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https://www.readbyqxmd.com/read/29458172/modelling-human-myoblasts-survival-upon-xenotransplantation-into-immunodeficient-mouse-muscle
#1
Christophe Praud, Karine Vauchez, Pascal Zongo, Jean-Thomas Vilquin
Cell transplantation has been challenged in several clinical indications of genetic or acquired muscular diseases, but therapeutic success were mitigated. To understand and improve the yields of tissue regeneration, we aimed at modelling the fate of CD56-positive human myoblasts after transplantation. Using immunodeficient severe combined immunodeficiency (SCID) mice as recipients, we assessed the survival, integration and satellite cell niche occupancy of human myoblasts by a triple immunohistochemical labelling of laminin, dystrophin and human lamin A/C...
February 16, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29458048/4-phenylbutyric-acid-protects-against-lipopolysaccharide-induced-bone-loss-by-modulating-autophagy-in-osteoclasts
#2
Hyun-Jung Park, Ho-Jung Son, Ok-Joo Sul, Jae-Hee Suh, Hye-Seon Choi
4-Phenylbutyric acid (4-PBA) has been used clinically to treat urea cycle disorders and is known to be an inhibitor of endoplasmic reticulum (ER) stress. We hypothesized that 4-PBA attenuates inflammatory bone loss by inducing autophagy, a process that is frequently accompanied by ER stress. Micro computerized tomography analysis showed that 4-PBA attenuated LPS-induced bone loss in mice. The increased area of TRAP-positive osteoclasts (OCs) and serum level of collagen type I fragments in lipopolysaccharide (LPS)-treated mice were also decreased when 4-PBA was administered, suggesting a protective role of 4-PBA in OCs...
February 16, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29458023/structural-characterization-of-the-hcov-229e-fusion-core
#3
Wei Zhang, Qianqian Zheng, Mengrong Yan, Xiaobo Chen, Haitao Yang, Weihong Zhou, Zihe Rao
HCoV-229E spike (S) protein mediates virion attachment to cells and subsequent fusion of the viral and cellular membranes. This protein is composed of an N-terminal receptor-binding domain (S1) and a C-terminal trans-membrane fusion domain (S2). S2 contains a highly conserved heptad repeat 1 and 2 (HR1 and HR2). In this study, the HRs sequences were designed and connected with a flexible linker. The recombinant fusion core protein was crystallized and its structure was solved at a resolution of 2.45 Å. Then we characterized the binding of HR1s and HR2s via both sequence alignment and structural analysis...
February 16, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29457900/three-dimensional-structures-based-on-the-fusion-of-chrysene-and-spirobifluorene-chromophores-for-the-development-of-blue-oleds
#4
Hayoon Lee, Hyocheol Jung, Seokwoo Kang, Jin Hyuck Heo, Sang Hyuk Im, Jongwook Park
A new deep-blue chromophore containing a three-dimensionally (3D) shaped CS core composed of fused chrysene and spirofluorene units is synthesized. A pair of m-terphenyl (TP) units is also substituted onto the CS core, at two different sets of positions to form two additional compounds: CS-TPTP and TP-CS-TP. The TP-CS-TP compound showed the highest efficiency with an external quantum efficiency (EQE) of 3.05%, and Commission Internationale de L'Eclairage coordinates (CIE) of (0.148, 0.098) corresponding to the emission of blue light...
February 19, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29457442/-development-and-application-of-artificial-vertebral-body
#5
REVIEW
Jian-Tao Liu, Feng Zhang, Zheng-Chao Gao, Bin-Bin Niu, Yu-Huan Li, Xi-Jing He
Artificial vertebral body has achieved good results in treating spinal tumors, tuberculosis, fracture and other diseases. Currently, artificial vertebral body with variety of kinds and pros and cons, is generally divided into two types: fusion type and movable type. The former according to whether the height could be adjusted and strength of self-stability is divided into three types: support-fixed type, adjust-fixed type and self-fixed type. Whether the height of self-fixed type could be adjusted is dependent on structure of collar thread rotation...
