keyword
MENU ▼
Read by QxMD icon Read
search

LBD

keyword
https://www.readbyqxmd.com/read/28211817/post-stroke-acquired-amusia-a-comparison-between-right-and-left-brain-hemispheric-damages
#1
Zahra Jafari, Mahdiye Esmaili, Ahmad Delbari, Masoud Mehrpour, Majid H Mohajerani
BACKGROUND: Although extensive research has been published about the emotional consequences of stroke, most studies have focused on emotional words, speech prosody, voices, or facial expressions. The emotional processing of musical excerpts following stroke has been relatively unexplored. OBJECTIVE: The present study was conducted to investigate the effects of chronic stroke on the recognition of basic emotions in music. METHODS: Seventy persons, including 25 normal controls (NC), 25 persons with right brain damage (RBD) from stroke, and 20 persons with left brain damage (LBD) from stroke between the ages of 31-71 years were studied...
February 15, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28211453/mechanism-of-partial-agonism-in-ampa-type-glutamate-receptors
#2
Hector Salazar, Clarissa Eibl, Miriam Chebli, Andrew Plested
Neurotransmitters trigger synaptic currents by activating ligand-gated ion channel receptors. Whereas most neurotransmitters are efficacious agonists, molecules that activate receptors more weakly-partial agonists-also exist. Whether these partial agonists have weak activity because they stabilize less active forms, sustain active states for a lesser fraction of the time or both, remains an open question. Here we describe the crystal structure of an α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor (AMPAR) ligand binding domain (LBD) tetramer in complex with the partial agonist 5-fluorowillardiine (FW)...
February 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/28198677/decipher-the-ancestry-of-the-plant-specific-lbd-gene-family
#3
Yimeng Kong, Peng Xu, Xinyun Jing, Longxian Chen, Laigeng Li, Xuan Li
BACKGROUND: Lateral Organ Boundaries Domain (LBD) genes arise from charophyte algae and evolve essential functions in land plants in regulating organ development and secondary metabolism. Although diverse plant species have been investigated to construct the phylogeny of LBD gene family, a detailed and reliable ancestry that characterizes their evolutionary patterns has not been revealed. RESULTS: We develop an improved bioinformatic method that allows robust detection of 431 LBD genes in 11 high-quality land plant genomes...
January 25, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28182972/defective-imitation-of-finger-configurations-in-patients-with-damage-in-the-right-or-left-hemispheres-an-integration-disorder-of-visual-and-somatosensory-information
#4
Manabu Okita, Takashi Yukihiro, Kenzo Miyamoto, Shu Morioka, Hideto Kaba
To explore the mechanism underlying the imitation of finger gestures, we devised a simple imitation task in which the patients were instructed to replicate finger configurations in two conditions: one in which they could see their hand (visual feedback: VF) and one in which they could not see their hand (non-visual feedback: NVF). Patients with left brain damage (LBD) or right brain damage (RBD), respectively, were categorized into two groups based on their scores on the imitation task in the NVF condition: the impaired imitation groups (I-LBD and I-RBD) who failed two or more of the five patterns and the control groups (C-LBD and C-RBD) who made one or no errors...
February 6, 2017: Brain and Cognition
https://www.readbyqxmd.com/read/28181678/safety-and-immunological-efficacy-of-a-dna-vaccine-encoding-the-androgen-receptor-ligand-binding-domain-ar-lbd
#5
Brian M Olson, Eric S Bradley, Thomas Sawicki, Weixiong Zhong, Erik A Ranheim, Jordan E Bloom, Viswa T Colluru, Laura E Johnson, Brian T Rekoske, Jens C Eickhoff, Douglas G McNeel
BACKGROUND: The androgen receptor (AR) is a key oncogenic driver of prostate cancer, and has been the primary focus of prostate cancer treatment for several decades. We have previously demonstrated that the AR is also an immunological target antigen, recognized in patients with prostate cancer, and targetable by means of vaccines in rodent models with delays in prostate tumor growth. The current study was performed to determine the safety and immunological efficacy of a GMP-grade plasmid DNA vaccine encoding the ligand-binding domain (LBD) of the AR, pTVG-AR...
