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https://www.readbyqxmd.com/read/28813096/cytotoxicity-and-bacterial-membrane-destabilization-induced-by-annona-squamosa-l-extracts
#1
Nícolas C C Pinto, Jucélia B Silva, Laura M Menegati, Maria Clara M R Guedes, Lucas B Marques, Thiago P DA Silva, Rossana C N DE Melo, Elaine M DE Souza-Fagundes, Marcos J Salvador, Elita Scio, Rodrigo L Fabri
This study aimed to further investigate the cytotoxicity against tumor cell lines and several bacterial strains of Annona squamosa and its mode of action. Methanol extracts of A. squamosa leaves (ASL) and seeds (ASS) were used. ASL showed significant antibacterial activity against S. aureus, K. pneumoniae and E. faecalis with MIC values of 78, 78 and 39 µg/mL respectively. Moreover, ASL exhibited significant biofilm disruption, rapid time dependent kinetics of bacterial killing, increased membrane permeability and significantly reduced the cell numbers and viability...
August 14, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28813071/content-validation-clarity-relevance-reliability-and-internal-consistency-of-enunciative-signs-of-language-acquisition
#2
Anelise Henrich Crestani, Anaelena Bragança de Moraes, Ana Paula Ramos de Souza
Purpose: To analyze the results of the validation of building enunciative signs of language acquisition for children aged 3 to 12 months. Methods: The signs were built based on mechanisms of language acquisition in an enunciative perspective and on clinical experience with language disorders. The signs were submitted to judgment of clarity and relevance by a sample of six experts, doctors in linguistic in with knowledge of psycholinguistics and language clinic. In the validation of reliability, two judges/evaluators helped to implement the instruments in videos of 20% of the total sample of mother-infant dyads using the inter-evaluator method...
August 10, 2017: CoDAS
https://www.readbyqxmd.com/read/28813066/multivalent-mesoporous-silica-nanoparticles-photo-delivering-nitric-oxide-with-carbon-dots-as-fluorescence-reporters
#3
Damien Afonso, Sabrina Valetti, Aurore Fraix, Claudia Bascetta, Salvatore Petralia, Sabrina Conoci, Adam Feiler, Salvatore Sortino
Amino-terminated mesoporous silica nanoparticles embedding carbon dots (MSCD) formed by calcination were functionalized with a nitric oxide (NO) photodonor (1) to give a robust MSCD-1 conjugate. The intense fluorescence of MSCDs was strongly quenched in MSCD-1 by effective energy transfer. Visible light excitation of MSCD-1 liberates NO, suppresses the energy transfer mechanism and leads to concomitant fluorescence restoration of the MSCD scaffold, which acts as an optical reporter for the released NO. The MSCD-1 hybrid is also able to encapsulate the highly hydrophobic photosensitizer temoporfin, preserving the fluorescence reporting function...
August 16, 2017: Nanoscale
https://www.readbyqxmd.com/read/28813052/mixed-ligand-iridium-iii-complexes-as-photodynamic-anticancer-agents
#4
Yue Zheng, Liang He, Dong-Yang Zhang, Cai-Ping Tan, Liang-Nian Ji, Zong-Wan Mao
Many phosphorescent iridium complexes are potent candidates as photodynamic therapeutic agents. In this work, a series of mixed-ligand phosphorescent iridium complexes (Ir1: [Ir(L1)(bpy)Cl](PF6)2; Ir2: [Ir(L1)(ppy)Cl](PF6); Ir3: [Ir(L2)(bpy)Cl](PF6)2; Ir4: [Ir(L2)(ppy)Cl](PF6). L1 = 2,6-bis(2-benzimidazolyl)pyridine; bpy = 2,2'-bipyridine; L2 = 2,6-bis(1-methyl-benzimidazol-2-yl)pyridine; ppy = 2-phenylpyridine) have been synthesized and characterized. These complexes display high luminescence quantum yields and long phosphorescence lifetimes...
