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https://www.readbyqxmd.com/read/29656629/differences-in-cervical-sagittal-alignment-changes-in-patients-undergoing-laminoplasty-and-anterior-cervical-discectomy-and-fusion
#1
Su Hun Lee, Dong Wuk Son, Jun Seok Lee, Dong Ha Kim, Soon Ki Sung, Sang Weon Lee, Geun Sung Song
OBJECTIVE: Anterior cervical discectomy and fusion (ACDF) and laminoplasty (LP) are the most commonly performed procedures for degenerative cervical spondylosis. Cervical sagittal alignment (CSA) has recently been studied as an important predictor of clinical and radiological outcomes. The data from previous studies are insufficient for analysis using the recently designed CSA parameters, T1 slope (T1s), and T1s minus cervical angle (T1sCA). METHODS: We retrospectively collected data from patients who underwent ACDF and LP from January 2013 to May 2016...
March 2018: Neurospine
https://www.readbyqxmd.com/read/29656628/cerebral-thromboembolic-events-during-anterior-cervical-spine-surgery-retrospective-case-series-study-with-diffusion-weighted-magnetic-resonance-imaging-follow-up-in-the-immediate-postoperative-period
#2
Seok-Won Chung, Min-Soo Kang, Sang-Ho Lee, Shin-Young Lee, Yong-Hwan Shin, Chan-Hong Park
OBJECTIVE: We evaluated the efficacy of diffusion-weighted magnetic resonance imaging (DW-MRI) in detecting perioperative cerebral thromboembolic events after anterior cervical discectomy and fusion (ACDF). METHODS: This retrospective case series included 51 consecutive patients that underwent ACDF. To assess baseline presence of plaque or stenosis, all patients were assessed for risk factors of cerebrovascular events and underwent carotid ultrasound preoperatively and cerebral DW-MRI was performed in all patients postoperatively, with areas of high signal intensity interpreted as a cerebral thromboembolic event...
March 2018: Neurospine
https://www.readbyqxmd.com/read/29656627/ossification-of-the-posterior-longitudinal-ligament-in-cervical-spine-prevalence-management-and-prognosis
#3
REVIEW
Jau-Ching Wu, Yu-Chun Chen, Wen-Cheng Huang
Ossification of the posterior longitudinal ligament (OPLL) in the cervical spine and related neurological complications are not uncommon in East Asian countries. The estimated prevalence of cervical OPLL-related hospitalization is 7.7 per 100,000 person-years in Taiwan, and higher incidence rates have been observed in elderly and male patients. Although cervical OPLL is frequently insidious, it can eventually cause myelopathy and predispose patients to spinal cord injury (SCI). There are multiple options for managing cervical OPLL, ranging from observation to many kinds of surgical procedures, including posterior laminoplasty, laminectomy with or without fusion, anterior corpectomy with or without instrumentation, and circumferential decompression and fusion...
March 2018: Neurospine
https://www.readbyqxmd.com/read/29656556/melt-electrowriting-of-thermoplastic-elastomers
#4
Gernot Hochleitner, Eva Fürsattel, Reiner Giesa, Jürgen Groll, Hans-Werner Schmidt, Paul D Dalton
Melt electrowriting (MEW), an additive manufacturing process, is established using polycaprolactone as the benchmark material. In this study, a thermoplastic elastomer, namely, poly(urea-siloxane), is synthesized and characterized to identify how different classes of polymers are compatible with MEW. This polyaddition polymer has reversible hydrogen bonding from the melt upon heating/cooling and highly resolved structures are achieved by MEW. The influence of applied voltage, temperature, and feeding pressure on printing outcomes behavior is optimized...
April 14, 2018: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/29656519/character-evolution-and-missing-morphological-data-across-asteridae
#5
Gregory W Stull, Melanie Schori, Douglas E Soltis, Pamela S Soltis
PREMISE OF THE STUDY: Our current understanding of flowering plant phylogeny provides an excellent framework for exploring various aspects of character evolution through comparative analyses. However, attempts to synthesize this phylogenetic framework with extensive morphological data sets have been surprisingly rare. Here, we explore character evolution in Asteridae (asterids), a major angiosperm clade, using an extensive morphological data set and a well-resolved phylogeny. METHODS: We scored 15 phenotypic characters (spanning chemistry, vegetative anatomy, and floral, fruit, and seed features) across 248 species for ancestral state reconstruction using a phylogenetic framework based on 73 plastid genes and the same 248 species...
