keyword
https://read.qxmd.com/read/38523672/the-key-mediator-of-diabetic-kidney-disease-potassium-channel-dysfunction
#21
REVIEW
Jia Guo, Chaojie Zhang, Hui Zhao, Yufan Yan, Zhangsuo Liu
Diabetic kidney disease is a leading cause of end-stage renal disease, making it a global public health concern. The molecular mechanisms underlying diabetic kidney disease have not been elucidated due to its complex pathogenesis. Thus, exploring these mechanisms from new perspectives is the current focus of research concerning diabetic kidney disease. Ion channels are important proteins that maintain the physiological functions of cells and organs. Among ion channels, potassium channels stand out, because they are the most common and important channels on eukaryotic cell surfaces and function as the basis for cell excitability...
July 2024: Genes & Diseases
https://read.qxmd.com/read/38523634/integrated-chemical-characterization-metabolite-profiling-and-pharmacokinetics-analysis-of-zhijun-tangshen-decoction-by-uplc-q-tof-ms
#22
JOURNAL ARTICLE
Qingheng Tong, Yueyue Chang, Guanxiong Shang, Jiu Yin, Xiaoqi Zhou, Suwei Wang, Xiaofeng Yan, Fangfang Zhang, Suqin Wang, Weifeng Yao
Diabetic nephropathy (DN) is the main cause of end-stage renal disease worldwide and a major public issue affecting the health of people. Therefore, it is essential to explore effective drugs for the treatment of DN. In this study, the traditional Chinese medicine (TCM) formula, Zhijun Tangshen Decoction (ZJTSD), a prescription modified from the classical formula Didang Decoction, has been used in the clinical treatment of DN. However, the chemical basis underlying the therapeutic effects of ZJTSD in treating DN remains unknown...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38523631/jian-pi-gu-shen-hua-yu-decoction-alleviated-diabetic-nephropathy-in-mice-through-reducing-ferroptosis
#23
JOURNAL ARTICLE
Shuquan Lv, Lirong Fan, Xiaoting Chen, Xiuhai Su, Li Dong, Qinghai Wang, Yuansong Wang, Hui Zhang, Huantian Cui, Shufang Zhang, Lixin Wang
BACKGROUND: Diabetic nephropathy (DN), one of the most frequent complications of diabetes mellitus, is a leading cause of end-stage renal disease. However, the current treatment methods still cannot effectively halt the progression of DN. Jian-Pi-Gu-Shen-Hua-Yu (JPGS) decoction can be used for the treatment of chronic kidney diseases such as DN, but the specific mechanism of action has not been fully elucidated yet. PURPOSE: The aim of this study is to clarify whether JPGS alleviates the progression of diabetic nephropathy by inhibiting ferroptosis...
2024: Journal of Diabetes Research
https://read.qxmd.com/read/38523465/prediction-of-cardiovascular-and-renal-risk-among-patients-with-apparent-treatment-resistant-hypertension-in-the-united-states-using-machine-learning-methods
#24
JOURNAL ARTICLE
George Bakris, Pei Paul Lin, Chang Xu, Cindy Chen, Veronica Ashton, Mukul Singhal
Apparent treatment-resistant hypertension (aTRH), defined as blood pressure (BP) that remains uncontrolled despite unconfirmed concurrent treatment with three antihypertensives, is associated with an increased risk of developing cardiovascular and renal complications compared with controlled hypertension. We aimed to identify the characteristics of aTRH patients with an elevated risk of major adverse cardiovascular events plus (MACE+; defined as stroke, myocardial infarction, or heart failure hospitalization) and end stage renal disease (ESRD)...
March 24, 2024: Journal of Clinical Hypertension
https://read.qxmd.com/read/38522724/iqcb1-nphp5-retinopathy-clinical-and-genetic-characterization-and-natural-history
#25
JOURNAL ARTICLE
Sagnik Sen, Lorenzo Fabozzi, Kaoru Fujinami, Yu Fujinami-Yokokawa, Genevieve A Wright, Andrew Webster, Omar Mahroo, Anthony G Robson, Michalis Georgiou, Michel Michaelides
PURPOSE: To describe the clinical and genetic features, and explore the natural history of retinopathy associated with IQCB1 variants in children and adults with retinopathy. DESIGN: Retrospective cohort study at a single tertiary care referral center. METHODS: The study recruited 19 patients with retinopathy, harboring likely disease-causing variants in IQCB1. Demographic data and clinical presentation, best corrected visual acuity (BCVA), fundus appearance, optical coherence tomography (OCT) and autofluorescence features, electroretinography (ERG) and molecular genetics are reported...
