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https://www.readbyqxmd.com/read/29793113/assessment-of-the-risk-of-antiangiogenic-agents-before-and-after-surgery
#1
REVIEW
Christina E Bailey, Alexander A Parikh
Angiogenesis plays a critical role in the growth, progression, and metastasis of numerous solid tumor types, and thus, antiangiogenic agents have been studied for many years as potential therapeutic agents. Many different antiangiogenic agents, including monoclonal antibodies and multi-targeted tyrosine kinase inhibitors (TKIs), have been approved for various oncology indications, and promising clinical activity has been demonstrated. However, some of these agents have also been associated with serious safety concerns...
May 8, 2018: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29792853/preoperative-obstructive-sleep-apnea-screening-in-gynecologic-oncology-patients
#2
Ross F Harrison, Erin E Medlin, Chase B Petersen, Stephen L Rose, Ellen M Hartenbach, David M Kushner, Ryan J Spencer, Laurel W Rice, Ahmed N Al-Niaimi
BACKGROUND: Women with a gynecologic cancer tend to be older, obese, and postmenopausal, characteristics that are associated with an increased risk for obstructive sleep apnea. However, there is limited investigation regarding the condition's prevalence in this population or its impact on postoperative outcomes. In other surgical populations, patients with obstructive sleep apnea have been observed to be at increased risk for adverse postoperative events. OBJECTIVES: To estimate the prevalence of obstructive sleep apnea among gynecologic oncology patients undergoing elective surgery and to investigate for a relationship between obstructive sleep apnea and postoperative outcomes...
May 21, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29790976/cancer-dissemination-hydrocephalus-and-survival-after-cerebral-ventricular-entry-during-high-grade-glioma-surgery-a-meta-analysis
#3
Akshitkumar M Mistry, Patrick D Kelly, Reid C Thompson, Lola B Chambless
BACKGROUND: The consequences of ventricular entry during resection of high-grade gliomas (HGG) are uncertain and often not detectable clinically. OBJECTIVE: To reveal odds of tumor dissemination, hydrocephalus, and mortality in adult patients who had ventricular entry during surgical resection of HGG. METHODS: Titles and abstracts of published journals in the NCBI/NLM PubMed and OVID EMBASE databases were searched without language restriction and systematically screened...
May 22, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29779391/-is-preoperative-systemic-chemotherapy-recommended-for-resectable-colorectal-liver-metastases-oncosurgical-aspects
#4
Kristóf Dede, Zsuzsa Póti, Attila Bursics
Surgical resection is still the only curative treatment for colorectal liver metastases, but this is one part of a complex therapy. Nowadays a patient with colorectal liver metastasis is not treated only by a surgeon or by an oncologist or even only by an invasive radiologist. Collective decisions, complement treatments give the only chance to treat these patients for longer time. Patients with colorectal liver metastases could be regarded as patients with chronic disease. Specially interesting are the various treatment options of resectable colorectal liver metastases...
May 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29764185/management-of-metastatic-spinal-cord-compression-among-veterans-health-administration-radiation-oncologists
#5
Ruchika Gutt, Sheeta Malhotra, Shruti Jolly, Drew Moghanaki, Alice V Cheuk, Helen Fosmire, Maria Kelly, Lori Hoffman-Hogg, Stephen Lutz, Mitchell Anscher, George Dawson
BACKGROUND: Optimal management of metastatic spinal cord compression (MSCC) improves functional outcomes in patients with metastatic disease. This survey study evaluated management of MSCC by Veterans Health Administration (VHA) radiation oncologists (ROs), to determine whether management of MSCC correlates with American College of Radiology (ACR) guidelines, and to compare times to initiation of treatment between surgery and radiotherapy (RT). METHODS: Surveys emailed to 79 VHA ROs included questions on steroid use, surgical care, palliative care, fractionation of irradiation, re-irradiation, and management of common MSCC case scenarios...
