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https://www.readbyqxmd.com/read/29352361/the-modified-ravitch-approach-for-the-management-of-severe-anterior-flail-chest-with-bilateral-sternochondral-dislocations-a-case-report
#1
Gabriel Estremera, Ellen Chieko Omi, Eduardo Smith-Singares
The management of flail chest continues to evolve as scientific evidence and surgical experience accumulates. Flail chest injuries that span the sternum present a rare and complicated injury pattern that can be challenging to manage both medically and surgically. Our patient is a 69-year-old involved in a high-speed motor vehicle crash with respiratory failure secondary to an anterior flail chest. Tomographic examination confirmed a sternal fracture with bilateral sternochondral dislocations and multiple rib fractures...
January 19, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29352277/influence-of-early-stress-on-memory-reconsolidation-implications-for-post-traumatic-stress-disorder-treatment
#2
Hélène Villain, Aïcha Benkahoul, Philippe Birmes, Barbara Ferry, Pascal Roullet
Post-traumatic stress disorder (PTSD) is a common consequence of exposure to a life-threatening event. Currently, pharmacological treatments are limited by high rates of relapse, and novel treatment approaches are needed. We have recently demonstrated that propranolol, a β-adrenergic antagonist, inhibited aversive memory reconsolidation in animals. Following this, in an open-label study 70% of patients with PTSD treated with propranolol during reactivation of traumatic memory exhibited full remission. However, the reason why 30% of these patients did not respond positively to propranolol treatment is still unclear...
2018: PloS One
https://www.readbyqxmd.com/read/29351989/iterative-random-forests-to-discover-predictive-and-stable-high-order-interactions
#3
Sumanta Basu, Karl Kumbier, James B Brown, Bin Yu
Genomics has revolutionized biology, enabling the interrogation of whole transcriptomes, genome-wide binding sites for proteins, and many other molecular processes. However, individual genomic assays measure elements that interact in vivo as components of larger molecular machines. Understanding how these high-order interactions drive gene expression presents a substantial statistical challenge. Building on random forests (RFs) and random intersection trees (RITs) and through extensive, biologically inspired simulations, we developed the iterative random forest algorithm (iRF)...
January 19, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29351816/effects-of-gut-derived-endotoxin-on-anxiety-like-and-repetitive-behaviors-in-male-and-female-mice
#4
Christopher T Fields, Benoit Chassaing, Alexandra Castillo-Ruiz, Remus Osan, Andrew T Gewirtz, Geert J de Vries
BACKGROUND: Gut dysbiosis is observed in several neuropsychiatric disorders exhibiting increases in anxiety behavior, and recent work suggests links between gut inflammation and such disorders. One source of this inflammation may be lipopolysaccharide (LPS), a toxic component of gram-negative bacteria. Here, we (1) determine whether oral gavage of LPS, as a model of gut-derived endotoxemia, affects anxiety-like and/or repetitive behaviors; (2) test whether these changes depend on TLR4 signaling; and (3) test the extent to which gut-derived endotoxin and TLR4 antagonism affects males and females differently...
January 19, 2018: Biology of Sex Differences
https://www.readbyqxmd.com/read/29351363/carers-experiences-of-home-enteral-feeding-a-survey-exploring-medicines-administration-challenges-and-strategies
#5
D Alsaeed, D Furniss, A Blandford, F Smith, M Orlu
WHAT IS KNOWN AND OBJECTIVES: The use of enteral tube feeding at home is becoming more widespread, with patients ranging in age and diseases. Dysphagia and swallowing difficulties can compromise nutritional intake and the administration of oral medications, affecting therapeutic outcomes negatively. Carers' experiences of medicines administration and medicines optimization have not been explored fully. The objectives of this study were to identify issues carers experience in medicines administration; the strategies they have developed to cope; and suggestions to improve the medicines administration process...
