keyword
MENU ▼
Read by QxMD icon Read
search

externalizing disorder

keyword
https://www.readbyqxmd.com/read/28334631/internalizing-and-externalizing-disorders-in-childhood-and-adolescence-a-latent-transition-analysis-using-alspac-data
#1
Eoin McElroy, Mark Shevlin, Jamie Murphy
BACKGROUND: Research examining the association between internalizing and externalizing dimensions of psychopathology has relied heavily on variable-centered analytical techniques. Person-centered methodologies complement the variable-centered approach, and may help explain the medium-to-large correlations that exist between higher order dimensions of psychopathology. What little person-centered research exists has been cross-sectional and utilized adult samples. The present study sought to take a person-centered approach to the modeling of psychiatric comorbidity during a key developmental phase; middle childhood through adolescence...
March 12, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28332952/dying-for-love-an-attachment-problem-with-some-perpetrator-introjects
#2
Valerie Sinason
This paper focuses on some problematic victim-perpetrator dynamics in psychotherapy with patients with Dissociative Identity Disorder where there has been longstanding multi-perpetrator organized abuse described, which also involves family members. Additionally, in this specific sample, there have been reported experiences of serious assaults from attachment figures in which the patient felt close to death. The clinical concern is expressed that only in the nearness of death is a connection felt to the attachment figure and this leads to extra suicidality in the patient and extra vulnerability to secondary traumatization for the therapist...
March 1, 2017: Journal of Trauma & Dissociation
https://www.readbyqxmd.com/read/28332438/quantitative-structure-activity-relationship-analysis-and-virtual-screening-studies-for-identifying-hdac2-inhibitors-from-known-hdac-bioactive-chemical-libraries
#3
H Pham-The, G Casañola-Martin, K Diéguez-Santana, N Nguyen-Hai, N T Ngoc, L Vu-Duc, H Le-Thi-Thu
Histone deacetylases (HDAC) are emerging as promising targets in cancer, neuronal diseases and immune disorders. Computational modelling approaches have been widely applied for the virtual screening and rational design of novel HDAC inhibitors. In this study, different machine learning (ML) techniques were applied for the development of models that accurately discriminate HDAC2 inhibitors form non-inhibitors. The obtained models showed encouraging results, with the global accuracy in the external set ranging from 0...
March 2017: SAR and QSAR in Environmental Research
https://www.readbyqxmd.com/read/28332171/sport-and-male-sexuality
#4
REVIEW
P Sgrò, L Di Luigi
The relationships between sport and sexuality in males are of great social and clinical interest, because of sports and motor activities that highly promote social and sexual relationships. Even if few literature exist, two main questions should be taken into account: whether and how physical exercise and sport positively or negatively influence sexual health and behavior and/or whether and how sexual behavior may affect a sub-sequent sport performance. Physical exercise and sport per se can influence, positively or negatively, the hypothalamic-pituitary-testicular axis function and, consequently, the individual's reproductive and/or sexual health...
March 22, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28331946/-technique-of-proton-and-phosphorous-mr-spectroscopy
#5
M Backens
CLINICAL/METHODICAL ISSUE: Magnetic resonance spectroscopy (MRS) is an important non-invasive method that can reveal the concentration and spatial distribution of particular biochemically relevant tissue metabolites. STANDARD RADIOLOGICAL METHODS: Proton MRS is routinely applicable in the clinical setting providing good quality results even with a moderate magnetic field strength of 1.5 T. Relative values of metabolite concentrations are mostly used for the assessment of metabolic disorders...
March 22, 2017: Der Radiologe
https://www.readbyqxmd.com/read/28328148/long-term-follow-up-study-of-community-based-patients-receiving-xr-ntx-for-opioid-use-disorders
#6
Arthur Robin Williams, Vincent Barbieri, Kaitlyn Mishlen, Frances R Levin, Edward V Nunes, John J Mariani, Adam Bisaga
BACKGROUND AND OBJECTIVES: Extended-release naltrexone (XR-NTX) is FDA-approved to prevent relapse in patients with Opioid Use Disorder. However little is known about long-term use among community-based outpatients. METHODS: Retrospective chart review and long-term follow-up survey among individuals (N = 168) who entered an outpatient XR-NTX trial between 2011 and 2015, during which participants were offered three monthly injections of XR-NTX at no cost. The survey consisted of 35 questions covering a total of four domains: (1) substance use; (2) treatment continuation; (3) barriers; and (4) attitudes...
March 22, 2017: American Journal on Addictions
https://www.readbyqxmd.com/read/28326963/the-stillbirth-classification-system-for-the-safe-passage-study
#7
Theonia K Boyd, Colleen A Wright, Hein J Odendaal, Amy J Elliott, Mary Ann Sens, Rebecca D Folkerth, Drucilla J Roberts, Hannah C Kinney
Objective Describe the classification system for assigning the cause of stillbirth in the Safe Passage Study, an international, multi-institutional, prospective analysis conducted by the NIAAA/NICHD-funded Prenatal Alcohol in SIDS and Stillbirth (PASS) Research Network. The study mission is to determine the role of prenatal alcohol and/or cigarette smoke exposure in adverse pregnancy outcomes, including stillbirth, in a high-risk cohort of 12,000 maternal/fetal dyads. Methods The PASS Network classification system is based upon 5 "sites of origin" for cause of stillbirth, further subdivided into mechanism subcategories; both are employed to assign an ultimate cause of death...