April 14, 2018: American Journal of Botany
https://www.readbyqxmd.com/read/29656282/intrapopulation-chromosomal-polymorphism-in-mazama-gouazoubira-cetartiodactyla-cervidae-the-emergence-of-a-new-species
#6
Mirela P Valeri, Iara M Tomazella, José M B Duarte
Mazama gouazoubira is a small deer species widely distributed in South America. Previous studies have shown that this species presents intraspecific chromosomal polymorphisms, which could affect fertility due to the effects of chromosomal rearrangements on gamete formation. Important aspects regarding the karyotype evolution of this species and the genus remain undefined due to the lack of information concerning the causes of this chromosomal variation. Nineteen individuals belonging to the Mazama gouazoubira population located in the Pantanal were cytogenetically evaluated...
April 14, 2018: Cytogenetic and Genome Research
https://www.readbyqxmd.com/read/29656174/multiplanar-realignment-for-unstable-hangman-s-fracture-with-posterior-c2-3-fusion-a-prospective-series
#7
Pravin Salunke, Madhivanan Karthigeyan, Sushanta K Sahoo, Prashant K Prasad
OBJECTIVE: There is lack of consensus on the preferred approach for unstable Hangman's fracture. The associated soft tissue injuries apart from apparent bony injury add to the complexity of dislocation and needs to be addressed. Here, we evaluated the clinico-radiological characteristics and outcome of patients managed by posterior C2-3 fusion. PATIENTS & METHODS: Nine patients with unstable Hangman's fracture (type II and IIA) were prospectively studied. The displacement of fractured fragments and C2-3 dislocation was studied in multiple planes...
March 27, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29656173/factors-associated-with-extension-of-the-scheduled-time-for-spine-surgery
#8
Kazuyoshi Kobayashi, Kei Ando, Kenyu Ito, Mikito Tsushima, Masayoshi Morozumi, Satoshi Tanaka, Masaaki Machino, Kyotaro Ota, Naoki Ishiguro, Shiro Imagama
OBJECTIVES: Adherence to scheduled times in surgery is important in hospital management. However, sudden surgical changes or unexpected intraoperative problems may lead to prolongation of operative times. The purpose of this study was to investigate operative times in spinal surgery and to identify causes of delays during surgery. PATIENTS AND METHODS: A retrospective review of 488 cases of spinal surgery was performed to investigate operations prolonged for >2 h and to identify factors associated with prolongation...
April 3, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29655650/surgical-treatment-of-lisfranc-injury-with-plantar-plate-approach
#9
Deepal Dalal, Christian Curry, Ryan Carter, Colin Zdenek, Nicholas W Todd, Shannon M Rush, Richard Jensen
Midfoot injuries are the second most common athletic foot injury documented in the published data. High-energy Lisfranc dislocations are commonly seen secondary to traumatic etiologies and disrupt the strong midfoot ligaments supporting the arch. These injuries require immediate surgical intervention to prevent serious complications such as compartment syndrome and amputation. The present case series reports a new Lapidus plate system used in 3 patients who underwent arthrodesis procedures for Lisfranc joint dislocation...
April 11, 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29655516/plga-%C3%AE-tcp-composite-scaffold-incorporating-salvianolic-acid-b-promotes-bone-fusion-by-angiogenesis-and-osteogenesis-in-a-rat-spinal-fusion-model
#10
Sien Lin, Liao Cui, Guanghua Chen, Jianping Huang, Yanhua Yang, Kaijie Zou, Yuxiao Lai, Xinluan Wang, Liyi Zou, Tie Wu, Jack Chun Yiu Cheng, Gang Li, Bo Wei, Wayne Yuk Wai Lee
Spinal disorders often require surgical treatment called spinal fusion to restore a stabilized spine where bone grafts are implanted for the fusion of adjacent vertebras. In this study, we developed a bioactive composite scaffold incorporated with salvianolic acid B (SB), an active component extracted from Danshen. This study aimed to evaluate the effects of SB-incorporated porous scaffold on spinal fusion models. The composite scaffolds composed of poly (lactic-co-glycolic acid) and tricalcium phosphate (PLGA/β-TCP) were fabricated with low-temperature rapid prototyping technique, which incorporated SB at low (SB-L), middle (SB-M), high (SB-H) doses, and pure PLGA/β-TCP as blank control (Con)...