February 9, 2017: Prostate
https://www.readbyqxmd.com/read/28181296/molecular-dynamics-studies-on-the-enzalutamide-resistance-mechanisms-induced-by-androgen-receptor-mutations
#6
Hongli Liu, Lingyan Wang, Jiaqi Tian, Jiazhong Li, Huanxiang Liu
The second-generation antiandrogen enzalutamide, targeting androgen receptor (AR), was approved to treat castration resistant prostate cancer (CRPC) in 2012. Its resistance was observed when it was in the clinical research stage. AR mutation is the main factor of enzalutamide resistance. AR F876L and F876L_T877A mutations were reported to switch enzalutamide from AR antagonist to agonist, but W741C cannot. There are various mutations in the ligand binding domain of androgen receptor (AR LBD), such as L701H, W741L, H874Y, T877A and M895T, if these mutations can lead to drug resistance problem or not is not known...
February 9, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28166880/repositioning-a-passive-patient-in-bed-choosing-an-ergonomically-advantageous-assistive-device
#7
Chava Weiner, Leonid Kalichman, Joseph Ribak, Deborah Alperovitch-Najenson
Repositioning of passive patients in bed creates health risks to the nursing personnel. Therefore, appropriate assistive devices should be used. Our aim was to find the optimal assistive device for reducing musculoskeletal load while moving a passive patient in bed. Torso kinematic inputs evaluated by the Lumbar Motion Monitor (LMM) and perceived load (Borg scale) were measured in female nurses performing 27 patient transfers [represented by a mannequin weighing 55 (12 nurses), 65 (24 nurses) and 75 kg (12 nurses) in bed] using a regular sheet, a sliding sheet and a carrier...
April 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/28166276/homovanillic-acid-and-5-hydroxyindole-acetic-acid-as-biomarkers-for-dementia-with-lewy-bodies-and-coincident-alzheimer-s-disease-an-autopsy-confirmed-study
#8
Satoru Morimoto, Masaki Takao, Hiroyuki Hatsuta, Yasushi Nishina, Tadashi Komiya, Renpei Sengoku, Yuta Nakano, Akiko Uchino, Hiroyuki Sumikura, Yuko Saito, Kazutomi Kanemaru, Shigeo Murayama
Dementia with Lewy bodies (DLB) and Alzheimer's disease (AD) are the two most common causes of dementia. Both pathologies often coexist, and AD patients with concomitant neocortical LB pathology (referred to as the Lewy body variant of AD) generally show faster cognitive decline and accelerated mortality relative to patients with pure AD. Thus, discriminating among patients with DLB, AD, and coincident DLB and AD is important in clinical practice. We examined levels of homovanillic acid (HVA), 5-hydroxyindole acetic acid (5-HIAA), tau, phosphorylated tau (p-tau), and beta-amyloid (Aβ) 1-42 in cerebrospinal fluid (CSF) to evaluate their viability as biomarkers to discriminate among different forms of dementia...
2017: PloS One
https://www.readbyqxmd.com/read/28165718/modification-of-the-orthosteric-ppar%C3%AE-covalent-antagonist-scaffold-yields-an-improved-dual-site-allosteric-inhibitor
#9
Richard Brust, Hua Lin, Jakob Fuhrmann, Alice Asteian, Theodore M Kamenecka, Douglas J Kojetin
GW9662 and T0070907 are widely used commercially available irreversible antagonists of peroxisome proliferator-activated receptor gamma (PPARγ). These antagonists covalently modify Cys285 located in an orthosteric ligand-binding pocket embedded in the PPARγ ligand-binding domain and are used to block binding of other ligands. However, we recently identified an alternate/allosteric ligand-binding site in the PPARγ LBD to which ligand binding is not inhibited by these orthosteric covalent antagonists. Here, we developed a series of analogs based on the orthosteric covalent antagonist scaffold with the goal of inhibiting both orthosteric and allosteric cellular activation of PPARγ by MRL20, an orthosteric agonist that also binds to an allosteric site...
February 16, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28165461/structure-of-the-homodimeric-androgen-receptor-ligand-binding-domain
#10
Marta Nadal, Stefan Prekovic, Nerea Gallastegui, Christine Helsen, Montserrat Abella, Karolina Zielinska, Marina Gay, Marta Vilaseca, Marta Taulès, Adriaan B Houtsmuller, Martin E van Royen, Frank Claessens, Pablo Fuentes-Prior, Eva Estébanez-Perpiñá
The androgen receptor (AR) plays a crucial role in normal physiology, development and metabolism as well as in the aetiology and treatment of diverse pathologies such as androgen insensitivity syndromes (AIS), male infertility and prostate cancer (PCa). Here we show that dimerization of AR ligand-binding domain (LBD) is induced by receptor agonists but not by antagonists. The 2.15-Å crystal structure of homodimeric, agonist- and coactivator peptide-bound AR-LBD unveils a 1,000-Å(2) large dimerization surface, which harbours over 40 previously unexplained AIS- and PCa-associated point mutations...
