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https://www.readbyqxmd.com/read/28750508/in-vitro-evidence-of-anti-inflammatory-and-anti-obesity-effects-of-medium-chain-fatty-acid-diacylglycerols
#1
Seungmin Yu, Jong Hun Choi, Hun Jung Kim, Soo Hyun Park, Gwang-Woong Go, Wooki Kim
Dietary approaches using structured lipids, including medium-chain fatty acids and diacylglycerols, have been adopted for the prevention of obesity-induced chronic inflammation. In an extension to previous studies, medium-chain fatty acid-diacylglycerol enriched dietary oil (MCDG) was prepared by interesterification of canola oil and medium-chain fatty acid-triacylglycerols. The consequent MCDG product was applied to RAW264.7 macrophages followed by the assessment of multiple inflammatory responses. Compared to conventionally used canola and olive oil controls, MCDG suppressed macrophage phagocytosis as assessed by the uptake of microsphere beads...
July 31, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28750499/exosomal-mir-9-3p-suppresses-hbgf-5-expression-and-is-a-functional-biomarker-in-hepatocellular-carcinoma
#2
Jie Tang, Yun Li, Kai Liu, Qian Zhu, Wei-Hua Yang, Liang-Kun Xiong, De-Liang Guo
BACKGROUND: Hepatocellular carcinoma (HCC) is the fifth most common cancer and the third leading cause of cancer-related death worldwide. Exosomes are secreted membrane vesicles that play important roles in various diseases by transporting proteins and RNAs, including microRNAs, between cells. However, the function of exosomal miRNA in HCC has not been fully investigated. METHODS: Exosomes were obtained from the sera by ultracentrifugation and were processed for transmission electron microscopy (TEM)...
July 27, 2017: Minerva Medica
https://www.readbyqxmd.com/read/28750478/multiple-dsm-5-substance-use-disorders-a-national-study-of-us-adults
#3
Sean Esteban McCabe, Brady T West, Emily M Jutkiewicz, Carol J Boyd
OBJECTIVE: Our aim is to determine the lifetime and past-year prevalence estimates of multiple Diagnostic and Statistical Manual of Mental Disorders fifth edition (DSM-5) substance use disorders (SUDs) among U.S. adults. METHODS: The 2012-2013 National Epidemiologic Survey on Alcohol and Related Conditions featured in-person interviews with a nationally representative sample of adults aged 18 and older. RESULTS: The majority of past-year nonalcohol DSM-5 SUDs had at least 1 other co-occurring past-year SUD, ranging from 56...
July 27, 2017: Human Psychopharmacology
https://www.readbyqxmd.com/read/28750471/modulation-of-the-activated-protein-c-pathway-in-severe-haemophilia-a-patients-the-effects-of-thrombomodulin-and-a%C3%A2-factor-v-stabilizing-fab
#4
D F Brophy, E J Martin, B M Mohammed, J C Barrett, J G Kuhn, M E Nolte, B Wiinberg, H L Holmberg, J Lund, R Salbo, E K Waters
INTRODUCTION: The thrombomodulin (TM)/activated protein C (APC) system is a key regulator of haemostasis, limiting amplification and propagation of the formed blood clot to the injury site. Dampening APC's inhibition of factor V (FV) and factor VIII (FVIII) may be a future strategy in developing next-generation therapeutic targets for haemophilia treatment. AIMS: To determine ex vivo the respective concentration-dependent effects of TM and a FV-stabilizing Fab on the APC regulatory pathway in severe FVIII-deficient blood and plasma...
July 27, 2017: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/28750402/zinc-depletion-by-tpen-induces-apoptosis-in-human-acute-promyelocytic-nb4-cells
#5
Bo Zhu, Jiayu Wang, Feng Zhou, Yingting Liu, Yueyang Lai, Jie Wang, Xiao Chen, Dianhua Chen, Lan Luo, Zi-Chun Hua
BACKGROUND/AIMS: The effects of zinc signaling on proliferation or apoptosis of leukemia cells remain elusive. In the present study, we used N, N, N', N'-tetrakis-(2-pyridylmethyl)-ethylene-diamine (TPEN), a membrane-permeable zinc chelator, to evaluate the effect of zinc depletion on survival and apoptosis of NB4 acute promyelocytic leukemia (APL) cells. METHODS: The pro-apoptotic effects of TPEN on NB4 cells were examined by flow cytometry, and observed using an optical microscope...
