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JOURNAL ARTICLE
Caroline Melhado, Rachelle Durand, Katie W Russell, Natalya E Polukoff, John Rampton, Rajiv R Iyer, Shannon N Acker, Richele Koehler, Connor Prendergast, Nicholas Stence, Brent O'Neill, Benjamin E Padilla, Ramin Jamshidi, Jennifer A Vaughn, Jennifer S Ronecker, Leigh Selesner, Katrine Lofberg, Michael Regner, Jaclyn Thiessen, Christine Sayama, Ryan G Spurrier, Erin E Ross, Chia-Shang Jason Liu, Jason Chu, Kathryn McNevin, Catherine Beni, Bryce R H Robinson, Ken Linnau, Robert T Buckley, Stephanie D Chao, Akanksha Sabapaty, Elizabeth Tong, Laura M Prolo, Romeo Ignacio, Gretchen Floan Sachs, Peter Kruk, David Gonda, Mark Ryan, Samir Pandya, Korgun Koral, Bruno P Braga, Kurtis Auguste, Aaron R Jensen
INTRODUCTION: Clinical clearance of a child's cervical spine after trauma is often challenging due to impaired mental status or an unreliable neurologic examination. Magnetic resonance imaging (MRI) is the gold standard for excluding ligamentous injury in children but is constrained by long image acquisition times and frequent need for anesthesia. Limited-sequence MRI (LSMRI) is used in evaluating the evolution of traumatic brain injury and may also be useful for cervical spine clearance while potentially avoiding the need for anesthesia...
March 25, 2024: Journal of Trauma and Acute Care Surgery
#2
JOURNAL ARTICLE
Gabriela D Ruiz Colón, Sylvia Bereknyei Merrell, Diana C Poon, Kelly B Mahaney, Cormac O Maher, Laura M Prolo
OBJECTIVE: In the United States, Spanish is the second most spoken language, with nearly 42 million individuals speaking Spanish at home. Spanish speakers have been noted to have higher rates of unfavorable neurosurgical outcomes; however, to the authors' knowledge, no study has explored the experiences of patients, caregivers, and providers receiving or delivering neurosurgical care in language-discordant settings. In this study, the authors sought to identify challenges faced by pediatric neurosurgery providers and Spanish-speaking parents communicating with a language barrier and propose solutions to address those challenges...
March 22, 2024: Journal of Neurosurgery. Pediatrics
#3
JOURNAL ARTICLE
Brendan S Kelly, Prateek Mathur, Silvia D Vaca, John Duignan, Sarah Power, Edward H Lee, Yuhao Huang, Laura M Prolo, Kristen W Yeom, Aonghus Lawlor, Ronan P Killeen, John Thornton
PURPOSE: This study aimed to develop and evaluate a machine learning model and a novel clinical score for predicting outcomes in stroke patients undergoing endovascular thrombectomy. MATERIALS AND METHODS: This retrospective study included all patients aged over 18 years with an anterior circulation stroke treated at a thrombectomy centre from 2010 to 2020 with external validation. The primary outcome was day 90 mRS ≥3. Existing clinical scores (SPAN and PRE) and Machine Learning (ML) models were compared...
February 15, 2024: European Journal of Radiology
#4
REVIEW
Gabriela D Ruiz Colón, Maria Isabel Barros Guinle, Adela Wu, Gerald A Grant, Laura M Prolo
OBJECTIVE: In 2019, 22% of adults in the United States reported speaking a language other than English at home, representing 52% growth since 2000. This diversity in languages - and resulting possible communication barriers - represents a potential challenge to effective care. In this manuscript, we summarize clinical outcomes and healthcare utilization patterns of adult and pediatric neurosurgical patients who are non-English primary language speakers (NEPLS). METHODS: We systematically queried five databases from inception through October 2022...
February 20, 2024: World Neurosurgery
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JOURNAL ARTICLE
Eric W Prince, John R Apps, John Jeang, Keanu Chee, Stephen Medlin, Eric M Jackson, Roy Dudley, David Limbrick, Robert Naftel, James Johnston, Neil Feldstein, Laura M Prolo, Kevin Ginn, Toba Niazi, Amy Smith, Lindsay Kilburn, Joshua Chern, Jeffrey Leonard, Sandi Lam, David S Hersh, Jose Mario Gonzalez-Meljem, Vladimir Amani, Andrew M Donson, Siddhartha S Mitra, Pratiti Bandohpadhayay, Juan Pedro Martinez-Barbera, Todd C Hankinson
BACKGROUND: Cellular senescence can have positive and negative effects on the body, including aiding in damage repair and facilitating tumor growth. Adamantinomatous Craniopharyngioma (ACP), the most common pediatric sellar/suprasellar brain tumor, poses significant treatment challenges. Recent studies suggest that senescent cells in ACP tumors may contribute to tumor growth and invasion by releasing a Senesecence-Associated Secretory Phenotype (SASP). However, a detailed analysis of these characteristics has yet to be completed...
