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https://www.readbyqxmd.com/read/29149150/the-hopeless-case-palliative-cryoablation-and-cementoplasty-procedures-for-palliation-of-large-pelvic-bone-metastases
#1
Tyler M Coupal, Kevin Pennycooke, Paul I Mallinson, Hugue A Ouellette, Paul W Clarkson, Pippa Hawley, Peter L Munk
BACKGROUND: Metastases to the bone are common in cancer patients, and it has been estimated that up to 50% of patients with pelvic bone metastases will not achieve adequate pain control with medications alone. This has led to a paradigm shift over recent years towards the use and development of minimally invasive image-guided treatment options for palliation of bony metastases. Despite these developments, large metastatic lesions are still often considered to be "hopeless cases" that would garner little to no benefit from image-guided intervention...
November 2017: Pain Physician
https://www.readbyqxmd.com/read/29147859/initial-psycho-oncological-counselling-in-neuro-oncology-analysis-of-topics-and-needs-of-brain-tumour-patients
#2
Stephanie Schipmann, Eric Suero Molina, Anna Frasch, Walter Stummer, Dorothee Wiewrodt
Diagnosis of a brain tumour is associated with a tremendous disruption of emotional, physical and social well-being. Due to the complexity of the disease and the affection of the central organ, the brain, brain tumour patients differ from other cancer patients. The purpose of this study was to evaluate the concerns and burdens presented by brain tumour patients during their initial psycho-oncological consultation. We performed a retrospective analysis of 53 patients with the diagnosis of either benign or malignant brain tumour, seeking counsel by a neurosurgeon specialised in psycho-oncology...
November 17, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29145553/tumour-boards-in-geriatric-oncology
#3
Tanya Marya Wildes, Anita O'Donovan, Giuseppe Ferdinando Colloca, Kwok-Leung Cheung
Multidisciplinary tumour board is an integral part of cancer treatment planning. Although no definite survival benefits have yet been shown by mostly observational studies, other benefits of multidisciplinary tumour board have been identified. Traditionally the multidisciplinary tumour board involves participation of treating clinicians-medical, radiation and surgical oncologists. They tend to focus on the cancer alone. There is an increasing awareness that the treatment goal for cancer in older adults is not primarily on prolonging survival, with functional preservation and quality of life being particularly important for this population...
November 14, 2017: Age and Ageing
https://www.readbyqxmd.com/read/29134472/real-time-wireless-tumor-tracking-during-breast-conserving-surgery
#4
Natasja Janssen, Roeland Eppenga, Marie-Jeanne Vrancken Peeters, Frederieke van Duijnhoven, Hester Oldenburg, Jos van der Hage, Emiel Rutgers, Jan-Jakob Sonke, Koert Kuhlmann, Theo Ruers, Jasper Nijkamp
PURPOSE: To evaluate a novel surgical navigation system for breast conserving surgery (BCS), based on real-time tumor tracking using the Calypso[Formula: see text] 4D Localization System (Varian Medical Systems Inc., USA). Navigation-guided breast conserving surgery (Nav-BCS) was compared to conventional iodine seed-guided BCS ([Formula: see text]I-BCS). METHODS: Two breast phantom types were produced, containing spherical and complex tumors in which wireless transponders (Nav-BCS) or a iodine seed ([Formula: see text]I-BCS) were implanted...
November 13, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/29124038/intraoperative-radiation-for-breast-cancer-with-intrabeam%C3%A2-factors-associated-with-decreased-operative-times-in-patients-having-iort-for-breast-cancer
#5
Stephanie A Valente, Alicia Fanning, Robyn A Stewart, Sharon Grundfest, Rahul D Tendulkar, Sheen Cherian, Chirag Shah, Chao Tu, Courtney Yanda, Diane Radford, Zahraa Al-Hilli, Stephen R Grobmyer
Introduction: Intraoperative radiation with Intrabeam™ (IORT) for breast cancer is a newer technology recently implemented into the operating room (OR). This procedure requires time and coordination between the surgeon and radiation oncologist, who both perform their treatments in a single operative setting. We evaluated the surgeons at our center, who perform IORT and their OR times to examine changes in OR times following implementation of this new surgical procedure. We hypothesized that IORT is a technique for which timing could be improved with the increasing number of cases performed...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/29089810/training-oncoplastic-breast-surgeons-the-canadian-fellowship-experience
#6
J Maxwell, A Arnaout, R Hanrahan, M Brackstone
BACKGROUND: Oncoplastic breast surgery combines traditional oncologic breast conservation with plastic surgery techniques to achieve improved aesthetic and quality-of-life outcomes without sacrificing oncologic safety. Clinical uptake and training remain limited in the Canadian surgical system. In the present article, we detail the current state of oncoplastic surgery (ops) training in Canada, the United States, and worldwide, as well as the experience of a Canadian clinical fellow in ops...