December 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29457388/-case-control-study-of-therapeutic-effects-between-extreme-lateral-interbody-fusion-and-conventional-posterior-operation-for-the-treatment-of-upper-lumbar-disc-herniation
#6
Can-Hua Xu, Zeng-Hui Wu, Rong-Chun Chen, Hong-Fa Zhong, Qing-Shun Zhang, Ning Liu, Bi Zhang
OBJECTIVE: To evaluate the clinical outcomes between extreme lateral interbody fusion and conventional posterior operation in the treatment of upper lumbar disc herniation. METHODS: Among 60 patients with upper lumbar disc herniation were treated with extreme lateral interbody fusion(XLIF) or conventional posterior operation from June 2010 to December 2014, 30 patients(19 males and 11 females) were treated with XLIF (XLIF group); and the other 30 patients(17 males and 13 females) were treated with conventional posterior operation (conventional group)...
November 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29457021/difficult-renal-pathological-classification-in-a-case-of-pediatric-nephrotic-syndrome
#7
Hiroshi Yamaguchi, Atsutoshi Shiratori, Taku Nakagawa, Kyoko Kanda, Shigeo Hara, Norishige Yoshikawa, Ryojiro Tanaka
The underlying histopathology is very important in determining patient management, as the histopathology usually has direct repercussions on the treatment response and clinical course. However, the impact of the method used to assess renal biopsies, i.e., light microscopy (LM), immunofluorescence (IF), and electron microscopy (EM), on the occurrence of a difficult biopsy classification in the native kidneys of pediatric nephrotic patients is unknown. A 12-month-old Japanese boy was diagnosed with nephrotic syndrome (NS); he was administered prednisolone (60 mg/m2 /day), and a continuous albumin infusion was started...
September 2017: Case Reports in Nephrology and Dialysis
https://www.readbyqxmd.com/read/29456988/effect-of-twine-arginine-translocation-signaling-fusion-system-and-chaperones-co-expression-on-secretory-expression-of-somatropin
#8
Mohammad Reza Bagherinejad, Hamid Mir-Mohammad Sadeghi, Daryoush Abedi, Fateme Moazen, Mohammad Rabbani
Background: Twine-arginine translocation (TAT) system is one of the exporting systems in Escherichia coli which could transport fully/semi-correctly folded proteins outside the reductive cytoplasmic space. In combination with co-expression with a chaperone system, the correctly folded proteins could be transported to oxidative periplasmic space and culture media to pass the main limitations in E. coli expression system such as misfolding and inclusion body formation. Materials and Methods: To study the effectiveness of signaling sequences and chaperone co-expression on the translocation of expressed protein, somatropin was selected as the target...
2018: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29456920/evidence-based-analysis-of-adjacent-segment-degeneration-and-disease-after-lif-a-narrative-review
#9
Nikunj N Trivedi, Sean M Wilson, Luis A Puchi, Darren R Lebl
Study Design: Narrative review. Objectives: The etiology of adjacent segment degeneration (ASDeg) and adjacent segment disease (ASDz) after lumbar interbody fusion (LIF) remains controversial. The aim of this narrative review was to provide an evidence-based analysis of the peer-reviewed literature on clinical studies of ASDeg and ASDz after LIF. Methods: A review was performed utilizing Medline, Embase, and Cochrane databases. Two reviewers independently extracted relevant data from each included study...
February 2018: Global Spine Journal
https://www.readbyqxmd.com/read/29456918/cervical-disc-arthroplasty-a-comprehensive-review-of-single-level-multilevel-and-hybrid-procedures
#10
REVIEW
Joseph L Laratta, Jamal N Shillingford, Comron Saifi, K Daniel Riew
Study Design: Systematic review. Objectives: Degenerative disc disease and spondylosis resulting in radiculopathy and retrodiscal myelopathy are among the most frequently encountered cervical spinal disorders. Traditionally, anterior cervical discectomy and fusion (ACDF) has successfully achieved neural decompression and restored intradiscal height in these conditions. Unfortunately, nonunion and iatrogenic adjacent segment pathology associated with fusion procedures in the cervical spine has led to an interest in motion-preserving procedures...