April 4, 2018: Biomaterials
https://www.readbyqxmd.com/read/29653294/sclerostin-vaccination-mitigates-estrogen-deficiency-induction-of-bone-mass-loss-and-microstructure-deterioration
#11
Feng-Sheng Wang, Re-Wen Wu, Wei-Shiung Lain, Tsai-Chen Tsai, Yu-Shan Chen, Yi-Chih Sun, Huei-Jing Ke, Jui-Chen Li, Jau-Lang Hwang, Jih-Yang Ko
Sclerostin (SOST) is a Wnt signaling inhibitor detrimental to osteogenic differentiation and bone mineral acquisition. While control of SOST action delays the pathogenesis of skeletal disorders, the effects of SOST vaccination on the estrogen deficiency-induced bone deterioration remain elusive. In this study, we generated a SOST-Fc fusion protein which was composed of a SOST peptide Pro-Asn-Ala-Ile-Gly along with an IgG Fc fragment. SOST-Fc vaccination increased serum anti-SOST antibody levels and reduced serum SOST concentrations in mice...
April 10, 2018: Bone
https://www.readbyqxmd.com/read/29653271/risk-factors-additional-length-of-stay-and-cost-associated-with-postoperative-ileus-following-anterior-lumbar-interbody-fusion-in-the-elderly
#12
Jason A Horowitz, Amit Jain, Varun Puvanesarajah, Rabia Qureshi, Hamid Hassanzadeh
OBJECTIVE: Identify the independent risk factors, additional length of stay, and additional cost associated with postoperative ileus following anterior lumbar interbody fusion in the elderly. METHODS: The PearlDiver Patient Records Database (Young & Ellison, LLC, Colorado Springs, CO) was queried for all Medicare patients 65 years of age and older undergoing 1 or 2 level primary elective anterior lumbar interbody fusion from 2005-2014. Independent risk factors, additional length of stay, and additional cost associated with postoperative ileus were evaluated with multivariate analysis...
April 10, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29653244/opioid-utilization-following-cervical-spine-surgery-trends-and-factors-associated-with-long-term-use
#13
Andrew J Pugely, Nicholas A Bedard, Piyush Kalakoti, Nathan R Hendrickson, Jamal N Shillingford, Joseph L Laratta, Comron Saifi, Ronald A Lehman, K Daniel Riew
BACKGROUND CONTEXT: Limited or no data exist evaluating risk-factors associated with prolonged opioid use following cervical arthrodesis. PURPOSE: To assess trends in post-operative narcotic use amongst preoperative opioid users (OU) versus non-opioid users (NOU), and identify factors associated with postoperative narcotic use at 1-year following cervical arthrodesis. STUDY DESIGN/SETTING: Retrospective, observational study. PATIENT SAMPLE: 17,391 patients (OU: 52...
April 10, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29653121/integration-and-diagnostic-accuracy-of-3t-non-endorectal-coil-prostate-mri-in-the-context-of-active-surveillance
#14
Nicole E Curci, Brian R Lane, Prasad R Shankar, Sabrina L Noyes, Andrew K Moriarty, Anthony Kubat, Chris Brede, Jeffrey S Montgomery, Gregory B Auffenberg, David C Miller, James E Montie, Arvin K George, Matthew S Davenport
OBJECTIVE: To evaluate the integration of 3T non-endorectal-coil multiparametric prostate MRI (mpMRI) at two high-volume practices that routinely use mpMRI in the setting of active surveillance. MATERIALS AND METHODS: This was an IRB-approved, HIPAA-compliant, dual-institution retrospective cohort study. Subjects undergoing 3T mpMRI without endorectal coil at either study institution over a 13-month period (8/1/2015-8/31/2016) were selected based on pre-defined criteria: clinical T1/T2 Gleason 6 prostate cancer, PSA<15 ng/mL, ≥40 years-old, mpMRI within 2 years of prostate biopsy, PI-RADS v2 score assigned...
April 10, 2018: Urology
https://www.readbyqxmd.com/read/29653010/-transformation-from-promyelocytic-leukemia-with-t-15-17-q22-q21-to-acute-monocytic-leukemia-with-t-11-17-q23-q21-in-a-case
#15
Zheng Wang, Ye Li, Hui Dang, Yan Shi, Qi He, Lin Feng, Li Bao, Yazhen Qin, Yanrong Liu, Xiaojun Huang, Yueyun Lai
OBJECTIVE: To report on a case of therapy-related acute monocytic leukemia(t-AML) with t(11;17) (q23;q21)/MLL-AF17q after successful treatment for acute promyelocytic leukemia(APL) with t(15;17) (q22;q21)/PML-RARα. METHODS: A MICM method (bone marrow morphology(M), immunophenotype(I), cytogenetics(C), and molecular biology(M)) was used for the diagnosis and classification of the disease at the time of onset and transformation. RESULTS: The patient was initially identified with typical morphology and immunophenotype of APL...