March 2017: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/28326463/relationship-between-selenium-lead-and-mercury-in-red-blood-cells-of-saudi-autistic-children
#8
Afaf El-Ansary, Geir Bjørklund, Alexey A Tinkov, Anatoly V Skalny, Hussain Al Dera
Autism spectrum disorder (ASD) is a neurodevelopmental disorder that can cause significant social, communication and behavioral challenges. Environmental contribution to ASD is due in large part to the sensitivity of the developing brain to external exposures such as lead (Pb), and mercury (Hg) as toxic heavy metals or due to a poor detoxification ability as the phenotype of this disorder. Selenium (Se) as an antioxidant element that counteracts the neurotoxicity of Hg, and Pb, presumably through the formation of nontoxic complexes...
March 21, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28326047/preventing-internalizing-problems-in-young-children-a-randomized-controlled-trial-of-the-feelings-and-friends-year-3-program-with-a-motor-skills-component
#9
Ruhamah G Tennant, Katie K Martin, Rosanna Rooney, Sharinaz Hassan, Robert T Kane
Anxiety and depression are common mental health problems experienced by children in Australia. The impact of these internalizing disorders is pervasive, affecting many areas of life. By the time problems have been detected in children they can be severe in nature and harder to treat. Hence, early intervention is of utmost importance. Despite the existence of numerous prevention programs for children, there is limited empirical evidence for a program that has an impact on symptoms of both anxiety and depression...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28324239/mtdna-maintenance-defects-syndromes-and-genes
#10
Carlo Viscomi, Massimo Zeviani
A large group of mitochondrial disorders, ranging from early-onset pediatric encephalopathic syndromes to late-onset myopathy with chronic progressive external ophthalmoplegia (CPEOs), are inherited as Mendelian disorders characterized by disturbed mitochondrial DNA (mtDNA) maintenance. These errors of nuclear-mitochondrial intergenomic signaling may lead to mtDNA depletion, accumulation of mtDNA multiple deletions, or both, in critical tissues. The genes involved encode proteins belonging to at least three pathways: mtDNA replication and maintenance, nucleotide supply and balance, and mitochondrial dynamics and quality control...
March 21, 2017: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/28323136/self-reported-knee-pain-and-disability-among-healthy-individuals-reference-data-and-factors-associated-with-the-knee-injury-and-osteoarthritis-outcome-score-koos-and-koos-child
#11
Jennifer N Baldwin, Marnee J McKay, Claire E Hiller, Niamh Moloney, Elizabeth J Nightingale, Joshua Burns
OBJECTIVE: To develop normative reference data for the Knee injury and Osteoarthritis Outcome Score (KOOS) and KOOS-Child, as well as investigate socio-demographic, psychological and physical factors associated with knee pain and disability among healthy adults. METHOD: The KOOS or KOOS-Child (each containing five subscales) was administered to participants aged 8-101 years within the 1000 Norms Project, an observational study of 1000 self-reported healthy individuals...
March 16, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28322591/insight-into-the-structural-requirements-of-pyrimidine-based-phosphodiesterase-10a-pde10a-inhibitors-by-multiple-validated-3d-qsar-approaches
#12
A K Halder, S A Amin, T Jha, S Gayen
Schizophrenia is a complex disorder of thinking and behaviour (0.3-0.7% of the population is affected). The over-expression of phosphodiesterase 10A (PDE10A) enzyme may be a potential target for schizophrenia and Huntington's disease. Because 3D QSAR analysis is one of the most frequently used modelling techniques, in the present study, five different 3D QSAR tools, namely CoMFA, CoMSIA, kNN-MFA, Open3DQSAR and topomer CoMFA methods, were used on a dataset of pyrimidine-based PDE10A inhibitors. All developed models were validated internally and externally...
March 21, 2017: SAR and QSAR in Environmental Research
https://www.readbyqxmd.com/read/28321642/circadian-rhythm-dysregulation-in-bipolar-spectrum-disorders
#13
REVIEW
Lauren B Alloy, Tommy H Ng, Madison K Titone, Elaine M Boland
PURPOSE OF REVIEW: We review recent evidence for circadian rhythm dysregulation in bipolar spectrum disorders (BSDs). We examine evidence for endogenous abnormalities in the biological clock and disruptions in the external entrainment of circadian rhythms in BSDs. We also address whether circadian dysregulation provides vulnerability to onset of BSD and evidence for a new integration of reward and circadian dysregulation in BSD. RECENT FINDINGS: Relative circadian phase delay (e...