August 16, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28813042/the-carotenoid-pathway-what-is-important-for-excitation-quenching-in-plant-antenna-complexes
#5
Kieran F Fox, Vytautas Balevičius, Jevgenij Chmeliov, Leonas Valkunas, Alexander V Ruban, Christopher D P Duffy
Plant light-harvesting is regulated by the Non-Photochemical Quenching (NPQ) mechanism involving the reversible formation of excitation quenching sites in the Photosystem II (PSII) antenna in response to high light. While the major antenna complex, LHCII, is known to be a site of NPQ, the precise mechanism of excitation quenching is not clearly understood. A preliminary model of the quenched crystal structure of LHCII implied that quenching arises from slow energy capture by Car pigments. It predicted a thoroughly quenched system but offered little insight into the defining aspects of this quenching...
August 16, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28813027/sulfonamide-linked-ciprofloxacin-sulfadiazine-and-amantadine-derivatives-as-a-novel-class-of-inhibitors-of-jack-bean-urease-synthesis-kinetic-mechanism-and-molecular-docking
#6
Pervaiz Ali Channar, Aamer Saeed, Fernando Albericio, Fayaz Ali Larik, Qamar Abbas, Mubashir Hassan, Hussain Raza, Sung-Yum Seo
Sulfonamide derivatives serve as an important building blocks in the drug design discovery and development (4D) process. Ciprofloxacin-, sulfadiazine- and amantadine-based sulfonamides were synthesized as potent inhibitors of jack bean urease and free radical scavengers. Molecular diversity was explored and electronic factors were also examined. All 24 synthesized compounds exhibited excellent potential against urease enzyme. Compound 3e (IC50 = 0.081 ± 0.003 µM), 6a (IC50 = 0.0022 ± 0.0002 µM), 9e (IC50 = 0...
August 16, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28813025/association-between-promoter-methylation-of-gene-ercc3-and-benzene-hematotoxicity
#7
Min Zheng, Feiliang Lin, Fenxia Hou, Guilan Li, Caiying Zhu, Peiyu Xu, Caihong Xing, Qianfei Wang
Benzene is a primary industrial chemical and a ubiquitous environmental pollutant. ERCC3 is a key player in nucleotide excision repair. Recent studies suggested that site-specific methylation is a possible mechanism of the transcriptional dysregulation by blocking transcription factors binding. We previously found that the average promoter methylation level of ERCC3 was increased in benzene-exposed workers. In order to test whether specific CpG sites of ERCC3 play an important role in benzene-induced epigenetic changes and whether the specific methylation patterns are associated with benzene hematotoxicity, we analyzed the promoter methylation levels of individual CpG sites, transcription factor binding motif and the correlation between aberrant CpG methylation and hematotoxicity in 76 benzene-exposed workers and 24 unexposed controls in China...
August 16, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28813024/advances-in-understanding-of-penile-carcinogenesis-the-search-for-actionable-targets
#8
REVIEW
Juan Chipollini, Sharon Chaing, Mounsif Azizi, Laura C Kidd, Patricia Kim, Philippe E Spiess
Penile cancer (PeCa) is a rare malignancy with potentially devastating effects. Squamous cell carcinoma is the most common variant with distinct precancerous lesions before development into invasive disease. Involvement of the inguinal lymph nodes is the most important prognostic factor in PeCa, and once disease is present outside the groin, prognosis is poor. Metastatic PeCa is challenging to treat and often requires multidisciplinary approaches in management. Due to its rarity, molecular understanding of the disease continues to be limited with most studies based on small, single center series...
August 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28813019/grafting-modification-of-the-reactive-core-shell-particles-to-enhance-the-toughening-ability-of-polylactide
#9
Zhaokun Li, Shixin Song, Xuanchen Zhao, Xue Lv, Shulin Sun
In order to overcome the brittleness of polylactide (PLA), reactive core-shell particles (RCS) with polybutadiene as core and methyl methacrylate-co-styrene-co-glycidyl methacrylate as shell were prepared to toughen PLA. Tert-dodecyl mercaptan (TDDM) was used as chain transfer agent to modify the grafting properties (such as grafting degree, shell thickness, internal and external grafting) of the core-shell particles. The introduction of TDDM decreased the grafting degree, shell thickness and the Tg of the core phase...
August 16, 2017: Materials
https://www.readbyqxmd.com/read/28812994/organ-organ-crosstalk-and-alcoholic-liver-disease
#10
REVIEW
Lauren G Poole, Christine E Dolin, Gavin E Arteel
Alcohol consumption is a common custom worldwide, and the toxic effects of alcohol on several target organs are well-understood. Given the poor prognosis of treating clinically-relevant alcoholic liver disease (ALD) (i.e., alcoholic hepatitis (AH) and cirrhosis), additional research is required to develop more effective therapies. While the stages of ALD have been well-characterized, targeted therapies to prevent or reverse this process in humans are still needed. Better understanding of risk factors and mechanisms underlying disease progression can lead to the development of rational therapies to prevent or reverse ALD in the clinic...
