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https://www.readbyqxmd.com/read/28227974/heart-rate-variability-as-a-biomarker-for-sedation-depth-estimation-in-icu-patients
#1
Sunil B Nagaraj, Sowmya M Ramaswamy, Siddharth Biswal, Emily J Boyle, David W Zhou, Lauren M Mcclain, Eric S Rosenthal, Patrick L Purdon, M Brandon Westover, Sunil B Nagaraj, Sowmya M Ramaswamy, Siddharth Biswal, Emily J Boyle, David W Zhou, Lauren M Mcclain, Eric S Rosenthal, Patrick L Purdon, M Brandon Westover, M Brandon Westover, Sunil B Nagaraj, Siddharth Biswal, Sowmya M Ramaswamy, Lauren M Mcclain, David W Zhou, Emily J Boyle, Patrick L Purdon, Eric S Rosenthal
An automated patient-specific system to classify the level of sedation in ICU patients using heart rate variability signal is presented in this paper. ECG from 70 mechanically ventilated adult patients with administered sedatives in an ICU setting were used to develop a support vector machine based system for sedation depth monitoring using several heart rate variability measures. A leave-one-subject-out cross validation was used for classifier training and performance evaluations. The proposed patient-specific system provided a sensitivity, specificity and an AUC of 64%, 84...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227964/cross-entropy-optimization-for-neuromodulation
#2
Harleen K Brar, Yunpeng Pan, Babak Mahmoudi, Evangelos A Theodorou, Harleen K Brar, Yunpeng Pan, Babak Mahmoudi, Evangelos A Theodorou, Yunpeng Pan, Harleen K Brar, Babak Mahmoudi, Evangelos A Theodorou
This study presents a reinforcement learning approach for the optimization of the proportional-integral gains of the feedback controller represented in a computational model of epilepsy. The chaotic oscillator model provides a feedback control systems view of the dynamics of an epileptic brain with an internal feedback controller representative of the natural seizure suppression mechanism within the brain circuitry. Normal and pathological brain activity is simulated in this model by adjusting the feedback gain values of the internal controller...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227961/balancing-accuracy-delay-and-battery-autonomy-for-pervasive-seizure-detection
#3
Athanasios Karapatis, Robert M Seepers, Marijn van Dongen, Wouter A Serdijn, Christos Strydis, Athanasios Karapatis, Robert M Seepers, Marijn van Dongen, Wouter A Serdijn, Christos Strydis, Athanasios Karapatis, Wouter A Serdijn, Robert M Seepers, Christos Strydis, Marijn van Dongen
A promising alternative for treating absence seizures has emerged through closed-loop neurostimulation, which utilizes a wearable or implantable device to detect and subsequently suppress epileptic seizures. Such devices should detect seizures fast and with high accuracy, while respecting the strict energy budget on which they operate. Previous work has overlooked one or more of these requirements, resulting in solutions which are not suitable for continuous closed-loop stimulation. In this paper, we perform an in-depth design space exploration of a novel seizure-detection algorithm, which uses a complex Morlet wavelet filter and a static thresholding mechanism to detect absence seizures...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227956/a-wirelessly-powered-homecage-with-animal-behavior-analysis-and-closed-loop-power-control
#4
Yaoyao Jia, Zheyuan Wang, Daniel Canales, Morgan Tinkler, Chia-Chun Hsu, Teresa E Madsen, S Abdollah Mirbozorgi, Donald Rainnie, Maysam Ghovanloo, Yaoyao Jia, Zheyuan Wang, Daniel Canales, Morgan Tinkler, Chia-Chun Hsu, Teresa E Madsen, S Abdollah Mirbozorgi, Donald Rainnie, Maysam Ghovanloo, Donald Rainnie, Chia-Chun Hsu, Teresa E Madsen, Morgan Tinkler, Daniel Canales, Zheyuan Wang, S Abdollah Mirbozorgi, Maysam Ghovanloo, Yaoyao Jia
This paper presents a new EnerCage-homecage system, EnerCage-HC2, for longitudinal electrophysiology data acquisition experiments on small freely moving animal subjects, such as rodents. EnerCage-HC2 is equipped with multi-coil wireless power transmission (WPT), closed-loop power control, bidirectional data communication via Bluetooth Low Energy (BLE), and Microsoft Kinect® based animal behavior tracking and analysis. The EnerCage-HC2 achieves a homogeneous power transfer efficiency (PTE) of 14% on average, with ~42 mW power delivered to the load (PDL) at a nominal height of 7 cm by the closed-loop power control mechanism...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227948/stayfit-a-wearable-application-for-gym-based-power-training
#5
Maram Maheedhar, Aman Gaurav, Vivek Jilla, Vijay N Tiwari, Rangavittal Narayanan, Maram Maheedhar, Aman Gaurav, Vivek Jilla, Vijay N Tiwari, Rangavittal Narayanan, Rangavittal Narayanan, Vijay N Tiwari, Vivek Jilla, Aman Gaurav, Maram Maheedhar
