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https://www.readbyqxmd.com/read/27914369/dna-tetrahedral-scaffolds-based-platform-for-the-construction-of-electrochemiluminescence-biosensor
#1
Qiu-Mei Feng, Zhen Zhou, Mei-Xing Li, Wei Zhao, Jing-Juan Xu, Hong-Yuan Chen
Proximal metallic nanoparticles (NPs) could quench the electrochemiluminescence (ECL) emission of semiconductor quantum dots (QDs) due to Förster energy transfer (FRET), but at a certain distance, the coupling of light-emission with surface plasmon resonance (SPR) result in enhanced ECL. Thus, the modification strategies and distances control between QDs and metallic NPs are critical for the ECL intensity of QDs. In this strategy, a SPR enhanced ECL sensor based on DNA tetrahedral scaffolds modified platform was reported for the detection of telomerase activity...
November 27, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27914359/obstructive-sleep-apnea-and-arrhythmia-a-systemic-review
#2
EDITORIAL
Nirav Patel, Caroline Donahue, Abhishek Shenoy, Arpan Patel, Nabil El-Sherif
There is a growing consensus in the scientific community that suggests a strong association between obstructive sleep apnea (OSA) and cardiovascular (CVD) conditions and events, including coronary artery disease, hypertension, arrhythmia, heart failure, and sudden cardiac death. We reviewed evidence on the relationship between OSA and arrhythmia. Our conclusion, based on our review of the literature, is that the evidence supports a strong link between OSA and cardiovascular mortality, which warrants treating OSA...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27914354/3d-qsar-predictions-for-%C3%AE-cyclodextrin-binding-constants-using-quantum-mechanically-based-descriptors
#3
Lukas Linden, Kai-Uwe Goss, Satoshi Endo
Binding of organic chemicals to α-cyclodextrin (αCD) is a typical example for host-guest complexation that is influenced by the 3D-structure of both the binding site (host) and the solute (guest). Prediction of the binding constant is challenging and requires a successful representation of the binding site-solute interactions in the 3D-space. In this study, we tested if a 3D quantitative structure activity relationship (3D-QSAR) model with quantum mechanically based local sigma profiles (LSPs) derived from the COSMOsar3D method is capable of predicting αCD binding constants from the most recent literature and how the model performs in comparison to a standard comparative molecular field analysis and to a reference 2D-QSAR...
November 30, 2016: Chemosphere
https://www.readbyqxmd.com/read/27914353/two-liquid-phase-system-a-promising-technique-for-predicting-bioavailability-of-polycyclic-aromatic-hydrocarbons-in-long-term-contaminated-soils
#4
Congying Wang, Ziyu Wang, Zengbo Li, Riaz Ahmad
A two-liquid-phase system (TLPS), which consisted of soil slurry and silicone oil, was employed to extract polycyclic aromatic hydrocarbons (PAHs) in four long-term contaminated soils in order to assess the bioavailability of PAHs. Extraction kinetics of six PAHs viz. phenanthrene, fluoranthene, pyrene, benzo(a)anthracene, benzo(a)pyrene, dibenzo(a,h)anthrancene were selected to investigate as they covered the susceptible and recalcitrant PAHs in soil. A parallel experiments were also carried out on the microbial degradation of these PAHs in soil with and without biostimulation (by adding (NH4)2HPO4)...
November 30, 2016: Chemosphere
https://www.readbyqxmd.com/read/27914352/searching-for-novel-modes-of-toxic-actions-of-oil-spill-using-e-%C3%A2-coli-live-cell-array-reporter-system-a-hebei-spirit-oil-spill-study
#5
Dawoon Jung, Miao Guan, Sangwoo Lee, Cheolmin Kim, Hyesoo Shin, Seongjin Hong, Un Hyuk Yim, Won Joon Shim, John P Giesy, Jong Seong Khim, Xiaowei Zhang, Kyungho Choi
Oil is a complex mixture of numerous compounds. Therefore, oil spills near shore can cause various adverse effects on coastal ecosystems. However, most toxicological assessments conducted on oil spill sites have focused on limited modes of toxic actions. In the present study, we utilized the Escherichia coli (E. coli) live cell array system (LCA) to identify novel modes of toxicities of the oil spill-affected sediments. For this purpose, sediment samples were collected from an area heavily polluted by Hebei Spirit oil spill (HSOS) incident of 2007...
