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https://www.readbyqxmd.com/read/29353457/fasting-and-fast-food-diet-play-an-opposite-role-in-mice-brain-aging
#1
Paola Castrogiovanni, Giovanni Li Volti, Cristina Sanfilippo, Daniele Tibullo, Fabio Galvano, Michele Vecchio, Roberto Avola, Ignazio Barbagallo, Lucia Malaguarnera, Sergio Castorina, Giuseppe Musumeci, Rosa Imbesi, Michelino Di Rosa
Fasting may be exploited as a possible strategy for prevention and treatment of several diseases such as diabetes, obesity, and aging. On the other hand, high-fat diet (HFD) represents a risk factor for several diseases and increased mortality. The aim of the present study was to evaluate the impact of fasting on mouse brain aging transcriptome and how HFD regulates such pathways. We used the NCBI Gene Expression Omnibus (GEO) database, in order to identify suitable microarray datasets comparing mouse brain transcriptome under fasting or HFD vs aged mouse brain transcriptome...
January 20, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29353441/pre-and-postoperative-management-of-risk-factors-for-postoperative-delirium-who-is-in-charge-and-what-is-its-essence
#2
Bruno Neuner, Daniel Hadzidiakos, Gabriella Bettelli
Postoperative delirium (POD) is an adverse clinical outcome characterized by cognitive, affective and behavioral symptoms with typically an acute onset and a fluctuating course. POD is attributed to certain patients' predisposing factors as well as to treatment-related precipitating factors. While there are several single-component interventions for the prevention of POD, evolving evidence suggests the importance of a system approach in the prevention of POD. This involves strategies by multidisciplinary teams with additional geriatric consultation services to identify risk factors for POD and to modify their impact on the perioperative course...
January 20, 2018: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29353433/recent-trends-and-analytical-challenges-in-plant-bioactive-peptide-separation-identification-and-validation
#3
REVIEW
Susy Piovesana, Anna Laura Capriotti, Chiara Cavaliere, Giorgia La Barbera, Carmela Maria Montone, Riccardo Zenezini Chiozzi, Aldo Laganà
Interest in research into bioactive peptides (BPs) is growing because of their health-promoting ability. Several bioactivities have been ascribed to peptides, including antioxidant, antihypertensive and antimicrobial properties. As they can be produced from precursor proteins, the investigation of BPs in foods is becoming increasingly popular. For the same reason, production of BPs from by-products has also emerged as a possible means of reducing waste and recovering value-added compounds suitable for functional food production and supplements...
January 20, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29353391/detection-of-sleep-disordered-breathing-with-ambulatory-holter-monitoring
#4
Ian Grasso, Mark Haigney, David Mortara, Jacob F Collen, Jordanna Hostler, Aimee Moores, Karen Sheikh, William Kelly
PURPOSE: Obstructive sleep apnea (OSA) syndrome is a common condition that can impact clinical outcomes among patients with cardiovascular disease. Screening all subjects with heart disease via polysomnography (PSG) is costly and resource-limited. We sought to compare a Holter monitor-based algorithm to detect OSA to in-laboratory polysomnography (PSG). METHODS: Prospective cohort study of patients undergoing in-laboratory attended PSG for the evaluation of OSA...
January 20, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29353387/inter-individual-variation-in-health-and-disease-associated-with-pulmonary-infectious-agents
#5
Kirsten C Verhein, Heather L Vellers, Steven R Kleeberger
Respiratory infectious diseases resulting from bacterial or viral pathogens such as Mycobacterium tuberculosis, Streptococcus pneumoniae, respiratory syncytial virus (RSV), or influenza, are major global public health concerns. Lower respiratory tract infections are leading causes of morbidity and mortality, only behind ischemic heart disease and stroke (GBD 2015 LRI Collaborators in Lancet Infect Dis 17(11):1133-1161, 2017). Developing countries are particularly impacted by these diseases. However, while many are infected with viruses such as RSV (> 90% of all individuals are infected by age 2), only sub-populations develop severe disease...