Comprehensive fitness training involves both cardiorespiratory and power components. Often power/muscle strength training is confused with cardiorespiratory endurance training. However, each of them target different physiological aspects of fitness. Although, wearable based fitness trackers designed towards cardiorespiratory endurance training are available in the market, a dedicated wearable based fitness application designed for power training/tracking is still not readily available to fitness enthusiasts...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227942/unified-phase-variables-of-relative-degree-two-for-human-locomotion
#6
Dario J Villarreal, Robert D Gregg, Dario J Villarreal, Robert D Gregg, Robert D Gregg, Dario J Villarreal
A starting point to achieve stable locomotion is synchronizing the leg joint kinematics during the gait cycle. Some biped robots parameterize a nonlinear controller (e.g., input-output feedback linearization) whose main objective is to track specific kinematic trajectories as a function of a single mechanical variable (i.e., a phase variable) in order to allow the robot to walk. A phase variable capable of parameterizing the entire gait cycle, the hip phase angle, has been used to control wearable robots and was recently shown to provide a robust representation of the phase of human gait...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227912/a-hybrid-discrete-continuous-model-of-in-vitro-spheroid-tumor-growth-and-drug-response
#7
Giorgos Tzedakis, Evangelos Liapis, Eleftheria Tzamali, Giannis Zacharakis, Vangelis Sakkalis, Giorgos Tzedakis, Evangelos Liapis, Eleftheria Tzamali, Giannis Zacharakis, Vangelis Sakkalis, Giannis Zacharakis, Vangelis Sakkalis, Evangelos Liapis, Giorgos Tzedakis, Eleftheria Tzamali
Anti-cancer therapy efficacy in solid tumors mainly depends on drug transportation through the vasculature system and the extracellular matrix, on diffusion gradients and clonal heterogeneity within the tumor mass, as well as on the responses of the individual tumor cells to drugs and their interactions with each other and their local microenvironment. In this work, we develop a mathematical predictive model for tumor growth and drug response based on 3D spheroids experiments that possess several in vivo features of tumors and are considered better for drug screening...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227911/an-implementation-for-the-simulation-of-cells-on-micro-post-arrays
#8
Duy T Truong, Christian Bahls, Barbara Nebe, Ursula van Rienen, Duy T Truong, Christian Bahls, Barbara Nebe, Ursula van Rienen, Duy T Truong, Christian Bahls, Ursula van Rienen, Barbara Nebe
The mechanical interaction between cells and their underlying substrates is important in understanding the processes that take place at an interface between biological tissue and the surface of implants. There have been numerous studies that examine these interactions both by experimental and numerical modeling. The bio-chemo-mechanical model for cell contractility by Deshpande et al. [1] has numerous applications and advantages. This work shows a way to implement this model in COMSOL MULTIPHYSICS® so it can be easily modified or extended...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227909/neuromorphic-circuit-modeling-directional-selectivity-in-the-visual-cortex
#9
Saeid Barzegarjalali, Alice C Parker, Saeid Barzegarjalali, Alice C Parker, Alice C Parker, Saeid Barzegarjalali
We have designed a neuromorphic circuit that models directional selectivity in the visual cortex, where selected neurons fire depending on the direction of object motion, along with the size and orientation of the object. The neuromorphic circuit is biomimetic. It consists of neurons and synapses, and models biological mechanisms. Neurons (including the Axon Hillock and the Dendritic Arbor) are designed with CMOS technology and synapses (both excitatory and inhibitory) are designed with Carbon Nanotube Transistors...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227892/investigation-of-changes-in-the-electrical-properties-of-novel-knitted-conductive-textiles-during-cyclic-loading
#10
Cristina Isaia, Donal McNally, Simon A McMaster, David T Branson, Cristina Isaia, Donal McNally, Simon A McMaster, David T Branson, Simon A McMaster, Donal McNally, Cristina Isaia, David T Branson
Combining stainless steel with polyester fibres adds an attractive conductive behaviour to the yarn. Once knitted in such a manner, fabrics develop sensing properties that make the textiles, also known as e-textiles, suitable for smart/wearable applications. Structural deformations of the fibres (e.g. stretching) will cause changes in the conductivity of the fabric. This work investigates changes in the electrical properties exhibited by four knitted conductive textiles made of 20% stainless steel and 80% polyester fibres during cyclic loading...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227886/development-of-an-open-source-cosimulation-method-of-the-knee