February 9, 2024: Neuro-oncology
#6
JOURNAL ARTICLE
Ana Clara Casella, Carolina Prolo, Josefina Pereyra, Natalia Ríos, Lucía Piacenza, Rafael Radi, María Noel Álvarez
Macrophages count on two O2 -consuming enzymes to form reactive radical species: NAPDH oxidase 2 (Nox2) and nitric oxide synthase 2 (inducible isoform, iNOS) that produce superoxide radical (O2 •- ) and nitric oxide (• NO), respectively. If formed simultaneously, the diffusion-controlled reaction of O2 •- and • NO yields peroxynitrite, a potent cytotoxic oxidant. In human tissues and cells, the oxygen partial pressure (pO2 ) normally ranges within 2-14 %, with a typical average pO2 value for most tissues ca...
December 21, 2023: Free Radical Biology & Medicine
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JOURNAL ARTICLE
M A L Ribeiro, S A L Ribeiro, P R Prado, S L Prolo Júnior, C M Carvalho, D U O Meneguetti, M A L Ribeiro
Fungi exhibit three adverse effects on human health: inflammatory, allergic and toxic effects, these implications affect mainly immunodepressed patients. The objective of this work was to analyze the fungal microbiota of the ambient air of an Intensive Care Unit. Three collections were carried out in an Intensive Care Unit in the city of Rio Branco, Acre, Western Amazon, Brazil from March to May 2017. 126 Petri dishes were exposed with the culture medium Agar Sabouraud with chloramphenicol and Agar Mycosel, considering the distribution of the 21 air conditioners, split residential model...
2023: Brazilian Journal of Biology
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JOURNAL ARTICLE
Adela Wu, Michael C Jin, Hannes Vogel, Susan Hiniker, Cynthia Campen, Laura M Prolo, Gerald A Grant
Introduction There is no standard treatment paradigm for intracranial teratomas, a rare subset of primary intracranial nongerminomatous germ cell tumors (NGGCT), which comprise less than 1% of pediatric brain tumors. This case series retrospectively analyzes treatment and outcomes of pediatric intracranial teratomas from a single institution. Methods Authors reviewed a comprehensive pathology database at Stanford's Lucile Packard Children's Hospital for intracranial teratomas in pediatric patients treated from 2006-2021...
October 25, 2023: Pediatric Neurosurgery
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JOURNAL ARTICLE
Simone Delgado Tojal, Ivaneide Nunes da Costa, André de Abreu Rangel Aguirre, Thiago Fernandes Martins, Marcelo Bahia Labruna, Dionatas Ulises de Oliveira Meneguetti, Paulo Sérgio Bernarde, Karoline Silva da Cruz, Jônatas Machado Lima, Sergio Luiz Prolo Júnior, Luís Marcelo de Aranha Camargo
The aim of the present study was to report on the occurrence of parasitism by Amblyomma rotundatum ticks on two species of Teiidae lizards and test the presence of rickettsiae in the collected ticks, in the western Brazilian Amazon region. Ticks were collected in July 2019, from a fragment of terra firme forest in the municipality of Senador Guiomard, Acre, Brazil. Two lizards that were infested by immature stages of ticks were caught using mist net and Tomahawk traps. Ectoparasites were collected manually, and the lizard specimens were identified and released at the same location where they had been caught...
2023: Brazilian Journal of Veterinary Parasitology
#10
JOURNAL ARTICLE
Gabriela D Ruiz Colón, Rebecca J Pizzitola, Gerald A Grant, Laura M Prolo
OBJECTIVE: To determine if differences exist in postoperative communication patterns or healthcare utilization among English-speaking patients (ESPs) and Spanish-speaking patients (SSPs) with childhood hydrocephalus. STUDY DESIGN: A single-institution, retrospective cohort study was conducted. Through simple random sampling, fifty ESPs and fifty SSPs (<18 years old) who underwent a ventriculoperitoneal shunt (VPS) or endoscopic third ventriculostomy (ETV) were identified...