April 2018: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/29761863/surgical-treatment-of-esophageal-cancer-in-the-era-of-multimodality-management
#6
REVIEW
Alicia S Borggreve, B Feike Kingma, Serg A Domrachev, Mikhail A Koshkin, Jelle P Ruurda, Richard van Hillegersberg, Flavio R Takeda, Lucas Goense
Over the last decades, the treatment of resectable esophageal cancer has evolved into a multidisciplinary process in which all players are essential for treatment to be successful. Medical oncologists and radiation oncologists have been increasingly involved since the implementation of neoadjuvant therapy, which has been shown to improve survival. Although esophagectomy is still considered the cornerstone of curative treatment for locally advanced esophageal cancer, it remains associated with considerable postoperative morbidity, despite promising results of minimally invasive techniques...
May 15, 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29752148/malignant-primary-diffuse-leptomeningeal-gliomatosis-with-histone-h3-3-k27m-mutation
#7
C Champeaux, A Drier, B Devaux, A Tauziède-Espariat
INTRODUCTION: Malignant primary diffuse leptomeningeal gliomatosis (MPDLG) are rare central nervous system neoplasms associated with a poor outcome. CASE REPORT: We report the case of a 40-year-old woman who presented with unusual worsening of bilateral sciatica, headaches, diplopia and a left proptosis. MRI of the head and spine showed multiple leptomeningeal lesions with no intra parenchymal involvement. The search for a primary tumor was negative. An open surgical biopsy of the prominent intradural lumbar tumor was performed within a week...
May 8, 2018: Neuro-Chirurgie
https://www.readbyqxmd.com/read/29749569/postoperative-hypofractionated-stereotactic-brain-radiation-hsrt-for-resected-brain-metastases-improved-local-control-with-higher-bed-10
#8
Aryavarta M S Kumar, Jonathan Miller, Seth A Hoffer, David B Mansur, Michael Coffey, Simon S Lo, Andrew E Sloan, Mitchell Machtay
INTRODUCTION: HSRT directed to large surgical beds in patients with resected brain metastases improves local control while sparing patients the toxicity associated with whole brain radiation. We review our institutional series to determine factors predictive of local failure. METHODS: In a total of 39 consecutive patients with brain metastases treated from August 2011 to August 2016, 43 surgical beds were treated with HSRT in three or five fractions. All treatments were completed on a robotic radiosurgery platform using the 6D Skull tracking system...
May 10, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29737473/uptake-of-brca-1-2-and-oncotype-dx-testing-by-medical-and-surgical-oncologists
#9
Yonina R Murciano-Goroff, Anne Marie McCarthy, Mirar N Bristol, Peter Groeneveld, Susan M Domchek, U Nkiru Motanya, Katrina Armstrong
PURPOSE: The diffusion of genomic testing is critical to the success of precision medicine, but there is limited information on oncologists' uptake of genetic technology. We aimed to assess the frequency with which medical oncologists and surgeons order BRCA 1/2 and Oncotype DX testing for breast cancer patients. METHODS: We surveyed 732 oncologists and surgeons treating breast cancer patients. Physicians were from Florida, New York, New Jersey, and Pennsylvania, and were listed in the 2010 AMA Masterfile or identified by patients...
May 8, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29727349/the-feasibility-of-laparoscopic-surgery-in-gynecologic-oncology-for-obese-and-morbidly-obese-patients
#10
Jessie Peng, Sarah Sinasac, Katherine J Pulman, Liying Zhang, Joan Murphy, Tomer Feigenberg
BACKGROUND: Surgical interventions are the mainstay of treatment for many gynecological cancers. Although minimally invasive surgery offers many potential advantages, performing laparoscopic pelvic surgery in obese patients remains challenging. To overcome this, many centers have shifted their practice to robotic surgery; however, the high costs associated with robotic surgery are concerning and limit its use. OBJECTIVE: This study aimed to examine the feasibility of performing laparoscopic gynecologic oncology procedures in obese and morbidly obese patients...