July 27, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28750369/matrix-metalloproteinase-polymorphisms-in-patients-with-floppy-mitral-valve-mitral-valve-prolapse-fmv-mvp-and-fmv-mvp-syndrome
#6
Sarah M Lima, Antonios A Pitsis, Timotheos G Kelpis, Mohamed H Shahin, Taimour Y Langaee, Larisa H Cavallari, Efstratios K Theofilogiannakos, Harisios Boudoulas, Konstantinos Dean Boudoulas
BACKGROUND: It has been suggested that collagen abnormalities of the mitral valve are present in patients with floppy mitral valve (FMV)/mitral valve prolapse (MVP). Genetic factors determining collagen synthesis and degradation have not been well defined in these patients. This study was undertaken to determine whether selective polymorphisms of matrix metalloproteinase-2 (MMP2) or transforming growth factor-β (TGFβ), with known or putative effects on collagen turnover, are more frequent in FMV/MVP...
July 28, 2017: Cardiology
https://www.readbyqxmd.com/read/28750368/changes-in-white-matter-integrity-following-intensive-voice-treatment-lsvt-loud%C3%A2-in-children-with-cerebral-palsy-and-motor-speech-disorders
#7
Alesha Reed, Jacqueline Cummine, Reyhaneh Bakhtiari, Cynthia M Fox, Carol A Boliek
Preliminary evidence suggests that intensive voice and speech treatment based on activity-dependent neuroplasticity principles holds promise for affecting positive change in children with cerebral palsy (CP) and motor speech disorders. Diffusion tensor imaging (DTI) allows researchers to make inferences about the integrity of white matter tracks and provides a sensitive measure of neuroplasticity. Previous treatment studies looking at the effects of training on white matter integrity have shown positive results, but these studies have been limited to gross motor function...
July 28, 2017: Developmental Neuroscience
https://www.readbyqxmd.com/read/28750366/prophylactic-treatment-with-cerium-oxide-nanoparticles-attenuate-hepatic-ischemia-reperfusion-injury-in-sprague-dawley-rats
#8
Nandini D P K Manne, Ravikumar Arvapalli, Vincent A Graffeo, Venkata V K Bandarupalli, Tolou Shokuhfar, Sweetu Patel, Kevin M Rice, Gautam Kumar Ginjupalli, Eric R Blough
BACKGROUND: Hepatic ischemia reperfusion is one the main causes for graft failure following transplantation. Although, the molecular events that lead to hepatic failure following ischemia reperfusion (IR) are diverse and complex, previous studies have shown that excessive formation of reactive oxygen species (ROS) are responsible for hepatic IR injury. Cerium oxide (CeO2) nanoparticles have been previously shown to act as an anti-oxidant and anti-inflammatory agent. Here, we evaluated the protective effects of CeO2 nanoparticles on hepatic ischemia reperfusion injury...
July 27, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28750365/a-novel-evaluation-for-predicting-aortic-complicated-lesions-using-calcification-on-chest-x-ray
#9
Yoshitaka Yamaguchi, Tomotaka Tanaka, Sohei Yoshimura, Masatoshi Koga, Kazuyuki Nagatsuka, Kazunori Toyoda
BACKGROUND: The aorta is a significant source of cerebral thromboembolisms. Aortic complicated lesions (ACLs) are key findings on transesophageal echocardiography (TEE) for assessing aortic sources of emboli to the brain. TEE is sometimes avoided due to its invasiveness. However, few reports have examined alternative methods for predicting ACLs. We investigated relationships between aortic arch calcification (AAC) on chest X-ray and ACLs. METHODS: Participants comprised 300 patients with acute ischemic stroke or transient ischemic attack who underwent TEE for the evaluation of the aortic arch and heart...
July 28, 2017: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/28750359/normal-and-anomalous-heating-rate-effects-on-thermoluminescence-of-ce-doped-znb2o4
#10
Tamer Dogan, Mehmet Yüksel, Sibel Akça, Ziyafer Gizem Portakal, Sümeyra Balci-Yegen, Nil Kucuk, Mustafa Topaksu
The effect of heating rate (HR) on thermoluminescence (TL) glow curves of 1%, 4%, and 10% Ce(3 +) doped ZnB2O4 phosphors was investigated in detail. The glow peaks are examined and, activation energy (E) and frequency factor (s) are determined by using various heating rate (VHR) method. In the obtained glow curves with nine different HRs between 2 and 10°C/s, it was observed that the TL intensities of the first peaks of all three samples and the second peak of 10% Ce(3 +) doped sample decrease with increasing HR...