November 30, 2016: Chemosphere
https://www.readbyqxmd.com/read/27914350/phosphorus-flows-in-a-peri-urban-region-with-intensive-food-production-a-case-study
#6
S Bittman, S C Sheppard, D Poon, D E Hunt
Excess phosphorus (P) in peri-urban regions is an emerging issue, whereas there is global depletion of quality mined supplies of P. The flow of P across the landscape leading to regional surpluses and deficits is not well understood. We computed a regional P budget with internal P flows in a fairly discreet peri-urban region (Lower Fraser Valley, BC) with closely juxtaposed agricultural and non-agricultural urban ecosystems, in order to clarify the relationship between food production, food consumption and other activities involving use of P (e...
November 30, 2016: Journal of Environmental Management
https://www.readbyqxmd.com/read/27914340/nickelocene-as-precursor-of-microporous-organometallic-derived-carbon-and-nickel-oxide-carbon-nanocomposite
#7
P González-García, D Arenas-Esteban, D Ávila-Brande, E Urones-Garrote, L C Otero-Díaz
Microporous flower-like and spherical carbon particles, made of graphene-like layers, have been obtained via chlorination of nickelocene (Ni(C5H5)2). Their mechanism of formation, in terms of morphology and micro-nanostructure, has been followed from 200 to 900°C. Conventional transmission electron microscopy and high-resolution-TEM observations allow determining that their structure is made of highly disordered graphene-like layers. The Raman spectrum of the high temperature sample exhibits the characteristics D and G bands...
November 10, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27914327/solution-processable-exfoliation-and-photoelectric-properties-of-two-dimensional-layered-mos2-photoelectrodes
#8
Qiyi Zhao, Yaohui Guo, Yixuan Zhou, Xianding Yan, Xinlong Xu
MoS2 based photoelectrodes with different thickness have been fabricated by liquid phase exfoliation and vacuum filtration method. Absorption spectra clearly demonstrated two splitting absorption peaks due to the spin-orbit coupling and first principle calculation also indicate the spin-orbit coupling effect. These results combined with the SEM and TEM measurement suggests that the randomly stacked MoS2 films can maintain the properties of few-layered materials with good quality. As a proof-of-principle applications, photoelectrochemical experiments of MoS2 based photoelectrodes manifests that these MoS2 films are one kind of reversible and stable optoelectronic materials with tunable microampere photocurrent as the change of film thickness...
November 16, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27914322/association-between-pigs-with-high-caecal-salmonella-loads-and-carcass-contamination
#9
M Pesciaroli, L Cucco, S De Luca, F R Massacci, C Maresca, L Medici, M Paniccià, E Scoccia, M Staffolani, G Pezzotti, C F Magistrali
Contaminated pork is a significant source of foodborne Salmonella infections. Pork is contaminated at the slaughterhouse; however, the mechanisms driving Salmonella contamination of carcasses are still poorly understood. The aim of this study was to investigate whether the amount of Salmonella carried by slaughtered pigs in their guts has an influence on carcass contamination. On that account, we tested whether the number of carcasses contaminated during a slaughter day was associated with the prevalence of highly contaminated pigs (HCP: Salmonella caecal loads ≥3log/g), or with the prevalence of pigs that simply carry Salmonella spp...
November 23, 2016: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/27914318/older-adults-attentional-deployment-differential-gaze-patterns-for-different-negative-mood-states
#10
Ineke Demeyer, Alvaro Sanchez, Rudi De Raedt
BACKGROUND AND OBJECTIVES: Older adults are characterized by an attentional preference for positive over negative information. Since this positivity effect is considered to be an emotion regulation strategy, it should be more pronounced when emotion regulation is needed. In contrast to previous studies that focused on the effects of sad mood on attention, we used a stressor to activate emotion regulation and evaluate the effects of different types of mood state changes. Moreover, we evaluated mood effects on attentional processes using a paradigm that allows disentangling between different attentional engagement and disengagement processes...
