Pozsgai, John Baird, Nick A Littlewood, Robin J Pakeman, Mark R Young
Despite the important roles ground beetles (Coleoptera: Carabidae) play in ecosystems, the highly valued ecosystem services they provide, and ample descriptive documentation of their phenology, the relative impact of various environmental factors on carabid phenology is not well studied. Using the long-term pitfall trap capture data from 12 terrestrial Environmental Change Network (ECN) sites from the UK, we examined how changing climate influenced the phenology of common carabids, and the role particular climate components had on phenological parameters...
March 7, 2018: International Journal of Biometeorology
https://www.readbyqxmd.com/read/29502442/abstracts-of-the-basic-and-clinical-multimodal-imaging-baci-conference-annual-joint-meeting-of-ecns-isbet-isfsi-and-isnip-bern-switzerland-august-29-september-2-2017
#16
(no author information available yet)
No abstract text is available yet for this article.
March 1, 2018: Clinical EEG and Neuroscience: Official Journal of the EEG and Clinical Neuroscience Society (ENCS)
https://www.readbyqxmd.com/read/29477840/one-way-traffic-the-inferior-frontal-gyrus-controls-brain-activation-in-the-middle-temporal-gyrus-and-inferior-parietal-lobule-during-divergent-thinking
#17
Oshin Vartanian, Erin L Beatty, Ingrid Smith, Kristen Blackler, Quan Lam, Sarah Forbes
Contrary to earlier approaches that focused on the contributions of isolated brain regions to the emergence of creativity, there is now growing consensus that creative thought emerges from the interaction of multiple brain regions, often embedded within larger brain networks. Specifically, recent evidence from studies of divergent thinking suggests that kernel ideas emerge in posterior brain regions residing within the semantic system and/or the default mode network (DMN), and that the prefrontal cortex (PFC) regions within the executive control network (ECN) constrain those ideas for generating outputs that meet task demands...
February 22, 2018: Neuropsychologia
https://www.readbyqxmd.com/read/29475172/brain-network-alteration-in-patients-with-temporal-lobe-epilepsy-with-cognitive-impairment
#18
Hongyu Yang, Chao Zhang, Chang Liu, Tao Yu, Guojun Zhang, Nan Chen, Kuncheng Li
The aims of this study were to investigate the brain network alternation in patients with temporal lobe epilepsy (TLE) with and without cognitive impairment (CI) using functional magnetic resonance imaging (fMRI) and to further explore the potential mechanisms of epilepsy-induced CI. Forty patients with TLE and nineteen healthy controls (HCs) were recruited for this study. All participants received the Montreal Cognitive Assessment (MoCA) test, and the patients were divided into CI (n=21) and cognitive nonimpairment (CNI) groups (n=19) according to MoCA performance...
February 20, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29445138/non-toxic-engineered-carbon-nanodiamond-concentrations-induce-oxidative-nitrosative-stress-imbalance-of-energy-metabolism-and-mitochondrial-dysfunction-in-microglial-and-alveolar-basal-epithelial-cells
#19
Claudia G Fresta, Aishik Chakraborty, Manjula B Wijesinghe, Angela M Amorini, Giacomo Lazzarino, Giuseppe Lazzarino, Barbara Tavazzi, Susan M Lunte, Filippo Caraci, Prajnaparamita Dhar, Giuseppe Caruso
Engineered nanoparticles are finding a wide spectrum of biomedical applications, including drug delivery and capacity to trigger cytotoxic phenomena, potentially useful against tumor cells. The full understanding of their biosafety and interactions with cell processes is mandatory. Using microglial (BV-2) and alveolar basal epithelial (A549) cells, in this study we determined the effects of engineered carbon nanodiamonds (ECNs) on cell viability, nitric oxide (NO) and reactive oxygen species (ROS) production, as well as on energy metabolism...
February 14, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29422882/disrupted-brain-intrinsic-networks-and-executive-dysfunction-in-cirrhotic-patients-without-overt-hepatic-encephalopathy
#20
Zhe-Ting Yang, Hua-Jun Chen, Qiu-Feng Chen, Hailong Lin
Objective: Patients with cirrhosis often exhibit cognitive deficits, particularly executive dysfunction, which is considered a predictor of overt hepatic encephalopathy (OHE). We examined brain intrinsic networks associated with executive function to investigate the neural basis of this cognitive deficiency in cirrhosis. Methods: Resting-state functional MRI data were acquired from 20 cirrhotic patients and 18 healthy controls. Seed-based correlation analysis was used to identify the three well-known networks associated with executive function, including executive control (ECN), default mode (DMN), and salience (SN) networks...
2018: Frontiers in Neurology
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