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Natalia Rios, Lucía Piacenza, Madia Trujillo, Alejandra Martínez, Verónica Demicheli, Carolina Prolo, María Noel Álvarez, Gloria V López, Rafael Radi
The specific and sensitive detection of peroxynitrite (ONOO(-)/ONOOH) in biological systems is a great challenge due to its high reactivity towards several biomolecules. Herein, we validated the advantages of using fluorescein-boronate (Fl-B) as a highly sensitive fluorescent probe for the direct detection of peroxynitrite under biologically-relevant conditions in two different cell models. The synthesis of Fl-B was achieved by a very simply two-step conversion synthetic route with high purity (>99%) and overall yield (∼42%)...
September 15, 2016: Free Radical Biology & Medicine
Giovanna Muscogiuri, Daniela Mari, Silvia Prolo, Letizia M Fatti, Maria Celeste Cantone, Paolo Garagnani, Beatrice Arosio, Carolina Di Somma, Giovanni Vitale
BACKGROUND: Low 25(OH) vitamin D levels have been associated with several autoimmune diseases and recently with autoimmune thyroiditis (AT). The aim of the study was to investigate the association of AT with low 25(OH) vitamin D levels in the elderly. METHODS: One hundred sixty-eight elderly subjects (mean age: 81.6 ± 9.4 years) were enrolled. Serum levels of 25(OH) vitamin D, anti-thyroid peroxidase (TPO-Ab), anti-thyroglobulin (TG-Ab) antibodies, free triiodothyronine (FT3), free thyroxine (FT4) and thyroid stimulating hormone (TSH) were measured...
2016: International Journal of Environmental Research and Public Health
H G Ternavasio-de la Vega, A Barbosa Ventura, F Castaño-Romero, F D Sauchelli, A Prolo Acosta, F J Rodríguez Alcázar, A Vicente Sánchez, E Ruiz Antúnez, M Marcos, J Laso
BACKGROUND: Catheter-associated urinary tract infections (CAUTIs) represent an important healthcare burden. AIM: To assess the effectiveness of an evidence-based multi-modal, multi-disciplinary intervention intended to improve outcomes by reducing the use of urinary catheters (UCs) and minimizing the incidence of CAUTIs in the internal medicine department of a university hospital. METHODS: A multi-modal intervention was developed, including training sessions, urinary catheterization reminders, surveillance systems, and mechanisms for staff feedback of results...
October 2016: Journal of Hospital Infection
Do-Keun Kim, Hyunkeun Lim, Dae Cheol Rim, Chang Hyun Oh
OBJECTIVE: Spinal fusion operation is an effective treatment in the spinal pathology, but it could change the physiological distribution of load at the instrumented and adjacent segments. This retrospective study compared the radiological and clinical outcomes of patients undergoing lumbar fusion with semirigid rods versus rigid rods system. METHODS: Using transpedicular fixation and posterior lumbar interbody fusion at the level of L4/L5, 20 patients were treated with semirigid rods (WavefleX, SR group), and 20 patients with rigid rods (titanium, RR group)...
June 2016: Korean Journal of Spine
Andrea Galassi, Maria Enrica Giovenzana, Federico Prolo, Anna Maria Colombo, Luciano Orsi, Sergio Fucci, Loredana Sorbara, Silvia Viganò, Chiara Clementi, Susi Falcaro, Sara Auricchio, Beatrice Dozio, Renzo Scanziani
The rate of fragile elderly patients affected by chronic kidney disease stage 5-5D is rapidly increasing. The decision making process regarding the start and the withdrawal of dialysis is often difficult for all those involved: patients, relatives, nephrologists and renal nurses. Therefore nephrologists and renal nurses are called to rapidly improve their theoretical and practical competence about the end-of-life care. The quality of clinical intervention and management requires a sound expertise in the ethical, legal, organizational and therapeutic aspects, not trivial nor even deductible from purely private and individual opinions nor from traditional medical practice...
May 2016: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
Kadir Kotil
STUDY DESIGN: A review of clinical and radiological outcomes of lumbar laminoplasty (LL) for the treatment of isthmic spondylolisthesis (ISL). PURPOSE: The single session performance of posterior lumbar interbody fusion with allograft in the anterior column and providing the realignment of the vertebrae was presented as a preliminary report earlier. OVERVIEW OF LITERATURE: Long-term surgical outcome of cervical laminoplasty in patients has been reported...