March 22, 2024: American Journal of Ophthalmology
https://read.qxmd.com/read/38521518/effects-of-haemodiafiltration-or-haemofiltration-compared-with-haemodialysis-on-prognosis-in-patients-with-end-stage-renal-disease-protocol-an-updated-systematic-review-and-meta-analysis-of-randomised-trials-with-trial-sequential-analysis
#26
JOURNAL ARTICLE
Fan Zhang, Jing Liao, Yan Bai, Zixuan Zhang, Liuyan Huang, Yifei Zhong
INTRODUCTION: Haemodialysis is the most common treatment option for patients with life-sustaining end-stage kidney disease (ESKD). In recent years, haemodiafiltration or haemofiltration has been widely used in patients with ESKD, and there are still conflicting findings as to whether both are superior to traditional haemodialysis. This systematic review and meta-analysis were designed to determine whether haemodiafiltration or haemofiltration is more effective than haemodialysis in reducing all-cause mortality risk in patients with ESKD...
March 23, 2024: BMJ Open
https://read.qxmd.com/read/38520403/prevalence-of-non-neurogenic-male-lower-urinary-tract-symptoms-after-kidney-transplantation
#27
REVIEW
Alberto Costa Silva, Teresa Pina-Vaz, Afonso Morgado, Carlos Martins-Silva, Tiago Antunes-Lopes, João Alturas Silva
OBJECTIVE: This review investigates the prevalence of male non-neurogenic lower urinary tract symptoms (LUTS) after renal transplant, as kidney transplantation is a transformative intervention for patients with end-stage renal disease significantly enhancing quality of life that might be diminished by LUTS. METHODS: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed. A systematic search in the PubMed and Scopus databases was performed using specific terms...
March 23, 2024: BJU International
https://read.qxmd.com/read/38518919/glycated-albumin-and-adverse-clinical-outcomes-in-patients-with-ckd-a-prospective-cohort-study
#28
JOURNAL ARTICLE
Mengyao Tang, Anders H Berg, Hui Zheng, Eugene P Rhee, Andrew S Allegretti, Sagar U Nigwekar, S Ananth Karumanchi, James P Lash, Sahir Kalim
RATIONALE & OBJECTIVE: HbA1c is widely used to estimate glycemia, yet it is less reliable in patients with chronic kidney disease (CKD). There is growing interest in the complementary use of glycated albumin (GA) to improve glycemic monitoring and risk stratification. However, whether GA associates with clinical outcomes in a non-dialysis dependent CKD population remains unknown. STUDY DESIGN: Prospective cohort study. SETTING: & Participants: 3110 participants with CKD from the Chronic Renal Insufficiency Cohort study...
March 20, 2024: American Journal of Kidney Diseases
https://read.qxmd.com/read/38516340/improvement-in-proteinuria-with-sodium-glucose-cotransporter-2-inhibitors-and-esaxerenone-treatment-in-patients-with-chronic-allograft-kidney-disease-a-case-report
#29
Shoichiro Daimon
Proteinuria is a predictor of end-stage renal disease. The effectiveness of an angiotensin-converting enzyme inhibitor or an angiotensin II receptor blocker for the reduction in urinary protein excretion and renoprotection in proteinuric chronic kidney disease patients is well known, and coadministration of and sodium-glucose cotransporter inhibitor and the mineralocorticoid receptor blocker eplerenone has recently demonstrated an additive albuminuria-lowering effect in chronic kidney disease patients. Proteinuria is also an independent predictor of end-stage renal disease in kidney transplant recipients...
2024: Clinical Nephrology. Case Studies
https://read.qxmd.com/read/38513825/change-over-time-in-pre-esrd-24-hour-urine-creatinine-as-muscle-mass-surrogate-and-post-esrd-mortality
#30
JOURNAL ARTICLE
Sahar Amin, Barry M Wall, Fridtjof Thomas, Kamyar Kalantar-Zadeh, Keiichi Sumida, Csaba P Kovesdy
OBJECTIVE: Loss of muscle mass and sarcopenia are common in CKD and ESRD, and sarcopenia can worsen insidiously in patients with advancing CKD. The temporal dynamics of sarcopenia in patients with progressive loss of kidney function, and its association with future outcomes, is unclear. METHODS: In a contemporary national cohort of incident ESRD US veterans, we selected 661 patients who had at least two 24-hour urine creatinine (24hrUC) measurements, a surrogate of muscle mass, performed during the 3-year prelude period prior to ESRD transition...
