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https://www.readbyqxmd.com/read/28528518/a-multi-gene-panel-study-in-hereditary-breast-and-ovarian-cancer-in-colombia
#1
A M Cock-Rada, C A Ossa, H I Garcia, L R Gomez
Germline mutations in BRCA1 and BRCA2 account for approximately 50% of inherited breast and ovarian cancers. Three founder mutations in BRCA1/2 have been reported in Colombia, but the pattern of mutations in other cancer susceptibility genes is unknown. This study describes the frequency and type of germline mutations in hereditary breast and/or ovarian cancer genes in a referral cancer center in Colombia. Eighty-five women referred to the oncogenetics unit of the Instituto de Cancerologia Las Americas in Medellin (Colombia), meeting testing criteria for hereditary breast and ovarian cancer syndrome (NCCN 2015), who had germline testing with a commercial 25-gene hereditary cancer panel, were included in the analysis...
May 20, 2017: Familial Cancer
https://www.readbyqxmd.com/read/28528504/assessment-of-trace-metal-accumulation-in-native-mussels-brachidontes-rodriguezii-from-a-south-american-temperate-estuary
#2
Natalia Sol Buzzi, Ana Laura Oliva, Andrés Hugo Arias, Jorge Eduardo Marcovecchio
The present work provides the first results in heavy metal bioaccumulation in the autochthonous mussel Brachidontes rodriguezii from the Bahía Blanca Estuary (Argentina), one of the most important coastal environments of South America, subjected to different anthropogenic pressure. The study is based on the detection of Cd, Cu, Pb, Mn, and Fe in mussels' soft tissue and sediments' fine fraction by means of inductively coupled plasma atomic emission spectroscopy (ICP-OES), in order to analyze the potential relationship between both components of the aquatic system...
May 20, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28528483/fossil-record-of-ephedra-in-the-lower-cretaceous-aptian-argentina
#3
Gabriela G Puebla, Ari Iglesias, María A Gómez, Mercedes B Prámparo
Fossil plants from the Lower Cretaceous (upper Aptian) of the La Cantera Formation, Argentina, are described. The fossils studied represent a leafy shooting system with several orders of articulated and striated axes and attached leaves with unequivocal ephedroid affinity. We also found associated remains of ovulate cones with four whorls of sterile bracts, which contain two female reproductive units (FRU). Ovulate cone characters fit well within the genus Ephedra. Special characters in the ovulate cones including an outer seed envelope with two types of trichomes, allowed us to consider our remains as a new Ephedra species...
May 20, 2017: Journal of Plant Research
https://www.readbyqxmd.com/read/28528090/key-odor-and-physicochemical-characteristics-of-raw-and-roasted-jicaro-seeds-crescentia-alata-k-h-b
#4
Carla Vaneza Corrales, Marc Lebrun, Fabrice Vaillant, Marie Noelle Madec, Sylvie Lortal, Ana Mercedes Pérez, Geneviève Fliedel
Jicaro seeds (Crescentia alata) are widely consumed in Central America, primarily as a popular tasty and nutritious beverage called "horchata". Seeds are roasted to develop a specific aroma through a process that has never been explored. Volatile compounds, extracted from raw and roasted jicaro seeds (140°C for 140s) by SAFE (Solvent Assisted Flavor Evaporation), were analyzed by Gas Chromatography/Mass Spectrometry (GC/MS). Twenty-seven volatile compounds were isolated, among which, ethyl-2-methylbutyrate was designated by olfactometry as providing the characteristic jicaro note (0...
June 2017: Food Research International
https://www.readbyqxmd.com/read/28527649/antimicrobial-activity-of-fidaxomicin-against-clostridium-difficile-clinical-isolates-in-aichi-area-in-japan
#5
Yuka Yamagishi, Naoya Nishiyama, Yusuke Koizumi, Yoko Matsukawa, Hiroyuki Suematsu, Mao Hagihara, Kiyomitsu Katsumata, Hiroshige Mikamo
We evaluated the susceptibility of 100 Japanese Clostridium difficile isolates to fidaxomicin, a new macrocyclic antibiotic. The minimum inhibitory concentration (MIC) range of fidaxomicin was 0.03-0.5 μg/mL, with a MIC for inhibition of 50% (MIC50) of 0.12 μg/mL, and for inhibition of 90% (MIC90) of 0.25 μg/mL. We also evaluated the susceptibilities of the same 100 C. difficile isolates to vancomycin, metronidazole, moxifloxacin, clindamycin, meropenem, and ampicillin. Of all the antibiotics tested, fidaxomicin showed the most potent antimicrobial activity against this group of C...
