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https://www.readbyqxmd.com/read/25575340/indacaterol-a-once-daily-beta2-agonist-versus-twice-daily-beta%C3%A2-agonists-or-placebo-for-chronic-obstructive-pulmonary-disease
#1
REVIEW
James B Geake, Eli J Dabscheck, Richard Wood-Baker, Christopher J Cates
BACKGROUND: Indacaterol is an inhaled long-acting beta2-agonist that is administered once daily and has been investigated as a treatment for chronic obstructive pulmonary disease (COPD). Four different doses have been investigated (75 mcg, 150 mcg, 300 mcg and 600 mcg). The relative effects of different doses of once-daily indacaterol in the management of patients with COPD are uncertain. OBJECTIVES: To compare the efficacy and safety of indacaterol versus placebo and alternative twice-daily long-acting beta2-agonists for the treatment of patients with stable COPD...
2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/21850666/aerosol-tribocharging-and-its-relation-to-the-deposition-of-oxis%C3%A2-turbuhaler%C3%A2-in-the-electrical-next-generation-impactor
#2
Susan Hoe, Paul M Young, Daniela Traini
Although there have been published electrostatic characterisation studies of drug-only Turbuhaler® and lactose carrier-drug formulations, there has not been an investigation into spheronised agglomerates containing micronised lactose and eformoterol, such as in Oxis® Turbuhaler®. Ten doses of Oxis® (12 µ g eformoterol) were dispersed into an electrical next generation impactor (eNGI) in a single run, and runs were conducted in triplicate to determine the aerosol performance and aerosol charge distribution at flow rates of 30, 60 and 90 L/min...
December 2011: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/21054671/sodium-cromoglycate-and-eformoterol-attenuate-sensitivity-and-reactivity-to-inhaled-mannitol-in-subjects-with-bronchiectasis
#3
RANDOMIZED CONTROLLED TRIAL
Peter J Briffa, Sandra D Anderson, Deborah L Burton, Iven H Young
BACKGROUND AND OBJECTIVE: Dry powder mannitol has the potential to be used to enhance clearance of mucus in subjects with bronchiectasis. A reduction in FEV1 has been recorded in some subjects with bronchiectasis after inhaling mannitol. The aim of this study was to investigate if pre-medicating with either sodium cromoglycate (SCG) or eformoterol could inhibit this reduction in FEV1. METHODS: A double-blind, placebo-controlled, randomized cross-over study was conducted...
January 2011: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/20576419/beneficial-effect-of-inhaled-mannitol-and-cough-in-asthmatics-with-mucociliary-dysfunction
#4
Evangelia Daviskas, Sandra D Anderson, Stefan Eberl, Iven H Young
Asthmatics with overproduction of mucus that is viscous and sticky have impaired mucociliary clearance (MCC) leading to mucus plugs, and airway obstruction. Inhaled mannitol improves mucus clearance in other hypersecretory diseases. This study investigated the effect of mannitol and cough in asthmatics with mucociliary dysfunction. Seven stable asthmatics, age 52 ± 20 yr, lifelong non-smokers, without the diagnosis of bronchiectasis, with chronic cough and sputum production, treated with inhaled corticosteroids participated in the study...
November 2010: Respiratory Medicine
https://www.readbyqxmd.com/read/20158286/prospective-drug-safety-monitoring-using-the-uk-primary-care-general-practice-research-database-theoretical-framework-feasibility-analysis-and-extrapolation-to-future-scenarios
#5
Saga Johansson, Mari-Ann Wallander, Francisco J de Abajo, Luis Alberto García Rodríguez
BACKGROUND: Post-launch drug safety monitoring is essential for the detection of adverse drug signals that may be missed during preclinical trials. Traditional methods of postmarketing surveillance such as spontaneous reporting have intrinsic limitations, many of which can be overcome by the additional application of structured pharmacoepidemiological approaches. However, further improvement in drug safety monitoring requires a shift towards more proactive pharmacoepidemiological methods that can detect adverse drug signals as they occur in the population...