August 16, 2017: Biomolecules
https://www.readbyqxmd.com/read/28812993/enhanced-corrosion-resistance-of-carbon-steel-in-hydrochloric-acid-solution-by-eriobotrya-japonica-thunb-leaf-extract-electrochemical-study
#11
Wenjing Yang, Qihui Wang, Ke Xu, Yanjun Yin, Hebin Bao, Xueming Li, Lidan Niu, Shiqi Chen
The biodegradable inhibitors, which could effectively reduce the rate of corrosion of carbon steel, were investigated by potentiodynamic polarization and electrochemical impedance spectroscopy (EIS). The mixed-type inhibitors extracted from Eriobotrya japonica Thunb. leaf exhibited excellent inhibition performance, and the inhibition efficiency for carbon steel reached 90.0% at 298 K in hydrochloric acid. Moreover, the adsorption mechanism of the inhibitors on a carbon steel surface is described by the Langmuir adsorption isotherm...
August 16, 2017: Materials
https://www.readbyqxmd.com/read/28812955/igg-cooperativity-is-there-allostery-implications-for-antibody-functions-and-therapeutic-antibody-development
#12
Danlin Yang, Rachel Kroe-Barrett, Sanjaya Singh, Christopher J Roberts, Thomas M Laue
A central dogma in immunology is that an antibody's in vivo functionality is mediated by two independent events: antigen binding by the variable (V) region, followed by effector activation by the constant (C) region. However, this view has recently been challenged by reports suggesting allostery exists between the two regions, triggered by conformational changes or configurational differences. The possibility of allosteric signals propagating through the IgG domains complicates our understanding of the antibody structure-function relationship, and challenges the current subclass selection process in therapeutic antibody design...
August 16, 2017: MAbs
https://www.readbyqxmd.com/read/28812944/binding-forces-between-a-novel-schiff-base-palladium-ii-complex-and-two-carrier-proteins-human-serum-albumi-and%C3%AE-lactoglobulin
#13
Somaye Shahraki, Ali Heydari
Ligand binding studies on carrier proteins are crucial in determining the pharmacological properties of drug candidates. Here, a new palladium(II) complex was synthesized and characterized. The in vitro binding studies of this complexwith two carrier proteins, human serum albumin (HSA) and β-lactoglobulin (βLG) was investigated by employing biophysical techniques as well as computational modeling. The experimental results showed thatthe Pd(II) complex interacted with two carrier proteins with moderate binding affinity (Kb ~̴ 0...
August 16, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28812939/removing-dysfunctional-mitochondria-from-axons-independent-of-mitophagy-under-pathophysiological-conditions
#14
Mei-Yao Lin, Xiu-Tang Cheng, Yuxiang Xie, Qian Cai, Zu-Hang Sheng
Chronic mitochondrial dysfunction has been implicated in major neurodegenerative diseases. Long-term cumulative pathological stress leads to axonal accumulation of damaged mitochondria. Therefore, the early removal of defective mitochondria from axons constitutes a critical step of mitochondrial quality control. We recently investigated the axonal mitochondrial response to mild stress in wild-type neurons and chronic mitochondrial defects in amyotrophic lateral sclerosis (ALS)- and Alzheimer disease (AD)-linked neurons...
August 16, 2017: Autophagy
https://www.readbyqxmd.com/read/28812900/single-reactant-replacement-approach-of-passerini-reaction-one-pot-synthesis-of-%C3%AE-acyloxyamides-and-phthalides
#15
Yangyong Shen, Bo Huang, Linwei Zeng, Sunliang Cui
The Passerini reaction is a classical and well-known multicomponent reaction for accessing α-acyloxy amides. A single reactant replacement (SRR) approach of Passerini reaction is described, which involves aldehydes, carboxylic acids, and ynamides to constitute a one-pot synthesis of β-acyloxy amides in a convergent manner. When this method was subject to intramolecular reaction, the process would produce phthalide products. The scalability was demonstrated, and a crossover reaction was conducted to elucidate a plausible mechanism...