June 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29719336/study-of-proliferating-cell-nuclear-antigen-expression-and-angiogenesis-in-urothelial-neoplasms-correlation-with-tumor-grade-and-stage
#11
Poojan Agarwal, Achin Kumar Sen, Minakshi Bhardwaj, Veronique Dinand, Arvind Ahuja, Rajeev Sood
Background: Urinary bladder carcinoma ranks ninth in worldwide cancer incidence. About 74,000 new cases were diagnosed in 2015 alone and 16,000 persons died of the disease. Since histopathology is considered gold standard for diagnosis, it is prudent to look for potential tumor proliferation and predictive markers in such a prevalent malignancy so as to alert surgical and medical oncologists for timely intervention and provide better patient-tailored therapy. Aims: This study is to analyze the role of potential biomarkers-proliferating cell nuclear antigen (PCNA) and angiogenesis using CD31 in urothelial neoplasms in relation to tumor grade and stage...
April 2018: Urology Annals
https://www.readbyqxmd.com/read/29719323/saudi-oncology-society-and-saudi-urology-association-combined-clinical-management-guidelines-for-prostate-cancer-2017
#12
REVIEW
Ali Aljubran, Ashraf Abusamra, Sultan Alkhateeb, Mohammed Alotaibi, Danny Rabah, Shouki Bazarbashi, Hussain Alkushi, Mubarak Al-Mansour, Hulayel Alharbi, Amin Eltijani, Abdullah Alghamdi, Abdullah Alsharm, Imran Ahmad, Esam Murshid
This is an update to the previously published Saudi guidelines for the evaluation and medical and surgical management of patients diagnosed with prostate cancer. Prostate cancer is categorized according to the stage of the disease using the tumor node metastasis staging system 7th edition. The guidelines are presented with supporting evidence levels based on a comprehensive literature review, several internationally recognized guidelines, and the collective expertise of the guidelines committee members (authors) who were selected by the Saudi Oncology Society and Saudi Urological Association...
April 2018: Urology Annals
https://www.readbyqxmd.com/read/29719322/saudi-oncology-society-and-saudi-urology-association-combined-clinical-management-guidelines-for-urothelial-cell-carcinoma-of-the-urinary-bladder-2017
#13
REVIEW
Hulayel Alharbi, Sultan Alkhateeb, Esam Murshid, Mohammed Alotaibi, Ashraf Abusamra, Danny Rabah, Mubarak Almansour, Abdullah Alghamdi, Ali Aljubran, Amin Eltigani, Hussein Alkushi, Imran Ahmed, Abdullah Alsharm, Shouki Bazarbashi
This is an update to the previously published Saudi guidelines for the evaluation and medical/surgical management of patients diagnosed with urothelial cell carcinoma of the urinary bladder. It is categorized according to the stage of the disease using the tumor node metastasis staging system, 7th edition. The guidelines are presented with their accompanying supporting evidence level, which is based on comprehensive literature review, several internationally recognized guidelines, and the collective expertise of the guidelines committee members (authors) who were selected by the Saudi Oncology Society and Saudi Urological Association...
April 2018: Urology Annals
https://www.readbyqxmd.com/read/29718792/a-younger-man-with-localized-prostate-cancer-asks-which-type-of-radiation-is-right-for-me
#14
Justin E Bekelman
The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors' suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology, to patients seen in their own clinical practice...
May 2, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29709369/palliative-care-training-and-decision-making-for-patients-with-advanced-cancer-a-comparison-of-surgeons-and-medical-physicians
#15
Sarah B Bateni, Robert J Canter, Frederick J Meyers, Joseph M Galante, Richard J Bold
BACKGROUND: Surgical decision-making in patients with advanced cancer requires careful thought and deliberation to balance the high risks with the potential palliative benefits. We sought to compare surgical decision-making and palliative care training among surgeons and medical physicians who commonly treat advanced cancer patients. We hypothesized that surgeons will report less palliative care training compared with medical physicians, and deficits in palliative care training will be associated with more aggressive treatment recommendations in clinical scenarios of advanced cancer patients with symptomatic surgical conditions...