July 18, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28750358/antitumor-potential-of-1-thiocarbamoyl-3-5-diaryl-4-5-dihydro-1h-pyrazoles-in-human-bladder-cancer-cells
#11
Josiane Weber Tessmann, Julieti Buss, Karine Rech Begnini, Lucas Moraes Berneira, Favero Reisdorfer Paula, Claudio Martin Pereira de Pereira, Tiago Collares, Fabiana Kömmling Seixas
Bladder cancer is a genitourinary malignant disease common worldwide. Current chemotherapy is often limited mainly due to toxicity and drug resistance. Thus, there is a continued need to discover new therapies. Recently evidences shows that pyrazoline derivatives are promising antitumor agents in many types of cancers, but there are no studies with bladder cancer. In order to find potent and novel chemotherapy drugs for bladder cancer, a series of pyrazoline derivatives 2a-2d were tested for their antitumor activity in two human bladder cancer cell lines 5647 and T24...
July 24, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28750349/escherichia-coli-maltose-binding-protein-mbp-activates-mouse-th1-through-tlr2-mediated-myd88-dependent-pathway-and-tlr4-mediated-trif-dependent-pathway
#12
GuoMu Liu, YiXin Zhang, NanNan Zhang, WeiHua Ni, Jing Jie, LiNa Jiang, GuiXiang Tai
MBP (maltose-binding protein) is a component of Escherichia coli. Our previous study found that MBP directly induces the activation of Th1 (T helper type 1), but the molecular mechanism remains unclear. In the present study, CD4(+)T cells were purified from the spleens of normal mice using antibody-coated immunomagnetic beads by negative selection. CD4(+)T cells activated with a CD3/CD28 antibody were stimulated with MBP. The results indicated that MBP elevated IFN-γ mRNA levels in activated CD4(+)T cells and promoted IFN-γ production from activated CD4(+)T cells...
July 24, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28750343/is-ambient-temperature-associated-with-risk-of-infant-mortality-a-multi-city-study-in-korea
#13
Ji-Young Son, Jong-Tae Lee, Michelle L Bell
BACKGROUND: Although numerous studies have shown increased risk of mortality from elevated temperatures for adults, limited studies have examined temperature's effect on mortality for infants. Our study investigated the city-specific and overall effects of ambient temperature on infant mortality in seven major cities in Korea, 2004-2007. METHODS: Birth cohort using a linked birth and death records included 777,570 births with 557 all-cause deaths. We estimated city-specific hazard ratios for each city using an extended Cox proportional hazards model with time-dependent covariates...
July 24, 2017: Environmental Research
https://www.readbyqxmd.com/read/28750342/the-role-of-public-and-private-natural-space-in-children-s-social-emotional-and-behavioural-development-in-scotland-a-longitudinal-study
#14
Elizabeth A Richardson, Jamie Pearce, Niamh K Shortt, Richard Mitchell
INTRODUCTION: Poor mental health in childhood has implications for health and wellbeing in later life. Natural space may benefit children's social, emotional and behavioural development. We investigated whether neighbourhood natural space and private garden access were related to children's developmental change over time. We asked whether relationships differed between boys and girls, or by household educational status. METHODS: We analysed longitudinal data for 2909 urban-dwelling children (aged 4 at 2008/9 baseline) from the Growing Up in Scotland (GUS) survey...
July 21, 2017: Environmental Research
https://www.readbyqxmd.com/read/28750341/the-enzyme-sensitive-release-of-prodigiosin-grafted-%C3%AE-cyclodextrin-and-chitosan-magnetic-nanoparticles-as-an-anticancer-drug-delivery-system-synthesis-characterization-and-cytotoxicity-studies
#15
Banafsheh Rastegari, Hamid Reza Karbalaei-Heidari, Sedigheh Zeinali, Heather Sheardown
In present investigation, two glucose based smart tumor-targeted drug delivery systems coupled with enzyme-sensitive release strategy are introduced. Magnetic nanoparticles (Fe3O4) were grafted with carboxymethyl chitosan (CS) and β-cyclodextrin (β-CD) as carriers. Prodigiosin (PG) was used as the model anti-tumor drug, targeting aggressive tumor cells. The morphology, properties and composition and grafting process were characterized by transmission electron microscope (TEM), Fourier transform infrared spectroscopy (FT-IR), vibration sample magnetometer (VSM), X-ray diffraction (XRD) analysis...