January 19, 2018: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29351280/a-generic-framework-for-individual-based-modelling-and-physical-biological-interaction
#6
Asbjørn Christensen, Patrizio Mariani, Mark R Payne
The increased availability of high-resolution ocean data globally has enabled more detailed analyses of physical-biological interactions and their consequences to the ecosystem. We present IBMlib, which is a versatile, portable and computationally effective framework for conducting Lagrangian simulations in the marine environment. The purpose of the framework is to handle complex individual-level biological models of organisms, combined with realistic 3D oceanographic model of physics and biogeochemistry describing the environment of the organisms without assumptions about spatial or temporal scales...
2018: PloS One
https://www.readbyqxmd.com/read/29350918/entrapped-styrene-butadiene-polymer-chains-by-sol-gel-derived-silica-nanoparticles-with-hierarchical-raspberry-structures
#7
Sankar Raman Vaikuntam, Klaus Werner Stöckelhuber, Eshwaran Subramani Bhagavatheswaran, Sven Wiessner, Ulrich Scheler, Kay Saalwaechter, Petr Formanek, Gert Heinrich, Amit Das
A sol-gel transformation of liquid silica precursor to solid silica particles was carried out in a one pot synthesis way where a solution of styrene butadiene elastomer (S-SBR) was present. The composites, thus produced, offered remarkable improvements of mechanical and dynamic mechanical performances as compared with precipitated silica. The morphological analysis reveals that the alkoxy-based silica particles resemble a raspberry structure when the synthesis of the silica was carried out in presence of polymer molecules and represent a much more open silica-network structure...
January 19, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29350728/dual-chain-extension-effect-and-antibacterial-properties-of-biomolecules-interleaved-within-ldh-dispersed-into-pbs-by-in-situ-polymerization
#8
Grazia Totaro, Laura Sisti, Annamaria Celli, Irene Aloisio, Diana Di Gioia, Adam A Marek, Vincent Verney, Fabrice Leroux
Nanocomposites based on poly(butylene succinate) (PBS) and hydrotalcite-type anionic clays (HTs) organo-modified with biomolecules characterized by antibacterial and/or antioxidant activities, such as l-ascorbic acid (ASA), phloretic acid (HPP), l-tyrosine (TYR) and l-tryptophan (TRP), have been prepared by in situ polymerization. From XRD analysis and rheology experiments in a molten polymer state, intercalated HT hybrid platelets acting here as a hybrid filler are found to be well dispersed into polymers while providing a chain extension effect on PBS...
January 19, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29350516/time-dependent-density-functional-theory-for-open-systems-and-its-applications
#9
Shuguang Chen, YanHo Kwok, GuanHua Chen
Photovoltaic devices, electrochemical cells, catalysis processes, light emitting diodes, scanning tunneling microscopes, molecular electronics, and related devices have one thing in common: open quantum systems where energy and matter are not conserved. Traditionally quantum chemistry is confined to isolated and closed systems, while quantum dissipation theory studies open quantum systems. The key quantity in quantum dissipation theory is the reduced system density matrix. As the reduced system density matrix is an O(M! × M!) matrix, where M is the number of the particles of the system of interest, quantum dissipation theory can only be employed to simulate systems of a few particles or degrees of freedom...
January 19, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29350316/influence-of-personality-and-motivation-on-oral-presentation-performance
#10
Hsin-Yi Liang, Brent Kelsen
Personality and motivation have been identified as influential variables associated with foreign language learning; however, few studies have investigated their effect on oral presentations. This study addresses the importance of both personality and motivation in students' collaborative oral presentation performance. A Big Five personality trait questionnaire measuring Extraversion, Agreeableness, Conscientiousness, Neuroticism and Openness to Experience, together with the Collaborative Inquiry-based Project Questionnaire measuring Task, Project Work, Reinforcement, Social Learning and Social Pressure motivational constructs were employed to evaluate 257 university students...