February 6, 2017: Nature Communications
https://www.readbyqxmd.com/read/28163118/local-failure-after-episcleral-brachytherapy-for-posterior-uveal-melanoma-patterns-risk-factors-and-management
#11
Claudine Bellerive, Hassan A Aziz, James Bena, Allan Wilkinson, John H Suh, Thomas Plesec, Arun D Singh
IMPORTANCE: A small percentage of patients with uveal melanoma will experience local recurrence following brachytherapy. An understanding of the recurrence patterns can improve early recognition and management of local treatment failure. OBJECTIVE: To evaluate the patterns, the risk factors and the management of recurrence following brachytherapy in patients with posterior uveal melanoma. DESIGN: Retrospective cohort study. SETTING: Multispecialty tertiary care center...
February 2, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28144231/non-genomic-actions-of-the-androgen-receptor-in-prostate-cancer
#12
REVIEW
Jacky K Leung, Marianne D Sadar
Androgen receptor (AR) is a validated drug target for prostate cancer based on its role in proliferation, survival, and metastases of prostate cancer cells. Unfortunately, despite recent improvements to androgen deprivation therapy and the advent of better antiandrogens with a superior affinity for the AR ligand-binding domain (LBD), most patients with recurrent disease will eventually develop lethal metastatic castration-resistant prostate cancer (CRPC). Expression of constitutively active AR splice variants that lack the LBD contribute toward therapeutic resistance by bypassing androgen blockade and antiandrogens...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28133847/fetal-megacystis-prediction-of-spontaneous-resolution-and-outcome
#13
F Fontanella, L Duin, P N Adama van Scheltema, T E Cohen-Overbeek, E Pajkrt, M Bekker, C Willekes, C J Bax, C M Bilardo
OBJECTIVES: To predict likelihood of spontaneous resolution during fetal life and postnatal outcome of fetal megacystis, diagnosed in all trimesters in pregnancy. METHODS: This was a national retrospective cohort study. Fetal megacystis was defined in the first trimester as a longitudinal bladder diameter (LBD) ≥ 7 mm, and in the 2(nd) and 3(rd) trimester as an enlarged bladder failing to empty during the entire extended ultrasound (US) examination. LBD and GA at resolution were investigated as of likelihood of resolution and of postnatal outcome, respectively...
January 30, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28130807/possible-effectiveness-of-low-dose-pregabalin-in-a-patient-suffering-from-lewy-body-disease-and-chronic-pruritus
#14
Katsuyuki Ukai
Many patients with Lewy body disease (LBD) complain of pain, although the detailed mechanism responsible for LBD-related pain remains to be clarified. Moreover, there does not appear to be any reports about LBD patients suffering from an itching sensation. In this report, the case of an LBD patient who experienced severe itching that persisted for over 6 months, which was treated successfully with low-dose pregabalin therapy, is described. This is the first study to report the effects of low-dose pregabalin, which has been used to treat LBD-related pain, to treat itching in a patient with LBD...
January 28, 2017: Psychogeriatrics: the Official Journal of the Japanese Psychogeriatric Society
https://www.readbyqxmd.com/read/28128331/identification-of-a-novel-selective-ppar%C3%AE-ligand-with-a-unique-binding-mode-and-improved-therapeutic-profile-in-vitro
#15
Wei Yi, Jingjing Shi, Guanguan Zhao, X Edward Zhou, Kelly Suino-Powell, Karsten Melcher, H Eric Xu
Thiazolidinediones (TZD) function as potent anti-diabetic drugs through their direct action on the nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ), but their therapeutic benefits are compromised by severe side effects. To address this concern, here we developed a potent "hit" compound, VSP-51, which is a novel selective PPARγ-modulating ligand with improved therapeutic profiles in vitro compared to the multi-billion dollar TZD drug rosiglitazone (Rosi). Unlike Rosi, VSP-51 is a partial agonist of PPARγ with improved insulin sensitivity due to its ability to bind PPARγ with high affinity without stimulating adipocyte differentiation and the expression of adipogenesis-related genes...