January 20, 2018: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/29353385/the-relative-importance-of-clinical-economic-patient-values-and-feasibility-criteria-in-cancer-drug-reimbursement-in-canada-a-revealed-preferences-analysis-of-recommendations-of-the-pan-canadian-oncology-drug-review-2011-2017
#6
Chris Skedgel, Dominika Wranik, Min Hu
BACKGROUND: Most Canadian provinces and territories rely on the pan-Canadian Oncology Drug Review (pCODR) to provide recommendations regarding public reimbursement of cancer drugs. The pCODR review process considers four dimensions of value-clinical benefit, economic evaluation, patient-based values and adoption feasibility-but they do not define weights for individual decision criteria or an acceptable threshold for any of the criteria. Given this implicit review process, it is of interest to understand which factors appear to carry the most weight in pCODR recommendations using a revealed preferences approach...
January 20, 2018: PharmacoEconomics
https://www.readbyqxmd.com/read/29353361/liming-induces-carbon-dioxide-co2-emission-in-psb-inoculated-alkaline-soil-supplemented-with-different-phosphorus-sources
#7
Muhammad Adnan, Zahir Shah, Muhammad Sharif, Hidayatur Rahman
Agricultural land is a major sink of global organic carbon (C). Its suitable management is crucial for improving C sequestration and reducing soil CO2 emission. Incubation experiments were performed to assess the impact of phosphate solubilizing bacterial (PSB) inoculation (inoculated and uninoculated) and soil calcification (4.78, 10, 15, and 20% crushed CaCO3) with phosphorus (P) sources [single superphosphate (SSP), rock phosphate (RP), farm yard manure (FYM), and poultry manure (PM)] in experiment 1 and with various rates of PM (4, 8, and 12 kg ha-1) in experiment 2 on cumulative soil respiration...
January 20, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29353360/in-situ-monitoring-of-the-sinos-river-southern-brazil-water-quality-parameters-biomarkers-and-metal-bioaccumulation-in-fish
#8
Thaís Dalzochio, Gabriela Zimmermann Prado Rodrigues, Leonardo Airton Ressel Simões, Mateus Santos de Souza, Ismael Evandro Petry, Natália Bordin Andriguetti, Gláucia Joselaine Herbert Silva, Luciano Basso da Silva, Günther Gehlen
The Sinos River is an important water supply in Southern Brazil and receives industrial, agricultural, and domestic effluents which may affect aquatic biota. Water physicochemical and microbiological analyses, biomarker responses (scaled mass index (SMI), gill histopathology, and micronucleus and nuclear abnormality (MN and NA) frequencies), and metal bioaccumulation in muscle were assessed in the fish species Bryconamericus iheringii (Characidae) captured at three sampling sites (S1, S2, and S3) in four sampling periods...
January 20, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29353358/modeling-the-impact-of-transport-energy-consumption-on-co2-emission-in-pakistan-evidence-from-ardl-approach
#9
Danish, Muhammad Awais Baloch, Shah Suad
The objective of this research is to examine the relationship between transport energy consumption, economic growth, and carbon dioxide emission (CO2) from transport sector incorporating foreign direct investment and urbanization. This study is carried out in Pakistan by applying autoregressive distributive lag (ARDL) and vector error correction model (VECM) over 1990-2015. The empirical results indicate a strong significant impact of transport energy consumption on CO2 emissions from the transportation sector...
January 20, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29353349/daclatasvir-a-review-of-preclinical-and-clinical-pharmacokinetics
#10
REVIEW
Yash Gandhi, Timothy Eley, Aberra Fura, Wenying Li, Richard J Bertz, Tushar Garimella
Daclatasvir is a first-in-class, highly selective, hepatitis C virus, non-structural protein 5a polymerase replication complex inhibitor with picomolar potency and broad genotypic coverage in vitro. Daclatasvir undergoes rapid absorption, with a time to reach maximum plasma concentration of 1-2 h and an elimination half-life of ~ 10 to 14 h observed in single-ascending dose studies. Steady state was achieved by day 4 in multiple-ascending dose studies. Daclatasvir can be administered without regard to food or pH modifiers...