#11
Anne Schmitz, Davide Piovesan, Anne Schmitz, Davide Piovesan, Anne Schmitz, Davide Piovesan
Rigid body dynamics and soft tissue loads are solved simultaneously in a cosimulation framework to couple musculoskeletal dynamics and tissue mechanics. The goal of this work was to implement a validated, open-source cosimulation framework of the knee to determine how this coupling affects computed cartilage loads. The kinematic knee joint of a generic whole body model in the open-source software OpenSim was replaced by a previously developed discrete element knee model that consisted of a six degree of freedom (dof) tibiofemoral joint and one dof patellofemoral joint...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227883/development-and-validation-of-thums-version-5-with-1d-muscle-models-for-active-and-passive-automotive-safety-research
#12
Hideyuki Kimpara, Yuko Nakahira, Masami Iwamoto, Hideyuki Kimpara, Yuko Nakahira, Masami Iwamoto, Hideyuki Kimpara, Masami Iwamoto, Yuko Nakahira
Accurately predicting the occupant kinematics is critical to better understand the injury mechanisms during an automotive crash event. The objectives of this study were to develop and validate a finite element (FE) model of the human body integrated with an active muscle model called Total HUman Model for Safety (THUMS) version 5, which has the body size of the 50th percentile American adult male (AM50). This model is characterized by being able to generate a force owing to muscle tone and to predict the occupant response during an automotive crash event...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227873/a-comprehensive-reputation-mechanism-for-ubiquitous-healthcare-environment-exploiting-cloud-model
#13
Georgia Athanasiou, Dimitrios Lymberopoulos, Georgia Athanasiou, Dimitrios Lymberopoulos, Dimitrios Lymberopoulos, Georgia Athanasiou
Absence of trust foundations may outweigh benefits of ubiquitous and personalized mental healthcare supervision provided within a Ubiquitous Healthcare environment (UH). Trust is composed by patient's Personal Interaction Experience (PIE) and social entourage accumulated PIE, i.e. Reputation (R). In this paper, a cloud-based Reputation mechanism is proposed. Since PIE is the elementary trust information source, also an Updating mechanism of PIE, is introduced, in this paper. Cloud materialization of combined mechanisms provides adaptability to UH Providers' dynamic behavior, facilitates detection of milking behaviors and complex malicious attacks while meets the challenge of limited accuracy in case of data sparseness...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227868/middle-and-inner-ear-modelling-from-microct-images-to-3d-reconstruction-and-coupling-of-models
#14
N S Tachos, A I Sakellarios, G Rigas, V Isailovic, G Ni, F Bohnke, N Filipovic, T Bibas, D I Fotiadis, N S Tachos, A I Sakellarios, G Rigas, V Isailovic, G Ni, F Bohnke, N Filipovic, T Bibas, D I Fotiadis, A I Sakellarios, V Isailovic, D I Fotiadis, A Bibas, F Bohnke, G Ni, N Filipovic, G Rigas, N S Tachos
We present finite element (FE) modeling approaches of ear mechanics including 3-dimensional (3D) reconstruction of the human middle and inner ear. Specifically, we demonstrate a semi-automatic methodology for the 3D reconstruction of the inner ear structures, a FE harmonic response model of the middle ear to predict the stapes footplate frequency response, a 2D FE slice model of the cochlea for the coupled response at the micromechanical level for either acoustic or electrical excitation and a coupled FE middle ear model with a simplified cochlea box model to simulate the basilar membrane velocity in response to acoustic excitation...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227851/design-and-validation-of-a-high-order-weighted-frequency-fourier-linear-combiner-based-kalman-filter-for-parkinsonian-tremor-estimation
#15
Y Zhou, M E Jenkins, M D Naish, A L Trejos, Y Zhou, M E Jenkins, M D Naish, A L Trejos, M E Jenkins, M D Naish, Y Zhou, A L Trejos
The design of a tremor estimator is an important part of designing mechanical tremor suppression orthoses. A number of tremor estimators have been developed and applied with the assumption that tremor is a mono-frequency signal. However, recent experimental studies have shown that Parkinsonian tremor consists of multiple frequencies, and that the second and third harmonics make a large contribution to the tremor. Thus, the current estimators may have limited performance on estimation of the tremor harmonics...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227848/motion-noise-cancellation-in-seismocardiogram-of-ambulant-subjects-with-dual-sensors
#16