August 16, 2017: Organic Letters
https://www.readbyqxmd.com/read/28812890/jaqpot-quattro-a-novel-computational-web-platform-for-modelling-and-analysis-in-nanoinformatics
#16
Charalampos Chomenidis, Georgios Drakakis, Georgia Tsiliki, Evangelia Anagnostopoulou, Angelos Valsamis, Philip Doganis, Pantelis Sopasakis, Haralambos Sarimveis
Engineered nanomaterials (ENMs) are increasingly infiltrating our lives due to their applications across multiple fields. However, ENM formulations may result in the modulation of pathways and mechanisms of toxic action that endanger human health and the environment. Alternative testing methods such as in silico approaches are becoming increasingly popular for assessing the safety of ENMs as they are cost- and time- effective. Additionally, computational approaches support the industrial safer-by-design challenge and the REACH legislation objective of reducing animal testing...
August 16, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28812886/room-temperature-ring-opening-of-quinoline-isoquinoline-and-pyridine-with-low-valent-titanium
#17
Seung-Yeol Baek, Takashi Kurogi, Dahye Kang, Masahiro Kamitani, Seongyeon Kwon, Douglas Solowey, Chun-Hsing Chen, Maren Pink, Patrick J Carroll, Daniel J Mindiola, Mu-Hyun Baik
The complex (PNP)Ti=CHtBu(CH2tBu) (PNP = N[2-PiPr2-4-methylphenyl]2-) dehydrogenates cyclohexane to cyclohexene by forming a transient low-valent titanium-alkyl species, [(PNP)Ti(CH2tBu)], which reacts with two equivalents of quinoline (Q) at room temperature to form H3CtBu and a Ti(IV) species where the less hindered C2=N1 bond of Q is ruptured and coupled to another equivalent of Q. The product isolated from this reaction is an imide with a tethered cycloamide group, (PNP)Ti=N[C18H13N] (1). Under photolytic conditions, intramolecular C-H bond activation across the imide-moiety in 1 occurs to form 2, and thermolysis reverses this process...
August 16, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28812878/nanomechanical-imaging-of-the-diffusion-of-fullerene-into-conjugated-polymer
#18
Dong Wang, Ken Nakajima, Feng Liu, Shaowei Shi, Thomas P Russell
The large Young's modulus difference between chemically modified fullerene (PCBM) and a conjugated polymer was used to nanomechanically map the diffusion of PCBM into PTB7, a high efficiency low band gap conjugated polymer. The sharp tip in nanomechanical atomic force microscopy (AFM) ensures a high-resolution nanomechanical characterization of the diffusion front, with the intrinsic benefits of revealing the mechanical properties of the mixtures. Localized structure changes induced by diffusion were investigated by grazing incidence x-ray diffraction methods...
August 16, 2017: ACS Nano
https://www.readbyqxmd.com/read/28812874/three-dimensional-highly-stretchable-conductors-from-elastic-fiber-mat-with-conductive-polymer-coating
#19
Shasha Duan, Zhihui Wang, Ling Zhang, Jin Liu, Chunzhong Li
The manufacture of stretchable conductors with well-reserved electrical performance under large-degree deformations via scalable processes remains of great importance. In this work, a highly stretchable 3D conductive framework consisted of polyurethane fiber mat (PUF) and poly(3,4-ethylenedioxythiophene) (PEDOT) is reported through facile approaches, electrospinning and in situ interfacial polymerization, which was then backfilled with poly(dimethylsiloxane) to obtain 3D conductors. The excellent stretchability of the 3D conductive network imparted the as-prepared electrode superior mechanical durability...
August 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28812872/effect-of-mineral-dissolution-precipitation-and-co2-exsolution-on-co2-transport-in-geological-carbon-storage
#20
Ruina Xu, Rong Li, Jin Ma, Di He, Peixue Jiang
Geological carbon sequestration (GCS) in deep saline aquifers is an effective means for storing carbon dioxide to address global climate change. As the time after injection increases, the safety of storage increases as the CO2 transforms from a separate phase to CO2(aq) and HCO3(-) by dissolution and then to carbonates by mineral dissolution. However, subsequent depressurization could lead to dissolved CO2(aq) escaping from the formation water and creating a new separate phase which may reduce the GCS system safety...
August 16, 2017: Accounts of Chemical Research
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