Mikhail Yu Vyssokikh, Maksim A Vigovskiy, Vladislav V Philippov, Yakov R Boroday, Mariya V Marey, Olga A Grigorieva, Tatiana F Vepkhvadze, Nadezhda S Kurochkina, Ludmila A Manukhova, Anastasiya Yu Efimenko, Daniil V Popov, Vladimir P Skulachev
A decrease in muscle mass and its functionality (strength, endurance, and insulin sensitivity) is one of the integral signs of aging. One of the triggers of aging is an increase in the production of mitochondrial reactive oxygen species. Our study was the first to examine age-dependent changes in the production of mitochondrial reactive oxygen species related to a decrease in the proportion of mitochondria-associated hexokinase-2 in human skeletal muscle. For this purpose, a biopsy was taken from m. vastus lateralis in 10 young healthy volunteers and 70 patients (26-85 years old) with long-term primary arthrosis of the knee/hip joint...
February 2024: Biochemistry. Biokhimii︠a︡