Ashley M Fuller, Hawley C Pruitt, Ying Liu, Valerie M Irizarry-Negron, Hehai Pan, Hoogeun Song, Ann DeVine, Rohan S Katti, Samir Devalaraja, Gabrielle E Ciotti, Michael V Gonzalez, Erik F Williams, Ileana Murazzi, Dimitris Ntekoumes, Nicolas Skuli, Hakon Hakonarson, Daniel J Zabransky, Jose G Trevino, Ashani Weeraratna, Kristy Weber, Malay Haldar, Joseph A Fraietta, Sharon Gerecht, T S Karin Eisinger-Mathason
CD8+ T cell dysfunction impedes anti-tumor immunity in solid cancers but the underlying mechanisms are diverse and poorly understood. Extracellular matrix (ECM) composition has been linked to impaired T cell migration and enhanced tumor progression; however, impacts of individual ECM molecules on T cell function in the tumor microenvironment (TME) are only beginning to be elucidated. Upstream regulators of aberrant ECM deposition and organization in solid tumors are equally ill-defined. Therefore, we investigated how ECM composition modulates CD8+ T cell function in undifferentiated pleomorphic sarcoma (UPS), an immunologically active desmoplastic tumor...
April 23, 2024: Journal of Clinical Investigation