March 1, 2010: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/17875056/inhaled-mannitol-changes-the-sputum-properties-in-asthmatics-with-mucus-hypersecretion
#6
Evangelia Daviskas, Sandra D Anderson, Iven H Young
BACKGROUND AND OBJECTIVES: Most asthmatics with mucus hypersecretion have difficulty in clearing their secretions so that mucus plugs and airway obstruction are commonly present. Inhaled mannitol facilitates clearance of mucus. This study investigated the changes in the physical properties of sputum in response to mannitol in asthmatics with chronic cough and sputum production. METHOD: Sputum was collected from 12 asthmatics (26-73 year), lifelong non-smokers, at baseline, after eformoterol (24 mug) and after mannitol on each of four visits...
September 2007: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/17803747/some-pharmacodynamic-effects-of-eformoterol-in-the-horse
#7
RANDOMIZED CONTROLLED TRIAL
G J B Ladaga, F P Lezica, G Ferraro, G A De Erausquin
No abstract text is available yet for this article.
October 2007: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/16279260/eformoterol-n-of-1-trials-in-chronic-obstructive-pulmonary-disease-poorly-reversible-to-salbutamol
#8
RANDOMIZED CONTROLLED TRIAL
B J Smith, S L Appleton, A J Veale, H J McElroy, D Veljkovic, L Saccoia
AIMS: Benefits of long acting beta 2 agonists are unclear for severe chronic obstructive pulmonary disease (COPD) patients with poor response to short acting bronchodilators. We aimed to evaluate 1) effects of eformoterol in such patients using a 'n-of-1' double crossover study design, and 2) aggregate data as a double-blind, double crossover randomized control trial. METHODS: Subjects with forced expiratory volume in one second (FEV1) < 60% predicted, and poor response to short acting bronchodilators were studied six times over 18 weeks...
2004: Chronic Respiratory Disease
https://www.readbyqxmd.com/read/15994387/traditional-and-patient-centred-outcomes-with-three-classes-of-asthma-medication
#9
RANDOMIZED CONTROLLED TRIAL
C R Jenkins, F C K Thien, J R Wheatley, H K Reddel
Lung function is commonly used as the primary endpoint in asthma clinical trials, but it may not reflect changes which are important to patients. The present study compared changes in, and relationships between, traditional and patient-centred end-points during treatment with three classes of asthma medication. Subjects with mild-to-moderate asthma were randomised to double-blind, double-dummy crossover treatment with eformoterol 12 microg b.i.d. or montelukast 10 mg q.d., then single-blind treatment with fluticasone 250 microg b...
July 2005: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/15624197/changes-in-prescribing-of-inhaled-corticosteroids-1999-2002-in-scotland
#10
Anne C Boyter, Douglas T Steinke
PURPOSE: To investigate the trend in prescribing of inhaled corticosteroids and general practitioner (GP) consultations for respiratory diseases. METHODS: A longitudinal observation study of all prescriptions, from primary care, for inhaled corticosteroids dispensed in Scotland from January 1999 to May 2002 was undertaken. The main outcome measures were the trends in prescribing of inhaled corticosteroids and GP consultations for respiratory diseases. RESULTS AND CONCLUSIONS: The prescribing of all inhaled corticosteroids has risen over the study period...
March 2005: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/15120010/in-vitro-intra-and-inter-inhaler-flow-rate-dependent-dosage-emission-from-a-combination-of-budesonide-and-eformoterol-in-a-dry-powder-inhaler
#11
W Tarsin, K H Assi, H Chrystyn
Some dry powder inhalers have profound inhalation flow rate-dependent dosage emission, and it has been suggested that there are links between the in vitro emitted dose, total lung deposition, and subsequent clinical response. We have measured the in vitro dosage delivery for a combination of budesonide and eformoterol in a new version of the Turbuhaler. At inhalation flow rates of 30, 60, and 90 Lmin(-1), the total dose emission for 10 separate inhalations from each of six inhalers was determined. The aerodynamic characteristics of the emitted dose using inhalation flow rates of 28...