January 20, 2018: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/29353339/chronic-pain-discomfort-quality-of-life-and-impact-on-sex-life-after-open-inguinal-hernia-mesh-repair-an-expertise-based-randomized-clinical-trial-comparing-lightweight-and-heavyweight-mesh
#11
M Rutegård, R Gümüsçü, G Stylianidis, P Nordin, E Nilsson, M M Haapamäki
PURPOSE: There is a paucity of high-quality evidence concerning mesh choice in open inguinal hernia repair. Using an expertise-based randomized clinical trial design, we aimed to evaluate the postoperative impact of two different mesh types on pain and discomfort, quality of life and sex life. METHODS: In two regional hospitals, male patients with primary inguinal hernia were randomized to one of two groups of surgeons that performed the Lichtenstein operation. One group of surgeons used a heavyweight polypropylene mesh (90 g/m2, Bard™ Flatmesh, Davol) while the second group employed a lightweight mesh (28 g/m2, ULTRAPRO™, Ethicon)...
January 20, 2018: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/29353326/radiological-and-functional-outcomes-of-high-grade-spondylolisthesis-treated-by-intrasacral-fixation-dome-resection-and-circumferential-fusion-a-retrospective-series-of-20-consecutive-cases-with-a-minimum-of-2%C3%A2-years-follow-up
#12
E Ferrero, B Ilharreborde, V Mas, C Vidal, A-L Simon, K Mazda
PURPOSE: Major concern during surgery for high-grade spondylolisthesis (HGS) is to reduce lumbosacral kyphosis and restore sagittal alignment. Despite the numerous methods described, lumbosacral fixation in HGS is a challenging technique associated with high complication rate. Few series have described outcomes and most of the results are limited to lumbosacral correction without global sagittal alignment analysis. This study aims at analyzing clinical and radiological outcomes of HGS patients treated with intrasacral rods on full spine radiographs...
January 20, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29353325/a-head-to-tail-view-of-l-selectin-and-its-impact-on-neutrophil-behaviour
#13
REVIEW
Aleksandar Ivetic
L-selectin is a type I transmembrane cell adhesion molecule expressed on most circulating leukocytes, including neutrophils. Engagement of L-selectin with endothelial-derived ligands initiates neutrophil tethering and rolling behaviour along luminal walls of post-capillary venules, constituting the first step of the multi-step adhesion cascade. There is a large body of evidence to suggest that signalling downstream of L-selectin can influence neutrophil behaviour: adhesion, migration and priming. This review will cover aspects of L-selectin form and function and introduce the "triad of L-selectin regulation", highlighting the inextricable links between adhesion, signalling and ectodomain shedding and also highlighting the cytosolic proteins that interconnect them...
January 20, 2018: Cell and Tissue Research
https://www.readbyqxmd.com/read/29353311/effects-of-wrist-tendon-vibration-and-eye-movements-on-manual-aiming
#14
Ann Lavrysen, Oron Levin, Matthieu P Boisgontier, Digby Elliott, Werner F Helsen
In the present study, we investigated whether visual information mediates a proprioceptive illusion effect induced by muscle tendon vibration in manual aiming. Visual information was gradually degraded from a situation in which the targets were present and participants (n = 20; 22.3 ± 2.7 years) were permitted to make saccadic eye movements to designated target positions, to a condition in which the targets were not visible and participants were required to perform cyclical aiming while fixating a point between the two target positions...
January 20, 2018: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/29353305/an-investigation-of-the-critical-events-and-influential-factors-to-the-evolution-of-the-u-s-man-and-the-biosphere-program
#15
Jennifer M Thomsen
The UNESCO Man and the Biosphere program has operated for 45 years as an international program that started in the 1970s to conserve biotic communities and provide areas for research, education, and training. The program later evolved in the 1990s to address social and environmental issues in a sustainable manner across a landscape. This program was one of the first efforts that recognized the importance of working beyond park and protected area boundaries and the need to sustain livelihoods as much as the resources...