April 27, 2018: Surgery
https://www.readbyqxmd.com/read/29705675/ovarian-metastases-from-right-colon-cancer-treated-with-systemic-cancer-chemotherapy-a-case-report
#16
Paul H Sugarbaker, John Liang
BACKGROUND: The progression of cancer from its primary site has been the focus of study of surgeons and oncologists for many decades. Why the primary disease goes on to take the life of some patients while others live out their normal lives after a surgical procedure is only partially understood. METHODS: In a patient with caecal cancer metastatic to the right ovary the clinical, radiologic, surgical and histopathologic findings are presented. Efforts were made to confirm that the disease process was from a single primary site (colon cancer) and not two primary sites (colon cancer and ovarian cancer)...
April 21, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29689237/dutch-lung-surgery-audit-a-national-audit-comprising-lung-and-thoracic-surgery-patients
#17
Martijn Ten Berge, Naomi Beck, David Jonathan Heineman, Ronald Damhuis, Willem Hans Steup, Pieter Jan van Huijstee, Jan Peter Eerenberg, Eelco Veen, Alexander Maat, Michel Versteegh, Thomas van Brakel, Wilhemina Hendrika Schreurs, Michel Wilhelmus Wouters
BACKGROUND: The nationwide Dutch Lung Surgery Audit (DLSA) started in 2012 to monitor and evaluate the quality of lung surgery in the Netherlands as an improvement tool. This outline describes the establishment, structure and organization of the audit by the Dutch Society of Lung Surgeons (NVvL) and the Dutch Society of Cardiothoracic Surgeons (NVT), in collaboration with the Dutch Institute for Clinical Auditing (DICA). In addition, first four-year results are presented. METHODS: The NVvL and NVT initiated a web-based registration including weekly updated online feedback for participating hospitals...
April 21, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29683929/18f-fdg-pet-ct-in-the-evaluation-of-cancer-cervix-where-do-we-stand-today
#18
Shanmuga S Palaniswamy, Chaitanya R Borde, Padma Subramanyam
The incidence of gynecological malignancies is on the rise partly because of the availability of screening programmes, awareness, higher technological advancements, and availability of better medical care. Early diagnosis of any malignancy leads to prompt treatment. Use of 18Fluorine-Fluorodeoxyglucose (F-FDG) PET/CT in the treatment and follow-up of patients with Ca cervix considerably improves patient management. The primary diagnosis of Ca cervix is made either by biopsy of a visible tumor on the cervix or by a cone biopsy of a nonvisible malignant cervical focus...
April 20, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29664847/ovarian-cancer-surgery-in-australia-and-new-zealand-a-survey-to-determine-changes-in-surgical-practice-over-10-years
#19
Rhonda Farrell, Winston Spencer Liauw, Alison Hilary Brand
OBJECTIVE: This study aimed to survey all practicing certified gynecological oncologists (CGOs) in Australia and New Zealand to determine their current surgical practice for primary advanced epithelial ovarian cancer (EOC) and compare the findings with an identical survey conducted 10 years previously. METHODS/MATERIALS: A questionnaire was e-mailed to all 53 practicing CGOs in Australia and New Zealand in July 2017 assessing their definition of optimal debulking for EOC, their use of neoadjuvant chemotherapy, and the surgical procedures they use to achieve cytoreduction...
April 16, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29662832/hong-kong-consensus-statements-for-the-management-of-unresectable-hepatocellular-carcinoma
#20
Tom Tan-To Cheung, Philip Chong-Hei Kwok, Stephen Chan, Chin-Cheung Cheung, Ann-Shing Lee, Victor Lee, Hoi-Ching Cheng, Nam-Hung Chia, Charing C N Chong, Tak-Wing Lai, Ada L Y Law, Mai-Yee Luk, Chi Chung Tong, Thomas C C Yau
Background: Hepatocellular carcinoma (HCC) is highly prevalent in Hong Kong due to the high prevalence of chronic hepatitis B infection. Liver cancer is the fourth most common cancer and the third most common cause of cancer death. Due to the high case load, there is a high level of local expertise in treating HCC, and the full spectrum of treatment modalities is available. This document summarizes how these modalities should be used based on the latest evidence. Summary: In 2 meetings held in early 2017, a multidisciplinary group of Hong Kong clinicians, including liver surgeons, interventional radiologists, clinical oncologists, and medical oncologists, met to update local consensus statements for management of HCC...
March 2018: Liver Cancer
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