November 24, 2016: Journal of Behavior Therapy and Experimental Psychiatry
https://www.readbyqxmd.com/read/27914315/and-justice-for-all-examining-corruption-as-a-contextual-source-of-mental-illness
#11
Ioana van Deurzen
In the present study, I focus on the relationship between corruption and mental health as measured by the level of depressive symptoms. I use data collected by the European Social Survey in 2006, 2012 and 2014 from 99,159 individuals that lived in 24 European countries. I employ two types of analyses: static analyses, i.e., multilevel models estimated in each wave, and dynamic analyses, i.e., fixed effects models for pseudo-panel data. Both static and dynamic analyses suggested that corruption had a detrimental effect on mental health...
November 25, 2016: Social Science & Medicine
https://www.readbyqxmd.com/read/27914312/today-is-tomorrow-s-yesterday-children-s-acquisition-of-deictic-time-words
#12
Katharine A Tillman, Tyler Marghetis, David Barner, Mahesh Srinivasan
Deictic time words like "yesterday" and "tomorrow" pose a challenge to children not only because they are abstract, and label periods in time, but also because their denotations vary according to the time at which they are uttered: Monday's "tomorrow" is different than Thursday's. Although children produce these words as early as age 2 or 3, they do not use them in adult-like ways for several subsequent years. Here, we explored whether children have partial but systematic meanings for these words during the long delay before adult-like usage...
November 30, 2016: Cognitive Psychology
https://www.readbyqxmd.com/read/27914309/unique-approach-to-sensorimotor-training-with-a-new-device-combining-air-cushion-with-stochastic-translations-a-prospective-randomized-controlled-clinical-trial
#13
Christian Mittermaier, Maximilian Schindler, Benjamin Loader, Thomas Waldhoer, Clemens Ambrozy, Richard Crevenna, Karin Pieber
Sensorimotor training with a wide variety of available devices represents an important component in rehabilitation and prevention of different sports injuries and chronic diseases. The purpose of this study was to evaluate the effects of a sensorimotor training with a newly developed device, which consists of an instable platform moving on an air cushion, providing dynamic balance training by tilting and unanticipated stochastic translations on postural control. Seventy-two healthy young subjects were included in this prospective, randomized, controlled, and observer-blinded study...
November 25, 2016: Gait & Posture
https://www.readbyqxmd.com/read/27914308/regulation-of-t-helper-cell-differentiation-by-e3-ubiquitin-ligases-and-deubiquitinating-enzymes
#14
REVIEW
Si-Fa Gao, Bo Zhong, Dandan Lin
CD4 T cells are essential components of adaptive immunity and play a critical role in anti-pathogenic or anti-tumor responses as well as autoimmune and allergic diseases. Naive CD4 T cells differentiate into distinct subsets of T helper (Th) cells by various signals including TCR, costimulatory and cytokine signals. Accumulating evidence suggests that these signaling pathways are critically regulated by ubiquitination and deubiquitination, two reversible posttranslational modifications mediated by E3 ubiquitin ligases and deubiquitinating enzymes (DUBs), respectively...
November 30, 2016: International Immunopharmacology
https://www.readbyqxmd.com/read/27914304/information-seeking-by-parents-of-children-with-physical-disabilities-an-exploratory-qualitative-study
#15
M W Alsem, F Ausems, M Verhoef, M J Jongmans, J M A Meily-Visser, M Ketelaar
BACKGROUND: Evidence suggests that parents of children with disabilities feel that not all their information needs are being met, but it remains unclear how parents try to fill these information gaps. AIMS: The aim of this study is to describe how parents of children with physical disabilities search for and evaluate information. METHODS: Qualitative semi-structured interviews were conducted with 15 parents of children with a disability, aged 1...
