Nadezda V Andrianova, Anna A Brezgunova, Marina I Buyan, Ciara I Makievskaya, Andrey I Buyan, Kseniia S Cherkesova, Irina B Pevzner, Ljubava D Zorova, Dmitry B Zorov, Egor Y Plotnikov, Vasily A Popkov
The positive effects of female sex hormones, particularly estradiol and progesterone, have been observed in treatment of various pathologies. Acute kidney injury (AKI) is a common condition in hospitalized patients in which the molecular mechanisms of hormone action are poorly characterized. In this study, we investigated the influence of estradiol and progesterone on renal cells during ischemic injury. We performed both in vivo experiments on female and male rats and in vitro experiments on renal tubular cells (RTCs) obtained from the kidneys of intact animals of different sexes...
March 9, 2024: International Journal of Molecular Sciences