March 19, 2024: Journal of Renal Nutrition
https://read.qxmd.com/read/38512913/comparison-of-ekfc-pakistani-ckd-epi-and-2021-race-free-ckd-epi-creatinine-equations-in-south-asian-ckd-population-a-study-from-pakistani-ckd-community-cohort
#31
JOURNAL ARTICLE
Aqsa Safdar, Waqas Akram, Mahtab Ahmad Khan, Danish Tahir, Muhammad Hammad Butt
INTRODUCTION: South Asian individuals possess a high risk of chronic kidney disease. There is a need to study, evaluate, and compare the newly suggested glomerular filtration rate (eGFR) equations for accurate CKD diagnosis, staging, and drug dosing. This study aimed to (1) evaluate the European Kidney Function Consortium (EKFC), Pakistani CKD-EPI, and 2021 Race-Free CKD-EPI creatinine equation in the South Asian population with CKD and (2) to examine the expected implications on both CKD classification as well as End Stage Renal Disease (ESRD) prevalence across these equations in South Asian population...
2024: PloS One
https://read.qxmd.com/read/38512379/factors-influencing-renal-replacement-therapy-modality-choice-from-the-nephrologist-s-perspective
#32
JOURNAL ARTICLE
Charlotte Cortvrindt, Wim Van Biesen, Guiseppe Gambino, Anne-Lorraine Clause
BACKGROUND: Peritoneal dialysis (PD) offers quality of life and empowerment for persons with end-stage kidney disease (ESKD). Nevertheless, the prevalence of PD is low in Belgium and Europe in general. Reimbursement, patient mix and late referral have been quoted as underlying reasons. However, to date no one-size-fits-all solution increasing uptake of PD has been successfully implemented. We aimed to understand the nephrologist's perspective, beliefs, and experiences on dialysis modality selection and to clarify underlying process-level and intrinsic motivations steering final decisions...
March 21, 2024: Journal of Nephrology
https://read.qxmd.com/read/38512370/significance-of-the-total-renal-chronicity-score-in-predicting-renal-outcome-in-pla2r-associated-membranous-nephropathy
#33
JOURNAL ARTICLE
Weifu Ren, Jing Sun, Lingyan Zhang, Wei He, Zhiyong Guo, Qi Bian
BACKGROUND: Phospholipase A2 receptor (PLA2R)-associated membranous nephropathy accounts for the majority of membranous nephropathy; however, few studies have determined the prognostic impact and clinical application of renal pathologic change on this disease. METHODS: A retrospective cohort study of 262 patients with PLA2R-associated membranous nephropathy was conducted. The total renal chronicity score calculated according to the degree of glomerulosclerosis, interstitial fibrosis, tubular atrophy, and arteriosclerosis was applied to evaluate renal chronicity...
March 21, 2024: Journal of Nephrology
https://read.qxmd.com/read/38511986/laparoscopic-nephrectomy-via-the-retroperitoneal-approach-for-autosomal-dominant-polycystic-kidney-disease-after-renal-transplant-a-case-report
#34
Kazuro Kikkawa, Hiraku Yamamoto, Yasuo Kohjimoto, Isao Hara
We report a case of laparoscopic nephrectomy via the retroperitoneal approach for autosomal dominant polycystic kidney disease after renal transplant. A 54-year-old male patient with end-stage renal failure because of autosomal dominant polycystic kidney disease underwent a living donor renal transplant and right nephrectomy via open surgery through a median abdominal incision 5 years previously. However, the left kidney gradually became enlarged. We performed laparoscopic left nephrectomy via the retroperitoneal approach...
February 2024: Experimental and Clinical Transplantation
https://read.qxmd.com/read/38511980/renal-transplant-in-elderly-end-stage-renal-disease-patients-impact-of-comorbidities-and-posttransplant-adverse-events-on-outcomes
#35
JOURNAL ARTICLE
Mohamed Yehia Hamdy, Hayam El Aggan, Iman El Gohary, Ahmed Halawa
OBJECTIVES: Elderly renal transplant continues to be debated because of age-related factors affecting transplant success and long-term prognosis. We investigated the effects ofrecipient age and predictors of renal transplant outcomes in elderly renal transplant recipients. MATERIALS AND METHODS: We retrospectively analyzed 506 patients who had a first renal transplant between January 2010 and December 2020; there were 165 recipients aged ≥60 years (elderly) and 341 recipients aged <60 years (young)...