2004: Journal of Aerosol Medicine: the Official Journal of the International Society for Aerosols in Medicine
https://www.readbyqxmd.com/read/14998381/eformoterol-turbohaler-compared-with-salmeterol-by-dry-powder-inhaler-in-asthmatic-children-not-controlled-on-inhaled-corticosteroids
#12
RANDOMIZED CONTROLLED TRIAL
Paul Everden, Malcolm Campbell, Chris Harnden, Hugh McGoldrick, Bavesh Bodalia, Victoria Manion, Sarah Reynia
The aim of the study was to compare the efficacy of the inhaled long-acting beta2-agonists eformoterol and salmeterol when added to existing inhaled corticosteroid (ICS) therapy in symptomatic asthmatic children. This randomized, 12-week, parallel-group study, performed in a primary care setting, included 156 children and adolescents (aged 6-17 years) with moderate persistent asthma. Patients were randomized to open-label eformoterol (Oxis) Turbohaler 9 microg (delivered dose) or salmeterol Accuhaler 50 microg, both b...
February 2004: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/14725487/arformoterol-r-r-eformoterol-r-r-formoterol-arformoterol-tartrate-eformoterol-sepracor-formoterol-sepracor-r-r-eformoterol-r-r-formoterol
#13
REVIEW
(no author information available yet)
Sepracor in the US is developing arformoterol [R,R-formoterol], a single isomer form of the beta(2)-adrenoceptor agonist formoterol [eformoterol]. This isomer contains two chiral centres and is being developed as an inhaled preparation for the treatment of respiratory disorders. Sepracor believes that arformoterol has the potential to be a once-daily therapy with a rapid onset of action and a duration of effect exceeding 12 hours. In 1995, Sepracor acquired New England Pharmaceuticals, a manufacturer of metered-dose and dry powder inhalers, for the purpose of preparing formulations of levosalbutamol and arformoterol...
2004: Drugs in R&D
https://www.readbyqxmd.com/read/14719995/adverse-effects-of-beta-agonists-are-they-clinically-relevant
#14
REVIEW
Michael J Abramson, Julia Walters, E Haydn Walters
Inhaled beta(2)-adrenoceptor agonists (beta(2)-agonists) are the most commonly used asthma medications in many Western countries. Minor adverse effects such as palpitations, tremor, headache and metabolic effects are predictable and dose related. Time series studies suggested an association between the relatively nonselective beta-agonist fenoterol and asthma deaths. Three case-control studies confirmed that among patients prescribed fenoterol, the risk of death was significantly elevated even after controlling for the severity of asthma...
2003: American Journal of Respiratory Medicine: Drugs, Devices, and Other Interventions
https://www.readbyqxmd.com/read/12917905/long-acting-beta-agonists-versus-theophylline-for-maintenance-treatment-of-asthma
#15
REVIEW
L Shah, A J Wilson, P G Gibson, J Coughlan
BACKGROUND: Theophylline and long acting beta-2 agonists are bronchodilators used for the management of persistent asthma symptoms, especially nocturnal asthma. They represent different classes of drug with differing side-effect profiles. OBJECTIVES: To assess the comparative efficacy, safety and side-effects of long-acting beta-2 agonists and theophylline in the maintenance treatment of asthma. SEARCH STRATEGY: Randomised, controlled trials (RCTs) were identified using the Cochrane Airways Group register...