June 2016: Asian Spine Journal
Gurpreet S Gandhoke, Manish K Kasliwal, Justin S Smith, JoAnne Nieto, David Ibrahimi, Paul Park, Frank Lamarca, Christopher Shaffrey, David O Okonkwo, Adam S Kanter
OBJECTIVE: A retrospective review of the clinical and radiographic outcomes from a multi-center study of surgical treatment for high-grade spondylolisthesis (HGS) in adults. The objective was to assess the safety of surgical reduction, its ability to correct regional deformity, and its clinical effectiveness. METHODS: Retrospective, multi-center review of adults (age >18 y) with lumbo-sacral HGS (Meyerding grade 3-5) treated surgically with open decompression, attempted reduction, posterior instrumentation and interbody fusion...
June 20, 2016: Clinical Spine Surgery
Ujjwal Gowardhan Wankhade, Mahesh Kotehal Umashankar, B S Jayakrishna Reddy
INTRODUCTION: Low back pain affects every population and is one of world's foremost debilitating conditions. Clinically significant sciatica due to lumbar disc prolapse occurs in 4-6% of population. Fenestration discectomy as a surgical procedure is less time consuming, with lesser blood loss, lesser post-operative complications and does not compromise with stability of spine when compared to laminectomy. AIM: Present study was conducted to determine extent of functional recovery i...
March 2016: Journal of Clinical and Diagnostic Research: JCDR
Roshan Bhaisare, Bhavna Kamble, Kisan Patond
STUDY DESIGN: Prospective study. PURPOSE: The aim of the study was to present long-term results from a 10-year follow-up after endoscopic lumbar discectomy (ELD) by "Destandau's technique". OVERVIEW OF LITERATURE: Endoscopic disc surgery by Destandau's technique using ENDOSPINE Karl Storz system is a relatively new technique. It was introduced in 1993. It has been gaining popularity among the spine surgeons, as it is attractive for small skin incision and allows a gentle and excellent tissue dissection with excellent visualization...
April 2016: Asian Spine Journal
Karsten Schöller, Thomas Steingrüber, Marco Stein, Nina Vogt, Tilman Müller, Jörn Pons-Kühnemann, Eberhard Uhl
BACKGROUND: The microsurgical unilateral laminotomy (MUL) technique for bilateral decompression of lumbar spinal stenosis (LSS) is a less destabilizing alternative to laminectomy and leads to good short-term outcomes. However, little is known about the long-term results including predictive factors. METHODS: Medical records of patients who underwent MUL for LSS decompression between 2005 and 2010 were reviewed, and a questionnaire was distributed to complement the long-term outcome data...
June 2016: Acta Neurochirurgica
Niels Buchmann, Alexander Preuß, Jens Gempt, Yu-Mi Ryang, Martin Vazan, Michael Stoffel, Bernhard Meyer, Florian Ringel
PURPOSE: There is a lack of studies highlighting the outcome by different scores or parameters after surgery for recurrent disc herniations of the lumbar spine at the initial herniation site. This study assessed the quality of life after surgical treatment of recurrent herniations with different standardized validated outcome instruments. METHODS: During a 24-month period, 64 patients underwent (microscope assisted) surgery for recurrent disc herniations of the lumbar spine...
May 2016: World Neurosurgery
Pyung Goo Cho, Gyu Yeul Ji, Dong Ah Shin, Yoon Ha, Do Heum Yoon, Keung Nyun Kim
PURPOSE: Our purpose was to evaluate the efficacy of teriparatide for posterior lumbar interbody fusion (PLIF) in osteoporotic women. METHODS: Forty-seven osteoporotic patients underwent PLIF with pedicle screw fixation for degenerative lumbar stenosis and instability. Patients were divided into two groups. The teriparatide group (n = 23) was injected subcutaneously with teriparatide (20 μg daily) for 3-month cycles alternating with 3-month periods of oral sodium alendronate for 12 months...
December 10, 2015: European Spine Journal
M K Ahsan, N Sakeb
Out of wide range of surgical techniques direct repair techniques are emphasized to avoid fusion related complications in pars defects. To assess the clinical, functional and radiological outcome of direct operative repair of pars defects by intra-laminar screws and bone graft, this retrospective study was done in Bangabandhu Sheikh Mujib Medical University and in our private settings, within the period of July 2005 to December 2012. Records of 12 patients (age range, 21-35 years) with symptomatic pars defect, 07 men and 05 women (mean 28 years) who underwent direct pars repair with intralaminar screws and bone graft were reviewed...