October 2017: Current Oncology
https://www.readbyqxmd.com/read/29078657/materials-and-techniques-in-chest-wall-reconstruction-a-review
#7
REVIEW
Stefano Sanna, Jury Brandolini, Alessandro Pardolesi, Desideria Argnani, Marta Mengozzi, Andrea Dell'Amore, Piergiorgio Solli
Extensive chest wall resection and reconstruction are a challenging procedure that requires a multidisciplinary approach, including input from thoracic surgeon, plastic surgeon and oncologist. In particular chest wall neoplastic pathology is associated with high surgical morbidity and can result in full thickness defects hard to reconstruct. The goals of a successful chest wall reconstruction are to restore the chest wall rigidity, preserve pulmonary mechanic and protect the intrathoracic organs minimizing the thoracic deformity...
2017: J Vis Surg
https://www.readbyqxmd.com/read/29072665/-granulomatosis-with-polyangiitis-associated-with-the-cytoplasmic-antineutrophil-antibodies
#8
A I Kryukov, G P Bondareva, O M Kurbacheva, V A Utesheva
The objective of the present work was to analyze the clinical case of granulomatosis with polyangiitis associated with the presence of cytoplasmic antineutrophil antibodies. We considered the medical records of the patient presenting with this condition. It was shown that systemic vasculitis had a polymorphic clinical picture; its diagnostics and treatment encountered serious difficulties. It is concluded that the development of progressive perforation of the nasal septum and destructive changes in the intranasal and adjacent structures after the endonasal surgical intervention implies the necessity of the detailed analysis of the clinical and laboratory observations with the subsequent counselling by a rheumatologist and oncologist for the clarification of the diagnosis and the choice of adequate therapy...
2017: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/29050111/-a-long-term-follow-up-report-of-pediatric-relapsed-wilms-tumor-after-retreatment
#9
T Y Wang, C Pan, Y J Gao, W T Hu, Q D Ye, M Zhou, J Y Tang
Objective: To investigate the long-term efficacy and prognostic factors of pediatric relapsed Wilms tumor (WT) after retreatment. Method: Sixteen children in Shanghai Children's Medical Center with relapsed Wilms tumor were enrolled consecutively in this study between April 2006 and June 2016. All patients were diagnosed according to pathology, imaging and medical and surgical oncologist's assistance. Relapse treatment included surgical excision, chemotherapy and selective radiation therapy. The clinical features, long-term outcomes and prognostic factors of patients were analyzed retrospectively...
October 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29048991/impacts-of-early-guideline-directed-21-gene-recurrence-score-testing-on-adjuvant-therapy-decision-making
#10
Hannah Dzimitrowicz, Sarah Mougalian, Sherri Storms, Sandra Hurd, Anees B Chagpar, Brigid K Killelea, Nina R Horowitz, Donald R Lannin, Malini Harigopal, Erin Hofstatter, Michael P DiGiovanna, Kerin B Adelson, Andrea Silber, Maysa Abu-Khalaf, Gina Chung, Wajih Zaheer, Osama Abdelghany, Christos Hatzis, Lajos Pusztai, Tara B Sanft
PURPOSE: The 21-gene recurrence score (RS) assay is used to help formulate adjuvant chemotherapy recommendations for patients with estrogen receptor-positive, early-stage breast cancer. Most frequently, medical oncologists order RS after surgery. Results take an additional 2 weeks to return, which can delay decision making. We conducted a prospective quality-improvement project to assess the impact of early guideline-directed RS ordering by surgeons before the first visit with a medical oncologist on adjuvant therapy decision making...