2003: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/12542893/tocolytic-activity-of-formoterol-against-premature-delivery-in-mice
#16
COMPARATIVE STUDY
N Shinkai, K Takasuna, S Takayama
The tocolytic activity of formoterol (eformoterol), a long-acting potent beta(2)-adrenoceptor agonist, was assessed in pregnant mice, with determination of uterine effects on the 15th and 16th days of gestation. For examination in the lipopolysaccharide-induced premature delivery model, osmotic pumps filled with formoterol or saline solution were implanted subcutaneously under the back skin. The mice were sacrificed 18-20 h thereafter, and the numbers of fetuses in the uteri and the newborn were counted. The uteri, amniotic membranes and placenta were also rapidly removed for determination of IL-6 concentrations...
December 2002: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/12200524/early-asthma-control-and-maintenance-with-eformoterol-following-reduction-of-inhaled-corticosteroid-dose
#17
RANDOMIZED CONTROLLED TRIAL
D Price, D Dutchman, A Mawson, B Bodalia, S Duggan, P Todd
BACKGROUND: Previous studies have indicated the benefits of adding long acting beta(2) agonists to inhaled corticosteroids in the maintenance treatment of moderate to severe asthma. The effects of adding eformoterol to corticosteroids on asthma control and exacerbations in patients with mild to moderate asthma were studied. METHODS: After a run in period of 7-14 days on existing medication, 663 symptomatic patients were randomised to receive budesonide Turbohaler 400 microg twice daily together with either eformoterol Turbohaler 9 micro g (delivered dose) or placebo twice daily...
September 2002: Thorax
https://www.readbyqxmd.com/read/12000004/cost-effectiveness-of-eformoterol-turbohaler-versus-salmeterol-accuhaler-in-children-with-symptomatic-asthma
#18
RANDOMIZED CONTROLLED TRIAL
P Everden, A Lloyd, J Hutchinson, J Plumb
We conducted an economic evaluation in a UK setting based on a 12-week prospective randomized open-label parallel-group comparison of eformoterol Turbohaler 12 microg b. i.d. with salmeterol Accuhaler 50 microg b. i.d. in children aged 6-17 with symptomatic asthma receiving inhaled corticosteroids and short-acting beta2-agonists. The principal effectiveness measure was percentage of symptom-free days with no short-acting beta2-agonist use during the study period. Asthma-related medication, unscheduled physician contacts and hospitalizations were collected prospectively and cost to the UK NHS calculated using year 2,000 prices...
April 2002: Respiratory Medicine
https://www.readbyqxmd.com/read/11791690/in-vitro-aerosol-performance-and-dose-uniformity-between-the-foradile-aerolizer-and-the-oxis-turbuhaler
#19
COMPARATIVE STUDY
N Y Chew, H K Chan
Dry powder inhalers for eformoterol fumarate dihydrate, a long-acting beta-2 agonist for bronchodilation, are currently available as the Foradile Aerolizer and the Oxis Turbuhaler. The two products are different in the formulation, the aerosol production mechanism, and the device resistance to air flow. These disparities are likely to lead to different aerosol characteristics. Our objective was to compare the in vitro performance of these two inhalers in producing eformoterol aerosols. Emitted dose uniformity was measured using a sampling apparatus described in the British Pharmacopaeia...
2001: Journal of Aerosol Medicine: the Official Journal of the International Society for Aerosols in Medicine
https://www.readbyqxmd.com/read/10999872/a-randomised-controlled-trial-of-short-term-growth-and-collagen-turnover-in-asthmatics-treated-with-inhaled-formoterol-and-budesonide
#20
RANDOMIZED CONTROLLED TRIAL
C Heuck, L Heickendorff, O D Wolthers
AIMS: To determine effects on short term growth and collagen turnover of adding formoterol (Eformoterol) to half the glucocorticoid dose in children with asthma, treated with inhaled budesonide (Pulmicort Turbuhaler). DESIGN: A randomised double blind, placebo controlled crossover study with two six-week periods. SETTING: Outpatient clinic in secondary referral centre. SUBJECTS: A total of 27 prepubertal children aged 6-13 years...
October 2000: Archives of Disease in Childhood
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