Chenxi Yang, Negar Tavassolian, Chenxi Yang, Negar Tavassolian, Negar Tavassolian, Chenxi Yang
This paper presents a dual-sensor method of extracting seismocardiographic (SCG) data from moving adult subjects using chest-worn wireless MEMS accelerometers. A digital signal processing (DSP) system including a normalized least means square (NLMS) adaptive filter is designed and tested in MATLAB. Data results from 10 subjects indicate a detection rate of 98.72% which outperforms our previously-proposed single-sensor scheme. Various sensor positons and possible failure mechanisms are also investigated to further evaluate the system performance...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227837/progressive-abduction-loading-therapy-targeting-flexion-synergy-to-regain-reaching-function-in-chronic-stroke-preliminary-results-from-an-rct
#17
Michael D Ellis, Carolina Carmona, Justin Drogos, Stuart Traxel, Julius P A Dewald, Michael D Ellis, Carolina Carmona, Justin Drogos, Stuart Traxel, Julius P A Dewald, Stuart Traxel, Michael D Ellis, Carolina Carmona, Julius P A Dewald, Justin Drogos
Reaching function is impaired following stroke due to abnormal coupling of shoulder abduction and elbow flexion. This phenomenon is commonly referred to as flexion synergy, loss of independent joint control, or impaired joint individuation. We have been successful in treating individuals with chronic stroke with moderate to severe motor impairments through the employment of targeted rehabilitation robotics and identified progressive abduction loading as a key element to the rehabilitation of reaching. Here we expand upon the investigation of progressive abduction loading therapy by testing two variants of the exercise in a larger sample and including a 3-month follow-up...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227832/sinusoidal-stimulation-trains-suppress-epileptiform-spikes-induced-by-4-ap-in-the-rat-hippocampal-ca1-region-in-vivo
#18
Zheshan Guo, Zhouyan Feng, Ying Yu, Wenjie Zhou, Zhaoxiang Wang, Xuefeng Wei, Zheshan Guo, Zhouyan Feng, Ying Yu, Wenjie Zhou, Zhaoxiang Wang, Xuefeng Wei, Ying Yu, Zhouyan Feng, Xuefeng Wei, Zhaoxiang Wang, Zheshan Guo, Wenjie Zhou
Deep brain stimulation (DBS) shows promises in the treatment of refractory epilepsy. Due to the complex causes of epilepsy, the mechanisms of DBS are still unclear. Depolarization block caused by the persistent excitation of neurons may be one of the possible mechanisms. To test the hypothesis, 4-aminopyridine (4-AP) was injected in rat hippocampal CA1 region in-vivo to induce epileptiform activity. Sinusoidal stimulation trains were applied to the afferent pathway (Schaffer collaterals) of CA1 region to suppress the epileptiform spikes...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227831/detection-of-single-unit-spikes-during-orthodromic-high-frequency-stimulation-in-rat-hippocampus
#19
Zhaoxiang Wang, Zhouyan Feng, Ying Yu, Yufang Zhu, Zheshan Guo, Zhaoxiang Wang, Zhouyan Feng, Ying Yu, Yufang Zhu, Zheshan Guo, Yufang Zhu, Ying Yu, Zhouyan Feng, Zhaoxiang Wang, Zheshan Guo
Deep brain stimulation (DBS) has been used as a treatment of brain diseases such as Parkinson's disease and is a promising therapy for epilepsy. But the mechanisms of high frequency stimulation (HFS) used by DBS are still uncertain. In order to investigate the changes of action penitential firings of individual neurons (single unit activity, SUA) during the period of HFS, a new algorithm based on window detection was designed to detect spikes in broadband-frequency recording signals. The results show that orthodromic-HFS (O-HFS) could excite the neurons in CA1 regions, and the firing rate of interneurons and pyramidal neurons increased significantly...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227817/polyimide-based-magnetic-microactuators-for-biofouling-removal
#20
Qi Yang, Tran Nguyen, Chunan Liu, Jacob Miller, Jeffrey F Rhoads, Jacqueline Linnes, Hyowon Lee, Qi Yang, Tran Nguyen, Chunan Liu, Jacob Miller, Jeffrey F Rhoads, Jacqueline Linnes, Hyowon Lee, Jacqueline Linnes, Chunan Liu, Tran Nguyen, Jacob Miller, Jeffrey F Rhoads, Hyowon Lee, Qi Yang
Here we report on the development of novel polyimide-based flexible magnetic actuators for improving hydrocephalus shunts. The static and dynamic mechanical responses of the thin-film magnetic microdevices were quantitatively measured. The bacteria-removing capabilities of the microfabricated devices were also evaluated. Although additional evaluations are necessary, the preliminary results show promising potential for combatting bacteria-induced biofouling. Lastly, the thin-film microdevices are integrated into a single-pore silicone catheter to demonstrate a proof-of-concept, MEMS-enabled self-clearing, smart catheter...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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