Shuangwei Hong, Longhao Chen, Xingchen Zhou, Yuanshen Huang, Yu Tian, Huijie Hu, Bei Yu, Hongjiao Wu, Chao Yang, Zhizhen Lv, Lijiang Lv
BACKGROUND: Observational studies have hinted at a correlation between the gut microbiota and spinal pain (SP). However, the impact of the gut microbiota on SP remains inconclusive. METHODS: In this study, we employed a two-sample Mendelian randomization (MR) analysis to explore the causal relationship between the gut microbiota and SP, encompassing neck pain (NP), thoracic spine pain (TSP), low back pain (LBP), and back pain (BP). The compiled gut microbiota data originated from a genome-wide association study (GWAS) conducted by the MiBioGen consortium ( n = 18,340)...
2024: Frontiers in Microbiology