October 19, 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29040196/carcinoid-syndrome-complicating-a-pancreatic-neuroendocrine-tumor-a-case-report
#11
James N Gerson, Ronald M Witteles, Daniel T Chang, Ramin E Beygui, Andrei H Iagaru, Pamela L Kunz
Neuroendocrine tumors (NETs) comprise a heterogeneous group of neoplasms. These tumors can produce a wide variety of hormones that can lead to syndromes of hormone excess, such as carcinoid syndrome. We present the case of a 47-year-old man who presented with right upper quadrant abdominal pain and emesis. He was found to have metastatic pancreatic NET and was treated with systemic chemotherapy. He subsequently developed dyspnea on exertion and was found to have severe right-sided heart disease secondary to elevated levels of serum serotonin...
November 2017: Pancreas
https://www.readbyqxmd.com/read/29038849/malignant-bone-tumors-other-than-ewing-s-clinical-practice-guidelines-for-diagnosis-treatment-and-follow-up-by-spanish-group-for-research-on-sarcomas-geis
#12
Andrés Redondo, Silvia Bagué, Daniel Bernabeu, Eduardo Ortiz-Cruz, Claudia Valverde, Rosa Alvarez, Javier Martinez-Trufero, Jose A Lopez-Martin, Raquel Correa, Josefina Cruz, Antonio Lopez-Pousa, Aurelio Santos, Xavier García Del Muro, Javier Martin-Broto
Primary malignant bone tumors are uncommon and heterogeneous malignancies. This document is a guideline developed by the Spanish Group for Research on Sarcoma with the participation of different specialists involved in the diagnosis and treatment of bone sarcomas. The aim is to provide practical recommendations with the intention of helping in the clinical decision-making process. The diagnosis and treatment of bone tumors requires a multidisciplinary approach, involving as a minimum pathologists, radiologists, surgeons, and radiation and medical oncologists...
October 16, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29037531/cytoreductive-nephrectomy-a-medical-oncologist-s-perspective
#13
Nazli Dizman, Manuel Caitano Maia, Sumanta K Pal
The role of cytoreductive nephrectomy (CN) was firmly established in the cytokine era on the basis of 2 randomized studies employing adjunctive interferon therapy. However, systemic therapy for metastatic renal cell carcinoma has evolved markedly over the past decade, with targeted therapies representing the standard of care in the front-line setting. The preponderance of retrospective data generated to date appears to suggest that the benefit of CN is maintained in the targeted therapy era. However, these studies are inherently prone to selection bias and cannot substitute prospective evidence...
May 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28975111/human-papillomavirus-in-head-and-neck-cancer-in-india-current-status-and-consensus-recommendations
#14
REVIEW
Vedang Murthy, Adnan Calcuttawala, Kirti Chadha, Anil d'Cruz, Arvind Krishnamurthy, Indranil Mallick, Sudhir Nair, Tanuja Teni, Sagar Pawar, Kaustav Talapatra, Asawari Patil, Amit Bhatt, Sanjoy Chatterjee, Monali Swain, Prasad Narayanan, Nikhil Ghadyalpatil, Manish Singhal, Moni Kuriakose, Kumar Prabhash, Jaiprakash Agarwal, Purvish Parikh
Human papillomavirus (HPV) associated head and neck squamous cell cancers (HNSCC) have become increasingly common in the West, but the same cannot be said about India. These cancers have a different biology and confer a better prognosis, however, its current role in the management of patients in India is not clearly defined. At the 35(th) Indian Cooperative Oncology Network conference held in September 2016, a panel of radiation, surgical and medical oncologists, pathologists, and basic scientists from across the country having experience in clinical research with respect to HPV in HNSCC reviewed the available literature from India...
July 2017: South Asian Journal of Cancer
https://www.readbyqxmd.com/read/28972833/management-of-patients-with-stage-i-lung-cancer
#15
Jeffrey A Bogart, Jason Wallen
The treatment of stage I non-small-cell lung cancer has advanced markedly over the past century. The transition from therapeutic nihilism with ensured mortality to radical surgery with pneumonectomy to rational oncologic-based resection has resulted in dramatically improved outcomes and reduced morbidity. The superiority of anatomic resection with lobectomy over sublobar resection for fit patients with stage I disease, where more than one half of all patients should expect to be cured, is backed by level 1 evidence...