January 19, 2018: Journal of Psycholinguistic Research
https://www.readbyqxmd.com/read/29350091/stent-assisted-coiling-of-cerebral-aneurysms-with-the-neuroform-atlas-stent
#11
Ferdi Cay, Ahmet Peker, Anıl Arat
Objectives The Neuroform Atlas stent (AS) is the smallest intracranial stent with an open-cell design. This study reports the first clinical experience with AS. Methods All intracranial aneurysms treated by stent-assisted coiling using a single AS in a single institution were retrospectively evaluated. Patient demographics, aneurysm characteristics, angles between the parent artery and stented branch, technical success, and clinical and angiographic follow-up were analyzed. Results Fifty-five consecutive aneurysms treated with AS-assisted coiling were included...
January 1, 2018: Interventional Neuroradiology
https://www.readbyqxmd.com/read/29350001/-analysis-of-complications-of-percutaneous-endoscopic-lumbar-discectomy
#12
Ke-Lun Huang, Hong-Lin Teng, Min-Yu Zhu, Jing Wang, Chi Li, Yu Wang
OBJECTIVE: To analyze the complications of lumbar intervertebral disc herniation treated with percutaneous endoscopic lumbar discectomy(PELD), and discuss how to avoid these complications. METHODS: The data of 132 patients with lumbar intervertebral disc herniation underwent PELD from October 2013 and June 2015 were retrospectively analyzed, including 85 males and 47 females with an average age of 42.9 years old. There were 6 cases of L₃,₄, 68 of L₄,₅ and 58 of L₅S₁...
February 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29349852/what-really-matters-to-people-with-aphasia-when-it-comes-to-group-work-a-qualitative-investigation-of-factors-impacting-participation-and-integration
#13
Lucette Lanyon, Linda Worrall, Miranda Rose
BACKGROUND: Participation in a group environment is an inherently complex undertaking for people with aphasia. It involves engaging in multi-person interactions with other people who may have a range of communication strengths and strategies at their disposal. The potential challenges of community aphasia-group participation and practice has had limited attention in the research literature. Evidence from group users have primarily been drawn from the perspective of long-term members or those participating in highly specific and time-bound groups...
January 19, 2018: International Journal of Language & Communication Disorders
https://www.readbyqxmd.com/read/29349793/the-effectiveness-and-safety-of-ledipasvir-plus-sofosbuvir-in-adolescents-with-chronic-hepatitis-c-virus-genotype-4-infection-a-real-world-experience
#14
H R El-Khayat, E M Kamal, M H El-Sayed, M El-Shabrawi, H Ayoub, A RizK, M Maher, R Y El Sheemy, Y M Fouad, D Attia
BACKGROUND: The combination of ledipasvir plus sofosbuvir was recently approved for treatment of adolescent (12-17 years) HCV genotype 1, 4, 5 & 6 patients. However, few clinical trials have been performed in genotype 1 patients. AIM: To investigate the effectiveness and safety of ledipasvir plus sofosbuvir in chronic HCV adolescent patients with genotype 4 in the real world. METHODS: This prospective multicentre (six centres) open-label study included 144 adolescent chronic HCV patients with genotype 4 (mean age 14 ± 2, 69% males)...
January 19, 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29349491/formulation-and-stabilization-of-an-arthrobacter-strain-with-good-storage-stability-and-4-chlorophenol-degradation-activity-for-bioremediation
#15
Joakim Bjerketorp, Wilfred F M Röling, Xin-Mei Feng, Armando Hernández Garcia, Hermann J Heipieper, Sebastian Håkansson
Chlorophenols are widespread and of environmental concern due to their toxic and carcinogenic properties. Development of less costly and less technically challenging remediation methods are needed; therefore, we developed a formulation based on micronized vermiculite that, when air-dried, resulted in a granular product containing the 4-chlorophenol (4-CP)-degrading Gram-positive bacterium Arthrobacter chlorophenolicus A6. This formulation and stabilization method yielded survival rates of about 60% that remained stable in storage for at least 3 months at 4 °C...