August 21, 2023: Journal of Pediatrics
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JOURNAL ARTICLE
Vera Vigo, Jose E Chang, Maximiliano A Nunez, Laura M Prolo, Peter H Hwang, Juan C Fernandez-Miranda
INDICATIONS CORRIDOR AND LIMITS OF EXPOSURE: The endoscopic endonasal transtuberculum approach grants access to suprasellar and retrochiasmatic lesions with hypothalamic involvement. Here, we present a case of a 13-year-old boy with a history of stunted growth, decreased vision, headaches, and low energy with a tuberoinfundibular craniopharyngioma. The patient consented to the procedure. ANATOMIC ESSENTIALS NEED FOR PREOPERATIVE PLANNING AND ASSESSMENT: Evaluation of the sphenoid sinus pneumatization, internal carotid artery disposition, presence of clinoidal rings, variations of the infrachiasmatic corridor (optic chiasm location, height of dorsum sella), and location of the pituitary stalk are crucial for surgical strategy...
June 23, 2023: Operative Neurosurgery (Hagerstown, Md.)
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JOURNAL ARTICLE
Dana Tlais, Maria Isabel Barros Guinle, Joshua Riley Wheeler, Laura M Prolo, Hannes Vogel, Sonia Partap
No abstract text is available yet for this article.
2023: Neuro-oncology advances
#13
REVIEW
Jasia Mahdi, Jorg Dietrich, Karin Straathof, Claire Roddie, Brian J Scott, Tom Belle Davidson, Laura M Prolo, Tracy T Batchelor, Cynthia J Campen, Kara L Davis, Juliane Gust, Michael Lim, Robbie G Majzner, Julie R Park, Sonia Partap, Sneha Ramakrishna, Rebecca Richards, Liora Schultz, Nicholas A Vitanza, Leo D Wang, Crystal L Mackall, Michelle Monje
Cancer immunotherapies have unique toxicities. Establishment of grading scales and standardized grade-based treatment algorithms for toxicity syndromes can improve the safety of these treatments, as observed for cytokine release syndrome (CRS) and immune effector cell associated neurotoxicity syndrome (ICANS) in patients with B cell malignancies treated with chimeric antigen receptor (CAR) T cell therapy. We have observed a toxicity syndrome, distinct from CRS and ICANS, in patients treated with cell therapies for tumors in the central nervous system (CNS), which we term tumor inflammation-associated neurotoxicity (TIAN)...
April 2023: Nature Medicine
#14
REVIEW
Gabriela D Ruiz Colón, Adela Wu, John K Ratliff, Laura M Prolo
BACKGROUND: In 2001, the National Academy of Medicine, formerly known as the Institute of Medicine (IOM), published their seminal work, Crossing the Quality Chasm: A New Health System for the 21st Century. In this work, the authors called for improved safety, effectiveness, patient-centeredness, timeliness, efficiency, and equity in the United States' healthcare system. Two decades after the publication of this work, healthcare costs continue to rise, but outcomes lag other nations. The objective of this narrative review is to describe research efforts in pediatric neurosurgery with respect to the six quality aims proposed by the IOM, and highlight additional research opportunities...
January 25, 2023: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
#15
JOURNAL ARTICLE
Jena V Lilly, Jo Lynne Rokita, Jennifer L Mason, Tatiana Patton, Stephanie Stefankiewiz, David Higgins, Gerri Trooskin, Carina A Larouci, Kamnaa Arya, Elizabeth Appert, Allison P Heath, Yuankun Zhu, Miguel A Brown, Bo Zhang, Bailey K Farrow, Shannon Robins, Allison M Morgan, Thinh Q Nguyen, Elizabeth Frenkel, Kaitlin Lehmann, Emily Drake, Catherine Sullivan, Alexa Plisiewicz, Noel Coleman, Luke Patterson, Mateusz Koptyra, Zeinab Helili, Nicholas Van Kuren, Nathan Young, Meen Chul Kim, Christopher Friedman, Alex Lubneuski, Christopher Blackden, Marti Williams, Valerie Baubet, Lamiya Tauhid, Jamie Galanaugh, Katie Boucher, Heba Ijaz, Kristina A Cole, Namrata Choudhari, Mariarita Santi, Robert W Moulder, Jonathan Waller, Whitney Rife, Sharon J Diskin, Marion Mateos, Donald W Parsons, Ian F Pollack, Stewart Goldman, Sarah Leary, Chiara Caporalini, Anna Maria Buccoliero, Mirko Scagnet, David Haussler, Derek Hanson, Ron Firestein, Jason Cain, Joanna J Phillips, Nalin Gupta, Sabine Mueller, Gerald Grant, Michelle Monje-Deisseroth, Sonia Partap, Jeffrey P Greenfield, Rintaro Hashizume, Amy Smith, Shida Zhu, James M Johnston, Jason R Fangusaro, Matthew Miller, Matthew D Wood, Sharon Gardner, Claire L Carter, Laura M Prolo, Jared Pisapia, Katherine Pehlivan, Andrea Franson, Toba Niazi, Josh Rubin, Mohamed Abdelbaki, David S Ziegler, Holly B Lindsay, Ana Guerreiro Stucklin, Nicolas Gerber, Olena M Vaske, Carolyn Quinsey, Brian R Rood, Javad Nazarian, Eric Raabe, Eric M Jackson, Stacie Stapleton, Robert M Lober, David E Kram, Carl Koschmann, Phillip B Storm, Rishi R Lulla, Michael Prados, Adam C Resnick, Angela J Waanders
Pediatric brain tumors are the leading cause of cancer-related death in children in the United States and contribute a disproportionate number of potential years of life lost compared to adult cancers. Moreover, survivors frequently suffer long-term side effects, including secondary cancers. The Children's Brain Tumor Network (CBTN) is a multi-institutional international clinical research consortium created to advance therapeutic development through the collection and rapid distribution of biospecimens and data via open-science research platforms for real-time access and use by the global research community...