February 2018: Global Spine Journal
https://www.readbyqxmd.com/read/29456916/spine-degenerative-conditions-and-their-treatments-national-trends-in-the-united-states-of-america
#11
Zorica Buser, Brandon Ortega, Anthony D'Oro, William Pannell, Jeremiah R Cohen, Justin Wang, Ray Golish, Michael Reed, Jeffrey C Wang
Study Design: Retrospective database study. Objective: Low back and neck pain are among the top leading causes of disability worldwide. The aim of our study was to report the current trends on spine degenerative disorders and their treatments. Methods: Patients diagnosed with lumbar or cervical spine conditions within the orthopedic subset of Medicare and Humana databases (PearlDiver). From the initial cohorts we identified subgroups based on the treatment: fusion or nonoperative within 1 year from diagnosis...
February 2018: Global Spine Journal
https://www.readbyqxmd.com/read/29456914/is-cervical-bracing-necessary-after-one-and-two-level-instrumented-anterior-cervical-discectomy-and-fusion-a-prospective-randomized-study
#12
Samuel C Overley, Robert K Merrill, Evan O Baird, Joshua J Meaike, Samuel K Cho, Andrew C Hecht, Sheeraz A Qureshi
Study Design: Prospective randomized control trial. Objective: To investigate the role of cervical collars in postoperative care following 1- and 2-level instrumented anterior cervical discectomy and fusion (ACDF). Methods: The Cervical Spine Research Society Resident Fellow Grant funded this project. Fifty consecutive patients undergoing 1- or 2-level ACDF surgery were randomized into groups receiving either no brace or a cervical brace for 6 weeks postoperatively...
February 2018: Global Spine Journal
https://www.readbyqxmd.com/read/29456913/investigating-the-7-year-cost-effectiveness-of-single-level-cervical-disc-replacement-compared-to-anterior-cervical-discectomy-and-fusion
#13
Steven J McAnany, Robert K Merrill, Samuel C Overley, Jun S Kim, Robert L Brochin, Sheeraz A Qureshi
Study Design: Cost-effectiveness analysis. Objectives: To determine the 7-year cost-effectiveness of cervical disc replacement (CDR) and anterior cervical discectomy and fusion (ACDF). Methods: We analyzed 7-year Short Form-36 Health Survey data collected from the Prestige Cervical Disc investigational device exemption study (IDE). The SF-6D algorithm was used to convert this data into health state utilities. Costs were calculated from the payer perspective, and quality adjusted life years (QALYs) were used to represent effectiveness...
February 2018: Global Spine Journal
https://www.readbyqxmd.com/read/29456912/dural-tears-in-adult-deformity-surgery-incidence-risk-factors-and-outcomes
#14
Sravisht Iyer, Eric O Klineberg, Lukas P Zebala, Michael P Kelly, Robert A Hart, Munish C Gupta, D Kojo Hamilton, Gregory M Mundis, Daniel Sciubba, Christopher P Ames, Justin S Smith, Virginie Lafage, Douglas Burton, Han Jo Kim
Study Design: Retrospective cohort study. Objectives: Describe the rate of dural tears (DTs) in adult spinal deformity (ASD) surgery. Describe the risk factors for DT and the impact of this complication on clinical outcomes. Methods: Patients with ASD undergoing surgery between 2008 and 2014 were separated into DT and non-DT cohorts; demographics, operative details, radiographic, and clinical outcomes were compared. Statistical analysis included t tests or χ2 tests as appropriate and a multivariate analysis...
February 2018: Global Spine Journal
https://www.readbyqxmd.com/read/29456910/comparing-the-incidence-of-index-level-fusion-following-minimally-invasive-versus-open-lumbar-microdiscectomy
#15
Steven J McAnany, Samuel C Overley, Muhammad A Anwar, Holt S Cutler, Javier Z Guzman, Jun S Kim, Robert K Merrill, Samuel K Cho, Andrew C Hecht, Sheeraz A Qureshi
Study Design: Retrospective cohort study. Objectives: To determine the incidence of index level fusion following open or minimally invasive lumbar microdiscectomy. Methods: We conducted a retrospective review of 174 patients with a symptomatic single-level lumbar herniated nucleus pulposus who underwent microdiscectomy via a mini-open approach (MIS; 39) or through a minimally invasive dilator tube (135). Outcomes of interest included revision microdiscectomy and the ultimate need for index level fusion...