July 18, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28750339/differential-neuronal-and-glial-behavior-on-flat-and-micro-patterned-chitosan-films
#16
Marta Mattotti, Zaida Alvarez, Luis Delgado, Miguel A Mateos-Timoneda, Conrado Aparicio, Josep A Planell, Soledad Alcántara, Elisabeth Engel
Chitosan is a biodegradable natural polysaccharide that has been widely studied for regenerative purposes in the central nervous system. In this study we assessed the in vitro glial and neuronal cells response to chitosan either flat or patterned with grooves in the micrometric range. Chitosan demonstrated to be a good substrate for the attachment and growth of both neurons and glial cells. Chitosan micropatterns promoted glial cell maturation, suggesting astroglial activation. Nevertheless, those mature/reactive glial cells were permissive for axonal growth...
July 19, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28750331/the-study-of-protein-biomarkers-to-understand-the-biochemical-processes-underlying-beef-color-development-in-young-bulls
#17
Mohammed Gagaoua, E M Claudia Terlouw, Brigitte Picard
This study investigates relationships between 21 biomarkers and meat color traits of Longissimus thoracis muscles of young Aberdeen Angus and Limousin bulls. The relationships found allowed to propose metabolic processes underlying meat color. The color coordinates were related with several biomarkers. The relationships were in some cases breed-dependent and the variability explained in the regression models varied between 31 and 56%. The correlations between biomarkers and color parameters were sometimes opposite between breeds...
July 18, 2017: Meat Science
https://www.readbyqxmd.com/read/28750325/cryo-em-maps-reveal-five-fold-channel-structures-and-their-modification-by-gatekeeper-mutations-in-the-parvovirus-minute-virus-of-mice-mvm-capsid
#18
Suriyasri Subramanian, Lindsey J Organtini, Alec Grossman, Phillip P Domeier, Javier O Cifuente, Alexander M Makhov, James F Conway, Anthony D'Abramo, Susan F Cotmore, Peter Tattersall, Susan Hafenstein
In minute virus of mice (MVM) capsids, icosahedral five-fold channels serve as portals mediating genome packaging, genome release, and the phased extrusion of viral peptides. Previous studies suggest that residues L172 and V40 are essential for channel function. The structures of MVMi wildtype, and mutant L172T and V40A virus-like particles (VLPs) were solved from cryo-EM data. Two constriction points, termed the mid-gate and inner-gate, were observed in the channels of wildtype particles, involving residues L172 and V40 respectively...
July 24, 2017: Virology
https://www.readbyqxmd.com/read/28750323/differential-use-of-3-cites-by-the-subgenomic-rna-of-pea-enation-mosaic-virus-2
#19
Feng Gao, Anne E Simon
The genomic RNA (gRNA) of Pea enation mosaic virus 2 (PEMV2) is the template for p33 and -1 frameshift product p94. The PEMV2 subgenomic RNA (sgRNA) encodes two overlapping ORFs, p26 and p27, which are required for movement and stability of the gRNA. Efficient translation of p33 requires two of three 3' proximal cap-independent translation enhancers (3'CITEs): the kl-TSS, which binds ribosomes and engages in a long-distance interaction with the 5'end; and the adjacent eIF4E-binding PTE. Unlike the gRNA, all three 3'CITEs were required for efficient translation of the sgRNA, which included the ribosome-binding 3'TSS...
July 24, 2017: Virology
https://www.readbyqxmd.com/read/28750307/resilient-protein-co-expression-network-in-male-orbitofrontal-cortex-layer-2-3-during-human-aging
#20
Mohan Pabba, Enzo Scifo, Fenika Kapadia, Yuliya S Nikolova, Tianzhou Ma, Naguib Mechawar, George C Tseng, Etienne Sibille
The orbitofrontal cortex (OFC) is vulnerable to normal and pathologic aging. Currently, layer resolution large-scale proteomic studies describing "normal" age-related alterations at OFC are not available. Here, we performed a large-scale exploratory high-throughput mass spectrometry-based protein analysis on OFC layer 2/3 from 15 "young" (15-43 years) and 18 "old" (62-88 years) human male subjects. We detected 4193 proteins and identified 127 differentially expressed (DE) proteins (p-value ≤0.05; effect size >20%), including 65 up- and 62 downregulated proteins (e...
July 5, 2017: Neurobiology of Aging
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