February 2024: Experimental and Clinical Transplantation
https://read.qxmd.com/read/38511240/successful-management-of-fatal-cardiac-tamponade-resulting-from-intravascular-intervention-for-central-vein-occlusion-in-hemodialysis-patients-a-case-report
#36
JOURNAL ARTICLE
Wenhui Lei, Weidong Huang, Jun Xin
This case report highlights the successful management of fatal cardiac tamponade caused by intravascular intervention for central vein occlusion in hemodialysis patients. Prompt diagnosis and treatment are essential for patient prognosis in such cases. We present a case involving a challenging surgical procedure to address multiple complications, emphasizing the importance of early detection and appropriate interventions. The patient, who had a history of long-term central venous catheter use for hemodialysis, was diagnosed with central vein stenosis in addition to superior vena cava occlusion, hemodialysis catheter rupture, hypertension, and end-stage renal disease...
March 21, 2024: Journal of Vascular Access
https://read.qxmd.com/read/38510948/a-randomized-controlled-trial-evaluating-a-theory-driven-complex-intervention-centered-on-task-sharing-and-mobile-health-to-improve-selfcare-and-outcomes-in-heart-failure-the-panacea-hf-rct-design-and-rationale
#37
JOURNAL ARTICLE
D Y Kamath, J Abdullakutty, B B Granger, S Kulkarni, K B Bhuvana, L J Salazar, S Shifra, J Idiculla, J Narendra, K Varghese, D Xavier
BACKGROUND: We developed a three-pronged complex intervention to improve selfcare and deliver whole person care for patients with heart failure, underpinned by the 'extant cycle' theory - a theory based on our formative work. METHODS: This is a 3 centre, 2-arm, 1:1, open, adaptive stratified, randomized controlled trial. We included patients aged ≥ 18 years with heart failure, taking any of the key guideline directed medical treatments, with a history of or currently on a high ceiling diuretic...
October 2023: American heart journal plus: cardiology research and practice
https://read.qxmd.com/read/38510762/acute-kidney-injury-in-patients-undergoing-extracorporeal-membrane-oxygenation-a-retrospective-cohort-study
#38
JOURNAL ARTICLE
Aswin Surjit, Bipi Prasannan, Jobin Abraham, Anuroop Balagopal, Vavullipathy Narayanan Unni
AIMS AND BACKGROUND: Extracorporeal membrane oxygenation (ECMO) is a mode of extracorporeal therapy to support oxygenation of patients with severe cardiac or respiratory failure. Studies have shown that acute kidney injury (AKI) can worsen the outcome in these patients. This study aims to assess the incidence and outcome of AKI in patients on ECMO support. MATERIALS AND METHODS: This retrospective study included 64 patients who underwent ECMO for more than 24 hours...
January 2024: Indian Journal of Critical Care Medicine
https://read.qxmd.com/read/38510702/causal-relationship-between-pcsk9-inhibitor-and-primary-glomerular-disease-a-drug-target-mendelian-randomization-study
#39
JOURNAL ARTICLE
Hangyu Duan, Yue Shi, Qi Zhang, Xiujie Shi, Yifan Zhang, Jing Liu, Yu Zhang
BACKGROUND: Successive observational studies have highlighted low-density lipoprotein cholesterol (LDL-C) as a standalone risk factor for the progression of chronic kidney disease (CKD) to end-stage renal disease. Lowering LDL-C levels significantly reduces the incidence of atherosclerotic events in patients with progressive CKD. Recent research indicates that proprotein convertase subtilisin kexin 9 (PCSK9) inhibitors not only effectively lower LDL-C levels in CKD patients but also exhibit therapeutic potential for autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, and ulcerative colitis...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38510097/inferior-vena-cava-reconstruction-to-alleviate-back-pain
#40
Angel Hsu, Michael S Segal, Michael Addis
We present the case of a 38-year-old man with end-stage renal disease receiving hemodialysis via a left femoral loop graft who developed debilitating back pain. During a maintenance fistulogram, we found a completely occluded inferior vena cava and engorged lumbar veins. The patient underwent inferior vena cava reconstruction with stenting, which resulted in complete resolution of the engorged lumbar veins on venography and a significant reduction in his back pain. Engorgement of the lumbar veins can cause significant pain, and treatment of the underlying pathology can alleviate these symptoms...
June 2024: Journal of Vascular Surgery Cases and Innovative Techniques
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