February 2018: Global Spine Journal
https://www.readbyqxmd.com/read/29456909/comparing-the-5-year-health-state-utility-value-of-cervical-disc-replacement-and-anterior-cervical-discectomy-and-fusion
#16
Steven J McAnany, Robert K Merrill, Robert L Brochin, Samuel C Overley, Jun S Kim, Sheeraz A Qureshi
Study Design: Health utility analysis. Objectives: To determine the health state utility (HSU) of 1- and 2-level anterior cervical discectomy and fusion (ACDF) and cervical disc replacement (CDR). Methods: Data from the Medtronic Prestige Cervical Disc investigational device exemption studies was used. Four groups were defined: 1-level ACDF, 1-level CDR, 2-level ACDF, and 2-level CDR. The 36-item Short Form Health Survey (SF-36) was collected at baseline, 12 months, 24 months, 36 months, and 60 months postoperatively and converted into utility scores for each time point...
February 2018: Global Spine Journal
https://www.readbyqxmd.com/read/29456905/a-comprehensive-review-of-the-sternal-foramina-and-its-clinical-significance
#17
REVIEW
Paul J Choi, Joe Iwanaga, R Shane Tubbs
A sternal foramen (SF), which arises from the incomplete fusion of the cartilaginous neonatal sternum, is a relatively common anatomical variation found in 2.5% to 13.8 % of all individuals. SFs are usually located at the lower third of the sternal body and their average diameter is 6.5 mm. An SF is subclinical; however, its close proximity to the thoracic organs, i.e., the heart and lungs, entails a risk of serious complications from blinded sternal interventions. Moreover, its presence can lead to misinterpretation of radiological and postmortem findings...
December 8, 2017: Curēus
https://www.readbyqxmd.com/read/29456853/crizotinib-associated-toxic-epidermal-necrolysis-in-an-alk-positive-advanced-nsclc-patient
#18
Shaoyu Yang, Liming Wu, Xin Li, Jie Huang, Jianbo Zhong, Xueqin Chen
Crizotinib is an oral small-molecule inhibitor of anaplastic lymphoma kinase (ALK) tyrosine-kinase that has been approved for treating patients with advanced echinoderm microtubule associated protein like 4-ALK rearranged non-small-cell lung cancer (NSCLC). Toxic epidermal necrolysis (TEN) is a rare adverse event associated with crizotinib. The present study reported a case of a 75-year-old Chinese male patient with advanced NSCLC with ALK fusion, who developed TEN after 56 days of crizotinib treatment and demised due to this dermatological adverse event...
March 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29456794/discovery-of-3-3-spiro-azetidine-2-oxo-indoline-derivatives-as-fusion-inhibitors-for-treatment-of-rsv-infection
#19
Weihua Shi, Zhigan Jiang, Haiying He, Fubiao Xiao, Fusen Lin, Ya Sun, Lijuan Hou, Liang Shen, Lixia Han, Minggao Zeng, Kunmin Lai, Zhengxian Gu, Xinsheng Chen, Tao Zhao, Li Guo, Chun Yang, Jian Li, Shuhui Chen
A new series of 3,3'-spirocyclic-2-oxo-indoline derivatives was synthesized and evaluated against respiratory syncytial virus (RSV) in a cell-based assay and animal model. Extensive structure-activity relationship study led to a lead compound 14h , which exhibited excellent in vitro potency with an EC50 value of 0.8 nM and demonstrated 71% oral bioavailability in mice. In a mouse challenge model of RVS infection, 14h demonstrated superior efficacy with a 3.9log RSV virus load reduction in the lung following an oral dose of 50 mg/kg...
February 8, 2018: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29456757/the-natural-history-of-spinal-deformity-in-patients-with-coffin-lowry-syndrome
#20
M Welborn, S Farrell, P Knott, E Mayekar, S Mardjetko
Purpose: Little is known about the natural history of spinal deformities in Coffin-Lowry syndrome (CLS). Our goal was to evaluate the spinal deformity progression and clinical impact. Methods: In this institutional review board-approved study, we performed a multinational retrospective review of six male CLS patients, aged 13 to 22 years at final follow-up, for a mean of 7.25 years (3 to 13). Results: All showed delayed skeletal maturity. Three had calcifications of their lower cervical ligamentum flavum, all experienced neural axis abnormalities, including lower extremity weakness, numbness and tingling and in one, quadriparesis...
February 1, 2018: Journal of Children's Orthopaedics
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