February 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/28967564/multidisciplinary-international-survey-of-post-operative-radiation-therapy-practices-after-nipple-sparing-or-skin-sparing-mastectomy
#16
Gustavo Nader Marta, Philip Poortmans, Alfredo C de Barros, José Roberto Filassi, Ruffo Freitas Junior, Riccardo A Audisio, Max Senna Mano, Sarkis Meterissian, Sarah M DeSnyder, Thomas A Buchholz, Tarek Hijal
PURPOSE/OBJECTIVE(S): Skin sparing mastectomy (SSM) and nipple-sparing mastectomy (NSM) have entered routine surgical practice for breast cancer, though their oncologic safety has not been established in randomized controlled trials. The aim of this study was to evaluate and compare radiation oncologists' and breast surgeons' opinions concerning the indications of post-operative radiation therapy (PORT) after SSM and NSM. MATERIALS/METHODS: Radiation oncologists and breast surgeons from North America, South America and Europe were invited to contribute in this study...
September 19, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28966917/advances-on-immunotherapy-in-genitourinary-and-renal-cell-carcinoma
#17
Gregory P Botta, Eric Granowicz, Carrie Costantini
Genitourinary (GU) cancers are a group of epithelial malignancies associated with the organs involved in the excretion of urine. Renal cell, urothelial, and prostatic carcinoma are the overwhelming subtypes diagnosed by oncologists. Each of these was traditionally treated surgically when local and non-invasive. When these carcinomas spread, invade, or metastasize, surgical control lacks in efficacy. Chemotherapeutic regimens have been implemented for decades and have increased overall survival but many patients progress...
February 2017: Translational Cancer Research
https://www.readbyqxmd.com/read/28958177/use-of-minimally-invasive-spine-surgical-instruments-for-the-treatment-of-bone-tumors
#18
Russell A Reeves, Matthew C DeWolf, Peter J Shaughnessy, James B Ames, Eric R Henderson
Orthopedic oncologists often encounter patients with minor bony lesions that are difficult to access surgically and therefore require large exposures out of proportion to the severity of disease that confer significant patient morbidity. Minimally invasive surgical techniques offer the advantage of smaller incisions, shorter operative times, decreased tissue damage, and decreased costs. A variety of surgical procedures have emerged using minimally invasive technologies, particularly in the field of spine surgery...
October 4, 2017: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/28945830/patient-derived-xenografts-effectively-capture-responses-to-oncology-therapy-in-a-heterogeneous-cohort-of-patients-with-solid-tumors
#19
E Izumchenko, K Paz, D Ciznadija, I Sloma, A Katz, D Vasquez-Dunddel, I Ben-Zvi, J Stebbing, W McGuire, W Harris, R Maki, A Gaya, A Bedi, S Zacharoulis, R Ravi, L H Wexler, M O Hoque, C Rodriguez-Galindo, H Pass, N Peled, A Davies, R Morris, M Hidalgo, D Sidransky
Background: While patient-derived xenografts (PDXs) offer a powerful modality for translational cancer research, a precise evaluation of how accurately patient responses correlate with matching PDXs in a large, heterogeneous population is needed for assessing the utility of this platform for preclinical drug-testing and personalized patient cancer treatment. Patients and methods: Tumors obtained from surgical or biopsy procedures from 237 cancer patients with a variety of solid tumors were implanted into immunodeficient mice and whole-exome sequencing was carried out...
October 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28890435/pain-control-in-thoracic-oncology
#20
Christine Peeters-Asdourian, Gilbert Massard, Paragi H Rana, Paul Van Houtte, Andrew P White, Bogdan Grigoriu, Dominique Lossignol, Mohammed Almalki, Jean Alexiou, Jean-Luc Engelholm, Jean-Paul Sculier
This review of pain management in lung cancer is based on the presentation of four cases of thoracic oncology patients with pain at various stages of their disease. The approach will be multidisciplinary, involving a thoracic oncologist, radiologist, thoracic and orthopaedic spine surgeon, radiation therapist, pain medicine specialist, and palliative care specialist. This multispecialty approach to the management of different painful presentations in thoracic oncology will demonstrate the complexity of each case and the improved patient outcomes which result from the involvement of different disciplines working in concert...
September 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
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