May 17, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28527524/c9orf72-hexanucleotide-repeat-expansions-and-ataxin-2-intermediate-length-repeat-expansions-in-indian-patients-with-amyotrophic-lateral-sclerosis
#6
Priyam Narain, James Gomes, Rohit Bhatia, Inder Singh, Perumal Vivekanandan
Repeat expansions in the chromosome 9 open reading frame 72 (C9orf72) gene have been recognized as a major contributor to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia in the Caucasian population. Intermediate length repeat expansions of CAG (polyQ) repeat in the ATXN2 gene have also been reported to increase the risk of developing ALS in North America and Europe. We screened 131 ALS patients and 127 healthy controls from India for C9orf72 and ATXN2 repeat expansions. We found pathogenic hexanucleotide expansions in 3 of the 127 sporadic ALS patients, in 1 of the 4 familial ALS patients, and in none of the healthy controls...
April 26, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28527382/global-burden-of-road-traffic-accidents-in-older-adults-a-systematic-review-and-meta-regression-analysis
#7
Boon Hong Ang, Won Sun Chen, Shaun Wen Huey Lee
PURPOSE OF THE STUDY: This study aims to estimate the burden of road traffic accidents and death among older adults. DESIGN AND METHODS: A systematic literature review was conducted on 10 electronic databases for articles describing Road Traffic Accident(RTA) mortality in older adults until September 2016. A random-effects meta-regression analyses was conducted to estimate the pooled rates of road traffic accidents and death. RESULTS: A total 5018 studies were identified and 23 studies were included...
May 13, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28527292/-triatoma-dimidiata-in-colombia-distribution-ecology-and-epidemiological-importance
#8
Óscar Quirós-Gómez, Nicolás Jaramillo, Víctor Angulo, Gabriel Parra-Henao
Triatoma dimidiata is an important vector of Chagas disease in Central America and countries of northern South America. In Colombia, it has a wide geographical distribution with reported presence in 14 departments in the Andean, Caribbean, Eastern plains and Upper Magdalena regions, where it occupies different natural and artificial ecotopes. The species is considered a secondary vector in the transmission of Trypanosoma cruzi. Its presence in wild, peridomestic and intradomiciliary habitats in the Andean region, coupled with its ability to move between them, has allowed it to escape the control based on pyrethroids spraying, highlighting its importance in maintaining transmission of the parasite through the potential reinfestation of homes...
June 1, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/28527287/-identification-of-the-mycobacterium-tuberculosis-beijing-lineage-in-ecuador
#9
Patricia Jiménez, Karina Calvopiña, Diana Herrera, Carlos Rojas, Laura Pérez-Lago, Marcelo Grijalva, Remedios Guna, Darío García-de Viedma
INTRODUCTION: Mycobacterium tuberculosis Beijing lineage isolates are considered to be especially virulent, transmissible and prone to acquire resistances. Beijing strains have been reported worldwide, but studies in Latin America are still scarce. The only multinational study performed in the region indicated a heterogeneous distribution for this lineage, which was absent in Chile, Colombia and Ecuador, although further studies found the lineage in Chile and Colombia. OBJECTIVE: To search for the presence of the Beijing lineage in Ecuador, the only country in the region where it remains unreported...