November 30, 2016: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/27914303/a-necessary-evil-residential-placement-of-people-with-intellectual-disability-among-the-palestinian-minority-in-israel
#16
Kareem Nasser, Dalia Sachs, Amalia Sa'ar
Among the Palestinian minority in Israel, residential placement of people with intellectual disabilities [ID] is relatively new and steadily increasing, but poorly studied. A qualitative design was used to explore the process of residential placement decision by 18 parents of people with ID through semi-structured interviews. Sampling was purposive and data was analyzed thematically. Four main themes emerged representing parents' perceptions and experiences along the placement decision-making process, together indicating an experience of deeply 'conflicted parenting': (a) initial resistance to placement and its perception as abandonment and parental failure; (b) attrition following cumulative difficulties and lack of assistance; (c) resignation and reframing of placement as a necessary evil; (d) relief mixed with guilt, pain, and ambivalence following placement...
November 30, 2016: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/27914301/hierarchical-organization-in-visual-working-memory-from-global-ensemble-to-individual-object-structure
#17
Qi-Yang Nie, Hermann J Müller, Markus Conci
When remembering a natural scene, both detailed information about specific objects and summary representations such as the gist of a scene are encoded. However, formal models of change detection that are used to estimate working memory capacity, typically assume observers simply encode and maintain memory representations that are treated independently from one another without considering the (hierarchical) object or scene structure. To overcome this limitation, we present a hierarchical variant of the change detection task that attempts to formalize the role of object structure, thus, allowing for richer, more graded memory representations...
November 30, 2016: Cognition
https://www.readbyqxmd.com/read/27914294/selective-agonism-of-mglu8-receptors-by-s-3-4-dicarboxyphenylglycine-does-not-affect-sleep-stages-in-the-rat
#18
María Cavas, Gianluigi Scesa, Mercedes Martín-López, José Francisco Navarro
BACKGROUND: Metabotropic glutamate receptors (mGlu) play a role in a number of physiological processes and behaviors, as well as in certain pathological conditions and diseases. New drugs targetting mGlu receptors are being developed with treatment purposes. Recent data indicates that glutamate is involved in sleep, and pharmacological manipulation of distinct subtypes of mGlu receptors affect sleep. Here the consequences of selective pharmacological agonism of mGlu8 receptor upon sleep and wakefulness are explored for the first time...
September 22, 2016: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/27914293/diethylcarbamazine-attenuates-lps-induced-acute-lung-injury-in-mice-by-apoptosis-of-inflammatory-cells
#19
Ingrid Tavares Fragoso, Edlene Lima Ribeiro, Fabiana Oliveira Dos Santos Gomes, Mariana Aragão Matos Donato, Amanda Karolina Soares Silva, Amanda Costa O de Oliveira, Shyrlene Meiry da Rocha Araújo, Karla Patrícia Sousa Barbosa, Laise Aline Martins Santos, Christina Alves Peixoto
BACKGROUND: Acute lung injury (ALI) is characterized by extensive neutrophil infiltration, and apoptosis delay considered part of the pathogenesis of the condition. Despite great advances in treatment strategies, few effective therapies are known for ALI. Diethylcarbamazine (DEC) is used against lymphatic filariasis, a number of studies have described its anti-inflammatory activities and pro-apoptotic effect. These properties have been associated with nuclear factor kappa-B inactivation...
September 24, 2016: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/27914288/the-use-of-red-mud-as-an-immobiliser-for-metal-metalloid-contaminated-soil-a-review
#20
REVIEW
Yumei Hua, Kate V Heal, Wolfgang Friesl-Hanl
This review focuses on the applicability of red mud as an amendment for metal/metalloid-contaminated soil. The varying properties of red muds from different sources are presented as they influence the potentially toxic element (PTE) concentration in amended soil. Experiments conducted worldwide from the laboratory to the field scale are screened and the influencing parameters and processes in soils are highlighted. Overall red mud amendment is likely to contribute to lowering the PTE availability in contaminated soil...
November 28, 2016: Journal of Hazardous Materials
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