January 18, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29348700/open-air-sprays-for-capturing-and-controlling-airborne-float-coal-dust-on-longwall-faces
#16
T W Beck, C E Seaman, M R Shahan, S E Mischler
Float dust deposits in coal mine return airways pose a risk in the event of a methane ignition. Controlling airborne dust prior to deposition in the return would make current rock dusting practices more effective and reduce the risk of coal-dust-fueled explosions. The goal of this U.S. National Institute for Occupational Safety and Health study is to determine the potential of open-air water sprays to reduce concentrations of airborne float coal dust, smaller than 75 µm in diameter, in longwall face airstreams...
January 2018: Mining Engineering
https://www.readbyqxmd.com/read/29348621/dynamic-cellular-maps-of-molecular-species-application-to-drug-target-interactions
#17
Carolina García, Alejandro Losada, Miguel A Sacristán, Juan Fernando Martínez-Leal, Carlos M Galmarini, M Pilar Lillo
The design of living cell studies aimed at deciphering the mechanism of action of drugs targeting proteins with multiple functions, expressed in a wide range of concentrations and cellular locations, is a real challenge. We recently showed that the antitumor drug plitidepsin (APL) localizes sufficiently close to the elongation factor eEF1A2 so as to suggest the formation of drug-protein complexes in living cells. Here we present an extension of our previous micro-spectroscopy study, that combines Generalized Polarization (GP) images, with the phasor approach and fluorescence lifetime imaging microscopy (FLIM), using a 7-aminocoumarin drug analog (APL*) as fluorescence tracer...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29347540/compliant-contact-versus-rigid-contact-a-comparison-in-the-context-of-granular-dynamics
#18
Arman Pazouki, Michał Kwarta, Kyle Williams, William Likos, Radu Serban, Paramsothy Jayakumar, Dan Negrut
We summarize and numerically compare two approaches for modeling and simulating the dynamics of dry granular matter. The first one, the discrete-element method via penalty (DEM-P), is commonly used in the soft matter physics and geomechanics communities; it can be traced back to the work of Cundall and Strack [P. Cundall, Proc. Symp. ISRM, Nancy, France 1, 129 (1971); P. Cundall and O. Strack, Geotechnique 29, 47 (1979)GTNQA80016-850510.1680/geot.1979.29.1.47]. The second approach, the discrete-element method via complementarity (DEM-C), considers the grains perfectly rigid and enforces nonpenetration via complementarity conditions; it is commonly used in robotics and computer graphics applications and had two strong promoters in Moreau and Jean [J...
October 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347377/edge-instability-in-incompressible-planar-active-fluids
#19
David Nesbitt, Gunnar Pruessner, Chiu Fan Lee
Interfacial instability is highly relevant to many important biological processes. A key example arises in wound healing experiments, which observe that an epithelial layer with an initially straight edge does not heal uniformly. We consider the phenomenon in the context of active fluids. Improving upon the approximation used by Zimmermann, Basan, and Levine [Eur. Phys. J.: Spec. Top. 223, 1259 (2014)1951-635510.1140/epjst/e2014-02189-7], we perform a linear stability analysis on a two-dimensional incompressible hydrodynamic model of an active fluid with an open interface...
December 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347308/clogging-of-soft-particles-in-two-dimensional-hoppers
#20
Xia Hong, Meghan Kohne, Mia Morrell, Haoran Wang, Eric R Weeks
Using experiments and simulations, we study the flow of soft particles through quasi-two-dimensional hoppers. The first experiment uses oil-in-water emulsion droplets in a thin sample chamber. Due to surfactants coating the droplets, they easily slide past each other, approximating soft frictionless disks. For these droplets, clogging at the hopper exit requires a narrow hopper opening only slightly larger than the droplet diameter. The second experiment uses soft hydrogel particles in a thin sample chamber, where we vary gravity by changing the tilt angle of the chamber...
December 2017: Physical Review. E
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