January 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28125680/allosteric-regulation-in-the-ligand-binding-domain-of-retinoic-acid-receptor%C3%AE
#16
Yassmine Chebaro, Serena Sirigu, Ismail Amal, Régis Lutzing, Roland H Stote, Cécile Rochette-Egly, Natacha Rochel, Annick Dejaegere
Retinoic acid (RA) plays key roles in cell differentiation and growth arrest through nuclear retinoic acid receptors (RARs), which are ligand-dependent transcription factors. While the main trigger of RAR activation is the binding of RA, phosphorylation of the receptors has also emerged as an important regulatory signal. Phosphorylation of the RARγ N-terminal domain (NTD) is known to play a functional role in neuronal differentiation. In this work, we investigated the phosphorylation of RARγ ligand binding domain (LBD), and present evidence that the phosphorylation status of the LBD affects the phosphorylation of the NTD region...
2017: PloS One
https://www.readbyqxmd.com/read/28123487/brain-derived-and-glial-cell-line-derived-neurotrophic-factor-fusion-protein-immobilization-to-laminin
#17
Baoxin Wang, Junjie Yuan, Jiafeng Xu, Xinwei Chen, Xinjiang Ying, Pin Dong
Damage to the recurrent laryngeal nerve often causes hoarseness, dyspnea, dysphagia, and sometimes asphyxia due to vocal cord paralysis which result in a reduction of quality of life. Brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) play critical roles in peripheral nerve regeneration. However, methods for efficiently delivering these molecules are lacking, which limits their use in clinical applications. The present study reports an effective strategy for targeting BDNF and GDNF to laminin by fusing the N-terminal domains of these molecules with agrin (NtA)...
January 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28117438/a-compound-based-proteomic-approach-discloses-15-ketoatractyligenin-methyl-ester-as-a-new-ppar%C3%AE-partial-agonist-with-anti-proliferative-ability
#18
Michele Vasaturo, Lorenzo Fiengo, Nunziatina De Tommasi, Lina Sabatino, Pamela Ziccardi, Vittorio Colantuoni, Maurizio Bruno, Carmen Cerchia, Ettore Novellino, Angelo Lupo, Antonio Lavecchia, Fabrizio Dal Piaz
Proteomics based approaches are emerging as useful tools to identify the targets of bioactive compounds and elucidate their molecular mechanisms of action. Here, we applied a chemical proteomic strategy to identify the peroxisome proliferator-activated receptor γ (PPARγ) as a molecular target of the pro-apoptotic agent 15-ketoatractyligenin methyl ester (compound 1). We demonstrated that compound 1 interacts with PPARγ, forms a covalent bond with the thiol group of C285 and occupies the sub-pocket between helix H3 and the β-sheet of the ligand-binding domain (LBD) of the receptor by Surface Plasmon Resonance (SPR), mass spectrometry-based studies and docking experiments...
January 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28114455/duration-and-pathologic-correlates-of-lewy-body-disease
#19
Jonathan Graff-Radford, Jeremiah Aakre, Rodolfo Savica, Bradley Boeve, Walter K Kremers, Tanis J Ferman, David T Jones, Kejal Kantarci, David S Knopman, Dennis W Dickson, Walter A Kukull, Ronald C Petersen
Importance: Although patients with dementia with Lewy bodies (DLB) have shorter disease duration than patients with Alzheimer disease dementia, little is known about which factors influence disease duration among patients with DLB. Objective: To identify pathologic correlates of disease duration in participants with Lewy body disease (LBD). Design, Setting, and Participants: This observational study, performed from September 1, 2005, to June 1, 2015, using the National Alzheimer's Coordinating Center database included 807 participants with transitional or diffuse LBD...
January 17, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28109294/probing-the-intermolecular-interactions-of-ppar%C3%AE-lbd-with-polyunsaturated-fatty-acids-and-their-anti-inflammatory-metabolites-to-infer-most-potential-binding-moieties
#20
Shalini Muralikumar, Umashankar Vetrivel, Angayarkanni Narayanasamy, Undurti N Das
BACKGROUND: PPARγ is an isoform of peroxisome proliferator-activated receptor (PPAR) belonging to a super family of nuclear receptors. PPARγ receptor is found to play a crucial role in the modulation of lipid and glucose homeostasis. Its commotion has been reported to play a significant role in a broad spectrum of diseases such as type 2 diabetes mellitus, inflammatory diseases, Alzheimer's disease, and in some cancers. Hence, PPARγ is an important therapeutic target. Polyunsaturated fatty acids (PUFAs) and their metabolites (henceforth referred to as bioactive lipids) are known to function as agonists of PPARγ...
January 21, 2017: Lipids in Health and Disease
keyword
keyword
30183
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"