January 20, 2018: Environmental Management
https://www.readbyqxmd.com/read/29353291/editorial-impact-of-the-binge-drinking-bd-in-adolescence-are-we-doing-it-right-editorial-impacto-del-consumo-epis%C3%A3-dico-excesivo-de-alcohol-en-la-adolescencia-%C3%A2-lo-estamos-haciendo-bien
#16
Ana Magdalena Vargas-Martínez, Marta Trapero-Bertran, Eugenia Gil-García, Marta Lima-Serrano
Nowadays, one of the most prevalent patterns of alcohol consumption is called binge drinking (BD). In 2015, the European School Survey Project on Alcohol and Drugs (ESPAD) Group estimated that about 35% of adolescents of 15-16 years old have had at least one BD occasion in the past 30 days while at national level, the series of surveys on the use of drugs in adolescents of secondary education (ESTUDES, 2014-2015) determined that 32.2% of adolescents stated having performed BD in the last month. The aim of this editorial was to update the context of adolescence drinking and analysing the impact of BD by ages, including health and social costs derived...
January 15, 2018: Adicciones
https://www.readbyqxmd.com/read/29353274/postoperative-immobilization-following-occipitocervical-fusion-in-the-pediatric-population-outcome-evaluation-and-review-of-literature
#17
Alexandre R Pingarilho, Paulo M Porto de Melo, Samer K Elbabaa
The scientific literature does not have a consensus about the role and method of postoperative immobilization after occipitocervical fusion in the pediatric population. The primary goal of this study is to review the medical literature and evaluate different immobilization methods and their impact on fusion, following the surgical management of craniocervical instability in children. It started with an extensive research of randomized controlled trials, series of cases and case reports, describing occipitocervical junction pathologies, clinical, epidemiological characteristics, and treatment...
January 20, 2018: Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29353273/metabolomics-in-sepsis-and-its-impact-on-public-health
#18
Nikolaos Evangelatos, Pia Bauer, Matthias Reumann, Kapaettu Satyamoorthy, Hans Lehrach, Angela Brand
Sepsis, with its often devastating consequences for patients and their families, remains a major public health concern that poses an increasing financial burden. Early resuscitation together with the elucidation of the biological pathways and pathophysiological mechanisms with the use of "-omics" technologies have started changing the clinical and research landscape in sepsis. Metabolomics (i.e., the study of the metabolome), an "-omics" technology further down in the "-omics" cascade between the genome and the phenome, could be particularly fruitful in sepsis research with the potential to alter the clinical practice...
January 19, 2018: Public Health Genomics
https://www.readbyqxmd.com/read/29353261/impact-of-delivered-tidal-volume-on-the-occurrence-of-intraventricular-haemorrhage-in-preterm-infants-during-positive-pressure-ventilation-in-the-delivery-room
#19
Qaasim Mian, Po-Yin Cheung, Megan O'Reilly, Samantha K Barton, Graeme R Polglase, Georg M Schmölzer
BACKGROUND AND OBJECTIVES: Delivery of inadvertent high tidal volume (VT) during positive pressure ventilation (PPV) in the delivery room is common. High VT delivery during PPV has been associated with haemodynamic brain injury in animal models. We examined if VT delivery during PPV at birth is associated with brain injury in preterm infants <29 weeks' gestation. METHODS: A flow-sensor was placed between the mask and the ventilation device. VT values were compared with recently described reference ranges for VT in spontaneously breathing preterm infants at birth...
January 20, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/29353243/impact-of-order-set-design-on-urine-culturing-practices-at-an-academic-medical-centre-emergency-department
#20
Satish Munigala, Ronald R Jackups, Robert F Poirier, Stephen Y Liang, Helen Wood, S Reza Jafarzadeh, David K Warren
BACKGROUND: Urinalysis and urine culture are commonly ordered tests in the emergency department (ED). We evaluated the impact of removal of order sets from the 'frequently ordered test' in the computerised physician order entry system (CPOE) on urine testing practices. METHODS: We conducted a before (1 September to 20 October 2015) and after (21 October to 30 November 2015) study of ED patients. The intervention consisted of retaining 'urinalysis with reflex to microscopy' as the only urine test in a highly accessible list of frequently ordered tests in the CPOE system...
January 20, 2018: BMJ Quality & Safety
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