November 3, 2022: Neoplasia: An International Journal for Oncology Research
#16
JOURNAL ARTICLE
Elyn Wang, Paulina M Gutkin, Justin Oh, Erqi Pollom, Scott G Soltys, Gerald A Grant, Laura M Prolo, Steven Chang, Gordon Li, Paul G Fisher, Sonia Partap, Cynthia J Campen, Iris C Gibbs, Susan M Hiniker
OBJECTIVE: Recurrence of brain tumors in children after the initial course of treatment remains a problem. This study evaluated the efficacy and safety of reirradiation using stereotactic radiosurgery (SRS) in patients with recurrent pediatric primary brain tumors. METHODS: This IRB-approved retrospective review included pediatric patients with recurrent primary brain tumors treated at Stanford University from 2000 to 2019 using frameless SRS. Time to local failure (LF) and distant intracranial failure (DIF) were measured from the date of SRS and analyzed using competing risk analysis...
November 2022: Neurosurgical Focus
#17
JOURNAL ARTICLE
Martin Knight, James Inklebarger, Albert E Telfeian, Kai-Uwe Lewandrowski
BACKGROUND: Paravertebral cluneal nerves are constrained within a tunnel consisting of the thoracolumbar fascia and the iliac crest's superior rim as they pass over the iliac crest. Their involvement in low back pain has not been presented previously. OBJECTIVE: To develop a diagnostic and therapeutic protocol for radiofrequency ablation of paravertebral and iliac cluneal trigger points. STUDY DESIGN: In a prospective observational cohort study, clinically painful trigger points were anatomically defined with diagnostic local anesthetic injections containing a steroid...
October 2022: Pain Physician
#18
JOURNAL ARTICLE
L R Virgilio, G O Teixeira, L S Almeida, H P S Melo, S L Prolo Júnior, D U O Meneguetti, L M A Camargo, R M Takemoto
Trypanosoma is a hemoflagellate capable of infecting a wide variety of invertebrates and vertebrates, such as Neotropical freshwater fish. The present study described and morphologically compared Trypanosoma spp., found in Platydoras armatulus , Valenciennes, 1840, in southwestern Amazon. Fish specimens were sampled in Ipixuna and Juruá rivers located in the states of Amazonas and Acre, Brazil. Fish blood samples were taken by cardiac puncture, and smears were prepared for quantification, morphometric measurements, and morphotyping (characterization of the trypanosomes according to their morphological variations) of trypanosomes found...
September 2022: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
#19
JOURNAL ARTICLE
Yongjian Gao, Chen Zhao, Lei Luo, Liehua Liu, Lichuan Liang, Dianming Jiang, Pei Li, Qiang Zhou
Background: Although direct pars repair using a pedicle screw-rod-hook system has achieved satisfactory results in patients with spondylolysis, its application in adults with low-grade isthmic spondylolisthesis is rarely reported. Objective: To assess the surgical effect of reduction and direct repair surgery with a pedicle screw-rod-hook system combined with autogenous bone grafts in adult patients with low-grade isthmic spondylolisthesis. Methods: Sixty-four adult patients with low-grade isthmic spondylolisthesis underwent reduction and direct repair using a pedicle screw-rod-hook system in our department from September 2009 to April 2018...
2022: Pain Research & Management
#20
JOURNAL ARTICLE
Vincent Jecko, Marie-Pierre Loit, Deborah Houston, Charles Champeaux-Depond
Study Design: A multicenter cross-sectional analytical retrospective study. Purpose: To assess functional outcome (FO) after a spinal meningioma (SM) surgery. Overview of Literature: All studies report functional improvement after SM removal. Methods: We performed an analytical retrospective cohort study at five different institutions. All patients with a diagnosis of SM were included in this study, including those with recurrent tumors...
June 3, 2022: Asian Spine Journal
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