June 1, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/28527249/-sociodemographic-and-clinical-characteristics-of-patients-infected-with-leptospira-spp-treated-at-four-hospitals-in-medell%C3%A3-n-colombia-2008-2013
#10
Lina María Echeverri-Toro, Sara Penagos, Laura Castañeda, Pablo Villa, Santiago Atehortúa, Faiver Ramírez, Carlos Restrepo, Sigifredo Ospina, Yuli Agudelo, Alicia Hidrón, Paola Agudelo, Eliana Valderrama, Carlos Andrés Agudelo
INTRODUCTION: Leptospirosis remains a significant health problem in tropical regions including Latin America, where its presentation is 100 times higher than that observed in other regions of the world. Mortality reaches 10% in severe cases. Its diagnosis is challenging because clinical manifestations during the initial phase are non-specific and because of limited availability of diagnostic tests. OBJECTIVE: To describe the demographic and clinical characteristics and the outcomes in hospitalized patients with leptospirosis...
January 24, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/28527211/alzheimer-s-disease-in-the-latino-community-intersection-of-genetics-and-social-determinants-of-health
#11
Irving E Vega, Laura Y Cabrera, Cassandra M Wygant, Daniel Velez-Ortiz, Scott E Counts
Alzheimer's disease (AD) is the most common type of dementia among individuals 65 or older. There are more than 5 million diagnosed cases in the US alone and this number is expected to triple by 2050. Therefore, AD has reached epidemic proportions with significant socioeconomic implications. While aging in general is the greatest risk factor for AD, several additional demographic factors that have contributed to the rise in AD in the US are under study. One such factor is associated with the relatively fast growth of the Latino population...
May 17, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28527182/water-for-agriculture-the-convergence-of-sustainability-and-safety
#12
Sarah M Markland, David Ingram, Kalmia E Kniel, Manan Sharma
Agricultural water is a precious and limited resource. Increasingly more water types and sources are being explored for use in irrigation within the United States and across the globe. As outlined in this chapter, the Produce Safety Rule (PSR) in the Food Safety and Modernization Act (FSMA) provide irrigation water standards for application of water to fruits and vegetables consumed raw. These rules for production and use of water will continue to develop and be required as the world experiences aspects of a changing climate including flooding as well as drought conditions...
May 2017: Microbiology Spectrum
https://www.readbyqxmd.com/read/28526564/direct-detection-of-anaplasma-phagocytophilum-by-polymerase-chain-reaction-followed-by-electrospray-ionization-mass-spectrometry-from-human-blood
#13
Heimo Lagler, Nicole Harrison, Manuel Kussmann, Markus Obermüller, Heinz Burgmann, Athanasios Makristathis, Michael Ramharter
Bacterial pathogens not detectable in commercial blood culture assays constitute an important challenge for infectious disease physicians, in particular if clinical symptoms of the illness are unspecific. In this report Anaplasma phagocytophilum was detected directly from a peripheral blood sample of a febrile patient reporting a tick bite by a commercial system based on polymerase chain reaction followed by electrospray ionization mass spectrometry. Therefore, the diagnosis of human granulocytic anaplasmosis infection was established by this diagnostic methodology for the first time...
May 16, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28526213/epidemiology-of-neurocysticercosis-and-epilepsy-is-everything-described
#14
REVIEW
Jose F Tellez-Zenteno, Lizbeth Hernandez-Ronquillo
In recent years clinical and epidemiological research on cysticercosis has gained significant interest in some countries, especially in Latin American countries and some countries in Asia and Africa. For many years it has been proposed that the higher prevalence of epilepsy seen in some regions such as Latin-America could be explained by parasitic infections, particularly neurocysticercosis (NCC). In this review we discussed selected epidemiological topics of the association of NCC and epilepsy, such as global distribution around the world, identification of NCC in developed countries, drug resistant epilepsy and NCC...
May 16, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28525510/zika-virus-obstetric-and-pediatric-anesthesia-considerations
#15
Jacqueline L Tutiven, Benjamin T Pruden, James S Banks, Mario Stevenson, David J Birnbach
As of November 2016, the Florida Department of Health (FDH) and the Centers for Disease Control and Prevention have confirmed more than 4000 travel-related Zika virus (ZIKV) infections in the United States with >700 of those in Florida. There have been 139 cases of locally acquired infection, all occurring in Miami, Florida. Within the US territories (eg, Puerto Rico, US Virgin Islands), >30,000 cases of ZIKV infection have been reported. The projected number of individuals at risk for ZIKV infection in the Caribbean and Latin America approximates 5 million...