April 10, 2018: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
https://www.readbyqxmd.com/read/29652862/inhibitory-effects-of-human-primary-intervertebral-disc-cells-on-human-primary-osteoblasts-in-a-co-culture-system
#16
Rahel D May, Daniela A Frauchiger, Christoph E Albers, Lorin M Benneker, Sandro Kohl, Benjamin Gantenbein
Spinal fusion is a common surgical procedure to address a range of spinal pathologies, like damaged or degenerated discs. After the removal of the intervertebral disc (IVD), a structural spacer is positioned followed by internal fixation, and fusion of the degenerated segment by natural bone growth. Due to their osteoinductive properties, bone morphogenetic proteins (BMP) are applied to promote spinal fusion. Although spinal fusion is successful in most patients, the rates of non-unions after lumbar spine fusion range from 5% to 35%...
April 13, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29652786/long-term-results-of-surgery-compared-with-nonoperative-treatment-for-lumbar-degenerative-spondylolisthesis-in-the-spine-patient-outcomes-research-trial-sport
#17
William A Abdu, Olivia A Sacks, Anna N A Tosteson, Wenyan Zhao, Tor D Tosteson, Tamara S Morgan, Adam Pearson, James N Weinstein, Jon D Lurie
STUDY DESIGN: Randomized trial with a concurrent observational cohort study OBJECTIVE.: To compare eight-year outcomes between surgery and nonoperative care and among different fusion techniques for symptomatic lumbar degenerative spondylolisthesis (DS). SUMMARY OF BACKGROUND DATA: Surgical treatment of DS has been shown to be more effective than nonoperative treatment out to four years. This study sought to further determine the long-term (8-year) outcomes. METHODS: Surgical candidates with DS from thirteen centers with at least twelve weeks of symptoms and confirmatory imaging were offered enrollment in a randomized controlled trial (RCT) or observational cohort study (OBS)...
April 12, 2018: Spine
https://www.readbyqxmd.com/read/29652784/a-prospective-randomized-multicenter-study-comparing-silicated-calcium-phosphate-versus-bmp-2-synthetic-bone-graft-in-posterolateral-instrumented-lumbar-fusion-for-degenerative-spinal-disorders
#18
Marc Coughlan, Mark Davies, Adriaan K Mostert, Dharmin Nanda, Paul C Willems, Geoffrey Rosenberg, Richard Ferch
STUDY DESIGN: A prospective, Phase IV, multicenter, randomized study. OBJECTIVE: To compare vertebral fusion success rates following posterolateral fusion ((PLF)/posterolateral intertransverse fusion (PITF)) surgery. The surgical procedure combined posterior lumbar interbody fusion (PLIF) and PLF with internal fixation over one or two levels using silicated calcium phosphate (SiCaP) or bone morphogenetic protein (BMP)-2 as graft material in patients with a degenerative disorder of the lumbar spine...
April 12, 2018: Spine
https://www.readbyqxmd.com/read/29652747/the-incremental-clinical-value-of-cardiac-hybrid-spect-cta-imaging-in-coronary-artery-disease
#19
Lin Qiu, Hui Tan, Dengfeng Cheng, Hongcheng Shi
Coronary artery disease (CAD) is a major cause of death worldwide. It is significantly important to assess the coronary lesion and its pathophysiological relevance comprehensively. Coronary computed tomography angiography (CTA) or myocardial perfusion imaging alone suffers from some limitations in the evaluation of CAD. Through the integration and spatial colocalization of complementary morphological and functional information, the results of published hybrid single-photon emission computed tomography (SPECT)/CTA studies in patients with CAD are promising for detecting functionally relevant coronary artery lesion and evaluating the relationship between diseased coronary artery, coronary artery anomaly, myocardial bridging, or coronary calcification and myocardial ischemia...
April 12, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29652537/subphenotyping-and-classification-of-cleft-lip-and-alveolus-in-adult-unoperated-patients-a-new-embryological-approach
#20
Christl Vermeij-Keers, Anna M Rozendaal, Antonius J M Luijsterburg, Benny S Latief, Costas Lekkas, Lea Kragt, Edwin M Ongkosuwito
OBJECTIVE: Previously, a new embryological classification was introduced subdividing oral clefts into fusion and/or differentiation defects. This subdivision was used to classify all subphenotypes of cleft lip with or without alveolus (CL±A). Subsequently, it was investigated whether further morphological grading of incomplete CLs is clinically relevant, and which alveolar part is deficient in fusion/differentiation defects. DESIGN: Observational cohort study. SETTING: Three hundred fifty adult unoperated Indonesian cleft patients presented themselves for operation...
January 1, 2018: Cleft Palate-craniofacial Journal
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