April 2017: Current Psychiatry Reports
https://www.readbyqxmd.com/read/28319814/time-specific-and-cumulative-effects-of-exposure-to-parental-externalizing-behavior-on-risk-for-young-adult-alcohol-use-disorder
#14
Alexis C Edwards, Sara L Lönn, Katherine J Karriker-Jaffe, Jan Sundquist, Kenneth S Kendler, Kristina Sundquist
BACKGROUND: Previous studies indicate that parental externalizing behavior (EB) is a robust risk factor for alcohol use disorder (AUD) in their children, and that this is due to both inherited genetic liability and environmental exposure. However, it remains unclear whether the effects of exposure to parental EB vary as a function of timing and/or chronicity. METHODS: We identified biological parents with an alcohol use disorder, drug abuse, or criminal behavior, during different periods of their child's upbringing, using Swedish national registries...
March 8, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28319024/the-prostatic-utricle-an-under-recognized-condition-resulting-in-significant-morbidity-in-boys-with-both-hypospadias-and-normal-external-genitalia
#15
Austin G Hester, Stanley J Kogan
INTRODUCTION: Pediatric presentations of a prostatic utricle have received only scant attention. Though recognized with increased frequency in boys with hypospadias, little is described about their incidence and potential for morbidity in boys with normal external genitalia. METHODS: We initially reviewed a cohort of 64 patients with hypospadias seen over a 3-year period to determine the frequency of investigative lower urinary tract studies and utricle identification...
March 1, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28318658/sudden-death-in-athletes
#16
Domenico Corrado, Alessandro Zorzi
Competitive sports activity is associated with an increased risk of sudden cardiovascular death (SCD) in adolescents and young adults with clinically silent cardiovascular disorders. While in middle-aged/senior athletes atherosclerotic coronary artery disease accounts for the vast majority of SCDs, in young athletes the spectrum of substrates is wider and includes inherited (cardiomyopathies) and congenital (anomalous origin of coronary arteries) structural heart diseases. Inherited ion channel diseases have been implicated in SCDs occurring with an apparently normal heart at autopsy...
March 10, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28318338/latent-class-profiles-of-anxiety-symptom-trajectories-from-preschool-through-school-age
#17
Sarah J Kertz, Chad Sylvester, Rebecca Tillman, Joan L Luby
Anxiety typically arises early in childhood and decreases during school age. However, little is known about the earlier developmental course of anxiety in preschool, especially in at risk children, posing a clinically important problem. Given that anxiety in youth has a chronic course for some and also predicts later development of other mental health problems, it is important to identify factors early in development that may predict chronic anxiety symptoms. At-risk children (oversampled for depression) and caregivers completed 6 assessment waves beginning at preschool age (between 3-5...
March 20, 2017: Journal of Clinical Child and Adolescent Psychology
https://www.readbyqxmd.com/read/28315366/amygdala-functional-connectivity-is-associated-with-locus-of-control-in-the-context-of-cognitive-aging
#18
Ping Ren, Mia Anthony, Benjamin P Chapman, Kathi Heffner, Feng Lin
Locus of control (LOC) measures the extent to which individuals perceive control over their lives. Those with a more "internal" LOC feel self-sufficient and able to determine important aspects of their own future, while those with a more "external" LOC feel that their lives are governed by events beyond their control. Reduced internal LOC and increased external LOC have been found in cognitive disorders, but the neural substrates of these control perceptions are yet unknown. In the present study, we explored the relationship between amygdala functional connectivity and LOC in 18 amnestic mild cognitive impairment (MCI) and age-, sex-, and education-matched, 22 cognitively healthy controls (HC)...
March 14, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28314554/an-evaluation-of-the-absolute-and-relative-stability-of-alexithymia-over-11years-in-a-finnish-general-population
#19
A Hiirola, S Pirkola, M Karukivi, N Markkula, R M Bagby, M Joukamaa, A Jula, E Kronholm, S Saarijärvi, J K Salminen, J Suvisaari, G Taylor, A K Mattila
OBJECTIVE: We investigated if alexithymia, a personality construct with difficulties in emotional processing, is stable in the general population. METHODS: Altogether 3083 unselected subjects aged 30 and older in Finland completed the 20-item Toronto Alexithymia Scale (TAS-20) in the longitudinal Health 2000 and Health 2011 general population surveys (BRIF8901). The stability of alexithymia at the 11-year follow-up was assessed with t-tests, correlations, and separate linear regression models with base-line and follow-up age, gender, marital status, education, and 12-month depressive and anxiety disorders as confounders...
April 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28314521/orienting-reaction-may-help-recognition-of-patients-with-psychogenic-nonepileptic-seizures
#20
Murat Yalçın, Evrim Tellioğlu, Ayşegül Gündüz, Mine Özmen, Naz Yeni, Çiğdem Özkara, Meral E Kiziltan
OBJECTIVE: Psychogenic nonepileptic seizures (PNES) are abrupt, paroxysmal changes in behavior or consciousness that may phenomenologically resemble epileptic seizures. Given the known association between anxiety and PNES, we hypothesized that in these subjects there may be evidence that the nervous system is hypersensitive to external stimuli. We aimed to test our hypothesis by means of the auditory startle reaction (ASR). By investigating ASR, we also had the opportunity to test presence of orienting reaction, which is generally defined as the second phase of response after the auditory stimulus, with longer latency...
March 14, 2017: Neurophysiologie Clinique, Clinical Neurophysiology
keyword
keyword
30181
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"