June 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28524874/impact-of-simultaneous-exposure-to-arboviruses-on-infection-and-transmission-by-aedes-aegypti-mosquitoes
#16
Claudia Rückert, James Weger-Lucarelli, Selene M Garcia-Luna, Michael C Young, Alex D Byas, Reyes A Murrieta, Joseph R Fauver, Gregory D Ebel
The recent emergence of both chikungunya and Zika viruses in the Americas has significantly expanded their distribution and has thus increased the possibility that individuals may become infected by more than one Aedes aegypti-borne virus at a time. Recent clinical data support an increase in the frequency of coinfection in human patients, raising the likelihood that mosquitoes could be exposed to multiple arboviruses during one feeding episode. The impact of coinfection on the ability of relevant vector species to transmit any of these viruses (that is, their vector competence) has not been determined...
May 19, 2017: Nature Communications
https://www.readbyqxmd.com/read/28524788/state-of-global-pediatric-neurosurgery-outreach-survey-by-the-international-education-subcommittee
#17
Matthew C Davis, Brandon G Rocque, Ash Singhal, Thomas Ridder, Jogi V Pattisapu, James M Johnston
OBJECTIVE Neurosurgical services are increasingly recognized as essential components of surgical care worldwide. The degree of interest among neurosurgeons regarding international work, and the barriers to involvement in global neurosurgical outreach, are largely unexplored. The authors distributed a survey to members of the American Association of Neurological Surgeons/Congress of Neurological Surgeons (AANS/CNS) Joint Section on Pediatric Neurosurgery to assess the state of global outreach among its members and to identify barriers to involvement...
May 19, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/28524117/ebutterfly-leveraging-massive-online-citizen-science-for-butterfly-consevation
#18
Kathleen L Prudic, Kent P McFarland, Jeffrey C Oliver, Rebecca A Hutchinson, Elizabeth C Long, Jeremy T Kerr, Maxim Larrivée
Data collection, storage, analysis, visualization, and dissemination are changing rapidly due to advances in new technologies driven by computer science and universal access to the internet. These technologies and web connections place human observers front and center in citizen science-driven research and are critical in generating new discoveries and innovation in such fields as astronomy, biodiversity, and meteorology. Research projects utilizing a citizen science approach address scientific problems at regional, continental, and even global scales otherwise impossible for a single lab or even a small collection of academic researchers...
May 18, 2017: Insects
https://www.readbyqxmd.com/read/28524093/protective-effect-of-dietary-calcium-intake-on-esophageal-cancer-risk-a-meta-analysis-of-observational-studies
#19
Qianwen Li, Lingling Cui, Yalan Tian, Han Cui, Li Li, Weifeng Dou, Haixia Li, Ling Wang
Although several epidemiological studies have investigated the association between dietary calcium intake and the risk of esophageal cancer, the results are inconsistent. This study aimed to make a comprehensive evaluation regarding the association between calcium intake and risk of esophageal cancer through a meta-analysis approach. We searched for all relevant articles from the inception to April 2017, using PUBMED, EMBASE, and Web of Knowledge. The pooled odds ratio (ORs) with the 95% confidence interval (95% CI) for the highest versus the lowest categories of calcium intake was calculated using a Mantel-Haenszel fixed-effect model...
May 18, 2017: Nutrients
https://www.readbyqxmd.com/read/28523489/occurrence-of-ornithonyssus-sylviarum-in-pet-birds-from-the-district-of-set%C3%A3%C2%BAbal-portugal
#20
Helga Waap, Diana Paulino, Rita Cardoso
Ornithonyssus sylviarum is a blood-feeding ectoparasite of birds and the most serious pest in poultry farms in North America. Although the mites are typically adapted to temperate climates, information on this mite in Europe is sparse, and Dermanyssus gallinae is considered to be the only mite impacting the poultry industry. The present study reports the occurrence of O. sylviarum in pet birds in Portugal. Mites were collected directly from birds and with traps placed in cages and nests at 20 different sampling places belonging to 6 municipalities in the district of Setúbal...
May 18, 2017: Parasitology Research
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