July 2015: Mymensingh Medical Journal: MMJ
Carolina Prolo, María Noel Álvarez, Natalia Ríos, Gonzalo Peluffo, Rafael Radi, Natalia Romero
Macrophage-derived nitric oxide ((•)NO) participates in cytotoxic mechanisms against diverse microorganisms and tumor cells. These effects can be mediated by (•)NO itself or (•)NO-derived species such as peroxynitrite formed by its diffusion-controlled reaction with NADPH oxidase-derived superoxide radical anion (O(2)(•-)). In vivo, the facile extracellular diffusion of (•)NO as well as different competing consumption routes limit its bioavailability for the reaction with O(2)(•-) and, hence, peroxynitrite formation...
October 2015: Free Radical Biology & Medicine
Steven J McAnany, Jun S Kim, Samuel C Overley, Evan O Baird, Paul A Anderson, Sheeraz A Qureshi
BACKGROUND CONTEXT: The posterior cervical foraminotomy (PCF) may be performed using an open or minimally-invasive (MIS) approach using a tubular retractor. Although there are theoretical advantages such as less blood loss and shorter hospitalizations, there is no consensus in the literature regarding the best approach for treatment. PURPOSE: To assess clinical outcomes of PCF treated with either an open or an MIS approach using a tubular retractor. STUDY DESIGN: Systematic literature review and meta-analysis of English language studies for the treatment of cervical radiculopathy treated with foraminotomy...
May 1, 2015: Spine Journal: Official Journal of the North American Spine Society
Yohan Song, Suzanne Tharin, Vasu Divi, Laura M Prolo, Davud B Sirjani
BACKGROUND: Transcervical approaches to the upper cervical spine are challenging because several upper anterior neurovascular structures need to be displaced to provide access. Although various techniques have been described, the anterolateral approach is one of the safest and most effective methods available to access the anterior C2-C3 disc space. Despite the approach's efficacy, however, it can cause postoperative complications because of, at least partly, the inter-surgeon differences in the methods by which the larynx and hypopharynx are displaced medially...
September 2015: Head & Neck
Gurpreet S Gandhoke, Manish K Kasliwal, Justin S Smith, JoAnne Nieto, David Ibrahimi, Paul Park, Frank Lamarca, Christopher Shaffrey, David O Okonkwo, Adam S Kanter
OBJECTIVE: A retrospective review of the clinical and radiographic outcomes from a multi-center study of surgical treatment for high-grade spondylolisthesis (HGS) in adults. The objective was to assess the safety of surgical reduction, its ability to correct regional deformity, and its clinical effectiveness. METHODS: Retrospective, multi-center review of adults (age >18 y) with lumbo-sacral HGS (Meyerding grade 3-5) treated surgically with open decompression, attempted reduction, posterior instrumentation and interbody fusion...
October 31, 2014: Journal of Spinal Disorders & Techniques
Saeid Karamouzian, Ali Ebrahimi-Nejad, Shahram Shahsavarani, Ehsan Keikhosravi, Mohsen Shahba, Farzaneh Ebrahimi
STUDY DESIGN: Prospective study. PURPOSE: We compared the effects of two methods of epidural steroid injection in patients with recurrent disc herniation. OVERVIEW OF LITERATURE: To our knowledge, there is no previous report of such a comparison in these patients. METHODS: The study was performed with 30 patients with relapsed lumbar disc herniation whose pain was not relieved by conservative remedies. The patients were divided into two groups, each of 15 patients, and entered the study for caudal or transforaminal injections...
October 2014: Asian Spine Journal
Nattawat Witoon, Teera Tangviriyapaiboon
STUDY DESIGN: A retrospective study. PURPOSE: To investigate clinical and radiological outcomes when using spinous process as a tricortical autograft for segmental spinal fusion in transforaminal lumbar interbody fusion (TLIF). OVERVIEW OF LITERATURE: Interbody spinal fusion is one of the important procedures in spinal surgery. Many types of autografts are harvested at the expense of complications. Clinical and radiographic results of patients who underwent TLIF with intraoperative harvested spinous process autograft in Prasat Neurological Institue, Bangkok, Thailand, were assessed as new technical innovation...
April 2014: Asian Spine Journal
Ilias N Caralopoulos, Cuong J Bui
BACKGROUND: Degenerative lumbar stenosis associated with spondylolisthesis is common in elderly patients. The most common symptoms are those of neurogenic claudication with leg pain. Surgery is indicated for those who fail conservative management. The generally accepted recommendation is to perform a laminectomy and a fusion at the involved level. METHODS: We reviewed our results for minimally invasive single-level decompression without fusion performed by the senior author in patients with symptomatic lumbar stenosis with spondylolisthesis with no dynamic instability from 2008 to 2011 at a single institution...
2014: Ochsner Journal
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